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2. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

Author

Lechner, Matt, Schartinger, Volker H., Steele, Christopher D., Nei, Wen Long, Ooft, Marc Lucas, Schreiber, Liesa-Marie, Pipinikas, Christodoulos P., Chung, Grace Tin-Yun, Chan, Yuk Yu, Wu, Feng, To, Ka-Fai, Tsang, Chi Man, Pearce, Wayne, Morelli, Daniele, Philpott, Martin, Masterson, Liam, Nibhani, Reshma, Wells, Graham, Bell, Christopher G., Koller, Julia, Delecluse, Susanne, Yip, Yim Ling, Liu, Jacklyn, Forde, Cillian T., Forster, Martin D., Jay, Amrita, Dudás, József, Krapp, Annika, Wan, Simon, Uprimny, Christian, Sprung, Susanne, Haybaeck, Johannes, Fenton, Tim R., Chester, Kerry, Thirlwell, Christina, Royle, Gary, Marafioti, Teresa, Gupta, Rajeev, Indrasari, Sagung Rai, Herdini, Camelia, Slim, Mohd Afiq Mohd, Indrawati, I., Sutton, Liam, Fles, Renske, Tan, Bing, Yeong, Joe, Jain, Amit, Han, Shuting, Wang, Haitao, Loke, Kelvin S. H., He, Wan, Xu, Ruilian, Jin, Hongtao, Cheng, Zhiqiang, Howard, David, Hwang, Peter H., Le, Quynh-Thu, Tay, Joshua K., West, Robert B., Tsao, Sai Wah, Meyer, Tim, Riechelmann, Herbert, Oppermann, Udo, Delecluse, Henri-Jacques, Willems, Stefan M., Chua, Melvin L. K., Busson, Pierre, Lo, Kwok Wai, Wollmann, Guido, Pillay, Nischalan, Vanhaesebroeck, Bart, and Lund, Valerie J.

Published
2021
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4. Genetic and epigenetic prognosticators of neuroendocrine tumours of the GI tract, liver, biliary tract and pancreas: A systematic review and meta‐analysis.

Author

Mestre‐Alagarda, Claudia, Srirajaskanthan, Rajaventhan, Zen, Yoh, Giwa, Mojisola, Howard, Mark, and Ooft, Marc Lucas

Subjects
GASTROINTESTINAL system, BILIARY tract, NEUROENDOCRINE tumors, PANCREAS, SINGLE nucleotide polymorphisms, GALLBLADDER, INTRAHEPATIC bile ducts
Abstract

Multiple recurrent genetic and epigenetic aberrations have been associated with worse prognosis in multiple studies of neuroendocrine tumours (NETs), but these have been mainly small cohorts and univariate analysis. This review and meta‐analysis will focus upon the literature available on NETs of the gastrointestinal (GI) tract, liver, biliary tract and pancreas. PubMed and Embase were searched for publications that investigated the prognostic value of (epi)genetic changes of neuroendocrine tumours. A meta‐analysis was performed assessing the association of the (epi)genetic alterations with overall survival (OS), disease‐free survival (DFS) or locoregional control (LRC). In the pancreas DAXX/ATRX [hazard ratio (HR) = 3.29; 95% confidence interval (CI) = 2.28–4.74] and alternative lengthening telomeres (ALT) activation (HR = 8.20; 95% CI = 1.40–48.07) showed a pooled worse survival. In the small bowel NETs gains on chromosome 14 were associated with worse survival (HR 2.85; 95% CI = 1.40–5.81). NETs from different anatomical locations must be regarded as different biological entities with diverging molecular prognosticators, and epigenetic changes being important to the pathogenesis of these tumours. This review underpins the prognostic drivers of pancreatic NET which lie in mutations of DAXX/ATRX and ALT pathways. However, there is reaffirmation that prognostic molecular biomarkers of small bowel NETs should be sought in copy number variations (CNVs) rather than in single nucleotide variations (SNVs). This review also reveals how little is known about the prognostic significance of epigenetics in NETs. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Erratum to: Differences in cancer gene copy number alterations between Epstein-Barr virus-positive and Epstein-Barr virus-negative nasopharyngeal carcinoma (Head & Neck, (2018), 40, 9, (1986-1998), 10.1002/hed.25195)

Author

Ooft, Marc Lucas, van Ipenburg, Jolique, van de Loo, Rob J M, de Jong, Rick, Moelans, Cathy B., de Bree, Remco, de Herdt, Martine J, Koljenovic, Senada, Baatenburg de Jong, Robert J., Hardillo, José A, Willems, Stefan M., Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Abstract

Differences in cancer gene copy number alterations between Epstein-Barr virus-positive and Epstein-Barr virus-negative nasopharyngeal carcinoma Marc Lucas Ooft MD, PhD1 | Jolique van Ipenburg MD2 | Rob J. M. van de Loo1 | Rick de Jong1 | Cathy B. Moelans PhD1 | Remco de Bree MD, PhD3 | Martine J. de Herdt Ir4 | Senada Koljenović MD, PhD2 | R. Baatenburg de Jong MD, PhD5 | J. Hardillo MD, PhD5 | Stefan Martin Willems MD, PhD1 1Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands 2Department of Pathology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands 3Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands 4Department of Otorhinolaryngology - Head and Neck Surgery, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands 5Department of Otorhinolaryngology - Head and Neck Surgery, Erasmus Medical Center Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands Correspondence Stefan Willems, Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands Email: s.m.willems-4@umcutrecht.nl Head & Neck. 2018;40:1986-1998 DOI: 10.1002/hed.25195 In the above-mentioned article, author name “R. Baatenburg de Jong” should be updated to “Robert J. Baatenburg de Jong.” We apologize for the error.

Published
2019

8. Differences in cancer gene copy number alterations between Epstein-Barr virus-positive and Epstein-Barr virus-negative nasopharyngeal carcinoma

Author

Ooft, Marc Lucas, van Ipenburg, Jolique, van de Loo, Rob J.M., de Jong, Rick, Moelans, Cathy B., de Bree, Remco, de Herdt, Martine J., Koljenović, Senada, de Jong, R. Baatenburg, Hardillo, J., Willems, Stefan Martin, Ooft, Marc Lucas, van Ipenburg, Jolique, van de Loo, Rob J.M., de Jong, Rick, Moelans, Cathy B., de Bree, Remco, de Herdt, Martine J., Koljenović, Senada, de Jong, R. Baatenburg, Hardillo, J., and Willems, Stefan Martin

Published
2018

9. Differences in cancer gene copy number alterations between Epstein-Barr virus-positive and Epstein-Barr virus-negative nasopharyngeal carcinoma

Author

Pathologie Groep Blokx, Pathologie Opleiding, Cancer, Pathologie Groep Van Diest, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Ooft, Marc Lucas, van Ipenburg, Jolique, van de Loo, Rob J.M., de Jong, Rick, Moelans, Cathy B., de Bree, Remco, de Herdt, Martine J., Koljenović, Senada, de Jong, R. Baatenburg, Hardillo, J., Willems, Stefan Martin, Pathologie Groep Blokx, Pathologie Opleiding, Cancer, Pathologie Groep Van Diest, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, Ooft, Marc Lucas, van Ipenburg, Jolique, van de Loo, Rob J.M., de Jong, Rick, Moelans, Cathy B., de Bree, Remco, de Herdt, Martine J., Koljenović, Senada, de Jong, R. Baatenburg, Hardillo, J., and Willems, Stefan Martin

Published
2018

10. Differences in cancer gene copy number alterations between Epstein-Barr virus-positive and Epstein-Barr virus-negative nasopharyngeal carcinoma

Author

Ooft, Marc Lucas, primary, van Ipenburg, Jolique, additional, van de Loo, Rob J. M., additional, de Jong, Rick, additional, Moelans, Cathy B., additional, de Bree, Remco, additional, de Herdt, Martine J., additional, Koljenović, Senada, additional, de Jong, R. Baatenburg, additional, Hardillo, J., additional, and Willems, Stefan Martin, additional

Published
2018
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