94 results on '"Older cancer patients"'
Search Results
2. NUTMEG: A randomized phase II study of nivolumab and temozolomide versus temozolomide alone in newly diagnosed older patients with glioblastoma
- Author
-
Sim, Hao-Wen, Wachsmuth, Luke, Barnes, Elizabeth H, Yip, Sonia, Koh, Eng-Siew, Hall, Merryn, Jennens, Ross, Ashley, David M, Verhaak, Roel G, Heimberger, Amy B, Rosenthal, Mark A, Hovey, Elizabeth J, Ellingson, Benjamin M, Tognela, Annette, Gan, Hui K, Wheeler, Helen, Back, Michael, McDonald, Kerrie L, Long, Anne, Cuff, Katharine, Begbie, Stephen, Gedye, Craig, Mislang, Anna, Le, Hien, Johnson, Margaret O, Kong, Benjamin Y, Simes, John R, Lwin, Zarnie, and Khasraw, Mustafa
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Aging ,Rare Diseases ,Cancer ,Immunization ,Clinical Research ,Brain Cancer ,Clinical Trials and Supportive Activities ,Brain Disorders ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,clinical trials ,glioblastoma ,immunotherapy ,older cancer patients ,systemic therapy - Abstract
BackgroundThere is an immunologic rationale to evaluate immunotherapy in the older glioblastoma population, who have been underrepresented in prior trials. The NUTMEG study evaluated the combination of nivolumab and temozolomide in patients with glioblastoma aged 65 years and older.MethodsNUTMEG was a multicenter 2:1 randomized phase II trial for patients with newly diagnosed glioblastoma aged 65 years and older. The experimental arm consisted of hypofractionated chemoradiation with temozolomide, then adjuvant nivolumab and temozolomide. The standard arm consisted of hypofractionated chemoradiation with temozolomide, then adjuvant temozolomide. The primary objective was to improve overall survival (OS) in the experimental arm.ResultsA total of 103 participants were randomized, with 69 in the experimental arm and 34 in the standard arm. The median (range) age was 73 (65-88) years. After 37 months of follow-up, the median OS was 11.6 months (95% CI, 9.7-13.4) in the experimental arm and 11.8 months (95% CI, 8.3-14.8) in the standard arm. For the experimental arm relative to the standard arm, the OS hazard ratio was 0.85 (95% CI, 0.54-1.33). In the experimental arm, there were three grade 3 immune-related adverse events which resolved, with no unexpected serious adverse events.ConclusionsDue to insufficient evidence of benefit with nivolumab, the decision was made not to transition to a phase III trial. No new safety signals were identified with nivolumab. This complements the existing series of immunotherapy trials. Research is needed to identify biomarkers and new strategies including combinations.
- Published
- 2023
3. The Predictive Value of the G8 Questionnaire in Older Patients with Lung Cancer or Mesothelioma before Systemic Treatment.
- Author
-
Wu, X., Kumar, R., Milner-Watts, C., Walder, D., Battisti, N.M.L., Minchom, A., Bhosle, J., and O'Brien, M.E.R.
- Subjects
- *
MESOTHELIOMA , *DRUG tolerance , *CANCER chemotherapy , *RESEARCH methodology evaluation , *RESEARCH methodology , *FUNCTIONAL status , *LUNG tumors , *CANCER patients , *COMPARATIVE studies , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *PREDICTIVE validity , *DECISION making in clinical medicine , *LONGITUDINAL method , *ONCOLOGISTS , *EVALUATION , *OLD age - Abstract
The standard evaluation of older lung cancer or mesothelioma patients for systemic anti-cancer treatment, based on performance status, is inaccurate. We used the G8 questionnaire to assess a patient's fitness for chemotherapy and explored the correlations between G8 scores, treatment decisions and clinical outcomes. In total, 201 older patients (≥70 years) with advanced lung cancer or mesothelioma were prospectively assessed by standard clinical methods and a G8 questionnaire. Treatment decisions before and after reviewing the G8 score were documented. Patients were divided into low (<11), intermediate (11–14) and high (>14) G8 score groups. Patients' characteristics, treatment plans and clinical outcomes among each G8 score group were compared. Similar analyses were compared between good (<2) and poor (≥2) performance status. 10.1% of patients' treatment plans changed after oncologists reviewed G8 scores. The G8 score correlated inversely with performance status. More patients with low G8 scores (22.5%) were offered the best supportive care compared with 4.5% in intermediate and 1.9% in high G8 score groups. More patients (30.1%) with low G8 scores had treatment changed from chemotherapy to best supportive care on the planned day of their treatment, compared with intermediate (7.5%) and high (6.1%) G8 score groups. High G8 score patients received higher chemotherapy intensity and survived longer than patients with intermediate or low G8 scores. The G8 score with two cut-off values can predict functional status, chemotherapy tolerability and prognosis in older patients with lung cancer or mesothelioma, thus supporting oncologists on treatment decisions for this population. • The G8 scores correlate inversely with performance status. • Low G8 scores can predict a rapid functional decline of older patients with lung cancer or mesothelioma. • The G8 score with two cut-off values can predict chemotherapy tolerability and prognosis. • Our findings reinforce the clinical utility of the G8 scores to support oncologists on treatment decisions and chemotherapy intensity. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. Effectiveness of a digital telemonitoring platform for cancer care of older patients: The ConnectElderlyPatientToDoctor study.
- Author
-
Rivière, Clémentine, Brureau, Laurent, Parnot, Charles, Becherirat, Selma, Duverger, Claire, Picchi, Hugo, Le Roy, Audrey, Vuagnat, Perrine, Schernberg, Antoine, Vanquaethem, Hélène, and Helissey, Carole
- Subjects
DIGITAL technology ,CANCER patient care ,OUTPATIENT medical care ,PROGRESSION-free survival ,OLDER patients ,ADVERSE health care events ,MEDICAL care surveys - Abstract
While telemedicine has been shown to improve the quality of care for cancer patients, it remains underused for older patients (OP), partly due to the assumption that OPs are unabled or unwilling to use digital tools. However, more than 50% of new cancers are diagnosed in people over 70. The ConnectElderlyPatientToDoctor study aimed to evaluate the OP compliance with the use of the digital telemonitoring platform Cureety in oncology. All cancer patients followed at the Military Hospital Bégin were eligible for the study. Patients were invited to respond to a symptomatology questionnaire personalized to their pathology and treatment. An algorithm evaluated the health status of the patient based on the reported adverse events. The population was divided into two groups, OP and younger patients (YP), based on a cut‐off at 70 years. The primary endpoint was to assess the compliance of OPs with the use of the digital oncology platform Cureety, compared to YP. From July 2020 to September 2021, a total of 117 patients were included in our study. We found that 66% of the patients were compliant, with no difference between the two groups (71.2% of YP, 61.7% of OP, P =.29). In OPs, progression free survival (PFS) ratio at 6‐months was 64.6% in the tolerant patients vs 23.4% in the nontolerant patients (HR = 0.1980, 95% CI = 0.04431‐0.8845, P =.0339). The median PFS was 23.3 months in the tolerant group vs 3.3 months in the nontolerant group (P =.0339). The data of overall survival are immature. OPs had a clear benefit from using this platform, similar to what was observed for YP. Patients felt less isolated and felt that they benefited from personalized care with early ambulatory medical care of adverse events. We also found that the health indicators collected with the platform in the first month of treatment are predictive of the progression of the disease. This solution makes it possible to streamline and improve the care pathway of OP. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Survival of Critically Ill Older Patients with Haematological Malignancies.
- Author
-
Judickas, Sarunas, Stasiunaitis, Raimundas, Zucenka, Andrius, Zvirblis, Tadas, Serpytis, Mindaugas, and Sipylaite, Jurate
- Subjects
INTENSIVE care units ,SCIENTIFIC observation ,ACADEMIC medical centers ,CRITICALLY ill ,PATIENTS ,APACHE (Disease classification system) ,CANCER patients ,HOSPITAL admission & discharge ,HEMATOLOGIC malignancies ,VASCULAR diseases ,LONGITUDINAL method ,HEART failure ,OLD age - Abstract
Background: For a significant majority of cancers age is a major risk factor. The aim of our study was to investigate survival of older patients admitted to an intensive care unit (ICU) with underlying haematological malignancy and compare them to younger patients. Matherials and methods: A prospective observational study was carried out in Vilnius University Hospital Santaros Klinikos from2017 to 2019. Patients were categorized into two groups: younger (< 65 years) and older (≥ 65 years), depending on age on admission to ICU. Results: 114 patients were included in the study. There were 61 (53.51%) patients in the younger patient group and 53 (46.49%) patients in the older patient group. The older patient group had more chronic heart failure (34.0% vs. 11.5%), vascular disease (67.9% vs. 21.3%), poor physical performance status (39.6% vs. 13.1%) and higher APACHE II scores (23.34 vs. 20.31). Younger patients more often received intensive chemotherapy (57.4% vs. 39.6%). The proportion of patients for whom SOFA score increased over the first 48 hours in ICU also qSOFA and SOFA scores did not differ between the groups. Both groups received the same amount of organ support therapies such as vasopressors, invasive mechanical ventilation, and renal replacement therapy. We found that age did not influence survival of the patients as there was no difference in ICU, 30 days and overall mortality between the groups. Conclusion: Age group does not influence survival of critically ill oncohaematological patients, and it shouldn’t be the criteria for eligibility to the ICU. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
6. Improving the experience of older people with colorectal and breast cancer in patient‐centred cancer care pathways using experience‐based co‐design
- Author
-
Albine Moser, Inge Melchior, Marja Veenstra, Esther Stoffers, Elvira Derks, and Kon‐Siong Jie
- Subjects
breast cancer ,cancer care pathways ,caregivers ,colorectal cancer ,experience‐based co‐design ,older cancer patients ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Patient and public involvement (PPI) in quality improvement of oncological care pathways for older patients are rare. Objectives Improve the care pathway experience of older cancer patients and explore lessons learned regarding how to engage this vulnerable group. Design Experience‐Based Co‐Design. Setting and participants: Older cancer patients, their caregivers and healthcare professionals within colorectal and breast cancer care pathways. Interventions: Co‐design quality improvement teams. Main outcome measures: Colorectal cancer care pathway touchpoints were (a) availability of a contact person during diagnostic, treatment and aftercare phases; (b) collaboration between physicians and different hospital departments; (c) continuous relationship with same physician; (d) respectful treatment; (e) and information transfer with primary care. Breast cancer care pathway touchpoints were (a) comprehensive information package and information provision, (b) care planning based on patient preferences, (c) continuity of patient–professional relationship and (d) specialized care in case of vulnerability. Challenges related to PPI included (a) ability of older cancer patients to be reflective, critical and think at a collective level; (b) gaining support and commitment of professionals; (d) overcoming cultural differences and power inequalities; and (e) involving researchers and facilitators with appropriate expertise and position. Conclusion This multidisciplinary quality improvement project revealed several challenges of PPI with older cancer patients and their caregivers. Research teams themselves need to assume the role of facilitator to enable meaningful PPI of older cancer patients. Patient or Public Contribution Patient and caregiver representatives and advocates were involved in the design, conduct, analysis, interpretation of the data and preparation of this manuscript.
- Published
- 2021
- Full Text
- View/download PDF
7. Validation of uHear™ as a Screening Tool to Detect Hearing Impairment in Older Cancer Patients Within a Comprehensive Geriatric Assessment - BIS (UHEAR-BIS)
- Author
-
Dr. Philip Debruyne, Medical Oncologist
- Published
- 2018
8. Screening for Frailty Using the FRAIL Scale in Older Cancer Survivors: A Cross-sectional Comparison With the Fried Phenotype.
- Author
-
Cheung, Denise Shuk Ting, Ho, Mu-Hsing, Chau, Pui Hing, Yu, Doris Sau Fung, Chan, Wing Lok, Soong, Sung Inda, Woo, Jean, and Lin, Chia Chin
- Abstract
To examine the diagnostic performance of the FRAIL Scale for frailty screening with reference to the Fried phenotype and investigate its association with health outcomes in older cancer survivors. In this cross-sectional quantitative study, participants were post-treatment cancer survivors aged 65 or above. Measurements included the FRAIL Scale, Fried phenotype, Geriatric Depression Scale-15 item, Modified Barthel Inventory, and EORTC Core Quality of Life Questionnaire. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic performance of the FRAIL Scale with reference to the Fried phenotype. Health outcomes associated with being frail as estimated by the FRAIL Scale and Fried phenotype were also examined using regressions. Based on 293 older cancer survivors, the area under curve (AUC) of the FRAIL Scale was 0.79, and the optimal cut-off of 1 yielded a sensitivity of 92% and specificity of 41%. According to regression results, the FRAIL Scale was modified by adding an item on time since cancer treatment completion (AUC = 0.81), and using a cut-off of 2 for older cancer survivors, which yielded a sensitivity of 74% and specificity of 67%. The modified FRAIL Scale was associated with depressive symptoms, functional independence, fatigue, dyspnea, physical functioning, and role functioning. The modified FRAIL Scale is proposed for use in older cancer survivors, and a cut-off of 2 should be used. The modified FRAIL Scale can serve as a brief screening tool for identifying frailty among older cancer survivors in practice. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Enrolment of older adults with cancer in early phase clinical trials—an observational study on the experience in the north west of England.
- Author
-
Gomes, Fabio, Descamps, Tine, Lowe, Jessica, Little, Martin, Lauste, Rosie, Krebs, Matthew G, Graham, Donna, Thistlethwaite, Fiona, Carter, Louise, and Cook, Natalie
- Subjects
- *
HUMAN research subjects , *CLINICAL trials , *SCIENTIFIC observation , *SPECIALTY hospitals , *PATIENT selection , *RETROSPECTIVE studies , *CANCER patients , *CANCER treatment , *DESCRIPTIVE statistics , *LONGITUDINAL method , *OLD age - Abstract
Introduction older patients represent the majority of cancer patients but are under-represented in trials, particularly early phase clinical trials (EPCTs). Material and Methods observational retrospective study of patients referred for EPCTs (January–December 2018) at a specialist cancer centre in the UK. The primary aim was to analyse the successful enrolment into EPCTs according to age (<65/65+). The secondary aims were to identify enrolment obstacles and the outcomes of enrolled patients. Patient data were analysed at: referral; in-clinic assessment and after successful enrolment. Among patients assessed in clinic, a sample was defined by randomly matching the older cohort with the younger cohort (1:1) by tumour type. Results 555 patients were referred for EPCTs with a median age of 60 years, of whom 471 were assessed in new patient clinics (38% were 65+). From those assessed, a randomly tumour-matched sample of 318 patients (159 per age cohort) was selected. Older patients had a significantly higher comorbidity score measured by ACE-27 (P < 0.0001), lived closer to the hospital (P = 0.045) and were referred at a later point in their cancer management (P = 0.002). There was no difference in suitability for EPCTs according to age with overall 84% deemed suitable. For patients successfully enrolled into EPCTs, there was no difference between age cohorts (20.1 vs. 22.6% for younger and older, respectively; P = 0.675) and no significant differences in their safety and efficacy outcomes. Discussion older age did not affect the enrolment into EPCTs. However, the selected minority referred for EPCTs suggests a pre-selection upstream by primary oncologists. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
10. Rehabilitation Treatment in Older Cancer Patients
- Author
-
Brunello, Antonella, Lombardi, Giuseppe, Zagonel, Vittorina, Maggi, Stefania, Series editor, Masiero, Stefano, editor, and Carraro, Ugo, editor
- Published
- 2018
- Full Text
- View/download PDF
11. The role of family confidants and caregivers in the care of older cancer patients: Extending the concept of 'shared decision‐making'
- Author
-
Frank Gieseler, Andreas Heidenreich, Jacqueline Schubert, Fabian Frielitz, Christoph Rehmann‐Sutter, Frank Wörler, Christina Schües, Joachim Hübner, Susanne Elsner, Katarina Block, Achim Rody, Nikolas vonBubnoff, Tobias Keck, Monika Steimann, Gero Endsin, and Alexander Katalinic
- Subjects
family ,older cancer patients ,qualitative research methods ,quality of life ,survivorship ,Medicine - Abstract
Abstract Background and aims Family caregivers play an important role in assisting their family members with cancer, but their influence on the treatment decision‐making process has not yet been adequately investigated. This exploratory study approached this topic via reconstructive methodology, focusing on assessing patient‐caregiver relationships. Methods We conducted semi‐structured interviews with 37 mostly elderly cancer patients (median age: 74 years) about the context of their diagnosis, treatment decision, and family support. Additionally, we interviewed 34 caregivers of cancer patients. Of these, 25 were related to patients interviewed. We analyzed the interviews via a multi‐step coding method informed by Grounded Theory methodology toward characterizing patient‐caregiver relationships, the treatment decision‐making process, and the caregivers' role therein. Results In the majority of cases (86%), patients were being supported by caregivers. We categorized patient‐caregiver relationships in regards to the caregivers' involvement in the therapy decision‐making process. We found patient‐caregiver interaction patterns that indicate the potential of caregivers to decidedly influence the therapy decision‐making process. Yet, only in 38% of cases, a caregiver attended relevant patient‐physician‐consultations. Conclusion Depending on the nature of the patient‐caregiver relationship, the traditional concept of shared decision‐making, which assumes a dyadic relationship, needs to be extended toward a more dynamic concept in which caregivers should be involved more frequently. This could enable physicians to better understand a patient's reasons for or against a therapy proposal and ensure that the patient's wishes are communicated and considered. On the other hand, strong caregiver‐involvement bears risks of over‐stepping elderly patients' wishes, thus violating patient autonomy.
- Published
- 2021
- Full Text
- View/download PDF
12. The effect of treatment modifications by an onco-geriatric MDT on one-year mortality, days spent at home and postoperative complications.
- Author
-
Festen, Suzanne, van der Wal-Huisman, Hanneke, van der Leest, Annya H.D., Reyners, Anna K.L., de Bock, Geertruida H., de Graeff, Pauline, and van Leeuwen, Barbara L.
- Abstract
Decision-making in older patients with cancer can be complex, as benefits of treatment should be weighed against possible side-effects and life-expectancy. A novel care pathway was set up incorporating geriatric assessment into treatment decision-making for older cancer patients. Treatment decisions could be modified following discussion in an onco-geriatric multidisciplinary team (MDT). We assessed the effect of treatment modifications on outcomes. This retrospective study was performed in the surgical department of a University Hospital. Patients of 70 years and older with a solid malignancy were included. All patients underwent a nurse-led geriatric assessment (GA) and were discussed in an onco-geriatric MDT. This could result in a modified or an unchanged treatment advice compared to the regular tumor board. Primary outcome was one-year mortality. Secondary outcomes were post-operative complications and days spent in hospital in the first year after inclusion. For the 184 patients in the analyses, the median age was 77.5 years and 41.8% were female. For 46 patients (25%), the treatment advice was modified by the onco-geriatric MDT. There was no significant difference in one-year mortality between the unchanged and modified group (29.7% versus 26.1%, p = 0.7). There were, however, significantly fewer days spent in hospital (median 5 vs 8.5 days p = 0.02) and fewer grade II or higher postoperative complications (13.3% versus 35.5% p = 0.005) in the modified group. Incorporating geriatric assessment in decision-making did not lead to excess one-year mortality, but did result in fewer complications and days spent in hospital. • Incorporating geriatric assessment led to a modified treatment advice in 25% of patients. • Modifications were mostly toward less intensive treatment. • Follow-up revealed no excess one-year mortality compared to patients with an unchanged advice. • The modified group experienced less complications and less days spent in hospital. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
13. The role of family confidants and caregivers in the care of older cancer patients: Extending the concept of “shared decision‐making”.
- Author
-
Gieseler, Frank, Heidenreich, Andreas, Schubert, Jacqueline, Frielitz, Fabian, Rehmann‐Sutter, Christoph, Wörler, Frank, Schües, Christina, Hübner, Joachim, Elsner, Susanne, Block, Katarina, Rody, Achim, von Bubnoff, Nikolas, Keck, Tobias, Steimann, Monika, Endsin, Gero, and Katalinic, Alexander
- Abstract
Background and aims: Family caregivers play an important role in assisting their family members with cancer, but their influence on the treatment decision‐making process has not yet been adequately investigated. This exploratory study approached this topic via reconstructive methodology, focusing on assessing patient‐caregiver relationships. Methods: We conducted semi‐structured interviews with 37 mostly elderly cancer patients (median age: 74 years) about the context of their diagnosis, treatment decision, and family support. Additionally, we interviewed 34 caregivers of cancer patients. Of these, 25 were related to patients interviewed. We analyzed the interviews via a multi‐step coding method informed by Grounded Theory methodology toward characterizing patient‐caregiver relationships, the treatment decision‐making process, and the caregivers' role therein. Results: In the majority of cases (86%), patients were being supported by caregivers. We categorized patient‐caregiver relationships in regards to the caregivers' involvement in the therapy decision‐making process. We found patient‐caregiver interaction patterns that indicate the potential of caregivers to decidedly influence the therapy decision‐making process. Yet, only in 38% of cases, a caregiver attended relevant patient‐physician‐consultations. Conclusion: Depending on the nature of the patient‐caregiver relationship, the traditional concept of shared decision‐making, which assumes a dyadic relationship, needs to be extended toward a more dynamic concept in which caregivers should be involved more frequently. This could enable physicians to better understand a patient's reasons for or against a therapy proposal and ensure that the patient's wishes are communicated and considered. On the other hand, strong caregiver‐involvement bears risks of over‐stepping elderly patients' wishes, thus violating patient autonomy. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
14. Improving the experience of older people with colorectal and breast cancer in patient‐centred cancer care pathways using experience‐based co‐design.
- Author
-
Moser, Albine, Melchior, Inge, Veenstra, Marja, Stoffers, Esther, Derks, Elvira, and Jie, Kon‐Siong
- Subjects
- *
COLON tumors , *PATIENT-centered care , *EXPERIENCE , *QUALITY assurance , *BREAST tumors ,RECTUM tumors - Abstract
Background: Patient and public involvement (PPI) in quality improvement of oncological care pathways for older patients are rare. Objectives: Improve the care pathway experience of older cancer patients and explore lessons learned regarding how to engage this vulnerable group. Design: Experience‐Based Co‐Design. Setting and participants: Older cancer patients, their caregivers and healthcare professionals within colorectal and breast cancer care pathways. Interventions: Co‐design quality improvement teams. Main outcome measures: Colorectal cancer care pathway touchpoints were (a) availability of a contact person during diagnostic, treatment and aftercare phases; (b) collaboration between physicians and different hospital departments; (c) continuous relationship with same physician; (d) respectful treatment; (e) and information transfer with primary care. Breast cancer care pathway touchpoints were (a) comprehensive information package and information provision, (b) care planning based on patient preferences, (c) continuity of patient–professional relationship and (d) specialized care in case of vulnerability. Challenges related to PPI included (a) ability of older cancer patients to be reflective, critical and think at a collective level; (b) gaining support and commitment of professionals; (d) overcoming cultural differences and power inequalities; and (e) involving researchers and facilitators with appropriate expertise and position. Conclusion: This multidisciplinary quality improvement project revealed several challenges of PPI with older cancer patients and their caregivers. Research teams themselves need to assume the role of facilitator to enable meaningful PPI of older cancer patients. Patient or Public Contribution: Patient and caregiver representatives and advocates were involved in the design, conduct, analysis, interpretation of the data and preparation of this manuscript. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
15. Treatment decision-making for older adults with cancer: A qualitative study.
- Author
-
Gong, Ni, Du, Qianqian, Lou, Hongyu, Zhang, Yiheng, Fang, Hengying, Zhang, Xueying, Wu, Xiaoyu, Meng, Ya, and Zhang, Meifen
- Subjects
- *
TUMOR treatment , *PATIENT decision making , *RESEARCH methodology , *INTERVIEWING , *QUALITATIVE research , *CANCER patients , *PATIENT-family relations , *DECISION making , *RESEARCH funding , *THEMATIC analysis , *JUDGMENT sampling , *OLD age - Abstract
Background: Independent decision-making is one of the basic rights of patients. However, in clinical practice, most older cancer patients' treatment decisions are made by family members. Objective: This study attempted to analyze the treatment decision-making process and formation mechanism for older cancer patients within the special cultural context of Chinese medical practice. Method: A qualitative study was conducted. With the sample saturation principle, data collected by in-depth interviews with 17 family members and 12 patients were subjected to thematic analysis. Ethical considerations: The study was approved by the ethics committees of Sun Yat-sen University. All participants provided verbal informed consent after being told their rights of confidentiality, anonymity, and voluntary participation. They had the right to refuse to answer questions and could withdraw at any time. Results: Three themes emerged: (1) complex process; (2) transformation of family decision-making power; and (3) individual compromise. Family members inevitably had different opinions during the long process of treatment decision-making for older cancer patients. The direction of this process could be regarded as an extension of the family power relationship. The patient usually compromised the decision to survive, which was made by family members. Conclusion: This study describes the treatment decision-making process of older cancer patients in the context of Chinese culture. The reasons underlying this process are related to the views on life and death and family values. An individual is a part of the family, which is often seen as the minimal interpersonal unit in Chinese society. It is significant that while emphasizing patient autonomy in the decision-making process, health professionals should also pay attention to the important roles of culture and family. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
16. CT Derived Muscle Measures, Inflammation, and Frailty in a Cohort of Older Cancer Patients.
- Author
-
HARNESHAUG, MAGNUS, BENTH, JURATE SALTYTE, KIRKHUS, LENE, GRONBERG, BJORN HENNING, BERGH, SVERRE, ROSTOFT, SIRI, and SLAAEN, MARIT
- Subjects
CANCER patients ,GERIATRIC assessment ,MUSCLE measurement ,MYOSITIS ,CANCER prognosis ,C-reactive protein ,ALBUMINS - Abstract
Background/Aim: Muscle loss, inflammation, and frailty are prevalent among older cancer patients. We aimed to evaluate whether inflammatory markers could identify muscle loss, and if muscle measures differed between frail and non-frail patients. Patients and Methods: A total of 115 patients ≥70 years old with solid tumors were included. Inflammation was measured using the Glasgow Prognostic Score (GPS), which is based on C-reactive protein (CRP) and albumin levels, and CRP alone. Frailty was evaluated using a modified geriatric assessment (mGA) of eight domains affecting older patients’ health status. Computed tomography-derived muscle measures were collected at the level of the third lumbar vertebra. Results: Patients with GPS=2 and CRP>27 mg/l exhibited poorer muscle measures compared to patients with lower levels. No associations between mGA-based frailty and muscle mass were found. Conclusion: Inflammation has detrimental effects on muscle. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
17. Comparing the performance of the CARG and the CRASH score for predicting toxicity in older patients with cancer.
- Author
-
Ortland, Imke, Mendel Ott, Monique, Kowar, Michael, Sippel, Christoph, Jaehde, Ulrich, Jacobs, Andreas H., and Ko, Yon-Dschun
- Abstract
To compare the CARG (Cancer and Aging Research Group) and CRASH (Chemotherapy Risk Assessment Scale for High-Age Patients) score regarding the predictive performance for severe toxicity in older patients with cancer. We recruited patients ≥70 years and applied the CARG and CRASH score before the start of systemic cancer treatment. The CARG predicts severe overall toxicity; the CRASH additionally predicts hematologic and nonhematologic toxicity. We captured ≥ grade 3 toxicity according to Common Terminology Criteria for Adverse Events (CTCAE) from medical records. Predictive performance was assessed using logistic regression and the area under the receiver operating characteristic curve (ROC-AUC). The study cohort comprised 120 patients (50% female, mean age 77.2 years, 57% solid tumors). The median of the CARG (range 0–23) and the combined CRASH (range 0–12) were 9 and 8, respectively. 81% of patients experienced toxicity; 67% showed hematologic toxicity. The predictive performance of the CARG and the combined CRASH was similar for overall toxicity (CARG: Odds ratio per unit increase (OR) 1.266, P =.015; ROC-AUC 0.681, P =.010; combined CRASH: OR 1.337, P =.029; ROC-AUC 0.650, P =.032). For hematologic toxicity, the hematologic CRASH was a significant predictor and showed numerically a higher ROC-AUC than the CARG which was not statistically different (CARG: OR 1.048, P =.462; ROC-AUC 0.564, P =.271; hematologic CRASH: OR 1.602, P =.007; ROC-AUC 0.665, P =.005). Both scores exhibited similar predictive performance for toxicity in older patients with cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
18. Access to information and counselling – older cancer patients’ self-report: a cross-sectional survey
- Author
-
Kristin Vassbotn Guldhav, Randi Jepsen, Siri Ytrehus, and Ellen Karine Grov
- Subjects
Older cancer patients ,Information ,Counselling ,Home care nursing ,Cancer coordinator ,Nursing ,RT1-120 - Abstract
Abstract Background An increasingly older population, improved diagnostics and treatment increase the number of older cancer survivors, thus more than 60% of those affected by cancer are over the age of 65. Symptom relief and the prevention of functional impairment are important tasks for home care nursing, considering that patients can live a long time with their cancer disease and related side effects. The aim of this study was to investigate the extent to which cancer patients over the age of 65 reported access to information and counselling from home care nursing services, including those offered by the cancer coordinator. Methods A cross-sectional survey was used. The survey consisted of 174 cancer patients from two regions in Norway living at home (101 women; 66–92 years). The questionnaire contained questions of various sequences including information and advices given and data on access to and use of home health care services. The questions focused on the extent to which home health care services provided the following: 1) information about the disease and treatment, 2) information about consequences and complications of the cancer disease, 3) nutritional advice and 4) advice on physical activity. Demographic, clinical and organizational variables were used. SPSS program version 22 was employed to perform descriptive and inferential statistics including correlation and logistic regression analysis. For ethical reasons, patients who were dying, delirious or with presence of cognitive impairment (any kind of dementia) were excluded. Results The results showed that a majority (67–77%) of the respondents reported low levels of information and counselling offered. Low levels represents in this study medium, small and very small degree (Likert scale). Women, those above 85 years of age and patients with a gynecological or hematological cancer diagnosis experienced less access to information and counselling. Respondents facing availability of a cancer coordinator reported significantly higher access to information about the disease and treatment (p = 0.03), nutritional advice (p = 0.04) and advice on physical activity (p = 0.04) compared to those who only had contact with a home health care nurse or home health care assistant. Conclusions The results indicated that the availability of a cancer coordinator facilitated personalized information and counselling for older cancer patients.
- Published
- 2017
- Full Text
- View/download PDF
19. Different Impact of Definitions of Sarcopenia in Defining Frailty Status in a Population of Older Women with Early Breast Cancer
- Author
-
Andrea Bellieni, Domenico Fusco, Alejandro Martin Sanchez, Gianluca Franceschini, Beatrice Di Capua, Elena Allocca, Enrico Di Stasio, Fabio Marazzi, Luca Tagliaferri, Riccardo Masetti, Roberto Bernabei, and Giuseppe Ferdinando Colloca
- Subjects
sarcopenia ,physical performance ,frailty ,older cancer patients ,Medicine - Abstract
Sarcopenia is a geriatric syndrome characterized by losses of quantity and quality of skeletal muscle, which is associated with negative outcomes in older adults and in cancer patients. Different definitions of sarcopenia have been used, with quantitative data more frequently used in oncology, while functional measures have been advocated in the geriatric literature. Little is known about the correlation between frailty status as assessed by comprehensive geriatric assessment (CGA) and sarcopenia in cancer patients. We retrospectively analyzed data from 96 older women with early breast cancer who underwent CGAs and Dual X-ray Absorptiometry (DXA) scans for muscle mass assessment before cancer treatment at a single cancer center from 2016 to 2019 to explore the correlation between frailty status as assessed by CGA and sarcopenia using different definitions. Based on the results of the CGA, 35 patients (36.5%) were defined as frail. Using DXA Appendicular Skeletal Mass (ASM) or the Skeletal Muscle Index (SMI=ASM/height^2), 41 patients were found to be sarcopenic (42.7%), with no significant difference in prevalence between frail and nonfrail subjects. Using the European Working Group on Sarcopenia in Older People (EWGSOP2) definition of sarcopenia (where both muscle function and mass are required), 58 patients were classified as “probably” sarcopenic; among these, 25 were sarcopenic and 17 “severely” sarcopenic. Only 13 patients satisfied both the requirements for being defined as sarcopenic and frail. Grade 3-4 treatment-related toxicities (according to Common Terminology Criteria for Adverse Events) were more common in sarcopenic and frail sarcopenic patients. Our data support the use of a definition of sarcopenia that includes both quantitative and functional data in order to identify frail patients who need tailored treatment.
- Published
- 2021
- Full Text
- View/download PDF
20. Chronic cardiovascular toxicity in the older oncology patient population.
- Author
-
Findlay, Simon G., Gill, Jason H., Plummer, Ruth, DeSantis, Carol, and Plummer, Chris
- Abstract
Survivorship statistics demonstrate that the incidence of cancer continues to rise worldwide, with a further 60% increase in diagnoses predicted by 2030 attributed to lifestyle risk factors, screening programmes resulting in earlier diagnosis but also the changing demographics of the population. More than a third of new cancer diagnoses and almost half of cancer survivors are now aged 70 years or older. Despite this increasing incidence, worldwide five-year cancer survival rates have improved significantly over the past two decades. After cancer, cardiovascular disease is the second most common cause of death in developed countries. With continued improvements in overall prognosis, patients with cancer have an increased exposure to cardiovascular risk factors resulting in higher cardiovascular morbidity and mortality, particularly in older patients. This relationship between cancer and cardiovascular disease is not surprising as they share the common risk factors of aging, smoking, obesity, and poor diet. In this review, we discuss the toxicity of cancer treatments on the cardiovascular system, particularly in older patients. We focus primarily on radiotherapy and anthracycline chemotherapy because of their chronic adverse effects and appraise approaches toward the detection and treatment of this toxicity to maximise survival and quality of life of older patients with cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
21. Comorbidity, Disability, and Geriatric Syndromes
- Author
-
Kristjansson, Siri Rostoft, Papamichael, Demetris, editor, and Audisio, Riccardo A., editor
- Published
- 2013
- Full Text
- View/download PDF
22. Oncogeriatrics (part 8.): Frailty screening tools.
- Author
-
Kenig, Jakub
- Subjects
- *
OLDER patients , *CANCER patients , *ABDOMINAL cancer , *METASTASIS , *RADIOTHERAPY - Abstract
Various frailty screening tools have been developed. However, there is currently no single ideal model; some scores are better for population-level, whereas others are best suited for clinical screening and preoperative assessment. Therefore, the choice of the score might relay on specific clinical condition, the aim of the tool and department resources. The G8 and the aCGA seem to be the the most suitable in the case of preoperative frailty assessments of older patients with solid abdominal cancer who are undergoing high-risk surgery. They also may be used to identify patients at risk for adverse postoperative outcomes. They may support the decision process particularly in situations of lack of experience in full Geriatric Assessment (easy to master and implement), in acute admitted patients (time pressure or some of the domains cannot be assessed) and in case of low-/moderate-risk surgery (where extensive frailty evaluation may not influence the postoperative outcome). [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
23. The effect of adjuvant chemotherapy on symptom burden and quality of life over time; a preliminary prospective observational study using individual data of patients aged ≥ 70 with early stage invasive breast cancer.
- Author
-
Quinten, Chantal, Kenis, C., Hamaker, M., Coolbrandt, A., Brouwers, B., Dal Lago, L., Neven, P., Vuylsteke, P., Debrock, G., Van Den Bulck, H., Smeets, A., Schöffski, P., Bottomley, A., Wedding, U., and Wildiers, H.
- Abstract
Objectives We aim to assess short and long term effects of chemotherapy on patient-reported quality of life (QOL) and patient versus clinician symptom reporting in older patients with breast cancer adjusted for tumour and aging parameters. Material and Methods In this prospective, multicentre, non-interventional, observational study, women aged ≥ 70 years were enrolled after surgery and assigned to a TC chemotherapy (docetaxel and cyclophosphamide) group or a control group depending on their planned adjuvant treatment. Longitudinal multivariate models were used to assess the statistical and minimal clinically important difference (MCID) in the impact of TC chemotherapy over time on QOL and symptom burden adjusted for baseline aging and tumour parameters. Statistical significance was set at 5% and MCID at 10 points. Results In total, 57 patients were enrolled in the chemotherapy and 52 patients in the control group. Within the chemotherapy group, clinical deterioration was reported at 3 months for Fatigue (17.73), Dyspnoea (17.05), Diarrhoea (12.06) and Appetite Loss (17.05) scores (all p < 0.001). However, the scores had returned to baseline (or even better for Role Functioning) at year 1. No clinical deterioration was reported in the control group. Symptom scores as reported by patients were significantly (p < 0.05) higher than those reported by the clinicians, even more so for Fatigue, Dyspnoea, and Pain. Conclusion Our results show that symptom burden and diminished QOL in an older breast cancer population receiving adjuvant TC chemotherapy are short-lived and disappear after a while with no long-term differences compared to a similar population not receiving chemotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
24. Effectiveness of a digital telemonitoring platform for cancer care of older patients: The ConnectElderlyPatientToDoctor study
- Author
-
Clémentine Rivière, Laurent Brureau, Charles Parnot, Selma Becherirat, Claire Duverger, Hugo Picchi, Audrey Le Roy, Perrine Vuagnat, Antoine Schernberg, Hélène Vanquaethem, Carole Helissey, Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and École des Hautes Études en Santé Publique [EHESP] (EHESP)
- Subjects
Cancer Research ,Oncology ,quality of life ,[SDV]Life Sciences [q-bio] ,telemonitoring ,older cancer patients - Abstract
International audience; While telemedicine has been shown to improve the quality of care for cancer patients, it remains underused for older patients (OP), partly due to the assumption that OPs are unabled or unwilling to use digital tools. However, more than 50% of new cancers are diagnosed in people over 70. The ConnectElderlyPatientToDoctor study aimed to evaluate the OP compliance with the use of the digital telemonitoring platform Cureety in oncology. All cancer patients followed at the Military Hospital Begin were eligible for the study. Patients were invited to respond to a symptomatology questionnaire personalized to their pathology and treatment. An algorithm evaluated the health status of the patient based on the reported adverse events. The population was divided into two groups, OP and younger patients (YP), based on a cut-off at 70 years. The primary endpoint was to assess the compliance of OPs with the use of the digital oncology platform Cureety, compared to YP. From July 2020 to September 2021, a total of 117 patients were included in our study. We found that 66% of the patients were compliant, with no difference between the two groups (71.2% of YP, 61.7% of OP, P = .29). In OPs, progression free survival (PFS) ratio at 6-months was 64.6% in the tolerant patients vs 23.4% in the nontolerant patients (HR = 0.1980, 95% CI = 0.04431-0.8845, P = .0339). The median PFS was 23.3 months in the tolerant group vs 3.3 months in the nontolerant group (P = .0339). The data of overall survival are immature. OPs had a clear benefit from using this platform, similar to what was observed for YP. Patients felt less isolated and felt that they benefited from personalized care with early ambulatory medical care of adverse events. We also found that the health indicators collected with the platform in the first month of treatment are predictive of the progression of the disease. This solution makes it possible to streamline and improve the care pathway of OP.
- Published
- 2022
25. Further psychometric validation of the GAH scale: Responsiveness and effect size.
- Author
-
Cruz-Jentoft, Alfonso José, González, Bernardo, de la Rubia, Javier, Hernández Rivas, José Ángel, Soler, Juan Alfonso, Fernández Lago, Carlos, Arnao, Mario, Gironella, Mercedes, Pérez Persona, Ernesto, Zudaire, María Teresa, Olivier, Carmen, Altés, Alberto, García Guiñón, Antonio, Nomdedeu, Benet, Arnan, Montserrat, Ramírez Payer, Ángel, Sánchez-Godoy, Pedro, Pajuelo, Nuria, Vilanova, David, and Monjil, Diego Fernánez
- Abstract
Objectives The purpose of this study was to assess the responsiveness of the newly developed Geriatric Assessment in Hematology (GAH) scale to clinical change in older patients diagnosed with hematologic malignancies. Methods A prospective observational study conducted in 164 patients aged ≥ 65 years and diagnosed with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML), multiple myeloma (MM), or chronic lymphocytic leukemia (CLL). Responsiveness of the GAH scales was studied by means of the Eastern Cooperative Oncology Group (ECOG) score, the Karnofsky performance status (KPS) score, the visual analog scale (VAS), and the physician's subjective assessment, used as clinical anchors to identify whether patients had changed clinically (either improved or worsened) or not since the baseline visit. Responsiveness was evaluated on the basis of effect size (ES). Results 164 patients (men, 63.7%; median age, 77.0 (72.8–81.4) participated. Statistically significant correlations were obtained between the investigator's qualitative assessment and changes in ECOG, KPS, and VAS scores. Likewise, a statistically significant correlation was obtained between the investigator's qualitative assessment and changes in the GAH scale score. Responsiveness of the GAH scale to detect clinical change was satisfactory (ES 0.34). Conclusion Findings confirm that the GAH scale is responsive to clinical changes in patients' health status. Additionally, the GAH scale is a promising tool to improve clinical decision-making in older patients with hematological malignancies. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
26. Impaired mobility, depressed mood, cognitive impairment and polypharmacy are independently associated with disability in older cancer outpatients: The prospective Physical Frailty in Elderly Cancer patients (PF-EC) cohort study.
- Author
-
Pamoukdjian, Frederic, Aparicio, Thomas, Zelek, Laurent, Boubaya, Marouane, Caillet, Philippe, François, Veronique, de Decker, Laure, Lévy, Vincent, Sebbane, Georges, and Paillaud, Elena
- Abstract
Objective To assess the prevalence of disability and the oncologic factors associated with disability in older outpatients with cancer. Materials and Methods The Physical Frailty in Elderly Cancer patients (PF-EC) study (France) is a prospective bicentric observational cohort study. Two hundred and ninety outpatients with cancer were included. A cross-sectional analysis of oncologic factors and geriatric variables associated with disability that were collected using a comprehensive geriatric assessment (CGA) was conducted. Disability was defined as impairment in activities of daily living (ADL) and/or instrumental activities of daily living (IADL), simplified to four items. Univariate and multivariate logistic models of disabled patients were performed. The three final multivariate models were compared using the area under the receiver operating characteristic curve (AUC/ROC) of the logistic model. Results The mean age was 80.6 years, and 51% of the patients were women with various types of cancer. The prevalence of disability was 67.6%. No oncologic factors (cancer site, cancer extension) were associated with disability. Impaired mobility, poor functional status, depressive mood, cognitive impairment and polypharmacy were independently associated with disability ( P < 0.05). The AUC/ROC of the final models was similar. Conclusion Disability was highly prevalent in older cancer outpatients before cancer treatment but was not associated with oncologic factors. Impaired mobility, depressed mood, cognitive impairment and polypharmacy were the geriatric variables significantly and independently associated with disability. Identifying these factors prior to cancer treatment could enable the implementation of corrective actions to improve patient autonomy before treatment and during follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
27. Access to information and counselling - older cancer patients' self-report: a crosssectional survey.
- Author
-
Guldhav, Kristin Vassbotn, Jepsen, Randi, Ytrehus, Siri, and Grov, Ellen Karine
- Subjects
- *
ANALYSIS of variance , *CANCER patients , *CHI-squared test , *CONFIDENCE intervals , *STATISTICAL correlation , *COUNSELING , *FISHER exact test , *HEALTH , *HOME nursing , *QUESTIONNAIRES , *RESEARCH funding , *SELF-evaluation , *STATISTICS , *SURVEYS , *T-test (Statistics) , *INFORMATION resources , *LOGISTIC regression analysis , *DATA analysis , *ACCESS to information , *CROSS-sectional method , *DATA analysis software , *PATIENTS' attitudes , *DESCRIPTIVE statistics , *INFERENTIAL statistics , *ODDS ratio - Abstract
Background: An increasingly older population, improved diagnostics and treatment increase the number of older cancer survivors, thus more than 60% of those affected by cancer are over the age of 65. Symptom relief and the prevention of functional impairment are important tasks for home care nursing, considering that patients can live a long time with their cancer disease and related side effects. The aim of this study was to investigate the extent to which cancer patients over the age of 65 reported access to information and counselling from home care nursing services, including those offered by the cancer coordinator. Methods: A cross-sectional survey was used. The survey consisted of 174 cancer patients from two regions in Norway living at home (101 women; 66-92 years). The questionnaire contained questions of various sequences including information and advices given and data on access to and use of home health care services. The questions focused on the extent to which home health care services provided the following: 1) information about the disease and treatment, 2) information about consequences and complications of the cancer disease, 3) nutritional advice and 4) advice on physical activity. Demographic, clinical and organizational variables were used. SPSS program version 22 was employed to perform descriptive and inferential statistics including correlation and logistic regression analysis. For ethical reasons, patients who were dying, delirious or with presence of cognitive impairment (any kind of dementia) were excluded. Results: The results showed that a majority (67-77%) of the respondents reported low levels of information and counselling offered. Low levels represents in this study medium, small and very small degree (Likert scale). Women, those above 85 years of age and patients with a gynecological or hematological cancer diagnosis experienced less access to information and counselling. Respondents facing availability of a cancer coordinator reported significantly higher access to information about the disease and treatment (p = 0.03), nutritional advice (p = 0.04) and advice on physical activity (p = 0.04) compared to those who only had contact with a home health care nurse or home health care assistant. Conclusions: The results indicated that the availability of a cancer coordinator facilitated personalized information and counselling for older cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
28. Different impact of definitions of sarcopenia in defining frailty status in a population of older women with early breast cancer
- Abstract
Sarcopenia is a geriatric syndrome characterized by losses of quantity and quality of skeletal muscle, which is associated with negative outcomes in older adults and in cancer patients. Different definitions of sarcopenia have been used, with quantitative data more frequently used in oncology, while functional measures have been advocated in the geriatric literature. Little is known about the correlation between frailty status as assessed by comprehensive geriatric assessment (CGA) and sarcopenia in cancer patients. We retrospectively analyzed data from 96 older women with early breast cancer who underwent CGAs and Dual X-ray Absorptiometry (DXA) scans for muscle mass assessment before cancer treatment at a single cancer center from 2016 to 2019 to explore the correlation between frailty status as assessed by CGA and sarcopenia using different definitions. Based on the results of the CGA, 35 patients (36.5%) were defined as frail. Using DXA Appendicular Skeletal Mass (ASM) or the Skeletal Muscle Index (SMI=ASM/heightˆ2), 41 patients were found to be sarcopenic (42.7%), with no significant difference in prevalence between frail and nonfrail subjects. Using the European Working Group on Sarcopenia in Older People (EWGSOP2) definition of sarcopenia (where both muscle function and mass are required), 58 patients were classified as “probably” sarcopenic; among these, 25 were sarcopenic and 17 “severely” sarcopenic. Only 13 patients satisfied both the requirements for being defined as sarcopenic and frail. Grade 3-4 treatment-related toxicities (according to Common Terminology Criteria for Adverse Events) were more common in sarcopenic and frail sarcopenic patients. Our data support the use of a definition of sarcopenia that includes both quantitative and functional data in order to identify frail patients who need tailored treatment.
- Published
- 2021
29. Implementation of uHear™ - an iOS-based application to screen for hearing loss - in older patients with cancer undergoing a comprehensive geriatric assessment.
- Author
-
Lycke, Michelle, Boterberg, Tom, Martens, Evi, Ketelaars, Lore, Pottel, Hans, Lambrecht, Antoon, Van Eygen, Koen, De Coster, Laurence, Dhooge, Ingeborg, Wildiers, Hans, and Debruyne, Philip R.
- Abstract
Objective Validation of uHear™ as a screening tool to detect hearing loss in older patients with cancer without a known diagnosis of presbycusis, as part of a Comprehensive Geriatric Assessment (CGA). Materials and Methods Patients (≥ 70 years) with a histologically confirmed diagnosis of cancer, were enrolled at the time of CGA screening. Patients were evaluated by uHear™, which was compared to conventional audiometry as gold standard. We defined a pure-tone average (PTA) of ≥ 40 dB HL as the pass or fail screening cut-off. Validation of uHear™ was defined in terms of diagnostic accuracy through Receiver Operating Characteristics (ROC)-analysis. To accept uHear™, we estimated that the Area Under the ROC-curve (AUC) had to differ significantly from 0.50 with an AUC of at least 0.70. The Whispered Voice Test and Hearing Handicap Inventory for the Elderly were also administered. Results Thirty-three patients consented for participation. In one patient, the results of one ear were excluded from the analysis as the patient was documented with a known hearing disorder in that ear. Significant hearing loss, defined by a PTA of ≥ 40 dB HL calculated from the air conduction thresholds at 0.5, 1.0 and 2.0 kHz, was found in 15.4% of tested ears. uHear™ showed excellent diagnostic accuracy with an AUC ± SE of 0.98 ± 0.14. It provided maximum sensitivity (100.0%) but poor specificity (36.4%) at our predefined cut-off score of ≥ 40 dB HL. Conclusion uHear™ can be implemented as a screening tool to detect hearing loss in older patients with cancer within a CGA. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
30. Improving the experience of older people with colorectal and breast cancer in patient-centred cancer care pathways using experience-based co-design
- Author
-
Elvira Derks, Marja Y. Veenstra, Inge Melchior, Esther Stoffers, Albine Moser, Kon-Siong G. Jie, and RS: CAPHRI - R6 - Promoting Health & Personalised Care
- Subjects
INVOLVEMENT ,Medicine (General) ,caregivers ,Quality management ,Colorectal cancer ,Psychological intervention ,Vulnerability ,Breast Neoplasms ,colorectal cancer ,experience‐based co‐design ,SERVICE ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,R5-920 ,breast cancer ,Nursing ,Multidisciplinary approach ,Patient-Centered Care ,medicine ,Humans ,030212 general & internal medicine ,QUALITY IMPROVEMENT ,Aged ,business.industry ,030503 health policy & services ,Public Health, Environmental and Occupational Health ,Cancer ,patient and public involvement ,medicine.disease ,POLICY ,EMERGENCY-DEPARTMENT ,Original Research Paper ,STAFF ,experience-based co-design ,Facilitator ,cancer care pathways ,Female ,Patient Participation ,Public aspects of medicine ,RA1-1270 ,0305 other medical science ,business ,Colorectal Neoplasms ,older cancer patients ,Original Research Papers - Abstract
Background Patient and public involvement (PPI) in quality improvement of oncological care pathways for older patients are rare. Objectives Improve the care pathway experience of older cancer patients and explore lessons learned regarding how to engage this vulnerable group. Design Experience-Based Co-Design. Setting and participants Older cancer patients, their caregivers and healthcare professionals within colorectal and breast cancer care pathways. Interventions Co-design quality improvement teams. Main outcome measures Colorectal cancer care pathway touchpoints were (a) availability of a contact person during diagnostic, treatment and aftercare phases; (b) collaboration between physicians and different hospital departments; (c) continuous relationship with same physician; (d) respectful treatment; (e) and information transfer with primary care. Breast cancer care pathway touchpoints were (a) comprehensive information package and information provision, (b) care planning based on patient preferences, (c) continuity of patient-professional relationship and (d) specialized care in case of vulnerability. Challenges related to PPI included (a) ability of older cancer patients to be reflective, critical and think at a collective level; (b) gaining support and commitment of professionals; (d) overcoming cultural differences and power inequalities; and (e) involving researchers and facilitators with appropriate expertise and position. Conclusion This multidisciplinary quality improvement project revealed several challenges of PPI with older cancer patients and their caregivers. Research teams themselves need to assume the role of facilitator to enable meaningful PPI of older cancer patients. Patient or public contribution Patient and caregiver representatives and advocates were involved in the design, conduct, analysis, interpretation of the data and preparation of this manuscript.
- Published
- 2021
31. Malnutrition in older patients with cancer: Appraisal of the Mini Nutritional Assessment, weight loss, and body mass index.
- Author
-
Zhang, Xiaotao, Sun, Ming, McKoy, June M., Bhulani, Nizar Noor Ali, Valero, Vicente, Barcenas, Carlos H., Popat, Uday R., Sri, Meghan Karuturi, Shah, Jay B., Dinney, Colin P., Hedberg, Ann-Marie, Champlin, Richard, Tripathy, Debu, Holmes, Holly M., Stroehlein, John R., and Edwards, Beatrice J.
- Published
- 2018
- Full Text
- View/download PDF
32. Development and psychometric validation of a brief comprehensive health status assessment scale in older patients with hematological malignancies: The GAH Scale.
- Author
-
Bonanad, S., De la Rubia, J., Gironella, M., Pérez Persona, E., González, B., Fernández Lago, C., Arnan, M., Zudaire, M., Hernández Rivas, J.A., Soler, A., Marrero, C., Olivier, C., Altés, A., Valcárcel, D., Hernández, M.T., Oiartzabal, I., Fernández Ordoño, R., Arnao, M., Esquerra, A., and Sarrá, J.
- Abstract
Objectives The purpose of this study was to develop a new brief, comprehensive geriatric assessment scale for older patients diagnosed with different hematological malignancies, the Geriatric Assessment in Hematology (GAH scale), and to determine its psychometric properties. Materials and Methods The 30-item GAH scale was designed through a multi-step process to cover 8 relevant dimensions. This is an observational study conducted in 363 patients aged ≥ 65 years, newly diagnosed with different hematological malignancies (myelodysplasic syndrome/acute myeloblastic leukemia, multiple myeloma, or chronic lymphocytic leukemia), and treatment-naïve. The scale psychometric validation process included the analyses of feasibility, floor and ceiling effect, validity and reliability criteria. Results Mean time taken to complete the GAH scale was 11.9 ± 4.7 min that improved through a learning-curve effect. Almost 90% of patients completed all items, and no floor or ceiling effects were identified. Criterion validity was supported by reasonable correlations between the GAH scale dimensions and three contrast variables (global health visual analogue scale, ECOG and Karnofsky), except for comorbidities. Factor analysis (supported by the scree plot) revealed nine factors that explained almost 60% of the total variance. Moderate internal consistency reliability was found (Cronbach's α: 0.610), and test–retest was excellent (ICC coefficients, 0.695–0.928). Conclusion Our study suggests that the GAH scale is a valid, internally reliable and a consistent tool to assess health status in older patients with different hematological malignancies. Future large studies should confirm whether the GAH scale may be a tool to improve clinical decision-making in older patients with hematological malignancies. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
33. A cohort study on the evolution of psychosocial problems in older patients with breast or colorectal cancer: comparison with younger cancer patients and older primary care patients without cancer.
- Author
-
Deckx, Laura, van Abbema, Doris L., van den Akker, Marjan, van den Broeke, Carine, van Driel, Mieke, Bulens, Paul, Tjan-Heijnen, Vivianne C. G., Kenis, Cindy, de Jonge, Eric T., Houben, Bert, and Buntinx, Frank
- Subjects
BREAST cancer patients ,COHORT analysis ,SOCIAL psychology ,OLDER patients ,COLON cancer patients ,PRIMARY care ,COMPARATIVE studies - Abstract
Background: Although older cancer survivors commonly report psychosocial problems, the impact of both cancer and ageing on the occurrence of these problems remains largely unknown. The evolution of depression, cognitive functioning, and fatigue was evaluated in a group of older cancer patients in comparison with a group of younger cancer patients and older persons without cancer. Methods: Older (=70 years) and younger cancer patients (50 - 69 years) with breast or colorectal cancer stage I - III, and older persons without cancer (=70 years) were included. Data were collected at baseline and one year follow-up and were available for 536 persons. Depression was evaluated with the 15-item Geriatric Depression Scale. Cognitive functioning was measured with the cognitive functioning subscale of the European Organization for Research and Treatment of Cancer. Fatigue was measured with a Visual Analogue Scale. Risk factors for depression, cognitive functioning, and fatigue were analysed using multivariate logistic regression analyses. Risk factors included cancer- and ageing-related factors such as functional status, cancer treatment, and comorbidities. Results: The evolution of psychosocial problems was similar for the group of older (N = 125) and younger cancer patients (N = 196): an increase in depression (p < 0.01), slight worsening in cognitive functioning (p = 0.01), and no clear change in fatigue. Also, compared to the group of people without cancer (N = 215), the differences were small and after one year of follow-up only depression was more frequent in older cancer patients compared to older persons without cancer (18 % versus 9 %, p = 0.04). In multivariate analyses the main risk factors for psychosocial problems after one year follow-up were changes in functional status and presence of baseline depression, fatigue, or cognitive impairment. Conclusion: Over the course of one year after a diagnosis of cancer, cancer patients face increasing levels of depression and increasing difficulties in cognitive functioning. The main risk factor for psychosocial problems was presence of the problem at baseline. This calls for regular screening for psychosocial problems and exchange of information on psychosocial functioning between different health care providers and settings during the treatment and follow-up trajectory of cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
34. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations†
- Author
-
Decoster, L., Van Puyvelde, K., Mohile, S., Wedding, U., Basso, U., Colloca, G., Rostoft, S., Overcash, J., Wildiers, H., Steer, C., Kimmick, G., Kanesvaran, R., Luciani, A., Terret, C., Hurria, A., Kenis, C., Audisio, R., and Extermann, M.
- Abstract
Background: Screening tools are proposed to identify those older cancer patients in need of geriatric assessment (GA) and multidisciplinary approach. We aimed to update the International Society of Geriatric Oncology (SIOG) 2005 recommendations on the use of screening tools. Materials and methods: SIOG composed a task group to review, interpret and discuss evidence on the use of screening tools in older cancer patients. A systematic review was carried out and discussed by an expert panel, leading to a consensus statement on their use. Results: Forty-four studies reporting on the use of 17 different screening tools in older cancer patients were identified. The tools most studied in older cancer patients are G8, Flemish version of the Triage Risk Screening Tool (fTRST) and Vulnerable Elders Survey-13 (VES-13). Across all studies, the highest sensitivity was observed for: G8, fTRST, Oncogeriatric screen, Study of Osteoporotic Fractures, Eastern Cooperative Oncology Group-Performance Status, Senior Adult Oncology Program (SAOP) 2 screening and Gerhematolim. In 11 direct comparisons for detecting problems on a full GA, the G8 was more or equally sensitive than other instruments in all six comparisons, whereas results were mixed for the VES-13 in seven comparisons. In addition, different tools have demonstrated associations with outcome measures, including G8 and VES-13. Conclusions: Screening tools do not replace GA but are recommended in a busy practice in order to identify those patients in need of full GA. If abnormal, screening should be followed by GA and guided multidisciplinary interventions. Several tools are available with different performance for various parameters (including sensitivity for addressing the need for further GA). Further research should focus on the ability of screening tools to build clinical pathways and to predict different outcome parameters. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
35. Depression, anxiety, and somatic symptoms in older cancer patients: a comparison across age groups.
- Author
-
Cohen, Miri
- Subjects
- *
DISEASES in older people , *CANCER patient psychology , *DEPRESSED persons , *AGE groups - Abstract
Background Previous studies have reported that older cancer patients experience lower psychological distress than younger patients, but most prior studies do not differentiate between age groups within the 'older' category. Aim The aim of this study was to assess the intensity of the symptoms of depression, anxiety, and somatic symptoms among different age groups of older cancer patients. Methods Participants were composed of 321 cancer patients 60 years and older, who were divided into three age groups: 60-69, 70-79, and 80+ years. The participants answered the Brief Symptom Inventory-18, which included subscales for depression, anxiety, and somatic symptoms and the cancer-related problem list, in addition to providing personal and cancer-related details. Results Depressive, anxiety, and somatic symptoms and cancer-related problems were lowest in the 70-79 years age group and highest in the 80+ years age group. Comparisons between pairs of groups showed significant differences between each of the groups in Brief Symptom Inventory total scores and between the 80+ years age group and the other two groups in regard to depressive symptoms and cancer-related problems. Differences, related to anxiety and somatic symptoms, were significant for the 70-79 year olds, in comparison with the youngest and oldest groups. Intensity of symptoms was explained by older age, higher number of cancer-related problems, female gender, and lower income. Conclusion Nonlinear relations exist between age and psychological symptoms, which is in line with the postponement of age-related health and functional decline in the modern era. These results suggest that the study of psychological reactions to cancer should examine differences between age groups among older cancer patients. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
36. Frailty indicators and functional status in older patients after colorectal cancer surgery.
- Author
-
Rønning, Benedicte, Wyller, Torgeir Bruun, Jordhøy, Marit Slaaen, Nesbakken, Arild, Bakka, Arne, Seljeflot, Ingebjørg, and Kristjansson, Siri Rostoft
- Abstract
Abstract: Objectives: The number of older survivors from colorectal cancer is increasing, but little is known regarding long-term consequences of cancer treatment in this patient group. Physical function is an important outcome for older patients, affecting both autonomy and quality of life. We aimed to investigate physical function in older patients with colorectal cancer before and after surgery, and to examine the role of individual frailty indicators as predictors of functional decline. Material and Methods: We present 16–28months follow-up data of older patients after elective surgery for colorectal cancer. During a home-visit, physical function was evaluated by activities of daily living (ADL), instrumental activities of daily living (IADL), the timed up-and-go (TUG) test, and grip strength. Measurements were compared with those obtained preoperatively using the Wilcoxon signed rank test. Frailty indicators were dichotomized and implemented in logistic regression models to explore their associations to a decline in the physical function scores. Results: Eighty-four patients were included and the median age was 82years. There was a significant decrease in ADL (p=0.04) and IADL scores (p≤0.001) at follow-up. We found no associations between frailty indicators and the risk of decline in physical functioning. Conclusion: In our population of older patients with surgically treated colorectal cancer, there was a significant decline in ADL- and IADL-scores at follow-up. No change was found in TUG or grip strength, and frailty indicators did not predict decline in physical function. [Copyright &y& Elsevier]
- Published
- 2014
- Full Text
- View/download PDF
37. The effect of treatment modifications by an onco-geriatric MDT on one-year mortality, days spent at home and postoperative complications
- Author
-
Geertruida H. de Bock, Suzanne Festen, Annya H D van der Leest, Barbara L. van Leeuwen, Pauline de Graeff, Anna K.L. Reyners, Hanneke van der Wal-Huisman, Targeted Gynaecologic Oncology (TARGON), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Life Course Epidemiology (LCE), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)
- Subjects
PREDICTOR ,medicine.medical_specialty ,SURGERY ,Colorectal cancer ,DECISION-MAKING ,Malignancy ,COLORECTAL-CANCER ,One year mortality ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,OUTCOME PRIORITIZATION ,Older patients ,Internal medicine ,Neoplasms ,medicine ,Humans ,030212 general & internal medicine ,ELDERLY-PATIENTS ,FRAILTY ,Geriatric Assessment ,Aged ,Retrospective Studies ,Days spent at home ,OLDER PATIENTS ,business.industry ,Patient preferences ,Retrospective cohort study ,Geriatric assessment ,ASSOCIATION ,Treatment decision-making ,University hospital ,medicine.disease ,Oncology ,030220 oncology & carcinogenesis ,SURVIVAL ,Female ,Treatment decision making ,Geriatrics and Gerontology ,business ,Older cancer patients - Abstract
Objectives: Decision-making in older patients with cancer can be complex, as benefits of treatment should be weighed against possible side-effects and life-expectancy. A novel care pathway was set up incorporating geriatric assessment into treatment decision-making for older cancer patients. Treatment decisions could be modified following discussion in an onco-geriatric multidisciplinary team (MDT). We assessed the effect of treatment modifications on outcomes. Materials and methods: This retrospective study was performed in the surgical department of a University Hospital. Patients of 70 years and older with a solid malignancy were included. All patients underwent a nurse-led geriatric assessment (GA) and were discussed in an onco-geriatric MDT. This could result in a modified or an unchanged treatment advice compared to the regular tumor board. Primary outcome was one-year mortality. Secondary outcomes were post-operative complications and days spent in hospital in the first year after inclusion. Results: For the 184 patients in the analyses, the median age was 77.5 years and 41.8% were female. For 46 patients (25%), the treatment advice was modified by the onco-geriatric MDT. There was no significant difference in one-year mortality between the unchanged and modified group (29.7% versus 26.1%, p = 0.7). There were, however, significantly fewer days spent in hospital (median 5 vs 8.5 days p = 0.02) and fewer grade II or higher postoperative complications (13.3% versus 35.5% p = 0.005) in the modified group. Conclusion: Incorporating geriatric assessment in decision-making did not lead to excess one-year mortality, but did result in fewer complications and days spent in hospital. (c) 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
- Published
- 2020
38. CT Derived Muscle Measures, Inflammation, and Frailty in a Cohort of Older Cancer Patients
- Author
-
Jurate Saltyte Benth, Marit Slaaen, Sverre Bergh, Siri Rostoft, Bjørn Henning Grønberg, Magnus Harneshaug, and Lene Kirkhus
- Subjects
Cancer Research ,medicine.medical_specialty ,Frail Elderly ,Inflammation ,frailty ,Muscle mass ,General Biochemistry, Genetics and Molecular Biology ,Prognostic score ,Older patients ,Internal medicine ,Neoplasms ,medicine ,Humans ,Aged ,muscle loss ,Pharmacology ,Third lumbar vertebra ,Muscle loss ,Frailty ,business.industry ,Muscles ,Cancer ,medicine.disease ,Cohort ,medicine.symptom ,older cancer patients ,business ,Tomography, X-Ray Computed ,Biomarkers ,Research Article - Abstract
Background/Aim: Muscle loss, inflammation, and frailty are prevalent among older cancer patients. We aimed to evaluate whether inflammatory markers could identify muscle loss, and if muscle measures differed between frail and non-frail patients. Patients and Methods: A total of 115 patients ≥70 years old with solid tumors were included. Inflammation was measured using the Glasgow Prognostic Score (GPS), which is based on C-reactive protein (CRP) and albumin levels, and CRP alone. Frailty was evaluated using a modified geriatric assessment (mGA) of eight domains affecting older patients' health status. Computed tomography-derived muscle measures were collected at the level of the third lumbar vertebra. Results: Patients with GPS=2 and CRP>27 mg/l exhibited poorer muscle measures compared to patients with lower levels. No associations between mGA-based frailty and muscle mass were found. Conclusion: Inflammation has detrimental effects on muscle mass. However, GPS or CRP alone cannot be used to identify muscle loss, and muscle measures were not associated with frailty in this series. DOI: doi:10.21873/invivo.12200. This article is freely accessible online. Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
- Published
- 2020
39. (Index B12XCRP) et impact sur le devenir des patients âgés de plus de 70 ans atteints de cancer et pris en charge en ambulatoire dans un hôpital de jour d'oncogériatrie
- Author
-
Puchades, Eddy, Aix-Marseille Université - École de médecine (AMU SMPM MED), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), and Anne-Laure Couderc
- Subjects
C-Reactive Protein ,Protéine C réactive ,Survie ,High serum vitamin B12 levels ,Early hospitalization ,Patients âgés ,[SDV]Life Sciences [q-bio] ,Hypervitaminémie B12 ,Ré-hospitalisation précoce ,Early death ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Older cancer patients ,Cancer - Abstract
Thèse présentée sous la forme d'une "Thèse Article"; For a long time, older cancer patients have been treated according to their physiological age regardless of their state of health. A pretreatment Comprehensive Geriatric Assessment (CGA) has been proposed to assess prognosis and to adapt oncological care. However, few biological markers are incorporated in the medical decision. Our monocentric, retrospective, comparative study on 621 older cancer patients with a median age of 81 years (range 70 to 98 years) highlighted high serum vitamin B12 levels (HCbl) and the serum vitamin B12-CRP index (BCI) as prognostic factors of early death and early hospitalization.According to the multivariate analysis, HCbl is a prognostic factor of mortality within 3 months (OR 5.59; 95% CI; [1.94-15.94], p = 0.001) and 12 months (OR 5.16; 95% CI; [2.19-12.18], p = 0.0001). BCI is a prognostic factor of mortality (OR 4.43; 95% CI; [1.22-15.02], p = 0.02) and unexpected hospitalization within 3 months (OR 4.2; 95% CI; [1.7-10.28], p = 0.001).Other factors such as a Body Mass Index of 18 to 21 kg/m2 (OR 2.92; 95% CI; [1-8.08], p = 0.04), mobility with gait speed (OR 3.59; 95% CI; [1.42-9.43], p = 0.007) or palliative treatment (OR 13.66; 95% CI; [3.96-46.43], p < 0.0001) have a pejorative impact on 3-month mortality. In the same way, timed up and go test (OR 3.66; 95% CI; [1.83-7.41], p = 0.0002)) and palliative treatment (OR 5.07; 95% CI; [1.81-14.21], p = 0.002) have an impact on 12-month mortality. Regarding early hospitalizations, the metastatic status (OR 2.07; 95% CI; [1.02-4.22], p = 0.04) and performance status (PS) (OR 2.18; 95% CI; [1.05-4.5], p = 0.03) are prognostic factors during the first month; activities of daily living (ADL) (OR 1.85; 95% CI; [1.05-4.39], p = 0.03) is a prognostic factor during the first 3 months of treatment.In patients aged over 70 years with cancer, HCbl, BCI, BMI, mobility, and palliative treatment predicted early death. BCI, metastatic status, and PS predicted early hospitalization during the first month, and BCI and ADL during the first 3 months. We recommend determining serum vitamin B12 levels and BCI routinely as part of a pretreatment workup in older cancer patients in order to access more precisely the early hospitalization and death risk profile.; Les personnes âgées atteintes de cancer ont pendant longtemps été traitées uniquement en fonction de leur âge sans tenir compte de leur état de santé. Le développement des Évaluations Gériatriques Standardisées (EGS) avant les traitements oncologiques a permis d’adapter la prise en charge aux fragilités des patients âgés. Or, peu de marqueurs biologiques sont intégrés à la décision thérapeutique. Notre étude monocentrique, rétrospective et comparative sur 621 patients âgés atteints de cancer de médiane d’âge 81 ans (extrêmes de 78 à 98 ans), a porté l’hypervitaminémie B12 (hyper-B12) et le BCI (produit de la vitamine B12 et de la protéine C réactive) comme marqueurs biologiques pronostiques de mortalité et de ré-hospitalisation non programmée dans cette population. En analyse multivariée, l’hyper-B12 est un facteur pronostic associé à une moins bonne survie à 3 mois (OR 5.59 ; IC95% ; [1.94-15.94], p=0.001) et 12 mois (OR 5.16 ; IC95% ; [2.19-12.18], p=0.0001) mais le BCI est facteur pronostique de survie et de ré-hospitalisation non-programmée à 3 mois (OR 4.43 ; IC95%; [1.22-15.02], p=0.02 ; OR 4.2 ; IC95% ; [1.7-10.28], p=0.001 respectivement). Dans notre étude, d’autres facteurs influencent la mortalité comme l’indice de masse corporelle entre 18 et 21 (OR 2.92 ; IC95% ; [1-8.08], p= 0.04) et le traitement palliatif (OR 13.66; 95% CI; [3.96-46.43], p < 0.0001) à 3 mois ; le timed up and go test (OR 3.66 ; IC95% ; [1.83-7.41], p = 0.0002)) et le traitement palliatif (OR 5.07 ; IC95% ; [1.81-14.21], p=0.002) à 12 mois. Concernant les hospitalisations précoces lors du premier mois de prise en charge, le statut métastatique de la tumeur (OR 2.07 ; IC95% ; [1.02-4.22], p=0.04) et le performance status (PS) (OR 2.18 ; IC95% ; [1.05-4.5], p=0.03) sont des facteurs; et dans les 3 mois de prise en charge, l’autonomie avec l’ADL (OR 1.85 ;IC95% ; [1.05-4.39], p=0.03) est un facteur de ré-hospitalisation.En conclusion, chez les patients âgés de 70 ans et plus atteints de cancer, l’hypervitaminémie B12, le BCI, l’IMC, la mobilité et le traitement palliatif entrepris sont des facteurs de mortalité précoce. Le BCI, le PS et le stade métastatique de la tumeur sont des facteurs de ré-hospitalisation précoce à 1 mois ; le BCI et l’ADL sont des facteurs de ré-hospitalisation précoce à 3 mois. Nous recommandons de réaliser le taux de vitamine B12 et le calcul du BCI dans la prise en charge initiale des patients âgés atteints de cancer et notamment en médecine de ville.
- Published
- 2019
40. The SAKK cancer-specific geriatric assessment (C-SGA): a pilot study of a brief tool for clinical decision-making in older cancer patients.
- Author
-
Clough-Gorr, Kerri M., Noti, Lea, Brauchli, Peter, Cathomas, Richard, Fried, Marius R., Roberts, Gillian, Stuck, Andreas E., Hitz, Felicitas, and Mey, Ulrich
- Subjects
- *
CANCER patients , *GERIATRIC oncology , *MEDICAL decision making , *CANCER chemotherapy , *MEDICAL needs assessment - Abstract
Background: Recommendations from international task forces on geriatric assessment emphasize the need for research including validation of cancer-specific geriatric assessment (C-SGA) tools in oncological settings. This study was to evaluate the feasibility of the SAKK Cancer-Specific Geriatric Assessment (C-SGA) in clinical practice. Methods: A cross sectional study of cancer patients ⩾65 years old (N = 51) with pathologically confirmed cancer presenting for initiation of chemotherapy treatment (07/01/2009-03/31/2011) at two oncology departments in Swiss canton hospitals: Kantonsspital Graubünden (KSGR N = 25), Kantonsspital St. Gallen (KSSG N = 26). Data was collected using three instruments, the SAKK C-SGA plus physician and patient evaluation forms. The SAKK C-SGA includes six measures covering five geriatric assessment domains (comorbidity, function, psychosocial, nutrition, cognition) using a mix of medical record abstraction (MRA) and patient interview. Five individual domains and one overall SAKK C-SGA score were calculated and dichotomized as below/above literature-based cut-offs. The SAKK C-SGA was evaluated by: patient and physician estimated time to complete, ease of completing, and difficult or unanswered questions. Results: Time to complete the patient questionnaire was considered acceptable by almost all (⩾96%) patients and physicians. Patients reported slightly shorter times to complete the questionnaire than physicians (17.33 ± 7.34 vs. 20.59 ± 6.53 minutes, p = 0.02). Both groups rated the patient questionnaire as easy/fairly easy to complete (91% vs. 84% respectively, p = 0.14) with few difficult or unanswered questions. The MRA took on average 8.32 ± 4.72 minutes to complete. Physicians (100%) considered time to complete MRA acceptable, 96% rated it as easy/fairly easy to complete. Individual study site populations differed on health-related characteristics (excellent/good physician-rated general health KSGR 71% vs. KSSG 32%, p = 0.007). The overall mean C-SGA score was 2.4 ± 1.12. Patients at KSGR had lower C-SGA scores (2.00 ± 1.19 vs. 2.81 ± 0.90, p = 0.009) and a smaller proportion (28% vs.65%, p = 0.008) was above the C-SGA cut-off score compared to KSSG. Conclusions: These results suggest the SAKK C-SGA is a feasible practical tool for use in clinical practice. It demonstrated discriminative ability based on objective geriatric assessment measures, but additional investigations on use for clinical decision-making are warranted. The SAKK C-SGA also provides important usable domain information for intervention to optimize outcomes in older cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
41. Age-specific incidence ratios of colorectal cancer (CRC) in Turkey: CRC in older people is increasing
- Author
-
Tas, Faruk and Keskin, Serkan
- Subjects
- *
AGE distribution , *COLON tumors , *PROBABILITY theory , *DESCRIPTIVE statistics , *DIAGNOSIS ,RECTUM tumors - Abstract
Abstract: Life expectancy has greatly increased in the last century. In the last decades, cancer in the older people has become an increasingly common problem owing to the prolonged life-expectancy of the general population and to the improved management of common cancers. The aim of this study was to demonstrate the age-specific incidence ratios in patients with CRC. Data were collected from hospital-based registries from 1988 to 2007. A total of 4209 patients were assessed. The median age at diagnosis was 58 years. When compared to Surveillance Epidemiology and End Results (SEER) data, these values were found to be 13 years younger than American patients. Trends consist of the median ages of patients were increased during years (p <0.001). Along the years, especially in the last years, the ratios of cancer patients of older than 70 years were significantly increased among the cancer patient populations. CRC in older person has become an increasingly common problem in the last years. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
42. Effects of communication skills training and a Question Prompt Sheet to improve communication with older cancer patients: A randomized controlled trial
- Author
-
van Weert, Julia C.M., Jansen, Jesse, Spreeuwenberg, Peter M.M., van Dulmen, Sandra, and Bensing, Jozien M.
- Subjects
- *
OLDER patients , *RANDOMIZED controlled trials , *CANCER chemotherapy , *CANCER patients , *MEDICAL communication , *PATIENT education , *VIDEO recording - Abstract
Abstract: A randomized pre- and post-test control group design was conducted in 12 oncology wards to investigate the effectiveness of an intervention, existing of a communication skills training with web-enabled video feedback and a Question Prompt Sheet (QPS), which aimed to improve patient education to older cancer patients (≥65 years). The effects were studied by analyzing questionnaires and video recordings of patient education sessions preceding chemotherapy with 210 different patients. Patients’ recall of information was the primary outcome of the study. Recall was checked against the actual communication in the video-recordings. Moreover, communication skills were assessed by observing the extent to which nurses implemented 67 communication aspects, categorized in seven dimensions, using the QUOTEchemo. Experimental nurses demonstrated a significant intervention effect on communicating realistic expectations. Within-group improvements were measured in the experimental group for tailored communication, affective communication and interpersonal communication. Although the use of a QPS significantly increased question asking, only limited results were found on older patients’ recall scores. The overall proportion recall of recommendations showed a marginally significant pre-/post-change in proportion recall in favour of the experimental group and there was a significant pre-/post-change in two out of six sub-categories. The results indicate that nurses’ communication skills can be improved by communication skills training. More research is needed to understand the difficult relationship between patient–provider communication and recall of information. [Copyright &y& Elsevier]
- Published
- 2011
- Full Text
- View/download PDF
43. Development of a cancer-specific Comprehensive Geriatric Assessment in a University Hospital in Spain
- Author
-
Molina-Garrido, M.J. and Guillén-Ponce, C.
- Subjects
- *
GERIATRIC nursing , *UNIVERSITY hospitals , *CANCER patients , *PERIODIC health examinations , *MALNUTRITION - Abstract
Abstract: Introduction: The Comprehensive Geriatric Assessment (CGA) is a key component of the treatment approach for older cancer patients. The goals of the current study were to develop a brief but non-self-administered cancer-specific geriatric assessment and to determine its feasibility, as measured by (1) the length of time to completion and (2) patient satisfaction. Methods: The literature was reviewed to select validated scales for geriatric assessment across the following domains: functional status, co-morbidity, cognition, social support and risk of malnutrition. Oncologic patients older than 70 years were included in the study. Results: The instrument was completed by 99 patients (mean age, 78.65 yrs). The mean time to completion of that was 12.9min (range, 9.5–20.5min). Most patients were satisfied with its length (63.6%), and most considered it fairly easy to complete (69.7%). Conclusions: The designed CGA was accepted by most patients and was not perceived to be overly time-consuming. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
44. Short-term monitoring of cognitive functions before and during the first course of treatment.
- Author
-
Eberhardt, Barbara, Dilger, Stefan, Musial, Frauke, Wedding, Ulrich, Weiss, Thomas, and Miltner, Wolfgang
- Subjects
- *
CANCER education , *DRUG side effects , *DRUG therapy , *HEMATOLOGICAL oncology , *COGNITIVE ability , *VERBAL learning , *INTESTINAL cancer , *AGE factors in memory , *RESEARCH - Abstract
Purpose: Side effects of chemotherapy on cognitive functions in older patients have rarely been investigated. Addressing this lack of research, the present study evaluated cognitive functions in older cancer patients. Methods: A total of 130 younger ( n=59; age<60) and older ( n=71; age≥60) cancer patients with hematological disease or cancer of the intestinal tract took part in the study. To explore short-term effects of chemotherapy, a group of patients assessed before the start of chemotherapy was compared with patients who already received their first course of chemotherapy. Results: Cognitive impairments of verbal learning, word fluency, and memory were observed following the first few days after treatment onset. Older patients showed stronger memory impairments after start of chemotherapy than younger cancer patients. Additionally, depression was neither associated with short-term effect of chemotherapy nor with age. Conclusions: The results suggest that chemotherapy has negative short-term effects on some cognitive functions. But age-dependent effects were only found for memory. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
45. Elements of How Older Patients with Metastatic Cancer Come to 'Nattoku' with Treatment
- Subjects
治療過程 ,転移 ,納得 ,metastasis ,treatment process ,older cancer patients ,高齢がん患者 ,coming to “nattoku” - Abstract
本研究の目的は,転移のある高齢がん患者の治療に対する納得の要素を明らかにすることである.本研究では,納得とは「高齢がん患者が治療に対して,能動的に認知的かつ感情的に受容した状態」と定義する.研究方法は質的記述的研究デザインで、がんに対して治療を選択した現在治療過程にある65 歳以上の転移のある高齢がん患者20名を対象に半構造化面接法を実施した.結果,転移のある高齢がん患者の治療に対する納得の要素として,【自分を救おうとする強い意志】【生きるための治療であるとの確信】【治療の可能性への期待】【信じて任せられる最善の治療であるとの判断】【周りへ報いたいとの希求】【治療を含めて生ききる人生の受け容れ】の6つのカテゴリーが抽出された.これらの転移のある高齢がん患者の治療に対する納得の要素の特徴として,1 つは患者自身の価値が治療状況に反映していることが示唆された.2つ目として,自己の利害にとらわれずに周りの人達の気持ちを察し,それを自分の気持ちや意志として汲み取る特徴が推察できた.3つ目として,治療だけでなく,自分の人生に対するあり方や生き方も含めた今の状況に対する受け容れでもある特徴が示唆された.それは,病期が進んだ状況でのライフサイクル最終段階にある高齢者のもつ特徴が表れていた.また,これらの要素は転移のある高齢がん患者が生きてきた中で培われたものでもあり,その人の生き様や今の状況に患者がコミットできるように支援することも納得に導いていく看護となることが示唆された., The objective of this study was to identify elements of how older patients with metastatic cancer become “nattoku” with treatment. In this study, nattoku was defined as “a state of cognitive and emotional acceptance of treatment” by older cancer patients. A qualitative descriptive study was employed, and semi-structured interviews were carried out with 20 metastatic cancer patients aged 65 years or older who were currently undergoing cancer treatment on their own volition. We extracted six elements that involve becoming nattoku with treatment: a strong intention to save oneself, certainty that the treatment was required in order to live, expectations of the potential of treatment, trusting that they chose the optimum treatment, the desire to give something back to those around them, and accepting to live life to the fullest, even while undergoing treatment. Our results suggested that the values of patients themselves were affected by their treatment status. Also, patients were not solely concerned with their own interests, but sensed the feelings of those around them and took them into consideration. A third characteristic suggested by our findings was their acceptance of treatment, and their attitude towards life and the way in which they have lived. This was characteristic of older patients with advanced illness who were in the final stage of life. These elements were fostered during the lives of older patients with metastatic cancer, and our study suggested that support that encourages patients to commit to a lifestyle and their current circumstances may help them become nattoku with treatment.
- Published
- 2016
46. Different Impact of Definitions of Sarcopenia in Defining Frailty Status in a Population of Older Women with Early Breast Cancer
- Author
-
Luca Tagliaferri, Beatrice Di Capua, Andrea Bellieni, Domenico Fusco, Riccardo Masetti, Roberto Bernabei, Giuseppe Colloca, Alejandro Martin Sanchez, Enrico Di Stasio, Gianluca Franceschini, Fabio Marazzi, and Elena Allocca
- Subjects
Gerontology ,Settore MED/18 - CHIRURGIA GENERALE ,Population ,lcsh:Medicine ,Medicine (miscellaneous) ,frailty ,Muscle mass ,Article ,sarcopenia ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,education ,Early breast cancer ,education.field_of_study ,business.industry ,lcsh:R ,Significant difference ,Cancer ,Common Terminology Criteria for Adverse Events ,physical performance ,musculoskeletal system ,Tailored treatment ,medicine.disease ,030220 oncology & carcinogenesis ,Sarcopenia ,older cancer patients ,business ,human activities - Abstract
Sarcopenia is a geriatric syndrome characterized by losses of quantity and quality of skeletal muscle, which is associated with negative outcomes in older adults and in cancer patients. Different definitions of sarcopenia have been used, with quantitative data more frequently used in oncology, while functional measures have been advocated in the geriatric literature. Little is known about the correlation between frailty status as assessed by comprehensive geriatric assessment (CGA) and sarcopenia in cancer patients. We retrospectively analyzed data from 96 older women with early breast cancer who underwent CGAs and Dual X-ray Absorptiometry (DXA) scans for muscle mass assessment before cancer treatment at a single cancer center from 2016 to 2019 to explore the correlation between frailty status as assessed by CGA and sarcopenia using different definitions. Based on the results of the CGA, 35 patients (36.5%) were defined as frail. Using DXA Appendicular Skeletal Mass (ASM) or the Skeletal Muscle Index (SMI=ASM/height^2), 41 patients were found to be sarcopenic (42.7%), with no significant difference in prevalence between frail and nonfrail subjects. Using the European Working Group on Sarcopenia in Older People (EWGSOP2) definition of sarcopenia (where both muscle function and mass are required), 58 patients were classified as “probably” sarcopenic, among these, 25 were sarcopenic and 17 “severely” sarcopenic. Only 13 patients satisfied both the requirements for being defined as sarcopenic and frail. Grade 3-4 treatment-related toxicities (according to Common Terminology Criteria for Adverse Events) were more common in sarcopenic and frail sarcopenic patients. Our data support the use of a definition of sarcopenia that includes both quantitative and functional data in order to identify frail patients who need tailored treatment.
- Published
- 2021
47. Different Impact of Definitions of Sarcopenia in Defining Frailty Status in a Population of Older Women with Early Breast Cancer.
- Author
-
Bellieni, Andrea, Fusco, Domenico, Sanchez, Alejandro Martin, Franceschini, Gianluca, Di Capua, Beatrice, Allocca, Elena, Di Stasio, Enrico, Marazzi, Fabio, Tagliaferri, Luca, Masetti, Riccardo, Bernabei, Roberto, and Colloca, Giuseppe Ferdinando
- Subjects
- *
MUSCLE mass , *OLDER women , *BREAST cancer , *SARCOPENIA , *DUAL-energy X-ray absorptiometry , *OLDER people , *AXILLA - Abstract
Sarcopenia is a geriatric syndrome characterized by losses of quantity and quality of skeletal muscle, which is associated with negative outcomes in older adults and in cancer patients. Different definitions of sarcopenia have been used, with quantitative data more frequently used in oncology, while functional measures have been advocated in the geriatric literature. Little is known about the correlation between frailty status as assessed by comprehensive geriatric assessment (CGA) and sarcopenia in cancer patients. We retrospectively analyzed data from 96 older women with early breast cancer who underwent CGAs and Dual X-ray Absorptiometry (DXA) scans for muscle mass assessment before cancer treatment at a single cancer center from 2016 to 2019 to explore the correlation between frailty status as assessed by CGA and sarcopenia using different definitions. Based on the results of the CGA, 35 patients (36.5%) were defined as frail. Using DXA Appendicular Skeletal Mass (ASM) or the Skeletal Muscle Index (SMI=ASM/height^2), 41 patients were found to be sarcopenic (42.7%), with no significant difference in prevalence between frail and nonfrail subjects. Using the European Working Group on Sarcopenia in Older People (EWGSOP2) definition of sarcopenia (where both muscle function and mass are required), 58 patients were classified as "probably" sarcopenic; among these, 25 were sarcopenic and 17 "severely" sarcopenic. Only 13 patients satisfied both the requirements for being defined as sarcopenic and frail. Grade 3-4 treatment-related toxicities (according to Common Terminology Criteria for Adverse Events) were more common in sarcopenic and frail sarcopenic patients. Our data support the use of a definition of sarcopenia that includes both quantitative and functional data in order to identify frail patients who need tailored treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
48. The effect of adjuvant chemotherapy on symptom burden and quality of life over time; a preliminary prospective observational study using individual data of patients aged ≥ 70 with early stage invasive breast cancer
- Abstract
Objectives: We aim to assess short and long term effects of chemotherapy on patient-reported quality of life (QOL) and patient versus clinician symptom reporting in older patients with breast cancer adjusted for tumour and aging parameters. Material and Methods: In this prospective, multicentre, non-interventional, observational study, women aged ≥ 70 years were enrolled after surgery and assigned to a TC chemotherapy (docetaxel and cyclophosphamide) group or a control group depending on their planned adjuvant treatment. Longitudinal multivariate models were used to assess the statistical and minimal clinically important difference (MCID) in the impact of TC chemotherapy over time on QOL and symptom burden adjusted for baseline aging and tumour parameters. Statistical significance was set at 5% and MCID at 10 points. Results: In total, 57 patients were enrolled in the chemotherapy and 52 patients in the control group. Within the chemotherapy group, clinical deterioration was reported at 3 months for Fatigue (17.73), Dyspnoea (17.05), Diarrhoea (12.06) and Appetite Loss (17.05) scores (all p < 0.001). However, the scores had returned to baseline (or even better for Role Functioning) at year 1. No clinical deterioration was reported in the control group. Symptom scores as reported by patients were significantly (p < 0.05) higher than those reported by the clinicians, even more so for Fatigue, Dyspnoea, and Pain. Conclusion: Our results show that symptom burden and diminished QOL in an older breast cancer population receiving adjuvant TC chemotherapy are short-lived and disappear after a while with no long-term differences compared to a similar population not receiving chemotherapy., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2018
49. 'Non-palliative care' – a qualitative study of older cancer patients’ and their family members’ experiences with the health care system
- Author
-
Grethe Eilertsen, Ellen Karine Grov, Marit Kirkevold, and Marianne Fjose
- Subjects
Adult ,Male ,medicine.medical_specialty ,Palliative care ,Family caregivers ,Health informatics ,Health administration ,Interviews as Topic ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Health care ,Humans ,Medicine ,030212 general & internal medicine ,Child ,Qualitative Research ,Aged ,Cancer ,Aged, 80 and over ,business.industry ,Health Policy ,Public health ,Nursing research ,lcsh:Public aspects of medicine ,lcsh:RA1-1270 ,Middle Aged ,Health services ,Older ,Caregivers ,Patient Satisfaction ,Spouse ,030220 oncology & carcinogenesis ,Family medicine ,VDP::Medisinske Fag: 700::Helsefag: 800::Sykepleievitenskap: 808 ,Female ,Family research ,business ,Delivery of Health Care ,Research Article ,Older cancer patients - Abstract
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Background: Among all cancer patients in the palliative phase, ¾ have reached the age of 65. An aging population will increase the number of people afflicted with cancer, and create challenges for patients, family members and health services. Nevertheless, limited research has focused explicitly on the experiences and needs of older cancer patients in the palliative phase and their families. Therefore, the aim of this study is to explore what older home dwelling cancer patients in the palliative phase and their close family members, as individuals and as a family, experience as important and difficult when facing the health services. Methods: We used a qualitative descriptive design. Data was collected through family group interviews with 26 families. Each interview consisted of an older home dwelling cancer patient and one to four family members with different relationships to the patient (e.g. spouse, adult children and/or children-in-law). Data was analysed by qualitative content analysis. Results: The main theme is “Non-palliative care” – health care services in the palliative phase not tailored to family needs. Three themes are revealed: 1) exhausting cancer follow-up, 2) a cry for family involvement, and 3) fragmented care. Conclusion: The health services seem poorly organised for meeting the demands of palliative care for older home dwelling cancer patients in the palliative phase and their family members. Close family members would like to contribute but health services lack systems for involving them in the follow-up of the patient. This project was funded by a research career grant to Marianne Fjose (Grant No. 2010/754–5806/2010), Western Norway University of Applied Sciences, Faculty of Health and Social Sciences, Department of Health and Caring Sciences, Førde, Norway, previously Sogn and Fjordane University College, Faculty of Health Studies, Førde, Norway.
- Published
- 2018
50. The effect of adjuvant chemotherapy on symptom burden and quality of life over time; a preliminary prospective observational study using individual data of patients aged ≥70 with early stage invasive breast cancer.
- Abstract
We aim to assess short and long term effects of chemotherapy on patient-reported quality of life (QOL) and patient versus clinician symptom reporting in older patients with breast cancer adjusted for tumour and aging parameters. In this prospective, multicentre, non-interventional, observational study, women aged ≥70years were enrolled after surgery and assigned to a TC chemotherapy (docetaxel and cyclophosphamide) group or a control group depending on their planned adjuvant treatment. Longitudinal multivariate models were used to assess the statistical and minimal clinically important difference (MCID) in the impact of TC chemotherapy over time on QOL and symptom burden adjusted for baseline aging and tumour parameters. Statistical significance was set at 5% and MCID at 10 points. In total, 57 patients were enrolled in the chemotherapy and 52 patients in the control group. Within the chemotherapy group, clinical deterioration was reported at 3months for Fatigue (17.73), Dyspnoea (17.05), Diarrhoea (12.06) and Appetite Loss (17.05) scores (all p<0.001). However, the scores had returned to baseline (or even better for Role Functioning) at year 1. No clinical deterioration was reported in the control group. Symptom scores as reported by patients were significantly (p<0.05) higher than those reported by the clinicians, even more so for Fatigue, Dyspnoea, and Pain. Our results show that symptom burden and diminished QOL in an older breast cancer population receiving adjuvant TC chemotherapy are short-lived and disappear after a while with no long-term differences compared to a similar population not receiving chemotherapy.
- Published
- 2017
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.