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1. Diversity, host switching and evolution of Plasmodium vivax infecting African great apes

Author

Prugnolle, Franck, Rougeron, Virginie, Becquart, Pierre, Berry, Antoine, Makanga, Boris, Rahola, Nil, Arnathau, Céline, Ngoubangoye, Barthélémy, Menard, Sandie, Willaume, Eric, Ayala, Francisco J, Fontenille, Didier, Ollomo, Benjamin, Durand, Patrick, Paupy, Christophe, and Renaud, François

Subjects
Prevention, Biotechnology, Genetics, Infectious Diseases, Vaccine Related, Malaria, Rare Diseases, Clinical Research, Vector-Borne Diseases, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Adult, Animals, Central African Republic, Culicidae, DNA, Mitochondrial, Evolution, Molecular, Genetic Variation, Genome, Haplotypes, Hominidae, Host Specificity, Humans, Male, Molecular Sequence Data, Phylogeny, Plasmodium vivax, Polymerase Chain Reaction, Time Factors, emergence, transfer, malaria, sylvatic, origin
Abstract

Plasmodium vivax is considered to be absent from Central and West Africa because of the protective effect of Duffy negativity. However, there are reports of persons returning from these areas infected with this parasite and observations suggesting the existence of transmission. Among the possible explanations for this apparent paradox, the existence of a zoonotic reservoir has been proposed. May great apes be this reservoir? We analyze the mitochondrial and nuclear genetic diversity of P. vivax parasites isolated from great apes in Africa and compare it to parasites isolated from travelers returning from these regions of Africa, as well as to human isolates distributed all over the world. We show that the P. vivax sequences from parasites of great apes form a clade genetically distinct from the parasites circulating in humans. We show that this clade's parasites can be infectious to humans by describing the case of a traveler returning from the Central African Republic infected with one of them. The relationship between this P. vivax clade in great apes and the human isolates is discussed.

Published
2013

2. Multiple independent introductions of Plasmodium falciparum in South America

Author

Yalcindag, Erhan, Elguero, Eric, Arnathau, Céline, Durand, Patrick, Akiana, Jean, Anderson, Timothy J, Aubouy, Agnes, Balloux, François, Besnard, Patrick, Bogreau, Hervé, Carnevale, Pierre, D'Alessandro, Umberto, Fontenille, Didier, Gamboa, Dionicia, Jombart, Thibaut, Le Mire, Jacques, Leroy, Eric, Maestre, Amanda, Mayxay, Mayfong, Ménard, Didier, Musset, Lise, Newton, Paul N, Nkoghé, Dieudonné, Noya, Oscar, Ollomo, Benjamin, Rogier, Christophe, Veron, Vincent, Wide, Albina, Zakeri, Sedigheh, Carme, Bernard, Legrand, Eric, Chevillon, Christine, Ayala, Francisco J, Renaud, François, and Prugnolle, Franck

Subjects
Malaria, Rare Diseases, Genetics, Vector-Borne Diseases, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Bayes Theorem, Cluster Analysis, Demography, Emigration and Immigration, Genetic Variation, Genetics, Population, Humans, Logistic Models, Microsatellite Repeats, Models, Genetic, Phylogeny, Phylogeography, Plasmodium falciparum, Polymorphism, Single Nucleotide, Principal Component Analysis, South America, malaria origin, New World, human migrations, genetic diversity
Abstract

The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence--archeological and genetic--suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade.

Published
2012

4. African monkeys are infected by Plasmodium falciparum nonhuman primate-specific strains

Author

Prugnolle, Franck, Ollomo, Benjamin, Durand, Patrick, Yalcindag, Erhan, Arnathau, Céline, Elguero, Eric, Berry, Antoine, Pourrut, Xavier, Gonzalez, Jean-Paul, Nkoghe, Dieudonné, Akiana, Jean, Verrier, Delphine, Leroy, Eric, Ayala, Francisco J, and Renaud, François

Subjects
Infectious Diseases, Vector-Borne Diseases, HIV/AIDS, Malaria, Rare Diseases, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Animals, Base Sequence, Cercopithecidae, DNA Primers, Fluorescence Resonance Energy Transfer, Gabon, Likelihood Functions, Malaria, Falciparum, Microsatellite Repeats, Models, Genetic, Molecular Sequence Data, Monkey Diseases, Multidrug Resistance-Associated Proteins, Mutation, Phylogeny, Plasmodium falciparum, Polymorphism, Single Nucleotide, Principal Component Analysis, Sequence Analysis, DNA, Species Specificity, human malaria, laverania clade, parasite host transfer, cytochrome b, biological evolution
Abstract

Recent molecular exploration of the Plasmodium species circulating in great apes in Africa has revealed the existence of a large and previously unknown diversity of Plasmodium. For instance, gorillas were found to be infected by parasites closely related to Plasmodium falciparum, suggesting that the human malignant malaria agent may have arisen after a transfer from gorillas. Although this scenario is likely in light of the data collected in great apes, it remained to be ascertained whether P. falciparum-related parasites may infect other nonhuman primates in Africa. Using molecular tools, we here explore the diversity of Plasmodium species infecting monkeys in Central Africa. In addition to previously described Hepatocystis and Plasmodium species (Plasmodium gonderi and Plasmodium sp DAJ-2004), we have found one African monkey to be infected by a P. falciparum-related parasite. Examination of the nuclear and mitochondrial genomes of this parasite reveals that it is specific of nonhuman primates, indicating that P. falciparum-related pathogens can naturally circulate in some monkey populations in Africa. We also show that at least two distinct genetic entities of P. falciparum infect nonhuman primates and humans, respectively. Our discoveries bring into question the proposed gorilla origin of human P. falciparum.

Published
2011

5. Plasmodium falciparum is not as lonely as previously considered

Author

Prugnolle, Franck, Ayala, Francisco, Ollomo, Benjamin, Arnathau, Céline, Durand, Patrick, and Renaud, François

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Vector-Borne Diseases, Orphan Drug, Infectious Diseases, Malaria, Rare Diseases, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Animals, Evolution, Molecular, Humans, Molecular Sequence Data, Phylogeny, Plasmodium, Plasmodium falciparum, Primate Diseases, Laverania, Great apes, diversity, origin, speciation, virulence, Ecological Applications, Microbiology, Medical microbiology
Abstract

Until very recently, only one species (P. reichenowi) was known to be a phylogenetic sister lineage of P. falciparum, the main malignant agent of human malaria. In 2009 and 2010, new studies have revealed the existence of several new phylogenetic species related to this deadly parasite and infecting chimpanzees and gorillas in Africa. These discoveries invite us to explore a whole set of new questions, which we briefly do in this article.

Published
2011

6. African great apes are natural hosts of multiple related malaria species, including Plasmodium falciparum

Author

Prugnolle, Franck, Durand, Patrick, Neel, Cécile, Ollomo, Benjamin, Ayala, Francisco J, Arnathau, Céline, Etienne, Lucie, Mpoudi-Ngole, Eitel, Nkoghe, Dieudonné, Leroy, Eric, Delaporte, Eric, Peeters, Martine, and Renaud, François

Subjects
Vector-Borne Diseases, Malaria, Rare Diseases, Infectious Diseases, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Animals, Cameroon, Feces, Gabon, Gorilla gorilla, Host-Parasite Interactions, Humans, Pan troglodytes, Phylogeny, Plasmodium, Plasmodium falciparum, cytochrome b gene, ecology, evolution, host specificity, infectious diseases
Abstract

Plasmodium reichenowi, a chimpanzee parasite, was until very recently the only known close relative of Plasmodium falciparum, the most virulent agent of human malaria. Recently, Plasmodium gaboni, another closely related chimpanzee parasite, was discovered, suggesting that the diversity of Plasmodium circulating in great apes in Africa might have been underestimated. It was also recently shown that P. reichenowi is a geographically widespread and genetically diverse chimpanzee parasite and that the world diversity of P. falciparum is fully included within the much broader genetic diversity of P. reichenowi. The evidence indicates that all extant populations of P. falciparum originated from P. reichenowi, likely by a single transfer from chimpanzees. In this work, we have studied the diversity of Plasmodium species infecting chimpanzees and gorillas in Central Africa (Cameroon and Gabon) from both wild-living and captive animals. The studies in wild apes used noninvasive sampling methods. We confirm the presence of P. reichenowi and P. gaboni in wild chimpanzees. Moreover, our results reveal the existence of an unexpected genetic diversity of Plasmodium lineages circulating in gorillas. We show that gorillas are naturally infected by two related lineages of parasites that have not been described previously, herein referred to as Plasmodium GorA and P. GorB, but also by P. falciparum, a species previously considered as strictly human specific. The continuously increasing contacts between humans and primate populations raise concerns about further reciprocal host transfers of these pathogens.

Published
2010

8. Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria

Author

Otto, Thomas D., Gilabert, Aude, Crellen, Thomas, Böhme, Ulrike, Arnathau, Céline, Sanders, Mandy, Oyola, Samuel O., Okouga, Alain Prince, Boundenga, Larson, Willaume, Eric, Ngoubangoye, Barthélémy, Moukodoum, Nancy Diamella, Paupy, Christophe, Durand, Patrick, Rougeron, Virginie, Ollomo, Benjamin, Renaud, François, Newbold, Chris, Berriman, Matthew, and Prugnolle, Franck

Published
2018
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9. The host specificity of ape malaria parasites can be broken in confined environments

Author

Ngoubangoye, Barthélémy, Boundenga, Larson, Arnathau, Céline, Mombo, Illich Manfred, Durand, Patrick, Tsoumbou, Thierry-Audrey, Otoro, Bertony Vacky, Sana, Rick, Okouga, Alain-Prince, Moukodoum, Nancy, Willaume, Eric, Herbert, Anaïs, Fouchet, David, Rougeron, Virginie, Bâ, Cheikh Tidiane, Ollomo, Benjamin, Paupy, Christophe, Leroy, Eric M., Renaud, François, Pontier, Dominique, and Prugnolle, Franck

Published
2016
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10. Ape malaria transmission and potential for ape-to-human transfers in Africa

Author

Makanga, Boris, Yangari, Patrick, Rahola, Nil, Rougeron, Virginie, Elguero, Eric, Boundenga, Larson, Moukodoum, Nancy Diamella, Okouga, Alain Prince, Arnathau, Céline, Durand, Patrick, Willaume, Eric, Ayala, Diego, Fontenille, Didier, Ayala, Francisco J., Renaud, François, Ollomo, Benjamin, Prugnolle, Franck, and Paupy, Christophe

Published
2016

11. Malaria continues to select for sickle cell trait in Central Africa

Author

Elguero, Eric, Délicat-Loembet, Lucrèce M., Rougeron, Virginie, Arnathau, Céline, Roche, Benjamin, Becquart, Pierre, Gonzalez, Jean-Paul, Nkoghe, Dieudonné, Sica, Lucas, Leroy, Eric M., Durand, Patrick, Ayala, Francisco J., Ollomo, Benjamin, Renaud, François, and Prugnolle, Franck

Published
2015

12. Author Correction: Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria

Author

Otto, Thomas D., Gilabert, Aude, Crellen, Thomas, Böhme, Ulrike, Arnathau, Céline, Sanders, Mandy, Oyola, Samuel O., Okouga, Alain Prince, Boundenga, Larson, Willaume, Eric, Ngoubangoye, Barthélémy, Moukodoum, Nancy Diamella, Paupy, Christophe, Durand, Patrick, Rougeron, Virginie, Ollomo, Benjamin, Renaud, François, Newbold, Chris, Berriman, Matthew, and Prugnolle, Franck

Published
2020
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15. Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

Author

Rutledge, Gavin G., Böhme, Ulrike, Sanders, Mandy, Reid, Adam J., Cotton, James A., Maiga-Ascofare, Oumou, Djimdé, Abdoulaye A., Apinjoh, Tobias O., Amenga-Etego, Lucas, Manske, Magnus, Barnwell, John W., Renaud, François, Ollomo, Benjamin, Prugnolle, Franck, Anstey, Nicholas M., Auburn, Sarah, Price, Ric N., McCarthy, James S., Kwiatkowski, Dominic P., Newbold, Chris I., Berriman, Matthew, and Otto, Thomas D.

Published
2017
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16. Prevalence and factors associated to gestational diabetes mellitus among pregnant women in Libreville: a cross-sectional study

Author

Lendoye, Elisabeth, primary, Ngoungou, Edgard Brice, additional, Komba, Opheelia Makoyo, additional, Ollomo, Benjamin, additional, N’negue-Mezui, Marie-Andrée, additional, Bekale, Serge, additional, Yacka-Mouele, Lauriane, additional, Obiang Obounou, Brice Wilfried, additional, Ntyonga-Pono, Marie-Pierrette, additional, and Ngou-Milama, Edouard, additional

Published
2022
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17. Molecular identification of trypanosome species in trypanotolerant cattle from the south of Gabon

Author

Maganga Gaël Darren, Mavoungou Jacques-François, N’dilimabaka Nadine, Moussadji Kinga Ivan Cyr, Mvé-Ondo Bertrand, Mombo Illich Manfred, Ngoubangoye Barthélémy, Cossic Brieuc, Mikala Okouyi Clency Sylde, Souza Alain, Leroy Eric Maurice, Kumulungui Brice, and Ollomo Benjamin

Subjects
Trypanosoma congolense, Trypanosoma vivax, Trypanotolerant cattle, ITS1 PCR, Infectious and parasitic diseases, RC109-216
Abstract

The aim of this study was to provide information on trypanosome species infecting trypanotolerant cattle from southern Gabon. The study was conducted on 224 trypanotolerant cattle from three regions located in southern Gabon, using ITS1 primer-based PCR. Seventy-two (32%) N’dama cattle were found polymerase chain reaction (PCR) positive with trypanosomes. The overall prevalence of trypanosomosis was 57% (63/110), 4% (4/100), and 36% (5/14) in the Gala section of the Nyanga ranch, the Miyama ranch, and Ossiele, respectively. Trypanosoma congolense and Trypanosoma vivax were identified. In Gala section and Ossiele, T. congolense and T. vivax were found. In the Miyama ranch, only T. vivax was identified. Mixed infections were also found. The forest (9%) and savannah (63%) subgroups of T. congolense were identified. The presence of the two subgroups was detected in 16 out of 56 cattle (29%). T. congolense and T. vivax would appear to be the main agents responsible for bovine trypanosomosis in southern Gabon. Although trypanotolerant, N’dama cattle may serve as a reservoir, and this should be further studied. On the other hand, these trypanotolerant cattle can be reared in such tsetse infested areas, which gives them an advantage compared to other trypanosensitive breeds, and this shows that they represent a key factor in biodiversity which has to be promoted.

Published
2017
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18. Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3

Author

Daubersies, Pierre, Thomas, Alan W., Millet, Pascal, Brahimi, Karima, Langermans, Jan A.M., Ollomo, Benjamin, BenMohamed, Lbachir, Slierendregt, Bas, Eling, Wijnand, Van Belkum, Alex, Dubreuil, Guy, Meis, Jacques F.G.M., Guérin-Marchand, Claudine, Cayphas, Sylvie, Cohen, Joe, Gras-Masse, Hélène, and Druilhe, Pierre

Published
2000
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19. Concurrent chikungunya and dengue virus infections during simultaneous outbreaks, Gabon, 2007

Author

Leroy, Eric M., Nkoghe, Dieudone, Ollomo, Benjamin, Nze-Nkogue, Chimene, Becquart, Pierre, Grard, Gilda, Pourrut, Xavier, Charrel, Remi, Moureau, Gregory, Ndjoyi-Mbiguino, Angelique, and De Lamballerie, Xavier

Subjects
Distribution, Research, Company distribution practices, Chikungunya fever -- Distribution -- Research, Disease transmission -- Research, Dengue fever -- Distribution -- Research, Dengue -- Distribution -- Research
Abstract

In the past 20 years, dengue virus (DENV) and chikungunya virus (CHIKV) have caused large and geographically wide ranging epidemics (1,2). Recent CHIKV outbreaks caused several million clinical cases in [...]

Published
2009

20. Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution

Author

Gilabert, Aude, primary, Otto, Thomas D., additional, Rutledge, Gavin G., additional, Franzon, Blaise, additional, Ollomo, Benjamin, additional, Arnathau, Céline, additional, Durand, Patrick, additional, Moukodoum, Nancy D., additional, Okouga, Alain-Prince, additional, Ngoubangoye, Barthélémy, additional, Makanga, Boris, additional, Boundenga, Larson, additional, Paupy, Christophe, additional, Renaud, François, additional, Prugnolle, Franck, additional, and Rougeron, Virginie, additional

Published
2018
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21. Use of geographic indicators of healthcare, environment and socioeconomic factors to characterize environmental health disparities

Author

Padilla, Cindy, Kihal-Talantikit, Wahida, Perez, Sandra, Wahida, Kihal-Talantikite, Denis, Zmirou-Navier, Olivier, Blanchard, Géraldine, Le, Quénel, Philippe, Deguen, Séverine, Dixon, P, Sheridan, Scott, Vieira, Verónica, Jeanjean, Maxime, Wahida, Kihal, Chen, Kai-Chieh, Kihal-Talantikite, Wahida, Siebert, Muriel, Couchoud, Cécile, Vigneau, Cécile, Bayat, Sahar, Rossello, Philippe, Le Nir, Geraldine, Zmirou-Navier, Denis, Nkoghé, Dieudonné, Becquart, Pierre, Wauquier, Nadia, Moussavou, Ghislain, Akué, Jean, Ollomo, Benjamin, Pourrut, Xavier, Souris, Marc, Kazanji, Mirdad, Gonzalez, Jean-Paul, Leroy, Eric, Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), École des Hautes Études en Santé Publique [EHESP] (EHESP), Études des Structures, des Processus d’Adaptation et des Changements de l’Espace (ESPACE), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), City of Nice Financial support as a post-doctoral grant, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Département Méthodes quantitatives en santé publique (METIS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Avignon Université (AU)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Environmental Health, Boston University [Boston] (BU), Laboratoire Image, Ville, Environnement (LIVE), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Service de néphrologie, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Registre REIN, Agence de la biomédecine [Saint-Denis la Plaine], Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Pôle métier Climat & Air du CRIGE-PACA, GeographR, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Ministère de la Santé, Ministère de la santé, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Metabiota Inc, San Francisco, Centre International de Recherche médicale de Franceville, Centre International de Recherche Médicale de Franceville, Centre International de Recherches Médicales de Franceville (CIRMF), Centre International de Recherches Médicales de Franceville, Conditions et territoires d'émergence des maladies : dynamiques spatio-temporelles de l'émergence, évolution, diffusion/réduction des maladies, résistance et prémunition des hôtes (CTEM), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Service archéologique de la ville de Lyon, Mairie de Lyon, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Perez, Sandra, and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Avignon Université (AU)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
neonatal mortality, spatial analysis, • Environmental exposures, • Socioeconomic, Health, Toxicology and Mutagenesis, [SHS.GEO] Humanities and Social Sciences/Geography, Air pollution, Environment, Infant mortality, Generalized additive models, Health Services Accessibility, fine geographic scale, • Deprivation, Spatial-temporal analysis, spatial modeling, neighbourhood deprivation, Humans, residential mobility, Cities, Social determinants, Healthcare accessibility, Environmental inequalities, Health inequalities, long-term, Research, Environmental health inequalities, Public Health, Environmental and Occupational Health, Infant, Newborn, • Congenital abnormalities, Infant, neighborhood deprivation, Health Status Disparities, [SHS.GEO]Humanities and Social Sciences/Geography, GIS, environmental nuisances, • Air pollution, ESRD incidence, Socioeconomic Factors, GIS & Spatial Analyses, fine spatial scale, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, Female, France, cumulative exposure assessment, Environmental Health, cluster analysis
Abstract

International audience; Background: An environmental health inequality is a major public health concern in Europe. However just few studies take into account a large set of characteristics to analyze this problematic. The aim of this study was to identify and describe how socioeconomic, health accessibility and exposure factors accumulate and interact in small areas in a French urban context, to assess environmental health inequalities related to infant and neonatal mortality.Methods: Environmental indicators on deprivation index, proximity to high-traffic roads, green space, and healthcare accessibility were created using the Geographical Information System. Cases were collected from death certificates in the city hall of each municipality in the Nice metropolitan area. Using the parental addresses, cases were geocoded to their census block of residence. A classification using a Multiple Component Analysis following by a Hierarchical Clustering allow us to characterize the census blocks in terms of level of socioeconomic, environmental and accessibility to healthcare, which are very diverse definition by nature. Relation between infant and neonatal mortality rate and the three environmental patterns which categorize the census blocks after the classification was performed using a standard Poisson regression model for count data after checking the assumption of dispersion.Results: Based on geographic indicators, three environmental patterns were identified. We found environmental inequalities and social health inequalities in Nice metropolitan area. Moreover these inequalities are counterbalance by the close proximity of deprived census blocks to healthcare facilities related to mother and newborn. So therefore we demonstrate no environmental health inequalities related to infant and neonatal mortality.Conclusion: Examination of patterns of social, environmental and in relation with healthcare access is useful to identify census blocks with needs and their effects on health. Similar analyzes could be implemented and considered in other cities or related to other birth outcomes.

Published
2016
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22. Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution

Author

Gilabert, Aude, primary, Otto, Thomas D., additional, Rutledge, Gavin G., additional, Franzon, Blaise, additional, Ollomo, Benjamin, additional, Arnathau, Céline, additional, Durand, Patrick, additional, Moukodoum, Nancy D., additional, Okouga, Alain-Prince, additional, Ngoubangoye, Barthélémy, additional, Makanga, Boris, additional, Boudenga, Larson, additional, Paupy, Christophe, additional, Renaud, François, additional, Prugnolle, Frank, additional, and Rougeron, Virginie, additional

Published
2017
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23. Tracking zoonotic pathogens using blood-sucking flies as 'flying syringes'

Author

Bitome-Essono, Paul-Yannick, primary, Ollomo, Benjamin, additional, Arnathau, Céline, additional, Durand, Patrick, additional, Mokoudoum, Nancy Diamella, additional, Yacka-Mouele, Lauriane, additional, Okouga, Alain-Prince, additional, Boundenga, Larson, additional, Mve-Ondo, Bertrand, additional, Obame-Nkoghe, Judicaël, additional, Mbehang-Nguema, Philippe, additional, Njiokou, Flobert, additional, Makanga, Boris, additional, Wattier, Rémi, additional, Ayala, Diego, additional, Ayala, Francisco J, additional, Renaud, Francois, additional, Rougeron, Virginie, additional, Bretagnolle, Francois, additional, Prugnolle, Franck, additional, and Paupy, Christophe, additional

Published
2017
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24. African Non-Human Primates Host Diverse Enteroviruses

Author

Mombo, Illich Manfred, Lukashev, Alexander N., Bleicker, Tobias, Bruenink, Sebastian, Berthet, Nicolas, Maganga, Gael D., Durand, Patrick, Arnathau, Celine, Boundenga, Larson, Ngoubangoye, Barthelemy, Boue, Vanina, Liegeois, Florian, Ollomo, Benjamin, Prugnolle, Franck, Drexler, Jan Felix, Drosten, Christian, Renaud, Francois, Rougeron, Virginie, Leroy, Eric, Mombo, Illich Manfred, Lukashev, Alexander N., Bleicker, Tobias, Bruenink, Sebastian, Berthet, Nicolas, Maganga, Gael D., Durand, Patrick, Arnathau, Celine, Boundenga, Larson, Ngoubangoye, Barthelemy, Boue, Vanina, Liegeois, Florian, Ollomo, Benjamin, Prugnolle, Franck, Drexler, Jan Felix, Drosten, Christian, Renaud, Francois, Rougeron, Virginie, and Leroy, Eric

Abstract

Enteroviruses (EVs) belong to the family Picornaviridae and are responsible for mild to severe diseases in mammals including humans and non-human primates (NHP). Simian EVs were first discovered in the 1950s in the Old World Monkeys and recently in wild chimpanzee, gorilla and mandrill in Cameroon. In the present study, we screened by PCR EVs in 600 fecal samples of wild apes and monkeys that were collected at four sites in Gabon. A total of 32 samples were positive for EVs (25 from mandrills, 7 from chimpanzees, none from gorillas). The phylogenetic analysis of VP1 and VP2 genes showed that EVs identified in chimpanzees were members of two human EV species, EV-A and EV-B, and those identified in mandrills were members of the human species EV-B and the simian species EV-J. The identification of two novel enterovirus types, EV-B112 in a chimpanzee and EV-B113 in a mandrill, suggests these NHPs could be potential sources of new EV types. The identification of EV-B107 and EV90 that were previously found in humans indicates cross-species transfers. Also the identification of chimpanzee-derived EV110 in a mandrill demonstrated a wide host range of this EV. Further research of EVs in NHPs would help understanding emergence of new types or variants, and evaluating the real risk of cross-species transmission for humans as well for NHPs populations.

Published
2017

25. Additional file 1: of Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon

Author

Mvé-Ondo, Bertrand, Nkoghe, Dieudonné, Arnathau, Céline, Rougeron, Virginie, Bisvigou, Ulrich, Mouele, Lauriane, Larson Boundenga, Durand, Patrick, Elguero, Eric, Lemmers, Simone, Délicat-Loembet, Lucrèce, Diamella-Moukodoum, Nancy, Paupy, Christophe, Renaud, François, Prugnolle, Franck, and Ollomo, Benjamin

Subjects
parasitic diseases
Abstract

Sequences of primers used for genotyping P. falciparum genes. This table shows the primers sequences (cytochrome b, MSP1, MSP2, EBA 175 and GLURP) used.

Published
2015
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26. Additional file 3: of Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon

Author

Mvé-Ondo, Bertrand, Nkoghe, Dieudonné, Arnathau, Céline, Rougeron, Virginie, Bisvigou, Ulrich, Mouele, Lauriane, Larson Boundenga, Durand, Patrick, Elguero, Eric, Lemmers, Simone, Délicat-Loembet, Lucrèce, Diamella-Moukodoum, Nancy, Paupy, Christophe, Renaud, François, Prugnolle, Franck, and Ollomo, Benjamin

Abstract

Allelic diversity of MSP-1, MSP-2, EBA-175 and Glurp of P. falciparum in Bantus and Baka Pygmies. Distribution of alleles of genes MSP1, MSP2, EBA 175 and GLUPR by Population Group.

Published
2015
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27. Additional file 4: of Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon

Author

Mvé-Ondo, Bertrand, Nkoghe, Dieudonné, Arnathau, Céline, Rougeron, Virginie, Bisvigou, Ulrich, Mouele, Lauriane, Larson Boundenga, Durand, Patrick, Elguero, Eric, Lemmers, Simone, Délicat-Loembet, Lucrèce, Diamella-Moukodoum, Nancy, Paupy, Christophe, Renaud, François, Prugnolle, Franck, and Ollomo, Benjamin

Abstract

Pairwise F ST estimates (θ) measured between each pair of populations for each of the four candidate genes (MSP2, MSP1, EBA-175, GLURP). Values in bold are F ST values obtained within mixed villages between P. falciparum from Pygmies and Bantus. *P-value

Published
2015
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28. Additional file 2: of Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon

Author

Mvé-Ondo, Bertrand, Nkoghe, Dieudonné, Arnathau, Céline, Rougeron, Virginie, Bisvigou, Ulrich, Mouele, Lauriane, Larson Boundenga, Durand, Patrick, Elguero, Eric, Lemmers, Simone, Délicat-Loembet, Lucrèce, Diamella-Moukodoum, Nancy, Paupy, Christophe, Renaud, François, Prugnolle, Franck, and Ollomo, Benjamin

Subjects
parasitic diseases
Abstract

Microsatellite loci characteristics for P. falciparum. Presentation of the seven microsatellite sequences used and their repeat motif.

Published
2015
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29. Author response: Tracking zoonotic pathogens using blood-sucking flies as 'flying syringes'

Author

Bitome-Essono, Paul-Yannick, primary, Ollomo, Benjamin, additional, Arnathau, Céline, additional, Durand, Patrick, additional, Mokoudoum, Nancy Diamella, additional, Yacka-Mouele, Lauriane, additional, Okouga, Alain-Prince, additional, Boundenga, Larson, additional, Mve-Ondo, Bertrand, additional, Obame-Nkoghe, Judicaël, additional, Mbehang-Nguema, Philippe, additional, Njiokou, Flobert, additional, Makanga, Boris, additional, Wattier, Rémi, additional, Ayala, Diego, additional, Ayala, Francisco J, additional, Renaud, Francois, additional, Rougeron, Virginie, additional, Bretagnolle, Francois, additional, Prugnolle, Franck, additional, and Paupy, Christophe, additional

Published
2017
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30. African Non-Human Primates Host Diverse Enteroviruses

Author

Mombo, Illich Manfred, primary, Lukashev, Alexander N., additional, Bleicker, Tobias, additional, Brünink, Sebastian, additional, Berthet, Nicolas, additional, Maganga, Gael D., additional, Durand, Patrick, additional, Arnathau, Céline, additional, Boundenga, Larson, additional, Ngoubangoye, Barthélémy, additional, Boué, Vanina, additional, Liégeois, Florian, additional, Ollomo, Benjamin, additional, Prugnolle, Franck, additional, Drexler, Jan Felix, additional, Drosten, Christian, additional, Renaud, François, additional, Rougeron, Virginie, additional, and Leroy, Eric, additional

Published
2017
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31. Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria

Author

Otto, Thomas D., primary, Gilabert, Aude, additional, Crellen, Thomas, additional, Böhme, Ulrike, additional, Arnathau, Céline, additional, Sanders, Mandy, additional, Oyola, Samuel, additional, Okouga, Alain Prince, additional, Boundenga, Larson, additional, Willaume, Eric, additional, Ngoubangoye, Barthélémy, additional, Moukodoum, Nancy Diamella, additional, Paupy, Christophe, additional, Durand, Patrick, additional, Rougeron, Virginie, additional, Ollomo, Benjamin, additional, Renaud, François, additional, Newbold, Chris, additional, Berriman, Matthew, additional, and Prugnolle, Franck, additional

Published
2016
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32. ElusivePlasmodiumSpecies Complete the Human Malaria Genome Set

Author

Rutledge, Gavin G., primary, Böehme, Ulrike, additional, Sanders, Mandy, additional, Reid, Adam J., additional, Maiga-Ascofare, Oumou, additional, Djimdé, Abdoulaye A., additional, Apinjoh, Tobias O., additional, Amenga-Etego, Lucas, additional, Manske, Magnus, additional, Barnwell, John W., additional, Renaud, François, additional, Ollomo, Benjamin, additional, Prugnolle, Franck, additional, Anstey, Nicholas M., additional, Auburn, Sarah, additional, Price, Ric N., additional, McCarthy, James S., additional, Kwiatkowski, Dominic P., additional, Newbold, Chris I., additional, Berriman, Matthew, additional, and Otto, Thomas D., additional

Published
2016
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33. Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa

Author

Boundenga, Larson, primary, Makanga, Boris, additional, Ollomo, Benjamin, additional, Gilabert, Aude, additional, Rougeron, Virginie, additional, Mve-Ondo, Bertrand, additional, Arnathau, Céline, additional, Durand, Patrick, additional, Moukodoum, Nancy Diamella, additional, Okouga, Alain-Prince, additional, Delicat-Loembet, Lucresse, additional, Yacka-Mouele, Lauriane, additional, Rahola, Nil, additional, Leroy, Eric, additional, BA, Cheikh Tidiane, additional, Renaud, Francois, additional, Prugnolle, Franck, additional, and Paupy, Christophe, additional

Published
2016
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34. Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon

Author

Mvé-Ondo, Bertrand, primary, Nkoghe, Dieudonné, additional, Arnathau, Céline, additional, Rougeron, Virginie, additional, Bisvigou, Ulrich, additional, Mouele, Lauriane Yacka, additional, Boundenga, Larson, additional, Durand, Patrick, additional, Elguero, Eric, additional, Lemmers, Simone, additional, Délicat-Loembet, Lucrèce M., additional, Diamella-Moukodoum, Nancy, additional, Paupy, Christophe, additional, Renaud, François, additional, Prugnolle, Franck, additional, and Ollomo, Benjamin, additional

Published
2015
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35. High Rate of Simian Immunodeficiency Virus (SIV) Infections in Wild Chimpanzees in Northeastern Gabon

Author

Boué, Vanina, primary, Locatelli, Sabrina, additional, Boucher, Floriane, additional, Ayouba, Ahidjo, additional, Butel, Christelle, additional, Esteban, Amandine, additional, Okouga, Alain-Prince, additional, Ndoungouet, Alphonse, additional, Motsch, Peggy, additional, Flohic, Guillaume, additional, Ngari, Paul, additional, Prugnolle, Franck, additional, Ollomo, Benjamin, additional, Rouet, François, additional, and Liégeois, Florian, additional

Published
2015
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36. No Evidence for Ape Plasmodium Infections in Humans in Gabon

Author

Délicat-Loembet, Lucresse, primary, Rougeron, Virginie, additional, Ollomo, Benjamin, additional, Arnathau, Céline, additional, Roche, Benjamin, additional, Elguero, Eric, additional, Moukodoum, Nancy Diamella, additional, Okougha, Alain-Prince, additional, Mve Ondo, Bertrand, additional, Boundenga, Larson, additional, Houzé, Sandrine, additional, Galan, Maxime, additional, Nkoghé, Dieudonné, additional, Leroy, Eric M., additional, Durand, Patrick, additional, Paupy, Christophe, additional, Renaud, François, additional, and Prugnolle, Franck, additional

Published
2015
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37. Malaria-like symptoms associated with a natural Plasmodium reichenowi infection in a chimpanzee

Author

Herbert, Anaïs, primary, Boundenga, Larson, additional, Meyer, Anne, additional, Moukodoum, Diamella Nancy, additional, Okouga, Alain Prince, additional, Arnathau, Céline, additional, Durand, Patrick, additional, Magnus, Julie, additional, Ngoubangoye, Barthélémy, additional, Willaume, Eric, additional, Ba, Cheikh Tidiane, additional, Rougeron, Virginie, additional, Renaud, François, additional, Ollomo, Benjamin, additional, and Prugnolle, Franck, additional

Published
2015
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38. Diversity of malaria parasites in great apes in Gabon

Author

Boundenga, Larson, primary, Ollomo, Benjamin, additional, Rougeron, Virginie, additional, Mouele, Lauriane Yacka, additional, Mve-Ondo, Bertrand, additional, Delicat-Loembet, Lucrèce M, additional, Moukodoum, Nancy Diamella, additional, Okouga, Alain Prince, additional, Arnathau, Céline, additional, Elguero, Eric, additional, Durand, Patrick, additional, Liégeois, Florian, additional, Boué, Vanina, additional, Motsch, Peggy, additional, Le Flohic, Guillaume, additional, Ndoungouet, Alphonse, additional, Paupy, Christophe, additional, Ba, Cheikh Tidiane, additional, Renaud, Francois, additional, and Prugnolle, Franck, additional

Published
2015
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39. Relation entre hépatite C ou B et infection à P. falciparum dans une zone hyperendémique de transmission palustre au Gabon

Author

Ouwe-Missi-Oukem-Boyer, Odile, Toure, FS, Ollomo, Benjamin, Mezui-Me-Ndong, Jérome, Lachard, Isabelle, Ndong-Atome, Guy-Roger, Makuwa, Maria, Roques, Pierre, Branger, M., Preux, Pierre-Marie, Mazier, D, Bisser, Sylvie, Centre international de référence Chantal Biya pour la recherche sur la prévention et la prise en charge du VIH/SIDA (CIRCB), Fondation Chantal Biya (FCB), Centre International de Recherches Médicales de Franceville (CIRMF), Unité de Rétrovirologie, Institut des Maladies Emergentes et des Thérapies Innovantes (IMETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Grelier, Elisabeth, and Université de Limoges (UNILIM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)

Subjects
[SDV] Life Sciences [q-bio], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV]Life Sciences [q-bio], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

40. Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts

Author

Otto, Thomas D., primary, Rayner, Julian C., additional, Böhme, Ulrike, additional, Pain, Arnab, additional, Spottiswoode, Natasha, additional, Sanders, Mandy, additional, Quail, Michael, additional, Ollomo, Benjamin, additional, Renaud, François, additional, Thomas, Alan W., additional, Prugnolle, Franck, additional, Conway, David J., additional, Newbold, Chris, additional, and Berriman, Matthew, additional

Published
2014
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41. Prevalence of the Sickle Cell Trait in Gabon: A nationwide study

Author

Délicat-Loembet, Lucrèce M., primary, Elguero, Eric, additional, Arnathau, Céline, additional, Durand, Patrick, additional, Ollomo, Benjamin, additional, Ossari, Simon, additional, Mezui-me-ndong, Jérôme, additional, Mbang Mboro, Thélesfort, additional, Becquart, Pierre, additional, Nkoghe, Dieudonné, additional, Leroy, Eric, additional, Sica, Lucas, additional, Gonzalez, Jean-Paul, additional, Prugnolle, Franck, additional, and Renaud, François, additional

Published
2014
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43. Multiple independent introductions of Plasmodium falciparum in South America

Author

Yalcindag, Erhan, primary, Elguero, Eric, additional, Arnathau, Céline, additional, Durand, Patrick, additional, Akiana, Jean, additional, Anderson, Timothy J., additional, Aubouy, Agnes, additional, Balloux, François, additional, Besnard, Patrick, additional, Bogreau, Hervé, additional, Carnevale, Pierre, additional, D'Alessandro, Umberto, additional, Fontenille, Didier, additional, Gamboa, Dionicia, additional, Jombart, Thibaut, additional, Le Mire, Jacques, additional, Leroy, Eric, additional, Maestre, Amanda, additional, Mayxay, Mayfong, additional, Ménard, Didier, additional, Musset, Lise, additional, Newton, Paul N., additional, Nkoghé, Dieudonné, additional, Noya, Oscar, additional, Ollomo, Benjamin, additional, Rogier, Christophe, additional, Veron, Vincent, additional, Wide, Albina, additional, Zakeri, Sedigheh, additional, Carme, Bernard, additional, Legrand, Eric, additional, Chevillon, Christine, additional, Ayala, Francisco J., additional, Renaud, François, additional, and Prugnolle, Franck, additional

Published
2011
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44. Risk Factors for Zaireebolavirus–Specific IgG in Rural Gabonese Populations

Author

Nkoghe, Dieudonne, primary, Padilla, Cindy, additional, Becquart, Pierre, additional, Wauquier, Nadia, additional, Moussavou, Ghislain, additional, Akué, Jean Paul, additional, Ollomo, Benjamin, additional, Pourrut, Xavier, additional, Souris, Marc, additional, Kazanji, Mirdad, additional, Gonzalez, Jean-Paul, additional, and Leroy, Eric, additional

Published
2011
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47. Hepatitis C Virus Infection May Lead to Slower Emergence of P. falciparum in Blood

Author

Ouwe-Missi-Oukem-Boyer, Odile, primary, Touré Ndouo, Fousseyni S., additional, Ollomo, Benjamin, additional, Mezui-Me-Ndong, Jérome, additional, Noulin, Florian, additional, Lachard, Isabelle, additional, Ndong-Atome, Guy-Roger, additional, Makuwa, Maria, additional, Roques, Pierre, additional, Branger, Michel, additional, Preux, Pierre-Marie, additional, Mazier, Dominique, additional, and Bisser, Sylvie, additional

Published
2011
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50. Correction: High Prevalence of Both Humoral and Cellular Immunity to Zaire ebolavirus among Rural Populations in Gabon

Author

Becquart, Pierre, primary, Wauquier, Nadia, additional, Mahlakõiv, Tanel, additional, Nkoghe, Dieudonné, additional, Padilla, Cindy, additional, Souris, Marc, additional, Ollomo, Benjamin, additional, Gonzalez, Jean-Paul, additional, De Lamballerie, Xavier, additional, Kazanji, Mirdad, additional, and Leroy, Eric M., additional

Published
2010
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