4 results on '"Oole, E. (Edwin)"'
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2. DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition i
- Author
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Mohd-Sarip, A. (Adone), Teeuwssen, M. (Miriam), Bot, A.G. (Alice), Herdt, M.J. (Maria) de, Willems, S.M. (Stefan Martin), Baatenburg de Jong, R.J. (Robert Jan), Looijenga, L.H.J. (Leendert), Zatreanu, D. (Diana), Bezstarosti, K. (Karel), Riet, J. (Job) van, Oole, E. (Edwin), IJcken, W.F.J. (Wilfred) van, Werken, H.J.G. (Harmen) van de, Demmers, J.A.A. (Jeroen), Fodde, R. (Riccardo), Verrijzer, C.P. (Peter), Mohd-Sarip, A. (Adone), Teeuwssen, M. (Miriam), Bot, A.G. (Alice), Herdt, M.J. (Maria) de, Willems, S.M. (Stefan Martin), Baatenburg de Jong, R.J. (Robert Jan), Looijenga, L.H.J. (Leendert), Zatreanu, D. (Diana), Bezstarosti, K. (Karel), Riet, J. (Job) van, Oole, E. (Edwin), IJcken, W.F.J. (Wilfred) van, Werken, H.J.G. (Harmen) van de, Demmers, J.A.A. (Jeroen), Fodde, R. (Riccardo), and Verrijzer, C.P. (Peter)
- Abstract
The Nucleosome Remodeling and Deacetylase (NURD) complex is a key regulator of cell differentiation that has also been implicated in tumorigenesis. Loss of the NURD subunit Deleted in Oral Cancer 1 (DOC1) is associated with human oral squamous cell carcinomas (OSCCs). Here, we show that restoration of DOC1 expression in OSCC cells leads to a reversal of epithelial-mesenchymal transition (EMT). This is caused by the DOC1-dependent targeting of NURD to repress key transcriptional regulators of EMT. NURD recruitment drives extensive epigenetic reprogramming, including eviction of the SWI/SNF remodeler, formation of inaccessible chromatin, H3K27 deacetylation, and binding of PRC2 and KDM1A, followed by H3K27 methylation and H3K4 demethylation. Strikingly, depletion of SWI/SNF mimics the effects of DOC1 re-expression. Our results suggest that SWI/SNF and NURD function antagonistically to control chromatin state and transcription. We propose that disturbance of this dynamic equilibrium may lead to defects in gene expression that promote oncogenesis.
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- 2017
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3. Genetic variants in RBFOX3 are associated with sleep latency
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Amin, N. (Najaf), Allebrandt, K.V., Spek, A. (Ashley) van der, Müller-Myhsok, B. (B.), Hek, K. (Karin), Teder-Laving, M. (Maris), Hayward, C. (Caroline), Esko, T. (Tõnu), Mill, J. van, Mbarek, H., Watson, N.F. (Nathaniel F), Melville, S.A. (Scott), Del Greco, F.M. (Fabiola), Byrne, E.M. (Enda), Oole, E. (Edwin), Kolcic, I. (Ivana), Chen, T.H., Evans, D.S. (Daniel), Coresh, J. (Josef), Vogelzangs, N. (Nicole), Karjalainen, J. (Juha), Willemsen, G.A.H.M. (Gonneke), Gharib, S.A. (Sina), Zgaga, L. (Lina), Mihailov, E. (Evelin), Stone, K.L. (Katie L), Campbell, H. (Harry), Brouwer, R.W.W. (Rutger), Demirkan, A. (Ayşe), Isaacs, A.J. (Aaron), Dogas, Z., Marciante, K. (Kristin), Campbell, S. (Susan), Borovecki, F. (Fran), Luik, A.I. (Annemarie), Li, M. (Man), Hottenga, J.J. (Jouke Jan), Huffman, J.E. (Jennifer), van den hout, M.C.G.N. (Mirjam), Cummings, S.R. (Steven R.), Aulchenko, Y.S. (Yurii), Gehrman, P.R. (Philip), Uitterlinden, A.G. (André), Wichmann, H.E. (Heinz Erich), Müller-Nurasyid, M. (Martina), Fehrmann, R.S.N. (Rudolf), Montgomery, G.W. (Grant), Hofman, A. (Albert), Kao, W.H.L. (Wen Hong Linda), Oostra, B.A. (Ben), Wright, A. (Alan), Vink, J.M. (Jacqueline), Wilson, J.F. (James F), Pramstaller, P.P. (Peter Paul), Hicks, A.A. (Andrew), Polasek, O. (Ozren), Punjabi, N.M. (Naresh), Redline, S. (Susan), Psaty, B.M. (Bruce), Heath, A.C. (Andrew C.), Merrow, M., Tranah, G.J. (Gregory), Gottlieb, D.J. (Daniel J), Boomsma, D.I. (Dorret), Martin, N.G. (Nicholas), Rudan, I. (Igor), Tiemeier, H.W. (Henning), IJcken, W.F.J. (Wilfred) van, Penninx, B.W.J.H., Metspalu, A. (Andres), Meitinger, T. (Thomas), Franke, L. (Lude), Roenneberg, T., Duijn, C.M. (Cornelia) van, Amin, N. (Najaf), Allebrandt, K.V., Spek, A. (Ashley) van der, Müller-Myhsok, B. (B.), Hek, K. (Karin), Teder-Laving, M. (Maris), Hayward, C. (Caroline), Esko, T. (Tõnu), Mill, J. van, Mbarek, H., Watson, N.F. (Nathaniel F), Melville, S.A. (Scott), Del Greco, F.M. (Fabiola), Byrne, E.M. (Enda), Oole, E. (Edwin), Kolcic, I. (Ivana), Chen, T.H., Evans, D.S. (Daniel), Coresh, J. (Josef), Vogelzangs, N. (Nicole), Karjalainen, J. (Juha), Willemsen, G.A.H.M. (Gonneke), Gharib, S.A. (Sina), Zgaga, L. (Lina), Mihailov, E. (Evelin), Stone, K.L. (Katie L), Campbell, H. (Harry), Brouwer, R.W.W. (Rutger), Demirkan, A. (Ayşe), Isaacs, A.J. (Aaron), Dogas, Z., Marciante, K. (Kristin), Campbell, S. (Susan), Borovecki, F. (Fran), Luik, A.I. (Annemarie), Li, M. (Man), Hottenga, J.J. (Jouke Jan), Huffman, J.E. (Jennifer), van den hout, M.C.G.N. (Mirjam), Cummings, S.R. (Steven R.), Aulchenko, Y.S. (Yurii), Gehrman, P.R. (Philip), Uitterlinden, A.G. (André), Wichmann, H.E. (Heinz Erich), Müller-Nurasyid, M. (Martina), Fehrmann, R.S.N. (Rudolf), Montgomery, G.W. (Grant), Hofman, A. (Albert), Kao, W.H.L. (Wen Hong Linda), Oostra, B.A. (Ben), Wright, A. (Alan), Vink, J.M. (Jacqueline), Wilson, J.F. (James F), Pramstaller, P.P. (Peter Paul), Hicks, A.A. (Andrew), Polasek, O. (Ozren), Punjabi, N.M. (Naresh), Redline, S. (Susan), Psaty, B.M. (Bruce), Heath, A.C. (Andrew C.), Merrow, M., Tranah, G.J. (Gregory), Gottlieb, D.J. (Daniel J), Boomsma, D.I. (Dorret), Martin, N.G. (Nicholas), Rudan, I. (Igor), Tiemeier, H.W. (Henning), IJcken, W.F.J. (Wilfred) van, Penninx, B.W.J.H., Metspalu, A. (Andres), Meitinger, T. (Thomas), Franke, L. (Lude), Roenneberg, T., and Duijn, C.M. (Cornelia) van
- Abstract
Time to fall asleep (sleep latency) is a major determinant of sleep quality. Chronic, long sleep latency is a major characteristic of sleep-onset insomnia and/or delayed sleep phase syndrome. In this study we aimed to discover common polymorphisms that contribute to the genetics of sleep latency. We performed a meta-analysis of genome-wide association studies (GWAS) including 2 572 737 single nucleotide polymorphisms (SNPs) established in seven European cohorts including 4242 individuals. We found a cluster of three highly correlated variants (rs9900428, rs9907432 and rs7211029) in the RNA-binding protein fox-1 homolog 3 gene (RBFOX3) associated with sleep latency (P-values=5.77 × 10-08, 6.59 × 10- 08 and 9.17 × 10- 08). These SNPs were replicated in up to 12 independent populations including 30 377 individuals (P-values=1.5 × 10- 02, 7.0 × 10- 03 and 2.5 × 10- 03; combined meta-analysis P-values=5.5 × 10-07, 5.4 × 10-07 and 1.0 × 10-07). A functional prediction of RBFOX3 based
- Published
- 2016
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4. PLD3 variants in population studies
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Lee, S.J. (Sven) van der, Holstege, H. (Henne), Wong, T.H. (Tsz Hang), Jakobsdottir, M. (Margret), Bis, J.C. (Joshua), Chouraki, V. (Vincent), Rooij, J.G.J. (Jeroen) van, Grove, M.L. (Megan), Smith, A.V. (Davey), Amin, N. (Najaf), Choi, S.-H. (Seung-Hoan), Beiser, A. (Alexa), Garcia, M. (Melissa), IJcken, W.F.J. (Wilfred) van, Pijnenburg, Y.A.L. (Yolande), Louwersheimer, E. (Eva), Brouwer, R.W.W. (Rutger), van den hout, M.C.G.N. (Mirjam), Oole, E. (Edwin), Eirkisdottir, G. (Gudny), Levy, D. (Daniel), Rotter, J.I. (Jerome I.), Emilsson, V. (Valur), O'Donnell, C.J. (Christopher), Aspelund, T. (Thor), Uitterlinden, A.G. (André), Launer, L.J. (Lenore), Hofman, A. (Albert), Boerwinkle, E.A. (Eric), Psaty, B.M. (Bruce), DeStefano, A.L. (Anita), Scheltens, P. (Philip), Seshadri, S. (Sudha), Swieten, J.C. (John) van, Gudnason, V. (Vilmundur), Flier, W.M. (Wiesje) van der, Ikram, M.A. (Arfan), Duijn, C.M. (Cornelia) van, Lee, S.J. (Sven) van der, Holstege, H. (Henne), Wong, T.H. (Tsz Hang), Jakobsdottir, M. (Margret), Bis, J.C. (Joshua), Chouraki, V. (Vincent), Rooij, J.G.J. (Jeroen) van, Grove, M.L. (Megan), Smith, A.V. (Davey), Amin, N. (Najaf), Choi, S.-H. (Seung-Hoan), Beiser, A. (Alexa), Garcia, M. (Melissa), IJcken, W.F.J. (Wilfred) van, Pijnenburg, Y.A.L. (Yolande), Louwersheimer, E. (Eva), Brouwer, R.W.W. (Rutger), van den hout, M.C.G.N. (Mirjam), Oole, E. (Edwin), Eirkisdottir, G. (Gudny), Levy, D. (Daniel), Rotter, J.I. (Jerome I.), Emilsson, V. (Valur), O'Donnell, C.J. (Christopher), Aspelund, T. (Thor), Uitterlinden, A.G. (André), Launer, L.J. (Lenore), Hofman, A. (Albert), Boerwinkle, E.A. (Eric), Psaty, B.M. (Bruce), DeStefano, A.L. (Anita), Scheltens, P. (Philip), Seshadri, S. (Sudha), Swieten, J.C. (John) van, Gudnason, V. (Vilmundur), Flier, W.M. (Wiesje) van der, Ikram, M.A. (Arfan), and Duijn, C.M. (Cornelia) van
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- 2015
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