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298 results on '"Okada, Katsuya"'

10. The Efficacy of Golimumab Against Non-Infectious Uveitis: A PRISMA-Compliant Systematic Review and Meta-Analysis.

Author

Okada, Katsuya, Zhou, Yi, Hashida, Noriyasu, Takagi, Tatsuya, and Tian, Yu-Shi

Subjects
*UVEITIS, *GOLIMUMAB, *VISUAL acuity, *IRIDOCYCLITIS, *SAMPLE size (Statistics)
Abstract

In this PRISMA-compliant systematic review and meta-analysis, we aimed to assess the efficacy of golimumab (GOL) against non-infectious uveitis (NIU). We included eight articles in the meta-analysis. The primary outcome was inflammation remission. Secondary outcomes were changes in the number of uveitis relapses/attacks, mean best-corrected visual acuity, central macular thickness, and systemic corticosteroid-sparing effects. In total, eight case series with 172 patients (43.6% female) were collected. Patients had 75% (95% CI: 56–87%) of remission; 42% (0.12–0.80) of patients showed improved visual acuity. The average central macular thickness decline was 38 μm (−56.51–18.54). The pooled results showed a significant decrease in the use of systemic corticosteroids. This study was limited by the use of non-RCT designs, limited sample sizes for outcomes, and heterogenetic underlying diseases. Our results suggest that GOL is effective against NIU. However, further evidence and analyses are required. (Funding: None; PROSPERO registration: CRD42021266214.) [ABSTRACT FROM AUTHOR]

Published
2023
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39. Aiming for a change of government

Author

Okada, Katsuya

Subjects
Japan -- Political aspects, Legislators -- Beliefs, opinions and attitudes, Political parties -- Japan, Political parties -- Analysis, Political reform -- Analysis, Regional focus/area studies, Democratic Party of Japan -- Officials and employees
Published
2008

43. Radiofrequency (RF)-Assisted Hepatectomy May Induce Severe Postoperative Liver Damage

Author

Miyazawa Mitsuo, Torii Takahiro, Otani Yoshihide, Toshimitsu Yasuko, Aikawa Masayasu, Okada Katsuya, Shinozuka Nozomi, and Koyama Isamu

Subjects
Male, medicine.medical_specialty, Carcinoma, Hepatocellular, medicine.medical_treatment, Blood Loss, Surgical, Catheter ablation, Chronic liver disease, medicine, Hepatectomy, Humans, Aged, biology, business.industry, Liver Neoplasms, Alanine Transaminase, Bilirubin, Perioperative, Middle Aged, medicine.disease, Ablation, Cardiac surgery, Surgery, Liver, Alanine transaminase, Catheter Ablation, biology.protein, Female, business, Abdominal surgery
Abstract

Radiofrequency (RF) ablation for the treatment of the section line prior to liver resection has been proposed as a way to reduce blood loss during hepatectomy. Our group compared hepatectomy with and without RF ablation to determine whether this technique actually reduces blood loss during liver resection and whether it affects the perioperative outcome. Of 151 patients who underwent a hepatectomy between January 2002 and October 2005 at the Division of Gastrointestinal Surgery in the Department of Surgery of Saitama Medical University, 48 who had a partial hepatectomy or resection of a portion of liver smaller than a single Couinaud segment were included in the study. Twenty patients who had RF-assisted hepatectomy [RF (+) group] and 28 patients who had hepatectomy without ablation [RF (-) group] were studied to compare the rates of intraoperative blood loss and the effects of RF ablation on the perioperative outcome. Intraoperative blood loss was significantly reduced in the RF (+) group. In contrast, the alanine aminotransferase activity in the RF (+) group was significantly elevated immediately after the operation. There was no significant difference in the incidence of postoperative complications between the groups, although bile leakage did occur in three RF (+) patients. Our results demonstrate that the RF ablation technique can be a useful way to reduce surgical blood loss. In view of its association with severe postoperative liver damage, the technique must be applied with caution. The danger may be especially relevant to patients with chronic liver disease and decreased liver reserve.

Published
2007

44. Fibrin glue closure for intractable pancreatic fistulae after pancreaticoduodenectomy

Author

Okamoto, Kojun, Koyama, Isamu, Hara, Kiyoka, Aikawa, Masayasu, Okada, Katsuya, Watanabe, Yukihiro, and Miyazawa, Mitsuo

Subjects
Fibrin Tissue Adhesive, Pancreas, Pancreaticoduodenectomy
Abstract

Context Treatment of pancreatic fistulae after pancreaticoduodenectomy is extremely important because it determines the patient's postoperative course. In particular, treatment of grade B cases should be conducted in a timely manner to avoid deterioration to grade C. Objective We report the successful treatment of six cases of postoperative intractable, grade B pancreatic fistulae, in which fistula closure was achieved through the use of tissue adhesive. Methods Six subjects presented at our hospital with grade B pancreatic fistulae after pancreaticoduodenectomy. In all cases, the drain amylase values were high immediately after the operation, and the replacement of the drain was enforced. Closure of the fistula was performed by pouring tissue adhesive into the fistula from the drain, after the fistula had been straightened. Results Closure of the fistula was achieved in all six cases at the first attempt. The average fistula length was 13.2 cm, the average volume of pancreatic fluid discharge just before treatment was 63.3 mL, the average amylase value in the drainage was 40,338.5 IU/L, and the subjects were discharged from hospital an average of 8.8 days after treatment. There were no recurrences after treatment. Conclusion Intractable pancreatic fistulae can be effectively treated using the tissue adhesive method. Image: Pancreatic fluid drainage., JOP. Journal of the Pancreas, Vol 16, No 1 (2015): January - p. 1-98

Published
2015

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