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This paper explores the relationship between public spending and economic growth in Nigeria between 1981 and 2019. The study employs ARDL along with Granger causality test to determine the directional and dynamic relationship. The results show that social and community recurrent expenditure, social and community services capital expenditure and administration recurrent expenditure simulates Nigeria Economic growth (GDPGR), while, economic service recurrent expenditure (ESRX), economic service capital expenditure (ESCX), transfer capital expenditure and transfer recurrent expenditure deters Nigeria economic growth (GDPGR). The findings further reveal that there is unidirectional causality that runs from both administrative capital expenditure (ADCX) and administration recurrent expenditure (ADRX) to economic growth (GDPGR). The study recommends that government should increase her spending on both recurrent and capital expenditures on social and community as well as administrative recurrent expenditure to move towards achieving vision 2030, while it should reduce the budgetary allocation to capital and recurrent expenditure on transfer, administration capital expenditure, and also reduce borrowing to reduce debt services. Finally, the government should monitor the proper disbursement of the allocated fund, block all loopholes and ensure full implementation of the budget. [ABSTRACT FROM AUTHOR]

The primary aim of this research is to assess how sustainability corporate governance influences the disclosure of environmental practices by manufacturing companies listed in Nigeria. The research methodology employed in this investigation is ex-post facto, also referred to as a retrospective or causal-comparative design. The study's sample comprises ten selected listed manufacturing companies, chosen through purposive sampling techniques. Data for the study was gathered from sustainability reports and annual reports of these manufacturing firms listed on the Nigerian Stock Exchange (NSE). To investigate the relationships specified in the model, Ordinary Least Squares (OLS) regression analysis was applied. The coefficients for CSO (Chief Sustainability Officer) and EC (Environmental Committee) are 0.152 and 0.119, respectively. Their corresponding t-test values of 6.156 and 3.111 demonstrate statistical significance at the 5% level (p < 0.05). In contrast, the coefficient for SRC (Sustainability Reporting Committee) is 0.052, with a t-test value of 1.980, and a p-value exceeding 0.05 (p > 0.05). The research findings highlight significant connections between sustainability corporate governance practices and the disclosure of corporate environmental activities. Notably, Chief Sustainability Officers and Environmental Committees play influential roles in promoting more comprehensive and transparent environmental reporting practices among the listed manufacturing companies. Top of Form Key words: Sustainability Corporate Governance (SCG), Corporate Environmental Disclosure (CED), Environmental Committee, Corporate Governance, Sustainability, Environmental Performance, Environmental Impacts

The study examined the impact that sound financial management practices have on the overall performance of manufacturing companies in Nigeria. In this study, an ex-post-facto research strategy was used, and secondary data was collected so that the researchers could investigate the link between the variables. The population of the research was made up of five samples that were randomly chosen from the population as a whole. The information was taken from the company's annual financial report, which covered a period of ten (10) years (2010-2020). Ordinary Least Square (OLS) regression analysis was used in order to make sense of the gathered information. It was discovered that financial management practices have a positive significant effect on Profit after tax (PAT) (p0.0021); financial management practice has a positive significant effect on retained earnings (p0.0415); however, financial management practice has no significant effect on debt-to-equity (p>0.7350). These findings were derived from the findings of the research. The research concluded that there is a considerable positive association between effective financial management practice, profit after tax, and retained profits. This relationship is robust. According to the results, it was suggested that the management of manufacturing organizations should try to place a greater emphasis on the practice of financial management in order to improve the efficacy and efficiency of their operations.

Malaria still causes over 600,000 deaths annually, with rising resistance to frontline drugs by Plasmodium falciparum increasing this number each year. New medicines with novel mechanisms of action are, therefore, urgently needed. In this work, we solved the cocrystal structure of the essential malarial kinase Pf CLK3 with the reversible inhibitor TCMDC-135051 ( 1 ), enabling the design of covalent inhibitors targeting a unique cysteine residue (Cys368) poorly conserved in the human kinome. Chloroacetamide 4 shows nanomolar potency and covalent inhibition in both recombinant protein and P. falciparum assays. Efficacy in parasites persisted after a 6 h washout, indicating an extended duration of action. Additionally, 4 showed improved kinase selectivity and a high selectivity index against HepG2 cells, with a low propensity for resistance (log MIR > 8.1). To our knowledge, compound 4 is the first covalent inhibitor of a malarial kinase, offering promising potential as a lead for a single-dose malaria cure.