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387 results on '"Olsaker, I"'

2. Unfolding of population structure in Baltic sheep breeds using microsatellite analysis

Author

Tapio, M., Miceikiene, I., Tapio, I., Kantanen, J, Grislis, Z., Olsaker, I., L-E Holm, Viinalaas, H., Jeppsson, S., and Eythorsdottir, E.

Subjects
Biological diversity -- Research, Genetic variation -- Research, Sheep -- Genetic aspects, Biological sciences
Abstract

Studies of genetic diversity in domestic animals are based on an evaluation of the genetic variation within breeds and genetic relationship among them. Combining this genetic population with phenotypic and aetiological data would enable formulation of the most informed recommendation for gene resource management.

Published
2005

8. Cosmid-derived markers anchoring the bovine genetic map to the physical map

Author

Ferretti, L., Urquhart, B. G. D., Eggen, A., Olsaker, I., Harlizius, B., Castiglioni, B., Mezzelani, A., Toldo, S. Solinas, Thieven, U., Zhang, Y., Morgan, A. L. G., Teres, V. M., Schwerin, M., Martin-Burriel, I., Chowdhary, B. P., Erhardt, G., Nijman, I. J., Cribiu, E. P., Barendse, W., Leveziel, H., Fries, R., and Williams, J. L.

Published
1997
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9. A medium-density genetic linkage map of the bovine genome

Author

Barendse, W., Vaiman, D., Kemp, S. J., Sugimoto, Y., Armitage, S. M., Williams, J. L., Sun, H. S., Eggen, A., Agaba, M., Aleyasin, S. A., Band, M., Bishop, M. D., Buitkamp, J., Byrne, K., Collins, F., Cooper, L., Coppettiers, W., Denys, B., Drinkwater, R. D., Easterday, K., Elduque, C., Ennis, S., Erhardt, G., Ferretti, L., Flavin, N., Gao, Q., Georges, M., Gurung, R., Harlizius, B., Hawkins, G., Hetzel, J., Hirano, T., Hulme, D., Jorgensen, C., Kessler, M., Kirkpatrick, B. W., Konfortov, B., Kostia, S., Kuhn, C., Lenstra, J. A., Leveziel, H., Lewin, H. A., Leyhe, B., Lil, L., Burriel, I. Martin, McGraw, R. A., Miller, J. R., Moody, D. E., Moore, S. S., Nakane, S., Nijman, I. J., Olsaker, I., Pomp, D., Rando, A., Ron, M., Shalom, A., Teale, A. J., Thieven, U., Urquhart, B. G. D., Vage, D. -I., Van de Weghe, A., Varvio, S., Velmala, R., Vilkki, J., Weikard, R., Woodside, C., Womack, J. E., Zanotti, M., and Zaragoza, P.

Published
1997
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11. Differentiation of European cattle by AFLP fingerprinting

Author

Negrini, R., Nijman, I. J., Milanesi, E., Moazami-Goudarzi, K., Williams, J. L., Erhardt, G., Dunner, S., Rodellar, C., Valentini, A., Bradley, D. G., Olsaker, I., Kantanen, J., Ajmone-Marsan, P., and Lenstra, J. A.

Published
2007

17. Consensus and comprehensive linkage maps of bovine chromosome 24

Author

Kurar, E., Barendse, W., Bottema, C. D. K., Davis, S., Föster, M., Kalm, E., Kappes, S. M., Kister, A., Lewin, H. A., Klungland, H., Medjugorac, I., Olsaker, I., Pitchford, W. S., Schmutz, S. M., Taylor, J., Thomsen, H., and Kirkpatrick, B. W.

Published
2002

20. Comprehensive linkage map of bovine chromosome 11

Author

Casas, E., Bennett, G. L., Bottema, C. D. K., Crawford, A., Kalm, E., Kappes, S. M., Kister, A., Lewin, H. A., Lien, S., Morris, C. A., Olsaker, I., Pitchford, W. S., Schmutz, S. M., Thomsen, H., and Xu, N.

Published
2001

21. Comprehensive linkage map of bovine chromosome 27

Author

Casas, E., Sonstegard, T. S., Barendse, W., Bennett, G. L., Bottema, C. D. K., Crawford, A., Grosz, M. D., Kalm, E., Kappes, S. M., Kister, A., Li, Y., Lien, S., Morris, C. A., Olsaker, I., Pitchford, W. S., Schmutz, S. M., Thomsen, H., and Xu, N.

Published
2001

22. Bovine chromosome 4 workshop: consensus and comprehensive linkage maps

Author

Casas, E, Barendse, W, Beever, J E, Burns, B M, Davis, S K, Erhardt, G, Förster, M, Gomez-Raya, L, Kalm, E, Kappes, S M, Klungland, H, Lewin, H A, Lien, S, Olsaker, I, Reinsch, N, Schwerin, M, Song, Y, Taylor, J F, Thomsen, H, Våge, D I, Wu, X, Xu, N, and Yeh, C-C

Published
1999

44. Cosmid-derived markers anchoring the bovine genetic map to the physical map

Author

Ferretti, L., Urquhart, B., Eggen, A., Olsaker, I., Harlizius, B., Castiglioni, B., Mezzelani, A., Toldo, S., Thieven, U., Zhang, Y., Morgan, A., Teres, V., Schwerin, M., Martin-Burriel, I., Chowdhary, B., Erhardt, G., Nijman, I., Cribiu, E., Barendse, W., Leveziel, H., Fries, R., Williams, J., Ferretti, L., Urquhart, B., Eggen, A., Olsaker, I., Harlizius, B., Castiglioni, B., Mezzelani, A., Toldo, S., Thieven, U., Zhang, Y., Morgan, A., Teres, V., Schwerin, M., Martin-Burriel, I., Chowdhary, B., Erhardt, G., Nijman, I., Cribiu, E., Barendse, W., Leveziel, H., Fries, R., and Williams, J.

Abstract

The mapping strategy for the bovine genome described in this paper uses large insert clones as a tool for physical mapping and as a source of highly polymorphic microsatellites for genetic typing, and was one objective of the BovMap Project funded by the European Union (UE). Eight-three cosmid and phage clones were characterized and used to physically anchor the linkage groups defining all the bovine autosomes and the X Chromosome (Chr). By combining physical and genetic mapping, clones described in this paper have led to the identification of the linkage groups corresponding to Chr 9, 12, 16, and 25. In addition, anchored loci from this study were used to orient the linkage groups corresponding to Chr 3, 7, 8, 9, 13, 16, 18, 19, and 28 as identified in previously published maps. Comparison of the estimated size of the physical and linkage maps suggests that the genetic length of the bovine genome may be around 4000 cM

Published
2018

45. Identification of candidate genes affecting chronic subclinical mastitis in Norwegian Red cattle: combining genome‐wide association study, topologically associated domains and pathway enrichment analysis.

Author

Kirsanova, E., Heringstad, B., Lewandowska‐Sabat, A., and Olsaker, I.

Subjects
BOVINE mastitis, MASTITIS, FOS oncogenes, SOMATIC cells, AP-1 transcription factor, CATTLE
Abstract

Summary: The aim of this study was to identify genes associated with chronic subclinical mastitis (SCM) in Norwegian Red (NR) cattle. Twelve SCM traits defined based on fixed threshold for test‐day somatic cell count (SCC) were, together with lactation‐average somatic cell score (LSCS) used for association and pathway enrichment analyses. A GWAS was performed on 3795 genotyped NR bulls with 777K SNP data and phenotypic information from 7 300 847 test‐day SCC observations from 3 543 764 cows. At 5% chromosome‐wide significance level 36 unique SNP were detected to be associated with one or more of the traits. These SNPs were analysed for linked genes using genomic positions of topologically associated domains (TAD). For the SCM traits with SCC >50 000 and >100 000 cells/ml on two test‐days in a row and LSCS, the same top significant genes were identified – checkpoint clamp loader component (RAD17) and cyclin B1 (CCNB1). The SCM traits with SCC >250 000, 300 000, 350 000 or 400 000 cells/ml on two test‐days in a row and D400 (number of days before the first case with SCC >400 000 cells/ml) displayed similar top significant genes: acyl‐CoA thioesterase 2 and 4 (ACOT2; ACOT4). For the traits SCM200_3 (SCC >200 000 cells/ml on three test‐days in a row) and SCM150, SCM200 (SCC >150 000; 200 000 cells/ml on two test‐days in a row) a group of chemokine (C–X–C motif) ligand genes and the Fos proto‐oncogene, AP‐1 transcription factor subunit (FOS) gene, were identified. Further functional studies of these identified candidate genes are necessary to clarify their actual role in development of chronic SCM in NR cattle. [ABSTRACT FROM AUTHOR]

Published
2020
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46. Reduced genetic structure of north Ethiopian cattle revealed by Y-chromosome analysis

Author

Li, M.H., Zerabruk, M., Vangen, O., Olsaker, I., and Kantanen, J.

Subjects
Y chromosome -- Analysis, Y chromosome -- Structure, Gene flow -- Analysis, Cattle -- Genetic aspects, Biological sciences
Abstract

Five Y-chromosome microsatellite markers from seven north Ethiopian cattle populations is analysed to assess the paternal gene pool and to explore the mechanisms behind the genetic structure. It is found that there is common but limited strong male-mediated gene flow among paternal origin of the north Ethiopian cattle populations.

Published
2007

47. Marker-assisted conservation of European cattle breeds: an evaluation

Author

Lenstra, J.A., Nijman, I.J., Eding, H., Engelsma, K.A., Bijma, P., Garcia, D., Canon, J., Dunner, S., Moazami Goudarzi, K., Laloe, D., Williams, J.L., Wiener, P., Burton, D., Erhardt, G., Jann, O., Weimann, C., Prinzenberg, E.M., Harlizius, B., Barre Dirie, A., Mengers, A., Looft, C., Kalm, E., Rodellar, C., Zaragoza, P., Martin Burriel, I., Sanchez, A., Ajmone Marsan, P., Negrini, R., Milanesi, E., Valentini, A., Savarese, M.C., Marchitelli, C., Zanotti, M., Ceriotti, G., Pilla, F., Bruzzone, A., Iamartino, D., Olsaker, I., Holm, L.E., Mommens, G., Dolf, G., Hiemstra, S.H., and Windig, J.J.

Subjects
Genetic Markers, Conservation of Natural Resources, Genotype, business.industry, Cattle, Conservation, Genetic diversity, Kinship, Microsatellite, Weitzman, Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico, Genetic Variation, General Medicine, Breeding, Biology, Biotechnology, Environmental protection, Genetics, Animals, Animal Science and Zoology, business, Microsatellite Repeats
Abstract

Two methods have been developed for the assessment of conservation priorities on the basis of molecular markers. According to the Weitzman approach, contributions to genetic diversity are derived from genetic distances between populations. Alternatively, diversity within and across populations is optimized by minimizing marker-estimated kinships. We have applied, for the first time, both methods to a comprehensive data set of 69 European cattle breeds, including all cosmopolitan breeds and several local breeds, for which genotypes of 30 microsatellite markers in 25-50 animals per breed have been obtained. Both methods were used to calculate the gain in diversity if a breed was added to a set of nine non-endangered breeds. Weitzman-derived diversities were confounded by genetic drift in isolated populations, which dominates the genetic distances but does not necessarily increase the conservation value of a breed. Marker-estimated kinships across populations were less disturbed by genetic drift than the Weitzman diversities and assigned high conservation values to Mediterranean breeds, which indeed have genetic histories that differ from the non-endangered breeds. Prospects and limitations of marker-assisted decisions on conservation priorities are discussed.

Published
2006
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48. Revisiting AFLP fingerprinting for an unbiased assessment of genetic structure and differentiation of taurine and zebu cattle

Author

Utsunomiya, Yuri T., Bomba, Lorenzo, Lucente, Giordana, Colli, Licia, Negrini, Riccardo, Lenstra, Johannes A., Erhardt, Georg, Garcia, José F., Ajmone-Marsan, Paolo, Moazami-Goudarzi, K., Williams, J., Wiener, P., Olsaker, I., Kantanen, J., Dunner, S., Cañón, J., Rodellar, C., Martín-Burriel, I., Valentini, A., Zanotti, M., Holm, L. E., Eythorsdottir, E., Mommens, G., Polygen, Van Haeringen, Nijman, I. J., Dolf, G., Bradley, D. G., Algemeen Onderzoek DGK, LS IRAS Tox Algemeen, Dep Natuurkunde, Faculty of Veterinary Medicine Research Groups, Algemeen Onderzoek DGK, LS IRAS Tox Algemeen, Dep Natuurkunde, Faculty of Veterinary Medicine Research Groups, Universidade Estadual Paulista (Unesp), Univ Cattol Sacro Cuore, Univ Utrecht, and Univ Giessen

Subjects
Genetic Markers, Conservation of Natural Resources, AFLP, Genotype, ved/biology.organism_classification_rank.species, Introgression, Breeding, Genetic differentiation, Revisiting AFLP, Ascertainment bias, Genetic variation, genetic structure, Genetics, Animals, Cluster Analysis, Genetics(clinical), Amplified Fragment Length Polymorphism Analysis, Genetics (clinical), Models, Genetic, Settore AGR/17 - ZOOTECNICA GENERALE E MIGLIORAMENTO GENETICO, biology, ved/biology, Taurine cattle, Genetic Variation, Aurochs, Zebu, biology.organism_classification, humanities, Genetics, Population, Genetic marker, Genetic structure, Amplified fragment length polymorphism, Cattle, Research Article
Abstract

Made available in DSpace on 2014-12-03T13:07:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-04-17Bitstream added on 2014-12-03T13:24:33Z : No. of bitstreams: 1 WOS000335177200001.pdf: 750548 bytes, checksum: 075b52b143f984a79a48dec1b9a68ce6 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: Descendants from the extinct aurochs (Bos primigenius), taurine (Bos taurus) and zebu cattle (Bos indicus) were domesticated 10,000 years ago in Southwestern and Southern Asia, respectively, and colonized the world undergoing complex events of admixture and selection. Molecular data, in particular genome-wide single nucleotide polymorphism (SNP) markers, can complement historic and archaeological records to elucidate these past events. However, SNP ascertainment in cattle has been optimized for taurine breeds, imposing limitations to the study of diversity in zebu cattle. As amplified fragment length polymorphism (AFLP) markers are discovered and genotyped as the samples are assayed, this type of marker is free of ascertainment bias. In order to obtain unbiased assessments of genetic differentiation and structure in taurine and zebu cattle, we analyzed a dataset of 135 AFLP markers in 1,593 samples from 13 zebu and 58 taurine breeds, representing nine continental areas.Results: We found a geographical pattern of expected heterozygosity in European taurine breeds decreasing with the distance from the domestication centre, arguing against a large-scale introgression from European or African aurochs. Zebu cattle were found to be at least as diverse as taurine cattle. Western African zebu cattle were found to have diverged more from Indian zebu than South American zebu. Model-based clustering and ancestry informative markers analyses suggested that this is due to taurine introgression. Although a large part of South American zebu cattle also descend from taurine cows, we did not detect significant levels of taurine ancestry in these breeds, probably because of systematic backcrossing with zebu bulls. Furthermore, limited zebu introgression was found in Podolian taurine breeds in Italy.Conclusions: The assessment of cattle diversity reported here contributes an unbiased global view to genetic differentiation and structure of taurine and zebu cattle populations, which is essential for an effective conservation of the bovine genetic resources. Univ Estadual Paulista, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, Brazil Univ Cattol Sacro Cuore, Inst Zootech, Piacenza, Italy Univ Cattol Sacro Cuore, BioDNA Biodivers & Ancient DNA Res Ctr, Piacenza, Italy Univ Utrecht, Fac Vet Med, Utrecht, Netherlands Univ Giessen, Inst Anim Breeding & Genet, D-35390 Giessen, Germany Univ Estadual Paulista, Fac Med Vet Aracatuba, BR-16050680 Aracatuba, SP, Brazil Univ Estadual Paulista, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, Brazil Univ Estadual Paulista, Fac Med Vet Aracatuba, BR-16050680 Aracatuba, SP, Brazil FAPESP: 11/16643-2 FAPESP: 13/12829-0

Published
2014
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50. Strengthening insights into host responses to mastitis infection in ruminants by combining heterogeneous microarray data sources

Author

Genini S., Badaoui B., Sclep G., Bishop S.C., Waddington D., Pinard van der Laan M.H., Klopp C., Cabau C., Seyfert H.M., Petzl W., Jensen K., Glass E.J., de Greeff A., Smith H.E., Smits M.A., Olsaker I., Boman G.M., Pisoni G., Moroni P., Castiglioni B., and C

Subjects
mastitis infection, Meta-analysis, microarray analysis, immune response
Abstract

Gene expression profiling studies of mastitis in ruminants have provided key but fragmented knowledge for the understanding of the disease. A systematic combination of different expression profiling studies via meta-analysis techniques has the potential to test the extensibility of conclusions based on single studies. Using the program Pointillist, we performed meta-analysis of transcription-profiling data from six independent studies of infections with mammary gland pathogens, including samples from cattle challenged in vivo with S. aureus, E. coli, and S. uberis, samples from goats challenged in vivo with S. aureus, as well as cattle macrophages and ovine dendritic cells infected in vitro with S. aureus. We combined different time points from those studies, testing different responses to mastitis infection: overall (common signature), early stage, late stage, and cattle-specific. This meta-analysis approach reinforces previous findings but also reveals several novel themes, including the involvement of genes, biological functions, and pathways that were not identified in individual studies. As such, it provides an interesting proof of principle for future studies combining information from diverse heterogeneous sources.

Published
2011

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