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2 results on '"Olova, Neli"'

1. Interaction of Clq with IgGl, C-reactive protein and pentraxin 3: Mutational studies using recombinant globular head molecules of human Clq A, B, and C chains

Author

Roumenina, Lubka T., Ruseva, Marieta M., Zlatarova, Alexandra, Ghai, Rohit, Kolev, Martin, Olova, Neli, Gadjeva, Mihaela, Agrawal, Alok, Bottazzi, Barbara, Mantovani, Alberto, Reid, Kenneth B.M., Kishore, Uday, and Kojouharova, Mihaela S.

Subjects
Globular proteins -- Structure, Globular proteins -- Chemical properties, C-reactive protein -- Chemical properties, C-reactive protein -- Structure, Biological sciences, Chemistry
Abstract

Clq is the subcomponent of the classical complement pathway that can interact with a range of biochemically and structurally diverse self and nonself ligands. The charged residues belonging to the apex of the global domain of Clq(gClq) heterotrimer as well as the side of the ghB are crucial for Clq binding to these ligands.

Published
2006

2. Existence of different but overlapping IgG- and IgM-binding sites on the globular domain of human C1q

Author

Zlatarova, Alexandra S., Rouseva, Marieta, Roumenina, Lubka T., Gadjeva, Mihaela, Kolev, Martin, Dobrev, Ivan, Olova, Neli, Ghai, Rohit, Jensenius, Jens Chr., Reid, Kenneth B.M., Kishore, Uday, and Kojouharova, Mihaela S.

Subjects
Blood proteins -- Research, Protein binding -- Analysis, Mutagenesis -- Analysis, Cloning -- Usage, Ion exchange chromatography -- Usage, Biological sciences, Chemistry
Abstract

A series of substitution mutants of ghA, ghB, and ghC is generated and its interaction with IgM is examined. The comparative analysis of IgM- and IgC-binding abilities of mutants suggests that the IgG- and IgM-binding sites within the globular domain of Clq are different but may overlap.

Published
2006

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