Search

Your search keyword '"Okiror, William"' showing total 22 results
Start Over Author "Okiror, William"
22 results on '"Okiror, William"'

2. Nutritional supplementation in children with severe pneumonia in Uganda and Kenya (COAST-Nutrition): a phase 2 randomised controlled trial

Author

Kiguli, Sarah, Olupot-Olupot, Peter, Hamaluba, Mainga, Giallongo, Elisa, Thomas, Karen, Alaroker, Florence, Opoka, Robert O., Tagoola, Abner, Oyella, Shela, Nalwanga, Damalie, Nabawanuka, Eva, Okiror, William, Nakuya, Margaret, Amorut, Denis, Muhindo, Rita, Ayub Mpoya, Mnjalla, Hellen, Oguda, Emmanuel, Williams, Thomas N., Harrison, David A., Rowan, Kathy, Briend, Andre, and Maitland, Kathryn

Published
2024
Full Text
View/download PDF

5. Legume-supplemented feed for children hospitalised with severe malnutrition: A Phase II trial

Author

Walsh, Kevin, primary, Kiosia, Agklinta, additional, Olupot-Oupot, Peter, additional, Alaroker, Florence, additional, Okiror, William, additional, Nakuya, Margaret, additional, Ssenyondo, Tonny, additional, Amorut, Denis, additional, Okalebo, Charles Bernard, additional, Muhindo, Rita, additional, Mpoya, Ayub, additional, George, Elizabeth C, additional, Frost, Gary, additional, and Maitland, Kathryn, additional

Published
2024
Full Text
View/download PDF

7. Low Malaria Parasite Density is Associated with Severe Malaria in Children in Eastern Uganda: a cross sectional study

Author

Egiru, Emma Isaiah Eregu, primary, NAMAYANJA, CATE, additional, Tegu, Crispus, additional, Chebet, Martin, additional, Okiror, William, additional, Ongodia, Paul, additional, Okalebo, Charles Bernard, additional, Muhindo, Rita, additional, Abongo, Grace, additional, Paasi, George, additional, Francis, Okello, additional, Okibure, Ambrose, additional, Mukunya, David, additional, and Olupot-Olupot, Peter, additional

Published
2023
Full Text
View/download PDF

8. PARIST study protocol: a phase I/II randomised, controlled clinical trial to assess the feasibility, safety and effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria

Author

Paasi, George, primary, Okalebo, Charles Benard, additional, Ongodia, Paul, additional, Namayanja, Cate, additional, Eregu, Egiru Emma Isaiah, additional, Abongo, Grace, additional, Olupot, Moses, additional, Amorut, Denis, additional, Muhindo, Rita, additional, Okiror, William, additional, Ndila, Carolyne, additional, and Olupot-Olupot, Peter, additional

Published
2023
Full Text
View/download PDF

9. Modifying gut integrity and microbiome in children with severe acute malnutrition using legume-based feeds (MIMBLE II): A Phase II trial

Author

Walsh, Kevin, primary, Kiosa, Agklinta, additional, Olupot-Olupot, Peter, additional, Okiror, William, additional, Ssenyond, Tonny, additional, Okalebo, Charles Bernard, additional, Muhindo, Rita, additional, Mpoya, Ayub, additional, George, Elizabeth C, additional, Frost, Gary, additional, and Maitland, Kathryn, additional

Published
2023
Full Text
View/download PDF

10. Unusual Clinical Spectra of Childhood Severe Malaria During Malaria Epidemic in Eastern Uganda: A Prospective Study

Author

Namayanja, Cate, primary, Eregu, Egiru Emma Isaiah, additional, Ongodia, Paul, additional, Okalebo, Charles Benard, additional, Okiror, William, additional, Okello, Francis, additional, Okibure, Ambrose, additional, Paasi, George, additional, Kakungulu, Hellen, additional, Grace, Abongo, additional, Muhindo, Rita, additional, Banks, Duncan, additional, Martin, Chebet, additional, Taylor-Robinson, Simon, additional, and Olupot-Olupot, Peter, additional

Published
2023
Full Text
View/download PDF

11. Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial

Author

Olupot-Olupot, Peter, primary, Okiror, William, additional, Mnjalla, Hellen, additional, Muhindo, Rita, additional, Uyoga, Sophie, additional, Mpoya, Ayub, additional, Williams, Thomas N, additional, terHeine, Rob, additional, Burger, David M, additional, Urban, Britta, additional, Connon, Roisin, additional, George, Elizabeth C, additional, Gibb, Diana M, additional, Walker, A Sarah, additional, and Maitland, Kathryn, additional

Published
2023
Full Text
View/download PDF

12. Nutritional Supplementation in African Children with Severe Pneumonia: A Phase II Randomised Controlled Trial

Author

Kiguli, Sarah, primary, Olupot Oluput, Peter, additional, Hamaluba, Mainga, additional, Giallongo, Elisa, additional, Thomas, Karen, additional, Alaroker, Florence, additional, Opoka, Robert O., additional, Tagoola, Abner, additional, Oyella, Shela, additional, Nalwanga, Damalie, additional, Nabawanuka, Eva, additional, Okiror, William, additional, Nakuya, Margeret, additional, Aromut, Denis, additional, Muhindo, Rita, additional, Mpoya, Ayub, additional, Mnjella, Hellen, additional, Oguda, Emmanuel, additional, Williams, Thomas N., additional, Harrison, David A., additional, Rowan, Kathryn, additional, Briend, Andre, additional, Maitland, Kathryn, additional, and Group, COAST Trial, additional

Published
2023
Full Text
View/download PDF

13. A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa

Author

Olupot‐Olupot, Peter, primary, Connon, Roisin, additional, Kiguli, Sarah, additional, Opoka, Robert O., additional, Alaroker, Florence, additional, Uyoga, Sophie, additional, Nakuya, Margret, additional, Okiror, William, additional, Nteziyaremye, Julius, additional, Ssenyondo, Tonny, additional, Nabawanuka, Eva, additional, Kayaga, Juliana, additional, Williams Mukisa, Cynthia, additional, Amorut, Denis, additional, Muhindo, Rita, additional, Frost, Gary, additional, Walsh, Kevin, additional, Macharia, Alexander W., additional, Gibb, Diana M., additional, Walker, A. Sarah, additional, George, Elizabeth C., additional, Maitland, Kathryn, additional, and Williams, Thomas N., additional

Published
2022
Full Text
View/download PDF

14. Voluntary HIV Counseling and Testing (VCT): Knowledge, attitudes, hinderances, and practices of adults seeking treatment at Gulu Regional Referral Hospital on the spread of HIV in Northern Uganda. A cross-sectional study

Author

Aduk, Mary Assumpta, primary, Atama, Isaac Malon, additional, Dayo, Leonard, additional, Kizza, Cissy Namujuzi, additional, Musinguzi, Brian, additional, Ndomeirwe, Pretty Precious, additional, Okiror, William, additional, Senteza, Ignatius, additional, Wanjiku, Grace Wachira, additional, Ikoona, Eric Nzirakaindi, additional, and Kitara, David Lagoro, additional

Published
2021
Full Text
View/download PDF

15. Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial

Author

Olupot-Olupot, Peter, primary, Okiror, William, additional, Mnjalla, Hellen, additional, Muhindo, Rita, additional, Uyoga, Sophie, additional, Mpoya, Ayub, additional, Williams, Thomas N, additional, terHeine, Rob, additional, Burger, David M, additional, Urban, Britta, additional, Connon, Roisin, additional, George, Elizabeth C, additional, Gibb, Diana M, additional, Walker, A Sarah, additional, and Maitland, Kathryn, additional

Published
2021
Full Text
View/download PDF

17. Characterising demographics, knowledge, practices and clinical care among patients attending sickle cell disease clinics in Eastern Uganda

Author

Olupot-Olupot, Peter, primary, Wabwire, Ham, additional, Ndila, Carolyne, additional, Adong, Ruth, additional, Ochen, Linus, additional, Amorut, Denis, additional, Abongo, Grace, additional, Okalebo, Charles B., additional, Akello, Sarah Rachael, additional, Oketcho, Joy B., additional, Okiror, William, additional, Asio, Sarah, additional, Odiit, Amos, additional, Alaroker, Florence, additional, Nyutu, Gideon, additional, Maitland, Kathryn, additional, and Williams, Thomas N., additional

Published
2020
Full Text
View/download PDF

18. The Children's Oxygen Administration Strategies Trial (COAST)

Author

Kiguli, Sarah, primary, Olupot Oluput, Peter, additional, Hamaluba, Mainga, additional, Thomas, K., additional, Alaroker, Florence, additional, Opoka, Robert O., additional, Tagoola, Abner, additional, Bandika, Victor, additional, Mpoya, Ayub, additional, Mnjella, Hellen, additional, Nabawanuka, Eva, additional, Okiror, William, additional, Nakuya, Margeret, additional, Aromut, Denis, additional, Engoru, Charles, additional, Oguda, Emmanuel, additional, Fraser, J. F., additional, Williams, Thomas N., additional, Harrison, D. A, additional, Rowan, Kathryn, additional, Maitland, Kathryn, additional, and Group, COAST Trial, additional

Published
2020
Full Text
View/download PDF

19. The Children's Oxygen Administration Strategies Trial (COAST)

Author

Maitland, Kathryn, primary, Kiguli, Sarah, additional, Olupot Oluput, Peter, additional, Hamaluba, Mainga, additional, Thomas, Karen, additional, Alaroker, Florence, additional, Opoka, Robert O., additional, Tagoola, Abner, additional, Bandika, Victor, additional, Mpoya, Ayub, additional, Mnjella, Hellen, additional, Nabawanuka, Eva, additional, Okiror, William, additional, Nakuya, Margaret, additional, Aromut, Denis, additional, Engoru, Charles, additional, Oguda, Emmanuel, additional, Fraser, John F, additional, Williams, Thomas N., additional, Harrison, David A., additional, and Rowan, Kathy, additional

Published
2020
Full Text
View/download PDF

20. Modifying Intestinal Integrity and MicroBiome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial

Author

Walsh, Kevin, primary, Calder, Nuala, additional, Olupot-Olupot, Peter, additional, Ssenyondo, Tonny, additional, Okiror, William, additional, Okalebo, Charles Bernard, additional, Muhindo, Rita, additional, Mpoya, Ayub, additional, Holmes, Elaine, additional, Marchesi, Julian, additional, Delamare de la Villenaise de Chenevarin, Gael, additional, Frost, Gary, additional, and Maitland, Kathryn, additional

Published
2018
Full Text
View/download PDF

21. Unusual clinical spectra of childhood severe malaria during malaria epidemic in eastern Uganda: a prospective study

Author

Namayanja, Cate, Eregu, Egiru Emma Isaiah, Ongodia, Paul, Okalebo, Charles Benard, Okiror, William, Okello, Francis, Okibure, Ambrose, Paasi, George, Kakungulu, Hellen, Grace, Abongo, Muhindo, Rita, Banks, Duncan, Martin, Chebet, Taylor-Robinson, Simon, Olupot-Olupot, Peter, Namayanja, Cate, Eregu, Egiru Emma Isaiah, Ongodia, Paul, Okalebo, Charles Benard, Okiror, William, Okello, Francis, Okibure, Ambrose, Paasi, George, Kakungulu, Hellen, Grace, Abongo, Muhindo, Rita, Banks, Duncan, Martin, Chebet, Taylor-Robinson, Simon, and Olupot-Olupot, Peter

Abstract

Background In sub-Saharan Africa (SSA), malaria remains a public health problem despite recent reports of declining incidence. Severe malaria is a multiorgan disease with wide-ranging clinical spectra and outcomes that have been reported to vary by age, geographical location, transmission intensity over time. There are reports of recent malaria epidemics or resurgences, but few data, if any, focus on the clinical spectrum of severe malaria during epidemics. This describes the clinical spectrum and outcomes of childhood severe malaria during the disease epidemic in Eastern Uganda. Methods This prospective cohort study from October 1, 2021, to September 7, 2022, was nested within the ‘Malaria Epidemiological, Pathophysiological and Intervention studies in Highly Endemic Eastern Uganda’ (TMA2016SF-1514-MEPIE Study) at Mbale Regional Referral Hospital, Uganda. Children aged 60 days to 12 years who at admission tested positive for malaria and fulfilled the clinical WHO criteria for surveillance of severe malaria were enrolled on the study. Follow-up was performed until day 28. Data were collected using a customized proforma on social demographic characteristics, clinical presentation, treatment, and outcomes. Laboratory analyses included complete blood counts, malaria RDT (SD BIOLINE Malaria Ag P.f/Pan, Ref. 05FK60-40-1) and blood slide, lactate, glucose, blood gases and electrolytes. In addition, urinalysis using dipsticks (Multistix® 10 SG, SIEMENS, Ref.2300) at the bedside was done. Data were analysed using STATA V15.0. The study had prior ethical approval. Results A total of 300 participants were recruited. The median age was 4.6 years, mean of 57.2 months and IQR of 44.5 months. Many children, 164/300 (54.7%) were under 5 years, and 171/300 (57.0%) were males. The common clinical features were prostration 236/300 (78.7%), jaundice in 205/300 (68.3%), severe malarial anaemia in 158/300 (52.7%), black water feve

22. M odifying I ntestinal Integrity and M icro B iome in Severe Malnutrition with Le gume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial.

Author

Walsh K, Calder N, Olupot-Olupot P, Ssenyondo T, Okiror W, Okalebo CB, Muhindo R, Mpoya A, Holmes E, Marchesi J, Delamare de la Villenaise de Chenevarin G, Frost G, and Maitland K

Abstract

Background: Changes in intestinal mucosal integrity and gut microbial balance occur in severe acute malnutrition (SAM), resulting in treatment failure and adverse clinical outcomes (gram-negative sepsis, diarrhoea and high case-fatality). Transient lactose intolerance, due to loss of intestinal brush border lactase, also complicates SAM, thus milk based feeds may not be optimal for nutritional rehabilitation. Since the gut epithelial barrier can be supported by short chain fatty acids, derived from microbiota fermentation by particular fermentable carbohydrates, we postulated that an energy-dense nutritional feed comprising of legume-based fermentable carbohydrates, incorporated with lactose-free versions of standard World Health Organization (WHO) F75/F100 nutritional feeds will enhance epithelial barrier function in malnourished children, reduce and promote resolution of diarrhoea and improve overall outcome. Methods: We will investigate in an open-label trial in 160 Ugandan children with SAM, defined by mid-upper arm circumference <11.5cm and/or presence of kwashiorkor. Children will be randomised to a lactose-free, chickpea-enriched feed containing 2 kcal/ml, provided in quantities to match usual energy provision (experimental) or WHO standard treatment F75 (0.75 kcal/ml) and F100 (1 kcal/ml) feeds on a 1:1 basis, conducted at Mbale Regional Referral Hospital nutritional rehabilitation unit. The primary outcomes are change in MUAC at day 90 and survival to day 90. Secondary outcomes include: i) moderate to good weight gain (>5 g/kg/day), ii) de novo development of diarrhoea (>3 loose stools/day), iii) time to diarrhoea resolution (if >3 loose stools/day), and iv) time to oedema resolution (if kwashiorkor) and change in intestinal biomarkers (faecal calprotectin). Discussion: We hypothesize that, if introduced early in the management of malnutrition, such lactose-free, fermentable carbohydrate-based feeds, could safely and cheaply improve global outcome by reducing lactose intolerance-related diarrhoea, improving mucosal integrity and enhancing immunity, and limiting the risk of systemic infection and associated broad-spectrum antibiotic resistance. Registration: ISRCTN 10309022., Competing Interests: No competing interests were disclosed.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results