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2. Ensemble Recordings in Awake Rats: Achieving Behavioral Regularity during Multimodal Stimulus Processing and Discriminative Learning

Author

Lee, Eunjeong, Oliveira-Ferreira, Ana I., and de Water,

Abstract

To meet an increasing need to examine the neurophysiological underpinnings of behavior in rats, we developed a behavioral system for studying sensory processing, attention and discrimination learning in rats while recording firing patterns of neurons in one or more brain areas of interest. Because neuronal activity is sensitive to variations in behavior which may confound the identification of neural correlates, a specific aim of the study was to allow rats to sample sensory stimuli under conditions of strong behavioral regularity. Our behavioral system allows multimodal stimulus presentation and is coupled to modules for delivering reinforcement, simultaneous monitoring of behavior and recording of ensembles of well isolated single neurons. Using training protocols for simple and compound discrimination, we validated the behavioral system with a group of 4 rats. Within these tasks, a majority of medial prefrontal neurons showed significant firing-rate changes correlated to one or more trial events that could not be explained from significant variation in head position. Thus, ensemble recordings can be combined with discriminative learning tasks under conditions of strong behavioral regularity. (Contains 9 figures.)

Published
2009
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5. Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study

Author

Dreier, Jens P., Winkler, Maren K. L., Major, Sebastian, Horst, Viktor, Lublinsky, Svetlana, Kola, Vasilis, Lemale, Coline L., Kang, Eun-Jeung, Maslarova, Anna, Salur, Irmak, Lueckl, Janos, Platz, Johannes, Jorks, Devi, Oliveira-Ferreira, Ana, I, Schoknecht, Karl, Reiffurth, Clemens, Milakara, Denny, Wiesenthal, Dirk, Hecht, Nils, Dengler, Nora F., Liotta, Agustin, Wolf, Stefan, Kowoll, Christina M., Schulte, Andre P., Santos, Edgar, Gueresir, Erdem, Unterberg, Andreas W., Sarrafzadeh, Asita, Sakowitz, Oliver W., Vatter, Hartmut, Reiner, Michael, Brinker, Gerrit, Dohmen, Christian, Shelef, Ilan, Bohner, Georg, Scheel, Michael, Vajkoczy, Peter, Hartings, Jed A., Friedman, Alon, Martus, Peter, Woitzik, Johannes, Dreier, Jens P., Winkler, Maren K. L., Major, Sebastian, Horst, Viktor, Lublinsky, Svetlana, Kola, Vasilis, Lemale, Coline L., Kang, Eun-Jeung, Maslarova, Anna, Salur, Irmak, Lueckl, Janos, Platz, Johannes, Jorks, Devi, Oliveira-Ferreira, Ana, I, Schoknecht, Karl, Reiffurth, Clemens, Milakara, Denny, Wiesenthal, Dirk, Hecht, Nils, Dengler, Nora F., Liotta, Agustin, Wolf, Stefan, Kowoll, Christina M., Schulte, Andre P., Santos, Edgar, Gueresir, Erdem, Unterberg, Andreas W., Sarrafzadeh, Asita, Sakowitz, Oliver W., Vatter, Hartmut, Reiner, Michael, Brinker, Gerrit, Dohmen, Christian, Shelef, Ilan, Bohner, Georg, Scheel, Michael, Vajkoczy, Peter, Hartings, Jed A., Friedman, Alon, Martus, Peter, and Woitzik, Johannes

Abstract

Focal brain damage after aneurysmal subarachnoid haemorrhage predominantly results from intracerebral haemorrhage, and early and delayed cerebral ischaemia. The prospective, observational, multicentre, cohort, diagnostic phase III trial, DISCHARGE-1, primarily investigated whether the peak total spreading depolarization-induced depression duration of a recording day during delayed neuromonitoring (delayed depression duration) indicates delayed ipsilateral infarction. Consecutive patients (n = 205) who required neurosurgery were enrolled in six university hospitals from September 2009 to April 2018. Subdural electrodes for electrocorticography were implanted. Participants were excluded on the basis of exclusion criteria, technical problems in data quality, missing neuroimages or patient withdrawal (n = 25). Evaluators were blinded to other measures. Longitudinal MRI, and CT studies if clinically indicated, revealed that 162/180 patients developed focal brain damage during the first 2 weeks. During 4.5 years of cumulative recording, 6777 spreading depolarizations occurred in 161/180 patients and 238 electrographic seizures in 14/180. Ten patients died early; 90/170 developed delayed infarction ipsilateral to the electrodes. Primary objective was to investigate whether a 60-min delayed depression duration cut-off in a 24-h window predicts delayed infarction with >0.60 sensitivity and >0.80 specificity, and to estimate a new cut-off. The 60-min cut-off was too short. Sensitivity was sufficient [= 0.76 (95% confidence interval: 0.65-0.84), P = 0.0014] but specificity was 0.59 (0.47-0.70), i.e. <0.80 (P < 0.0001). Nevertheless, the area under the receiver operating characteristic (AUROC) curve of delayed depression duration was 0.76 (0.69-0.83, P < 0.0001) for delayed infarction and 0.88 (0.81-0.94, P < 0.0001) for delayed ischaemia (reversible delayed neurological deficit or infarction). In secondary analysis, a new 180-min cut-off indicated delayed infarction with a tar

Published
2022

6. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Author

Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren KL, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, KC, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew IR, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn MJM, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, and Hartings, Jed A

Published
2017
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7. The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

Author

Hartings, Jed A, Shuttleworth, C William, Kirov, Sergei A, Ayata, Cenk, Hinzman, Jason M, Foreman, Brandon, Andrew, R David, Boutelle, Martyn G, Brennan, KC, Carlson, Andrew P, Dahlem, Markus A, Drenckhahn, Christoph, Dohmen, Christian, Fabricius, Martin, Farkas, Eszter, Feuerstein, Delphine, Graf, Rudolf, Helbok, Raimund, Lauritzen, Martin, Major, Sebastian, Oliveira-Ferreira, Ana I, Richter, Frank, Rosenthal, Eric S, Sakowitz, Oliver W, Sánchez-Porras, Renán, Santos, Edgar, Schöll, Michael, Strong, Anthony J, Urbach, Anja, Westover, M Brandon, Winkler, Maren KL, Witte, Otto W, Woitzik, Johannes, and Dreier, Jens P

Published
2017
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8. Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study

Author

Dreier, Jens P., primary, Winkler, Maren K. L., additional, Major, Sebastian, additional, Horst, Viktor, additional, Lublinsky, Svetlana, additional, Kola, Vasilis, additional, Lemale, Coline L., additional, Kang, Eun-Jeung, additional, Maslarova, Anna, additional, Salur, Irmak, additional, Lückl, Janos, additional, Platz, Johannes, additional, Jorks, Devi, additional, Oliveira-Ferreira, Ana I., additional, Schoknecht, Karl, additional, Reiffurth, Clemens, additional, Milakara, Denny, additional, Wiesenthal, Dirk, additional, Hecht, Nils, additional, Dengler, Nora F., additional, Liotta, Agustin, additional, Wolf, Stefan, additional, Kowoll, Christina M., additional, Schulte, André P., additional, Santos, Edgar, additional, Güresir, Erdem, additional, Unterberg, Andreas W., additional, Sarrafzadeh, Asita, additional, Sakowitz, Oliver W., additional, Vatter, Hartmut, additional, Reiner, Michael, additional, Brinker, Gerrit, additional, Dohmen, Christian, additional, Shelef, Ilan, additional, Bohner, Georg, additional, Scheel, Michael, additional, Vajkoczy, Peter, additional, Hartings, Jed A., additional, Friedman, Alon, additional, Martus, Peter, additional, and Woitzik, Johannes, additional

Published
2022
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9. sj-pdf-1-jcb-10.1177_0271678X221135085 - Supplemental material for Stroke-prone salt-sensitive spontaneously hypertensive rats show higher susceptibility to spreading depolarization (SD) and altered hemodynamic responses to SD

Author

Kang, Eun-Jeung, Prager, Ofer, Lublinsky, Svetlana, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Major, Sebastian, Müller, Dominik N, Friedman, Alon, and Dreier, Jens P

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221135085 for Stroke-prone salt-sensitive spontaneously hypertensive rats show higher susceptibility to spreading depolarization (SD) and altered hemodynamic responses to SD by Eun-Jeung Kang, Ofer Prager, Svetlana Lublinsky, Ana I Oliveira-Ferreira, Clemens Reiffurth, Sebastian Major, Dominik N Müller, Alon Friedman, Jens P Dreier in Journal of Cerebral Blood Flow & Metabolism

Published
2022
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15. The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex

Author

Lückl, Janos, primary, Lemale, Coline L, additional, Kola, Vasilis, additional, Horst, Viktor, additional, Khojasteh, Uldus, additional, Oliveira-Ferreira, Ana I, additional, Major, Sebastian, additional, Winkler, Maren K L, additional, Kang, Eun-Jeung, additional, Schoknecht, Karl, additional, Martus, Peter, additional, Hartings, Jed A, additional, Woitzik, Johannes, additional, and Dreier, Jens P, additional

Published
2018
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16. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Author

Dreier, Jens P., Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W., Shuttleworth, C. William, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J., Major, Sebastian, Winkler, Maren K. L., Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I., Reiffurth, Clemens, Revankar, Gajanan S., Sugimoto, Kazutaka, Dengler, Nora F., Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K., Piilgaard, Henning, Rosenthal, Eric S., Westover, M. Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sanchez-Porras, Renan, Jewell, Sharon L., Balanca, Baptiste, Platz, Johannes, Hinzman, Jason M., Lueckl, Janos, Schoknecht, Karl, Schoell, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S., Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P., Kowoll, Christina M., Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A., Andrew, R. David, Farkas, Eszter, Gueresir, Erdem, Vatter, Hartmut, Chung, Lee S., Brennan, K. C., Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew I. R., Sahuquillo, Juan, Dahlem, Markus A., Richter, Frank, Herreras, Oscar, Boutelle, Martyn G., Okonkwo, David O., Bullock, M. Ross, Witte, Otto W., Martus, Peter, van den Maagdenberg, Arn M. J. M., Ferrari, Michel D., Dijkhuizen, Rick M., Shutter, Lori A., Andaluz, Norberto, Schulte, Andre P., MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J., Hartings, Jed A., Dreier, Jens P., Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W., Shuttleworth, C. William, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J., Major, Sebastian, Winkler, Maren K. L., Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I., Reiffurth, Clemens, Revankar, Gajanan S., Sugimoto, Kazutaka, Dengler, Nora F., Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K., Piilgaard, Henning, Rosenthal, Eric S., Westover, M. Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sanchez-Porras, Renan, Jewell, Sharon L., Balanca, Baptiste, Platz, Johannes, Hinzman, Jason M., Lueckl, Janos, Schoknecht, Karl, Schoell, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S., Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P., Kowoll, Christina M., Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A., Andrew, R. David, Farkas, Eszter, Gueresir, Erdem, Vatter, Hartmut, Chung, Lee S., Brennan, K. C., Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew I. R., Sahuquillo, Juan, Dahlem, Markus A., Richter, Frank, Herreras, Oscar, Boutelle, Martyn G., Okonkwo, David O., Bullock, M. Ross, Witte, Otto W., Martus, Peter, van den Maagdenberg, Arn M. J. M., Ferrari, Michel D., Dijkhuizen, Rick M., Shutter, Lori A., Andaluz, Norberto, Schulte, Andre P., MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J., and Hartings, Jed A.

Abstract

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development. Spreading depolarizations are increasingly recorded during multimodal neuromonitoring in neuro-critical care as a causal biomarker providing a diagnostic summary measure of metabolic failure and excitotoxic injury. Focal ischemia causes spreading depolarization within minutes. Further spreading depolarizations arise for hours to days due to energy supply-demand mismatch in viable tissue. Spreading depolarizations exacerbate neuronal injury through prolonged ionic breakdown and spreading depolarization-related hypoperfusion (spreading ischemia). Local duration of the depolarization indicates local tissue energy status and risk of injury. Regional electrocorticographic monitoring affords even remote detection of injury because spreading depolarizations propagate widely from ischemic or metabolically stressed zones; characteristic patterns, including temporal clusters of spreading depolarizations and persistent depression of spontaneous cortical activity, can be recognized and quantified. Here, we describe the experimental basis for interpreting these patterns and illustrate their translation to human disease. We further provide consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions. These methods offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.

Published
2017

17. The continuum of spreading depolarizations in acute cortical lesion development: Examining Le(a)over-tilde-$o's legacy

Author

Hartings, Jed A., Shuttleworth, C. William, Kirov, Sergei A., Ayata, Cenk, Hinzman, Jason M., Foreman, Brandon, Andrew, R. David, Boutelle, Martyn G., Brennan, K. C., Carlson, Andrew P., Dahlem, Markus A., Drenckhahn, Christoph, Dohmen, Christian, Fabricius, Martin, Farkas, Eszter, Feuerstein, Delphine, Graf, Rudolf, Helbok, Raimund, Lauritzen, Martin, Major, Sebastian, Oliveira-Ferreira, Ana I., Richter, Frank, Rosenthal, Eric S., Sakowitz, Oliver W., Sanchez-Porras, Renan, Santos, Edgar, Scholl, Michael, Strong, Anthony J., Urbach, Anja, Westover, M. Brandon, Winkler, Maren K. L., Witte, Otto W., Woitzik, Johannes, Dreier, Jens P., Hartings, Jed A., Shuttleworth, C. William, Kirov, Sergei A., Ayata, Cenk, Hinzman, Jason M., Foreman, Brandon, Andrew, R. David, Boutelle, Martyn G., Brennan, K. C., Carlson, Andrew P., Dahlem, Markus A., Drenckhahn, Christoph, Dohmen, Christian, Fabricius, Martin, Farkas, Eszter, Feuerstein, Delphine, Graf, Rudolf, Helbok, Raimund, Lauritzen, Martin, Major, Sebastian, Oliveira-Ferreira, Ana I., Richter, Frank, Rosenthal, Eric S., Sakowitz, Oliver W., Sanchez-Porras, Renan, Santos, Edgar, Scholl, Michael, Strong, Anthony J., Urbach, Anja, Westover, M. Brandon, Winkler, Maren K. L., Witte, Otto W., Woitzik, Johannes, and Dreier, Jens P.

Abstract

A modern understanding of how cerebral cortical lesions develop after acute brain injury is based on Aristides Le (a) over tilde $o's historic discoveries of spreading depression and asphyxial/anoxic depolarization. Treated as separate entities for decades, we now appreciate that these events define a continuum of spreading mass depolarizations, a concept that is central to understanding their pathologic effects. Within minutes of acute severe ischemia, the onset of persistent depolarization triggers the breakdown of ion homeostasis and development of cytotoxic edema. These persistent changes are diagnosed as diffusion restriction in magnetic resonance imaging and define the ischemic core. In delayed lesion growth, transient spreading depolarizations arise spontaneously in the ischemic penumbra and induce further persistent depolarization and excitotoxic damage, progressively expanding the ischemic core. The causal role of these waves in lesion development has been proven by real-time monitoring of electrophysiology, blood flow, and cytotoxic edema. The spreading depolarization continuum further applies to other models of acute cortical lesions, suggesting that it is a universal principle of cortical lesion development. These pathophysiologic concepts establish a working hypothesis for translation to human disease, where complex patterns of depolarizations are observed in acute brain injury and appear to mediate and signal ongoing secondary damage.

Published
2017

18. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Author

In Vivo NMR ISI, Circulatory Health, Brain, Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren Kl, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, K C, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew Ir, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn Mjm, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, Hartings, Jed A, In Vivo NMR ISI, Circulatory Health, Brain, Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren Kl, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, K C, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew Ir, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn Mjm, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, and Hartings, Jed A

Published
2017

19. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care:Review and recommendations of the COSBID research group

Author

Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren Kl, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, K C, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew Ir, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn Mjm, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, Hartings, Jed A, Dreier, Jens P, Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W, William Shuttleworth, C, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J, Major, Sebastian, Winkler, Maren Kl, Kang, Eun-Jeung, Milakara, Denny, Oliveira-Ferreira, Ana I, Reiffurth, Clemens, Revankar, Gajanan S, Sugimoto, Kazutaka, Dengler, Nora F, Hecht, Nils, Foreman, Brandon, Feyen, Bart, Kondziella, Daniel, Friberg, Christian K, Piilgaard, Henning, Rosenthal, Eric S, Westover, M Brandon, Maslarova, Anna, Santos, Edgar, Hertle, Daniel, Sánchez-Porras, Renán, Jewell, Sharon L, Balança, Baptiste, Platz, Johannes, Hinzman, Jason M, Lückl, Janos, Schoknecht, Karl, Schöll, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S, Jahnke, Paul, Scheel, Michael, Bohner, Georg, Rostrup, Egill, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P, Kowoll, Christina M, Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A, Andrew, R David, Farkas, Eszter, Güresir, Erdem, Vatter, Hartmut, Chung, Lee S, Brennan, K C, Lieutaud, Thomas, Marinesco, Stephane, Maas, Andrew Ir, Sahuquillo, Juan, Dahlem, Markus A, Richter, Frank, Herreras, Oscar, Boutelle, Martyn G, Okonkwo, David O, Bullock, M Ross, Witte, Otto W, Martus, Peter, van den Maagdenberg, Arn Mjm, Ferrari, Michel D, Dijkhuizen, Rick M, Shutter, Lori A, Andaluz, Norberto, Schulte, André P, MacVicar, Brian, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J, and Hartings, Jed A

Abstract

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development. Spreading depolarizations are increasingly recorded during multimodal neuromonitoring in neurocritical care as a causal biomarker providing a diagnostic summary measure of metabolic failure and excitotoxic injury. Focal ischemia causes spreading depolarization within minutes. Further spreading depolarizations arise for hours to days due to energy supply-demand mismatch in viable tissue. Spreading depolarizations exacerbate neuronal injury through prolonged ionic breakdown and spreading depolarization-related hypoperfusion (spreading ischemia). Local duration of the depolarization indicates local tissue energy status and risk of injury. Regional electrocorticographic monitoring affords even remote detection of injury because spreading depolarizations propagate widely from ischemic or metabolically stressed zones; characteristic patterns, including temporal clusters of spreading depolarizations and persistent depression of spontaneous cortical activity, can be recognized and quantified. Here, we describe the experimental basis for interpreting these patterns and illustrate their translation to human disease. We further provide consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions. These methods offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.

Published
2017

20. The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

Author

Hartings, Jed A, primary, Shuttleworth, C William, additional, Kirov, Sergei A, additional, Ayata, Cenk, additional, Hinzman, Jason M, additional, Foreman, Brandon, additional, Andrew, R David, additional, Boutelle, Martyn G, additional, Brennan, KC, additional, Carlson, Andrew P, additional, Dahlem, Markus A, additional, Drenckhahn, Christoph, additional, Dohmen, Christian, additional, Fabricius, Martin, additional, Farkas, Eszter, additional, Feuerstein, Delphine, additional, Graf, Rudolf, additional, Helbok, Raimund, additional, Lauritzen, Martin, additional, Major, Sebastian, additional, Oliveira-Ferreira, Ana I, additional, Richter, Frank, additional, Rosenthal, Eric S, additional, Sakowitz, Oliver W, additional, Sánchez-Porras, Renán, additional, Santos, Edgar, additional, Schöll, Michael, additional, Strong, Anthony J, additional, Urbach, Anja, additional, Westover, M Brandon, additional, Winkler, Maren KL, additional, Witte, Otto W, additional, Woitzik, Johannes, additional, and Dreier, Jens P, additional

Published
2016
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21. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Author

Dreier, Jens P, primary, Fabricius, Martin, additional, Ayata, Cenk, additional, Sakowitz, Oliver W, additional, William Shuttleworth, C, additional, Dohmen, Christian, additional, Graf, Rudolf, additional, Vajkoczy, Peter, additional, Helbok, Raimund, additional, Suzuki, Michiyasu, additional, Schiefecker, Alois J, additional, Major, Sebastian, additional, Winkler, Maren KL, additional, Kang, Eun-Jeung, additional, Milakara, Denny, additional, Oliveira-Ferreira, Ana I, additional, Reiffurth, Clemens, additional, Revankar, Gajanan S, additional, Sugimoto, Kazutaka, additional, Dengler, Nora F, additional, Hecht, Nils, additional, Foreman, Brandon, additional, Feyen, Bart, additional, Kondziella, Daniel, additional, Friberg, Christian K, additional, Piilgaard, Henning, additional, Rosenthal, Eric S, additional, Westover, M Brandon, additional, Maslarova, Anna, additional, Santos, Edgar, additional, Hertle, Daniel, additional, Sánchez-Porras, Renán, additional, Jewell, Sharon L, additional, Balança, Baptiste, additional, Platz, Johannes, additional, Hinzman, Jason M, additional, Lückl, Janos, additional, Schoknecht, Karl, additional, Schöll, Michael, additional, Drenckhahn, Christoph, additional, Feuerstein, Delphine, additional, Eriksen, Nina, additional, Horst, Viktor, additional, Bretz, Julia S, additional, Jahnke, Paul, additional, Scheel, Michael, additional, Bohner, Georg, additional, Rostrup, Egill, additional, Pakkenberg, Bente, additional, Heinemann, Uwe, additional, Claassen, Jan, additional, Carlson, Andrew P, additional, Kowoll, Christina M, additional, Lublinsky, Svetlana, additional, Chassidim, Yoash, additional, Shelef, Ilan, additional, Friedman, Alon, additional, Brinker, Gerrit, additional, Reiner, Michael, additional, Kirov, Sergei A, additional, Andrew, R David, additional, Farkas, Eszter, additional, Güresir, Erdem, additional, Vatter, Hartmut, additional, Chung, Lee S, additional, Brennan, KC, additional, Lieutaud, Thomas, additional, Marinesco, Stephane, additional, Maas, Andrew IR, additional, Sahuquillo, Juan, additional, Dahlem, Markus A, additional, Richter, Frank, additional, Herreras, Oscar, additional, Boutelle, Martyn G, additional, Okonkwo, David O, additional, Bullock, M Ross, additional, Witte, Otto W, additional, Martus, Peter, additional, van den Maagdenberg, Arn MJM, additional, Ferrari, Michel D, additional, Dijkhuizen, Rick M, additional, Shutter, Lori A, additional, Andaluz, Norberto, additional, Schulte, André P, additional, MacVicar, Brian, additional, Watanabe, Tomas, additional, Woitzik, Johannes, additional, Lauritzen, Martin, additional, Strong, Anthony J, additional, and Hartings, Jed A, additional

Published
2016
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22. Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage

Author

Dreier, Jens P, Major, Sebastian, Manning, Andrew, Woitzik, Johannes, Drenckhahn, Chistoph, Steinbrink, Jens, Tolias, Christos, Oliveira-Ferreira, Ana I, Fabricius, Martin, Hartings, Jed A, Vajkoczy, Peter, Lauritzen, Martin, Dirnagl, Ulrich, Bohner, Georg, Strong, Anthony J, Dreier, Jens P, Major, Sebastian, Manning, Andrew, Woitzik, Johannes, Drenckhahn, Chistoph, Steinbrink, Jens, Tolias, Christos, Oliveira-Ferreira, Ana I, Fabricius, Martin, Hartings, Jed A, Vajkoczy, Peter, Lauritzen, Martin, Dirnagl, Ulrich, Bohner, Georg, and Strong, Anthony J

Abstract

Udgivelsesdato: 2009-Jul, The term cortical spreading depolarization (CSD) describes a wave of mass neuronal depolarization associated with net influx of cations and water. Clusters of prolonged CSDs were measured time-locked to progressive ischaemic damage in human cortex. CSD induces tone alterations in resistance vessels, causing either transient hyperperfusion (physiological haemodynamic response) in healthy tissue; or hypoperfusion [inverse haemodynamic response = cortical spreading ischaemia (CSI)] in tissue at risk for progressive damage, which has so far only been shown experimentally. Here, we performed a prospective, multicentre study in 13 patients with aneurysmal subarachnoid haemorrhage, using novel subdural opto-electrode technology for simultaneous laser-Doppler flowmetry (LDF) and direct current-electrocorticography, combined with measurements of tissue partial pressure of oxygen (ptiO(2)). Regional cerebral blood flow and electrocorticography were simultaneously recorded in 417 CSDs. Isolated CSDs occurred in 12 patients and were associated with either physiological, absent or inverse haemodynamic responses. Whereas the physiological haemodynamic response caused tissue hyperoxia, the inverse response led to tissue hypoxia. Clusters of prolonged CSDs were measured in five patients in close proximity to structural brain damage as assessed by neuroimaging. Clusters were associated with CSD-induced spreading hypoperfusions, which were significantly longer in duration (up to 144 min) than those of isolated CSDs. Thus, oxygen depletion caused by the inverse haemodynamic response may contribute to the establishment of clusters of prolonged CSDs and lesion progression. Combined electrocorticography and perfusion monitoring also revealed a characteristic vascular signature that might be used for non-invasive detection of CSD. Low-frequency vascular fluctuations (LF-VF) (f < 0.1 Hz), detectable by functional imaging methods, are determined by the brain's resting neuronal activity.

Published
2009

24. ENSEMBLE RECORDINGS IN A WAKE RATS: ACHIEVING BEHAVIORAL REGULARITY DURING MULTIMODAL STIMULUS PROCESSING AND DISCRIMINATIVE LEARNING.

Author

Eunjeong Lee, Oliveira-Ferreira, Ana I., de Water, Ed, Gerritsen, Hans, Bakker, Mattijs C., Kalwij, Jan A. W., van Goudoever, Tjerk, Buster, Wietze H., and Pennartz, Cyriel M. A.

Subjects
*RAT behavior, *SET theory, *BEHAVIORAL assessment, *PSYCHODIAGNOSTICS, *TASK analysis, *MATHEMATICS
Abstract

To meet an increasing need to examine the neurophysiological underpinnings of behavior in rats, we developed a behavioral system for studying sensory processing, attention and discrimination learning in rats while recording firing patterns of neurons in one or more brain areas of interest. Because neuronal activity is sensitive to variations in behavior which may confound the identification of neural correlates, a specific aim of the study was to allow rats to sample sensory stimuli under conditions of strong behavioral regularity. Our behavioral system allows multimodal stimulus presentation and is coupled to modules for delivering reinforcement, simultaneous monitoring of behavior and recording of ensembles of well isolated single neurons. Using training protocols for simple and compound discrimination, we validated the behavioral system with a group of 4 rats. Within these tasks, a majority of medial prefrontal neurons showed significant firing-rate changes correlated to one or more trial events that could not be explained from significant variation in head position. Thus, ensemble recordings can be combined with discriminative learning tasks under conditions of strong behavioral regularity. [ABSTRACT FROM AUTHOR]

Published
2009
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