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2. Epidemiology and Outcomes of Neonatal Meningitis: Results of the Turkish Neo-Meningitis Nationwide Study

Author

Oncel, Mehmet Yekta, Cizmeci, Mehmet N., Karadag-Oncel, Eda, Elvan-Tuz, Aysegul, Canpolat, Fuat Emre, Akin, Mustafa Ali, Uslu, Sinan, Cetinkaya, Merih, Erdeve, Omer, Koc, Esin, Kadioglu-Simsek, Gulsum, Buyuktiryaki, Mehmet, Karal, Ferhan Iren, Kiray-Bas, Evrim, Dincer, Emre, Ustun, Huseyin, Varal, Ipek Guney, Dogan, Pelin, Celik, Mahmut, Erol, Elif, Demirel, Nihal, Tokgoz-Cuni, Betul, Okulu, Emel, Lacinbala, Turan, Hirfanoglu, Ibrahim Murat, Tas, Melda, Takci, Sahin, Kocatepe, Gaye, Zenciroglu, Aysegul, Bidev, Duygu, Ozdemir, Ramazan, Gokce, Ismail Kursad, Okur, Nilufer, Yurttutan, Sadik, Konak, Murat, Aykanat, Alper, Arslanoglu, Sertac, Deliloglu, Burak, Yazici, Aybuke, Kulali, Ferit, Gunes, Damla, Yangin-Ergon, Ezgi, Akcan, Baris, Arayici, Sema, Dilek, Mustafa, Sahin, Suzan, Engur, Defne, Yilmaz, Nisel, Yilmaz, Dilek, and Elmali, Ferhan

Published
2024
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3. An Update on Patent Ductus Arteriosus and What is Coming Next

Author

Erdeve, Omer, Division of Neonatology, Department of Pediatrics, Okulu, Emel, Singh, Yogen, Sindelar, Richard, Oncel, Mehmet Yekta, Terrin, Gianluca, Boscarino, Giovanni, Bulbul, Ali, Sallmon, Hannes, Atasay, Begum, Ovali, Fahri, Clyman, Ronald I, Division of Neonatology, Loma Linda University School of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Department of Women’s and Children’s Health, Uppsala University, Division of Neonatology, Buca Seyfi Demirsoy Training and Research Hospital, Department of Maternal and Child Health, University of Roma La Sapienza, Division of Neonatology, Department of Pediatrics University of Health Science, Department of Congenital Heart Disease/Pediatric Cardiology, Charité–Universitätsmedizin Berlin and Deutsches Herzzentrum Berlin, and Department of Pediatrics and Cardiovascular Research Institute, University of California San Francisco

Subjects
Paediatrics, Biomedical and Clinical Sciences, Infant Mortality, Cardiovascular, Pediatric, Preterm, Low Birth Weight and Health of the Newborn, Perinatal Period - Conditions Originating in Perinatal Period, patent ductus arteriosus, preterm, conservative, medical, surgical, treatment
Abstract

Patent ductus arteriosus is the most common cardiovascular condition in preterm infants. There is a significant uncertainty about when and how to close ductus arteriosus in preterm infants due to a high spontaneous closure rate even in very immature preterm infants. Diagnosis and management of patent ductus arteriosus remain a challenge for both neonatologists and pediatric cardiologists. Researchers have tried to define a balance between an expectant approach and active treatment in selected infants. This review aimed to focus on the pathophysiology and management of patent ductus arteriosus and to make suggestions about approaches that might eliminate the association of morbidities with patent ductus arteriosus.

Published
2022

4. Assessing the impact of a multidimensional approach and an 8-component bundle in reducing incidences of ventilator-associated pneumonia across 35 countries in Latin America, Asia, the Middle East, and Eastern Europe

Author

Rosenthal, Victor Daniel, Jin, Zhilin, Yin, Ruijie, Sahu, Suneeta, Rajhans, Prasad, Kharbanda, Mohit, Nair, Pravin K., Mishra, Shakti Bedanta, Chawla, Rajesh, Arjun, Rajalakshmi, Sandhu, Kavita, Rodrigues, Camilla, Dongol, Reshma, Myatra, Sheila Nainan, Mohd-Basri, Mat Nor, Chian-Wern, Tai, Bhakta, Arpita, Bat-Erdene, Ider, Acharya, Subhash P., Alvarez, Gustavo Andres, Moreno, Lina Alejandra Aguilar, Gomez, Katherine, da Jimenez-Alvarez, Luisa Fernanda, Henao-Rodas, Claudia Milena, Valderrama-Beltran, Sandra Liliana, Zuniga-Chavarria, Maria Adelia, Aguirre-Avalos, Guadalupe, Hernandez-Chena, Blanca Estela, Sassoe-Gonzalez, Alejandro, Aleman-Bocanegra, Mary Cruz, Villegas-Mota, Maria Isabel, De Moros, Daisy Aguilar, Castaneda-Sabogal, Alex, Carreazo, Nilton Yhuri, Alkhawaja, Safaa, Agha, Hala Mounir, El-Kholy, Amani, Abdellatif-Daboor, Mohammad, Dursun, Oguz, Okulu, Emel, Havan, Merve, Yildizdas, Dincer, Deniz, Suna Secil Ozturk, Guclu, Ertugrul, Hlinkova, Sona, Ikram, Aamer, Tao, Lili, Omar, Abeer Aly, Elahi, Naheed, Memish, Ziad A., Petrov, Michael M., Raka, Lul, Janc, Jarosław, Horhat-Florin, George, Medeiros, Eduardo Alexandrino, Salgado, Estuardo, Dueñas, Lourdes, Coloma, Monica, Perez, Valentina, and Brown, Eric Christopher

Published
2024
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6. Short, medium, and long deferral of umbilical cord clamping compared with umbilical cord milking and immediate clamping at preterm birth: a systematic review and network meta-analysis with individual participant data

Author

Seidler, Anna Lene, Libesman, Sol, Hunter, Kylie E, Barba, Angie, Aberoumand, Mason, Williams, Jonathan G, Shrestha, Nipun, Aagerup, Jannik, Sotiropoulos, James X, Montgomery, Alan A, Gyte, Gillian M L, Tarnow-Mordi, William O, El-Naggar, Walid, Carlo, Waldemar A, Datta, Vikram, Lago, Victor, Sundaram, Venkataseshan, Manoj, Varanattu C, Debray, Thomas P A, Sahoo, Tanushree, Trongkamonthum, Tanai, Hooper, Stuart B, Dias, Sofia, Pratesi, Simone, Badurdeen, Shiraz, Hosono, Shigeharu, Belk, Sheila S, Shekhar, Shashank, Chamnanvanakij, Sangkae, Arsan, Saadet, Knol, Ronny, Simes, Robert John, Riley, Richard D, Pongmee, Pharuhad, Davis, Peter G, Andersson, Ola, Dipak, Niraj K, Nasef, Nehad, Allam, Nahed E, Mangla, Mukul K, Meyer, Michael P, March, Melissa I, Kluckow, Martin, Goya, Maria, de Veciana, Margarita, Gharehbaghi, Manizheh M, Robledo, Kristy P, Murphy, Kellie E, Wallace, Kedra, Fairchild, Karen D, Josephsen, Justin B, Mercer, Judith S, Dorling, Jon S, Kattwinkel, John, Liu, Jiang-Qin, Nour, Islam, Atia, Hytham, Liley, Helen G, Rabe, Heike, Al-Wassia, Heidi K, Carroli, Guillermo, Polglase, Graeme R, Ram Mohan, Govindu, Dempsey, Eugene M, Okulu, Emel, Blank, Douglas A, Chawla, Deepak, Ruangkit, Chayatat, Tanprasertkul, Chamnan, De Paco Matallana, Catalina, Backes, Carl H, Schwaberger, Bernhard, Urlesberger, Berndt, KC, Ashish, te Pas, Arjan B, Katheria, Anup C, Thukral, Anu, George, Anu A, Webster, Angela C, Kugelman, Amir, Tan, Aidan C, Kumar, Aditi, Garg, Aashim, Duley, Lelia, and Askie, Lisa M

Published
2023
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7. Deferred cord clamping, cord milking, and immediate cord clamping at preterm birth: a systematic review and individual participant data meta-analysis

Author

Seidler, Anna Lene, Aberoumand, Mason, Hunter, Kylie E, Barba, Angie, Libesman, Sol, Williams, Jonathan G, Shrestha, Nipun, Aagerup, Jannik, Sotiropoulos, James X, Montgomery, Alan A, Gyte, Gillian M L, Garg, Aashim, Kumar, Aditi, Tan, Aidan C, Kugelman, Amir, Webster, Angela C, George, Anu A, Thukral, Anu, Katheria, Anup C, te Pas, Arjan B, KC, Ashish, Urlesberger, Berndt, Schwaberger, Bernhard, Backes, Carl H, De Paco Matallana, Catalina, Tanprasertkul, Chamnan, Ruangkit, Chayatat, Chawla, Deepak, Blank, Douglas A, Okulu, Emel, Dempsey, Eugene M, Ram Mohan, Govindu, Polglase, Graeme R, Carroli, Guillermo, Al-Wassia, Heidi K, Rabe, Heike, Liley, Helen G, Atia, Hytham, Nour, Islam, Liu, Jiang-Qin, Kattwinkel, John, Dorling, Jon S, Mercer, Judith S, Josephsen, Justin B, Fairchild, Karen D, Wallace, Kedra, Murphy, Kellie E, Robledo, Kristy P, Gharehbaghi, Manizheh M, de Veciana, Margarita, Goya, Maria, Kluckow, Martin, March, Melissa I, Meyer, Michael P, Mangla, Mukul K, Allam, Nahed E, Nasef, Nehad, Dipak, Niraj K, Andersson, Ola, Davis, Peter G, Pongmee, Pharuhad, Riley, Richard D, Simes, Robert John, Knol, Ronny, Arsan, Saadet, Shekhar, Shashank, Belk, Sheila S, Hosono, Shigeharu, Badurdeen, Shiraz, Pratesi, Simone, Dias, Sofia, Hooper, Stuart B, Sahoo, Tanushree, Debray, Thomas P A, Manoj, Varanattu C, Sundaram, Venkataseshan, Lago, Victor, Datta, Vikram, El-Naggar, Walid, Carlo, Waldemar A, Tarnow-Mordi, William O, Duley, Lelia, and Askie, Lisa M

Published
2023
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8. Prolonged Tracheal Intubation and the Association Between Patent Ductus Arteriosus and Bronchopulmonary Dysplasia: A Secondary Analysis of the PDA-TOLERATE trial

Author

Clyman, Ronald I, Kaempf, Joseph, Liebowitz, Melissa, Erdeve, Omer, Bulbul, Ali, Håkansson, Stellan, Lindqvist, Johanna, Farooqi, Aijaz, Katheria, Anup, Sauberan, Jason, Singh, Jaideep, Nelson, Kelly, Wickremasinghe, Andrea, Dong, Lawrence, Hassinger, Denise C, Aucott, Susan W, Hayashi, Madoka, Heuchan, Anne Marie, Carey, William A, Derrick, Matthew, Fernandez, Erika, Sankar, Meera, Leone, Tina, Perez, Jorge, Serize, Arturo, Investigators, the PDA-TOLERATE Trial, Fields, Scott, Whitten, Lora, Rogers, Stefanie, Okulu, Emel, Tunc, Gaffari, Ucar, Tayfun, Ünal, Ebru Türkoglu, Steen, Jane, Arnell, Kathy, Holtschlag, Sarah, Schreiber, Michael, Peters, Caryn, Gilmore, Maureen, McKay, Lorna, Carole, Dianne, Shaw, Annette, Harris, Malinda, Amsbaugh, Amy, Liedl, Lavonne M, Wolf, Sue, Groner, Avi, Kimball, Amy, Kim, Jae, Bridge, Renee, Knodel, Ellen, Weng, Chrissy, Barbosa, Magaly Diaz, Polin, Richard, Weindler, Marilyn, Noori, Shahab, Reese, Jeffrey, and Sun, Yao

Subjects
Paediatrics, Biomedical and Clinical Sciences, Pediatric, Preterm, Low Birth Weight and Health of the Newborn, Perinatal Period - Conditions Originating in Perinatal Period, Rare Diseases, Neonatal Respiratory Distress, Cardiovascular, Orphan Drug, Lung, Good Health and Well Being, Bronchopulmonary Dysplasia, Ductus Arteriosus, Patent, Female, Humans, Infant, Newborn, Intubation, Intratracheal, Male, Prospective Studies, Respiration, Artificial, Severity of Illness Index, Time Factors, PDA-TOLERATE Trial Investigators, bronchopulmonary dysplasia, patent ductus arteriosus, premature birth, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

In the PDA-TOLERATE trial, persistent (even for several weeks) moderate to large patent ductus arteriosus (PDA) was not associated with an increased risk of BPD when the infant required

Published
2021

9. Prospective cohort study of incidence and risk factors for Catheter-associated Urinary Tract Infections in 212 Intensive Care Units of nine Middle Eastern countries

Author

Jin, Zhilin, Yin, Ruijie, Brown, Eric Christopher, Shukla, Bhavarth, Lee, Brandon Hochahn, Abdulaziz-Alkhawaja, Safaa, Magray, Tahera Anwar, Agha, Hala Mounir, El-Sisi, Amal, El-Kholy, Amani Ali, Bayani, Victor, Daboor, Mohammad Abdellatif, Al-Ruzzieh, Majeda Afeef, Guclu, Ertugrul, Horoz, Ozden Ozgur, Kendirli, Tanil, Koksal, Iftihar, Memish, Ziad A, Olmez-Gazioglu, Esra, Dursun, Oguz, Kara, Tugce Tural, Eroglu, Ahmet, Havan, Merve, Deniz, Suna Secil Ozturk, Aktas, Gizem, Yildizdas, Dincer, Okulu, Emel, Kostekci, Yasemin Ezgi, Omar, Abeer Aly, and Rosenthal, Victor Daniel

Published
2023

10. Characteristics of continuous venovenous hemodiafiltration in the acute treatment of inherited metabolic disorders

Author

Eminoglu, Fatma Tuba, Öncül, Ümmühan, Kahveci, Fevzi, Okulu, Emel, Kraja, Elvis, Köse, Engin, and Kendirli, Tanil

Subjects
Metabolism, Inborn errors of -- Care and treatment, Health
Abstract

Background Continuous kidney replacement therapies (CKRT) have been reported to be an effective approach to removing toxic metabolites in inborn errors of metabolism (IEM). The present study evaluates efficiency and complications of CKRT in children with IEM. Methods Patients diagnosed with IEM who underwent CKRT in pediatric and neonatal intensive care units were analyzed. CKRT were initiated in patients with persistently high blood ammonia levels ([greater than or equal to] 500 [mu]mol/L), blood ammonia levels > 250 [mu]mol/L in the presence of moderate encephalopathy, high blood leucine levels ([greater than or equal to] 1500 [mu]mol/L), and blood leucine levels < 1500 [mu]mol/L in the presence of deteriorating neurological status or persistent metabolic acidosis. Results Of 22 patients enrolled, nine (40.9%) Maple syrup urine disease (MSUD), eight (36.4%) urea cycle disorders (UCD), and five (22.7%) organic acidemias (OA). Median age was 72.3 [9.9-1040.8] days. In total, 28 dialysis sessions were analyzed [16 (57.1%) continuous venovenous hemodialysis, and 12 (42.9%) continuous venovenous hemodiafiltration]. A significant decrease was noted in leucine levels (from 1608.4 ± 885.3 to 314.6 ± 109.9 [micro]mol/L) of patients with MSUD, while ammonia levels were significantly decreased in patients with UCD and OA (from 1279.9 ± 612.1 to 85.1 ± 21.6 [micro]mol/L). The most frequent complications of CKRT were thrombocytopenia (60.7%), hypotension (53.6%), and hypocalcemia (42.9%). Median age of patients with hypotension treated with vasoactive medications was significantly lower than median age of those with normal blood pressure. Conclusion CKRT is a reliable approach for effective and rapid removal of toxic metabolites in children with IEM, and CKRT modalities can be safely used and are well-tolerated in infants., Author(s): Fatma Tuba Eminoglu [sup.1] , Ümmühan Öncül [sup.1] , Fevzi Kahveci [sup.2] , Emel Okulu [sup.3] , Elvis Kraja [sup.3] , Engin Köse [sup.1] , Tanil Kendirli [sup.2] Author [...]

Published
2022
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12. Effect of Antenatal Magnesium Sulfate Exposure on Patent Ductus Arteriosus in Premature Infants

Author

Okulu, Emel, additional, Kraja, Elvis, additional, Kostekci, Yasemin Ezgi, additional, Seker, Erdal, additional, Ozisik, Mehmet Seckin, additional, Sarısoy, Doğacan, additional, Aslan, Batuhan, additional, Çakır, Maide Selin, additional, Demirtaş, Ferhan, additional, Ramoğlu, Mehmet Gökhan, additional, Uçar, Tayfun, additional, Erdeve, Omer, additional, Atasay, Begum, additional, Koc, Acar, additional, and Arsan, Saadet, additional

Published
2024
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13. Diagnostic challenge in a preterm infant with multiorgan failure: SARS-CoV-2 infection or neonatal multisystem inflammatory syndrome?

Author

Köstekci, Yasemin Ezgi, primary, Aydın, Alperen, additional, Arga, Gül, additional, Ramoğlu, Mehmet Gökhan, additional, Okulu, Emel, additional, Özdemir, Halil, additional, Uçar, Tayfun, additional, Karahan, Zeynep Ceren, additional, Erdeve, Ömer, additional, Atasay, Begüm, additional, and Arsan, Saadet, additional

Published
2024
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15. PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age

Author

Clyman, Ronald I, Liebowitz, Melissa, Kaempf, Joseph, Erdeve, Omer, Bulbul, Ali, Håkansson, Stellan, Lindqvist, Johanna, Farooqi, Aijaz, Katheria, Anup, Sauberan, Jason, Singh, Jaideep, Nelson, Kelly, Wickremasinghe, Andrea, Dong, Lawrence, Hassinger, Denise C, Aucott, Susan W, Hayashi, Madoka, Heuchan, Anne Marie, Carey, William A, Derrick, Matthew, Fernandez, Erika, Sankar, Meera, Leone, Tina, Perez, Jorge, Serize, Arturo, Investigators, PDA-TOLERATE Trial, Fields, Scott, Nurses, NCRC, Whitten, Lora, Rogers, Stefanie, Okulu, Emel, Tunc, Gaffari, Ucar, Tayfun, Ünal, Ebru Türkoglu, Steen, Jane, Arnell, Kathy, Holtschlag, Sarah, Schreiber, Michael, Peters, Caryn, Gilmore, Maureen, McKay, Lorna, Carole, Dianne, Shaw, Annette, Harris, Malinda, Amsbaugh, Amy, Liedl, Lavonne M, Wolf, Sue, Groner, Avi, Kimball, Amy, Kim, Jae, Bridge, Renee, Knodel, Ellen, Weng, Chrissy, Barbosa, Magaly Diaz, Polin, Richard, Weindler, Marilyn, Noori, Shahab, Reese, Jeffrey, Sun, Yao, Hospital, Umea University, and Santa Clara Medical Center, Kaiser Permanente

Subjects
Paediatrics, Biomedical and Clinical Sciences, Preterm, Low Birth Weight and Health of the Newborn, Lung, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Trials and Supportive Activities, Pediatric, Clinical Research, Hematology, Digestive Diseases, Infant Mortality, Reproductive health and childbirth, Good Health and Well Being, Acetaminophen, Conservative Treatment, Continuous Positive Airway Pressure, Cyclooxygenase Inhibitors, Ductus Arteriosus, Patent, Female, Gestational Age, Humans, Ibuprofen, Indomethacin, Infant, Extremely Premature, Infant, Newborn, Male, Prospective Studies, Single-Blind Method, Treatment Outcome, PDA-TOLERATE (PDA: TO LEave it alone or Respond And Treat Early) Trial Investigators, bronchopulmonary dysplasia, necrotizing enterocolitis, newborn, premature birth, retinopathy of prematurity, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo compare early routine pharmacologic treatment of moderate-to-large patent ductus arteriosus (PDA) at the end of week 1 with a conservative approach that requires prespecified respiratory and hemodynamic criteria before treatment can be given.Study designA total of 202 neonates of

Published
2019

16. Where Should the Transition of Newborns Who are Technology Dependent and in Need of Support to Home Care in Turkey?

Author

Demirtaş, Ferhan, Havan, Merve, Köstekci, Yasemin Ezgi, Özen, Hasan, Gurbanov, Anar, Kahveci, Fevzi, Okulu, Emel, Erdeve, Ömer, Atasay, Begüm, Kendirli, Tanıl, and Arsan, Saadet

Subjects
HOME care services, METABOLIC disorders, MORTALITY, TRACHEOTOMY, PALLIATIVE treatment, DATA analysis, HUMAN abnormalities, STATISTICAL significance, CHRONIC diseases in children, NEONATAL intensive care units, RESPIRATORY insufficiency, NEONATAL intensive care, CONTINUUM of care, DESCRIPTIVE statistics, DISCHARGE planning, TERTIARY care, RETROSPECTIVE studies, CHI-squared test, MANN Whitney U Test, TRANSITIONAL care, PEDIATRICS, HOSPITAL care of newborn infants, NEUROLOGICAL disorders, BURDEN of care, SEPTIC shock, INTENSIVE care units, ARTIFICIAL respiration, GASTROSTOMY, FAMILY-centered care, MEDICAL needs assessment, LENGTH of stay in hospitals, COMPARATIVE studies, DATA analysis software, CARDIAC arrest, CHILDREN
Abstract

Copyright of Journal of Pediatric Emergency & Intensive Care Medicine / Çocuk Acil ve Voğun Bakım Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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17. Incidence and risk factors for catheter-associated urinary tract infection in 623 intensive care units throughout 37 Asian, African, Eastern European, Latin American, and Middle Eastern nations: A multinational prospective research of INICC

Author

Rosenthal, Victor Daniel, primary, Yin, Ruijie, additional, Brown, Eric Christopher, additional, Lee, Brandon Hochahn, additional, Rodrigues, Camilla, additional, Myatra, Sheila Nainan, additional, Kharbanda, Mohit, additional, Rajhans, Prasad, additional, Mehta, Yatin, additional, Todi, Subhash Kumar, additional, Basu, Sushmita, additional, Sahu, Suneeta, additional, Mishra, Shakti Bedanta, additional, Chawla, Rajesh, additional, Nair, Pravin K., additional, Arjun, Rajalakshmi, additional, Singla, Deepak, additional, Sandhu, Kavita, additional, Palaniswamy, Vijayanand, additional, Bhakta, Arpita, additional, Nor, Mohd-Basri Mat, additional, Chian-Wern, Tai, additional, Bat-Erdene, Ider, additional, Acharya, Subhash P., additional, Ikram, Aamer, additional, Tumu, Nellie, additional, Tao, Lili, additional, Alvarez, Gustavo Andres, additional, Valderrama-Beltran, Sandra Liliana, additional, Jiménez-Alvarez, Luisa Fernanda, additional, Henao-Rodas, Claudia Milena, additional, Gomez, Katherine, additional, Aguilar-Moreno, Lina Alejandra, additional, Cano-Medina, Yuliana Andrea, additional, Zuniga-Chavarria, Maria Adelia, additional, Aguirre-Avalos, Guadalupe, additional, Sassoe-Gonzalez, Alejandro, additional, Aleman-Bocanegra, Mary Cruz, additional, Hernandez-Chena, Blanca Estela, additional, Villegas-Mota, Maria Isabel, additional, Aguilar-de-Moros, Daisy, additional, Castañeda-Sabogal, Alex, additional, Medeiros, Eduardo Alexandrino, additional, Dueñas, Lourdes, additional, Carreazo, Nilton Yhuri, additional, Salgado, Estuardo, additional, Abdulaziz-Alkhawaja, Safaa, additional, Agha, Hala Mounir, additional, El-Kholy, Amani Ali, additional, Daboor, Mohammad Abdellatif, additional, Guclu, Ertugrul, additional, Dursun, Oguz, additional, Koksal, Iftihar, additional, Havan, Merve, additional, Ozturk-Deniz, Suna Secil, additional, Yildizdas, Dincer, additional, Okulu, Emel, additional, Omar, Abeer Aly, additional, Memish, Ziad A., additional, Janc, Jarosław, additional, Hlinkova, Sona, additional, Duszynska, Wieslawa, additional, Horhat-Florin, George, additional, Raka, Lul, additional, Petrov, Michael M., additional, and Jin, Zhilin, additional

Published
2024
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18. An observational, multicenter, registry-based cohort study of Turkish Neonatal Society in neonates with Hypoxic ischemic encephalopathy

Author

Okulu, Emel, primary, Hirfanoglu, Ibrahim Murat, additional, Satar, Mehmet, additional, Erdeve, Omer, additional, Koc, Esin, additional, Ozlu, Ferda, additional, Gokce, Mahmut, additional, Armangil, Didem, additional, Tunc, Gaffari, additional, Demirel, Nihal, additional, Unal, Sezin, additional, Ozdemir, Ramazan, additional, Deveci, Mehmet Fatih, additional, Akar, Melek, additional, Demirel, Melike Kefeli, additional, Çetinkaya, Merih, additional, Buker, Halime Sema Can, additional, Karagöl, Belma Saygılı, additional, Yaprak, Deniz, additional, Akcan, Abdullah Barıs, additional, Anik, Ayse, additional, Narter, Fatma, additional, Arayici, Sema, additional, Yildirim, Egemen, additional, Akin, Ilke Mungan, additional, Sahin, Ozlem, additional, Ozdemir, Ozgul Emel Bulut, additional, Ovali, Fahri, additional, Akin, Mustafa Ali, additional, Celik, Yalcin, additional, Orman, Aysen, additional, Uslu, Sinan, additional, Ozkan, Hilal, additional, Koksal, Nilgun, additional, Tastekin, Ayhan, additional, Gunduz, Mehmet, additional, Arisoy, Ayse Engin, additional, Gurpinar, Resat, additional, Ors, Rahmi, additional, Altunhan, Huseyin, additional, Kececi, Ramazan, additional, Yildizdas, Hacer Yapicioglu, additional, Terek, Demet, additional, Ates, Mehmet, additional, Kader, Sebnem, additional, Mutlu, Mehmet, additional, Çelik, Kıymet, additional, Yucesoy, Ebru, additional, Mert, Mustafa Kurthan, additional, Gulasi, Selvi, additional, Kucuktasci, Kazım, additional, Arman, Didem, additional, Hekimoglu, Berna, additional, Gultekin, Nazlı Dilay, additional, Celik, Hasan Tolga, additional, Kahvecioglu, Dilek, additional, Akyildiz, Can, additional, Taşkın, Erdal, additional, Ciftdemir, Nukhet Aladag, additional, Uygun, Saime Sundus, additional, Kaya, Tugba Barsan, additional, Akdag, Arzu, additional, and Yilmaz, Aslan, additional

Published
2023
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24. PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age

Author

Fields, Scott, Whitten, Lora, Rogers, Stefanie, Okulu, Emel, Tunc, Gaffari, Ucar, Tayfun, Ünal, Ebru Türkoglu, Steen, Jane, Arnell, Kathy, Holtschlag, Sarah, Schreiber, Michael, Peters, Caryn, Gilmore, Maureen, McKay, Lorna, Carole, Dianne, Shaw, Annette, Harris, Malinda, Amsbaugh, Amy, Liedl, Lavonne M., Wolf, Sue, Groner, Avi, Kimball, Amy, Kim, Jae, Bridge, Renee, Knodel, Ellen, Weng, Chrissy, Barbosa, Magaly Diaz, Polin, Richard, Weindler, Marilyn, Noori, Shahab, Reese, Jeffrey, Sun, Yao, Clyman, Ronald I., Liebowitz, Melissa, Kaempf, Joseph, Erdeve, Omer, Bulbul, Ali, Håkansson, Stellan, Lindqvist, Johanna, Farooqi, Aijaz, Katheria, Anup, Sauberan, Jason, Singh, Jaideep, Nelson, Kelly, Wickremasinghe, Andrea, Dong, Lawrence, Hassinger, Denise C., Aucott, Susan W., Hayashi, Madoka, Heuchan, Anne Marie, Carey, William A., Derrick, Matthew, Fernandez, Erika, Sankar, Meera, Leone, Tina, Perez, Jorge, and Serize, Arturo

Published
2019
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27. Neonatal Resuscitation Practices in Turkey: A Survey of the Turkish Neonatal Society and the Union of European Neonatal and Perinatal Societies

Author

Engür, Defne, Cebeci, Burcu, Bayraktar, Bilge Tanyeri, Aygün, Canan, Aydemir, Özge, Aktaş, Selma, Akdağ, Arzu, Erdeve, Ömer, Koç, Esin, Okulu, Emel, Tüzün, Funda, Bağdiken, Ebru Yücesoy, Yılmaz, Fatma Hilal, Yılmaz, Aslan, Yıldırım, Şükran, Yasa, Beril, Yaman, Akan, Ünkar, Zeynep Alp, Ünal, Sezin, Uslu, Sinan, Türkmen, Münevver, Tunç, Gaffari, Tekgündüz, Kadir Şerafettin, Tayman, Cüneyt, Taşkın, Erdal, Tanrıverdi, Sema, Takcı, Sahın, Satar, Mehmet, Sarıcı, Dilek, Özüdoğru, Ebru, Yavuzcan Ozturk, Dilek, Özkan, Sariye Elif Özyazıcı, Özer, Esra Arun, Ovalı, Fahri, Ongun, Hakan, Olukman, Özgür, Narter, Fatma, Melekoğlu, Nuriye Aslı, Köroğlu, Özge Altun, Kılıç, Ertuğrul, Karagöl, Belma Saygılı, Kanburoğlu, Mehmet Kenan, Kahvecioğlu, Dilek, Kader, Şebnem, İnce, Zeynep, Hırfanoglu, Ibrahım Murat, Güler, Pelin, Taviloglu Gucyetmez, Safak, Gültekin, Nazlı Dilay, Fettah, Nurdan Dinlen, Ertuğrul, Sabahattin, Çelik, Kıymet, and Çelik, Hasan Tolga

Abstract

Objective: Optimal care in the delivery room is important to decrease neonatal morbidity and mortality. We aimed to evaluate neonatal resuscitation practices in Turkish centers. Materials and Methods: A cross-sectional survey consisted of a 91-item questionnaire focused on delivery room practices in neonatal resuscitation and was sent to 50 Turkish centers. Hospitals with

Published
2023

28. Evaluation of thymopoiesis in healthy Turkish children aged 0-6 years

Author

Kavgacı, Akif, primary, Doğu, Figen, additional, Arıkan, Meltem, additional, İslamoğlu, Candan, additional, Okulu, Emel, additional, Topçu, Seda, additional, Çullas-İlarslan, Nisa Eda, additional, Haskoloğlu, Şule, additional, Bal, Sevgi Köstel, additional, Bayrakoğlu, Deniz, additional, and İkincioğulları, Kamile Aydan, additional

Published
2023
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31. Pediatric Invasive Aspergillosis: A Retrospective Review of 59 Cases

Author

ÖZEN, Seval, primary, ÖZDEMİR, Halil, additional, TAŞKIN, Esra ÇAKMAK, additional, ARGA, Gül, additional, KONCA, Hatice Kübra, additional, ÇAKMAKLI, Hasan Fatih, additional, HASKOLOĞLU, Şule, additional, OKULU, Emel, additional, DİNÇASLAN, Handan, additional, İNCE, Elif, additional, İLERİ, Talia, additional, TAÇYILDIZ, Nurdan, additional, DOĞU, Figen, additional, EVREN, Ebru, additional, US, Ebru, additional, KARAHAN, Zeynep Ceren, additional, FİTÖZ, Suat, additional, KENDİRLİ, Tanıl, additional, KULOĞLU, Zarife, additional, TUTAR, Ercan, additional, İKİNCİOĞULLARI, Aydan, additional, ÜNAL, Emel, additional, ERTEM, Mehmet, additional, İNCE, Erdal, additional, and ÇİFTÇİ, Ergin, additional

Published
2022
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32. Neonatal Resuscitation Practices in Turkey: A Survey of the Turkish Neonatal Society and the Union of European Neonatal and Perinatal Societies.

Author

Okulu, Emel, Koç, Esin, Erdeve, Ömer, Akdağ, Arzu, Aktaş, Selma, Aydemir, Özge, Aygün, Canan, Bayraktar, Bilge Tanyeri, Cebeci, Burcu, Çelik, Hasan Tolga, Çelik, Kıymet, Engür, Defne, Ertuğrul, Sabahattin, Fettah, Nurdan Dinlen, Gültekin, Nazlı Dilay, Taviloğlu Güçyetmez, Zatigül Şafak, Gülen, Pelin, Hirfanoğlu, İbrahim Murat, İnce, Zeynep, and Kader, Şebnem

Subjects
*THERAPEUTIC use of nitric oxide, *PROFESSIONAL practice, *INDUCED hypothermia, *NEONATAL intensive care, *SPECIALTY hospitals, *NASAL cannula, *CROSS-sectional method, *CONTINUOUS positive airway pressure, *POSITIVE end-expiratory pressure, *HOSPITAL birthing centers, *FISHER exact test, *ARTIFICIAL respiration, *PEARSON correlation (Statistics), *QUESTIONNAIRES, *CHI-squared test, *DESCRIPTIVE statistics, *INFANT mortality, *RESUSCITATION, *PRENATAL care, *DATA analysis software
Abstract

Objective: Optimal care in the delivery room is important to decrease neonatal morbidity and mortality. We aimed to evaluate neonatal resuscitation practices in Turkish centers. Materials and Methods: A cross-sectional survey consisted of a 91-item questionnaire focused on delivery room practices in neonatal resuscitation and was sent to 50 Turkish centers. Hospitals with <2500 and those with ≥2500 births/year were compared. Results: In 2018, approximately 240 000 births occurred at participating hospitals with a median of 2630 births/year. Participating hospitals were able to provide nasal continuous-positive airway-pressure/high-flow nasal cannula, mechanical ventilation, high-frequency oscillatory ventilation, inhaled nitric oxide, and therapeutic hypothermia similarly. Antenatal counseling was routinely performed on parents at 56% of all centers. A resuscitation team was present at 72% of deliveries. Umbilical cord management for both term and preterm infants was similar between centers. The rate of delayed cord clamping was approximately 60% in term and late preterm infants. Thermal management for preterm infants (<32 weeks) was similar. Hospitals had appropriate equipment with similar rates of interventions and management, except continuous-positive-airway-pressure and positive-end-expiratory-pressure levels (cmH2O) used in preterm infants (P = .021, and P = .032). Ethical and educational aspects were also similar. Conclusions: This survey provided information on neonatal resuscitation practices in a sample of hospitals from all regions of Turkey and allowed us to see weaknesses in some fields. Although adherence to the guidelines was high among centers, further implementations are required in the areas of antenatal counseling, cord management, and circulation assessment in the delivery room. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Effects of Umbilical Cord Management Strategies on Stem Cell Transfusion, Delivery Room Adaptation, and Cerebral Oxygenation in Term and Late Preterm Infants

Author

Okulu, Emel, primary, Haskologlu, Sule, additional, Guloglu, Deniz, additional, Kostekci, Ezgi, additional, Erdeve, Omer, additional, Atasay, Begum, additional, Koc, Acar, additional, Soylemez, Feride, additional, Dogu, Figen, additional, Ikinciogullari, Aydan, additional, and Arsan, Saadet, additional

Published
2022
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38. Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society

Author

Akin I.M., Kanburoglu M.K., Tayman C., Oncel M.Y., Imdadoglu T., Dilek M., Yaman A., Narter, Fatma, Er, Ilkay, Kahveci, Hasan, Erdeve, Omer, Koc, Esin, Yildiz, Eren, Melekoglu, Nuriye Aslı, Okulu, Emel, Toptan, Handan Hakyemez, Surmeli, Ozge, Can, Emrah, Yilmaz, Fatma Hilal, Ozkan, Hilal, Caner, Ibrahim, Cömert, Serdar, Uygun, Saime Sundus, Akbay, Sinem, Memisoglu, Asli, Anik, Ayse, Arcagok, Baran Cengiz, Karagol, Belma Saygili, Ates, Mehmet, Bulut, Muhammet, Akin, Mustafa Ali, Demir, Nihat, Ozdemir, Ramazan, Arayici, Sema, Kader, Sebnem, Zubarioglu, Adil Umut, Oktem, Ahmet, Bulbul, Ali, Hekimoglu, Berna, Ataoglu, Emel, Baser, Demet Orhan, Yalinbas, Emine Esin, Imamoglu, Ebru Yalin, Ozlu, Ferda, Bilgin, Leyla, Kefeli, Melike, Arslan, Meltem Koyuncu, Akar, Selahattin, Bezirganoglu, Handan, Bozdag, Senol, Gurpinar, Resat, Ciftdemir, Nukhet Aladag, Ozdemir, Ozmert Ma, and Acibadem University Dspace

Subjects
multiple organ failure, vancomycin, epidemiological data, diarrhea, oxygen therapy, rash, assisted ventilation, computer assisted tomography, somnolence, partial thromboplastin time, Pregnancy, Severe acute respiratory syndrome coronavirus 2, Prospective Studies, Pregnancy Complications, Infectious, azithromycin, fever, Tachypnea, C reactive protein, disseminated intravascular clotting, artificial ventilation, carbapenem derivative, cohort analysis, Management, Myocarditis, female, rhinorrhea, breast feeding, mother to child transmission, real time polymerase chain reaction, Original Article, artificial milk, epidemiology, hospitalization, prospective study, lung consolidation, oseltamivir, COVID-19 testing, gentamicin, Article, coronavirus disease 2019, male, ground glass opacity, follow up, Humans, controlled study, irritability, human, coughing, protein expression, SARS-CoV-2, cephalosporin derivative, Infant, Newborn, birth weight, Infant, COVID-19, Newborn, major clinical study, neonatal intensive care unit, prothrombin time, Infectious Disease Transmission, Vertical, clinical feature, Postnatal, Cough, Pediatrics, Perinatology and Child Health, ampicillin, vertical transmission, pregnancy complication, newborn infection, continuous positive airway pressure
Abstract

The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5–28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [OR]: 9.52, 95% confidence interval [CI]: 4.17–21.71), tachypnea (OR: 26.5, 95% CI: 9.59–73.19), and chest retractions (OR: 27.5, 95% CI: 5.96–126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64% and specificity of 73%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course. Trial registration: ClinicalTrials.gov identifier: NCT04401540.What is Known:• Neonatal cases of COVID-19 infection are mainly reported as perinatal COVID-19 cases.• Neonates with perinatal transmission have a mild course and favorable prognosis.What is New:• Among symptomatic neonates with late-onset COVID-19 infection, fever was the most common symptom, and almost one quarter of hospitalized cases needed some type of respiratory support. Myocarditis was the most common complication.• The presence of cough, tachypnea, retractions, and a PT above 14 s were associated with an increased risk of severe COVID-19. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Published
2022

40. Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study

Author

Seymen-Karabulut, Gülcan, primary, Günlemez, Ayla, additional, Gökalp, Ayşe Sevim, additional, Hatun, Şükrü, additional, Kaya Narter, Fatma, additional, Mutlu, Mehmet, additional, Kader, Şebnem, additional, Terek, Demet, additional, Hanta, Deniz, additional, Okulu, Emel, additional, Karadeniz, Leyla, additional, Kanmaz Kutman, H. Gözde, additional, Zenciroğlu, Ayşegül, additional, Özdemir, Özmert M. A., additional, Sarıcı, Dilek, additional, Çelik, Muhittin, additional, Demir, Nihat, additional, Turan, Özden, additional, Çelik, Kıymet, additional, Kılıçbay, Fatih, additional, Uslu, Sinan, additional, Erol, Sara, additional, Ertuğrul, Sabahattin, additional, Er, Ilkay, additional, Çelik, Hasan Tolga, additional, Çetinkaya, Merih, additional, Aktürk-Acar, Filiz, additional, Aslan, Yakup, additional, Tunç, Gaffari, additional, Güran, Ömer, additional, and Engin Arısoy, Ayşe, additional

Published
2021
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41. The role of galactomannan test results in the diagnosis of pediatric invasive aspergillosis

Author

Özen, Seval, primary, Özdemir, Halil, additional, Evren, Ebru, additional, Taşkın, Esra Çakmak, additional, Arga, Gül, additional, Konca, Hatice Kübra, additional, Çakmaklı, Hasan Fatih, additional, Haskoloğlu, Şule, additional, Okulu, Emel, additional, Dinçaslan, Handan, additional, İnce, Elif, additional, İleri, Talia, additional, Taçyıldız, Nurdan, additional, Doğu, Figen, additional, Us, Ebru, additional, Karahan, Zeynep Ceren, additional, Fitöz, Suat, additional, Kendirli, Tanıl, additional, Kuloğlu, Zarife, additional, Tutar, Ercan, additional, İkincioğulları, Aydan, additional, Ünal, Emel, additional, Ertem, Mehmet, additional, İnce, Erdal, additional, and Çiftçi, Ergin, additional

Published
2021
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45. The impact of treatment options on neurodevelopmental status of neonates with jaundice requiring exchange transfusion

Author

Benderlioğlu, Elif, Atasay, Begüm, Okulu, Emel, Akın, Ezgi Özalp, Tunc, Gaffari, Köse, Elif, Pekcici, Emine Bahar Bingoler, Erdeve, Ömer, Ertem, İlgi, and Arsan, Saadet

Subjects
Kan değişimi, Neurodevelopment, Yenidoğan, Risk factors in jaundice, Exchange blood, Newborn, Sarılıkta risk faktörleri, Nörogelişim
Abstract

Giriş: Yenidoğan sarılığında kan değişimi, yaşamsal önemde ancak riskleri olan girişimsel bir işlemdir. Kan değişimi gerektirecek hiperbilirubinemi gelişiminin önlenmesi öncelikli yaklaşımdır. Çalışmamızda şiddetli hiperbilirubinemide, kan değişimi risk faktörleri ve ileri dönem nörogelişimsel durumun araştırılması amaçlanmıştır. Gereç ve Yöntem: Total serum bilirubin değeri Amerikan Pediatri Akademisi rehberine göre kan değişimi sınırında veya sınırın üstünde, 35 ve üstü gestasyonel hafta doğumlu 104 yenidoğan çalışmaya dahil edildi. Olguların 12-36 ayındayken ulaşılabilen 65’ine Gelişimi İzleme ve Destekleme Rehberi uygulandı. Kan değişimi uygulanan ve uygulanmayanlar sosyodemografik özellikler, risk faktörleri, etiyoloji, tedavi süreçleri ve ileri dönem nörogelişimsel durum açılarından karşılaştırıldı. Bulgular: Kan değişimi olguların %18,3’ünde uygulandı. Başvuru total serum bilirubin ve bilirubin/albümin oranı yüksekliği kan değişimi riskini arttıran temel değişkenlerdi. Kan değişimi riskini artıran eşik değerler, total serum bilirubinde 26,43 mg/dl ve bilirubin albümin oranında 7,43 mg/g saptandı. Sarılık etiyolojisinde ilk üç sırada; hemolitik hastalık, dehidratasyon ve erken anne sütü sarılığı ile prematürelik saptandı. Etiyolojilerle tedavi şekilleri arasında anlamlı ilişki bulunmadı. Postnatal 96 saatten sonra hastaneye başvuranların istatistiksel anlamlı yüsek bilirubinle (≥25 mg/dl) yattığı görüldü. On iki-otuz altı ayında değerlendirilen 65 olgunun %13,8’inde farklı alanlarda gelişimsel gecikme saptandı. Başvuru zamanı, tedavi şekilleri, total serum bilirubin ve bilirubin albümin oranıyla nörogelişimsel durum arasında anlamlı farklılık saptanmadı. Sonuç: Kan değişimi için başlıca risk faktörleri yüksek total serum bilirubin ve bilirubin albümin oranı bulundu. Hastaneye geç başvuranların daha sıklıkla ciddi hiperbilirubinemiyle yatması, taburculuk öncesi riskli grubun saptanması temel yaklaşımının önemini vurgulamaktadır. Ciddi hiperbilirubinemili olgular gelişimsel gecikmeler için riskli sayılmalı, düzenli izlem ve erken tanıyla müdahale fırsatları kaçırılmamalıdır. Introduction: Though predicting the emerging hyperbiluribinemia is the rational approach, timely exchange transfusion in significant neonatal hyperbilirubinemia is vital. The aim of this study is to evaluate the socio-demographic and clinical characteristics of newborns with significant hyperbilirubinemia, to evaluate risk factors for exchange transfusion and long-term neurodevelopmental status. Materials and Methods: Newborns who were admitted with bilirubin levels above the excahge transfusion thresholds (American Academy of Pediatrics, guideline 2004) total 104 cases were enrolled to the study. A total of 65 cases at 12-36 months were evaluated with Guide for Monitoring Child Development. The clinical and demographic characteristics, risk factors, treatment modalities, etiology of the groups and long-term neurodevelopmental status were compared between the groups with and without exchange transfusion, Results: Exchange transfusion was performed in 19 (18.3%) patients. Main factors that increase the risk of exchange transfusion were bilirubin level and bilirubin/albumin ratio. Cut-off bilirubin level and bilirubin/albumin ratio which increase the risk for exchage transfusion were 26.43mg/dl and 7.43mg/g respectively. The underlying etiologies were hemolytic disease (29.8%), dehydration and breast milk jaundice (28.8%), prematurity (26.9%). Late comers (postnatal >96 hours) were more likely to have bilirubin level ≥25 mg/dl. Development delays were detected in 13.8% of 65 cases. Conclusions: Admission bilirubin level and the ratio of bilirubin to albumin was among the factors that increase the risk of exchange transfusion. Late admission with significant hyperbiluribinemia may be prevented by identification of neonates at risk for developing significant hyperbilirubinemia before discharge or early in follow-up.

Published
2021

48. Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society.

Author

Akin, Ilke Mungan, Kanburoglu, Mehmet Kenan, Tayman, Cuneyt, Oncel, Mehmet Yekta, Imdadoglu, Timucin, Dilek, Mustafa, Yaman, Akan, Narter, Fatma, Er, Ilkay, Kahveci, Hasan, Erdeve, Omer, Koc, Esin, Neo-Covid Study Group, Yildiz, Eren, Melekoglu, Nuriye Aslı, Okulu, Emel, Toptan, Handan Hakyemez, Surmeli, Ozge, Can, Emrah, and Yilmaz, Fatma Hilal

Subjects
NEWBORN infants, CORONAVIRUS diseases, POSTNATAL care, DISEASE risk factors, PROTHROMBIN, THROMBOPLASTIN
Abstract

The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5–28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [OR]: 9.52, 95% confidence interval [CI]: 4.17–21.71), tachypnea (OR: 26.5, 95% CI: 9.59–73.19), and chest retractions (OR: 27.5, 95% CI: 5.96–126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64% and specificity of 73%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course. Trial registration: ClinicalTrials.gov identifier: NCT04401540. What is Known: • Neonatal cases of COVID-19 infection are mainly reported as perinatal COVID-19 cases. • Neonates with perinatal transmission have a mild course and favorable prognosis. What is New: • Among symptomatic neonates with late-onset COVID-19 infection, fever was the most common symptom, and almost one quarter of hospitalized cases needed some type of respiratory support. Myocarditis was the most common complication. • The presence of cough, tachypnea, retractions, and a PT above 14 s were associated with an increased risk of severe COVID-19. [ABSTRACT FROM AUTHOR]

Published
2022
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