1. Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results
- Author
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Francolini, Giulio, Ganovelli, Michele, Di Cataldo, Vanessa, Detti, Beatrice, Caini, Saverio, Loi, Mauro, Simontacchi, Gabriele, Desideri, Isacco, Greto, Daniela, Valzano, Marianna, Serni, Sergio, Vaggelli, Luca, Salvestrini, Viola, Visani, Luca, Becherini, Carlotta, Olmetto, Emanuela, Franzese, Ciro, Baldaccini, Davide, Scorsetti, Marta, Sollini, Martina, Chiti, Arturo, Meattini, Icro, Valicenti, Richard K, and Livi, Lorenzo
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Biomedical Imaging ,Aging ,Clinical Research ,Clinical Trials and Supportive Activities ,Cancer ,Urologic Diseases ,Prostate Cancer ,Patient Safety ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Male ,Humans ,Gallium Radioisotopes ,Gallium Isotopes ,Prostatic Neoplasms ,Positron Emission Tomography Computed Tomography ,Prospective Studies ,Neoplasm Recurrence ,Local ,Prostatectomy ,Prostate-Specific Antigen ,Prostate ,Radiotherapy ,Bladder ,Kidney ,Oncology & Carcinogenesis ,Clinical sciences ,Oncology and carcinogenesis - Abstract
PSICHE (NCT05022914) is a prospective trial to test a [68Ga]Ga- PSMA-11 PET/CT imaging tailored strategy. All evaluable patients had biochemical relapse after surgery and underwent centralized [68Ga]Ga-PSMA-11 PET/CT imaging. The treatment was performed according pre-defined criteria. Observation and re-staging at further PSA progression were proposed to patients with negative PSMA and previous postoperative RT. Prostate bed SRT was proposed to all patients with a negative staging or positive imaging within prostate bed. Stereotactic body radiotherapy (SBRT) to all sites of disease was used for all patients with pelvic nodal recurrence (nodal disease
- Published
- 2023