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1. Recommendations on cutaneous and hematological manifestations of Sjögren’s disease by the Brazilian Society of Rheumatology

Author

Pugliesi, Alisson, Egypto, Danielle Christinne Soares do, Duffles, Guilherme, Cantali, Diego Ustárroz, Pasoto, Sandra Gofinet, Oliveira, Fabiola Reis, Valim, Valeria, Lopes, Maria Lucia Lemos, Miyamoto, Samira Tatiyama, Fernandes, Marilena Leal Mesquita Silvestre, Fialho, Sonia Cristina de Magalhães Souza, Pinheiro, Aysa César, Santos, Laura Caldas dos, Appenzeller, Simone, Ribeiro, Sandra Lucia Euzébio, Libório-Kimura, Tatiana Nayara, Santos, Maria Carmen Lopes Ferreira Silva, Gennari, Juliana D´Agostino, Pernanbuco, Roberta, Capobiano, Karina Gatz, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha-Filho, César Ramos, Rocha, Aline Pereira da, and Trevisani, Virginia Fernandes Moça

Published
2024
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2. LAMP3 induces ectopic TLR7 expression in salivary gland epithelial cells and amplifies type I IFN production in Sjögren's disease

Author

Nakamura, Hiroyuki, primary, Tanaka, Tsutomu, additional, Zheng, Changyu, additional, Afione, Sandra A., additional, Atsumi, Tatsuya, additional, Noguchi, Masayuki, additional, Oliveira, Fabiola Reis, additional, Motta, Ana Carolina F., additional, Chahud, Fernando, additional, Rocha, Eduardo M., additional, Warner, Blake M., additional, and Chiorini, John A., additional

Published
2024
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3. Correction to: 2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome

Author

Oliveira, Fabiola Reis, Valim, Valeria, Pasoto, Sandra Gofnet, Fernandes, Marilena Leal Mesquita Silvestre, Lopes, Maria Lucia Lemos, de Magalhães Souza Fialho, Sonia Cristina, Pinheiro, Aysa César, dos Santos, Laura Caldas, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lucia Euzébio, de Brito, Danielle Christinne Soares Egypto, Libório, Tatiana, Santos, Maria Carmen Lopes Ferreira Silva, Tanure, Leandro, Gennari, Juliana DAgostino, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha-Filho, César Ramos, Miyamoto, Samira Tatiyama, Guedes, Lissiane Karine Noronha, Pugliesi, Alisson, and Trevisani, Virginia Fernandes Moça

Published
2022
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4. Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic)

Author

Trevisani, Virginia Fernandes Moça, Pinheiro, Aysa César, de Magalhães Souza Fialho, Sonia Cristina, Fernandes, Marilena Leal Mesquita Silvestre, Pugliesi, Alisson, Pasoto, Sandra Gofinet, Lopes, Maria Lucia Lemos, Guedes, Lissiane Karine Noronha, Miyamoto, Samira Tatiyama, dos Santos, Laura Caldas, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lúcia Euzébio, de Brito, Danielle Christinne Soares Egypto, Libório-Kimura, Tatiana Nayara, Santos, Maria Carmen Lopes Ferreira Silva, Cantali, Diego Ustárroz, Gennari, Juliana D.’Agostino, Capobianco, Karina Gatz, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, da Rocha, Aline Pereira, Rocha-Filho, César Ramos, Oliveira, Fabiola Reis, and Valim, Valeria

Published
2022
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5. Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)

Author

Trevisani, Virginia Fernandes Moça, Pugliesi, Alisson, Pasoto, Sandra Gofinet, Lopes, Maria Lucia Lemos, Guedes, Lissiane Karine Noronha, Miyamoto, Samira Tatiyama, Fernandes, Marilena Leal Mesquita Silvestre, Fialho, Sonia Cristina de Magalhães Souza, Pinheiro, Aysa César, dos Santos, Laura Caldas, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lúcia Euzébio, de Brito, Danielle Christinne Soares Egypto, Nayara Libório-Kimura, Tatiana, Santos, Maria Carmen Lopes Ferreira Silva, Cantali, Diego Ustárroz, Gennari, Juliana D’Agostino, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha-Filho, César Ramos, Oliveira, Fabiola Reis, da Rocha, Aline Pereira, and Valim, Valeria

Published
2022
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6. Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll‐Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome‐Associated Membrane Protein 3.

Author

Nakamura, Hiroyuki, Tanaka, Tsutomu, Zheng, Changyu, Afione, Sandra A., Atsumi, Tatsuya, Noguchi, Masayuki, Oliveira, Fabiola Reis, Motta, Ana Carolina F., Chahud, Fernando, Rocha, Eduardo M., Warner, Blake M., and Chiorini, John A.

Subjects
RNA analysis, EPITHELIAL cells, LYSOSOMES, BIOLOGICAL models, IN vitro studies, TOLL-like receptors, CELLULAR signal transduction, IN vivo studies, DESCRIPTIVE statistics, INTERFERONS, GENE expression, MICE, ANIMAL experimentation, GENE expression profiling, SJOGREN'S syndrome, SALIVARY glands, MEMBRANE proteins, SEQUENCE analysis, SYMPTOMS
Abstract

Objective: Lysosome‐associated membrane protein 3 (LAMP3) misexpression in salivary gland epithelial cells plays a causal role in the development of salivary gland dysfunction and autoimmunity associated with Sjögren's disease (SjD). This study aimed to clarify how epithelial LAMP3 misexpression is induced in SjD. Methods: To explore upstream signaling pathways associated with LAMP3 expression, we conducted multiple RNA sequencing analyses of minor salivary glands from patients with SjD, submandibular glands from a mouse model of SjD, and salivary gland epithelial cell lines. A hypothesis generated by the RNA sequencing analyses was further tested by in vitro and in vivo assays with gene manipulation. Results: Transcriptome analysis suggested LAMP3 expression was associated with enhanced type I interferon (IFN) and IFNγ signaling pathways in patients with SjD. In vitro studies showed that type I IFN but not IFNγ stimulation could induce LAMP3 expression in salivary gland epithelial cells. Moreover, we discovered that LAMP3 overexpression could induce ectopic Toll‐like receptor 7 (TLR‐7) expression and type I IFN production in salivary gland epithelial cells both in vitro and in vivo. TLR‐7 knockout mice did not develop any SjD‐related symptoms following LAMP3 induction. Conclusion: Epithelial LAMP3 misexpression can be induced through enhanced type I IFN response in salivary glands. In addition, LAMP3 can promote type I IFN production via ectopic TLR‐7 expression in salivary gland epithelial cells. This positive feedback loop can contribute to maintaining LAMP3 misexpression and amplifying type I IFN production in salivary glands, which plays an essential role in the pathophysiology of SjD. [ABSTRACT FROM AUTHOR]

Published
2024
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7. 2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome

Author

Oliveira, Fabiola Reis, Valim, Valeria, Pasoto, Sandra Gofinet, Fernandes, Marilena Leal Mesquita Silvestre, Lopes, Maria Lucia Lemos, de Magalhães Souza Fialho, Sonia Cristina, Pinheiro, Aysa César, dos Santos, Laura Caldas, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lucia Euzébio, de Brito, Danielle Christinne Soares Egypto, Libório, Tatiana, Santos, Maria Carmen Lopes Ferreira Silva, Tanure, Leandro, Gennari, Juliana DAgostino, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha-Filho, César Ramos, Miyamoto, Samira Tatiyama, Guedes, Lissiane Karine Noronha, Pugliesi, Alisson, and Trevisani, Virginia Fernandes Moça

Published
2021
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8. Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjogren's syndrome

Author

Mo, Ying-Qian, Nakamura, Hiroyuki, Tanaka, Tsutomu, Odani, Toshio, Perez, Paola, Ji, Youngmi, French, Benjamin N., Pranzatelli, Thomas J.F., Michael, Drew G., Yin, Hongen, Chow, Susan S., Khalaj, Maryam, Afione, Sandra A., Zheng, Changyu, Oliveira, Fabiola Reis, Motta, Ana Carolina F., Ribeiro-Silva, Alfredo, Rocha, Eduardo M., Nguyen, Cuong Q., Noguchi, Masayuki, Atsumi, Tatsuya, Warner, Blake M., and Chiorini, John A.

Subjects
Gene expression -- Research, Immunological research, Autoimmunity -- Genetic aspects -- Health aspects, Heat shock proteins -- Genetic aspects -- Health aspects, Sjogren's syndrome -- Development and progression -- Genetic aspects, Exocytosis -- Research, Lysosomes -- Genetic aspects -- Health aspects, Health care industry
Abstract

BMP6 is a central cytokine in the induction of Sjogren's syndrome-associated (SS-associated) secretory hypofunction. However, the upstream initiation leading to the production of this cytokine in SS is unknown. In this study, RNA ISH on salivary gland sections taken from patients with SS indicated monocytic lineage cells as a cellular source of BMP6. RNA-Seq data on human salivary glands suggested that TLR4 signaling was an upstream regulator of BMP6, which was confirmed by in vitro cell assays and single-cell transcriptomics of human PBMCs. Further investigation showed that HSP70 was an endogenous natural TLR4 ligand that stimulated BMP6 expression in SS. Release of HSP70 from epithelial cells could be triggered by overexpression of lysosome-associated membrane protein 3 (LAMP3), a protein also associated with SS in several transcriptome studies. In vitro studies supported the idea that HSP70 was released as a result of lysosomal exocytosis initiated by LAMP3 expression, and reverse transcription PCR on RNA from minor salivary glands of patients with SS confirmed a positive correlation between BMP6 and LAMP3 expression. BMP6 expression could be experimentally induced in mice by overexpression of LAMP3, which developed an SS-like phenotype. The newly identified LAMP3/HSP70/BMP6 axis provided an etiological model for SS gland dysfunction and autoimmunity., Introduction Sjogren's syndrome (SS) is an autoimmune disease characterized by dry mouth and/or eye symptoms (sicca symptoms) and lymphocytic inflammation in salivary and/or lacrimal glands. The pathogenetic mechanism driving the [...]

Published
2022
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10. Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren’s disease

Author

Nakamura, Hiroyuki, primary, Tanaka, Tsutomu, additional, Ji, Youngmi, additional, Zheng, Changyu, additional, Afione, Sandra A., additional, Warner, Blake M., additional, Oliveira, Fabiola Reis, additional, Motta, Ana Carolina F., additional, Rocha, Eduardo M., additional, Noguchi, Masayuki, additional, Atsumi, Tatsuya, additional, and Chiorini, John A., additional

Published
2023
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11. GENE EXPRESSION OF ENDOPLASMIC RETICULUM STRESS IN SJÖGREN SYNDROME PATIENTS

Author

Cavalcanti, Graziela Vieira, primary, Oliveira, Fabiola Reis de, additional, Bannitz, Rafael Ferraz, additional, Paula, Natalia Aparecida de, additional, Motta, Ana Carolina Fragoso, additional, Rocha, Eduardo Melani, additional, Ricz, Hilton Marcos Alves, additional, Freitas, Maria Cristina Foss, additional, and Freitas, Luiz Carlos Conti de, additional

Published
2023
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12. ARTICULAR SYSTEMIC DISEASE ACTIVITY AT DIAGNOSIS IS ASSOCIATED WITH DAMAGE, FATIGUE, PAIN AND DRYNESS OVER TIME IN PRIMARY SJÖGREN’S SYNDROME

Author

Valim, Valéria, primary, Miyamoto, Samira Tatiyama, additional, Serrano, Erica Vieira, additional, Machado, Ketty Lysie Libardi Lira, additional, Gianordoli, Ana Paula Espindul, additional, Aguiar, Laura Gonçalves Rodrigues, additional, Reis, Pâmela Peres dos, additional, Nóia, João Pedro de Castro Carvalho, additional, Oliveira, Fabiola Reis de, additional, Rocha, Eduardo Melani, additional, Motta, Ana Carolina Fragoso, additional, Xavier, Clarice Garcia Valadares, additional, Ferreira, Gilda Aparecida, additional, Tanure, Leandro Augusto, additional, Pinheiro, Aysa César, additional, Santos, Paula Regina Toche dos, additional, Capobianco, Karina Gatz, additional, Spohr, Rodrigo Sarmanho, additional, Souto, Laura de Brito, additional, Costa, Poliane Cruz, additional, Medeiros, Clarissa Castro Galvão, additional, Picolo, Maria Lara, additional, Goularte, Leonardo Santiago, additional, Ferrari, Alessandra, additional, Jeffman, Marcelo Wainberg, additional, Costa Filho, Luiz Cesar da, additional, Hax, Vanessa, additional, Ribeiro, Sandra Lúcia Euzébio, additional, Silva, Jessica Carvalho da, additional, Souza, Bruna Lyandra Portela Sena de, additional, Carneiro, Barbara Seabra, additional, Melo, Natália Seixas de, additional, Dias, Marcos Magvinier Sousa, additional, and Silva, Tayana Evelling Uchôa da, additional

Published
2022
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13. FATIGUE IS ASSOCIATED WITH SYMPTOMS, DEPRESSION, ANXIETY, SLEEPINESS AND DISEASE ACTIVITY IN PRIMARY SJÖGREN’S SYNDROME

Author

Miyamoto, Samira Tatiyama, primary, Valim, Valéria, additional, Serrano, Erica Vieira, additional, Machado, Ketty Lysie Libardi Lira, additional, Gianordoli, Ana Paula Espindula, additional, Aguiar, Laura Gonçalves Rodrigues, additional, Reis, Pâmela Peres dos, additional, Nóia, João Pedro de Castro Carvalho, additional, Oliveira, Fabiola Reis de, additional, Rocha, Eduardo Melani, additional, Motta, Ana Carolina Fragoso, additional, Pinheiro, Aysa César, additional, Santos, Paula Regina Toche do, additional, Trevisani, Virginia Fernandes Moça, additional, Dardin, Luciana Paula, additional, Ribeiro, Sandra Lúcia Euzébio, additional, Silva, Jessica Carvalho da, additional, Souza, Bruna Lyandra Portela Sena de, additional, Carneiro, Barbara Seabra, additional, Melo, Natália Seixas de, additional, Dias, Marcos Magvinier Sousa, additional, and Silva, Tayana Evelling Uchôa da, additional

Published
2022
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14. Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic)

Author

Trevisani, Virginia Fernandes Moça, Pinheiro, Aysa César, Fialho, Sonia Cristina de Magalhães Souza, Fernandes, Marilena Leal Mesquita Silvestre, Pugliesi, Alisson, Pasoto, Sandra Gofinet, Lopes, Maria Lucia Lemos, Guedes, Lissiane Karine Noronha, Miyamoto, Samira Tatiyama, Santos, Laura Caldas dos, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lúcia Euzébio, Brito, Danielle Christinne Soares Egypto de, Libório-Kimura, Tatiana Nayara, Santos, Maria Carmen Lopes Ferreira Silva, Cantali, Diego Ustárroz, Gennari, Juliana D.’Agostino, Capobianco, Karina Gatz, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha, Aline Pereira da, Rocha Filho, César Ramos, Oliveira, Fabiola Reis, and Valim, Valeria

Subjects
Clinical guidelines, Sjögren's syndrome, Gastrointestinal diseases
Abstract

Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, some systemic manifestations, mainly liver, gastrointestinal, and pancreatic are not routinely evaluated. To address these manifestations, the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology conducted a broad systematic review of the literature on studies investigating prevalence and diagnosis of these symptoms in Sjogren´s patients and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. This is the second part of this guideline, providing 6 recommendations for liver, gastrointestinal, and pancreatic care of SS patients.

Published
2022

15. Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)

Author

Trevisani, Virginia Fernandes Moça, Pugliesi, Alisson, Pasoto, Sandra Gofinet, Lopes, Maria Lucia Lemos, Guedes, Lissiane Karine Noronha, Miyamoto, Samira Tatiyama, Fernandes, Marilena Leal Mesquita Silvestre, Fialho, Sonia Cristina de Magalhães Souza, Pinheiro, Aysa César, Santos, Laura Caldas dos, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lúcia Euzébio, Brito, Danielle Christinne Soares Egypto de, Libório-Kimura, Tatiana Nayara, Santos, Maria Carmen Lopes Ferreira Silva, Cantali, Diego Ustárroz, Gennari, Juliana D’Agostino, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha-Filho, César Ramos, Oliveira, Fabiola Reis, Rocha, Aline Pereira da, and Valim, Valeria

Abstract

Sjogren’s Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, these systemic manifestations are not routinely evaluated and there is no homogenous approach to their diagnosis or evaluation. To close this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of these manifestations and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. The first part of this guideline summarizes the most important topics, and 11 recommendations are provided for the articular, pulmonary, and renal care of SS patients.

Published
2022

16. Additional file 2 of Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)

Author

Trevisani, Virginia Fernandes Moça, Pugliesi, Alisson, Pasoto, Sandra Gofinet, Lopes, Maria Lucia Lemos, Guedes, Lissiane Karine Noronha, Miyamoto, Samira Tatiyama, Fernandes, Marilena Leal Mesquita Silvestre, Fialho, Sonia Cristina de Magalhães Souza, Pinheiro, Aysa César, dos Santos, Laura Caldas, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lúcia Euzébio, de Brito, Danielle Christinne Soares Egypto, Nayara Libório-Kimura, Tatiana, Santos, Maria Carmen Lopes Ferreira Silva, Cantali, Diego Ustárroz, Gennari, Juliana D’Agostino, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha-Filho, César Ramos, Oliveira, Fabiola Reis, da Rocha, Aline Pereira, and Valim, Valeria

Abstract

Additional file 2. Joanna Briggs Institute (JBI) Critical Appraisal Checklist.

Published
2022
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17. sj-pdf-1-bmi-10.1177_11772719221131470 – Supplemental material for The Behaviour of Serum Survivin in Patients With Lupus Nephritis

Author

Lisboa, Renata Valente, de Oliveira, Fabiola Reis, Quaresma, Thaise Oliveira, de Almeida, Rafael Moura, Ribeiro Oliveira, Rene Donizeti, and Junior, Paulo Louzada

Subjects
Biochemistry
Abstract

Supplemental material, sj-pdf-1-bmi-10.1177_11772719221131470 for The Behaviour of Serum Survivin in Patients With Lupus Nephritis by Renata Valente Lisboa, Fabiola Reis de Oliveira, Thaise Oliveira Quaresma, Rafael Moura de Almeida, Rene Donizeti Ribeiro Oliveira and Paulo Louzada Junior in Biomarker Insights

Published
2022
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18. Additional file 1 of Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic)

Author

Trevisani, Virginia Fernandes Moça, Pinheiro, Aysa César, de Magalhães Souza Fialho, Sonia Cristina, Fernandes, Marilena Leal Mesquita Silvestre, Pugliesi, Alisson, Pasoto, Sandra Gofinet, Lopes, Maria Lucia Lemos, Guedes, Lissiane Karine Noronha, Miyamoto, Samira Tatiyama, dos Santos, Laura Caldas, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lúcia Euzébio, de Brito, Danielle Christinne Soares Egypto, Libório-Kimura, Tatiana Nayara, Santos, Maria Carmen Lopes Ferreira Silva, Cantali, Diego Ustárroz, Gennari, Juliana D.’Agostino, Capobianco, Karina Gatz, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, da Rocha, Aline Pereira, Rocha-Filho, César Ramos, Oliveira, Fabiola Reis, and Valim, Valeria

Abstract

Additional file 1: Search strategy/ Summary of recommendations and Joanna Briggs Institute (JBI) Critical Appraisal Checklist.

Published
2022
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19. Additional file 1 of Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)

Author

Trevisani, Virginia Fernandes Moça, Pugliesi, Alisson, Pasoto, Sandra Gofinet, Lopes, Maria Lucia Lemos, Guedes, Lissiane Karine Noronha, Miyamoto, Samira Tatiyama, Fernandes, Marilena Leal Mesquita Silvestre, Fialho, Sonia Cristina de Magalhães Souza, Pinheiro, Aysa César, dos Santos, Laura Caldas, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lúcia Euzébio, de Brito, Danielle Christinne Soares Egypto, Nayara Libório-Kimura, Tatiana, Santos, Maria Carmen Lopes Ferreira Silva, Cantali, Diego Ustárroz, Gennari, Juliana D’Agostino, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha-Filho, César Ramos, Oliveira, Fabiola Reis, da Rocha, Aline Pereira, and Valim, Valeria

Subjects
musculoskeletal diseases, urologic and male genital diseases, musculoskeletal system
Abstract

Additional file 1. Prevalence of articular, pulmonary, and renal manifestations: Descriptive summary of the studies.

Published
2022
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21. Additional file 1 of 2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome

Author

Oliveira, Fabiola Reis, Valim, Valeria, Pasoto, Sandra Gofinet, Fernandes, Marilena Leal Mesquita Silvestre, Lopes, Maria Lucia Lemos, de Magalhães Souza Fialho, Sonia Cristina, Pinheiro, Aysa César, dos Santos, Laura Caldas, Appenzeller, Simone, Fidelix, Tania, Ribeiro, Sandra Lucia Euzébio, de Brito, Danielle Christinne Soares Egypto, Libório, Tatiana, Santos, Maria Carmen Lopes Ferreira Silva, Tanure, Leandro, Gennari, Juliana DAgostino, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha-Filho, César Ramos, Miyamoto, Samira Tatiyama, Guedes, Lissiane Karine Noronha, Pugliesi, Alisson, and Trevisani, Virginia Fernandes Moça

Subjects
musculoskeletal diseases, stomatognathic diseases, stomatognathic system, eye diseases
Abstract

Additional file 1. Table 1: Gynecological symptoms in Sjogren´s syndrome patients. Table 2: Gestational outcomes in patients with Sjogren's syndrome or rheumatic diseases with reactive anti-SSA / Ro antibodies.

Published
2021
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22. Parotid gland swelling in primary Sjögren's syndrome: activity and other sialadenosis causes.

Author

Valim, Valeria, Secco, Anastasia, Oliveira, Fabiola Reis de, Vázquez, Marcos, Rosa, Bianca Barbosa, Macagnani, Fernanda Lourenço, Vargas-Bueno, Katherine Daniela, Rojas, Elías, Hernández-Delgado, Alejandra, Catalan-Pellet, Antonio, and Hernández-Molina, Gabriela

Subjects
PATIENT aftercare, PAROTITIS, CONFIDENCE intervals, SELF-evaluation, MULTIVARIATE analysis, RETROSPECTIVE studies, DIABETES, RISK assessment, HYPERLIPIDEMIA, DISEASE duration, ALCOHOL drinking, DESCRIPTIVE statistics, PAROTID glands, SJOGREN'S syndrome, BODY mass index, LOGISTIC regression analysis, ODDS ratio, LONGITUDINAL method, DISEASE risk factors, DISEASE complications
Abstract

Objective To assess the prevalence of parotid gland swelling (PGS) and its association with features of SS and other causes of sialadenosis in a Latin-American cohort of primary SS. Methods We included 668 patients from Argentina, Brazil, Mexico and Paraguay. We retrospectively registered demographics, disease duration, oral/ocular symptoms, serology and scored the basal ESSDAI. We defined PGS as a recurrent or persistent increase of volume of any parotid glands during adulthood (self-reported and/or physical examination). We registered the presence of diabetes mellitus, dyslipidaemia, body mass index and alcohol consumption. We used logistic regression analysis reporting odds ratio (OR) and 95% CI. Results PGS was present in 242 patients (36.2%): 78 previous to SS diagnosis, 86 concomitantly, 73 during follow-up and five unknown. At the multivariate analysis, PGS was associated with RF (OR 2.47, 95% CI: 1.1, 6.5, P  = 0.0001), basal articular ESSDAI domain (OR 1.63, 95% CI: 1.01, 2.6, P  = 0.04) and alcohol consumption (OR 2.42, 95% CI: 1.41, 4-15). Patients with PGS during the follow-up had a higher prevalence of alcohol consumption (45.3%) compared with the remaining PGS cases (26.8%; OR 2.41 95% CI: 1.2, 4.7), or patients without parotid gland swelling (15.6%; OR 3.8 95% CI: 1.7, 8.2) in all the adjusted models. Conclusion PGS generally precedes or presents concomitantly with SS diagnosis, and is related to RF and articular activity. Alcohol consumption is an additional factor in PGS, especially during follow-up. The meaning of this last finding as well as its prognostic implications remains to be elucidated and deserves further evaluation in prospective studies. [ABSTRACT FROM AUTHOR]

Published
2022
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23. BRAZILIAN SJOGREN'S SYNDROME REGISTRY (BRASS): A LARGE BRAZILIAN MULTICENTRIC COHORT OF PRIMARY SJOGREN'S SYNDROME

Author

VALIM, VALÉRIA, additional, MIYAMOTO, SAMIRA TATIYAMA, additional, FIDELIX, TÂNIA SALES ALENCAR, additional, LOPES, MARIA LÚCIA LEMOS, additional, PINHEIRO, AYSA CÉSAR, additional, MARKUS, JULIANA, additional, MACHADO, KETTY LYSIE LIBARDI LIRA, additional, TANURE, LEANDRO AUGUSTO, additional, OLIVEIRA, FABIOLA REIS, additional, HAX, VANESSA, additional, FEDRIGO, AIESSA ZANCHETT, additional, SAMPAIO, HENRIQUE PEREIRA, additional, PERNAMBUCO, ROBERTA ALMEIDA, additional, SERRANO, ÉRICA VIEIRA, additional, SOUSA, ANA CLÁUDIA BARBOSA, additional, ROSA, EDUARDO SOUZA, additional, APPENZELLER, SIMONE, additional, and TREVISANI, VIRGINIA FERNANDES MOÇA, additional

Published
2019
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24. SECONDARY SJOGREN'S SYNDROME TO SYSTEMIC LUPUS ERYTHEMATOSUS, SYSTEMIC SCLEROSIS AND RHEUMATOID ARTHRITIS: EVALUATION OF CLINICAL, LABORATORY AND HISTOPATHOLOGICAL PROFILE OF PATIENTS REFERRED TO A TERTIARY HOSPITAL IN BRAZIL. A 5-YEAR FOLLOW-UP.

Author

DIB, SAULO MUSSE, additional, BONJORNO, LETÍCIA PASTORELLI, additional, GIANNINI, MARCELA CAVICHIOLI, additional, JACINTO, MARCOS AFONSO CARDOZO, additional, FARIAS, MARIA EUGENIA TEIXEIRA, additional, AMARAL, NATÁLIA BRASIL, additional, GIGANTE, SAMARA LIBICH GUSMÃO, additional, MENEZES, PAMELLA INDIRA DA SILVA OLIVEIRA, additional, SILVA, ALFREDO RIBEIRO, additional, PETEAN, FLAVIO CALIL, additional, ROCHA, EDUARDO MELANI, additional, LOUZADA-JR, PAULO, additional, and OLIVEIRA, FABIOLA REIS, additional

Published
2019
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29. Epidemiology, laboratory and image profile of Sjogren's syndrome

Author

Rocha, Eduardo M., Modulo, Carolina Maria, Fragoso Motta, Ana Carolina, Barbosa, Amanda Pires, Teixeira Soto Pelinson, Anna Flora, Ribeiro-Silva, Alfredo, Garcia, Denny Marcos, Muglia, Valdair Francisco, Paulo Louzada-Junior, and Oliveira, Fabiola Reis

30. Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren's syndrome.

Author

Ying-Qian Mo, Hiroyuki Nakamura, Tsutomu Tanaka, Toshio Odani, Perez, Paola, Youngmi Ji, French, Benjamin N., Pranzatelli, Thomas J. F., Michael, Drew G., Hongen Yin, Chow, Susan S., Khalaj, Maryam, Afione, Sandra A., Changyu Zheng, Oliveira, Fabiola Reis, Motta, Ana Carolina F., Ribeiro-Silva, Alfredo, Rocha, Eduardo M., Nguyen, Cuong Q., and Masayuki Noguchi

Subjects
*SJOGREN'S syndrome, *EXOCYTOSIS, *SALIVARY glands, *MEMBRANE proteins, *EPITHELIAL cells, *PROTEINS, *CYTOKINES, *RESEARCH, *LYSOSOMES, *ANIMAL experimentation, *RESEARCH methodology, *CELL physiology, *CELL receptors, *BONE morphogenetic proteins, *RNA, *EVALUATION research, *COMPARATIVE studies, *MICE
Abstract

BMP6 is a central cytokine in the induction of Sjögren's syndrome-associated (SS-associated) secretory hypofunction. However, the upstream initiation leading to the production of this cytokine in SS is unknown. In this study, RNA ISH on salivary gland sections taken from patients with SS indicated monocytic lineage cells as a cellular source of BMP6. RNA-Seq data on human salivary glands suggested that TLR4 signaling was an upstream regulator of BMP6, which was confirmed by in vitro cell assays and single-cell transcriptomics of human PBMCs. Further investigation showed that HSP70 was an endogenous natural TLR4 ligand that stimulated BMP6 expression in SS. Release of HSP70 from epithelial cells could be triggered by overexpression of lysosome-associated membrane protein 3 (LAMP3), a protein also associated with SS in several transcriptome studies. In vitro studies supported the idea that HSP70 was released as a result of lysosomal exocytosis initiated by LAMP3 expression, and reverse transcription PCR on RNA from minor salivary glands of patients with SS confirmed a positive correlation between BMP6 and LAMP3 expression. BMP6 expression could be experimentally induced in mice by overexpression of LAMP3, which developed an SS-like phenotype. The newly identified LAMP3/HSP70/BMP6 axis provided an etiological model for SS gland dysfunction and autoimmunity. [ABSTRACT FROM AUTHOR]

Published
2022
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