5,428 results on '"Oizumi, A."'
Search Results
2. Salivary metabolites as potential predictive biomarkers for lung surgery complications: a retrospective cross-sectional study
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Takamori, Satoshi, Ishikawa, Shigeo, Sato, Kaito, Watanabe, Hikaru, Suzuki, Jun, Oizumi, Hiroyuki, Shiono, Satoshi, Uchida, Tetsuro, Okuyama, Naoki, Edamatsu, Kaoru, Iino, Mitsuyoshi, and Sugimoto, Masahiro
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- 2024
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3. Decomposing Thermodynamic Dissipation of Linear Langevin Systems via Oscillatory Modes and Its Application to Neural Dynamics
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Sekizawa, Daiki, Ito, Sosuke, and Oizumi, Masafumi
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Quantitative Biology - Neurons and Cognition ,Condensed Matter - Statistical Mechanics - Abstract
Recent developments in stochastic thermodynamics have elucidated various relations between the entropy production rate (thermodynamic dissipation) and the physical limits of information processing in nonequilibrium dynamical systems. These findings have opened new perspectives in analyzing real biological systems. In neuroscience, the importance of quantifying entropy production has attracted attention for understanding information processing in the brain. However, the relationship between the entropy production rate and oscillations, which are common in many biological systems, remains unclear. For instance, neural oscillations like delta, theta, and alpha waves play crucial roles in brain information processing. Here, we derive a novel decomposition of the entropy production rate of linear Langevin systems. We show that one component of the entropy production rate, called the housekeeping entropy production rate, can be decomposed into independent positive contributions from oscillatory modes. Our decomposition enables us to calculate the contribution of oscillatory modes to the housekeeping entropy production rate. In addition, when the noise matrix is diagonal, the contribution of each oscillatory mode can be further decomposed into the contribution of each system element. To demonstrate the utility of our decomposition, we applied it to an electrocorticography (ECoG) dataset recorded during awake and anesthetized conditions in monkeys, where the oscillatory properties change drastically. We showed consistent trends across different monkeys: the contribution of delta band was larger in the anesthetized condition than in the awake condition, while those from higher frequency bands, such as the theta band, were smaller. These results allow us to interpret the changes in neural oscillation in terms of stochastic thermodynamics and the physical limits of information processing.
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- 2023
4. Gromov-Wasserstein unsupervised alignment reveals structural correspondences between the color similarity structures of humans and large language models
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Kawakita, Genji, Zeleznikow-Johnston, Ariel, Tsuchiya, Naotsugu, and Oizumi, Masafumi
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Quantitative Biology - Neurons and Cognition - Abstract
Large Language Models (LLMs), such as the General Pre-trained Transformer (GPT), have shown remarkable performance in various cognitive tasks. However, it remains unclear whether these models have the ability to accurately infer human perceptual representations. Previous research has addressed this question by quantifying correlations between similarity response patterns of humans and LLMs. Correlation provides a measure of similarity, but it relies pre-defined item labels and does not distinguish category- and item- level similarity, falling short of characterizing detailed structural correspondence between humans and LLMs. To assess their structural equivalence in more detail, we propose the use of an unsupervised alignment method based on Gromov-Wasserstein optimal transport (GWOT). GWOT allows for the comparison of similarity structures without relying on pre-defined label correspondences and can reveal fine-grained structural similarities and differences that may not be detected by simple correlation analysis. Using a large dataset of similarity judgments of 93 colors, we compared the color similarity structures of humans (color-neurotypical and color-atypical participants) and two GPT models (GPT-3.5 and GPT-4). Our results show that the similarity structure of color-neurotypical participants can be remarkably well aligned with that of GPT-4 and, to a lesser extent, to that of GPT-3.5. These results contribute to the methodological advancements of comparing LLMs with human perception, and highlight the potential of unsupervised alignment methods to reveal detailed structural correspondences. This work has been published in Scientific Reports, DOI: https://doi.org/10.1038/s41598-024-65604-1.
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- 2023
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5. Gromov–Wasserstein unsupervised alignment reveals structural correspondences between the color similarity structures of humans and large language models
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Genji Kawakita, Ariel Zeleznikow-Johnston, Naotsugu Tsuchiya, and Masafumi Oizumi
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Large language models ,Unsupervised alignment ,Gromov–Wasserstein optimal transport ,Color similarity structures ,Medicine ,Science - Abstract
Abstract Large Language Models (LLMs), such as the General Pre-trained Transformer (GPT), have shown remarkable performance in various cognitive tasks. However, it remains unclear whether these models have the ability to accurately infer human perceptual representations. Previous research has addressed this question by quantifying correlations between similarity response patterns of humans and LLMs. Correlation provides a measure of similarity, but it relies pre-defined item labels and does not distinguish category- and item- level similarity, falling short of characterizing detailed structural correspondence between humans and LLMs. To assess their structural equivalence in more detail, we propose the use of an unsupervised alignment method based on Gromov–Wasserstein optimal transport (GWOT). GWOT allows for the comparison of similarity structures without relying on pre-defined label correspondences and can reveal fine-grained structural similarities and differences that may not be detected by simple correlation analysis. Using a large dataset of similarity judgments of 93 colors, we compared the color similarity structures of humans (color-neurotypical and color-atypical participants) and two GPT models (GPT-3.5 and GPT-4). Our results show that the similarity structure of color-neurotypical participants can be remarkably well aligned with that of GPT-4 and, to a lesser extent, to that of GPT-3.5. These results contribute to the methodological advancements of comparing LLMs with human perception, and highlight the potential of unsupervised alignment methods to reveal detailed structural correspondences.
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- 2024
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6. Passive shoulder abduction range of motion at 3 months postoperatively is the most important prognostic factor for achieving full recovery of range of motion at 6 months after arthroscopic rotator cuff repair
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Yu Ito, RPT, MSc, Tomoya Ishida, RPT, PhD, Hisashi Matsumoto, RPT, Shota Yamaguchi, RPT, Naoki Suenaga, MD, PhD, Naomi Oizumi, MD, PhD, Chika Yoshioka, MD, PhD, Shintaro Yamane, MD, PhD, Yukiyoshi Hisada, MD, and Tomoya Matsuhashi, MD, PhD
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Arthroscopic rotator cuff repair ,Rehabilitation ,Prognostic factors ,Cutoff value ,Abduction range of motion ,Preoperative range of motion ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Background: After arthroscopic rotator cuff repair (ARCR), it is crucial for clinicians to predict the functional recovery in the early postoperative period for considering rehabilitation strategies. The aim of this study was to identify the prognostic factors in the early postoperative period for achieving full recovery of range of motion (ROM) at 6 months after ARCR. Methods: This study included 184 patients who underwent ARCR. Patients were divided into the full recovery and nonrecovery groups using the Constant ROM score at 6 months postoperatively. The area under the curve for predicting the full recovery group was calculated for all independent variables such as demographic data, ROM, shoulder functional scores at preoperative and 3 months postoperative using receiver operating characteristic curve analysis. Multivariable logistic regression analysis was then performed using candidate variables with an area under the curve of 0.7 or greater to determine prognostic factors for full recovery at 6 months postoperatively. The same analysis as above was also performed by dividing the patients into groups according to their preoperative ROM. Results: Multivariable logistic regression analysis revealed that preoperative active flexion, 3 months postoperative passive abduction, and internal rotation at 90° abduction ROM were significant prognostic factors of achieving full ROM recovery at 6 months postoperatively. Only passive abduction ROM at 3 months postoperatively was significantly extracted in the preoperative ROM limitation group. Conclusion: This study demonstrated that passive abduction ROM at 3 months postoperatively was a significant prognostic factor of achieving full recovery of ROM at 6 months after ARCR.
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- 2024
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7. AOBA: The Most Powerful Vector Supercomputer in the World
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Takizawa, Hiroyuki, Takahashi, Keichi, Shimomura, Yoichi, Egawa, Ryusuke, Oizumi, Kenji, Ono, Satoshi, Yamashita, Takeshi, Saito, Atsuko, Resch, Michael M., editor, Gebert, Johannes, editor, Kobayashi, Hiroaki, editor, Takizawa, Hiroyuki, editor, and Bez, Wolfgang, editor
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- 2024
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8. Gromov–Wasserstein unsupervised alignment reveals structural correspondences between the color similarity structures of humans and large language models
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Kawakita, Genji, Zeleznikow-Johnston, Ariel, Tsuchiya, Naotsugu, and Oizumi, Masafumi
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- 2024
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9. Exacerbation of delirium and epileptic seizures in an older man with idiopathic Parkinson’s disease due to multiple prescriptions: a case report
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Takuya Yamaguchi, Akinobu Aihara, Shigeto Mashiko, Emiko Kurosawa, Tomoya Oizumi, Toshihiro Yamagata, Aiko Ishiki, Juri Ueda, Yuko Fujikawa, Atsuhiro Kanno, Kazuhiro Sumitomo, Takahiro Ohara, and Katsutoshi Furukawa
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Parkinson’s disease ,polypharmacy ,delirium ,Parkinson’s disease psychosis ,renal dysfunction ,Medicine (General) ,R5-920 - Abstract
IntroductionParkinson’s disease (PD) is a disorder characterized by motor symptoms, such as rigidity, akinesia, and resting tremor, as well as non-motor symptoms, including psychiatric manifestations and autonomic failure. The prevalence of PD increases with age, and the condition is more common in men than in women. Conversely, polypharmacy has emerged as a paramount medical concern, especially among older patients, correlating with medicines’ adverse effects, interactions between medicines, frequent admissions to the hospital, and a high risk of morbidity and mortality.Case descriptionWe encountered an older male patient with idiopathic PD and mild renal dysfunction. Originally prescribed 14 types of medicines, including anti-PD drugs, the patient developed delirium and epileptic seizures during hospitalization. After reducing the number of medications, including amantadine, the symptoms significantly improved. This clinical course suggests that polypharmacy, in addition to PD itself, poses a significant risk of delirium and epileptic seizures, even in patients with mild renal dysfunction.ConclusionThis report is indicative of the risk of polypharmacy and highlights the importance of citing drug interactions for a correct diagnosis in patients presenting with complex symptoms.
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- 2024
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10. Learning Curve for Thoracoscopic Individual Basilar Segmentectomy: 18-Year Experience
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Takamori, Satoshi, Oizumi, Hiroyuki, Suzuki, Jun, Watanabe, Hikaru, Sato, Kaito, Shiono, Satoshi, and Sho, Ri
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- 2023
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11. Rab11a Controls Cell Shape via C9orf72 Protein: Possible Relationships to Frontotemporal Dementia/Amyotrophic Lateral Sclerosis (FTDALS) Type 1
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Shoya Fukatsu, Hinami Sashi, Remina Shirai, Norio Takagi, Hiroaki Oizumi, Masahiro Yamamoto, Katsuya Ohbuchi, Yuki Miyamoto, and Junji Yamauchi
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Rab ,FTDALS ,hesperetin ,N1E-115 ,FBD-102b ,Physiology ,QP1-981 - Abstract
Abnormal nucleotide insertions of C9orf72, which forms a complex with Smith–Magenis syndrome chromosomal region candidate gene 8 (SMCR8) protein and WD repeat-containing protein 41 (WDR41) protein, are associated with an autosomal-dominant neurodegenerative frontotemporal dementia and/or amyotrophic lateral sclerosis type 1 (FTDALS1). The differentially expressed in normal and neoplastic cells (DENN) domain-containing C9orf72 and its complex with SMCR8 and WDR41 function as a guanine-nucleotide exchange factor for Rab GTP/GDP-binding proteins (Rab GEF, also called Rab activator). Among Rab proteins serving as major effectors, there exists Rab11a. However, it remains to be established which Rab protein is related to promoting or sustaining neuronal morphogenesis or homeostasis. In this study, we describe that the knockdown of Rab11a decreases the expression levels of neuronal differentiation marker proteins, as well as the elongation of neurite-like processes, using N1E-115 cells, a well-utilized neuronal differentiation model. Similar results were obtained in primary cortical neurons. In contrast, the knockdown of Rab11b, a Rab11a homolog, did not significantly affect their cell morphological changes. It is of note that treatment with hesperetin, a citrus flavonoid (also known as Vitamin P), recovered the neuronal morphological phenotypes induced by Rab11a knockdown. Also, the knockdown of Rab11a or Rab11b led to a decrease in glial marker expression levels and in morphological changes in FBD-102b cells, which serve as the oligodendroglial differentiation model. Rab11a is specifically involved in the regulation of neuronal morphological differentiation. The knockdown effect mimicking the loss of function of C9orf72 is reversed by treatment with hesperetin. These findings may reveal a clue for identifying one of the potential molecular and cellular phenotypes underlying FTDALS1.
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- 2024
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12. Modulating Golgi Stress Signaling Ameliorates Cell Morphological Phenotypes Induced by CHMP2B with Frontotemporal Dementia-Associated p.Asp148Tyr
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Shoya Fukatsu, Maho Okawa, Miyu Okabe, Mizuka Cho, Mikinori Isogai, Takanori Yokoi, Remina Shirai, Hiroaki Oizumi, Masahiro Yamamoto, Katsuya Ohbuchi, Yuki Miyamoto, and Junji Yamauchi
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CHMP2B ,Golgi stress ,Hsp47 ,Arf4 ,differentiation ,Biology (General) ,QH301-705.5 - Abstract
Some charged multivesicular body protein 2B (CHMP2B) mutations are associated with autosomal-dominant neurodegenerative frontotemporal dementia and/or amyotrophic lateral sclerosis type 7 (FTDALS7). The main aim of this study is to clarify the relationship between the expression of mutated CHMP2B protein displaying FTD symptoms and defective neuronal differentiation. First, we illustrate that the expression of CHMP2B with the Asp148Tyr (D148Y) mutation, which preferentially displays FTD phenotypes, blunts neurite process elongation in rat primary cortical neurons. Similar results were observed in the N1E-115 cell line, a model that undergoes neurite elongation. Second, these effects were also accompanied by changes in neuronal differentiation marker protein expression. Third, wild-type CHMP2B protein was indeed localized in the endosomal sorting complexes required to transport (ESCRT)-like structures throughout the cytoplasm. In contrast, CHMP2B with the D148Y mutation exhibited aggregation-like structures and accumulated in the Golgi body. Fourth, among currently known Golgi stress regulators, the expression levels of Hsp47, which has protective effects on the Golgi body, were decreased in cells expressing CHMP2B with the D148Y mutation. Fifth, Arf4, another Golgi stress-signaling molecule, was increased in mutant-expressing cells. Finally, when transfecting Hsp47 or knocking down Arf4 with small interfering (si)RNA, cellular phenotypes in mutant-expressing cells were recovered. These results suggest that CHMP2B with the D148Y mutation, acting through Golgi stress signaling, is negatively involved in the regulation of neuronal cell morphological differentiation, providing evidence that a molecule controlling Golgi stress may be one of the potential FTD therapeutic targets at the molecular and cellular levels.
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- 2024
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13. Thoracoscopic posterior approach for an S6 left lower lobe segmentectomy in a patient with an incomplete fissure: A case report
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Yusuke Matsui, Hiroyuki Oizumi, Hikaru Watanabe, Akihiro Takeshi, Megumi Nakamura, and Satoshi Shiono
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Thoracoscopy ,Posterior approach ,Incomplete interlobar fissure ,Segmentectomy ,Fissure-less ,Case report ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Introduction: Thoracoscopic superior-segment (S6) segmentectomy is a simple procedure. However, it is applicable only when an interlobar fissure approach is applied, which can sometimes be challenging in cases with a fused interlobar fissure. Herein, we discuss our experience in performing thoracoscopic left S6 segmentectomy in a pediatric patient with congenital pulmonary airway malformation (CPAM) involving a fused interlobar fissure. Case presentation: A 5-year-old girl was prenatally diagnosed with a cystic mass in her left thorax and suspected to have a congenital pulmonary airway malformation. No postnatal respiratory symptoms were observed; elective surgery was performed after reaching the age when differential lung ventilation became feasible. Multiportal complete thoracoscopic surgery was performed under general anesthesia. A large cyst was identified in S6, and the interlobar fissure was fused; thus, we performed a fissure-last S6 segmentectomy using a posterior approach. We first manipulated the vein by retracting the lower lobe anteriorly thus enabling us to identify the segmental veins (V6), and subsequently divide V6a and V6c. We divided segmental arterial branches and separated the intersegmental plane between the S6 and basal segment along V6b using staplers. Lastly, the fused interlobar fissure was divided using a stapler. No postoperative leakage was observed, and the chest tube was removed on the evening of the day of surgery. Pathological examination revealed CPAM type 1 with no malignant findings. The patient survived and is living without any complications 16 months postoperatively. Conclusion: The fissure-last method may be an alternative treatment for patients with incomplete interlobar fissures.
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- 2024
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14. Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice
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Yuko Maejima, Shoko Yokota, Megumi Yamachi, Shingen Misaka, Tomoyuki Ono, Hiroaki Oizumi, Keita Mizuno, Shizu Hidema, Katsuhiko Nishimori, Masato Aoyama, Heidi de Wet, and Kenju Shimomura
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high fat diet ,inflammatory cytokine ,Kamikihito ,sucrose preference ,traditional Japanese medicine ,oxytocin receptor ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
The high prevalence of obesity has become a pressing global public health problem and there exists a strong association between increased BMI and mortality at a BMI of 25 kg/m2 or higher. The prevalence of obesity is higher among middle-aged adults than among younger groups and the combination of aging and obesity exacerbate systemic inflammation. Increased inflammatory cytokines such as interleukin 6 and tumor necrosis factor alpha (TNFα) are hallmarks of obesity, and promote the secretion of hepatic C-reactive protein (CRP) which further induces systematic inflammation. The neuropeptide oxytocin has been shown to have anti-obesity and anti-inflammation effects, and also suppress sweet-tasting carbohydrate consumption in mammals. Previously, we have shown that the Japanese herbal medicine Kamikihito (KKT), which is used to treat neuropsychological stress disorders in Japan, functions as an oxytocin receptors agonist. In the present study, we further investigated the effect of KKT on body weight (BW), food intake, inflammation, and sweet preferences in middle-aged obese mice. KKT oral administration for 12 days decreased the expression of pro-inflammatory cytokines in the liver, and the plasma CRP and TNFα levels in obese mice. The effect of KKT administration was found to be different between male and female mice. In the absence of sucrose, KKT administration decreased food intake only in male mice. However, while having access to a 30% sucrose solution, both BW and food intake was decreased by KKT administration in male and female mice; but sucrose intake was decreased in female mice alone. In addition, KKT administration decreased sucrose intake in oxytocin deficient lean mice, but not in the WT lean mice. The present study demonstrates that KKT ameliorates chronic inflammation, which is strongly associated with aging and obesity, and decreases food intake in male mice as well as sucrose intake in female mice; in an oxytocin receptor dependent manner.
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- 2024
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15. A case of a stuck mesh in the rectum after pelvic surgery
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Makoto Eizuka, Yosuke Toya, Risaburo Akasaka, Shun Yamada, Tomofumi Oizumi, Satoshi Kasugai, Shunichi Yanai, Yoshihiko Sugimura, and Takayuki Matsumoto
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granulation tissue ,magnifying endoscopy ,mesh ,pelvic surgery ,rectal foreign body ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract A 67‐year‐old woman was referred to our hospital for further evaluation of a positive fecal occult blood test. Colonoscopy revealed an elevated rectal lesion (10 mm in size) with a central depression. A rod‐like object was noted in the center of the lesion. Magnifying endoscopy with narrow‐band imaging showed obscure surface structures and dilated vessels. Magnifying endoscopy with crystal violet staining showed that the pit pattern had disappeared. These endoscopic findings suggested that the lesion was comprised of granulation tissue. A detailed medical history revealed that she had undergone a total hysterectomy with mesh placement for bladder prolapse. We reasoned that the mesh used during pelvic surgery might have penetrated the rectum. She underwent subsequent surgery to remove the mesh. Although most foreign bodies in the rectum are swallowed or self‐inserted, pelvic surgery is another source of foreign bodies in the rectum.
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- 2024
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16. Association between lifestyle and skin moisturizing function in community-dwelling older adults
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Ryosuke Oizumi and Rie Shibata
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Skin moisturisation ,lifestyle ,older adults ,Dermatology ,RL1-803 - Abstract
The skin moisturizing function decline with age, leading to skin dryness in approximately 40% of the olderly. Various lifestyle habits may affect the skin moisturizing function, however it is not clear which ones are particularly relevant. A cross-sectional study was conducted between September and December 2023, involving individuals aged 65 years and older. Self-administered questionnaire were employed to collect information on lifestyle habits. Stratum corneum hydration (SC hydration), as an indicator of skin hydration, was measured and analyzed using multiple regression. A total of 124 individuals participated in the study, with a mean age of 83.6 years. Daily use of moisturizer (p=0.024) and activity level (p=0.002) demonstrated significant associations with increased SC hydration. Although not statistically significant, smoking exhibited a trend towards decreased SC hydration (p=0.173). The findings of this study suggest that, among various lifestyle habits, exercise and daily moisturizing contribute to enhanced SC hydration. These results suggest that lifestyle modifications may improve the skin moisturizing function of olderly.
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- 2024
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17. Cartesian Tree Subsequence Matching
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Oizumi, Tsubasa, Kai, Takeshi, Mieno, Takuya, Inenaga, Shunsuke, and Arimura, Hiroki
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Computer Science - Data Structures and Algorithms - Abstract
Park et al. [TCS 2020] observed that the similarity between two (numerical) strings can be captured by the Cartesian trees: The Cartesian tree of a string is a binary tree recursively constructed by picking up the smallest value of the string as the root of the tree. Two strings of equal length are said to Cartesian-tree match if their Cartesian trees are isomorphic. Park et al. [TCS 2020] introduced the following Cartesian tree substring matching (CTMStr) problem: Given a text string $T$ of length $n$ and a pattern string of length $m$, find every consecutive substring $S = T[i..j]$ of a text string $T$ such that $S$ and $P$ Cartesian-tree match. They showed how to solve this problem in $\tilde{O}(n+m)$ time. In this paper, we introduce the Cartesian tree subsequence matching (CTMSeq) problem, that asks to find every minimal substring $S = T[i..j]$ of $T$ such that $S$ contains a subsequence $S'$ which Cartesian-tree matches $P$. We prove that the CTMSeq problem can be solved efficiently, in $O(m n p(n))$ time, where $p(n)$ denotes the update/query time for dynamic predecessor queries. By using a suitable dynamic predecessor data structure, we obtain $O(mn \log \log n)$-time and $O(n \log m)$-space solution for CTMSeq. This contrasts CTMSeq with closely related order-preserving subsequence matching (OPMSeq) which was shown to be NP-hard by Bose et al. [IPL 1998].
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- 2022
18. Passive shoulder abduction range of motion at 3 months postoperatively is the most important prognostic factor for achieving full recovery of range of motion at 6 months after arthroscopic rotator cuff repair
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Ito, Yu, Ishida, Tomoya, Matsumoto, Hisashi, Yamaguchi, Shota, Suenaga, Naoki, Oizumi, Naomi, Yoshioka, Chika, Yamane, Shintaro, Hisada, Yukiyoshi, and Matsuhashi, Tomoya
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- 2024
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19. Residual middle lobectomy after right upper or lower lobectomy: indications and outcome
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Takamori, Satoshi, Oizumi, Hiroyuki, Suzuki, Jun, Watanabe, Hikaru, Sato, Kaito, Shiono, Satoshi, and Uchida, Tetsuro
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- 2023
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20. Long-term outcomes of hemiarthroplasty using a smaller head combined with rotator cuff reconstruction in patients with cuff-tear arthropathy
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Yoshioka, Chika, Suenaga, Naoki, Oizumi, Naomi, Yamane, Shintaro, Hisada, Yukiyoshi, Matsuhashi, Tomoya, Miyoshi, Naoki, and Kawamata, Jun
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- 2024
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21. Combined basilar subsegmentectomy for intralobar sequestration via uniportal VATS: a case report
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Takamori, Satoshi, Oizumi, Hiroyuki, Suzuki, Jun, and Shiono, Satoshi
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- 2023
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22. Ensemble rainfall–runoff and inundation simulations using 100 and 1000 member rainfalls by 4D LETKF on the Kumagawa River flooding 2020
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Kobayashi, Kenichiro, Duc, Le, Kawabata, Takuya, Tamura, Atsushi, Oizumi, Tsutao, Saito, Kazuo, Nohara, Daisuke, and Sumi, Tetsuya
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- 2023
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23. The Potential of Exercise on Lifestyle and Skin Function: Narrative Review
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Ryosuke Oizumi, Yoshie Sugimoto, and Hiromi Aibara
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Dermatology ,RL1-803 - Abstract
BackgroundThe skin is an important organ of the human body and has moisturizing and barrier functions. Factors such as sunlight and lifestyle significantly affect these skin functions, with sunlight being extremely damaging. The effects of lifestyle habits such as smoking, diet, and sleep have been studied extensively. It has been found that smoking increases the risk of wrinkles, while excessive fat and sugar intake leads to skin aging. Lack of sleep and stress are also dangerous for the skin’s barrier function. In recent years, the impact of exercise habits on skin function has been a focus of study. Regular exercise is associated with increased blood flow to the skin, elevated skin temperature, and improved skin moisture. Furthermore, it has been shown to improve skin structure and rejuvenate its appearance, possibly through promoting mitochondrial biosynthesis and affecting hormone secretion. Further research is needed to understand the effects of different amounts and content of exercise on the skin. ObjectiveThis study aims to briefly summarize the relationship between lifestyle and skin function and the mechanisms that have been elucidated so far and introduce the expected effects of exercise on skin function. MethodsWe conducted a review of the literature using PubMed and Google Scholar repositories for relevant literature published between 2000 and 2022 with the following keywords: exercise, skin, and life habits. ResultsExercise augments the total spectrum power density of cutaneous blood perfusion by a factor of approximately 8, and vasodilation demonstrates an enhancement of approximately 1.5-fold. Regular exercise can also mitigate age-related skin changes by promoting mitochondrial biosynthesis. However, not all exercise impacts are positive; for instance, swimming in chlorinated pools may harm the skin barrier function. Hence, the exercise environment should be considered for its potential effects on the skin. ConclusionsThis review demonstrates that exercise can potentially enhance skin function retention.
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- 2024
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24. Long-Term Efficacy and Safety of Lorlatinib in Japanese Patients With ALK-Positive Advanced NSCLC—A Brief Report From the CROWN Study
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Shunsuke Teraoka, MD, Hidetoshi Hayashi, MD, PhD, Yasushi Goto, MD, PhD, Makoto Nishio, MD, PhD, Shunichi Sugawara, MD, PhD, Takao Inoue, MD, Satoshi Oizumi, MD, PhD, Shigeyuki Toyoizumi, MS, Masakazu Matsumura, MS, Rossella Messina, PharmD, PhD, and Terufumi Kato, MD
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Anaplastic lymphoma kinase ,Japan ,Lorlatinib ,Non–small cell lung cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction: Lorlatinib was found to have improved efficacy versus crizotinib in the global phase 3 CROWN study (NCT03052608). Similar results were revealed for the Japanese population as for the overall population. We present results from the unplanned 3-year follow-up from the CROWN study in Japanese patients. Methods: Patients were randomized to either lorlatinib 100 mg once daily (n = 25) or crizotinib 250 mg twice daily (n = 23). The primary end point was progression-free survival assessed by blinded independent central review. Secondary end points included objective and intracranial responses assessed by blinded independent central review and safety. Results: At the data cutoff of September 20, 2021, median progression-free survival was not reached with lorlatinib and 11.1 months with crizotinib (hazard ratio = 0.36). Objective response rate was 72.0% with lorlatinib and 52.2% with crizotinib. For patients with baseline brain metastases, intracranial response rate was 100.0% versus 28.6% with lorlatinib versus crizotinib. Nine patients in the lorlatinib group received more than or equal to 1 subsequent anticancer systemic therapy, with ALK tyrosine kinase inhibitor as the most common first subsequent therapy. The safety profile was consistent with that reported previously, with no new safety signals. Conclusions: This updated analysis in the Japanese population revealed prolonged benefits of lorlatinib over crizotinib in patients with treatment-naive advanced ALK-positive NSCLC with and those without brain metastases.
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- 2024
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25. Effectiveness and Safety of Immune Checkpoint Inhibitors Alone or in Combination With Chemotherapy in Pulmonary Sarcomatoid Carcinoma
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Daisuke Hazama, MD, PhD, Kenji Nakahama, MD, PhD, Hiroaki Kodama, MD, Akito Miyazaki, MD, Koichi Azuma, MD, PhD, Yosuke Kawashima, MD, Yuki Sato, MD, Kentaro Ito, MD, Yoshimasa Shiraishi, MD, Keita Miura, MD, Takayuki Takahama, MD, PhD, Satoshi Oizumi, MD, PhD, Yoshinobu Namba, MD, Satoshi Ikeda, MD, PhD, Hiroshige Yoshioka, MD, PhD, Asuka Tsuya, MD, PhD, Yuichiro Yasuda, MD, PhD, Yoshiki Negi, MD, PhD, Ayako Hara, MD, Michihito Toda, MD, PhD, and Motoko Tachihara, MD, PhD
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Pulmonary sarcomatoid carcinoma ,Immune checkpoint inhibitors ,Real-world data ,Lung cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction: Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer associated with poor prognosis and resistance to conventional chemotherapy. Immune checkpoint inhibitors (ICIs), alone or in combination with chemotherapy, were found to have clinical benefits in PSC in recent studies. Nevertheless, because these studies included a small number of patients owing to disease rarity, larger studies are needed to evaluate the effectiveness and safety of ICI-based therapy for PSC. Methods: This multicenter retrospective study evaluated patients with ICI-naive advanced or metastatic PSC who were treated with ICI-based therapy at 25 hospitals in Japan. Results: A total of 124 patients were evaluated. The overall response rate, median progression-free survival (PFS), and median overall survival (OS) were 59.0%, 10.5 months, and 32.8 months, respectively. The PFS and OS rates at 24 months were 35.3% and 51.5%, respectively. Programmed death-ligand 1 expression, concomitant chemotherapy, and the treatment line were not significantly associated with PFS or OS. Immune-related adverse events (irAEs) were observed in 70 patients (56.5%), including 30 (24.2%) with grade 3 to 5 events. Patients with mild irAEs (grades 1–2) had longer PFS and OS than did those with severe (grades 3–5) or no irAEs. In a multivariate analysis, any-grade irAEs and the absence of liver metastases were independently associated with PFS, whereas any-grade irAEs and Eastern Cooperative Oncology Group performance status less than or equal to 1 were independently associated with OS. Conclusions: ICI-based therapy was found to have promising effectiveness in patients with advanced or metastatic PSC, regardless of programmed death-ligand 1 expression, concomitant chemotherapy, or treatment line.
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- 2024
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26. Don't Forget the Exception! : Considering Robustness Changes to Identify Design Problems.
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Anderson Oliveira, João Lucas Correia, Leonardo da Silva Sousa, Wesley K. G. Assunção, Daniel Coutinho, Alessandro F. Garcia 0001, Willian Nalepa Oizumi, Caio Barbosa, Anderson G. Uchôa, and Juliana Alves Pereira
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- 2023
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27. Forecast and Numerical Simulation Studies on Meso/Micro-scale High-Impact Weathers Using High-Performance Computing in Japan
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Saito, Kazuo, Kawabata, Takuya, Seko, Hiromu, Miyoshi, Takemasa, Duc, Le, Oizumi, Tsutao, Kunii, Masaru, Chen, Guixing, Ito, Kosuke, Ito, Junshi, Yokota, Sho, Mashiko, Wataru, Kobayashi, Kenichiro, Fukui, Shin, Tochimoto, Eigo, Amemiya, Arata, Maejima, Yasumitsu, Honda, Takumi, Niino, Hiroshi, Satoh, Masaki, and Park, Seon Ki, editor
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- 2023
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28. Evaluation of the radiofrequency identification lung marking system: a multicenter study in Japan
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Miyahara, So, Waseda, Ryuichi, Ueda, Yuichirou, Yutaka, Yojiro, Date, Hiroshi, Suzuki, Jun, Oizumi, Hiroyuki, Goto, Masashi, Nakagawa, Tatsuo, Kojima, Fumitsugu, Takenaka, Masaru, Tanaka, Fumihiro, and Sato, Toshihiko
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- 2023
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29. A secular radiographic change around uncemented humeral stem after shoulder arthroplasty – more than 8 years follow-up
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Honoki, Keigo, Suenaga, Naoki, Oizumi, Naomi, Yamane, Shintaro, Yoshioka, Chika, Hisada, Yukiyoshi, and Matsuhashi, Tomoya
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- 2024
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30. Factors associated with subjective shoulder function preoperatively and postoperatively after arthroscopic rotator cuff repair
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Ito, Yu, Ishida, Tomoya, Matsumoto, Hisashi, Yamaguchi, Shota, Ito, Hideki, Suenaga, Naoki, Oizumi, Naomi, Yoshioka, Chika, Yamane, Shintaro, Hisada, Yukiyoshi, and Matsuhashi, Tomoya
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- 2024
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31. Effectiveness and Safety of Immune Checkpoint Inhibitors Alone or in Combination With Chemotherapy in Pulmonary Sarcomatoid Carcinoma
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Hazama, Daisuke, Nakahama, Kenji, Kodama, Hiroaki, Miyazaki, Akito, Azuma, Koichi, Kawashima, Yosuke, Sato, Yuki, Ito, Kentaro, Shiraishi, Yoshimasa, Miura, Keita, Takahama, Takayuki, Oizumi, Satoshi, Namba, Yoshinobu, Ikeda, Satoshi, Yoshioka, Hiroshige, Tsuya, Asuka, Yasuda, Yuichiro, Negi, Yoshiki, Hara, Ayako, Toda, Michihito, and Tachihara, Motoko
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- 2024
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32. Life History Evolution and Adaptive Stochastic Controls
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Oizumi, Ryo, Abu-Laban, Baha, Advisory Editor, Birkin, Mark, Advisory Editor, Poston Jr., Dudley L., Advisory Editor, Stillwell, John, Advisory Editor, Wahl, Hans-Werner, Advisory Editor, Deeg, D. J. H., Advisory Editor, and Oizumi, Ryo
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- 2022
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33. Application to External Stochasticity
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Oizumi, Ryo, Abu-Laban, Baha, Advisory Editor, Birkin, Mark, Advisory Editor, Poston Jr., Dudley L., Advisory Editor, Stillwell, John, Advisory Editor, Wahl, Hans-Werner, Advisory Editor, Deeg, D. J. H., Advisory Editor, and Oizumi, Ryo
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- 2022
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34. Linear Structured Population Based on SDE
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Oizumi, Ryo, Abu-Laban, Baha, Advisory Editor, Birkin, Mark, Advisory Editor, Poston Jr., Dudley L., Advisory Editor, Stillwell, John, Advisory Editor, Wahl, Hans-Werner, Advisory Editor, Deeg, D. J. H., Advisory Editor, and Oizumi, Ryo
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- 2022
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35. Non-linear Structured Population Models
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Oizumi, Ryo, Abu-Laban, Baha, Advisory Editor, Birkin, Mark, Advisory Editor, Poston Jr., Dudley L., Advisory Editor, Stillwell, John, Advisory Editor, Wahl, Hans-Werner, Advisory Editor, Deeg, D. J. H., Advisory Editor, and Oizumi, Ryo
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- 2022
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36. Deterministic and Stochastic Population Models
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Oizumi, Ryo, Abu-Laban, Baha, Advisory Editor, Birkin, Mark, Advisory Editor, Poston Jr., Dudley L., Advisory Editor, Stillwell, John, Advisory Editor, Wahl, Hans-Werner, Advisory Editor, Deeg, D. J. H., Advisory Editor, and Oizumi, Ryo
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- 2022
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37. Extraction method of design rationale from speech in design processes
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Ryo NAKAZAWA and Kazuya OIZUMI
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design rationale ,information sharing ,information extraction ,tf/idf ,design experiment ,natural language processing ,Mechanical engineering and machinery ,TJ1-1570 ,Engineering machinery, tools, and implements ,TA213-215 - Abstract
As products become large-scale and complex, manufacturing industry faces problems in communication between workers. Among the information to be communicated, design rationale, such as reasons for decided design and the process of consideration leading to the decisions, is rarely expressed in shared design data. This paper proposes a information extraction method of design rationale. While design are conducted, conversations are recorded. Recorded sounds are transcribed using the voice input functions in Google Docs. The transcribed data is analyzed by TF/IDF, which evaluates importance of each word in the script by its frequency and rarity. By extracting sentences that contains important words, it is assumed that most design rationales can be depicted. The proposed method was applied to the design of scissors. The case shows that the proposed method has potential for extracting design rationale.
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- 2023
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38. Comparison of SP263 and 22C3 immunohistochemistry PD-L1 assays for clinical efficacy of adjuvant atezolizumab in non-small cell lung cancer: results from the randomized phase III IMpower010 trial
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Enriqueta Felip, Hiroshi Tanaka, Silvia Novello, Hao Xu, Heather Wakelee, Barbara Gitlitz, Martin Reck, Wei Zou, Elizabeth Bennett, Mark McCleland, Caicun Zhou, Satoshi Oizumi, Anna Kryzhanivska, Virginia McNally, Marcus Ballinger, Meghna Das Thakur, Steven L McCune, John Hamm, Minu K Srivastava, Nasser Altorki, and Rüdiger Liersch
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background Tumor samples from the phase III IMpower010 study were used to compare two programmed death-ligand 1 (PD-L1) immunohistochemistry assays (VENTANA SP263 and Dako 22C3) for identification of PD-L1 patient subgroups (negative, positive, low, and high expression) and their predictive value for adjuvant atezolizumab compared with best supportive care (BSC) in resectable early-stage non-small cell lung cancer (NSCLC).Methods PD-L1 expression was assessed by the SP263 assay, which measured the percentage of tumor cells with any membranous PD-L1 staining, and the 22C3 assay, which scored the percentage of viable tumor cells showing partial or complete membranous PD-L1 staining.Results When examining the concordance at the PD-L1-positive threshold (SP263: tumor cell (TC)≥1%; 22C3: tumor proportion score (TPS)≥1%), the results were concordant between assays for 83% of the samples. Similarly, at the PD-L1–high cut-off (SP263: TC≥50%; 22C3: TPS≥50%), the results were concordant between assays for 92% of samples. The disease-free survival benefit of atezolizumab over BSC was comparable between assays for PD-L1-positive (TC≥1% by SP263: HR, 0.58 (95% CI: 0.40 to 0.85) vs TPS≥1% by 22C3: HR, 0.65 (95% CI: 0.45 to 0.95)) and PD-L1-high (TC≥50% by SP263: HR, 0.27 (95% CI: 0.14 to 0.53) vs TPS≥50% by 22C3: HR, 0.31 (95% CI: 0.16 to 0.60)) subgroups.Conclusions The SP263 and 22C3 assays showed high concordance and a comparable clinical predictive value of atezolizumab at validated PD-L1 thresholds, suggesting that both assays can identify patients with early-stage NSCLC most likely to experience benefit from adjuvant atezolizumab.Trial registration number NCT02486718.
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- 2023
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39. Lethal adulthood myelin breakdown by oligodendrocyte-specific Ddx54 knockout
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Hiroaki Oizumi, Yuki Miyamoto, Chika Seiwa, Masahiro Yamamoto, Nozomu Yoshioka, Seiichi Iizuka, Tomohiro Torii, Katsuya Ohbuchi, Kazushige Mizoguchi, Junji Yamauchi, and Hiroaki Asou
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Biological sciences ,Neuroscience ,Molecular neuroscience ,Science - Abstract
Summary: Multiple sclerosis (MS) is a leading disease that causes disability in young adults. We have previously shown that a DEAD-box RNA helicase Ddx54 binds to mRNA and protein isoforms of myelin basic protein (MBP) and that Ddx54 siRNA blocking abrogates oligodendrocyte migration and myelination. Herein, we show that MBP-driven Ddx54 knockout mice (Ddx54 fl/fl;MBP-Cre), after the completion of normal postnatal myelination, gradually develop abnormalities in behavioral profiles and learning ability, inner myelin sheath breakdown, loss of myelinated axons, apoptosis of oligodendrocytes, astrocyte and microglia activation, and they die within 7 months but show minimal peripheral immune cell infiltration. Myelin in Ddx54fl/fl;MBP-Cre is highly vulnerable to the neurotoxicant cuprizone and Ddx54 knockdown greatly impairs myelination in vitro. Ddx54 expression in oligodendrocyte-lineage cells decreased in corpus callosum of MS patients. Our results demonstrate that Ddx54 is indispensable for myelin homeostasis, and they provide a demyelinating disease model based on intrinsic disintegration of adult myelin.
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- 2023
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40. Midterm outcomes following humeral head replacement with rotator cuff reconstruction for cuff tear arthropathy in patients younger than 65 years of age
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Kawamata, Jun, Suenaga, Naoki, Oizumi, Naomi, Miyoshi, Naoki, and Sairyo, Koichi
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- 2023
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41. Lethal adulthood myelin breakdown by oligodendrocyte-specific Ddx54 knockout
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Oizumi, Hiroaki, Miyamoto, Yuki, Seiwa, Chika, Yamamoto, Masahiro, Yoshioka, Nozomu, Iizuka, Seiichi, Torii, Tomohiro, Ohbuchi, Katsuya, Mizoguchi, Kazushige, Yamauchi, Junji, and Asou, Hiroaki
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- 2023
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42. Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation
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Kaptoge, S, Seshasai, SRK, Sun, L, Walker, M, Bolton, T, Spackman, S, Ataklte, F, Willeit, P, Bell, S, Burgess, S, Pennells, L, Altay, S, Assmann, G, Ben-Shlomo, Y, Best, LG, Björkelund, C, Blazer, DG, Brenner, H, Brunner, EJ, Dagenais, GR, Cooper, JA, Cooper, C, Crespo, CJ, Cushman, M, D'Agostino, RB, Sr, Daimon, M, Daniels, LB, Danker, R, Davidson, KW, de Jongh, RT, Donfrancesco, C, Ducimetiere, P, Elders, PJM, Engström, G, Ford, I, Gallacher, I, Bakker, SJL, Goldbourt, U, de La Cámara, G, Grimsgaard, S, Gudnason, V, Hansson, PO, Imano, H, Jukema, JW, Kabrhel, C, Kauhanen, J, Kavousi, M, Kiechl, S, Knuiman, MW, Kromhout, D, Krumholz, HM, Kuller, LH, Laatikainen, T, Lowler, DA, Meyer, HE, Mukamal, K, Nietert, PJ, Ninomiya, T, Nitsch, D, Nordestgaard, BG, Palmieri, L, Price, JF, Ridker, PM, Sun, Q, Rosengren, A, Roussel, R, Sakurai, M, Salomaa, V, Schöttker, B, Shaw, JE, Strandberg, TE, Sundström, J, Tolonen, H, Tverdal, A, Verschuren, WMM, Völzke, H, Wagenknecht, L, Wallace, RB, Wannamethee, SG, Wareham, NJ, Wassertheil-Smoller, S, Yamagishi, K, Yeap, BB, Harrison, S, Inouye, M, Griffin, S, Butterworth, AS, Wood, AM, Thompson, SG, Sattar, N, Danesh, J, Di Angelantonio, E, Tipping, RW, Russell, S, Johansen, M, Bancks, MP, Mongraw-Chaffin, M, Magliano, D, Barr, ELM, Zimmet, PZ, Whincup, PH, Willeit, J, Leitner, C, Lawlor, DA, Elwood, P, Sutherland, SE, Hunt, KJ, Selmer, RM, Haheim, LL, Ariansen, I, Tybjaer-Hansen, A, Frikkle-Schmidt, R, Langsted, A, Lo Noce, C, Balkau, B, Bonnet, F, Fumeron, F, Pablos, DL, Ferro, CR, Morales, TG, Mclachlan, S, Guralnik, J, Khaw, KT, Holleczek, B, Stocker, H, Nissinen, A, Vartiainen, E, Jousilahti, P, Harald, K, Massaro, JM, Pencina, M, Lyass, A, Susa, S, Oizumi, T, Kayama, T, Chetrit, A, Roth, J, Orenstein, L, Welin, L, Svärdsudd, K, Lissner, L, Hange, D, Mehlig, K, Tilvis, RS, Dennison, E, Westbury, L, Norman, PE, Almeida, OP, Hankey, GJ, Hata, J, Shibata, M, Furuta, Y, Bom, MT, Rutters, F, Muilwijk, M, Kraft, P, Lindstrom, S, Turman, C, Kiyama, M, Kitamura, A, Gerber, Y, Salonen, JT, van Schoor, LN, van Zutphen, EM, Melander, O, Psaty, BM, Blaha, M, de Boer, IH, Kronmal, RA, Grandits, G, Shin, H-C, Albertorio, JR, Gillum, RF, Hu, FB, Humphries, S, Hill- Briggs, F, Vrany, E, Butler, M, Schwartz, JE, Iso, H, Amouyel, P, Arveiler, D, Ferrieres, J, Gansevoort, RT, de Boer, R, Kieneker, L, Trompet, S, Kearney, P, Cantin, B, Després, JP, Lamarche, B, Laughlin, G, McEvoy, L, Aspelund, T, Thorsson, B, Sigurdsson, G, Tilly, M, Ikram, MA, Dorr, M, Schipf, S, Fretts, AM, Umans, JG, Ali, T, Shara, N, Davey-Smith, G, Can, G, Yüksel, H, Özkan, U, Nakagawa, H, Morikawa, Y, Ishizaki, M, Njølstad, I, Wilsgaard, T, Mathiesen, E, Buring, J, Cook, N, Arndt, V, Rothenbacher, D, Manson, J, Tinker, L, Shipley, M, Tabak, AG, Kivimaki, M, Packard, C, Robertson, M, Feskens, E, and Geleijnse, M
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- 2023
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43. Recommendations for Developers Identifying Code Smells.
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Rafael Maiani de Mello, Roberto Oliveira 0003, Anderson G. Uchôa, Willian Nalepa Oizumi, Alessandro F. Garcia 0001, Baldoino Fonseca, and Fernanda de Mello
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- 2023
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44. Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial
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Höglinger, Günter U, Litvan, Irene, Mendonca, Nuno, Wang, Deli, Zheng, Hui, Rendenbach-Mueller, Beatrice, Lon, Hoi-Kei, Jin, Ziyi, Fisseha, Nahome, Budur, Kumar, Gold, Michael, Ryman, Davis, Florian, Hana, Investigators, Arise, Ahmed, Anwar, Aiba, Ikuko, Albanese, Alberto, Bertram, Kelly, Bordelon, Yvette, Bower, James, Brosch, Jared, Claassen, Daniel, Colosimo, Carlo, Corvol, Jean-Christophe, Cudia, Paola, Daniele, Antonio, Defebvre, Luc, Driver-Dunckley, Erika, Duquette, Antoine, Eleopra, Roberto, Eusebio, Alexandre, Fung, Victor, Geldmacher, David, Golbe, Lawrence, Grandas, Francisco, Hall, Deborah, Hatano, Taku, Honig, Lawrence, Hui, Jennifer, Kerwin, Diana, Kikuchi, Akio, Kimber, Thomas, Kimura, Takashi, Kumar, Rajeev, Ljubenkov, Peter, Lorenzl, Stefan, Ludolph, Albert, Mari, Zoltan, McFarland, Nikolaus, Meissner, Wassilios, Rivera, Pablo Mir, Mochizuki, Hidek, Morgan, John, Munhoz, Renato, Nishikawa, Noriko, O`Sullivan, John, Oeda, Tomoko, Oizumi, Hideki, Onodera, Osamu, Ory-Magne, Fabienne, Peckham, Elizabeth, Postuma, Ronald, Quattrone, Aldo, Quinn, Joseph, Ruggieri, Stefano, Sarna, Justyna, Schulz, Paul E, Slevin, John, Tagliati, Michele, Wile, Daryl, Wszolek, Zbigniew, Xie, Tao, and Zesiewicz, Theresa
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Brain Disorders ,Clinical Research ,Clinical Trials and Supportive Activities ,Patient Safety ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Neurological ,Administration ,Intravenous ,Aged ,Antibodies ,Monoclonal ,Humanized ,Double-Blind Method ,Female ,Humans ,Male ,Middle Aged ,Supranuclear Palsy ,Progressive ,Treatment Outcome ,tau Proteins ,Arise Investigators ,Neurology & Neurosurgery ,Clinical sciences - Abstract
BackgroundProgressive supranuclear palsy is a neurodegenerative disorder associated with tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of human tau. We assessed the safety and efficacy of tilavonemab for the treatment of progressive supranuclear palsy.MethodsWe did a phase 2, multicentre, randomised, placebo-controlled, double-blind study at 66 hospitals and clinics in Australia, Canada, France, Germany, Italy, Japan, Spain, and the USA. Participants (aged ≥40 years) diagnosed with possible or probable progressive supranuclear palsy who were symptomatic for less than 5 years, had a reliable study partner, and were able to walk five steps with minimal assistance, were randomly assigned (1:1:1) by interactive response technology to tilavonemab 2000 mg, tilavonemab 4000 mg, or matching placebo administered intravenously on days 1, 15, and 29, then every 28 days through to the end of the 52-week treatment period. Randomisation was done by the randomisation specialist of the study sponsor, who did not otherwise participate in the study. The sponsor, investigators, and participants were unaware of treatment allocations. The primary endpoint was the change from baseline to week 52 in the Progressive Supranuclear Palsy Rating Scale (PSPRS) total score in the intention-to-treat population. Adverse events were monitored in participants who received at least one dose of study drug. Prespecified interim futility criteria were based on a model-based effect size of 0 or lower when 60 participants had completed the 52-week treatment period and 0·12 or lower when 120 participants had completed the 52-week treatment period. This study is registered at ClinicalTrials.gov, number NCT02985879.FindingsBetween Dec 12, 2016, and Dec 31, 2018, 466 participants were screened, 378 were randomised. The study was terminated on July 3, 2019, after prespecified futility criteria were met at the second interim analysis. A total of 377 participants received at least one dose of study drug and were included in the efficacy and safety analyses (2000 mg, n=126; 4000 mg, n=125; placebo, n=126). Least squares mean change from baseline to week 52 in PSPRS was similar in all groups (between-group difference vs placebo: 2000 mg, 0·0 [95% CI -2·6 to 2·6], effect size 0·000, p>0·99; 4000 mg, 1·0 [-1·6 to 3·6], -0·105, p=0·46). Most participants reported at least one adverse event (2000 mg, 111 [88%]; 4000 mg, 111 [89%]; placebo, 108 [86%]). Fall was the most common adverse event (2000 mg, 42 [33%]; 4000 mg, 54 [43%]; placebo, 49 [39%]). Proportions of patients with serious adverse events were similar among groups (2000 mg, 29 [23%]; 4000 mg, 34 [27%]; placebo, 33 [26%]). Fall was the most common treatment-emergent serious adverse event (2000 mg, five [4%]; 4000 mg, six [5%]; placebo, six [5%]). 26 deaths occurred during the study (2000 mg, nine [7%]; 4000 mg, nine [7%]; placebo, eight [6%]) but none was drug related.InterpretationA similar safety profile was seen in all treatment groups. No beneficial treatment effects were recorded. Although this study did not provide evidence of efficacy in progressive supranuclear palsy, the findings provide potentially useful information for future investigations of passive immunisation using tau antibodies for progressive supranuclear palsy.FundingAbbVie Inc.
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- 2021
45. Hesperetin Ameliorates Inhibition of Neuronal and Oligodendroglial Cell Differentiation Phenotypes Induced by Knockdown of Rab2b, an Autism Spectrum Disorder-Associated Gene Product
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Yukino Kato, Remina Shirai, Katsuya Ohbuchi, Hiroaki Oizumi, Masahiro Yamamoto, Wakana Miyata, Tomoki Iguchi, Yoshihiro Mimaki, Yuki Miyamoto, and Junji Yamauchi
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Rab2b ,neuron ,oligodendrocyte ,neuronal marker ,myelination marker ,hesperetin ,Medicine ,Internal medicine ,RC31-1245 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Autism spectrum disorder (ASD) is a central nervous system (CNS) neurodevelopmental disorder that includes autism, pervasive developmental disorder, and Asperger’s syndrome. ASD is characterized by repetitive behaviors and social communication deficits. ASD is thought to be a multifactorial disorder with a range of genetic and environmental factors/candidates. Among such factors is the rab2b gene, although it remains unclear how Rab2b itself is related to the CNS neuronal and glial developmental disorganization observed in ASD patients. Rab2 subfamily members regulate intracellular vesicle transport between the endoplasmic reticulum and the Golgi body. To the best of our knowledge, we are the first to report that Rab2b positively regulates neuronal and glial cell morphological differentiation. Knockdown of Rab2b inhibited morphological changes in N1E-115 cells, which are often used as the neuronal cell differentiation model. These changes were accomplished with decreased expression levels of marker proteins in neuronal cells. Similar results were obtained for FBD-102b cells, which are used as the model of oligodendroglial cell morphological differentiation. In contrast, knockdown of Rab2a, which is another Rab2 family member not known to be associated with ASD, affected only oligodendroglial and not neuronal morphological changes. In contrast, treatment with hesperetin, a citrus flavonoid with various cellular protective effects, in cells recovered the defective morphological changes induced by Rab2b knockdown. These results suggest that knockdown of Rab2b inhibits differentiation in neuronal and glial cells and may be associated with pathological cellular phenotypes in ASD and that hesperetin can recover their phenotypes at the in vitro level at least.
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- 2023
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46. Relationship between hematoma-like tissue on the footprint and structural outcome of arthroscopic rotator cuff repair with a transosseous technique
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Jun Kawamata, MD, Naoki Suenaga, MD, PhD, and Naomi Oizumi, MD, PhD
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Rotator cuff tear ,Arthroscopic rotator cuff repair ,Hematoma ,Structural outcome ,Retear ,Surface-holding method ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Background: We have tried to create hematoma over the footprint site at the end of arthroscopic rotator cuff repair (ARCR) surgery, expecting to apply biochemical effects of the platelet-related factors. The purpose of this study was to investigate the presence of hematoma-like tissue (HLT) on postoperative magnetic resonance imaging, and to evaluate the relationship between the HLT and the structural outcomes of ARCR. Materials and methods: Twenty-five patients were reviewed with a mean age at surgery of 69.8 years (range, 52-85 years). Postoperative magnetic resonance imaging was performed at 1 week, 6-8 weeks, and >6 months postoperatively. Structural outcomes for the repaired cuff and thickness of HLT were evaluated on coronal T2-weighted images. Signal intensity of HLT was evaluated on coronal T2-weighted fat-suppressed images as the ratio compared to supraspinatus tendon intensity (HLT/SSP ratio). Results: Structural outcomes showed Sugaya type 1 in 12 shoulders, type 2 in 4, and type 3 in 9. HLT thickness was significantly thicker at 1 week and 6-8 weeks postoperatively in Sugaya type 1 patients than in type 3 patients (1 week; P = .014, 6-8 weeks; P 6 months; 1.2 ± 0.5), and differed significantly between >6 months and both 1 week and 6-8 weeks (P
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- 2023
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47. Correlation of suprascapular notch morphology with suprascapular nerve palsy: a 3D-computed tomography study
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Keigo Honoki, MD, Naoki Suenaga, MD, PhD, Naomi Oizumi, MD, PhD, Shintaro Yamane, MD, PhD, Chika Yoshioka, MD, PhD, Yukiyoshi Hisada, MD, Tomoya Matsuhashi, MD, PhD, Jun Kawamata, MD, and Yu Ito, PT, MSc
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Suprascapular notch ,Suprascapular nerve palsy ,Rengachary’s classification ,Morphology ,Three-dimensional CT ,Superior transverse scapular ligament ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Background: The morphology of the suprascapular (SS) notch is a very important factor in treatment of suprascapular nerve (SSN) palsy. Several studies have reported SS notch morphology in cadavers or using a three-dimensional computed tomography (3D-CT); however, none has reported the distribution of SS notch morphology according to the age group. In addition, the correlation between SS notch morphology and SSN palsy remains unclear. The purposes of this study were to investigate the morphological distribution of the SS notch by age group in a large population and to assess the relationship between SS notch morphology and SSN palsy. Methods: We studied the 3D-CT images of 1063 shoulders in 1009 patients (mean age, 60.8 years; age range, 14-96 years). There were 53 shoulders with SSN palsy and 1010 shoulders without SSN palsy. Morphology of the SS notch was classified by Rengachary’s classification (types I-VI). Shoulders with types I-IV were classified into the nonossified superior transverse scapular ligament (STSL) group (group N) and those with types V and VI into the ossified STSL group (group O). Results: The Rengachary’s classifications of the 1063 shoulders were as follows: type I: n = 113, 10.6%; type II: n = 313, 29.4%; type III: n = 383, 36.0%; type IV: n = 109, 10.3%; type V: n = 107, 10.0%; and type VI: n = 38, 3.6%. Mean age was significantly older in the ossified STSL group, and the age was
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- 2023
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48. Ensemble rainfall–runoff and inundation simulations using 100 and 1000 member rainfalls by 4D LETKF on the Kumagawa River flooding 2020
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Kenichiro Kobayashi, Le Duc, Takuya Kawabata, Atsushi Tamura, Tsutao Oizumi, Kazuo Saito, Daisuke Nohara, and Tetsuya Sumi
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1000 Ensemble ,4D LETKF ,Rainfall–runoff ,Storage function model ,Inundation ,Shallow water equation ,Geography. Anthropology. Recreation ,Geology ,QE1-996.5 - Abstract
Abstract This paper presents the 1000 ensemble flood simulations using ensemble rainfalls simulated by 4D LETKF. The number of ensemble rainfall members is large as 1000 compared to the operational rainfall products of two-digit numbers to avoid sampling errors in the three-dimensional meteorological simulation based on chaotic theory. Using the large data set, 1000 ensemble rainfall–runoff for dam catchments and high-resolution inundation simulations of large area are carried out focusing on the Kumagawa river catchment. Herewith, the comparisons were carried out with 21-member ensemble rainfalls of an operational forecast by Japan Meteorological Agency and 100-member 4D-LETKF ensemble rainfalls simulated independent of 1000-member 4D-LETKF. At the same time, the accuracy of selective 100-member ensembles out of 1000 members is investigated. As a result, although many previous research works show a large number of ensemble simulations are necessary for three-dimensional meteorological field, the number could be reduced in the catchment-average rainfall–runoff and 2.5-dimensional inundation simulations given that the rainfall prediction has a certain level of accuracy since improving the discharge prediction accuracy with lower dimension is sometimes possible by adjusting the horizontally/vertically integrated model parameters determined by topography and soil characteristics in advance against the observed rainfall. Also, the 1000 ensembles could be classified into several patterns in horizontally accumulated 2D rainfall field. Likewise, the flood flow moves toward the low elevation area and river; thus, the resultant 2.5-dimensional flood field does not show much variety as three-dimensional meteorological simulation. The paper summarizes these studies.
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- 2023
- Full Text
- View/download PDF
49. Combined basilar subsegmentectomy for intralobar sequestration via uniportal VATS: a case report
- Author
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Satoshi Takamori, Hiroyuki Oizumi, Jun Suzuki, and Satoshi Shiono
- Subjects
Intralobar pulmonary sequestration ,Subsegmentectomy ,Uniportal video-assisted thoracoscopic surgery ,Surgery ,RD1-811 - Abstract
Abstract Background Combined basilar subsegmentectomy via uniportal video-assisted thoracoscopic surgery is an extremely complex surgery. Moreover, no the existing reports describe the procedure and technique. Here, we present the technique of combined basilar subsegmentectomy that was successfully performed via uniportal video-assisted thoracoscopic surgery to treat intralobar pulmonary sequestration in an adult patient. Case presentation A 57-year-old man underwent surgery for oropharyngeal carcinoma. Preoperative computed tomography showed several cystic lesions in the right lower lobe. Subsequent enhanced computed tomography revealed an anomalous artery branching from the abdominal aorta and a normal pulmonary vein. The patient with diagnosed with Pryce type III intralobar pulmonary sequestration and underwent right S7 posterior + 10bc combined basilar segmentectomy via uniportal video-assisted thoracoscopic surgery. The postoperative course was uneventful, and the patient was discharged 4 days after surgery. At the 8-month follow-up, computed tomography showed no abnormalities. Conclusions We successfully performed combined basilar subsegmentectomy via uniportal video-assisted thoracoscopic surgery. This surgical approach is useful for the treatment of intralobar pulmonary sequestration occurring at the basal segment of the lung.
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- 2023
- Full Text
- View/download PDF
50. Electromyographic activities of glenohumeral joint muscles during shoulder forward flexion with isometric horizontal abduction loading
- Author
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Ito, Yu, Matsumoto, Hisashi, Ishida, Tomoya, Suenaga, Naoki, and Oizumi, Naomi
- Published
- 2023
- Full Text
- View/download PDF
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