23 results on '"Olesen AW"'
Search Results
2. Developmental milestones in children born post-term in the Danish National Birth Cohort: a main research article.
- Author
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Olesen, AW, Olsen, J, and Zhu, JL
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ODDS ratio , *GESTATIONAL age , *COHORT analysis , *DURATION of pregnancy , *LOGISTIC regression analysis - Abstract
Objective To examine the timing of reaching developmental milestones in children born post-term. Design Cohort study. Setting The Danish National Birth Cohort: children born between 1997 and 2003. Population Data were obtained from a cohort of 92 892 pregnancies participating in the first pregnancy interview. All singletons born in gestational weeks 39-45 were identified. The study was then restricted to children who participated in an interview at the age of approximately 18 months and had information on at least one developmental milestone. We excluded children of mothers with chronic diseases from the final analysis. The remaining study population constituted of 43 915 singletons (27 503 born at term; 16 412 born post-term). Methods Logistic regression was used to calculate odds ratios of late achievement of these developmental milestones, adjusted for potential confounding factors. Main outcome measures Achieving developmental milestones at the time of interview or at a certain age. Results More children born post-term achieved the assessed developmental milestones compared with children born at term (39-40 weeks). A test for trend for gestational ages 39, 40, and 41 weeks also showed a positive trend at achieving developmental milestones with gestational age at birth in nine out of 14 milestone items. Conclusions Children born post-term appear to reach the main developmental milestones at an earlier age than children born at term. The association could also result from bias related to a longer time between conception and interviewing, misclassification of end points, or selection bias. [ABSTRACT FROM AUTHOR] more...
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- 2015
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3. The Danish National Birth Cohort -- its background, structure and aim.
- Author
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Olsen J, Melbye M, Olsen SF, Sørensen TIA, Aaby P, Andersen AN, Taxbøl D, Hansen KD, Juhl M, Schow TB, Sørensen HT, Andresen J, Mortensen EL, Olesen AW, and Søndergaard C
- Abstract
BACKGROUND: It is well known that the time from conception to early childhood has importance for health conditions that reach into later stages of life. Recent research supports this view, and diseases such as cardiovascular morbidity, cancer, mental illnesses, asthma, and allergy may all have component causes that act early in life. Exposures in this period, which influence fetal growth, cell divisions, and organ functioning, may have long-lasting impact on health and disease susceptibility. METHODS: To investigate these issues the Danish National Birth Cohort (Better health for mother and child) was established. A large cohort of pregnant women with long-term follow-up of the offspring was the obvious choice because many of the exposures of interest cannot be reconstructed with sufficient validity back in time. The study needs to be large, and it is aimed to recruit 100,000 women early in pregnancy, and to continue follow-up for decades. The Nordic countries are better suited for this kind of research than most other countries because of their population-based registers on diseases, demography and social conditions, linkable at the individual level by means of the unique ID-number given to all citizens. Exposure information is mainly collected by computer-assisted telephone interviews with the women twice during pregnancy and when their children are six and 18 months old. Participants are also asked to fill in a self-administered food frequency questionnaire in mid-pregnancy. Furthermore, a biological bank has been set up with blood taken from the mother twice during pregnancy and blood from the umbilical cord taken shortly after birth. Data collection started in 1996 and the project covered all regions in Denmark in 1999. By August 2000. a total of 60,000 pregnant women had been recruited to the study. It is expected that a large number of gene-environmental hypotheses need to be based on case-control analyses within a cohort like this. [ABSTRACT FROM AUTHOR] more...
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- 2001
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4. Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow-up six months after birth.
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Hjort-Pedersen K, Olesen AW, Garne E, and Sperling L
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- Pregnancy, Female, Humans, Follow-Up Studies, Cohort Studies, Denmark epidemiology, Ultrasonography, Prenatal, Fetus
- Abstract
Introduction: To investigate the performance of the second-trimester ultrasound scan regarding ultrasound-detectable congenital malformations in a Danish region. The study sample was population-based, with 6 months of postnatal follow-up. Hospital records and autopsy reports were reviewed in each case to validate the prenatal ultrasound diagnosis., Material and Methods: This population-based cohort study included all fetuses (n = 19.367) alive at the second-trimester scan in four hospitals in a Danish region. The final diagnosis of the malformations was based on hospital records during the 6-month postnatal follow-up. In case of termination or stillbirth, the result from the autopsy report was used to validate the prenatal ultrasound diagnosis., Results: The detection rate of congenital malformations in the prenatal screening program was 69%, where 18% was detected on the first-trimester scan and 51% on the second-trimester scan. Another 8% was detected in the third trimester. Specificity was 99.9%. The positive predictive value of the screening program was 94.5%, and the negative predictive value was 99.5%. The overall prevalence of malformations was 16.8 per 1000 fetuses, most frequently in the heart and the urinary tract., Conclusions: This study shows that the national screening program for congenital malformations can detect many severe malformations and is an effective screening test for malformations., (© 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).) more...
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- 2023
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5. Parental information about the option to apply for pregnancy termination after the detection of a congenital abnormality and factors influencing parental decision-making: a cohort study.
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Hjort-Pedersen K, Olesen AW, Garne E, Toerring PM, Wu C, and Sperling L
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- Pregnancy, Female, Humans, Cohort Studies, Retrospective Studies, Decision Making, Prenatal Diagnosis, Parents, Abortion, Induced, Congenital Abnormalities diagnosis
- Abstract
Background: The detection of an abnormality during prenatal screening implies that the parents are informed about possible treatment and management of the pregnancy, birth, and postnatal course. This information should enable the parents to make decisions regarding the pregnancy, especially in cases where termination of pregnancy may be an option. The objectives of this study were to investigate how often doctors informed parents about pregnancy termination when the fetus had an anomaly and which demographic factors were related to parental decision-making., Methods: This was a retrospective cohort study with prospectively collected data of fetuses diagnosed with an abnormality during prenatal screening between 2014 and 2016 in Denmark. We categorized the abnormalities into five long-term prognosis groups and analyzed their association with the doctor provided information about termination. We tested the association between demographic variables and parental decisions using univariate and multivariate statistical analyses., Results: Three hundred and twenty fetuses were diagnosed with an abnormality. In 67% of these cases, the parents were informed about termination. All parents whose fetus had a lethal prognosis were informed about termination. By comparison, the parents of 98% of fetuses with genetic disorders, 96% of fetuses with poor prognosis, 69% of fetuses with uncertain prognosis, and 12% of fetuses with good prognosis were informed about termination. Of these parents, 92% chose to terminate. A lethal long-term prognosis was the only factor related to parental decision to terminate a pregnancy., Conclusions: Doctors mainly informed parents about the option of pregnancy termination for conditions with a poor or lethal long-term prognosis or for genetic disorders. Only conditions with a lethal prognosis were significantly related to the parental decision to terminate the pregnancy., (© 2022. The Author(s).) more...
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- 2022
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6. Cerebral disorders in the first 7 years of life in children born post-term: a cohort study.
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Rolschau AH, Olesen AW, Obel C, Olsen J, Wu CS, and Kofoed PE
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- Child, Cohort Studies, Female, Gestational Age, Humans, Infant, Parturition, Pregnancy, Intellectual Disability epidemiology, Intellectual Disability etiology, Pregnancy Outcome
- Abstract
Background: To estimate the association between post-term delivery and risk of physical disabilities, mental disabilities, and seizures during the first 7 years of life., Methods: Data from 57,884 singleton infants born alive in week 39-45 by mothers included in the Danish National Birth Cohort (1997 to 2004) were analyzed, of these 51,268 were born at term (39-41 + 6) and 6616 post-term (42 + 0-44 + 6). Information on clinical endpoints was obtained from an interview at 18 months of gestational age, from a 7-year questionnaire, and from the Danish National Patient Register. Logistic regression and Cox regression were used to estimate odds ratios and hazard rate ratios for the outcome obtained from the interview/questionnaire data and from the register-based data, respectively., Results: We found no statistically significant increased risk of physical disabilities, mental disabilities, and epilepsy among children born post-term, though for most outcomes studied a tendency towards more adverse outcomes was seen. When children born late term (week 41) were compared to children born in week 42 or later the same tendency was found., Conclusion: Post-term born children had a tendency to an excess risk of neurological disabilities as followed for up to 7 years of age. more...
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- 2020
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7. Reasons for non-participation in malformation scans in Denmark: a cohort study.
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Hjort-Pedersen K, Olesen AW, Garne E, and Sperling L
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- Adolescent, Adult, Age Factors, Decision Making, Denmark, Emigrants and Immigrants statistics & numerical data, Female, Humans, Pregnancy, Pregnancy Trimester, Second, Young Adult, Congenital Abnormalities diagnostic imaging, Patient Compliance statistics & numerical data, Ultrasonography, Prenatal
- Abstract
Background: The aim of the study was to estimate the proportion of women giving birth in two hospitals in the Region of Southern Denmark who did not attend the malformation scan and to elucidate the reasons for not participating., Methods: In this register-based descriptive study, we used patient administration systems to identify women who had given birth at two Danish hospitals between March 2013 and January 2015. We then linked this information with the hospital database for fetal medicine (Astraia) to identify women who did not attend the malformation scan at week 18-20. We reviewed the medical records of these women to validate the data and to identify the reason for non-participation., Results: Of 7690 births, 153 (2%) women did not attend the malformation scan. The main reason for non-participation was a passive deselection (81%). Most of these women were not present in Denmark at the time of the malformation scan (61%) and few women declined (8%)., Conclusions: Less than 2% of a birth cohort in two major hospitals in Denmark did not attend the free offer of a malformation scan. Most of these women (81%) did not actively decide against the malformation scan. Very few (0.2%) declined the malformation scan. Non-attendance is not always due to an active decision made by the pregnant woman. more...
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- 2018
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8. Neonatal BCG vaccination and atopic dermatitis before 13 months of age: A randomized clinical trial.
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Thøstesen LM, Kjaergaard J, Pihl GT, Birk NM, Nissen TN, Aaby P, Jensen AKG, Olesen AW, Stensballe LG, Jeppesen DL, Benn CS, and Kofoed PE
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- Dermatitis, Atopic epidemiology, Female, Humans, Infant, Infant, Newborn, Male, Netherlands epidemiology, BCG Vaccine therapeutic use, Dermatitis, Atopic prevention & control
- Abstract
Background: Studies have suggested that Bacillus Calmette-Guérin (BCG) vaccination may reduce the risk of allergic diseases, including atopic dermatitis., Methods: The Danish Calmette Study was conducted 2012-2015. Within 7 days of birth new-borns were randomised 1:1 to BCG or no BCG. Exclusion criteria were gestational age <32 weeks, birth weight <1000 g, known immunodeficiency or no Danish-speaking parent. Data were collected through telephone interviews and clinical examinations until 13 months., Results: Clinical atopic dermatitis was diagnosed in 466/2,052 (22.7%) children in the BCG group and 495/1,952 (25.4%) children in the control group (RR = 0.90 [95% confidence intervals 0.80-1.00]). The effect of neonatal BCG vaccination differed significantly between children with atopic predisposition (RR 0.84 (0.74-0.95)) and children without atopic predisposition (RR 1.09 [0.88-1.37]) (test of no interaction, P = .04)., Conclusion: Among children with atopic predisposition, the number-needed-to-treat with BCG to prevent one case of atopic dermatitis was 21 (12-76)., (© 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.) more...
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- 2018
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9. Neonatal BCG vaccination has no effect on recurrent wheeze in the first year of life: A randomized clinical trial.
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Thøstesen LM, Stensballe LG, Pihl GT, Kjærgaard J, Birk NM, Nissen TN, Jensen AKG, Aaby P, Olesen AW, Jeppesen DL, Benn CS, and Kofoed PE
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- Anti-Asthmatic Agents therapeutic use, Asthma prevention & control, Denmark, Female, Humans, Infant, Infant, Newborn, Male, Recurrence, Th1-Th2 Balance, Treatment Outcome, Vaccination, Asthma immunology, BCG Vaccine immunology, Respiratory Sounds immunology
- Abstract
Background: Recurrent wheeze (RW) is frequent in childhood. Studies have suggested that BCG vaccination can have nonspecific effects, reducing general nontuberculosis morbidity, including respiratory tract infections and atopic diseases. The mechanisms behind these nonspecific effects of BCG are not fully understood, but a shift from a T
H 2 to a TH 1 response has been suggested as a possible explanation., Objective: We hypothesized that BCG at birth would reduce the cumulative incidence of RW during the first year of life., Methods: The Danish Calmette Study is a multicenter randomized trial conducted from 2012-2015 at 3 Danish hospitals. The 4262 newborns of 4184 included mothers were randomized 1:1 to BCG (SSI strain 1331) or to a no-intervention control group within 7 days of birth; siblings were randomized together as one randomization unit. Exclusion criteria were gestational age of less than 32 weeks, birth weight of less than 1000 g, known immunodeficiency, or no Danish-speaking parent. Information was collected through telephone interviews and clinical examinations at 3 and 13 months of age; data collectors were blind to randomization group. RW was defined in several ways, with the main definition being physician-diagnosed and medically treated RW up to 13 months of age., Results: By 13 months, 211 (10.0%) of 2100 children in the BCG group and 195 (9.4%) of 2071 children in the control group had received a diagnosis of RW from a medical doctor and received antiasthma treatment (relative risk, 1.07; 95% CI, 0.89-1.28). Supplementary analyses were made, including an analysis of baseline risk factors for development of RW., Conclusion: Neonatal BCG had no effect on the development of RW before 13 months of age., (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.) more...- Published
- 2017
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10. Neonatal BCG has no effect on allergic sensitization and suspected food allergy until 13 months.
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Thøstesen LM, Kjaer HF, Pihl GT, Nissen TN, Birk NM, Kjaergaard J, Jensen AKG, Aaby P, Olesen AW, Stensballe LG, Jeppesen DL, Benn CS, and Kofoed PE
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- BCG Vaccine immunology, Denmark epidemiology, Female, Follow-Up Studies, Food Hypersensitivity diagnosis, Food Hypersensitivity epidemiology, Food Hypersensitivity immunology, Humans, Hypersensitivity, Immediate diagnosis, Hypersensitivity, Immediate epidemiology, Hypersensitivity, Immediate immunology, Hypersensitivity, Immediate prevention & control, Incidence, Infant, Infant, Newborn, Male, Single-Blind Method, Treatment Outcome, BCG Vaccine therapeutic use, Food Hypersensitivity prevention & control
- Abstract
Background: Vaccination with Bacillus Calmette-Guérin (BCG) is used in many countries as protection against tuberculosis. Studies have suggested that BCG may also have non-specific effects, reducing non-tuberculosis mortality, morbidity, and atopic manifestations. In this study, we evaluated the effect of neonatal BCG vaccination on allergic sensitization and suspected food allergy at 13 months of age., Methods: The Danish Calmette Study was conducted from 2012 to 2015 at three Danish hospitals. Within 7 days of birth, the 4262 newborns of 4184 included mothers were randomized 1:1 to BCG or to a no-intervention control group. Exclusion criteria were gestational age <32 weeks, birth weight <1000 g, known immunodeficiency, or no Danish-speaking parent. Follow-up information was collected through telephone interviews at 3 and 13 months of age. Subgroups of participants were offered blood sampling at 13 months of age., Results: By 13 months of age, the parents and/or general practitioners of 5.6% (117/2089) of the children in the BCG group and 6.1% (126/2061) of the control group suspected food allergy, resulting in a risk ratio comparing BCG-vaccinated children with control children of 0.91 (95% CI 0.71-1.16). Among 1370 blood samples, sensitization (Phadiatop Infant >0.35 kUA/L) was found in 55 of 743 (7.4%) children in the BCG group and 50 of 627 (8.0%) of the control group (risk ratio 0.94 [0.65-1.36])., Conclusion: In this randomized clinical trial, neonatal BCG had no significant effect on suspected food allergy or on sensitization at 13 months of age., (© 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.) more...
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- 2017
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11. The Danish Fetal Medicine Database: establishment, organization and quality assessment of the first trimester screening program for trisomy 21 in Denmark 2008-2012.
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Ekelund CK, Petersen OB, Jørgensen FS, Kjaergaard S, Larsen T, Olesen AW, Skibsted L, Skovbo P, Sommer S, Sperling L, Stavnstrup B, Størup B, Zingenberg H, Uldbjerg N, Miltoft CB, Noergaard L, Wulff CB, and Tabor A more...
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- Denmark epidemiology, Down Syndrome epidemiology, Female, Humans, Pregnancy, Pregnancy Trimester, First, Prospective Studies, Registries, Risk Assessment, Biomedical Research, Databases, Factual, Down Syndrome diagnosis, Mass Screening, Perinatology
- Abstract
Objective: To describe the establishment and organization of the Danish Fetal Medicine Database and to report national results of first-trimester combined screening for trisomy 21 in the 5-year period 2008-2012., Design: National register study using prospectively collected first-trimester screening data from the Danish Fetal Medicine Database., Population: Pregnant women in Denmark undergoing first-trimester screening for trisomy 21., Methods: Data on maternal characteristics, biochemical and ultrasonic markers are continuously sent electronically from local fetal medicine databases (Astraia Gmbh software) to a central national database. Data are linked to outcome data from the National Birth Register, the National Patient Register and the National Cytogenetic Register via the mother's unique personal registration number. First-trimester screening data from 2008 to 2012 were retrieved., Main Outcome Measures: Screening performance was assessed for the years 2008-2012 by calculating detection rates and screen-positive rates., Results: A total of 268 342 first-trimester risk assessments for trisomy 21 were performed in singleton pregnancies. Participation rate in first-trimester screening was >90%. The national screen-positive rate increased from 3.6% in 2008 to 4.7% in 2012. The national detection rate of trisomy 21 was reported to be between 82 and 90% in the 5-year period., Conclusion: A national fetal medicine database has been successfully established in Denmark. Results from the database have shown that at a national level first-trimester screening performance for trisomy 21 is high with a low screen-positive rate and a high detection rate., (© 2015 Nordic Federation of Societies of Obstetrics and Gynecology.) more...
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- 2015
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12. [Pregnancy jeopardized by pseudoxanthoma elasticum].
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Drue HC, Mogensen H, and Olesen AW
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- Adult, Calcinosis diagnostic imaging, Cerebral Hemorrhage etiology, Cesarean Section, Female, Humans, Hydrocephalus etiology, Infant, Newborn, Perinatal Death, Placenta Diseases diagnostic imaging, Placenta Diseases pathology, Pregnancy, Pregnancy, Twin, Ultrasonography, Prenatal, Calcinosis etiology, Placenta Diseases etiology, Pseudoxanthoma Elasticum complications
- Abstract
Pseudoxanthoma elasticum (PXE) is a rare inherited systemic disorder characterized by progressive calcification in the elastic tissue. Information about pregnancy in women with PXE is sparse. We report of a 36-year-old Caucasian woman, diagnosed with PXE, with a dichorionic diamniotic twin pregnancy, whose antenatal ultrasound scans showed a hyperechogenic placenta due to calcification. The calcification was confirmed on post-partum placental histology. Both twins, delivered via caesarean section due to maternal bleeding at 27 weeks of gestation suffered from intraventricular haemorrhage. more...
- Published
- 2014
13. Risk for developmental coordination disorder correlates with gestational age at birth.
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Zhu JL, Olsen J, and Olesen AW
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- Adolescent, Child, Child, Preschool, Confidence Intervals, Denmark, Follow-Up Studies, Humans, Infant, Newborn, Infant, Postmature, Infant, Premature, Longitudinal Studies, Motor Skills Disorders physiopathology, Risk Factors, Severity of Illness Index, Surveys and Questionnaires, Gestational Age, Motor Skills Disorders etiology
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Background: Studies suggest that children born very preterm have a high risk of developmental coordination disorder (DCD). We examined the relation between the larger spectrum of gestational age at birth and the risk of DCD., Methods: We used the 7-year follow-up data from 22898 singletons in the Danish National Birth Cohort. We calculated a total score from the Developmental Coordination Disorder Questionnaire (DCDQ), incorporated in the 7-year follow-up, and defined children with a score of 46 or below as having probable DCD. Information on gestational age was obtained from the Medical Birth Register., Results: Gestational age at birth was inversely associated with the risk of DCD; a decline in gestational age by a week was associated with a 19% [95% confidence interval 14%, 25%] increased risk of DCD screening positive among children delivered before 40 weeks. No significant increased risk of DCD was seen for children born post-term., Conclusion: Our data indicate that short gestational age at birth in a range up to gestational week 37 is related to an increased risk of DCD., (© 2012 Blackwell Publishing Ltd.) more...
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- 2012
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14. [Down's syndrome risk assessment in Denmark--secondary publication].
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Ekelund CK, Andersen HJ, Christensen J, Ersbak V, Farlie R, Henriques C, Holmskov A, Jensen LN, Jørgensen FS, Hessellund A, Larsen T, Olesen AW, Pedersen OB, Poulsen H, Ramb J, Skibsted L, Skovbo P, Sommer S, Sperling L, Sundberg K, Juul SV, Zingenberg H, and Tabor A more...
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- Amniocentesis, Chorionic Villi Sampling, Denmark, Female, Humans, Practice Guidelines as Topic, Pregnancy, Pregnancy Trimester, First, Risk Assessment, Down Syndrome diagnosis, Prenatal Diagnosis methods
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In 2004 The Danish National Board of Health introduced a new guideline regarding prenatal screening. All pregnant women are now offered a Down's syndrome risk assessment. The new guideline has had an impact on the number of invasive early prenatal procedures. The number of procedures fell by 50% from 2000 to 2006. 90% of the foetuses with Down's syndrome are detected prenatally. Denmark is one of the first countries in the world in which risk assessment for Down's syndrome has been successfully implemented at a national level. more...
- Published
- 2010
15. Prediction of delivery date by sonography in the first and second trimesters.
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Olesen AW and Thomsen SG
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- Adult, Female, Humans, Infant, Newborn, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, First, Pregnancy Trimester, Second, Statistics, Nonparametric, Crown-Rump Length, Menstrual Cycle physiology, Term Birth, Ultrasonography, Prenatal standards
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Objective: To compare the dates of delivery predicted by last menstrual period (LMP), crown-rump length (CRL) and biparietal diameter (BPD) with the actual date of delivery in a population of pregnant women divided into those with certain and those with uncertain LMP., Methods: Healthy women were enrolled at the first visit during their pregnancy to a general practitioner in Odense, Denmark, and underwent ultrasound examinations in the first and second trimesters. Data from a study of 798 women who gave birth in the period August 2001 to April 2003 are presented, although only the 657 spontaneous deliveries were used for analysis (n = 339 and 318 in the certain and uncertain LMP groups, respectively). Data on pregnancy and delivery were collected from the medical records. Wilcoxon's signed rank test was used to test the hypothesis of no difference in prediction error (predicted - actual date of delivery) between the three methods., Results: The median prediction errors estimated by sonography in the first and second trimesters and by corrected LMP according to cycle length were 2.32, 0.16, and 3.00 days, respectively, in women with certain LMP, and 1.71, 0.00, and 3.00 days, respectively, in women with uncertain LMP. The median gestational age at delivery estimated by sonography in the first and second trimesters and by corrected LMP according to cycle length was 282, 280, and 283 days, respectively, in both groups., Conclusion: An ultrasound examination in the second trimester (17-22 completed weeks) is the best predictor of the date of delivery at the individual level, followed by an ultrasound examination in the first trimester. Having an uncertain LMP does not affect the sonographic prediction of date of delivery., (Copyright 2006 ISUOG. Published by John Wiley & Sons, Ltd.) more...
- Published
- 2006
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16. Prenatal risk indicators of a prolonged pregnancy. The Danish Birth Cohort 1998-2001.
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Olesen AW, Westergaard JG, and Olsen J
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- Adolescent, Adult, Body Mass Index, Denmark epidemiology, Female, Humans, Parity, Pregnancy, Pregnancy, Prolonged epidemiology, Risk Factors, Pregnancy, Prolonged etiology
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Background: Few prenatal risk factors of prolonged pregnancy, a pregnancy of 42 weeks or more, are known. The objective was to examine whether sociodemographic, reproductive, toxicologic, or medical health conditions were associated with the risk of prolonged pregnancy., Methods: Data from the Danish Birth Cohort in Denmark were used. Interview data from 53,392 participants with live-born singleton deliveries in the period 1998-2001 were available at the time of this study. The participants were interviewed by telephone at 12 and 30 weeks' gestation, and 6 and 18 months after delivery. Statistical analyses were done using logistic regression., Results: Women with a pre-pregnancy body mass index of 25 kg/m2 or more had a high risk of prolonged pregnancy. If the pre-pregnancy body mass index was 35 kg/m2 or more the odds ratio was 1.52 (95% CI 1.28-1.82). Nulliparity also increased the risk of prolonged pregnancy (OR (95% CI) = 1.35 (1.27-1.44))., Conclusions: The risk of post-term delivery was high in women with a pre-pregnancy body mass index of 25 kg/m2 or more, and in nulliparous women. more...
- Published
- 2006
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17. Correlation between self-reported gestational age and ultrasound measurements.
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Olesen AW, Westergaard JG, Thomsen SG, and Olsen J
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- Adult, Cohort Studies, Denmark epidemiology, Female, Humans, Medical Records, Pregnancy, Reproducibility of Results, Surveys and Questionnaires, Gestational Age, Registries statistics & numerical data, Ultrasonography, Prenatal standards
- Abstract
Background: We studied the agreement between different measurements of gestational age, i.e. self-reported gestational age in the Danish National Birth Cohort Study, ultrasound-estimated gestational age from the medical records in one Danish county and gestational age from the Danish National Hospital Discharge Register., Methods: The ultrasound-estimated gestational length was based on the size of the biparietal diameter. The ultrasound-estimated gestational length was related to corrected and uncorrected last menstrual period estimates in the Danish National Cohort Study, and to the gestational length recorded in the Danish National Discharge Register. Non-parametric statistics were used in the analysis., Results: The gestational ages estimated by ultrasound were 2-3 days shorter than gestational ages estimated by the other methods. The gestational ages recorded by the Discharge Register and the gestational ages based on corrected last menstrual period did not differ significantly., Conclusion: The self-reported gestational age in The Danish National Birth Cohort is in good concordance both with data from the National Hospital Discharge Register and with ultrasound-estimated gestational age. more...
- Published
- 2004
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18. Genetic influence on prolonged gestation: a population-based Danish twin study.
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Laursen M, Bille C, Olesen AW, Hjelmborg J, Skytthe A, and Christensen K
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- Denmark, Female, Humans, Male, Pregnancy, Twins, Dizygotic, Twins, Monozygotic, Pregnancy, Prolonged genetics
- Abstract
Objective: The purpose of this study was to test a possible genetic component to prolonged gestation., Study Design: The gestational duration of single, first pregnancies by both female and male twins was obtained by linking the Danish Twin Registry, The Danish Civil Registration System, and the Danish Medical Birth Register. A total of 2588 same-sex twin pairs of whom both cotwins became parents during 1978 to 1996 were identified., Results: The concordance rate for female twin pairs for a gestation of > or =41 weeks and > or =42 weeks was higher for monozygotic twin pairs than for dizygotic twin pairs, which indicates genetic effects. Biometric modeling suggested that genetic factors account for 23% to 30% of the liability to prolonged gestation. The difference in concordance rate between monozygotic and dizygotic male twin pairs was small, and the best fitting model indicated no genetic factors., Conclusion: Maternal genes influence prolonged gestation. However, a substantial paternal genetic influence through the fetus was not found. more...
- Published
- 2004
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19. Perinatal and maternal complications related to postterm delivery: a national register-based study, 1978-1993.
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Olesen AW, Westergaard JG, and Olsen J
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- Adult, Asphyxia Neonatorum epidemiology, Birth Weight, Bone and Bones injuries, Cross-Sectional Studies, Denmark, Dystocia epidemiology, Female, Gestational Age, Humans, Infant, Newborn, Logistic Models, Odds Ratio, Peripheral Nerve Injuries, Placenta Diseases epidemiology, Postpartum Hemorrhage epidemiology, Pregnancy, Respiratory Distress Syndrome, Newborn epidemiology, Pregnancy, Prolonged, Registries
- Abstract
Objective: This study was undertaken to estimate the risk of fetal and maternal complications associated with postterm delivery in Denmark., Study Design: A cross-sectional study that used records from the Danish Medical Birth Registry from 1978 to 1993 was performed. All women with registered prolonged pregnancy (n = 78022) and a 5% random sample of all women who gave birth (n = 47021) were linked to the Danish National Discharge Register. We established a postterm group of 77956 singleton deliveries and a term group of 34140 singleton spontaneous deliveries. Logistic regression models were used to analyze data., Results: The risk of perinatal and obstetric complications was high in postterm delivery compared with term delivery (adjusted odds ratios between 1.2 and 3.1). The risk of perinatal death was 1.33 (1.05-1.68)., Conclusion: Postterm delivery was associated with significantly increased risks of perinatal and maternal complications in Denmark in the period from 1978 to 1993. more...
- Published
- 2003
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20. Risk of recurrence of prolonged pregnancy.
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Olesen AW, Basso O, and Olsen J
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- Adult, Cohort Studies, Denmark epidemiology, Female, Humans, Pregnancy, Recurrence, Residence Characteristics, Risk Factors, Sexual Partners, Social Class, Pregnancy, Prolonged
- Published
- 2003
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21. [Continuously diminishing menarcheal age in Denmark].
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Olesen AW, Jeune B, and Boldsen JL
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- Adolescent, Adult, Age Factors, Child, Denmark, Female, Humans, Retrospective Studies, Menarche physiology
- Abstract
Introduction: The aim was to follow the development of the parameters of the distribution of age at menarche in Danish women in recent decades., Material and Methods: The study is based on retrospective data from six different samples with a total of 42,784 women, born in the period 1923-1973., Results: We report a renewed decline in the mean menarcheal age in a large Danish sample after a period with a halt in the trend towards an earlier age at menarche in many North European countries. We find a continuously declining mean menarcheal age in Denmark in women born in the years 1964-1973. In a sample of textile workers born in the years 1939-1968 (n = 12,605) we find a higher mean menarcheal age of one year., Discussion: The results indicate that menarcheal age is still delayed in certain groups in Denmark. It can therefore be expected that the menarcheal age will fall even more in the future. more...
- Published
- 2001
22. A continuous decline in menarcheal age in Denmark.
- Author
-
Olesen AW, Jeune B, and Boldsen JL
- Subjects
- Adult, Denmark, Female, Humans, Retrospective Studies, Aging, Menarche physiology
- Abstract
We report a renewed decline in mean menarcheal age in a large Danish sample after a period with a halt in the trend towards earlier age at menarche in many North European countries. In our study based on retrospective data from six different samples constituting 42784 women, we find a continuously declining mean menarcheal age in Denmark among women born in the years 1964-1973. In a sample of textile workers born in the years 1939-1968 (n = 12605) we find a 1 year higher mean menarcheal age. This indicates that menarcheal age is still delayed in certain groups in Denmark. This leaves the possibility that the menarcheal age could fall even further in the future. more...
- Published
- 2000
- Full Text
- View/download PDF
23. An estimate of the tendency to repeat postterm delivery.
- Author
-
Olesen AW, Basso O, and Olsen J
- Subjects
- Denmark epidemiology, Female, Humans, Pregnancy, Recurrence, Retrospective Studies, Risk Assessment, Pregnancy, Prolonged
- Published
- 1999
- Full Text
- View/download PDF
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