38 results on '"Ontoria, Jesus M."'
Search Results
2. Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors
3. Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors
4. Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates
5. Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT
6. Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors
7. Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction
8. New synthesis of alpha-amino acid N-carboxy anhydrides through Baeyer-Villiger oxidation of alpha-keto beta-lactams
9. Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro
10. Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides
11. Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides.
12. Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs
13. N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists
14. Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors
15. Synthesis and biological evaluation of substituted 2-phenyl-2 H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors
16. Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
17. Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors
18. Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model
19. Improved modular synthesis of thieno[3,2- b]pyrroles and thieno[2,3- b]pyrroles
20. Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors
21. 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors
22. Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors
23. Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors
24. Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy
25. Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors
26. ChemInform Abstract: Improved Modular Synthesis of Thieno[3,2‐b]pyrroles and Thieno[2,3‐b]pyrroles.
27. Identification of Thieno[3,2‐b]pyrroles as Allosteric Inhibitors of Hepatitis C Virus NS5B Polymerase.
28. The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease
29. SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease
30. Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease
31. Identification of thieno[3,2- b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase
32. Synthesis of Two Novel Cyclic Biphenyl Ether Analogs of an Inhibitor of HCV NS3 Protease
33. A concise stereoselective approach to β-Alkylaspartates from β-Lactams via [2 + 2] cycloaddition reaction of ketenes to glyoxylic ester-derived imines.
34. Oxidation of alcohols using bis(trichloromethyl) carbonate as activator of dimethyl sulfoxide
35. Preparation of 3-alkyl .beta.-lactams via the ketene imine cycloaddition reaction using .alpha.-(phenylthio)alkanoyl halides as starting materials: application to the synthesis of (.+-.)-carbapenem building blocks and related compounds
36. The Reformatskii type reaction of Gilman and Speeter in the preparation of valuable .beta.-lactams in carbapenem synthesis: scope and synthetic utility
37. Preparation of chiral 3-unsubstituted β-lactams from 3-hydroxy β-lactams by using the alkoxyketene-imine cycloaddition reaction as an approach to the azetidinone ring: A formal synthesis of the carbapenem antibiotic (+)-PS-5.
38. Alkyl(phenylthio)ketenes as synthetic equivalents of monoalkylketenes: A concise general route to 3-alkyl β-lactams as carbapenem building-blocks
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.