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331 results on '"Okamura, R."'

4. Molecular biomarkers to predict response to immunotherapy in endometrial cancer patients enrolled on the profile related evidence determining individualized cancer therapy (PREDICT) trial (NCT02478931) at the UC San Diego Moores Cancer Center

Author

Charo, L.M., primary, Okamura, R., additional, Eskander, R.N., additional, Binder, P.S., additional, Ramkissoon, S., additional, Lee, S., additional, Danziger, N., additional, Kato, S., additional, Saenz, C.C., additional, Plaxe, S.C., additional, Kurzrock, R., additional, Elvin, J.A., additional, and McHale, M.T., additional

Published
2020
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7. Neoadjuvant chemoradiotherapy with/without lateral lymph node dissection for low rectal cancer: Which patients can benefit?

Author

Nishizaki, D., primary, Hida, K., additional, Sumii, A., additional, Sakai, Y., additional, Konishi, T., additional, Akagi, T., additional, Yamaguchi, T., additional, Akiyoshi, T., additional, Fukuda, M., additional, Yamamoto, S., additional, Maruyama, S., additional, Okajima, M., additional, Miyakura, Y., additional, Okamura, R., additional, Arizono, S., additional, Yamamoto, M., additional, Kawada, K., additional, Morita, S., additional, and Watanabe, M., additional

Published
2019
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19. Abstract P3-13-04: Skeletal related Events and Bone Metastasis Patients with Breast Cancer in Japan. A Retrospective Study

Author

Yamashiro, H, primary, Takada, M, additional, Imai, S, additional, Yamauch, A, additional, Tsuyuki, S, additional, Inamoto, T, additional, Matsutani, Y, additional, Sakata, S, additional, Wada, Y, additional, Okamura, R, additional, Harada, T, additional, Tanaka, F, additional, Moriguchi, Y, additional, Kato, H, additional, Higashide, S, additional, Kan, N, additional, Yoshibayashi, H, additional, Suwa, H, additional, Okino, T, additional, Nakayama, I, additional, Ichinose, Y, additional, Yamagami, K, additional, Hashimoto, T, additional, Nakatani, E, additional, Nagata, Y, additional, Kudo, Y, additional, and Toi, M, additional

Published
2012
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20. Suppression of polymorphonuclear leucocyte chemotaxis by Pseudomonas aeruginosa elastase in vitro: a study of the mechanisms and the correlation with ring abscess in pseudomonal keratitis

Author

Ijiri, Y., Matsumoto, K., Kamata, R., Nishino, N., Okamura, R., Kambara, T., and Yamamoto, T.

Subjects
Keratitis, animal structures, Receptors, Peptide, Neutrophils, Hydrolysis, Metalloendopeptidases, hemic and immune systems, Models, Biological, Receptors, Formyl Peptide, Abscess, N-Formylmethionine Leucyl-Phenylalanine, Chemotaxis, Leukocyte, Bacterial Proteins, Culture Media, Conditioned, Pseudomonas aeruginosa, Humans, Pseudomonas Infections, Receptors, Immunologic, Research Article
Abstract

Bacteria, or the culture supernatants of an elastase non-producing strain of Pseudomonas aeruginosa, elicited a chemotactic response from polymorphonuclear leucocytes (PMN) in vitro. The chemoattractive capacity was diminished under the presence of Boc-Phe-Leu-Phe-Leu-Phe, a receptor antagonist of N-formyl-Met-Leu-Phe (fMLP) which is a bacterial chemotactic peptide to PMN. This indicated that the chemoattractant derived from Pseudomonas aeruginosa was a fMLP-like molecule(s). In contrast, culture supernatants of an elastase producing strain of Pseudomonas aeruginosa produced negligible chemotactic response from PMN. Indeed, an inhibitory effect of the culture supernatants or of purified Pseudomonas aeruginosa elastase (PAE) on PMN chemotaxis was observed when fMLP was used as a chemoattractant. Another fMLP-induced function of PMN, respiratory burst activation, was also diminished by pretreatment of PMN with PAE. PAE hydrolysed fMLP at the Met-Leu bond and diminished the chemoattractant capacity. In addition, a receptor analysis with fML-3H-P demonstrated a decrease in numbers of fMLP receptors on PMN without changing the dissociation constant values after the treatment of the cells with PAE. In the primary structure of the fMLP receptor previously reported, a preferential amino acid sequence for cleavage by PAE was identified in what was believed to be an extracellular portion of the receptor molecule. These results suggested that PAE could diminish PMN infiltration in response to Pseudomonas aeruginosa in vivo by cleavage of the fMLP-like pseudomonal chemotactic ligand and the receptors on PMN.

Published
1994

34. Grating test of contrast sensitivity in patients with Minamata disease.

Author

Mukuno, K, Ishikawa, S, and Okamura, R

Abstract

Thirty cases of Minamata disease caused by methyl mercury poisoning with the lesion mainly at the occipital cortex were selected and their spatial contrast sensitivity of vision was examined by the Arden grating chart. At the same time their visual acuity, visual field, and visual evoked cortical potential (VECP) were also investigated. In all cases the results of the Arden test indicated abnormality. Poor results were obtained at higher frequencies of the gratings. VECP elicited by grating pattern reversal stimulus was undertaken in 12 cases out of the 30. The results revealed abnormality almost equal to that shown by the Arden test. Seven out of the 12 cases showed no VECP response. The other 5, giving a response, showed abnormality: when the size of the grating became smaller at higher frequencies, the VECP paused or was not recorded, whereas at low frequencies it was recorded. This finding was in good agreement or was not recorded, whereas at low frequencies it was recorded. This finding was in good agreement with the results of the Arden test. Visual acuity and visual field tests were less sensitive in detecting abnormality. The Arden chart is a sensitive clinical tool for patients with lesions at the cerebral cortex. Furthermore, the test can be used for screening patients who may have come in contrast with organic mercury. [ABSTRACT FROM PUBLISHER]

Published
1981

38. Pathogenic capacity of proteases from Serratia marcescens and Pseudomonas aeruginosa and their suppression by chicken egg white ovomacroglobulin

Author

Molla, A, Matsumura, Y, Yamamoto, T, Okamura, R, and Maeda, H

Abstract

The pathogenicities of three proteases from Serratia marcescens, two proteases from Pseudomonas aeruginosa, and one thermolysin from Bacillus stearothermophilus were examined. All proteases tested caused acute liquefactive necrosis of the cornea and descemetocele formation in guinea pig eyes after intrastromal injection, with the exception of the 60-kilodalton protease from S. marcescens, which produced only an opaque lesion. When injected into guinea pig skin, the protease also enhanced vascular permeability, which was followed by edema formation. The permeability-enhancing activity of the proteases increased in parallel with the concentration of the enzymes. When tested in vitro for its effect on these bacterial proteases, chicken egg white ovomacroglobulin (ovoM) inhibited the enzymatic activity of all the proteases after a short incubation period at an enzyme/inhibitor ratio (molar) of 1:1 to 1:4 or at a lower concentration after a longer incubation period. Such treatment of the proteases with chicken egg white ovoM before injection intrastromally into the eyes or intradermally into the clipped flanks of guinea pigs protected the cornea from destruction or completely prevented the permeability reaction and edema formation. No inhibitory effects of plasma protease inhibitors against these bacterial proteases were noted. Since the proteases are critical in the pathogenic processes caused by the bacteria, these results suggest a beneficial effect of ovoM against bacterial infections.

Published
1987
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39. Purification and characterization of four proteases from a clinical isolate of Serratia marcescens kums 3958

Author

Matsumoto, K, Maeda, H, Takata, K, Kamata, R, and Okamura, R

Abstract

Four distinct proteases were purified to homogeneity from culture filtrates of Serratia marcescens kums 3958, a fresh isolate from a patient with a severe corneal ulcer. Purification was achieved by ammonium sulfate precipitation, DEAE-cellulose ion-exchange chromatography, and Sephadex gel filtration chromatography. The proteases were differentiated from each other by polyacrylamide gel electrophoresis with or without sodium dodecyl sulfate and by immunodiffusion in agarose gels. The molecular weights of these purified proteases were estimated to be 56 X 10(3), 60 X 10(3), and 73 X 10(3) (hereafter designated 56K, 60K, and 73K proteases, respectively). The 73K protease was separated into 73Ka and 73Kb upon isoelectricfocusing. The isoelectric points of the 56K (major) and 60K, 73Ka, and 73Kb proteases (minors) were approximately 5.3, 4.4, 5.8, and 7.3, respectively. Both 56K and 60K enzymes were completely inactivated by EDTA at pH 5.0 and were reactivated by zinc ion; thus, they are metalloenzymes, whereas 73K (73Ka and 73Kb) enzymes appear to be thiol proteases. Carbohydrate, cysteine, and cystine were not detected in the 56K and 60K proteases. Amino acid compositions, partial amino acid sequence, and enzymological and immunological properties revealed that these four enzymes are distinct from each other.

Published
1984
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40. Association of Adenovirus Type 8 with Epidemic Keratoconjunctivitis: Special Reference to the Infantile Form of the Disease

Author

MITSUI, Y., HANNA, L., HANABUSA, J., MINODA, R., OGATA, S., KURIHARA, H., OKAMURA, R., and MIURA, M.

Abstract

Infection with adenovirus Type 8 appears to be regularly associated with clinical epidemic keratoconjunctivitis (EKC).1-5 Jawetz et al.1 isolated the prototype of this virus in 1955. Since that time, isolations of nine strains have been reported4 to June, 1957, eight from clinical EKC and one from an unidentified conjunctivitis which may have been an infantile form of EKC. Six of the nine strains were isolated from EKC in Japan, five by us and one by Tanaka.5In the present study answers were sought to the following questions: 1. What is the best technique for isolation of adenovirus Type 8? 2. How often can it be isolated from clinical EKC? 3. How long after onset can it be isolated from active cases of EKC? 4. Is "infantile EKC" also regularly associated with infection by adenovirus Type 8? (The infantile form of EKC was first described by Mitsui

Published
1959
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42. Novel Trinuclear Trihydride Complexes of Ruthenium Having a Triply Bridging Borylene Ligand, {(η<SUP>5</SUP>-C<INF>5</INF>Me<INF>5</INF>)Ru}<INF>3</INF>(μ-H)<INF>3</INF>(μ<INF>3</INF>-BX) (X = H, CN, OMe, OEt). Synthesis, Structure Determination, and Reaction with Benzothiophene

Author

Okamura, R., Tada, K., Matsubara, K., Oshima, M., and Suzuki, H.

Abstract

The triruthenium hexahydride complex [{(η5-C5Me5)Ru}3(μ-H)6](BF4) reacted with NaBH3X (X = H, CN) to yield the novel trinuclear μ3-borylene complex {(η5-C5Me5)Ru}3(μ-H)3(μ3-BX), and the μ3-BH derivative was converted into a μ3-B(OR) analogue (R = Me, Et) upon treatment with MeOH and EtOH, respectively. In the reaction of the μ3-BH analogue with benzothiophene, a μ3-thiaruthenacyclohexadiene complex formed via carbon−sulfur bond cleavage was isolated, and its structure was determined by an X-ray diffraction study.

Published
2001

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