1. PROTECTIVE EFFECTS OF PROPOLIS ON GAMMA- IRRADIATED NIGELLA SATIVA EXTRACT INDUCED BLOOD AND IMMUNE CHANGES IN WISTAR RATS
- Author
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Omniya Mahmoud Abdel-Hamid, O. M. Saleh, Ahmed M. Mansour, and Mohamed Mohamed Soliman
- Subjects
Kidney ,business.industry ,Nigella sativa ,Propolis ,Pharmacology ,Biochemistry ,Renal corpuscle ,Desquamation ,chemistry.chemical_compound ,Immune system ,medicine.anatomical_structure ,chemistry ,Immunology ,medicine ,Urea ,Secretion ,sense organs ,medicine.symptom ,skin and connective tissue diseases ,business ,Biotechnology - Abstract
The present study conducted to test the effect of Nigella Sativa (NS, 5 mg kg -1 of body weight), or γirradiated Nigella Sativa (GRNS) on the changes of blood component profiles, liver, kidney functions and immune cytokines secretion in male Wistar rats. Moreover, the possible protection by propolis (200 mg kg -1 B. W.) on the changes induced by NS and GRNS was examined. Results revealed that both NS and GRNS administration for two weeks induced changes in blo od, GPT, GOT and urea levels and co-administration with propolis significantly ameliorated such change s. Also, liver histology showed numerous vacuolar degeneration and fatty changes in γ-irradiated groups which disappeared in presence of propolis. Kidney histology of NS administered rats showed less lymphocytic infiltration, while GRNS groups showed desquamation in the cytoplasm of the renal tubules, hemorrhage in the renal corpuscle and lymphocytic infiltration which disappeared when propolis given together with GRNS. Finally propolis induced protec tive effect on the changes induced in TNF-α and IL-10 secretion by either NS or GRNS in Wistar rats. In conclusion, the findings of present study clarified the protective effect of propolis on changes induc ed by γirradiated NS on blood, liver, kidney and cytokines changes in Wistar rats.
- Published
- 2013