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192 results on '"Olano, Juan P."'

1. Hate speech detection in algerian dialect using deep learning

Author

Lanasri, Dihia, Olano, Juan, Klioui, Sifal, Lee, Sin Liang, and Sekkai, Lamia

Subjects
Computer Science - Computation and Language
Abstract

With the proliferation of hate speech on social networks under different formats, such as abusive language, cyberbullying, and violence, etc., people have experienced a significant increase in violence, putting them in uncomfortable situations and threats. Plenty of efforts have been dedicated in the last few years to overcome this phenomenon to detect hate speech in different structured languages like English, French, Arabic, and others. However, a reduced number of works deal with Arabic dialects like Tunisian, Egyptian, and Gulf, mainly the Algerian ones. To fill in the gap, we propose in this work a complete approach for detecting hate speech on online Algerian messages. Many deep learning architectures have been evaluated on the corpus we created from some Algerian social networks (Facebook, YouTube, and Twitter). This corpus contains more than 13.5K documents in Algerian dialect written in Arabic, labeled as hateful or non-hateful. Promising results are obtained, which show the efficiency of our approach.

Published
2023

5. A Bacteriophage-Based, Highly Efficacious, Needle- and Adjuvant-Free, Mucosal COVID-19 Vaccine

Author

Zhu, Jingen, primary, Jain, Swati, additional, Sha, Jian, additional, Batra, Himanshu, additional, Ananthaswamy, Neeti, additional, Kilgore, Paul B., additional, Hendrix, Emily K., additional, Hosakote, Yashoda M., additional, Wu, Xiaorong, additional, Olano, Juan P., additional, Kayode, Adeyemi, additional, Galindo, Cristi L., additional, Banga, Simran, additional, Drelich, Aleksandra, additional, Tat, Vivian, additional, Tseng, Chien-Te K., additional, Chopra, Ashok K., additional, and Rao, Venigalla B., additional

Published
2022
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7. Parasites

Author

Olano, Juan P., Cagle, Philip T., editor, Zander, Dani S., editor, Popper, Helmut H., editor, Jagirdar, Jaishree, editor, Haque, Abida K., editor, and Barrios, Roberto, editor

Published
2008
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11. Surface-expressed enolase contributes to the pathogenesis of clinical isolate SSU of Aeromonas hydrophila

Author

Sha, Jian, Erova, Tatiana E., Alyea, Rebecca A., Wang, Shaofei, Olano, Juan P., Pancholi, Vijay, and Chopra, Ashok K.

Subjects
Aeromonas -- Physiological aspects, Enolase -- Properties, Biological sciences
Abstract

In this study, we demonstrated that the surface-expressed enolase from diarrheal isolate SSU of Aeromonas hydrophila bound to human plasminogen and facilitated the latter's tissue-type plasminogen activator-mediated activation to plasmin. The bacterial surface-bound plasmin was more resistant to the action of its specific physiological inhibitor, the antiprotease [[alpha].sub.2] antiplasmin. We found that immunization of mice with purified recombinant enolase significantly protected the animals against a lethal challenge dose of wild-type (WT) A. hydrophila. Minimal histoiogical changes were noted in organs from mice immunized with enolase and then challenged with WT bacteria compared to severe pathological changes found in the infected and nonimmunized group of animals. This correlated with the smaller bacterial load of WT bacteria in the livers and spleens of enolase-immunized mice than that found in the nonimmunized controls. We also showed that the enolase gene could potentially be important for the viability of A. hydrophila SSU as we could delete the chromosomal copy of the enolase gene only when another copy of the targeted gene was supplied in trans. By site-directed mutagenesis, we altered five lysine residues located at positions 343, 394, 420, 427, and 430 of enolase in A. hydrophila SSU; the mutated forms of enolase were hyperexpressed in Escherichia coli, and the proteins were purified. Our results indicated that lysine residues at positions 420 and 427 of enolase were crucial in plasminogen-binding activity. We also identified a stretch of amino acid residues ([sub.252][FYDAEKKEY.sub.260]) in the A. hydrophila SSU enolase involved in plasminogen binding. To our knowledge, this is the first report of the direct involvement of surface-expressed enolase in the pathogenesis of A. hydrophila SSU infections and of any gram-negative bacteria in general.

Published
2009

13. Spotted fever rickettsiosis in Coronel Fabriciano, Minas Gerais State

Author

Galvão Márcio Antônio Moreira, Calic Simone Berger, Chamone Chequer Buffe, Mafra S. Cláudio Lísias, Cesarino Filho Gracco, Olano Juan Pablo, and Walker David Hughes

Subjects
Rickettsiosis, Brazilian spotted fever, Rickettsia rickettsii, Rickettsia typhi, Rickettsia felis, Arctic medicine. Tropical medicine, RC955-962
Abstract

We report cases of spotted fever rickettsiosis in Coronel Fabriciano Municipality of Minas Gerais State, Brazil. The cases occurred in May and June of 2000. During this period there were two deaths among children from an area named Pedreira in a periurban area of this municipality. In a boy who died with clinical manifestations of Brazilian spotted fever, a necropsy revealed the presence of a spotted fever group Rickettsia. The serological results confirm the difficulty in the differential diagnosis of patients with symptoms of rickettsial diseases.

Published
2003

14. Attitudes and Beliefs of Pathology Residents Regarding the Subspecialty of Clinical Chemistry: Results of a Survey

Author

Haidari, Mehran, Yared, Marwan, Olano, Juan P., Alexander, C. Bruce, and Powell, Suzanne Z.

Subjects
Residents (Medicine) -- Vocational guidance, Pathologists -- Vocational guidance, Clinical chemistry -- Appreciation, Health
Abstract

* Context.--Previous studies suggest that training in pathology residency programs does not adequately prepare pathology residents to become competent in clinical chemistry. Objectives.--To define the beliefs of pathology residents in the United States regarding their preparation for practicing clinical chemistry in their career, their attitude toward the discipline, and the attractiveness of clinical chemistry as a career. Design.--The residents of all pathology residency programs in the United States were given the opportunity to participate in an online survey. Results.--Three hundred thirty-six pathology residents responded to the survey. Analysis of the survey results indicates that pathology residents are more likely to believe that their income may be lower if they select a career that has a clinical chemistry focus and that their faculty do not value clinical chemistry as much as the anatomic pathology part of the residency. Residents also report that clinical chemistry is not as enjoyable as anatomic pathology rotations during residency or preferable as a sole career path. A large proportion of residents also believe that they will be slightly prepared or not prepared to practice clinical chemistry by the end of their residency and that they do not have enough background and/or time to learn clinical chemistry during their residency programs to be able to practice this specialty effectively post graduation. Conclusions.--Our survey results suggest that many pathology residents do not have a positive attitude toward clinical chemistry and do not experience a supportive learning environment with an expectation that they will become competent in clinical chemistry with a residency alone. (Arch Pathol Lab Med. 2017;141:203-208; doi: 10.5858/arpa.2015-0547-OA), All residency-training programs are obligated to transition graduates of medical schools into competent practitioners in a specialty area within a relatively brief period. A key question is whether graduates of [...]

Published
2017
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15. Colaboradores

Author

Abraham, Naif Z., Jr, Aoyagi, Katsumi, Ashihara, Yoshihiro, Asirvatham, Jaya Ruth, Axiotis, Constantine A., Bai, Yu, Balis, Ulysses G.J., Banki, Katalin, Bean, Katie V., Beavis, Kathleen G., Bem, Sylva, Ben-Ezra, Jonathan, Bigdeli, Tim B., Bluth, Martin H., Bobr, Aleh, Bock, Jay L., Borowitz, Michael J., Bowne, Wilbur B., Brandt-Rauf, Paul, Bray, Robert, Bredefeld, Cindy L., Briefel, Gary, Broadhurst, M. Jana, Carty, Robert P., Ceribelli, Angela, Chan, Edward K.L., Charnot-Katsikas, Angella, Cherian, Sindhu, Chiang, Spencer, Clapp, William L., Cooling, Laura Lee, Daniels, Lynsey, Davenport, Robertson D., DeCresce, Robert P., Delgado, Julio C., DeSimone, Robert A., DiGuardo, Margaret A., Paola, Jorge A. Di, Downs, Theresa, Elghetany, M. Tarek, Elkins, Matthew B., Fanous, Ayman, Fritzler, Marvin J., Gebel, Howard M., Goldstein, Eve, Graham, Susan S., Grody, Wayne W., Guber, Helena A., Gupta, Gaurav, Hamilton, Robert G., Harrington, Amanda, Harris, Neil Selwyn, He, Rong, Hilbert, Tim, Hirschhorn, Julie Woolworth, Hogan, Catherine A., Holup, Joseph, Homburger, Henry A., Hsu, Yen-Michael S., Hussain, M. Mahmood, Hutchison, Robert E., Iwen, Peter C., Jain, Shilpa, Jeelani, Roohi, Jennette, J. Charles, Jhang, Jeffrey S., Karcher, Donald S., Kasahara, Yasushi, Kaskovich, Samuel W., Kessler, Craig M., Khalili, Marian, Kidd, Jason, Klein, Michael J., Klemm, Katrin M., Krick, Stefanie, Krummey, Scott, Kumánovics, Attila, Kurec, Anthony, LaDoulis, Charles, Lau, Raymond G., Lázár-Molnár, Eszter, Lee, Grace Ming, Lee, Peng, Li, Jing, Lifshitz, Mark S., Lin, Bo, Mageau, Ronald P., Markell, Mariana, Massey, H. Davis, Mathison, Blaine A., Mathur, Sharad C., McPherson, Richard A., McVoy, Lauren A., Merkel, Kimberly, Meyers, Jacquelyn L., Miller, W. Greg, Mintz, Paul D., Mohi, Golam, Mojica, Angela, Nasr, Michel R., Nikolic, Dejan, Nolte, Frederick S., Oh, Man S., Olano, Juan P., Oprea, Mihaela, Ortel, Thomas L., Ouyang, Zheng, Perle, Mary Ann, Peterson, Roseann E., Pincus, Matthew R., Pinsky, Benjamin A., Plourde, Anna R., Pritt, Bobbi S., Rabinowitz, Simon, Raje, Nikita, Rand, Jacob H., Rao, A. Koneti, Riley, Roger S., Roby, Rhonda K., Rodino, Kyle G., Russell, Yan Xue, Sarode, Ravi, Schandl, Cynthia A., Seydhafkan, Shabnam, Siddiqi, Haseeb A., Songdej, Natthapol, Stein, Constance H., Stempak, Lisa M., Sullivan, H. Clifford, Thompson, George R., III, Vajpayee, Neerja, Viswanatha, David S., von Mühlen, Carlos Alberto, Walker, David H., Wang, Hannah, Weedn, Victor W., Weimer, Eric T., Weinstock, Ruth S., Wengenack, Nancy L., Wiederhold, Nathan P., Winter, William E., Winters, Jeffrey L., Wojewoda, Christina M., Wood, Brent L., Woods, Gail L., Zhang, Wenpeng, and Zhang, Yaxia

Published
2023
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16. Contributors

Author

Abdalla, Saad H., primary, Acrani, Gustavo Olszanski, additional, Aggarwal, Rakesh, additional, Allos, Ban Mishu, additional, Alter, Miriam J., additional, Andrus, Jon K., additional, Angel, Juana, additional, Anstead, Gregory M., additional, Arathoon, Eduardo, additional, Arruda, Eurico, additional, Arthur, Ray R., additional, Atmar, Robert L., additional, Banura, Patrick, additional, Barbour, Alan G., additional, Barrett, Alan D.T., additional, Bausch, Dan, additional, Berk, Steven L., additional, Bessong, Pascal O., additional, Bia, Frank J., additional, Bicanic, Tihana, additional, Black, Robert E., additional, Bleck, Thomas P., additional, Boggild, Andrea K., additional, Bonnez, William, additional, Bresee, Joseph S., additional, Brown, Corrie, additional, Brown, Lillian B., additional, Brunetti, Enrico, additional, Bruschi, Fabrizio, additional, Bryant, Amy E., additional, Campbell, Carlos C. (Kent), additional, Castillo-Solorzano, Carlos, additional, Cetron, Martin S., additional, Chen, Ding-Shinn, additional, Chen, Pei-Jer, additional, Chen, Xiang-Sheng, additional, Cherian, Thomas, additional, Chua, K.B., additional, Cohen, Myron S., additional, Cooke, Graham S., additional, Cooper, Chester R., additional, Cooper, Edward S., additional, Coyle, Christina M., additional, Cross†, John H., additional, Dance, David A.B., additional, Danesi, Mustapha A., additional, Dawson, Chandler R., additional, de Martel, Catherine, additional, De Quadros, Ciro A., additional, de Queiroz Sousa, Anastacio, additional, de Silva, Nilanthi R., additional, de Souza, Alexandre Leite, additional, Dehio, Christoph, additional, Diemert, David J., additional, Dillingham, Rebecca, additional, Donelson, John E., additional, Dumler, J. Stephen, additional, Duncan, Joseph A., additional, DuPont, Herbert L., additional, Durand, Marlene L., additional, Eberhard, Mark L., additional, Eby, Joshua C., additional, Edwards, Charles, additional, Eidex, Rachel B., additional, Ellner, Jerrold J., additional, Enría, Delia A., additional, Ergonul, Onder, additional, Estes, Mary K., additional, Fahal, Ahmed Hassan, additional, Farmer, Paul E., additional, Faruque, A.S.G., additional, Feldman, Charles, additional, Feldmann, Heinz, additional, Fox, Kimberley K., additional, Franceschi, Silvia, additional, Franco, Manuel A., additional, Fulhorst, Charles F., additional, Garcia, Hector H., additional, Genta, Robert M., additional, Gilman, Robert H., additional, Glass, Roger I., additional, Goddard, Jerome, additional, Gotuzzo, Eduardo, additional, Graybill, John R., additional, Greenberg, Harry B., additional, Griffiths, Paul D., additional, Gubler, Duane J., additional, Guerrant, Richard L., additional, Gutierrez, Yezid, additional, Hewlett, Erik L., additional, Heymann, David L., additional, Hill, David R., additional, Ho, Mei-Shang, additional, Hoerauf, Achim M., additional, Hoffman, Paul S., additional, Hoffman, Stephen L., additional, Holbrook, Michael R., additional, Holland, Thomas L., additional, Hopkins, Donald R., additional, Hospenthal, Duane R., additional, Hotez, Peter J., additional, Hudnall, S. David, additional, Hughes, James M., additional, Hwang, Kao-Pin, additional, Isturiz, Raul E., additional, Jahrling, Peter B., additional, Jameel, Shahid, additional, Jeronimo, Selma M.B., additional, Jones-Lopez, Edward C., additional, Kabanova, Anna, additional, Kang, Gagandeep, additional, Karp, Christopher L., additional, Kazura, James W., additional, Kern, Peter, additional, Keusch, Gerald T., additional, Keystone, Jay S., additional, Khuroo, Mehnaaz S., additional, Khuroo, Mohammad S., additional, Kim, Ik-Sang, additional, King, Charles H., additional, Kirchhoff, Louis V., additional, Klion, Amy D., additional, Klugman, Keith P., additional, Kopecko, Dennis J., additional, Kosek, Margaret, additional, Koster, Frederick T., additional, Kozarsky, Phyllis E., additional, Ksiazek, Thomas G., additional, Kuhn, Jens H., additional, Lastovica, Albert J., additional, LeDuc, James W., additional, Leone, Peter A., additional, Levett, Paul N., additional, Levin, Michael, additional, Levine, Myron M., additional, Lima, Aldo A.M., additional, Lindeque, Gerhard, additional, Longworth, David L., additional, Mabey, David, additional, Maclean†, J. Dick, additional, Magill, Alan J., additional, Maguilnik, Ismael, additional, Maguiña, Ciro, additional, Maguire, James H., additional, Mahanty, Siddhartha, additional, Makino, Shinji, additional, Mandl, Christian W., additional, Marrie, Thomas J., additional, Marshall, Barry J., additional, Martin, Gregory J., additional, Matsumoto, Tadahiko, additional, Mawhorter, Steven D., additional, McCarthy, James S., additional, McGinnis, Michael R., additional, Mead, Paul S., additional, Meyers, Wayne M., additional, Miller, Robert F., additional, Miller, Samuel I., additional, Mills, James N., additional, Monath, Thomas P., additional, Moore, Christopher C., additional, Moore, Thomas A., additional, Morrill, J.C., additional, Morris, J. Glenn, additional, Murray, Megan, additional, Murrell, K. Darwin, additional, Nair, G. Balakrish, additional, Nash, Theodore E., additional, Nathan, Barnett R., additional, Negroni, Ricardo, additional, Nicholson-Weller, Anne, additional, Nucci, Marcio, additional, Nutman, Thomas B., additional, O’Farrell, Nigel, additional, Olano, Juan P., additional, Ooi, Eng Eong, additional, Ortega, Luis S., additional, Ortega, Ynés R., additional, Pallansch, Mark A., additional, Pape, Jean W., additional, Pappas, Georgios, additional, Parsonnet, Julie, additional, Pasvol, Geoffrey, additional, Peacock, Sharon J., additional, Pearson, Richard D., additional, Peeling, Rosanna W., additional, Pegues, David A., additional, Pépin, Jacques, additional, Peters, C.J., additional, Peterson, Kristine M., additional, Petri, William A., additional, Portaels, Françoise, additional, Proença-Módena, José Luiz, additional, Quinn, Thomas C., additional, Rao, G. Raghurama, additional, Raoult, Didier, additional, Rappuoli, Rino, additional, Rex, John H., additional, Reynolds, Steven J., additional, Ribeiro, José M.C., additional, Roilides, Emmanuel, additional, Rollin, Pierre E., additional, Ronald, Allan R., additional, Rota, Paul A., additional, Roy, Sharon L., additional, Ruiz-Tiben, Ernesto, additional, Ryan, Edward T., additional, Saha, Debasish, additional, Salam, Mohammed A., additional, Samie, Amidou, additional, Schachter, Julius, additional, Schantz, Peter M., additional, Scheld, W. Michael, additional, Schlaudecker, Elizabeth P., additional, Schwartz, David A., additional, Schwartzman, Joseph D., additional, Seña, Arlene C., additional, Sexton, Daniel J., additional, Sharp, Truman W., additional, Shieh, Wun-Ju, additional, Shoham, Shmuel, additional, Siddiqui, Afzal A., additional, Singh, Upinder, additional, Smith, David W., additional, Smith, Michael B., additional, Smoak, Bonnie L., additional, Smulian, A. George, additional, Snider, Cynthia B., additional, Solomon, Tom, additional, Sow, Samba O., additional, Sparling, P. Frederick, additional, Spencer, Lisa A., additional, Stanberry, Lawrence R., additional, Staples, J. Erin, additional, Steffen, Robert, additional, Steiner, Theodore S., additional, Steinhoff, Mark C., additional, Stevens, Dennis L., additional, Suh, Kathryn N., additional, Supparatpinyo, Khuanchai, additional, Szaniszlo, Paul J., additional, Tapia, Milagritos D., additional, Tanowitz, Herbert B., additional, Telford, Sam R., additional, Tesh, Robert B., additional, Thielman, Nathan M., additional, Torres-Vélez, Fernando J., additional, Tucker, Joseph D., additional, Valdez, Luis M., additional, Valenzuela, Jesus G., additional, van de Beek, Diederik, additional, Vasconcelos, Pedro F.C., additional, Visvesvara, Govinda S., additional, Wahl-Jensen, Victoria, additional, Walker, David H., additional, Walsh, Douglas S., additional, Walsh, Thomas J., additional, Walton, David A., additional, Walzer, Peter D., additional, Warren, Cirle A., additional, Weaver, Scott C., additional, Weiss, Louis M., additional, Weller, Peter F., additional, White, A. Clinton, additional, White, Nicholas J., additional, Wilkinson, Robert J., additional, Wilson, Mary E., additional, Wittner, Murray, additional, Zaidi, Anita K.M., additional, and Zaki, Sherif R., additional

Published
2011
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19. Human monocytotropic ehrlichiosis, Missouri

Author

Olano, Juan P., Masters, Edwin, Hogrefe, Wayne, and Walker, David H.

Subjects
Ehrlichiosis -- Research
Abstract

To determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an [...]

Published
2003

25. List of Contributors

Author

Aoki, Valeria, primary, Aranda, Jennifer, additional, Assimwe, Francis T., additional, Azulay, Rubem David, additional, de Brito, Arival Cardoso, additional, Bacellar, Fatima, additional, Benson, Col Paul M., additional, Barnetson, Ross, additional, Bessinger, G. Todd, additional, Botelho, Michelle Gralle, additional, Bravo, Francisco G., additional, Brentjens, Mathijs, additional, Burdick, Anne E., additional, Burnett, Mark, additional, Cabrera, Juan, additional, Capó, Virginia A., additional, Campbell, Iphis, additional, de Cerquiera, Ana Maria Mosca, additional, Currie, Bart, additional, Demers, Denise M., additional, Diaz, Luis A., additional, Elston, Dirk M., additional, Ericsson, Charles D., additional, del Favero, Wânia Mara, additional, Filho, Gunter Hans, additional, Florião, Ryssia Alvarez, additional, Francescone, Fábio, additional, Frankel, Stacy, additional, Gotuzzo, Eduardo, additional, Junior, Vidal Haddad, additional, Hilario-Vargas, Julio, additional, Huang, David B., additional, Häussinger, Dieter, additional, Hengge, Ulrich R., additional, Jardim, Márcio Lobo, additional, Joffe, Renata A., additional, Kalungi, Sam, additional, Kamath, Ratnakar, additional, Ko, Christine, additional, Kouri, Gustavo, additional, Lee, Patricia, additional, Leutscher, Peter, additional, Lupi, Omar, additional, Machado-Pinto, Jackson, additional, Magnussen, Pascal, additional, Maia, Claudia Pires do Amaral, additional, Maniar, Janak, additional, Mahé, Antoine, additional, McGinnis, Michael R., additional, Meffert, Jeffrey, additional, Meixner, Jeffery A., additional, Meza-Valencia, Beatriz, additional, Moon, Charles, additional, Motta, Rogerio Neves, additional, Mwesigye, Frank, additional, Nascimento, Leninha Valério do, additional, Niemeyer-Corbellini, Joao Paulo, additional, Neves, René Garrido, additional, Nguyen, Josephine, additional, Olano, Juan P., additional, Ottolini, Martin, additional, Pang, Katie R., additional, Passos, Mauro Romero Leal, additional, Patel, Seema, additional, Perez, Dominique Fausto, additional, Reis, Andréa Neiva dos, additional, Rehmus, Wingfield, additional, Richter, Karl Heinz, additional, Richter, Joachim, additional, Rivitti, Evandro, additional, Sampaio, Sebastião A.P., additional, Santos, Omar da Rosa, additional, Semenovitch, Ivan, additional, Smith, Michael B., additional, Spinelli, Leticia, additional, de Sousa, Rita, additional, Sra, Karan K., additional, Talhari, Carolina, additional, Talhari, Sinésio, additional, Tumwine, Lynnette K., additional, Turner, Maria L., additional, Tyring, Stephen K., additional, Varella, Renata de Queiroz, additional, do Valle, Antônio Carlos Francescone, additional, Vera-Cabrera, Luciano, additional, Vivesvara, Govinda S., additional, Welsh, Olivera, additional, White, Anthony, additional, Wu, Jashin J., additional, Younes-Ibrahim, Mauricio, additional, and Zaitz, Clarisse, additional

Published
2006
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33. Contributors

Author

Abraham, Naif Z., Jr, Aoyagi, Katsumi, Ashihara, Yoshihiro, Asirvatham, Jaya Ruth, Axiotis, Constantine A., Bai, Yu, Balis, Ulysses G.J., Banki, Katalin, Bean, Katie V., Beavis, Kathleen G., Bem, Sylva, Ben-Ezra, Jonathan, Bigdeli, Tim B., Bluth, Martin H., Bobr, Aleh, Bock, Jay L., Borowitz, Michael J., Bowne, Wilbur B., Brandt-Rauf, Paul, Bray, Robert, Bredefeld, Cindy L., Briefel, Gary, Broadhurst, M. Jana, Carty, Robert P., Ceribelli, Angela, Chan, Edward K.L., Charnot-Katsikas, Angella, Cherian, Sindhu, Chiang, Spencer, Clapp, William L., Lee Cooling, Laura, Daniels, Lynsey, Davenport, Robertson D., DeCresce, Robert P., Delgado, Julio C., DeSimone, Robert A., DiGuardo, Margaret A., Di Paola, Jorge A., Downs, Theresa, Elghetany, M. Tarek, Elkins, Matthew B., Fanous, Ayman, Fritzler, Marvin J., Gebel, Howard M., Goldstein, Eve, Graham, Susan S., Grody, Wayne W., Guber, Helena A., Gupta, Gaurav, Hamilton, Robert G., Harrington, Amanda, Harris, Neil Selwyn, He, Rong, Hilbert, Tim, Hirschhorn, Julie Woolworth, Hogan, Catherine A., Holup, Joseph, Homburger, Henry A., Hsu, Yen-Michael S., Hussain, M. Mahmood, Hutchison, Robert E., Iwen, Peter C., Jain, Shilpa, Jeelani, Roohi, Jennette, J. Charles, Jhang, Jeffrey S., Karcher, Donald S., Kasahara, Yasushi, Kaskovich, Samuel W., Kessler, Craig M., Khalili, Marian, Kidd, Jason, Klein, Michael J., Klemm, Katrin M., Krick, Stefanie, Krummey, Scott, Kumánovics, Attila, Kurec, Anthony, LaDoulis, Charles, Lau, Raymond G., Lázár-Molnár, Eszter, Lee, Grace Ming, Lee, Peng, Li, Jing, Lifshitz, Mark S., Lin, Bo, Mageau, Ronald P., Markell, Mariana, Massey, H. Davis, Mathison, Blaine A., Mathur, Sharad C., McPherson, Richard A., McVoy, Lauren A., Merkel, Kimberly, Meyers, Jacquelyn L., Miller, W. Greg, Mintz, Paul D., Mohi, Golam, Mojica, Angela, Nasr, Michel R., Nikolic, Dejan, Nolte, Frederick S., Oh, Man S., Olano, Juan P., Oprea, Mihaela, Ortel, Thomas L., Ouyang, Zheng, Perle, Mary Ann, Peterson, Roseann E., Pincus, Matthew R., Pinsky, Benjamin A., Plourde, Anna R., Pritt, Bobbi S., Rabinowitz, Simon, Raje, Nikita, Rand, Jacob H., Rao, A. Koneti, Riley, Roger S., Roby, Rhonda K., Rodino, Kyle G., Russell, Yan Xue, Sarode, Ravi, Schandl, Cynthia A., Seydhafkan, Shabnam, Siddiqi, Haseeb A., Songdej, Natthapol, Stein, Constance H., Stempak, Lisa M., Sullivan, H. Clifford, Thompson, George R., III, Vajpayee, Neerja, Viswanatha, David S., Alberto von Mühlen, Carlos, Walker, David H., Wang, Hannah, Weedn, Victor W., Weimer, Eric T., Weinstock, Ruth S., Wengenack, Nancy L., Wiederhold, Nathan P., Winter, William E., Winters, Jeffrey L., Wojewoda, Christina M., Wood, Brent L., Woods, Gail L., Zhang, Wenpeng, and Zhang, Yaxia

Published
2022
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34. Lymphangitis in a Portuguese patient infected with Rickettsia sibirica

Author

de Sousa, Rita, Duque, Luis, Anes, Margarida, Pocas, Jose, Torgal, Jorge, Bacellar, Fatima, Olano, Juan P., and Walker, David H.

Abstract

To the Editor: We report a case of Rickettsia sibirica mongolitimoniae strain infection associated with lymphangitis (1). A 44-year-old man was admitted to Sao Bernardo Hospital in Setubal, Portugal, on [...]

Published
2008

35. Rocky Mountain spotted fever, Colombia

Author

Hidalgo, Marylin, Orejuela, Leonora, Fuya, Patricia, Carrillo, Pilar, Hernandez, Jorge, Parra, Edgar, Keng, Colette, Small, Melissa, Olano, Juan P., Bouyer, Donald, Castaneda, Elizabeth, Walker, David, and Valbuena, Gustavo

Subjects
Rickettsia -- Research, Rocky Mountain spotted fever -- Diagnosis, Rocky Mountain spotted fever -- Care and treatment, Rocky Mountain spotted fever -- Research, Colombia -- Health aspects
Abstract

We investigated 2 fatal cases of Rocky Mountain spotted fever that occurred in 2003 and 2004 near the same locality in Colombia where the disease was first reported in the [...]

Published
2007

37. Fatal human infection with Rickettsia rickettsii, Yucatan, Mexico

Author

Zavala-Castro, Jorge E., Zavala-Velazquez, Jorge E., Walker, David H., Arcila, Edgar E. Ruiz, Laviada-Molina, Hugo, Olano, Juan P., Ruiz-Sosa, Jose A., Small, Melissa A., and Dzul-Rosado, Karla R.

Subjects
Rickettsial diseases -- Diagnosis, Rickettsial diseases -- Research, Rickettsial diseases -- Causes of, Rickettsial diseases -- Care and treatment
Abstract

The first fatal Rickettsia rickettsii infection was diagnosed in the southwest of Mexico. The patient had fever, erythematous rash, abdominal pain, and severe central nervous system involvement with convulsive crisis. [...]

Published
2006

42. How Cytokines Co-occur across Rickettsioses Patients: From Bipartite Visual Analytics to Mechanistic Inferences of a Cytokine Storm

Author

Bhavnani, Suresh K., Drake, Justin, Bellala, Gowtham, Dang, Bryant, Peng, Bi-Hung, Oteo, Jose Antonio, Santibañez-Saenz, Paula, Visweswaran, Shyam, and Olano, Juan P.

Subjects
Articles
Abstract

Several intersecting host, vector, and environmental factors have led to a re-emergence of rickettsial diseases such as Mediterranean Spotted Fever (MSF), and Dermacentor spp.-borne necrosis-erythema lymphadenopathy (DEBONEL). Some rickettsiae produce diffuse endothelial infection and systemic microvascular leakage leading in some cases to high morbidity and mortality. Unfortunately, little is known about the molecular pathways triggered by these diseases in humans. We therefore analyzed how candidate cytokines co-occur across acutely-ill patients with either a localized (DEBONEL), or a systemic (MSF) form of rickettsiosis, using bipartite visual analytics. The results revealed a network core consisting of a small set of MSF patients exhibiting high expressions of cytokines implicated in microvascular leakage, endothelial repair, and pro-inflammatory immune responses, and a network periphery consisting of a mixture of MSF and DEBONEL patients with relatively lower overall cytokine expressions. These results provide evidence of pathways triggered by rickettsiae in humans, and a testable hypothesis for the mechanisms in a rickettsia-induced cytokine storm with the translational goal of identifying therapeutic targets.

Published
2013

43. Diagnosing emerging and reemerging infectious diseases: the pivotal role of the pathologist

Author

Olano, Juan P. and Walker, David H.

Subjects
United States. Food and Drug Administration -- Analysis, Biosecurity -- Analysis, Health
Abstract

Context.--Molecular diagnostics continues to evolve very rapidly, and its impact in the diagnosis of infectious diseases is undeniable. Molecular tools have played a pivotal role in discovering and characterizing several emerging infectious agents and have now become the gold standard for the diagnosis of infectious diseases caused by fastidious or uncultivable agents. Multiple challenges still remain for the widespread use of cost-effective, validated, and commercially available molecular tools. Automated instruments capable of sample processing and multiplex nucleic acid amplification and postamplification analysis have already been approved by the US Food and Drug Administration (FDA) for use in the clinical setting. Nanobiotechnology is beginning to impact laboratory diagnostics in the clinical setting. Objective.--To address current nucleic acid techniques used in the clinical laboratory for diagnosis of infectious diseases. FDA-approved tests are listed, as well as molecular techniques (amplification and postamplification analysis). A comprehensive list of emerging pathogens during the last 4 decades is also presented. Biosurveillance systems are discussed in the context of molecular tools. The rapidly evolving field of nanobiotechnology is briefly addressed. Data Sources.--Original publications, major reviews, and book chapters were used to present a comprehensive, yet short, review of molecular diagnostics in infectious diseases. Conclusions.--We will continue to witness an exponential growth of molecular techniques used for the initial diagnosis of infectious diseases. Molecular tools will also continue to have an impact on disease prognosis and response to therapeutic interventions. Automation, multiplexing, and miniaturization will continue to be driving forces in the development of new instruments. (Arch Pathol Lab Med. 2011;135:83-91), Despite the initial success in combating infectious diseases, first by vaccination, and later with antibiotics, emerging and reemerging infections will continue to challenge humankind owing to the unique nature of [...]

Published
2011

45. Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo

Author

Otterdal, Kari, primary, Portillo, Aránzazu, additional, Astrup, Elisabeth, additional, Ludviksen, Judith K., additional, Schjalm, Camilla, additional, Raoult, Didier, additional, Olano, Juan P., additional, Halvorsen, Bente, additional, Oteo, José A., additional, Aukrust, Pål, additional, Mollnes, Tom E., additional, and Nilsson, Per H., additional

Published
2016
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48. An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

Author

Soong, Lynn, primary, Mendell, Nicole L., additional, Olano, Juan P., additional, Rockx-Brouwer, Dedeke, additional, Xu, Guang, additional, Goez-Rivillas, Yenny, additional, Drom, Claire, additional, Shelite, Thomas R., additional, Valbuena, Gustavo, additional, Walker, David H., additional, and Bouyer, Donald H., additional

Published
2016
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49. Contributors

Author

Abraham, Naif Z., Jr., Aoyagi, Katsumi, Ashihara, Yoshihiro, Banki, Katalin, Beavis, Kathleen G., Bem, Sylva, Bluth, Martin H., Bock, Jay L., Borowitz, Michael J., Bowne, Wilbur B., Brandt-Rauf, Paul W., Briefel, Gary, Cai, Donghong, Caragher, Timothy E., Carty, Robert P., Chan, Edward K.L., Charnot-Katsikas, Angella, Chen, Xueying, Cherian, Sindu, Clapp, William L., Collinsworth, Amy L., Cooling, Laura, Costello, Michael, Davenport, Robertson, DeCresce, Robert, Delgado, Julio C., Downs, Theresa, Elghetany, M. Tarek, Elkins, Matthew, Fagoaga, Omar Roberto, Farag, Amal F., Fritsche, Thomas Richard, Fritzler, Marvin J., Gabali, Ali, Gleeson, Elizabeth, Graham, Susan S., Greco, Nicholas J., Grody, Wayne W., Guber, Helena A., Hall, Geraldine S., Hamilton, Robert G., Harris, Neil S., Hilbert, Tim, Hill, Charles E., Hirschhorn, Julie Woolworth, Homburger, Henry A., Huber, Sally A., Hussain, M. Mahmood, Hutchison, Robert E., Iwen, Peter C., Jain, Shilpa, Jeelani, Roohi, Jennette, J. Charles, Jenny, Nancy S., Jhang, Jeffrey S., Karcher, Donald S., Kasahara, Yasushi, Kessler, Craig M., Kidd, Jason, Klein, Michael J., Klemm, Katrin M., Kumánovics, Attila, Kurec, Anthony, LaDoulis, Charles, LaSala, P. Rocco, Lee, Peng, Lewis, Michael R., Li, Jing, Lifshitz, Mark S., Loeffelholz, Michael, Long, Patrick Michael, Massey, H. Davis, Mathur, Sharad C., Mazur, Lech J., McPherson, Richard A., McVoy, Lauren, Merkel, Kimberly L., Miller, Jonathan L., Miller, W. Greg, Mintz, Paul D., Mitsios, John V., Mohi, Golam, Nadkarni, Prashant, Napolitano, Mariasanta, Nolte, Frederick S., Oh, Man S., Olano, Juan P., Ortel, Thomas L., Patterson, Emily Rupp, Pincus, Matthew R., Piper, Margaret, Pritt, Bobbi S., Rand, Jacob H., Rao, A. Koneti, Riley, Roger S., Roby, Rhonda K., Rossi, Ralph, Salwen, Martin J., Sanford, Kimberly W., Sarafraz-Yazdi, Ehsan, Schexneider, Katherine I., Schmaier, Alvin H., Shaikh, Mohammad F., Siddiqi, Haseeb A., Stein, Constance K., Steinau, Martin, Tierno, Philip M., Jr., Tranchida, Paul, Unger, Elizabeth R., Vajpayee, Neerja, von Mühlen, Carlos Alberto, Walker, David H., Weimer, Eric T., Weindel, Michael, Weinstock, Ruth S., Winter, William E., Winters, Jeffrey L., Wood, Brent L., Woods, Gail L., Xu, Ruliang, Zhang, David Y., and Zhou, Liye

Published
2017
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50. Early diagnosis of Ehrlichia ewingii infection in a lung transplant recipient by peripheral blood smear.

Author

Regunath, Hariharan, Rojas‐Moreno, Christian, Olano, Juan P., Hammer, Richard D., and Salzer, William

Subjects
EHRLICHIOSIS, LUNG transplantation, TRANSPLANTATION of organs, tissues, etc., EHRLICHIA, CYTOPLASM
Abstract

Ehrlichiosis in lung transplant ( LT) recipients is associated with severe outcomes. Ehrlichia ewingii is a less frequent cause of symptomatic ehrlichiosis, characterized by cytoplasmic inclusions (morulae) within circulating neutrophils. We report a case of E. ewingii infection in an LT recipient diagnosed promptly by blood smear exam and confirmed with molecular studies. [ABSTRACT FROM AUTHOR]

Published
2017
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