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2. Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial

Author

Aghdami, Naser, Agüera-Morales, Eduardo, Ali, Rehiana, Allan, David, Arab, Leila, Battaglia, Mario, Berry, Isabelle, Blinkenberg, Morten, Bonetti, Bruno, Brundin, Lou, Capelli, Chiara, Castellan, Lucio, Cellerino, Maria, Cencioni, Maria Teresa, Clanet, Michel, Comi, Giancarlo, Courtman, David, Dazzi, Francesco, Fischer-Nielsen, Anne, Fernandez, Oscar, Fernandez, Victoria, Freedman, Mark S., Furlan, Roberto, Gimona, Mario, Gualandi, Francesca, Guan, Qingdong, Iacobaeus, Ellen, Inglese, Matilde, Introna, Martino, Izquierdo, Guillermo, Karimi, Shahedeh, Laroni, Alice, Le Blanc, Katarina, Loaiza, Sandra, Mallik, Shahrukh, Marley, Stephen, Marrie, Ruth Ann, Marriot, James, Martino, Gianvito, Nabavi, Seyed Massood, Miller, David, Muraro, Paolo A., Nicholas, Richard, Oliveri, Roberto S, Orengo, Giovanni, Palanicawande, Renuka, Pardini, Matteo, Radue, Ernst W, Ramo Tello, Cristina, Rush, Carolina, Schiavetti, Irene, Sellner, Johann, Sensebe, Luc, Soelberg Sorensen, Per, Sormani, Maria Pia, Strunk, Dirk, Szwajcer, David, Thalamas, Claire, Uccelli, Antonio, Wuerfel, Jens Thomas, Battaglia, Mario Alberto, Marriott, James, Muraro, Paolo, Radue, Ernst, Sorensen, Per Soelberg, and Freedman, Mark S

Published
2021
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4. Clinical characteristics, management and in-hospital mortality of patients with coronavirus disease 2019 in Genoa, Italy

Author

Alessandrini, Anna, Camera, Marco, Delfino, Emanuele, De Maria, Andrea, Dentone, Chiara, Di Biagio, Antonio, Dodi, Ferdinando, Ferrazin, Antonio, Mazzarello, Giovanni, Mikulska, Malgorzata, Nicolini, Laura, Toscanini, Federica, Giacobbe, Daniele R., Vena, Antonio, Taramasso, Lucia, Balletto, Elisa, Portunato, Federica, Schenone, Eva, Rosseti, Nirmala, Baldi, Federico, Berruti, Marco, Briano, Federica, Dettori, Silvia, Labate, Laura, Magnasco, Laura, Mirabella, Michele, Pincino, Rachele, russo, Chiara, Sarteschi, Giovanni, sepulcri, Chiara, Tutino, Stefania, Pontremoli, Roberto, Beccati, Valentina, Casciaro, Salvatore, Casu, Massimo, Gavaudan, Francesco, Ghinatti, Maria, Gualco, Elisa, Leoncini, Giovanna, pitto, Paola, salam, Kassem, Gratarola, Angelo, Bixio, Mattia, Amelia, Annalisa, Balestra, Andrea, Ballarino, Paola, Bardi, Nicholas, Boccafogli, Roberto, Caserza, Francesca, Calzolari, Elisa, Castelli, Marta, Cenni, Elisabetta, Cortese, Paolo, Cuttone, Giuseppe, Feltrin, Sara, Giovinazzo, Stefano, Giuntini, Patrizia, Natale, Letizia, Orsi, Davide, Pastorino, Matteo, Perazzo, Tommaso, Pescetelli, Fabio, Schenone, Federico, Serra, Maria G., Sottano, Marco, Tallone, Roberto, Amelotti, Massimo, Majabò, Marie J., Merlini, Massimo, Perazzo, Federica, Ahamd, Nidal, Barbera, Paolo, Bovio, Marta, Campodonico, Paola, Collidà, Andrea, Cutuli, Ombretta, Lomeo, Agnese, Fezza, Francesca, Gentilucci, Nicola, Hussein, Nadia, Malvezzi, Emanuele, Massobrio, Laura, Motta, Giula, Pastorino, Laura, Pollicardo, Nicoletta, Sartini, Stefano, Vacca, Paola, Virga, Valentina, Porto, Italo, Bezante, Giampaolo, Della Bona, Roberta, La Malfa, Giovanni, Valbusa, Alberto, Ad, Vered G., Barisione, Emanuela, Bellotti, Michele, Teresita, Aloe’, Blanco, Alessandro, Grosso, Marco, Piroddi, Maria Grazia, Moscatelli, Paolo, Caiti, Matteo, Magnani, Ottavia, Sukkar, Samir, Cogorno, Ludovica, Gradaschi, Raffaella, Guiddo, Erica, Martino, Eleonora, Pisciotta, Livia, Cavagliere, Bruno, Cristina, Rossi, Francesca, Farina, Garibotto, Giacomo, Esposito, Pasquale, Bellezza, Carmen, Harusha, Emirjona, Rossi, Francesca, Arboscello, Eleonora, Arzani, Laura, De Mattei, Laura, Spadaro, Marzia, Passalacqua, Giovanni, Bagnasco, Diego, Braido, Fulvio, Riccio, Annamaria, Tagliabue, Elena, Gustavino, Claudio, Ferraiolo, Antonella, Monacelli, Fiammetta, Mahmoud, Mona, Tagliafico, Luca, Napolitano, Armando, Fiorio, Maria, Pizzonia, Monica, Giannotti, Chiara, Nencioni, Alessio, Giuffrida, Salvatore, Rosso, Nicola, Morando, Alessandra, Papalia, Riccardo, Passerini, Donata, Tiberio, Gabriella, Orengo, Giovanni, Battaglini, Alberto, Ruffoni, Silvano, Caglieris, Sergio, Giacobbe, Daniele Roberto, Ball, Lorenzo, Brunetti, Iole, Loconte, Maurizio, Patroniti, Nicolò A., Robba, Chiara, Bavastro, Martina, Cerchiaro, Matteo, Giacomini, Mauro, Mora, Sara, Sepulcri, Chiara, Russo, Chiara, Pelosi, Paolo, and Bassetti, Matteo

Published
2020
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6. Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial

Author

Uccelli, Antonio, primary, Laroni, Alice, additional, Ali, Rehiana, additional, Battaglia, Mario Alberto, additional, Blinkenberg, Morten, additional, Brundin, Lou, additional, Clanet, Michel, additional, Fernandez, Oscar, additional, Marriott, James, additional, Muraro, Paolo, additional, Nabavi, Seyed Massood, additional, Oliveri, Roberto S, additional, Radue, Ernst, additional, Ramo Tello, Cristina, additional, Schiavetti, Irene, additional, Sellner, Johann, additional, Sorensen, Per Soelberg, additional, Sormani, Maria Pia, additional, Wuerfel, Jens Thomas, additional, Freedman, Mark S, additional, Aghdami, Naser, additional, Agüera-Morales, Eduardo, additional, Allan, David, additional, Arab, Leila, additional, Battaglia, Mario, additional, Berry, Isabelle, additional, Bonetti, Bruno, additional, Capelli, Chiara, additional, Castellan, Lucio, additional, Cellerino, Maria, additional, Cencioni, Maria Teresa, additional, Comi, Giancarlo, additional, Courtman, David, additional, Dazzi, Francesco, additional, Fischer-Nielsen, Anne, additional, Fernandez, Victoria, additional, Freedman, Mark S., additional, Furlan, Roberto, additional, Gimona, Mario, additional, Gualandi, Francesca, additional, Guan, Qingdong, additional, Iacobaeus, Ellen, additional, Inglese, Matilde, additional, Introna, Martino, additional, Izquierdo, Guillermo, additional, Karimi, Shahedeh, additional, Le Blanc, Katarina, additional, Loaiza, Sandra, additional, Mallik, Shahrukh, additional, Marley, Stephen, additional, Marrie, Ruth Ann, additional, Marriot, James, additional, Martino, Gianvito, additional, Miller, David, additional, Muraro, Paolo A., additional, Nicholas, Richard, additional, Orengo, Giovanni, additional, Palanicawande, Renuka, additional, Pardini, Matteo, additional, Radue, Ernst W, additional, Rush, Carolina, additional, Sensebe, Luc, additional, Soelberg Sorensen, Per, additional, Strunk, Dirk, additional, Szwajcer, David, additional, Thalamas, Claire, additional, and Uccelli, Antonio, additional

Published
2021
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7. Adherence to international and national recommendations for the prevention of surgical site infections in Italy: Results from an observational prospective study in elective surgery

Author

Durando, Paolo, Bassetti, Matteo, Orengo, Giovanni, Crimi, Paolo, Battistini, Angela, Bellina, Dorotea, Talamini, Antonella, Tiberio, Gabriella, Alicino, Cristiano, Iudici, Rocco, Sticchi, Camilla, Ansaldi, Filippo, Rossi, Anna, Rosso, Rita, Viscoli, Claudio, and Icardi, Giancarlo

Published
2012
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9. Clinical characteristics, management and in-hospital mortality of patients with coronavirus disease 2019 in Genoa, Italy

Author

Vena, Antonio, primary, Giacobbe, Daniele Roberto, additional, Di Biagio, Antonio, additional, Mikulska, Malgorzata, additional, Taramasso, Lucia, additional, De Maria, Andrea, additional, Ball, Lorenzo, additional, Brunetti, Iole, additional, Loconte, Maurizio, additional, Patroniti, Nicolò A., additional, Robba, Chiara, additional, Delfino, Emanuele, additional, Dentone, Chiara, additional, Magnasco, Laura, additional, Nicolini, Laura, additional, Toscanini, Federica, additional, Bavastro, Martina, additional, Cerchiaro, Matteo, additional, Barisione, Emanuela, additional, Giacomini, Mauro, additional, Mora, Sara, additional, Baldi, Federico, additional, Balletto, Elisa, additional, Berruti, Marco, additional, Briano, Federica, additional, Sepulcri, Chiara, additional, Dettori, Silvia, additional, Labate, Laura, additional, Mirabella, Michele, additional, Portunato, Federica, additional, Pincino, Rachele, additional, Russo, Chiara, additional, Tutino, Stefania, additional, Pelosi, Paolo, additional, Bassetti, Matteo, additional, Alessandrini, Anna, additional, Camera, Marco, additional, Dodi, Ferdinando, additional, Ferrazin, Antonio, additional, Mazzarello, Giovanni, additional, Giacobbe, Daniele R., additional, Vena, Antonio, additional, Schenone, Eva, additional, Rosseti, Nirmala, additional, russo, Chiara, additional, Sarteschi, Giovanni, additional, sepulcri, Chiara, additional, Pontremoli, Roberto, additional, Beccati, Valentina, additional, Casciaro, Salvatore, additional, Casu, Massimo, additional, Gavaudan, Francesco, additional, Ghinatti, Maria, additional, Gualco, Elisa, additional, Leoncini, Giovanna, additional, pitto, Paola, additional, salam, Kassem, additional, Gratarola, Angelo, additional, Bixio, Mattia, additional, Amelia, Annalisa, additional, Balestra, Andrea, additional, Ballarino, Paola, additional, Bardi, Nicholas, additional, Boccafogli, Roberto, additional, Caserza, Francesca, additional, Calzolari, Elisa, additional, Castelli, Marta, additional, Cenni, Elisabetta, additional, Cortese, Paolo, additional, Cuttone, Giuseppe, additional, Feltrin, Sara, additional, Giovinazzo, Stefano, additional, Giuntini, Patrizia, additional, Natale, Letizia, additional, Orsi, Davide, additional, Pastorino, Matteo, additional, Perazzo, Tommaso, additional, Pescetelli, Fabio, additional, Schenone, Federico, additional, Serra, Maria G., additional, Sottano, Marco, additional, Tallone, Roberto, additional, Amelotti, Massimo, additional, Majabò, Marie J., additional, Merlini, Massimo, additional, Perazzo, Federica, additional, Ahamd, Nidal, additional, Barbera, Paolo, additional, Bovio, Marta, additional, Campodonico, Paola, additional, Collidà, Andrea, additional, Cutuli, Ombretta, additional, Lomeo, Agnese, additional, Fezza, Francesca, additional, Gentilucci, Nicola, additional, Hussein, Nadia, additional, Malvezzi, Emanuele, additional, Massobrio, Laura, additional, Motta, Giula, additional, Pastorino, Laura, additional, Pollicardo, Nicoletta, additional, Sartini, Stefano, additional, Vacca, Paola, additional, Virga, Valentina, additional, Porto, Italo, additional, Bezante, Giampaolo, additional, Della Bona, Roberta, additional, La Malfa, Giovanni, additional, Valbusa, Alberto, additional, Ad, Vered G., additional, Bellotti, Michele, additional, Teresita, Aloe’, additional, Blanco, Alessandro, additional, Grosso, Marco, additional, Piroddi, Maria Grazia, additional, Moscatelli, Paolo, additional, Caiti, Matteo, additional, Magnani, Ottavia, additional, Sukkar, Samir, additional, Cogorno, Ludovica, additional, Gradaschi, Raffaella, additional, Guiddo, Erica, additional, Martino, Eleonora, additional, Pisciotta, Livia, additional, Cavagliere, Bruno, additional, Cristina, Rossi, additional, Francesca, Farina, additional, Garibotto, Giacomo, additional, Esposito, Pasquale, additional, Bellezza, Carmen, additional, Harusha, Emirjona, additional, Rossi, Francesca, additional, Arboscello, Eleonora, additional, Arzani, Laura, additional, De Mattei, Laura, additional, Spadaro, Marzia, additional, Passalacqua, Giovanni, additional, Bagnasco, Diego, additional, Braido, Fulvio, additional, Riccio, Annamaria, additional, Tagliabue, Elena, additional, Gustavino, Claudio, additional, Ferraiolo, Antonella, additional, Monacelli, Fiammetta, additional, Mahmoud, Mona, additional, Tagliafico, Luca, additional, Napolitano, Armando, additional, Fiorio, Maria, additional, Pizzonia, Monica, additional, Giannotti, Chiara, additional, Nencioni, Alessio, additional, Giuffrida, Salvatore, additional, Rosso, Nicola, additional, Morando, Alessandra, additional, Papalia, Riccardo, additional, Passerini, Donata, additional, Tiberio, Gabriella, additional, Orengo, Giovanni, additional, Battaglini, Alberto, additional, Ruffoni, Silvano, additional, and Caglieris, Sergio, additional

Published
2020
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10. Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems

Author

Barisione, Emanuela, primary, Grillo, Federica, additional, Ball, Lorenzo, additional, Bianchi, Rita, additional, Grosso, Marco, additional, Morbini, Patrizia, additional, Pelosi, Paolo, additional, Patroniti, Nicolò Antonino, additional, De Lucia, Arduino, additional, Orengo, Giovanni, additional, Gratarola, Angelo, additional, Verda, Marta, additional, Cittadini, Giuseppe, additional, Mastracci, Luca, additional, and Fiocca, Roberto, additional

Published
2020
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13. How to Prioritise and Optimise Access to Elective Surgery in the COVID-19 Pandemic: An Interhospital Alliance Pathway Based on the SWALIS 2020 Model. A Single-Cohort Feasibility & Pilot Study

Author

Valente, Roberto, primary, Domenico, Stefano Di, additional, Mascherini, Matteo, additional, Santori, Gregorio, additional, Papadia, Francesco, additional, Orengo, Giovanni, additional, Gratarola, Angelo, additional, Cafiero, Ferdinando, additional, and Cian, Franco De, additional

Published
2020
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14. Histopathologic Progression and Radiologic Correlation of COVID-19 Lung Parenchyma Using a Post-Mortem Mini-Invasive Transbronchial Lung Cryobiopsy Approach

Author

Barisione, Emanuela, primary, Grillo, Federica, additional, Ball, Lorenzo, additional, Bianchi, Rita, additional, Grosso, Marco, additional, Pelosi, Paolo, additional, Patroniti, Nicolò, additional, Lucia, Arduino De, additional, Orengo, Giovanni, additional, Gratarola, Angelo, additional, Verda, Marta, additional, Cittadini, Giuseppe, additional, Mastracci, Luca, additional, and Fiocca, Roberto, additional

Published
2020
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18. Latent Tuberculosis Infection among a Large Cohort of Medical Students at a Teaching Hospital in Italy

Author

Durando, Paolo, primary, Alicino, Cristiano, additional, Orsi, Andrea, additional, Barberis, Ilaria, additional, Paganino, Chiara, additional, Dini, Guglielmo, additional, Mazzarello, Giovanni, additional, Del Bono, Valerio, additional, Viscoli, Claudio, additional, Copello, Francesco, additional, Sossai, Dimitri, additional, Orengo, Giovanni, additional, Sticchi, Laura, additional, Ansaldi, Filippo, additional, and Icardi, Giancarlo, additional

Published
2015
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21. Enhanced patient journey associated with improved overall survival in colon cancer patients: A study by the Ligurian Oncology Network.

Author

Boutros A, Diaz Gaitan NS, Orengo G, Blondeaux E, Pastorino A, Zacconi M, Ferrè F, Boni L, Cardinali B, and Del Mastro L

Abstract

Background: Colon cancer imposes a significant burden on global healthcare systems, necessitating efforts to improve oncology care quality and patient outcomes. We studied the correlation between care quality and survival outcomes among colon cancer patients within the Ligurian Oncology Network (Italy)., Methods: We developed an Overall Quality Score (OQS) to evaluate the impact of oncology care quality on survival outcomes within the Ligurian Oncology Network. OQS indicators were selected through expert consensus, covering screening, diagnosis, treatment, and follow-up. A sample of colon cancer patients diagnosed in 2012 was randomly selected from administrative healthcare data. Analyses were performed using two models: a binary model (High and Low OQS) and a stratified model (Low, Medium, and High OQS). Statistical analysis involved survival curves, log-rank tests, and Cox proportional hazards models using SAS 9.4., Results: Of 175 eligible colon cancer patients, 150 were included. Following a median follow-up of 7.6 years, a correlation between High-OQS (⩾ 65%) and prolonged disease-free survival was observed (unadjusted HR 0.57, 95%CI 0.33-0.99, log-rank p=0.041). The five-year disease-free survival rate for High-OQS patients was 70% (95%CI 57-80%), compared to 53% (95%CI 41-64%) for Low-OQS patients. Similarly, the five-year overall survival rate was 78% (95%CI 65-86%) for High-OQS patients, compared to 58% (95%CI 45-68%) for Low-OQS patients (unadjusted HR 0.56, 95%CI 0.31-1.00, log-rank p=0.048)., Conclusions: Our findings highlight the potential impact of the patient journey on colon cancer survival outcomes. Optimising care pathways might improve patient outcomes in colon cancer management., Competing Interests: Declaration of conflicting interestThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: All the disclosed activities are outside the submitted work. EB reports research funding to their institution from Gilead, speaker fee from Eli Lilly. LDM reports institutional grants from Eli Lilly, Novartis, Roche, Daiichi Sankyo, Seagen, Astrazeneca, Gilead, Pierre Fabre; consulting fees: Eli Lilly, Gilead, Daiichi Sankyio; payment or honoraria for lectures, presentations, speakers bureaus: Roche, Novartis, Pfizer, Eli Lilly, Astrazeneca, MSD, Seagen, Gilead, Pierre Fabre, Eisai, Exact Sciences, Ipsen, GSK, Agendia, Stemline; support for attending meetings and/or travel: Roche, Pfizer, Eisai, Daiichi Sankyo, Astrazeneca, Gilead; Participation on a Data Safety Monitoring Board or Advisory Board: Novartis, Roche, Eli Lilly, Pfizer, Daiichi Sakyo, Exact Sciences, Gilead, Pierre Fabre, Eisai, Astrazeneca, Agendia, GSK, Seagen, Olema, MSD, Stemline Menarini. All other authors have no competing interests to declare.

Published
2024
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22. Monitoring emergency and urgent surgery: an improvement in a Healthcare Management Unit at a third-level hospital in Italy.

Author

Inglese L, Barberis I, Korshunova M, Amato R, Zangrillo F, Arata L, Tisa V, Papalia R, Santo M, Tiberio G, Morando A, and Orengo G

Subjects
Humans, Italy, Surgical Procedures, Operative, Emergencies, Emergency Service, Hospital
Abstract

Introduction: At San Martino IRCCS Hospital in Genoa, Italy, emergency and urgent surgery is classified according to the National Confidential Enquiry into Patient Outcome and Death (NCEPOD) classification, whereby cases are divided into two categories and colour-coded accordingly: - EMERGENCY - (Colour-code: RED) "Surgery to be performed within minutes"; - URGENCY - (colour-code: YELLOW) "Surgery to be performed within hours". In this context, it is essential that the emergency surgical team gets clear and complete information from the proposing surgeon, in order to complete the surgical list., Methods: Between 14 th April 2023 and 23 th July 2023, a new method of requesting urgent and emergency surgery by filling out an online form was tested., Results: A total of 406 online requests were made, resulting in 367 E/U surgeries. The greatest number of emergency operations concerned thoracic-abdominal surgery (45%), followed by urology (19%). The requests analysed classified 18% of cases as red and 71% as yellow. The remaining 11% contained compilation errors. Moreover, 11% of the interventions were not performed within the time limits defined according to the severity code., Conclusions: By means of this new tool, San Martino IRCCS Hospital's Healthcare Management Unit can monitor requests for surgery in real time, thereby achieving greater efficiency and implementing corrective measures in the use of Operating Room resources., Competing Interests: None declared., (©2024 Pacini Editore SRL, Pisa, Italy.)

Published
2024
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23. Adherence to international and national recommendations for the prevention of surgical site infections in Italy: results from an observational prospective study in elective surgery.

Author

Durando P, Bassetti M, Orengo G, Crimi P, Battistini A, Bellina D, Talamini A, Tiberio G, Alicino C, Iudici R, Sticchi C, Ansaldi F, Rossi A, Rosso R, Viscoli C, and Icardi G

Subjects
Elective Surgical Procedures adverse effects, Humans, Italy epidemiology, Prospective Studies, Surgical Wound Infection epidemiology, Tertiary Care Centers, Guideline Adherence statistics & numerical data, Preoperative Care methods, Surgical Wound Infection prevention & control
Abstract

Background: An observational prospective study of the perioperative procedures for prevention of surgical site infections (SSIs) was carried out in a tertiary referral teaching hospital in Liguria, Italy, to evaluate their adherence to international and national standards., Methods: A 1-month survey was performed in all surgical departments, monitored by turns by trained survey teams. Data regarding presurgical patient preparation and intraoperative infection control practices were collected., Results: A total of 717 elective interventions were actively monitored in 703 patients who underwent surgery. Hair-shaving was performed mainly using a razor (92%) by the nurses (72.8%) on the day before the operation (83.5%). All of the patients showered, either with a common detergent (87%) or with an antiseptic solution (13%). Antimicrobial prophylaxis was administered properly in 75.7% of the patients at induction of anaesthesia; however, according to current Italian guidelines, inappropriate prophylaxis was provided in 55.2% patients. Appropriate antisepsis of the incision area was done in 97.4% of the operations, and nearly 90% of the interventions lasted less than the respective 75th percentile. The doors of the operating theatres were mostly open during the duration of the operation in 36.3% of the cases., Conclusions: This review of infection control policies identified significant opportunities for improving the safety and the quality of routine surgical practice., (Copyright © 2012 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.)

Published
2012
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