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6. Defining a learning curve for urology trainees to achieve renal access without complications in endoscopic combined intrarenal surgery.

Author

Yanase, Takahiro, Taguchi, Kazumi, Sugino, Teruaki, Sue, Yasuhito, Isogai, Masahiko, Hattori, Tatsuya, Chaya, Ryosuke, Okada, Tomoki, Kawase, Kengo, Unno, Rei, Hashimoto, Hiroya, Hamamoto, Shuzo, Ando, Ryosuke, Okada, Atsushi, and Yasui, Takahiro

Subjects
LEARNING curve, BODY mass index, OPERATIVE surgery, UNIVERSITY hospitals, ENDOSCOPIC surgery
Abstract

Objectives: There is a lack of data on the number of surgeries required for endoscopic combined intrarenal surgery (ECIRS). Accordingly, we aimed to identify the learning curve for ECIRS performed by multiple surgeons. Methods: We included 296 patients who underwent ECIRS at our university hospital between 2016 and 2021. A learning curve for percutaneous nephrolithotomy side was calculated considering urology‐resident surgeons. The learning curve was retrospectively analyzed for surgical time, renal puncture time, stone‐free rate, and complications and corrected for age, body mass index, stone size, computed tomography value, cumulative number of surgeries, and stone location. Results: This study included cases performed by 32 surgeons, including 30 residents and 2 attending surgeons. The median number of surgeries performed by the residents and attending surgeons prior to this study was 4.5 and 90, respectively. The median number of surgical procedures performed during the training period was seven. The surgical time of the residents decreased as the number of cases increased, reaching a median surgical time of 111 min for the attending surgeons after 16.4 cases. Renal puncture time was achieved in 20.1 cases. Complications related to renal access were observed in 13.0% (34 patients), Clavien–Dindo grade II in 1.9% (5 patients), and grade III or higher in 0.8% (2 patients). Comparing the first to fifth cases with the 21st and subsequent cases, the complication rate improved from 35% to 13%. Conclusion: Our study demonstrated that ECIRS training provided 16–20 cases with a learning curve to achieve acceptable surgical outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophages

Author

Okada, Tomoki, primary, Okada, Atsushi, additional, Aoki, Hiromasa, additional, Onozato, Daichi, additional, Kato, Taiki, additional, Takase, Hiroshi, additional, Ohshima, Shigeru, additional, Sugino, Teruaki, additional, Unno, Rei, additional, Taguchi, Kazumi, additional, Hamamoto, Shuzo, additional, Ando, Ryosuke, additional, Shimada, Issei S, additional, Hashita, Tadahiro, additional, Iwao, Takahiro, additional, Matsunaga, Tamihide, additional, and Yasui, Takahiro, additional

Published
2023
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11. Evaluation of Cytotoxicity of Hyaluronic Acid/Chitosan/Bacterial Cellulose-Based Membrane.

Author

Dechojarassri, Duangkamol, Okada, Tomoki, Tamura, Hiroshi, and Furuike, Tetsuya

Subjects
*HYALURONIC acid, *BACTERIAL cell walls, *CHITOSAN, *SCANNING electron microscopy, *ALGINIC acid
Abstract

Novel wound dressing materials are required to non-cytotoxic with a viable cell ratio of above 92%. Herein, the cytotoxicity of hyaluronic acid/chitosan/bacterial cellulose-based (BC(CS/HA)) membranes are evaluated and compared to that of alginate/chitosan/bacterial cellulose-based (BC(CS/Alg)) membranes was investigated. Multilayer membranes with up to ten CS/HA or CS/Alg layers were prepared using the layer-by-layer (LBL) method. Scanning electron microscopy showed that the diameters of the fibers in the BC(CS/Alg) and BC(CS/HA) membranes were larger than those in a BC membrane. The cytotoxicity was analyzed using BALB-3T3 clone A31 cells (mouse fibroblasts, 1 × 104 cells/well). The BC(CS/HA)5 and BC(CS/HA)10 membranes exhibited high biocompatibility, with the cell viabilities of 94% and 87% at 5 d, respectively, compared to just 82% for the BC(CS/Alg)5 and BC(CS/Alg)10 membranes with same numbers of layers. These results suggested that BC(CS/HA)5 is a promising material for wound dressings. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Efficacy of ultrasound monitoring during extracorporeal shock wave lithotripsy: A multi‐institutional propensity score‐matched study

Author

Isogai, Masahiko, primary, Hamamoto, Shuzo, additional, Kawase, Kengo, additional, Okada, Tomoki, additional, Hattori, Tatsuya, additional, Chaya, Ryosuke, additional, Hamakawa, Takashi, additional, Sugino, Teruaki, additional, Taguchi, Kazumi, additional, Umemoto, Yukihiro, additional, Okada, Atsushi, additional, and Yasui, Takahiro, additional

Published
2022
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14. MP05-04 DISCOVERY OF DRUGS THAT PROMOTE THE PHAGOCYTIC ABILITY OF MACROPHAGES TO CALCIUM OXALATE CRYSTALS USING THE FDA-APPROVED DRUG LIBRARY

Author

Okada, Atsushi, primary, Takase, Hiroshi, additional, Isogai, Masahiko, additional, Okada, Tomoki, additional, Hattori, Tatsuya, additional, Chaya, Ryosuke, additional, Kawase, Kengo, additional, Tanaka, Yutaro, additional, Kato, Taiki, additional, Sugino, Teruaki, additional, Unno, Rei, additional, Taguchi, Kazumi, additional, Hamamoto, Shuzo, additional, Ando, Ryosuke, additional, Hashita, Tadahiro, additional, Tozawa, Keiichi, additional, Matsunaga, Tamihide, additional, Kohri, Kenjiro, additional, and Yasui, Takahiro, additional

Published
2022
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16. MP41-12 EFFECTIVENESS OF VIRTUAL REALITY SIMULATION OF RENAL PUNCTURE FOR ENDOSCOPIC-COMBINED INTRARENAL SURGERY

Author

Okada, Atsushi, primary, Ohashi, Kazuya, additional, Noda, Yusuke, additional, Okada, Tomoki, additional, Chaya, Ryosuke, additional, Kawase, Kengo, additional, Kato, Taiki, additional, Taguchi, Kazumi, additional, Hamamoto, Shuzo, additional, Tozawa, Keiichi, additional, Kohri, Kenjiro, additional, and Yasui, Takahiro, additional

Published
2022
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19. MP06-17 THE USEFULNESS OF ULTRASOUND MONITORING DURING EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY

Author

Isogai, Masahiko, primary, Hamamoto, Shuzo, additional, Hattori, Tatsuya, additional, Chaya, Ryosuke, additional, Okada, Tomoki, additional, Kawase, Kengo, additional, Kato, Taiki, additional, Taguchi, Kazumi, additional, Kobayashi, Takahiro, additional, Okada, Atsushi, additional, Umemoto, Yukihiro, additional, Tozawa, Keiichi, additional, and Yasui, Takahiro, additional

Published
2021
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20. MP07-04 STONE FORMATION BY ANALYSIS OF UROFLOW DYNAMICS IN THE RENAL PELVIS

Author

Kawase, Kengo, primary, Hamamoto, Shuzo, additional, Hattori, Shota, additional, chaya, Ryosuke, additional, Okada, Tomoki, additional, Tanaka, Yutaro, additional, Sugino, Takeru, additional, Unno, Rei, additional, Taguchi, Kazumi, additional, Ando, Ryosuke, additional, Okada, Atsushi, additional, Nakamura, Masanori, additional, and Yasui, Takahiro, additional

Published
2021
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22. MP18-18 URETEROSCOPY-ASSISTED VERSUS CONVENTIONAL ULTRASOUND-GUIDED RENAL ACCESS FOR MINIATURIZED ENDOSCOPIC COMBINED INTRARENAL SURGERY: A MULTICENTER COMPARATIVE STUDY

Author

Taguchi, Kazumi, primary, Yamashita, Shimpei, additional, Hamamoto, Shuzo, additional, Deguchi, Ryusuke, additional, Kawase, Kengo, additional, Okada, Tomoki, additional, Unno, Rei, additional, Kato, Taiki, additional, Ando, Ryosuke, additional, Okada, Atsushi, additional, Kohjimoto, Yasuo, additional, Hara, Isao, additional, and Yasui, Takahiro, additional

Published
2021
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23. MP18-17 COMPARISON OF SAFETY AND EFFICACY BETWEEN PRONE SPLIT-LEG AND MODIFIED SUPINE VALDIVIA POSITIONS IN ENDOSCOPIC COMBINED INTRARENAL SURGERY (ECIRS): A MULTI-INSTITUTIONAL ANALYSIS

Author

Hamamoto, Shuzo, primary, Okada, Shinsuke, additional, Inoue, Takaaki, additional, Taguchi, Kazumi, additional, Kawase, Kengo, additional, Okada, Tomoki, additional, Chaya, Ryosuke, additional, Hattori, Tatsuya, additional, Okada, Atsushi, additional, and Yasui, Takahiro, additional

Published
2021
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25. PD41-01 ROBOTIC-ASSISTED FLUOROSCOPIC-GUIDED RENAL PUNCTURE HAS COMPARABLE SURGICAL OUTCOMES WITH ULTRASOUND-GUIDED IN ENDOSCOPIC COMBINED INTRARENAL SURGERY: A RANDOMIZED CONTROLLED TRIAL

Author

Taguchi, Kazumi, primary, Hamamoto, Shuzo, additional, Sue, Yasuhito, additional, Kobayakawa, Yuki, additional, Hattori, Tatsuya, additional, Okada, Tomoki, additional, Chaya, Ryosuke, additional, Sugino, Teruaki, additional, Kato, Taiki, additional, Okada, Atsushi, additional, and Yasui, Takahiro, additional

Published
2021
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26. Ureteroscopy‐assisted puncture for ultrasonography‐guided renal access significantly improves overall treatment outcomes in endoscopic combined intrarenal surgery

Author

Taguchi, Kazumi, primary, Yamashita, Shimpei, additional, Hamamoto, Shuzo, additional, Deguchi, Ryusuke, additional, Kawase, Kengo, additional, Okada, Tomoki, additional, Kato, Taiki, additional, Ando, Ryosuke, additional, Okada, Atsushi, additional, Kohjimoto, Yasuo, additional, Hara, Isao, additional, and Yasui, Takahiro, additional

Published
2021
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28. A novel approach in creating nephrostomy using a double-lumen access sheath during endoscopic combined intrarenal surgery

Author

Unno, Rei, primary, Taguchi, Kazumi, additional, Hamamoto, Shuzo, additional, Hattori, Tatsuya, additional, Kawase, Kengo, additional, Okada, Tomoki, additional, Chaya, Ryosuke, additional, Tanaka, Yutaro, additional, Sugino, Teruaki, additional, Kato, Taiki, additional, Etani, Toshiki, additional, Ando, Ryosuke, additional, Okada, Atsushi, additional, and Yasui, Takahiro, additional

Published
2021
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30. Failure of endoscopic management of ureteral strictures is due to ureteroscopic lithotripsy as a cause and longer length of stricture

Author

Sugino, Teruaki, primary, Taguchi, Kazumi, additional, Hamamoto, Shuzo, additional, Okada, Tomoki, additional, Isogai, Masahiko, additional, Tanaka, Yutaro, additional, Unno, Rei, additional, Fujii, Yasuhiro, additional, Hamakawa, Takashi, additional, Ando, Ryosuke, additional, Okada, Atsushi, additional, and Yasui, Takahiro, additional

Published
2020
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34. PD07-10 USEFULNESS OF DETERMINATION OF RENAL PUNCTURE LINE IN ECIRS USING VIRTUAL REALITY

Author

Okada*, Atsushi, primary, Noda, Yusuke, additional, Ohashi, Kazuya, additional, Okada, Tomoki, additional, Chaya, Ryosuke, additional, Kawase, Kengo, additional, Kato, Taiki, additional, Taguchi, Kazumi, additional, Hamamoto, Shuzo, additional, Hirose, Yasujiro, additional, Tozawa, Keiichi, additional, Kohri, Kenjiro, additional, and Yasui, Takahiro, additional

Published
2020
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35. MP22-08 IMPACT OF PREOPERATIVE URETERAL STENTING ON ENDOSCOPIC FINDINGS

Author

Hamamoto*, Shuzo, primary, Okada, Shinsuke, additional, Inoue, Takaaki, additional, Okada, Tomoki, additional, Chaya, Ryosuke, additional, Kawase, Kengo, additional, Taguchi, Kazumi, additional, Okada, Atsushi, additional, Miura, Hiroyasu, additional, Matsuda, Tadashi, additional, and Yasui, Takahiro, additional

Published
2020
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36. PD15-09 THE IMPACT OF SWL HANDS-ON TRAINING ON MAINTAINING HIGH SUCCESS RATE AND IDENTIFICATION OF PERFORMANCE IMPROVEMENT FACTORS

Author

Okada*, Atsushi, primary, Okada, Tomoki, additional, Chaya, Ryosuke, additional, Kawase, Kengo, additional, Tanaka, Yutaro, additional, Sugino, Teruaki, additional, Unno, Rei, additional, Banno, Rika, additional, Kato, Taiki, additional, Taguchi, Kazumi, additional, Hamamoto, Shuzo, additional, Ando, Ryosuke, additional, Tozawa, Keiichi, additional, Kohri, Kenjiro, additional, and Nagoya, Takahiro Yasui, additional

Published
2020
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38. Comparison of the safety and efficacy between the prone split‐leg and Galdakao‐modified supine Valdivia positions during endoscopic combined intrarenal surgery: A multi‐institutional analysis.

Author

Hamamoto, Shuzo, Okada, Shinsuke, Inoue, Takaaki, Taguchi, Kazumi, Kawase, Kengo, Okada, Tomoki, Chaya, Ryosuke, Hattori, Tatsuya, Okada, Atsushi, Matsuda, Tadashi, and Yasui, Takahiro

Subjects
SUPINE position, URINARY tract infections, COMPUTED tomography, ANATOMICAL variation, URINARY organs
Abstract

Objectives: To evaluate the safety and efficacy of the prone split‐leg and the Galdakao‐modified supine Valdivia positions during endoscopic combined intrarenal surgery. Methods: A multi‐institutional, retrospective cohort study was conducted between January 2014 and December 2018. The stone‐free and complication rates were compared between the prone split‐leg and the Galdakao‐modified supine Valdivia positions. Anatomical variations were evaluated using contrast‐enhanced computed tomography imaging. Results: In total, 118 and 100 patients underwent endoscopic combined intrarenal surgery in the prone split‐leg and Galdakao‐modified supine Valdivia positions, respectively. Renal punctures in the prone split‐leg position were predominantly executed through the lower calyces (78.0%), whereas those in the Galdakao‐modified supine Valdivia position were primarily performed through the middle calyces (64.0%; P < 0.001). Surgical duration in the prone split‐leg position was significantly shorter than that in the Galdakao‐modified supine Valdivia position (106.5 vs 126.0 min; P = 0.0459). There were no significant differences in the stone‐free rate between the two positions (78.8% vs 76.0%; P = 0.629). Incidences of urinary tract injury (P = 0.033) and febrile urinary tract infection (23.7% vs 10.0%; P = 0.011) in the prone split‐leg position were significantly higher than that in the Galdakao‐modified supine Valdivia position. The tilt of the major renal axis was significantly greater in the prone position than the corresponding values in the oblique position (19.4° vs 8.5°; P = 0.019). Conclusions: Anatomical variation might result in the differences of renal puncture calyx. Endoscopic combined intrarenal surgery in the Galdakao‐modified supine Valdivia position may bring equal stone‐free status, with a longer surgical time but fewer complications including febrile urinary tract infection and urinary tract injury than the prone split‐leg position. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Low Geriatric Nutritional Risk Index as a Poor Prognostic Marker for Second-Line Pembrolizumab Treatment in Patients with Metastatic Urothelial Carcinoma: A Retrospective Multicenter Analysis

Author

Etani, Toshiki, primary, Naiki, Taku, additional, Sugiyama, Yosuke, additional, Nagai, Takashi, additional, Iida, Keitaro, additional, Noda, Yusuke, additional, Shimizu, Nobuhiko, additional, Tasaki, Yoshihiko, additional, Mimura, Yoshihisa, additional, Okada, Tomoki, additional, Banno, Rika, additional, Kubota, Hiroki, additional, Hamamoto, Shuzo, additional, Ando, Ryosuke, additional, Kawai, Noriyasu, additional, and Yasui, Takahiro, additional

Published
2020
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46. Risk Factors for Failure of Endoscopic Management of Stone-related Ureteral Strictures.

Author

Teruaki Sugino, Kazumi Taguchi, Shuzo Hamamoto, Tomoki Okada, Masahiko Isogai, Yutaro Tanaka, Rei Unno, Yasuhiro Fujii, Takashi Hamakawa, Ryosuke Ando, Atsushi Okada, Takahiro Yasui, Sugino, Teruaki, Taguchi, Kazumi, Hamamoto, Shuzo, Okada, Tomoki, Isogai, Masahiko, Tanaka, Yutaro, Unno, Rei, and Fujii, Yasuhiro

Subjects
*URETERIC obstruction, *ENDOSCOPIC surgery, *LASER lithotripsy, *TREATMENT effectiveness, *HYDRONEPHROSIS, *STENOSIS, *RETROSPECTIVE studies, *LITHOTRIPSY, *URINARY calculi, *URETEROSCOPY, *DISEASE complications
Abstract

Purpose: To investigate factors determining the outcomes of endoscopic management for stone-related ureteral stricture.Materials and Methods: Data of patients who underwent endoscopic surgery for ureteral stricture due to stones from January 2016 to April 2020 were retrospectively analyzed. We compared cases successfully treated with endoscopic surgery with cases that resulted in failure. We focused on factors associated with treatment success, including cause and length of stricture, methods of stricture treatment, surgical time, and duration of hydronephrosis before the treatment. Treatment success was defined as improvement in hydronephrosis status.Results: Nineteen patients were treated for stone-related ureteral stricture. Hydronephrosis was successfully improved in 12 patients (63.2%). Seven patients with failed endoscopic management had ureteroscopic lithotripsy- related stricture, whereas 3/12 (25.0%) patients with ureteroscopic lithotripsy-related stricture and 7/12 (58.3%) patients with impacted stone-related stricture were successfully treated by endoscopic management (P = .004). The prevalence of stricture length > 15 mm was significantly higher in the patients with failed management than in the patients with successful management (71.4 vs 16.6%, P = .046). Intraoperative endoscopic observation demonstrated that the mucosa of the ureteroscopic lithotripsy-related stricture had ischemic appearance with relatively long stricture length (P = 0.13) compared to the impacted stone-related stricture. No association was observed between treatment outcome and method of endoscopic management, including laser incision, balloon dilation, or both.Conclusion: Ureteroscopic lithotripsy as a cause and stricture length > 15 mm could affect the success rate of endoscopic management of ureteral stricture. In such cases, reconstructive management should probably be considered in the early stages. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Impact of pelvicalyceal anatomical variation on surgical outcomes of endoscopic combined intrarenal surgery.

Author

Kawase K, Hamamoto S, Taguchi K, Inoue T, Okada S, Sugino T, Isogai M, Torii K, Yanase T, Okada T, Hattori T, Chaya R, Okada A, and Yasui T

Abstract

Objectives: The objective of this work is to investigate the impact of the pelvicalyceal anatomical system (PCS) on calyceal stone formation and surgical outcomes of endoscopic combined intrarenal surgery (ECIRS) for renal and/or proximal ureteral stones with a diameter >15 mm., Patients and Methods: PCS was classified as Type I (single pelvis) or Type II (divided pelvis) according to the simple anatomical Takazawa classification. Using prospectively collected data from January 2016 to April 2020, 219 patients were retrospectively reviewed. After excluding patients who underwent a staged procedure, had hydronephrosis greater than grade 2, prior nephrostomy tubes, and failed to access the renal collecting system, 115 patients (Type I: 81, Type II: 34) were included, and the distribution of calyceal stones and surgical outcomes in ECIRS were compared between Types I and II PCS., Results: The median number of renal stone calyces in the Type II group was significantly more than that in the Type I group ( p  = 0.016). In particular, the Type II group possessed more upper stone calyces. Multivariate logistic regression analysis revealed that Type II PCS was associated with an increased odds ratio (OR) for the presence of upper stone calyces (OR: 2.93, p  = 0.018). The stone-free (SF) status at 1 month after surgery, confirmed by abdominal plain radiography, was significantly higher in the Type I group compared with that in Type II (67.9% vs. 39.4%, respectively; p  = 0.006). The requirement for additional surgical interventions was significantly higher in the Type II group compared with that in Type I (35.4% vs. 7.4%, respectively; p  < 0.001). Multivariate analysis revealed that the number of stone calyces (OR: 4.26; p  = 0.001) and Type II PCS (OR: 3.43; p  = 0.009) were independent predictors of residual stones after ECIRS., Conclusion: We first revealed that the anatomic properties of PCS play a role in both upper calyceal stone formation and in the success of the ECIRS procedure. Because the SF rate in Type II PCS was significantly lower than that in Type I PCS, additional percutaneous nephrolithotomy tracts might be required, even for ECIRS., Competing Interests: The authors declare that they have no conflict of interest., (© 2022 The Authors. BJUI Compass published by John Wiley & Sons Ltd on behalf of BJU International Company.)

Published
2022
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