1. Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
- Author
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Fumagalli, A. (Arianna), Oost, K.C. (Koen C.), Kester, L. (Lennart), Morgner, J. (Jessica), Bornes, L. (Laura), Bruens, L. (Lotte), Spaargaren, L. (Lisa), Azkanaz, M. (Maria), Schelfhorst, T. (Tim), Beerling, E. (Evelyne), Heinz, M.C. (Maria C.), Postrach, D. (Daniel), Seinstra, D. (Danielle), Sieuwerts, A.M. (Anieta), Martens, J.W.M. (John), van der Elst, S. (Stefan), van Baalen, M. (Martijn), Bhowmick, D. (Debajit), Vrisekoop, N. (Nienke), Ellenbroek, S.I.J. (Saskia I J), Suijkerbuijk, S.J.E. (Saskia J E), Snippert, H.J. (Hugo J.), van Rheenen, J. (Jacco), Fumagalli, A. (Arianna), Oost, K.C. (Koen C.), Kester, L. (Lennart), Morgner, J. (Jessica), Bornes, L. (Laura), Bruens, L. (Lotte), Spaargaren, L. (Lisa), Azkanaz, M. (Maria), Schelfhorst, T. (Tim), Beerling, E. (Evelyne), Heinz, M.C. (Maria C.), Postrach, D. (Daniel), Seinstra, D. (Danielle), Sieuwerts, A.M. (Anieta), Martens, J.W.M. (John), van der Elst, S. (Stefan), van Baalen, M. (Martijn), Bhowmick, D. (Debajit), Vrisekoop, N. (Nienke), Ellenbroek, S.I.J. (Saskia I J), Suijkerbuijk, S.J.E. (Saskia J E), Snippert, H.J. (Hugo J.), and van Rheenen, J. (Jacco)
- Abstract
Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a mouse model of colorectal cancer (CRC) and human tumor xenografts to investigate the cell of origin of metastases. We found that most disseminated CRC cells in circulation were Lgr5- and formed distant metastases in which Lgr5+ CSCs appeared. This pl
- Published
- 2020
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