Search

Your search keyword '"Olga Gagliardo"' showing total 3 results
Start Over Author "Olga Gagliardo"
3 results on '"Olga Gagliardo"'

1. Cerebral Venous Thrombosis: A Challenging Diagnosis; A New Nonenhanced Computed Tomography Standardized Semi-Quantitative Method

Author

Andrea Romano, Maria Camilla Rossi-Espagnet, Luca Pasquini, Alberto Di Napoli, Francesco Dellepiane, Giulia Butera, Giulia Moltoni, Olga Gagliardo, and Alessandro Bozzao

Subjects
cerebral venous thrombosis, diagnosis, standardized method, CT, ROI based, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Cerebral venous sinus thrombosis (CVST) on non-contrast CT (NCCT) is often challenging to detect. We retrospectively selected 41 children and 36 adults with confirmed CVST and two age-matched control groups with comparable initial symptoms. We evaluated NCCT placing four small circular ROIs in standardized regions of the cerebral dural venous system. The mean and maximum HU values were considered from each ROI, and the relative percentage variations were calculated (mean % variation and maximum % variation). We compared the highest measured value to the remaining three HU values through an ad-hoc formula based on the assumption that the thrombosed sinus has higher attenuation compared with the healthy sinuses. Percentage variations were employed to reflect how the attenuation of the thrombosed sinus deviates from the unaffected counterparts. The attenuation of the affected sinus was increased in patients with CVST, and consequently both the mean % and maximum % variations were increased. A mean % variation value of 12.97 and a maximum % variation value of 10.14 were found to be useful to distinguish patients with CVST from healthy subjects, with high sensitivity and specificity. Increased densitometric values were present in the site of venous thrombosis. A systematic, blind evaluation of the brain venous system can assist radiologists in identifying patients who need or do not need further imaging.

Published
2021
Full Text
View/download PDF

2. Evaluation of skull base tumors with dynamic TurboFLASH MRI during gadolinium injection

Author

Alessandro Bozzao, Edoardo Covelli, Guido Trasimeni, Grossi A, Marina Auconi, Andrea Romano, and Olga Gagliardo

Subjects
Gadolinium, chemistry.chemical_element, Intraoperative bleeding, Lesion, 03 medical and health sciences, 0302 clinical medicine, medicine, magnetic resonance imaging, glomus tumors, intraoperative bleeding, skull base, turboFLASH, ultrafast dynamic sequences, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, medicine.disease, Glomus tumor, Skull, medicine.anatomical_structure, chemistry, Cavernous sinus, Neurology (clinical), medicine.symptom, Differential diagnosis, business, Nuclear medicine, 030217 neurology & neurosurgery
Abstract

Background and Purpose This study was aimed to investigate the role of dynamic TurboFLASH gadolinium (Gd) magnetic resonance (MR) imaging in improving the differential diagnosis of skull base tumors. Methods Eleven patients with skull base tumors underwent standard MR and ultrafast TurboFLASH sequence during gadolinium injection. Results The characterization of tumor vascularity was performed. Different patterns of gadolinium uptake for each tumor type were observed. This is particularly important to identify tumors at high risk of intraoperative bleeding. All glomus tumors, typically highly vascularized, showed an enhancement at the arterial phase, reflecting the arterialization of these tumors which is not detectable on conventional MR. No signal increase at the arterial phase was instead observed in other cases in which the ruling out of a glomus tumor was important because of the location of the lesion. Moreover TurboFLASH identified the pathognomonic “filling-in” profile of cavernous sinus cavernous hemangiomas (CSCH), that is, the progressive centripetal enhancement of the lesion at the beginning of the venous phase. Conclusion The dynamic analysis of tumor contrast enhancement with the TurboFLASH sequence provides useful additional information to that obtained with conventional MR, improving the differential diagnosis of skull base tumors, particularly in the distinction between glomus and nonglomus tumors and in diagnosing CSCH.

Published
2020

3. Age effects on cortical thickness in young Down's syndrome subjects: a cross-sectional gender study

Author

Marta Moraschi, Laura Chiacchiararelli, Riccardo Cornia, Cristina Iani, Alessandro Bozzao, Giorgio Albertini, Giacomo Stella, Andrea Romano, Alberto Pierallini, and Olga Gagliardo

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Pediatrics, Neurology, Adolescent, Cortical thinning, Gender, Down’s syndrome, MRI, Free-surfer, Aging, Sex Factors, medicine, gender, Humans, Radiology, Nuclear Medicine and imaging, Child, Down's syndrome, Neuroradiology, S syndrome, business.industry, aging, Age Factors, free-surfer, Brain, Magnetic Resonance Imaging, Large cohort, Cross-Sectional Studies, MRI, Female, Neurology (clinical), Neurosurgery, Down Syndrome, Cardiology and Cardiovascular Medicine, business
Abstract

The aim of this study was to determine differences in the characteristic pattern of age-related cortical thinning in men and women with Down's syndrome (DS) by means of MRI and automatic cortical thickness measurements and a cross-sectional design, in a large cohort of young subjects.Eighty-four subjects with DS, 30 females (11-35 years, mean age ± SD = 22.8 ± 5.9) and 54 males (11-35 years, mean age ± SD = 21.5 ± 6.5), were examined using a 1.5-T scanner. MRI-based quantification of cortical thickness was performed using FreeSurfer software package. For all subjects participating in the study, the Pearson product-moment correlation coefficient between age and mean cortical thickness values has been evaluated.A significant negative correlation between cortical thickness and age was found in female DS subjects, predominantly in frontal and parietal lobes, bilaterally. In male DS subjects, a significant negative correlation between cortical thickness and age was found in the right fronto-temporal lobes and cingulate regions. Whole brain mean cortical thickness values were significantly negative correlated with age only in female DS subjects.Females with Down's syndrome showed a strong correlation between cortical thickness and age, already in early age. We suggest that the cognitive impairment due to hormonal deficit in the postmenopausal period could be emphasized by the early structural decline of gray matter in female DS subjects.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results