Search

Your search keyword '"Okamoto, Motoi"' showing total 250 results
Start Over Author "Okamoto, Motoi"
250 results on '"Okamoto, Motoi"'

1. Comprehensive behavioral study of C57BL/6.KOR-ApoEshl mice

Author

Ueno Hiroshi, Takahashi Yu, Murakami Shinji, Wani Kenta, Miyazaki Tetsuji, Matsumoto Yosuke, Okamoto Motoi, and Ishihara Takeshi

Subjects
apolipoprotein, behavior, behavioral test, central nervous system, mouse, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Apolipoprotein E (ApoE) is associated with Alzheimer’s disease (AD) and cognitive dysfunction in elderly individuals. There have been extensive studies on behavioral abnormalities in ApoE-deficient (Apoeshl) mice, which have been described as AD mouse models. Spontaneously hyperlipidemic mice were discovered in 1999 as ApoE-deficient mice due to ApoE gene mutations. However, behavioral abnormalities in commercially available Apoeshl mice remain unclear. Accordingly, we aimed to investigate the behavioral abnormalities of Apoeshl mice.

Published
2023
Full Text
View/download PDF

4. Mice can recognise water depths and will avoid entering deep water

Author

Ueno Hiroshi, Takahashi Yu, Suemitsu Shunsuke, Murakami Shinji, Kitamura Naoya, Wani Kenta, Matsumoto Yosuke, Okamoto Motoi, and Ishihara Takeshi

Subjects
anxiety-like behaviours, mouse, phobia, water, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Rodents are averse to bodies of water, and this aversion has been exploited in experiments designed to study stress in mice. However, a few studies have elucidated the characteristics of murine water aversion. In this study, we investigated how mice behave in and around areas filled with water. Using variants of the open field test that contained pools of water at corners or sides of the field, we recorded the movements of mice throughout the field under various conditions. When the water was 8 mm deep, the mice explored the water pool regardless of whether an object was placed within it, but when the water was 20 mm deep, the mice were less willing to enter it. When the mice were placed on a dry area surrounded by 3 mm-deep water, they explored the water, but when they were surrounded by 8 mm-deep water, they stayed within the dry area. Our results indicate that mice exhibit exploratory behaviours around water, they can recognise water depths and avoid unacceptably deep water, and their willingness to enter water may be reduced by situational anxiety. Our experimental method could be used to investigate water-related anxiety-like behaviours in mice.

Published
2022
Full Text
View/download PDF

32. Caffeine inhalation effects on locomotor activity in mice

Author

Ueno, Hiroshi, primary, Takahashi, Yu, additional, Suemitsu, Shunsuke, additional, Murakami, Shinji, additional, Kitamura, Naoya, additional, Wani, Kenta, additional, Matsumoto, Yosuke, additional, Okamoto, Motoi, additional, and Ishihara, Takeshi, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results