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1,653 results on '"Okuno, K."'

2. Histograms in heavy-quark QCD at finite temperature and density

Author

Saito, H., Ejiri, S., Aoki, S., Kanaya, K., Nakagawa, Y., Ohno, H., Okuno, K., and Umeda, T.

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

We study the phase structure of lattice QCD with heavy quarks at finite temperature and density by a histogram method. We determine the location of the critical point at which the first-order deconfining transition in the heavy-quark limit turns into a crossover at intermediate quark masses through a change of the shape of the histogram under variation of coupling parameters. We estimate the effect of the complex phase factor which causes the sign problem at finite density, and show that, in heavy-quark QCD, the effect is small around the critical point. We determine the critical surface in 2+1 flavor QCD in the heavy-quark region at all values of the chemical potential mu including mu=infty., Comment: 26 pages, 21 figures, 1 table

Published
2013
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4. Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma

Author

Okuno K, Matsubara T, Nakamura T, Iino T, Kakimoto T, Asanuma K, Matsumine A, and Sudo A

Subjects
hypoxia, osteosarcoma, carbonic anhydrase IX, inhibitor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Kazuma Okuno,1,2 Takao Matsubara,1 Tomoki Nakamura,1 Takahiro Iino,1 Takuya Kakimoto,1 Kunihiro Asanuma,1 Akihiko Matsumine,1,3 Akihiro Sudo1 1Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan; 2Department of Orthopedic Surgery, Ise Red Cross Hospital, Ise, Japan; 3Department of Orthopedic Surgery, Fukui University Graduate School of Medicine, Fukui, Japan Purpose: We investigated the effect of carbonic anhydrase IX (CA IX) inhibitor under hypoxia and normoxia in SaOS2 human osteosarcoma cell line. We also evaluated the expression of CA IX in 27 patients diagnosed with osteosarcoma.Materials and methods: CA IX expression in SaOS2 cells cultured under different oxygen tensions was analyzed by Western blotting. To evaluate the effect of CA IX inhibitor, MTS cell viability assay was performed after cells were treated with various concentrations of doxorubicin with or without a CA IX inhibitor. Finally, CA IX expression in patient-derived osteosarcoma samples was evaluated by immunohistochemistry.Results: Treatment with CA IX inhibitor significantly suppressed cell proliferation and migration under hypoxic conditions. CA IX expression was observed in 81% of 27 patients. The 5-year survival rates in patients with high and low stain scores were 43.8% and 81.8%, respectively.Conclusion: CA IX inhibitors have the potential to suppress cell proliferation, migration, and chemoresistance. Keywords: hypoxia, osteosarcoma, carbonic anhydrase IX, inhibitor

Published
2018

8. Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study

Author

Mlecnik, B., Torigoe, T., Bindea, G., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Hirohashi, Y., Furuhata, T., Takemasa, I., Patel, P., Vora, H., Shah, B., Patel, J.B., Rajvik, K.N., Pandya, S.J., Shukla, S.N., Wang, Yili, Zhang, G., Yoshino, T., Taniguchi, H., Bifulco, C., Lugli, A., Lee, J.J., Zlobec, I., Rau, T.T., Berger, M.D., Nagtegaal, I.D., Vink-Borger, Elisa, Hartmann, A., Geppert, C.I., Kolwelter, J., Merkel, S., Grützmann, R., Eynde, M. Van den, Jouret-Mourin, A., Kartheuser, A., Léonard, D., Remue, C., Wang, J., Bavi, P., Roehrl, M.H.A., Ohashi, P.S., Nguyen, L.T., Han, S., MacGregor, H.L., Hafezi-Bakhtiari, S., Wouters, B.G., Masucci, G.V., Andersson, E., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M, Laghi, L., Grizzi, F., Marliot, F., Fredriksen, T., Buttard, B., Lafontaine, L., Maby, P., Majdi, A., Hijazi, A., Sissy, C. El, Kirilovsky, A., Berger, A., Lagorce, C., Paustian, C., Ballesteros-Merino, C., Dijkstra, J.R., Water, C. van de, Lent-van Vliet, S. van, Knijn, N., Mușină, A.M., Scripcariu, D.V., Marincola, F.M., Ascierto, P.A., Fox, B.A., Pagès, F., Kawakami, Y., Galon, J., Mlecnik, B., Torigoe, T., Bindea, G., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Hirohashi, Y., Furuhata, T., Takemasa, I., Patel, P., Vora, H., Shah, B., Patel, J.B., Rajvik, K.N., Pandya, S.J., Shukla, S.N., Wang, Yili, Zhang, G., Yoshino, T., Taniguchi, H., Bifulco, C., Lugli, A., Lee, J.J., Zlobec, I., Rau, T.T., Berger, M.D., Nagtegaal, I.D., Vink-Borger, Elisa, Hartmann, A., Geppert, C.I., Kolwelter, J., Merkel, S., Grützmann, R., Eynde, M. Van den, Jouret-Mourin, A., Kartheuser, A., Léonard, D., Remue, C., Wang, J., Bavi, P., Roehrl, M.H.A., Ohashi, P.S., Nguyen, L.T., Han, S., MacGregor, H.L., Hafezi-Bakhtiari, S., Wouters, B.G., Masucci, G.V., Andersson, E., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M, Laghi, L., Grizzi, F., Marliot, F., Fredriksen, T., Buttard, B., Lafontaine, L., Maby, P., Majdi, A., Hijazi, A., Sissy, C. El, Kirilovsky, A., Berger, A., Lagorce, C., Paustian, C., Ballesteros-Merino, C., Dijkstra, J.R., Water, C. van de, Lent-van Vliet, S. van, Knijn, N., Mușină, A.M., Scripcariu, D.V., Marincola, F.M., Ascierto, P.A., Fox, B.A., Pagès, F., Kawakami, Y., and Galon, J.

Abstract

Contains fulltext : 283495.pdf (Publisher’s version ) (Open Access), BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75-30.19); p = 0.0064). A High Immunoscore showed a significant association with prolonged TTR, OS, and DFS (p < 0.05). In Cox multivariable analysis stratified by center, Immunoscore association with TTR was independent (HR[Low-vs-Int+High] = 2.22 (95% CI 1.10-4.55) p = 0.0269) of the patient's gender, T-stage, N-stage, sidedness, and MSI status. A significant association of a High Immunoscore with prolonged TTR was also found among MSS (HR[Low-vs-Int+High] = 4.58 (95% CI 2.27-9.23); p ≤ 0.0001), stage II (HR[Low-vs-Int+High] = 2.72 (95% CI 1.35-5.51); p = 0.0052), low-risk stage-II (HR[Low-vs-Int+High] = 2.62 (95% CI 1.21-5.68); p = 0.0146), and high-risk stage II patients (HR[Low-vs-Int+High] = 3.11 (95% CI 1.39-6.91); p = 0.0055). CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.

Published
2022

18. Cryogenic System for ITER CS Model Coil

Author

Kato, T., Hamada, K., Kawano, K., Hiyama, T., Matsui, K., Nishida, K., Honda, T., Sekiguchi, S., Ootsu, K., Tsuji, H., Shimamoto, S., Okuno, K., Watanabe, Y., Tada, E., Nakayama, Y., Shimoda, M., and Kittel, Peter, editor

Published
1996
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22. The Second Test Results on the Nb3Sn Demo Poloidal Coil(DPC-EX)

Author

Ando, T., Nakajima, H., Sasaki, T-Y., Hiyama, T., Takahashi, Y., Nishi, M., Yoshida, K., Okuno, K., Kato, T., Sugimoto, M., Isono, T., Kawano, K., Koizumi, N., Hamada, K., Oshikiri, M., Sasaki, T., Wadayama, Y., Miyake, A., Iwamoto, S., Takahashi, T., Ebisu, H., Hosono, T., Yamamoto, K., Yasukawa, Y., Tsukamoto, H., Hanawa, H., Seki, S., Wakabayashi, H., Tsuji, H., Takayasu, M., Turck, B., Wuchuner, F., and Kittel, Peter, editor

Published
1994
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34. Microstructural observation of ITER [Nb.sub.3]Sn strands under bending strain

Author

Banno, N., Takeuchi, T., Koizumi, N., and Okuno, K.

Subjects
Bending -- Analysis, Niobium -- Magnetic properties, Niobium -- Electric properties, Niobium -- Mechanical properties, Nuclear reactors -- Design and construction, Superconducting magnets -- Mechanical properties, Technical institutes -- Management, Tin alloys -- Magnetic properties, Tin alloys -- Electric properties, Tin alloys -- Mechanical properties, Company business management, Business, Electronics, Electronics and electrical industries, International Thermonuclear Experimental Reactor -- Management
Published
2010

35. Superconducting property and strain effect study of the [Nb.sub.3]Sn strands developed for ITER

Author

Nunoya, Y., Hemmi, T., Nabara, Y., Matsui, K., Isono, T., Takahashi, Y., Koizumi, N., and Okuno, K.

Subjects
Niobium -- Magnetic properties, Niobium -- Electric properties, Nuclear reactors -- Design and construction, Technical institutes -- Management, Tin alloys -- Magnetic properties, Tin alloys -- Electric properties, Company business management, Business, Electronics, Electronics and electrical industries, International Thermonuclear Experimental Reactor -- Management
Published
2010

36. Development of the ITER toroidal field coil winding pack in Japan

Author

Koizumi, N., Nakajima, H., Matsui, K., Hemmi, T., Takano, K., Okuno, K., Hasegawa, M., Kakui, H., and Senda, I.

Subjects
Nuclear reactors -- Design and construction, Superconducting magnets -- Design and construction, Winding machines -- Design and construction, Welding research, Business, Electronics, Electronics and electrical industries
Published
2010

37. Status report on the toroidal field coils for the ITER project

Author

Savary, F., Bonito-Oliva, A., Gallix, R., Knaster, J., Koizumi, N., Mitchell, N., Nakajima, H., Okuno, K., and Sborchia, C.

Subjects
Electric coils -- Testing, Niobium -- Magnetic properties, Niobium -- Electric properties, Nuclear reactors -- Design and construction, Superconducting magnets -- Design and construction, Technical institutes -- Research, Tin alloys -- Magnetic properties, Tin alloys -- Electric properties, Business, Electronics, Electronics and electrical industries, International Thermonuclear Experimental Reactor -- Research
Published
2010

41. Characterization of [Nb.sub.3]Al strands subjected to an axial-strain for a fusion DEMO reactor

Author

Hemmi, T., Koizumi, N., Nunoya, Y., Okui, Y., Matsui, K., Nabara, Y., Isono, T., Takahashi, Y., Okuno, K., Banno, N., Kikuchi, A., Iijima, Y., and Takeuchi, T.

Subjects
Aluminum alloys -- Electric properties, Aluminum alloys -- Mechanical properties, Fusion reactors -- Design and construction, Niobium alloys -- Electric properties, Niobium alloys -- Mechanical properties, Tin alloys -- Electric properties, Tin alloys -- Mechanical properties, Business, Electronics, Electronics and electrical industries
Published
2009

42. Test results from the PF conductor insert coil and implications for the ITER PF system

Author

Bessette, D., Bottura, L., Devred, A., Mitchell, N., Okuno, K., Nunoya, Y., Sborchia, C., Takahashi, Y., Verweij, A., Vostner, A., Zanino, R., and Zapretilina, E.

Subjects
Electrical conduits -- Design and construction, Niobium alloys -- Thermal properties, Niobium alloys -- Magnetic properties, Nuclear reactors -- Design and construction, Titanium -- Magnetic properties, Titanium -- Thermal properties, Business, Electronics, Electronics and electrical industries
Published
2009

43. Installation and test programme of the ITER poloidal field conductor insert (PFCI) in the ITER test facility at JAEA Naka

Author

Nunoya, Y., Takahashi, Y., Hamada, K., Isono, T., Matsui, K., Oshikiri, M., Nabara, Y., Hemmi, T., Nakajima, H., Kawano, K., Tsutsumi, F., Takano, K., Uno, Y., Koizumi, N., Okuno, K., Baker, W., Salpietro, E., Rajainmaki, H., Sborchia, C., and Mitchell, N.

Subjects
Electrical conduits -- Design and construction, Electrical conduits -- Heating, cooling and ventilation, Niobium alloys -- Magnetic properties, Niobium alloys -- Electric properties, Nuclear reactors -- Design and construction, Nuclear reactors -- Testing, Titanium -- Magnetic properties, Titanium -- Electric properties, Business, Electronics, Electronics and electrical industries
Published
2009

44. Test results of the third Japanese SULTAN sample

Author

Matsui, K., Isono, T., Nunoya, Y., Hemmi, T., Okui, Y., Oshikiri, M., Koizumi, N., Takahashi, Y., Okuno, K., Stepanov, B., and Bruzzone, P.

Subjects
Niobium alloys -- Magnetic properties, Niobium alloys -- Electric properties, Nuclear reactors -- Design and construction, Superconductive devices -- Design and construction, Tin alloys -- Magnetic properties, Tin alloys -- Electric properties, Business, Electronics, Electronics and electrical industries
Published
2009

47. Investigation of a mechanism forming irregular loops in large CIC conductor

Author

Yagai, T., Nara, Y., Ohmura, J., Tsuda, M., Hamajima, T., Nunoya, Y., Okuno, K., and Takahata, K.

Subjects
Electric currents -- Evaluation, Superconductors -- Evaluation, Business, Electronics, Electronics and electrical industries
Abstract

The mechanism of the coupling loss is examined by measuring the trajectories of strands of sample CIC conductor. The studies have shown that probable loop lengths of long conductors are calculated by contact probabilities of two strands at each contactable point of two sub cables by newly developed function of twisting pitches.

Published
2008

48. Results of R&D on ITER-TF winding critical issues

Author

Koizumi, N., Nakajima, H., Matsui, K., Isono, T., Okuno, K., Takayanagi, T., Kuno, K., and Senda, I.

Subjects
Magnetic fields -- Analysis, Niobium -- Magnetic properties, Niobium -- Thermal properties, Nuclear reactors -- Design and construction, Tin alloys -- Magnetic properties, Tin alloys -- Thermal properties, Business, Electronics, Electronics and electrical industries
Abstract

The tests and analysis performed in Japan Atomic Energy Agency (JAEA) to solve the major technical issues in manufacturing the Toroidal Field coil winding pack (TFWP) are discussed. New impregnation method is under development for shortening the impregnation period.

Published
2008

49. Results of a new generation of ITER TF conductor samples in SULTAN

Author

Bruzzone, P., Stepanov, B., Wesche, R., Salpietro, E., Vostner, A., Okuno, K., Isono, T., Takahashi, Y., Hyoung Chan Kim, Keeman Kim, Shikov, A.K., and Sytnikov, V.E.

Subjects
Niobium -- Magnetic properties, Niobium -- Electric properties, Nuclear reactors -- Design and construction, Superconductors -- Analysis, Tin alloys -- Magnetic properties, Tin alloys -- Electric properties, Business, Electronics, Electronics and electrical industries
Abstract

The test results of the new generation of ITER TF conductor samples in SULTAN are discussed. The homogenization of performance toward the upper range has provided an effective margin for the operation of the ITER coil system.

Published
2008

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