1. A Novel Melanin-Targeted 18 F-PFPN Positron Emission Tomography Imaging for Diagnosing Ocular and Orbital Melanoma.
- Author
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Wang Y, Wang X, Zhang J, Zhang X, Cheng Y, and Jiang F
- Subjects
- Humans, Male, Middle Aged, Female, Adult, Retrospective Studies, Feasibility Studies, Picolinic Acids, Melanoma diagnostic imaging, Melanoma metabolism, Melanins metabolism, Radiopharmaceuticals, Positron-Emission Tomography methods, Orbital Neoplasms diagnostic imaging, Orbital Neoplasms metabolism, Fluorodeoxyglucose F18, Eye Neoplasms diagnostic imaging, Eye Neoplasms metabolism
- Abstract
Objective:
18 F-N-(2-(Diethylamino)ethyl)-5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy) picolinamide (18 F-PFPN) is a novel positron emission tomography (PET) probe designed to specifically targets melanin. This study aimed to evaluate the diagnostic feasibility of18 F-PFPN in patients with ocular or orbital melanoma., Materials and Methods: Three patients with pathologically confirmed ocular or orbital melanoma (one male, two females; age 41-59 years) were retrospectively reviewed. Each patient underwent comprehensive18 F-PFPN and18 F-fluorodeoxyglucose (18 F-FDG) PET scans. The maximum standardized uptake value (SUVmax ) of the lesion and the interference caused by background tissue were compared between18 F-PFPN and18 F-FDG PET imaging. In addition, the effect of intrinsic pigments in the uvea and retina on the interpretation of the results was examined. The contralateral non-tumorous eye of each patient served as a control., Results: All primary tumors (3/3) were detected using18 F-PFPN PET, while only two primary tumors were detected using18 F-FDG PET. Within each lesion, the SUVmax of18 F-PFPN was 2.6 to 8.3 times higher than that of18 F-FDG. Regarding the quality of PET imaging, the physiological uptake of18 F-FDG PET in the brain and periocular tissues limited the imaging of tumors. However,18 F-PFPN PET minimized this interference. Notably, intrinsic pigments in the uvea and retina did not cause abnormal concentrations of18 F-PFPN, as no anomalous uptake of18 F-PFPN was detected in the healthy contralateral eyes., Conclusion: Compared to18 F-FDG,18 F-PFPN demonstrated higher detection rates for ocular and orbital melanomas with minimal interference from surrounding tissues. This suggests that18 F-PFPN could be a promising clinical diagnostic tool for distinguishing malignant melanoma from benign pigmentation in ocular and orbital melanomas., Competing Interests: The authors have no potential conflicts of interest to disclose., (Copyright © 2024 The Korean Society of Radiology.)- Published
- 2024
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