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1. Increases in symptoms of depression and anxiety in adults during the initial phases of the COVID-19 pandemic are limited to those with less resources: Results from the Lifelines Cohort Study

Author

Boezen, H.M., Mierau, J.O., Franke, H.L., Dekens, J., Deelen, P., Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X.L., Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., Qi, Yuwei, Lepe, Alexander, Almansa, Josué, Ots, Patricia, de Kroon, Marlou L.A., Vrooman, J. Cok, Reijneveld, Sijmen A., and Brouwer, Sandra

Published
2022
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4. Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk

Author

Onderzoeksgroep 11, Brain, Hersenen-Bedrijfsvoering, Ori, Anil P.S., Olde Loohuis, Loes M., Guintivano, Jerry, Hannon, Eilis, Dempster, Emma, St. Clair, David, Bass, Nick J., McQuillin, Andrew, Mill, Jonathan, Sullivan, Patrick F., Kahn, Rene S., Horvath, Steve, Ophoff, Roel A., Onderzoeksgroep 11, Brain, Hersenen-Bedrijfsvoering, Ori, Anil P.S., Olde Loohuis, Loes M., Guintivano, Jerry, Hannon, Eilis, Dempster, Emma, St. Clair, David, Bass, Nick J., McQuillin, Andrew, Mill, Jonathan, Sullivan, Patrick F., Kahn, Rene S., Horvath, Steve, and Ophoff, Roel A.

Published
2024

5. Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk

Author

Ori, Anil P.S., Olde Loohuis, Loes M., Guintivano, Jerry, Hannon, Eilis, Dempster, Emma, St. Clair, David, Bass, Nick J., McQuillin, Andrew, Mill, Jonathan, Sullivan, Patrick F., Kahn, Rene S., Horvath, Steve, Ophoff, Roel A., Ori, Anil P.S., Olde Loohuis, Loes M., Guintivano, Jerry, Hannon, Eilis, Dempster, Emma, St. Clair, David, Bass, Nick J., McQuillin, Andrew, Mill, Jonathan, Sullivan, Patrick F., Kahn, Rene S., Horvath, Steve, and Ophoff, Roel A.

Abstract

Background: The study of biological age acceleration may help identify at-risk individuals and reduce the rising global burden of age-related diseases. Using DNA methylation (DNAm) clocks, we investigated biological aging in schizophrenia (SCZ), a mental illness that is associated with an increased prevalence of age-related disabilities and morbidities. In a whole blood DNAm sample of 1090 SCZ cases and 1206 controls across four European cohorts, we performed a meta-analysis of differential aging using three DNAm clocks (i.e., Hannum, Horvath, and Levine). To dissect how DNAm aging contributes to SCZ, we integrated information on duration of illness and SCZ polygenic risk, as well as stratified our analyses by chronological age and biological sex. Results: We found that blood-based DNAm aging is significantly altered in SCZ independent from duration of the illness since onset. We observed sex-specific and nonlinear age effects that differed between clocks and point to possible distinct age windows of altered aging in SCZ. Most notably, intrinsic cellular age (Horvath clock) is decelerated in SCZ cases in young adulthood, while phenotypic age (Levine clock) is accelerated in later adulthood compared to controls. Accelerated phenotypic aging was most pronounced in women with SCZ carrying a high polygenic burden with an age acceleration of + 3.82 years (CI 2.02–5.61, P = 1.1E−03). Phenotypic aging and SCZ polygenic risk contributed additively to the illness and together explained up to 14.38% of the variance in disease status. Conclusions: Our study contributes to the growing body of evidence of altered DNAm aging in SCZ and points to intrinsic age deceleration in younger adulthood and phenotypic age acceleration in later adulthood in SCZ. Since increased phenotypic age is associated with increased risk of all-cause mortality, our findings indicate that specific and identifiable patient groups are at increased mortality risk as measured by the Levine clock. Our stud

Published
2024

6. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

Author

Byrne, Enda M., Forstner, Andreas J., Holmans, Peter A., de Leeuw, Christiaan A., Mattheisen, Manuel, McQuillin, Andrew, Whitehead Pavlides, Jennifer M., Pers, Tune H., Ripke, Stephan, Stahl, Eli A., Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng, Abbott, Liam, Abdellaoui, Abdel, Adams, Mark J., Adolfsson, Annelie Nordin, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Andlauer, Till F.M., Anjorin, Adebayo, Antilla, Verneri, Van der Auwera, Sandra, Awasthi, Swapnil, Bacanu, Silviu-Alin, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Beekman, Aartjan T.F., Belliveau, Richard, Bergen, Sarah E., Bigdeli, Tim B., Binder, Elisabeth B., Bøen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Byerley, William, Cai, Na, Casas, Miquel, Castelao, Enrique, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W., Chen, Danfeng, Christensen, Jane Hvarregaard, Churchhouse, Claire, St Clair, David, Clarke, Toni-Kim, Colodro-Conde, Lucía, Coryell, William, Couvy-Duchesne, Baptiste, Craig, David W., Crawford, Gregory E., Cruceanu, Cristiana, Czerski, Piotr M., Dale, Anders M., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J Raymond, Derks, Eske M., Direk, Nese, Djurovic, Srdjan, Dobbyn, Amanda L., Dolan, Conor V., Dumont, Ashley, Dunn, Erin C., Eley, Thalia C., Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Finucane, Hilary K., Fischer, Sascha B., Flickinger, Matthew, Foo, Jerome C., Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Goes, Fernando S., Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grove, Jakob, Guan, Weihua, Hall, Lynsey S., Hamshere, Marian L., Hansen, Christine Søholm, Hansen, Thomas F., Hautzinger, Martin, Heilbronner, Urs, van Hemert, Albert M., Herms, Stefan, Hickie, Ian B., Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Huckins, Laura, Ising, Marcus, Jamain, Stéphane, Jansen, Rick, Johnson, Jessica S., de Jong, Simone, Jorgenson, Eric, Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Hassan Kiadeh, Farnush Farhadi, Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Kohane, Isaac S., Koller, Anna C., Kraft, Julia, Kretzschmar, Warren W., Krogh, Jesper, Kupka, Ralph, Kutalik, Zoltán, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Li, Yihan, Lind, Penelope A., Liu, Chunyu, Olde Loohuis, Loes M., Maaser, Anna, MacIntyre, Donald J., MacKinnon, Dean F., Mahon, Pamela B., Maier, Wolfgang, Maier, Robert M., Marchini, Jonathan, Martinsson, Lina, Mbarek, Hamdi, McCarroll, Steve, McGrath, Patrick, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Mehta, Divya, Meng, Fan, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mirza, Saira Saeed, Mondimore, Francis M., Montgomery, Grant W., Morris, Derek W., Mostafavi, Sara, Mühleisen, Thomas W., Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nguyen, Hoang, Nievergelt, Caroline M., Nivard, Michel G., Nwulia, Evaristus A., Nyholt, Dale R., O'Donovan, Claire, O'Reilly, Paul F., Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Oskarsson, Hogni, Painter, Jodie N., Parra, José Guzman, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Perry, Amy, Peterson, Roseann E., Pettersson, Erik, Peyrot, Wouter J., Pfennig, Andrea, Pistis, Giorgio, Purcell, Shaun M., Quiroz, Jorge A., Qvist, Per, Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Riley, Brien P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schoevers, Robert, Schork, Nicholas J., Schulte, Eva C., Shehktman, Tatyana, Shen, Ling, Shi, Jianxin, Shilling, Paul D., Shyn, Stanley I., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B., Smit, Johannes H., Smith, Daniel J., Sobell, Janet L., Spijker, Anne T., Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Robert C., Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Uitterlinden, André G., Umbricht, Daniel, Vedder, Helmut, Viktorin, Alexander, Visscher, Peter M., Wang, Weiqing, Watson, Stanley J., Webb, Bradley T., Weickert, Cynthia Shannon, Weickert, Thomas W., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Xu, Wei, Yang, Jian, Young, Allan H., Zandi, Peter, Zhang, Peng, Zhang, Futao, Zollner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Arolt, Volker, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berger, Klaus, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Boomsma, Dorret I., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., de Geus, E.J.C., Gill, Michael, Goes, Fernando, Grabe, Hans J., Grigoroiu-Serbanescu, Maria, Hamilton, Steven P., Hauser, Joanna, Hayward, Caroline, Heath, Andrew C., Hougaard, David M., Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, René S., Kendler, Kenneth S., Kirov, George, Kloiber, Stefan, Landén, Mikael, Leboyer, Marion, Lewis, Glyn, Li, Qingqin S., Lissowska, Jolanta, Lucae, Susanne, Madden, Pamela A.F., Magnusson, Patrik K., Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C., Oedegaard, Ketil J., Owen, Michael J., Paciga, Sara A., Pato, Carlos, Pato, Michele T., Pedersen, Nancy L., Penninx, Brenda W.J. H., Perlis, Roy H., Porteous, David J., Posthuma, Danielle, Potash, James B., Preisig, Martin, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A., Schaefer, Catherine, Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Tiemeier, Henning, Turecki, Gustavo, Uher, Rudolf, Vaaler, Arne E., Vieta, Eduard, Vincent, John B., Völzke, Henry, Weissman, Myrna M., Werge, Thomas, Andreassen, Ole A., Børglum, Anders D., Cichon, Sven, Edenberg, Howard J., Di Florio, Arianna, Kelsoe, John, Levinson, Douglas F., Lewis, Cathryn M., Nurnberger, John I., Ophoff, Roel A., Scott, Laura J., Sklar, Pamela, Sullivan, Patrick F., Wray, Naomi R., Coleman, Jonathan R.I., Gaspar, Héléna A., Bryois, Julien, and Breen, Gerome

Published
2020
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9. Workplace impact on employees: A Lifelines Corona Research Initiative on the return to work

Author

Mobach, Mark P., Boezen, H. M, Mierau, Jochen O., Franke, H. Lude, Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X.L., Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., van Blokland, Irene, de Bock, Geer Truida H., Rosmalen, Judith G.M., Wijmenga, Cisca, Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), Research programme EEF, Faculteit Medische Wetenschappen/UMCG, Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)

Abstract

A large proportion of the global workforce migrated home during the COVID-19 pandemic and subsequent lockdowns. It remains unclear what the exact differences between home workers and non-home workers were, especially during the pandemic when a return to work was imminent. How were building, workplace, and related facilities associated with workers’ perceptions and health? What are the lessons to be learned? Lifelines Corona Research Initiative was used to compare employees’ workplaces and related concerns, facilities, work quality, and health in a complete case analysis (N = 12,776) when return to work was imminent. Mann-Whitney U, logistic regression, and Wilcoxon matched-pairs were used for analyses. Notwithstanding small differences, the results show that home workers had less favourable scores for concerns about and facilities of on-site buildings and workplaces upon return to work, but better scores for work quality and health than non-home workers. However, additional analyses also suggest that building, workplace, and related facilities may have had the capacity to positively influence employees’ affective responses and work quality, but not always their health.

Published
2023

10. Increases in symptoms of depression and anxiety in adults during the initial phases of the COVID-19 pandemic are limited to those with less resources: Results from the Lifelines Cohort Study

Author

Qi, Yuwei, primary, Lepe, Alexander, additional, Almansa, Josué, additional, Ots, Patricia, additional, de Kroon, Marlou L.A., additional, Vrooman, J. Cok, additional, Reijneveld, Sijmen A., additional, Brouwer, Sandra, additional, Boezen, H.M., additional, Mierau, J.O., additional, Franke, H.L., additional, Dekens, J., additional, Deelen, P., additional, Lanting, Pauline, additional, Vonk, Judith M., additional, Nolte, Ilja, additional, Ori, Anil P.S., additional, Claringbould, Annique, additional, Boulogne, Floranne, additional, Dijkema, Marjolein X.L., additional, Wiersma, Henry H., additional, Warmerdam, Robert, additional, and Jankipersadsing, Soesma A., additional

Published
2022
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11. Significant variation in the performance of DNA methylation predictors across data preprocessing and normalization strategies

Author

Ori, Anil P.S., Lu, Ake T., Horvath, Steve, Ophoff, Roel A., Ori, Anil P.S., Lu, Ake T., Horvath, Steve, and Ophoff, Roel A.

Abstract

Background: DNA methylation (DNAm)-based predictors hold great promise to serve as clinical tools for health interventions and disease management. While these algorithms often have high prediction accuracy, the consistency of their performance remains to be determined. We therefore conduct a systematic evaluation across 101 different DNAm data preprocessing and normalization strategies and assess how each analytical strategy affects the consistency of 41 DNAm-based predictors. Results: Our analyses are conducted in a large EPIC DNAm array dataset from the Jackson Heart Study (N = 2053) that included 146 pairs of technical replicate samples. By estimating the average absolute agreement between replicate pairs, we show that 32 out of 41 predictors (78%) demonstrate excellent consistency when appropriate data processing and normalization steps are implemented. Across all pairs of predictors, we find a moderate correlation in performance across analytical strategies (mean rho = 0.40, SD = 0.27), highlighting significant heterogeneity in performance across algorithms. Successful or unsuccessful removal of technical variation furthermore significantly impacts downstream phenotypic association analysis, such as all-cause mortality risk associations. Conclusions: We show that DNAm-based algorithms are sensitive to technical variation. The right choice of data processing strategy is important to achieve reproducible estimates and improve prediction accuracy in downstream phenotypic association analyses. For each of the 41 DNAm predictors, we report its degree of consistency and provide the best performing analytical strategy as a guideline for the research community. As DNAm-based predictors become more and more widely used, our work helps improve their performance and standardize their implementation.

Published
2022

12. Frailty and risk of hospitalization from COVID-19 infection among older adults : evidence from the Dutch Lifelines COVID-19 Cohort study

Author

Zhu, Yinjie, Sealy, Martine J., Jager-Wittenaar, Harriët, Mierau, Jochen O., Bakker, Stephan J.L., Navis, Gerjan J., Boezen, H.M., Franke, H.L., Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X.L., Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., van Blokland, Irene, de Bock, Geertruida H., Rosmalen, Judith G.M., Wijmenga, Cisca, Zhu, Yinjie, Sealy, Martine J., Jager-Wittenaar, Harriët, Mierau, Jochen O., Bakker, Stephan J.L., Navis, Gerjan J., Boezen, H.M., Franke, H.L., Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X.L., Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., van Blokland, Irene, de Bock, Geertruida H., Rosmalen, Judith G.M., and Wijmenga, Cisca

Abstract

Background: Frailty is associated with COVID-19 severity in clinical settings. No general population-based studies on the association between actual frailty status and COVID-19 hospitalization are available. Aims: To investigate the association between frailty and the risk of COVID-19 hospitalization once infected. Methods: 440 older adults who participated in the Lifelines COVID-19 Cohort study in the Northern Netherlands and reported positive COVID-19 testing results (54.2% women, age 70 ± 4 years in 2021) were included in the analyses. COVID-19 hospitalization status was self-reported. The Groningen Frailty Indicator (GFI) was derived from 15 self-reported questionnaire items related to daily activities, health problems, and psychosocial functioning, with a score ≥ 4 indicating frailty. Both frailty and COVID-19 hospitalization were assessed in the same period. Poisson regression models with robust standard errors were used to analyze the associations between frailty and COVID-19 hospitalization. Results: Of 440 older adults included, 42 were hospitalized because of COVID-19 infection. After adjusting for sociodemographic and lifestyle factors, a higher risk of COVID-19 hospitalization was observed for frail individuals (risk ratio (RR) [95% CI] 1.97 [1.06–3.67]) compared to those classified as non-frail. Discussion: Frailty was positively associated with COVID-19 hospitalization once infected, independent of sociodemographic and lifestyle factors. Future research on frailty and COVID-19 should consider biomarkers of aging and frailty to understand the pathophysiological mechanisms and manifestations between frailty and COVID-19 outcomes. Conclusions: Frailty was positively associated with the risk of hospitalization among older adults that were infected with COVID-19. Public health strategies for frailty prevention in older adults need to be advocated, as it is helpful to reduce the burden of the healthcare system, particularly during a pandemic like COVID-19.

Published
2022

13. Impact of the COVID-19 pandemic on adults with moderate-to-severe atopic dermatitis in the Dutch general population

Author

Zhang, Junfen, Loman, Laura, Kamphuis, Esmé, Schuttelaar, Marie L A, Boezen, H. M., Mierau, Jochen, Franke, H. Lude, Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja M., Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X L, Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., van Blokland, Irene, Public Health Research (PHR), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), Research programme EEF, Stem Cell Aging Leukemia and Lymphoma (SALL), and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Subjects
atopic dermatitis, RL1-803, atopic eczema, COVID-19, disease severity, epidemiology, Dermatology, general population, Article
Published
2022

14. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Author

Blokland, Gabriëlla A.M., primary, Grove, Jakob, additional, Chen, Chia-Yen, additional, Cotsapas, Chris, additional, Tobet, Stuart, additional, Handa, Robert, additional, St Clair, David, additional, Lencz, Todd, additional, Mowry, Bryan J., additional, Periyasamy, Sathish, additional, Cairns, Murray J., additional, Tooney, Paul A., additional, Wu, Jing Qin, additional, Kelly, Brian, additional, Kirov, George, additional, Sullivan, Patrick F., additional, Corvin, Aiden, additional, Riley, Brien P., additional, Esko, Tõnu, additional, Milani, Lili, additional, Jönsson, Erik G., additional, Palotie, Aarno, additional, Ehrenreich, Hannelore, additional, Begemann, Martin, additional, Steixner-Kumar, Agnes, additional, Sham, Pak C., additional, Iwata, Nakao, additional, Weinberger, Daniel R., additional, Gejman, Pablo V., additional, Sanders, Alan R., additional, Buxbaum, Joseph D., additional, Rujescu, Dan, additional, Giegling, Ina, additional, Konte, Bettina, additional, Hartmann, Annette M., additional, Bramon, Elvira, additional, Murray, Robin M., additional, Pato, Michele T., additional, Lee, Jimmy, additional, Melle, Ingrid, additional, Molden, Espen, additional, Ophoff, Roel A., additional, McQuillin, Andrew, additional, Bass, Nicholas J., additional, Adolfsson, Rolf, additional, Malhotra, Anil K., additional, Martin, Nicholas G., additional, Fullerton, Janice M., additional, Mitchell, Philip B., additional, Schofield, Peter R., additional, Forstner, Andreas J., additional, Degenhardt, Franziska, additional, Schaupp, Sabrina, additional, Comes, Ashley L., additional, Kogevinas, Manolis, additional, Guzman-Parra, José, additional, Reif, Andreas, additional, Streit, Fabian, additional, Sirignano, Lea, additional, Cichon, Sven, additional, Grigoroiu-Serbanescu, Maria, additional, Hauser, Joanna, additional, Lissowska, Jolanta, additional, Mayoral, Fermin, additional, Müller-Myhsok, Bertram, additional, Świątkowska, Beata, additional, Schulze, Thomas G., additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Kelsoe, John, additional, Leboyer, Marion, additional, Jamain, Stéphane, additional, Etain, Bruno, additional, Bellivier, Frank, additional, Vincent, John B., additional, Alda, Martin, additional, O’Donovan, Claire, additional, Cervantes, Pablo, additional, Biernacka, Joanna M., additional, Frye, Mark, additional, McElroy, Susan L., additional, Scott, Laura J., additional, Stahl, Eli A., additional, Landén, Mikael, additional, Hamshere, Marian L., additional, Smeland, Olav B., additional, Djurovic, Srdjan, additional, Vaaler, Arne E., additional, Andreassen, Ole A., additional, Baune, Bernhard T., additional, Air, Tracy, additional, Preisig, Martin, additional, Uher, Rudolf, additional, Levinson, Douglas F., additional, Weissman, Myrna M., additional, Potash, James B., additional, Shi, Jianxin, additional, Knowles, James A., additional, Perlis, Roy H., additional, Lucae, Susanne, additional, Boomsma, Dorret I., additional, Penninx, Brenda W.J.H., additional, Hottenga, Jouke-Jan, additional, de Geus, Eco J.C., additional, Willemsen, Gonneke, additional, Milaneschi, Yuri, additional, Tiemeier, Henning, additional, Grabe, Hans J., additional, Teumer, Alexander, additional, Van der Auwera, Sandra, additional, Völker, Uwe, additional, Hamilton, Steven P., additional, Magnusson, Patrik K.E., additional, Viktorin, Alexander, additional, Mehta, Divya, additional, Mullins, Niamh, additional, Adams, Mark J., additional, Breen, Gerome, additional, McIntosh, Andrew M., additional, Lewis, Cathryn M., additional, Hougaard, David M., additional, Nordentoft, Merete, additional, Mors, Ole, additional, Mortensen, Preben B., additional, Werge, Thomas, additional, Als, Thomas D., additional, Børglum, Anders D., additional, Petryshen, Tracey L., additional, Smoller, Jordan W., additional, Goldstein, Jill M., additional, Ripke, Stephan, additional, Neale, Benjamin M., additional, Walters, James T.R., additional, Farh, Kai-How, additional, Holmans, Peter A., additional, Lee, Phil, additional, Bulik-Sullivan, Brendan, additional, Collier, David A., additional, Huang, Hailiang, additional, Pers, Tune H., additional, Agartz, Ingrid, additional, Agerbo, Esben, additional, Albus, Margot, additional, Alexander, Madeline, additional, Amin, Farooq, additional, Bacanu, Silviu A., additional, Belliveau, Richard A., additional, Bene, Judit, additional, Bergen, Sarah E., additional, Bevilacqua, Elizabeth, additional, Bigdeli, Tim B., additional, Black, Donald W., additional, Bruggeman, Richard, additional, Buccola, Nancy G., additional, Buckner, Randy L., additional, Byerley, William, additional, Cahn, Wiepke, additional, Cai, Guiqing, additional, Campion, Dominique, additional, Cantor, Rita M., additional, Carr, Vaughan J., additional, Carrera, Noa, additional, Catts, Stanley V., additional, Chambert, Kimberly D., additional, Chan, Raymond C.K., additional, Chen, Ronald Y.L., additional, Chen, Eric Y.H., additional, Cheng, Wei, additional, Cheung, Eric F.C., additional, Chong, Siow Ann, additional, Cloninger, C. Robert, additional, Cohen, David, additional, Cohen, Nadine, additional, Cormican, Paul, additional, Craddock, Nick, additional, Crowley, James J., additional, Curtis, David, additional, Davidson, Michael, additional, Davis, Kenneth L., additional, Del Favero, Jurgen, additional, Demontis, Ditte, additional, Dikeos, Dimitris, additional, Dinan, Timothy, additional, Donohoe, Gary, additional, Drapeau, Elodie, additional, Duan, Jubao, additional, Dudbridge, Frank, additional, Durmishi, Naser, additional, Eichhammer, Peter, additional, Eriksson, Johan, additional, Escott-Price, Valentina, additional, Essioux, Laurent, additional, Fanous, Ayman H., additional, Farrell, Martilias S., additional, Frank, Josef, additional, Franke, Lude, additional, Freedman, Robert, additional, Freimer, Nelson B., additional, Friedl, Marion, additional, Friedman, Joseph I., additional, Fromer, Menachem, additional, Genovese, Giulio, additional, Georgieva, Lyudmila, additional, Giusti-Rodríguez, Paola, additional, Godard, Stephanie, additional, Goldstein, Jacqueline I., additional, Golimbet, Vera, additional, Gopal, Srihari, additional, Gratten, Jacob, additional, de Haan, Lieuwe, additional, Hammer, Christian, additional, Hansen, Mark, additional, Hansen, Thomas, additional, Haroutunian, Vahram, additional, Henskens, Frans A., additional, Herms, Stefan, additional, Hirschhorn, Joel N., additional, Hoffmann, Per, additional, Hofman, Andrea, additional, Hollegaard, Mads V., additional, Ikeda, Masashi, additional, Joa, Inge, additional, Julià, Antonio, additional, Kahn, René S., additional, Kalaydjieva, Luba, additional, Karachanak-Yankova, Sena, additional, Karjalainen, Juha, additional, Kavanagh, David, additional, Keller, Matthew C., additional, Kennedy, James L., additional, Khrunin, Andrey, additional, Kim, Yunjung, additional, Klovins, Janis, additional, Kucinskas, Vaidutis, additional, Kucinskiene, Zita Ausrele, additional, Kuzelova-Ptackova, Hana, additional, Kähler, Anna K., additional, Laurent, Claudine, additional, Lee Chee Keong, Jimmy, additional, Lee, S. Hong, additional, Legge, Sophie E., additional, Lerer, Bernard, additional, Li, Miaoxin, additional, Li, Tao, additional, Liang, Kung-Yee, additional, Lieberman, Jeffrey, additional, Limborska, Svetlana, additional, Loughland, Carmel M., additional, Lubinski, Jan, additional, Lönnqvist, Jouko, additional, Macek, Milan, additional, Maher, Brion S., additional, Maier, Wolfgang, additional, Mallet, Jacques, additional, Marsal, Sara, additional, Mattheisen, Manuel, additional, Mattingsdal, Morten, additional, McCarley, Robert W., additional, McDonald, Colm, additional, Meier, Sandra, additional, Meijer, Carin J., additional, Melegh, Bela, additional, Mesholam-Gately, Raquelle I., additional, Metspalu, Andres, additional, Michie, Patricia T., additional, Milanova, Vihra, additional, Mokrab, Younes, additional, Morris, Derek W., additional, Murphy, Kieran C., additional, Myin-Germeys, Inez, additional, Nelis, Mari, additional, Nenadic, Igor, additional, Nertney, Deborah A., additional, Nestadt, Gerald, additional, Nicodemus, Kristin K., additional, Nikitina-Zake, Liene, additional, Nisenbaum, Laura, additional, Nordin, Annelie, additional, O’Callaghan, Eadbhard, additional, O’Dushlaine, Colm, additional, O’Neill, F. Anthony, additional, Oh, Sang-Yun, additional, Olincy, Ann, additional, Olsen, Line, additional, Van Os, Jim, additional, Pantelis, Christos, additional, Papadimitriou, George N., additional, Papiol, Sergi, additional, Parkhomenko, Elena, additional, Paunio, Tiina, additional, Pejovic-Milovancevic, Milica, additional, Perkins, Diana O., additional, Pietiläinen, Olli, additional, Pimm, Jonathan, additional, Pocklington, Andrew J., additional, Powell, John, additional, Price, Alkes, additional, Pulver, Ann E., additional, Purcell, Shaun M., additional, Quested, Digby, additional, Rasmussen, Henrik B., additional, Reichenberg, Abraham, additional, Reimers, Mark A., additional, Richards, Alexander L., additional, Roffman, Joshua L., additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Salomaa, Veikko, additional, Schall, Ulrich, additional, Schubert, Christian R., additional, Schwab, Sibylle G., additional, Scolnick, Edward M., additional, Scott, Rodney J., additional, Seidman, Larry J., additional, Sigurdsson, Engilbert, additional, Silagadze, Teimuraz, additional, Silverman, Jeremy M., additional, Sim, Kang, additional, Slominsky, Petr, additional, So, Hon-Cheong, additional, Spencer, Chris C.A., additional, Stefansson, Hreinn, additional, Steinberg, Stacy, additional, Stogmann, Elisabeth, additional, Straub, Richard E., additional, Strengman, Eric, additional, Strohmaier, Jana, additional, Stroup, T. Scott, additional, Subramaniam, Mythily, additional, Suvisaari, Jaana, additional, Svrakic, Dragan M., additional, Szatkiewicz, Jin P., additional, Söderman, Erik, additional, Thirumalai, Srinivas, additional, Toncheva, Draga, additional, Tosato, Sarah, additional, Veijola, Juha, additional, Waddington, John, additional, Walsh, Dermot, additional, Wang, Dai, additional, Wang, Qiang, additional, Webb, Bradley T., additional, Weiser, Mark, additional, Wildenauer, Dieter B., additional, Williams, Nigel M., additional, Williams, Stephanie, additional, Witt, Stephanie H., additional, Wolen, Aaron R., additional, Wong, Emily H.M., additional, Wormley, Brandon K., additional, Xi, Hualin Simon, additional, Zai, Clement C., additional, Zheng, Xuebin, additional, Zimprich, Fritz, additional, Wray, Naomi R., additional, Stefansson, Kari, additional, Visscher, Peter M., additional, Blackwood, Douglas H.R., additional, Darvasi, Ariel, additional, Domenici, Enrico, additional, Gill, Michael, additional, Gurling, Hugh, additional, Hultman, Christina M., additional, Jablensky, Assen V., additional, Kendler, Kenneth S., additional, Knight, Jo, additional, Li, Qingqin S., additional, Liu, Jianjun, additional, McCarroll, Steven A., additional, Moran, Jennifer L., additional, Owen, Michael J., additional, Pato, Carlos N., additional, Posthuma, Danielle, additional, Sklar, Pamela, additional, Wendland, Jens R., additional, Daly, Mark J., additional, O’Donovan, Michael C., additional, Donnelly, Peter, additional, Barroso, Ines, additional, Blackwell, Jenefer M., additional, Brown, Matthew A., additional, Casas, Juan P., additional, Deloukas, Panos, additional, Duncanson, Audrey, additional, Jankowski, Janusz, additional, Markus, Hugh S., additional, Mathew, Christopher G., additional, Palmer, Colin N.A., additional, Plomin, Robert, additional, Rautanen, Anna, additional, Sawcer, Stephen J., additional, Trembath, Richard C., additional, Viswanathan, Ananth C., additional, Wood, Nicholas W., additional, Band, Gavin, additional, Bellenguez, Céline, additional, Freeman, Colin, additional, Giannoulatou, Eleni, additional, Hellenthal, Garrett, additional, Pearson, Richard, additional, Pirinen, Matti, additional, Strange, Amy, additional, Su, Zhan, additional, Vukcevic, Damjan, additional, Langford, Cordelia, additional, Blackburn, Hannah, additional, Bumpstead, Suzannah J., additional, Dronov, Serge, additional, Edkins, Sarah, additional, Gillman, Matthew, additional, Gray, Emma, additional, Gwilliam, Rhian, additional, Hammond, Naomi, additional, Hunt, Sarah E., additional, Jayakumar, Alagurevathi, additional, Liddle, Jennifer, additional, McCann, Owen T., additional, Potter, Simon C., additional, Ravindrarajah, Radhi, additional, Ricketts, Michelle, additional, Tashakkori-Ghanbaria, Avazeh, additional, Waller, Matthew, additional, Weston, Paul, additional, Whittaker, Pamela, additional, Widaa, Sara, additional, McCarthy, Mark I., additional, Arranz, Maria J., additional, Bakker, Steven, additional, Bender, Stephan, additional, Crespo-Facorro, Benedicto, additional, Hall, Jeremy, additional, Iyegbe, Conrad, additional, Lawrie, Stephen, additional, Lin, Kuang, additional, Linszen, Don H., additional, Mata, Ignacio, additional, Walshe, Muriel, additional, Weisbrod, Matthias, additional, Wiersma, Durk, additional, Trubetskoy, Vassily, additional, Wang, Yunpeng, additional, Coleman, Jonathan R.I., additional, Gaspar, Héléna A., additional, de Leeuw, Christiaan A., additional, Whitehead Pavlides, Jennifer M., additional, Trzaskowski, Maciej, additional, Byrne, Enda M., additional, Abbott, Liam, additional, Akil, Huda, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Awasthi, Swapnil, additional, Badner, Judith A., additional, Bækvad-Hansen, Marie, additional, Barchas, Jack D., additional, Bass, Nicholas, additional, Bauer, Michael, additional, Belliveau, Richard, additional, Pedersen, Carsten Bøcker, additional, Bøen, Erlend, additional, Boks, Marco P., additional, Boocock, James, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Bybjerg-Grauholm, Jonas, additional, Casas, Miquel, additional, Cerrato, Felecia, additional, Chambert, Kimberly, additional, Charney, Alexander W., additional, Chen, Danfeng, additional, Churchhouse, Claire, additional, Clarke, Toni-Kim, additional, Coryell, William, additional, Craig, David W., additional, Cruceanu, Cristiana, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, de Jong, Simone, additional, Del-Favero, Jurgen, additional, DePaulo, J. Raymond, additional, Dobbyn, Amanda L., additional, Dumont, Ashley, additional, Elvsåshagen, Torbjørn, additional, Fan, Chun Chieh, additional, Fischer, Sascha B., additional, Flickinger, Matthew, additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Fraser, Christine, additional, Gade, Katrin, additional, Gage, Diane, additional, Garnham, Julie, additional, Giambartolomei, Claudia, additional, Pedersen, Marianne Giørtz, additional, Goldstein, Jaqueline, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Guan, Weihua, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Hipolito, Maria, additional, Holland, Dominic, additional, Huckins, Laura, additional, Johnson, Jessica S., additional, Kandaswamy, Radhika, additional, Karlsson, Robert, additional, Kittel-Schneider, Sarah, additional, Koller, Anna C., additional, Kupka, Ralph, additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Lawson, William B., additional, Leber, Markus, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Li, Jun Z., additional, Liu, Chunyu, additional, Maaser, Anna, additional, MacIntyre, Donald J., additional, Mahon, Pamela B., additional, Martinsson, Lina, additional, McCarroll, Steve, additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Meng, Fan, additional, Montgomery, Grant W., additional, Mühleisen, Thomas W., additional, Nguyen, Hoang, additional, Nievergelt, Caroline M., additional, Adolfsson, Annelie Nordin, additional, Nwulia, Evaristus A., additional, O'Donovan, Claire, additional, Olde Loohuis, Loes M., additional, Ori, Anil P.S., additional, Oruc, Lilijana, additional, Ösby, Urban, additional, Perry, Amy, additional, Pfennig, Andrea, additional, Regeer, Eline J., additional, Reinbold, Céline S., additional, Rice, John P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Ryu, Euijung, additional, Sánchez-Mora, Cristina, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schork, Nicholas J., additional, Weickert, Cynthia Shannon, additional, Shehktman, Tatyana, additional, Shilling, Paul D., additional, Slaney, Claire, additional, Sobell, Janet L., additional, Hansen, Christine Søholm, additional, Spijker, Anne T., additional, Steffens, Michael, additional, Strauss, John S., additional, Szelinger, Szabolcs, additional, Thompson, Robert C., additional, Thorgeirsson, Thorgeir E., additional, Treutlein, Jens, additional, Vedder, Helmut, additional, Wang, Weiqing, additional, Watson, Stanley J., additional, Weickert, Thomas W., additional, Xi, Simon, additional, Xu, Wei, additional, Young, Allan H., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zöllner, Sebastian, additional, Abdellaoui, Abdel, additional, Air, Tracy M., additional, Andlauer, Till F.M., additional, Bacanu, Silviu-Alin, additional, Beekman, Aartjan T.F., additional, Binder, Elisabeth B., additional, Bryois, Julien, additional, Buttenschøn, Henriette N., additional, Cai, Na, additional, Castelao, Enrique, additional, Christensen, Jane Hvarregaard, additional, Colodro-Conde, Lucía, additional, Couvy-Duchesne, Baptiste, additional, Crawford, Gregory E., additional, Davies, Gail, additional, Deary, Ian J., additional, Derks, Eske M., additional, Direk, Nese, additional, Dolan, Conor V., additional, Dunn, Erin C., additional, Eley, Thalia C., additional, Hassan Kiadeh, Farnush Farhadi, additional, Finucane, Hilary K., additional, Foo, Jerome C., additional, Goes, Fernando S., additional, Hall, Lynsey S., additional, Hansen, Thomas F., additional, Hickie, Ian B., additional, Homuth, Georg, additional, Horn, Carsten, additional, Howard, David M., additional, Ising, Marcus, additional, Jansen, Rick, additional, Jones, Ian, additional, Jones, Lisa A., additional, Jorgenson, Eric, additional, Kohane, Isaac S., additional, Kraft, Julia, additional, Kretzschmar, Warren W., additional, Kutalik, Zoltán, additional, Li, Yihan, additional, Lind, Penelope A., additional, MacKinnon, Dean F., additional, Maier, Robert M., additional, Marchini, Jonathan, additional, Mbarek, Hamdi, additional, McGrath, Patrick, additional, Middeldorp, Christel M., additional, Mihailov, Evelin, additional, Mondimore, Francis M., additional, Mostafavi, Sara, additional, Nauck, Matthias, additional, Ng, Bernard, additional, Nivard, Michel G., additional, Nyholt, Dale R., additional, O'Reilly, Paul F., additional, Oskarsson, Hogni, additional, Painter, Jodie N., additional, Peterson, Roseann E., additional, Peyrot, Wouter J., additional, Pistis, Giorgio, additional, Quiroz, Jorge A., additional, Qvist, Per, additional, Mirza, Saira Saeed, additional, Schoevers, Robert, additional, Schulte, Eva C., additional, Shen, Ling, additional, Shyn, Stanley I., additional, Sinnamon, Grant C.B., additional, Smit, Johannes H., additional, Smith, Daniel J., additional, Tansey, Katherine E., additional, Teismann, Henning, additional, Thompson, Wesley, additional, Thomson, Pippa A., additional, Traylor, Matthew, additional, Uitterlinden, André G., additional, Umbricht, Daniel, additional, van Hemert, Albert M., additional, Weinsheimer, Shantel Marie, additional, Wellmann, Jürgen, additional, Wu, Yang, additional, Xi, Hualin S., additional, Yang, Jian, additional, Zhang, Futao, additional, Arolt, Volker, additional, Berger, Klaus, additional, Dannlowski, Udo, additional, Domschke, Katharina, additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Kloiber, Stefan, additional, Lewis, Glyn, additional, Madden, Pamela AF., additional, Magnusson, Patrik K., additional, Mortensen, Preben Bo, additional, O'Donovan, Michael C., additional, Paciga, Sara A., additional, Pedersen, Nancy L., additional, Porteous, David J., additional, Schaefer, Catherine, additional, Völzke, Henry, additional, Blokland, Gabriëlla A.M., additional, Bortolato, Marco, additional, Bralten, Janita, additional, Bulik, Cynthia M., additional, Burton, Christie L., additional, Carey, Caitlin E., additional, Davis, Lea K., additional, Duncan, Laramie E., additional, Edenberg, Howard J., additional, Erdman, Lauren, additional, Faraone, Stephen V., additional, Goleva, Slavina B., additional, Guo, Wei, additional, Hübel, Christopher, additional, Huckins, Laura M., additional, Khramtsova, Ekaterina A., additional, Martin, Joanna, additional, Mathews, Carol A., additional, Robinson, Elise, additional, Stahl, Eli, additional, Stranger, Barbara E., additional, Traglia, Michela, additional, Walters, Raymond K., additional, Weiss, Lauren A., additional, Winham, Stacey J., additional, Yao, Yin, additional, Skajaa, Kristjar, additional, Nöthen, Markus, additional, Owen, Michael, additional, Yolken, Robert H., additional, Plath, Niels, additional, Mill, Jonathan, additional, and Geschwind, Daniel, additional

Published
2022
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17. Gender differences in the mental health impact of the COVID-19 lockdown: Longitudinal evidence from the Netherlands

Author

Vloo, A., primary, Alessie, R.J.M., additional, Mierau, J.O., additional, Boezen, Marike H., additional, Mierau, Jochen O., additional, Franke, Lude, additional, Dekens, Jackie, additional, Deelen, Patrick, additional, Lanting, Pauline, additional, Vonk, Judith M., additional, Nolte, Ilja, additional, Ori, Anil P.S., additional, Claringbould, Annique, additional, Boulogne, Floranne, additional, Dijkema, Marjolein X.L., additional, Wiersma, Henry H., additional, Warmerdam, Robert, additional, and Jankipersadsing, Soesma A., additional

Published
2021
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18. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Author

Jia, Tianye, Chu, Congying, Liu, Yun, van Dongen, Jenny, Papastergios, Evangelos, Armstrong, Nicola J., Bastin, Mark E., Carrillo-Roa, Tania, den Braber, Anouk, Harris, Mathew, Jansen, Rick, Liu, Jingyu, Luciano, Michelle, Ori, Anil P.S., Roiz Santiañez, Roberto, Ruggeri, Barbara, Sarkisyan, Daniil, Shin, Jean, Sungeun, Kim, Tordesillas Gutiérrez, Diana, van’t Ent, Dennis, Ames, David, Artiges, Eric, Bakalkin, Georgy, Banaschewski, Tobias, Bokde, Arun L.W., Brodaty, Henry, Bromberg, Uli, Brouwer, Rachel, Büchel, Christian, Burke Quinlan, Erin, Cahn, Wiepke, de Zubicaray, Greig I., Ehrlich, Stefan, Ekström, Tomas J., Flor, Herta, Fröhner, Juliane H., Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Hoare, Jacqueline, Ittermann, Bernd, Jahanshad, Neda, Jiang, Jiyang, Kwok, John B., Martin, Nicholas G., Martinot, Jean Luc, Mather, Karen A., McMahon, Katie L., McRae, Allan F., Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Sämann, Philipp G., Schofield, Peter R., Smolka, Michael N., Stein, Dan J., Strike, Lachlan T., Teeuw, Jalmar, Thalamuthu, Anbupalam, Trollor, Julian, Walter, Henrik, Wardlaw, Joanna M., Wen, Wei, Whelan, Robert, Apostolova, Liana G., Binder, Elisabeth B., Boomsma, Dorret I., Calhoun, Vince, Crespo-Facorro, Benedicto, Deary, Ian J., Hulshoff Pol, Hilleke, Ophoff, Roel A., Pausova, Zdenka, Sachdev, Perminder S., Saykin, Andrew, Wright, Margaret J., Thompson, Paul M., Schumann, Gunter, Desrivières, Sylvane, Jia, Tianye, Chu, Congying, Liu, Yun, van Dongen, Jenny, Papastergios, Evangelos, Armstrong, Nicola J., Bastin, Mark E., Carrillo-Roa, Tania, den Braber, Anouk, Harris, Mathew, Jansen, Rick, Liu, Jingyu, Luciano, Michelle, Ori, Anil P.S., Roiz Santiañez, Roberto, Ruggeri, Barbara, Sarkisyan, Daniil, Shin, Jean, Sungeun, Kim, Tordesillas Gutiérrez, Diana, van’t Ent, Dennis, Ames, David, Artiges, Eric, Bakalkin, Georgy, Banaschewski, Tobias, Bokde, Arun L.W., Brodaty, Henry, Bromberg, Uli, Brouwer, Rachel, Büchel, Christian, Burke Quinlan, Erin, Cahn, Wiepke, de Zubicaray, Greig I., Ehrlich, Stefan, Ekström, Tomas J., Flor, Herta, Fröhner, Juliane H., Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Hoare, Jacqueline, Ittermann, Bernd, Jahanshad, Neda, Jiang, Jiyang, Kwok, John B., Martin, Nicholas G., Martinot, Jean Luc, Mather, Karen A., McMahon, Katie L., McRae, Allan F., Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Sämann, Philipp G., Schofield, Peter R., Smolka, Michael N., Stein, Dan J., Strike, Lachlan T., Teeuw, Jalmar, Thalamuthu, Anbupalam, Trollor, Julian, Walter, Henrik, Wardlaw, Joanna M., Wen, Wei, Whelan, Robert, Apostolova, Liana G., Binder, Elisabeth B., Boomsma, Dorret I., Calhoun, Vince, Crespo-Facorro, Benedicto, Deary, Ian J., Hulshoff Pol, Hilleke, Ophoff, Roel A., Pausova, Zdenka, Sachdev, Perminder S., Saykin, Andrew, Wright, Margaret J., Thompson, Paul M., Schumann, Gunter, and Desrivières, Sylvane

Abstract

DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)—three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.

Published
2021

19. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Author

Andlauer, Till F.M., Guzman-Parra, Jose, Streit, Fabian, Strohmaier, Jana, González, Maria José, Gil Flores, Susana, Cabaleiro Fabeiro, Francisco J., del Río Noriega, Francisco, Perez, Fermin Perez, Haro González, Jesus, Orozco Diaz, Guillermo, de Diego-Otero, Yolanda, Moreno-Küstner, Berta, Auburger, Georg, Degenhardt, Franziska, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffmann, Per, Frank, Josef, Foo, Jerome C., Treutlein, Jens, Witt, Stephanie H., Cichon, Sven, Kogevinas, Manolis, Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M.Whitehead, Trzaskowski, Maciej, Pers, Tune H., Holmans, Peter A., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Czerski, Piotr M., Dale, Anders M., de Jong, Simone, Del-Favero, Jurgen, DePaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grove, Jakob, Guan, Weihua, Parra, José Guzman, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Hipolito, Maria, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Mühleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O’Donovan, Claire, Loohuis, Loes M.Olde, Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Richards, Alexander L., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Weickert, Cynthia Shannon, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B., Sobell, Janet L., Hansen, Christine Søholm, Spijker, Anne T., Clair, David St, Steffens, Michael, Strauss, John S., Szelinger, Szabolcs, Thompson, Robert C., EThorgeirsson, Thorgeir, Vedde, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gill, Michael, Martin, Nicholas G., Schofield, Peter R., Sullivan, Patrick F., Adams, Mark J., Colodro-Conde, Lucía, Derks, Eske M., Howard, David M., Lind, Penelope A., Mehta, Divya, Nyholt, Dale R., Smith, Daniel J., Visscher, Peter M., other, and, Andlauer, Till F.M., Guzman-Parra, Jose, Streit, Fabian, Strohmaier, Jana, González, Maria José, Gil Flores, Susana, Cabaleiro Fabeiro, Francisco J., del Río Noriega, Francisco, Perez, Fermin Perez, Haro González, Jesus, Orozco Diaz, Guillermo, de Diego-Otero, Yolanda, Moreno-Küstner, Berta, Auburger, Georg, Degenhardt, Franziska, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffmann, Per, Frank, Josef, Foo, Jerome C., Treutlein, Jens, Witt, Stephanie H., Cichon, Sven, Kogevinas, Manolis, Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M.Whitehead, Trzaskowski, Maciej, Pers, Tune H., Holmans, Peter A., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Czerski, Piotr M., Dale, Anders M., de Jong, Simone, Del-Favero, Jurgen, DePaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grove, Jakob, Guan, Weihua, Parra, José Guzman, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Hipolito, Maria, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Mühleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O’Donovan, Claire, Loohuis, Loes M.Olde, Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Richards, Alexander L., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Weickert, Cynthia Shannon, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B., Sobell, Janet L., Hansen, Christine Søholm, Spijker, Anne T., Clair, David St, Steffens, Michael, Strauss, John S., Szelinger, Szabolcs, Thompson, Robert C., EThorgeirsson, Thorgeir, Vedde, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gill, Michael, Martin, Nicholas G., Schofield, Peter R., Sullivan, Patrick F., Adams, Mark J., Colodro-Conde, Lucía, Derks, Eske M., Howard, David M., Lind, Penelope A., Mehta, Divya, Nyholt, Dale R., Smith, Daniel J., Visscher, Peter M., and other, and

Abstract

Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development.

Published
2021

20. Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect

Author

Genetica Groep Koeleman, Onderzoeksgroep 2, Brain, Onderzoeksgroep 11, Hersenen-Bedrijfsvoering, Krebs, Catharine E., Ori, Anil P.S., Vreeker, Annabel, Wu, Timothy, Cantor, Rita M., Boks, Marco P.M., Kahn, Rene S., Olde Loohuis, Loes M., Ophoff, Roel A., Genetica Groep Koeleman, Onderzoeksgroep 2, Brain, Onderzoeksgroep 11, Hersenen-Bedrijfsvoering, Krebs, Catharine E., Ori, Anil P.S., Vreeker, Annabel, Wu, Timothy, Cantor, Rita M., Boks, Marco P.M., Kahn, Rene S., Olde Loohuis, Loes M., and Ophoff, Roel A.

Published
2020

21. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

Author

Coleman, Jonathan R.I., primary, Gaspar, Héléna A., additional, Bryois, Julien, additional, Breen, Gerome, additional, Byrne, Enda M., additional, Forstner, Andreas J., additional, Holmans, Peter A., additional, de Leeuw, Christiaan A., additional, Mattheisen, Manuel, additional, McQuillin, Andrew, additional, Whitehead Pavlides, Jennifer M., additional, Pers, Tune H., additional, Ripke, Stephan, additional, Stahl, Eli A., additional, Steinberg, Stacy, additional, Trubetskoy, Vassily, additional, Trzaskowski, Maciej, additional, Wang, Yunpeng, additional, Abbott, Liam, additional, Abdellaoui, Abdel, additional, Adams, Mark J., additional, Adolfsson, Annelie Nordin, additional, Agerbo, Esben, additional, Akil, Huda, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Als, Thomas D., additional, Andlauer, Till F.M., additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Van der Auwera, Sandra, additional, Awasthi, Swapnil, additional, Bacanu, Silviu-Alin, additional, Badner, Judith A., additional, Bækvad-Hansen, Marie, additional, Barchas, Jack D., additional, Bass, Nicholas, additional, Bauer, Michael, additional, Beekman, Aartjan T.F., additional, Belliveau, Richard, additional, Bergen, Sarah E., additional, Bigdeli, Tim B., additional, Binder, Elisabeth B., additional, Bøen, Erlend, additional, Boks, Marco, additional, Boocock, James, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Buttenschøn, Henriette N., additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cai, Na, additional, Casas, Miquel, additional, Castelao, Enrique, additional, Cerrato, Felecia, additional, Cervantes, Pablo, additional, Chambert, Kimberly, additional, Charney, Alexander W., additional, Chen, Danfeng, additional, Christensen, Jane Hvarregaard, additional, Churchhouse, Claire, additional, St Clair, David, additional, Clarke, Toni-Kim, additional, Colodro-Conde, Lucía, additional, Coryell, William, additional, Couvy-Duchesne, Baptiste, additional, Craig, David W., additional, Crawford, Gregory E., additional, Cruceanu, Cristiana, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Davies, Gail, additional, Deary, Ian J., additional, Degenhardt, Franziska, additional, Del-Favero, Jurgen, additional, DePaulo, J Raymond, additional, Derks, Eske M., additional, Direk, Nese, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Dolan, Conor V., additional, Dumont, Ashley, additional, Dunn, Erin C., additional, Eley, Thalia C., additional, Elvsåshagen, Torbjørn, additional, Escott-Price, Valentina, additional, Fan, Chun Chieh, additional, Finucane, Hilary K., additional, Fischer, Sascha B., additional, Flickinger, Matthew, additional, Foo, Jerome C., additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Fraser, Christine, additional, Freimer, Nelson B., additional, Frisén, Louise, additional, Gade, Katrin, additional, Gage, Diane, additional, Garnham, Julie, additional, Giambartolomei, Claudia, additional, Goes, Fernando S., additional, Goldstein, Jaqueline, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Grove, Jakob, additional, Guan, Weihua, additional, Hall, Lynsey S., additional, Hamshere, Marian L., additional, Hansen, Christine Søholm, additional, Hansen, Thomas F., additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, van Hemert, Albert M., additional, Herms, Stefan, additional, Hickie, Ian B., additional, Hipolito, Maria, additional, Hoffmann, Per, additional, Holland, Dominic, additional, Homuth, Georg, additional, Horn, Carsten, additional, Hottenga, Jouke-Jan, additional, Huckins, Laura, additional, Ising, Marcus, additional, Jamain, Stéphane, additional, Jansen, Rick, additional, Johnson, Jessica S., additional, de Jong, Simone, additional, Jorgenson, Eric, additional, Juréus, Anders, additional, Kandaswamy, Radhika, additional, Karlsson, Robert, additional, Kennedy, James L., additional, Hassan Kiadeh, Farnush Farhadi, additional, Kittel-Schneider, Sarah, additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Kohane, Isaac S., additional, Koller, Anna C., additional, Kraft, Julia, additional, Kretzschmar, Warren W., additional, Krogh, Jesper, additional, Kupka, Ralph, additional, Kutalik, Zoltán, additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Lawson, William B., additional, Leber, Markus, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Li, Jun Z., additional, Li, Yihan, additional, Lind, Penelope A., additional, Liu, Chunyu, additional, Olde Loohuis, Loes M., additional, Maaser, Anna, additional, MacIntyre, Donald J., additional, MacKinnon, Dean F., additional, Mahon, Pamela B., additional, Maier, Wolfgang, additional, Maier, Robert M., additional, Marchini, Jonathan, additional, Martinsson, Lina, additional, Mbarek, Hamdi, additional, McCarroll, Steve, additional, McGrath, Patrick, additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Mehta, Divya, additional, Meng, Fan, additional, Middeldorp, Christel M., additional, Mihailov, Evelin, additional, Milaneschi, Yuri, additional, Milani, Lili, additional, Mirza, Saira Saeed, additional, Mondimore, Francis M., additional, Montgomery, Grant W., additional, Morris, Derek W., additional, Mostafavi, Sara, additional, Mühleisen, Thomas W., additional, Mullins, Niamh, additional, Nauck, Matthias, additional, Ng, Bernard, additional, Nguyen, Hoang, additional, Nievergelt, Caroline M., additional, Nivard, Michel G., additional, Nwulia, Evaristus A., additional, Nyholt, Dale R., additional, O'Donovan, Claire, additional, O'Reilly, Paul F., additional, Ori, Anil P.S., additional, Oruc, Lilijana, additional, Ösby, Urban, additional, Oskarsson, Hogni, additional, Painter, Jodie N., additional, Parra, José Guzman, additional, Pedersen, Carsten Bøcker, additional, Pedersen, Marianne Giørtz, additional, Perry, Amy, additional, Peterson, Roseann E., additional, Pettersson, Erik, additional, Peyrot, Wouter J., additional, Pfennig, Andrea, additional, Pistis, Giorgio, additional, Purcell, Shaun M., additional, Quiroz, Jorge A., additional, Qvist, Per, additional, Regeer, Eline J., additional, Reif, Andreas, additional, Reinbold, Céline S., additional, Rice, John P., additional, Riley, Brien P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Ryu, Euijung, additional, Sánchez-Mora, Cristina, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schoevers, Robert, additional, Schork, Nicholas J., additional, Schulte, Eva C., additional, Shehktman, Tatyana, additional, Shen, Ling, additional, Shi, Jianxin, additional, Shilling, Paul D., additional, Shyn, Stanley I., additional, Sigurdsson, Engilbert, additional, Slaney, Claire, additional, Smeland, Olav B., additional, Smit, Johannes H., additional, Smith, Daniel J., additional, Sobell, Janet L., additional, Spijker, Anne T., additional, Steffens, Michael, additional, Strauss, John S., additional, Streit, Fabian, additional, Strohmaier, Jana, additional, Szelinger, Szabolcs, additional, Tansey, Katherine E., additional, Teismann, Henning, additional, Teumer, Alexander, additional, Thompson, Robert C., additional, Thompson, Wesley, additional, Thomson, Pippa A., additional, Thorgeirsson, Thorgeir E., additional, Traylor, Matthew, additional, Treutlein, Jens, additional, Uitterlinden, André G., additional, Umbricht, Daniel, additional, Vedder, Helmut, additional, Viktorin, Alexander, additional, Visscher, Peter M., additional, Wang, Weiqing, additional, Watson, Stanley J., additional, Webb, Bradley T., additional, Weickert, Cynthia Shannon, additional, Weickert, Thomas W., additional, Weinsheimer, Shantel Marie, additional, Wellmann, Jürgen, additional, Willemsen, Gonneke, additional, Witt, Stephanie H., additional, Wu, Yang, additional, Xi, Hualin S., additional, Xu, Wei, additional, Yang, Jian, additional, Young, Allan H., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zhang, Futao, additional, Zollner, Sebastian, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Alda, Martin, additional, Arolt, Volker, additional, Backlund, Lena, additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Berger, Klaus, additional, Berrettini, Wade H., additional, Biernacka, Joanna M., additional, Blackwood, Douglas H.R., additional, Boehnke, Michael, additional, Boomsma, Dorret I., additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Daly, Mark J., additional, Dannlowski, Udo, additional, Domenici, Enrico, additional, Domschke, Katharina, additional, Esko, Tõnu, additional, Etain, Bruno, additional, Frye, Mark, additional, Fullerton, Janice M., additional, Gershon, Elliot S., additional, de Geus, E.J.C., additional, Gill, Michael, additional, Goes, Fernando, additional, Grabe, Hans J., additional, Grigoroiu-Serbanescu, Maria, additional, Hamilton, Steven P., additional, Hauser, Joanna, additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Hougaard, David M., additional, Hultman, Christina M., additional, Jones, Ian, additional, Jones, Lisa A., additional, Kahn, René S., additional, Kendler, Kenneth S., additional, Kirov, George, additional, Kloiber, Stefan, additional, Landén, Mikael, additional, Leboyer, Marion, additional, Lewis, Glyn, additional, Li, Qingqin S., additional, Lissowska, Jolanta, additional, Lucae, Susanne, additional, Madden, Pamela A.F., additional, Magnusson, Patrik K., additional, Martin, Nicholas G., additional, Mayoral, Fermin, additional, McElroy, Susan L., additional, McIntosh, Andrew M., additional, McMahon, Francis J., additional, Melle, Ingrid, additional, Metspalu, Andres, additional, Mitchell, Philip B., additional, Morken, Gunnar, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Müller-Myhsok, Bertram, additional, Myers, Richard M., additional, Neale, Benjamin M., additional, Nimgaonkar, Vishwajit, additional, Nordentoft, Merete, additional, Nöthen, Markus M., additional, O'Donovan, Michael C., additional, Oedegaard, Ketil J., additional, Owen, Michael J., additional, Paciga, Sara A., additional, Pato, Carlos, additional, Pato, Michele T., additional, Pedersen, Nancy L., additional, Penninx, Brenda W.J. H., additional, Perlis, Roy H., additional, Porteous, David J., additional, Posthuma, Danielle, additional, Potash, James B., additional, Preisig, Martin, additional, Ramos-Quiroga, Josep Antoni, additional, Ribasés, Marta, additional, Rietschel, Marcella, additional, Rouleau, Guy A., additional, Schaefer, Catherine, additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schulze, Thomas G., additional, Serretti, Alessandro, additional, Smoller, Jordan W., additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Stordal, Eystein, additional, Tiemeier, Henning, additional, Turecki, Gustavo, additional, Uher, Rudolf, additional, Vaaler, Arne E., additional, Vieta, Eduard, additional, Vincent, John B., additional, Völzke, Henry, additional, Weissman, Myrna M., additional, Werge, Thomas, additional, Andreassen, Ole A., additional, Børglum, Anders D., additional, Cichon, Sven, additional, Edenberg, Howard J., additional, Di Florio, Arianna, additional, Kelsoe, John, additional, Levinson, Douglas F., additional, Lewis, Cathryn M., additional, Nurnberger, John I., additional, Ophoff, Roel A., additional, Scott, Laura J., additional, Sklar, Pamela, additional, Sullivan, Patrick F., additional, and Wray, Naomi R., additional

Published
2020
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22. The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

Author

Intyre, Kate Mc, primary, Lanting, Pauline, additional, Deelen, Patrick, additional, Wiersma, Henry, additional, Vonk, Judith M., additional, Ori, Anil P.S., additional, Jankipersadsing, Soesma A., additional, Warmerdam, Robert, additional, van Blokland, Irene, additional, Boulogne, Floranne, additional, Dijkema, Marjolein X.L., additional, Herkert, Johanna C., additional, Claringbould, Annique, additional, Bakker, Olivier, additional, Lopera Maya, Esteban A., additional, Bültmann, Ute, additional, Zhernakova, Alexandra, additional, Reijneveld, Sijmen A., additional, Zijlstra, Elianne, additional, Swertz, Morris, additional, Brouwer, Sandra, additional, van Ooijen, R., additional, Angelini, Viola, additional, Dekker, Louise, additional, Sijtsma, Anna, additional, Scherjon, Sicco A., additional, Dekens, Jackie, additional, Mierau, Jochen O., additional, Boezen, H. Marike, additional, and Franke, Lude, additional

Published
2020
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23. Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging

Author

Ori, Anil P.S., Olde Loohuis, Loes M., Guintivano, Jerry, Hannon, Eilis, Dempster, Emma, St. Clair, David, Bass, Nick J, McQuillin, Andrew, Mill, Jonathan, Sullivan, Patrick F, Kahn, Rene S., Horvath, Steve, and Ophoff, Roel A.

Abstract

Schizophrenia (SCZ) is a severe mental illness that is associated with an increased prevalence of age-related disability and morbidity compared to the general population. An accelerated aging process has therefore been hypothesized as a component of the SCZ disease trajectory. Here, we investigated differential aging using three DNA methylation (DNAm) clocks (i.e. Hannum, Horvath, Levine) in a multi-cohort SCZ whole blood sample consisting of 1,100 SCZ cases and 1,200 controls. It is known that all three DNAm clocks are highly predictive of chronological age and capture different features of biological aging. We found that blood-based DNAm aging is significantly altered in SCZ with age- and sexspecific effects that differ between clocks and map to distinct chronological age windows. Most notably, the predicted phenotypic age (Levine clock) in female cases, starting at age 36 and beyond, is 3.21 years older compared to matching control subjects (95% CI: 1.92-4.50, P=1.3e-06) explaining 7.7% of the variance in disease status. Female cases with high SCZ polygenic risk scores present the highest age acceleration in this age group with +7.03 years (95% CI: 3.87-10.18, P=1.7E-05). Since increased phenotypic age is associated with increased risk of all-cause mortality, our findings suggests that specific and identifiable patient groups are at increased mortality risk as measured by the Levine clock. These results provide new biological insights into the aging landscape of SCZ with age- and sexspecific effects and warrant further investigations into the potential of DNAm clocks as clinical biomarkers that may help with disease management in schizophrenia.

Published
2019
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24. Genome-wide association study identifies 30 loci associated with bipolar disorder

Author

Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Byrne, Enda M., Pers, Tune H., Holmans, Peter A., Richards, Alexander L., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco P., Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alxander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M., Dale, Anders, de Jong, Simone, Degenhardt, Franziska, Del-Favero, Jurgen, Depaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tifany A., Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Mühleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O'Donovan, Claire, Loohuis, Loes M. Olde, Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Shannon Weickert, Cynthia, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav Bjerkehagen, Sobell, Janet L., Søholm Hansen, Christine, Spijker, Anne T., St Clair, David, Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C., Thorgeirsson, Thorgeir E, Treutlein, Jens, Vedder, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Witt, Stephanie H., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zöllner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., Gill, Michael, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hougaard, David M., Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, René S., Kirov, George, Landén, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C, Ødegaard, Ketil Joachim, Owen, Michael J., Paciga, Sara A., Pato, Carlos, Pato, Michele T., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A., Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne, Vieta, Eduard, Vincent, John B., Werge, Thomas, Nurnberger, John I., Wray, Naomi R., Di Florio, Arianna, Edenberg, Howard J., Cichon, Sven, Ophoff, Roel A., Scott, Laura J., Andreassen, Ole Andreas, Kelsoe, John, and Sklar, Pamela

Abstract

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P

Published
2019

25. Sex and Gender-Related Differences in COVID-19 Diagnoses and SARS-CoV-2 Testing Practices During the First Wave of the Pandemic: The Dutch Lifelines COVID-19 Cohort Study.

Author

Ballering, Aranka Viviënne, Oertelt-Prigione, Sabine, olde Hartman, Tim C., Rosmalen, Judith G.M., Boezen, Marike, Mierau, Jochen O., Franke, Lude H., Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X.L., Wiersma, Henry H., Warmerdam, Robert, and Jankipersadsing, Soesma A.

Subjects
STATISTICS, EVALUATION of medical care, REVERSE transcriptase polymerase chain reaction, COVID-19, CONFIDENCE intervals, MULTIPLE regression analysis, SEX distribution, EMPLOYMENT, DESCRIPTIVE statistics, COVID-19 testing, POLYMERASE chain reaction, SMOKING, ODDS ratio, COVID-19 pandemic, LONGITUDINAL method, COMORBIDITY
Abstract

Background: Although sex differences are described in Coronavirus Disease 2019 (COVID-19) diagnoses and testing, many studies neglect possible gender-related influences. Additionally, research is often performed in clinical populations, while most COVID-19 patients are not hospitalized. Therefore, we investigated associations between sex and gender-related variables, and COVID-19 diagnoses and testing practices in a large general population cohort during the first wave of the pandemic when testing capacity was limited. Methods: We used data from the Lifelines COVID-19 Cohort (N = 74,722; 60.8% female). We applied bivariate and multiple logistic regression analyses. The outcomes were a COVID-19 diagnosis (confirmed by SARS-CoV-2 PCR testing or physician's clinical diagnosis) and PCR testing. Independent variables included among others participants' sex, age, somatic comorbidities, occupation, and smoking status. Sex-by-comorbidity and sex-by-occupation interaction terms were included to investigate sex differences in associations between the presence of comorbidities or an occupation with COVID-19 diagnoses or testing practices. Results: In bivariate analyses female sex was significantly associated with COVID-19 diagnoses and testing, but significance did not persist in multiple logistic regression analyses. However, a gender-related variable, being a health care worker, was significantly associated with COVID-19 diagnoses (OR = 1.68; 95%CI = 1.30–2.17) and testing (OR = 12.5; 95%CI = 8.55–18.3). Female health care workers were less often diagnosed and tested than male health care workers (ORinteraction = 0.54; 95%CI = 0.32–0.92, ORinteraction = 0.53; 95%CI = 0.29–0.97, respectively). Conclusions: We found no sex differences in COVID-19 diagnoses and testing in the general population. Among health care workers, a male preponderance in COVID-19 diagnoses and testing was observed. This could be explained by more pronounced COVID-19 symptoms in males or by gender inequities. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Author

Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Boocock, James, Stahl, Eli A., Pavlides, Jennifer M.Whitehead, Mullins, Niamh, Charney, Alexander W., Ori, Anil P.S., Loohuis, Loes M.Olde, Domenici, Enrico, Di Florio, Arianna, Papiol, Sergi, Kalman, Janos L., Trubetskoy, Vassily, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Akil, Huda, Albani, Diego, Albus, Margot, Alda, Martin, Alexander, Madeline, Alliey-Rodriguez, Ney, Als, Thomas D., Amin, Farooq, Anjorin, Adebayo, Arranz, Maria J., Awasthi, Swapnil, Bacanu, Silviu A., Badner, Judith A., Baekvad-Hansen, Marie, Bakker, Steven, Band, Gavin, Barchas, Jack D., Barroso, Ines, Bass, Nicholas, Bauer, Michael, Baune, Bernhard T., Begemann, Martin, Bellenguez, Celine, Belliveau, Richard A., Bellivier, Frank, Bender, Stephan, Boks, Marco, Cahn, Wiepke, Kahn, Rene S., Van Os, Jim, Strengman, Eric, Ophoff, Roel A., Psychosis Endophenotypes International Consortium, Wellcome Trust Case-Control Consortium, and Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu

Subjects
bipolar disorder, schizophrenia, polygenic risk, Biochemistry, Genetics and Molecular Biology(all), psychosis, subphenotypes
Abstract

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several significant correlations within case-only phenotypes including SCZ PRS with psychotic features and age of onset in BD. For the first time, we discover specific loci that distinguish between BD and SCZ and identify polygenic components underlying multiple symptom dimensions. These results point to the utility of genetics to inform symptomology and potential treatment. Genetic analysis of multiple bipolar disorder and schizophrenia cohorts reveals loci and polygenic risk scores that differentiate the clinical symptoms of these two highly correlated disorders.

Published
2018

27. Epigenome-wide association study of leukocyte telomere length

Author

Lee, Yunsung, primary, Sun, Dianjianyi, additional, Ori, Anil P.S., additional, Lu, Ake T., additional, Seeboth, Anne, additional, Harris, Sarah E., additional, Deary, Ian J., additional, Marioni, Riccardo E., additional, Soerensen, Mette, additional, Mengel-From, Jonas, additional, Hjelmborg, Jacob, additional, Christensen, Kaare, additional, Wilson, James G., additional, Levy, Daniel, additional, Reiner, Alex P., additional, Chen, Wei, additional, Li, Shengxu, additional, Harris, Jennifer R., additional, Magnus, Per, additional, Aviv, Abraham, additional, Jugessur, Astanand, additional, and Horvath, Steve, additional

Published
2019
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28. Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk

Author

Ori, Anil P.S., primary, Olde Loohuis, Loes M., additional, Guintivano, Jerry, additional, Hannon, Eilis, additional, Dempster, Emma, additional, St. Clair, David, additional, Bass, Nick J, additional, McQuillin, Andrew, additional, Mill, Jonathan, additional, Sullivan, Patrick F, additional, Kahn, Rene S., additional, Horvath, Steve, additional, and Ophoff, Roel A., additional

Published
2019
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29. Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia

Author

Olde Loohuis, Loes M., Mangul, Serghei, Ori, Anil P.S., Jospin, Guillaume, Koslicki, David, Yang, Harry Taegyun, Wu, Timothy, Boks, Marco P., Lomen-Hoerth, Catherine, Wiedau-Pazos, Martina, Cantor, Rita M., De Vos, Willem M., Kahn, René S., Eskin, Eleazar, Ophoff, Roel A., Olde Loohuis, Loes M., Mangul, Serghei, Ori, Anil P.S., Jospin, Guillaume, Koslicki, David, Yang, Harry Taegyun, Wu, Timothy, Boks, Marco P., Lomen-Hoerth, Catherine, Wiedau-Pazos, Martina, Cantor, Rita M., De Vos, Willem M., Kahn, René S., Eskin, Eleazar, and Ophoff, Roel A.

Published
2018

30. Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia

Author

Onderzoeksgroep 2, Brain, Onderzoeksgroep 11, Circulatory Health, Olde Loohuis, Loes M., Mangul, Serghei, Ori, Anil P.S., Jospin, Guillaume, Koslicki, David, Yang, Harry Taegyun, Wu, Timothy, Boks, Marco P., Lomen-Hoerth, Catherine, Wiedau-Pazos, Martina, Cantor, Rita M., De Vos, Willem M., Kahn, René S., Eskin, Eleazar, Ophoff, Roel A., Onderzoeksgroep 2, Brain, Onderzoeksgroep 11, Circulatory Health, Olde Loohuis, Loes M., Mangul, Serghei, Ori, Anil P.S., Jospin, Guillaume, Koslicki, David, Yang, Harry Taegyun, Wu, Timothy, Boks, Marco P., Lomen-Hoerth, Catherine, Wiedau-Pazos, Martina, Cantor, Rita M., De Vos, Willem M., Kahn, René S., Eskin, Eleazar, and Ophoff, Roel A.

Published
2018

31. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Author

Affectieve & Psychotische Med., Onderzoeksgroep 2, Brain, Onderzoek, Onderzoeksgroep 11, Hersenen-Medisch 1, Pathologie, Circulatory Health, Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Boocock, James, Stahl, Eli A., Pavlides, Jennifer M.Whitehead, Mullins, Niamh, Charney, Alexander W., Ori, Anil P.S., Loohuis, Loes M.Olde, Domenici, Enrico, Di Florio, Arianna, Papiol, Sergi, Kalman, Janos L., Trubetskoy, Vassily, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Akil, Huda, Albani, Diego, Albus, Margot, Alda, Martin, Alexander, Madeline, Alliey-Rodriguez, Ney, Als, Thomas D., Amin, Farooq, Anjorin, Adebayo, Arranz, Maria J., Awasthi, Swapnil, Bacanu, Silviu A., Badner, Judith A., Baekvad-Hansen, Marie, Bakker, Steven, Band, Gavin, Barchas, Jack D., Barroso, Ines, Bass, Nicholas, Bauer, Michael, Baune, Bernhard T., Begemann, Martin, Bellenguez, Celine, Belliveau, Richard A., Bellivier, Frank, Bender, Stephan, Boks, Marco, Cahn, Wiepke, Kahn, Rene S., Van Os, Jim, Strengman, Eric, Ophoff, Roel A., Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium, Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu, Affectieve & Psychotische Med., Onderzoeksgroep 2, Brain, Onderzoek, Onderzoeksgroep 11, Hersenen-Medisch 1, Pathologie, Circulatory Health, Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Boocock, James, Stahl, Eli A., Pavlides, Jennifer M.Whitehead, Mullins, Niamh, Charney, Alexander W., Ori, Anil P.S., Loohuis, Loes M.Olde, Domenici, Enrico, Di Florio, Arianna, Papiol, Sergi, Kalman, Janos L., Trubetskoy, Vassily, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Akil, Huda, Albani, Diego, Albus, Margot, Alda, Martin, Alexander, Madeline, Alliey-Rodriguez, Ney, Als, Thomas D., Amin, Farooq, Anjorin, Adebayo, Arranz, Maria J., Awasthi, Swapnil, Bacanu, Silviu A., Badner, Judith A., Baekvad-Hansen, Marie, Bakker, Steven, Band, Gavin, Barchas, Jack D., Barroso, Ines, Bass, Nicholas, Bauer, Michael, Baune, Bernhard T., Begemann, Martin, Bellenguez, Celine, Belliveau, Richard A., Bellivier, Frank, Bender, Stephan, Boks, Marco, Cahn, Wiepke, Kahn, Rene S., Van Os, Jim, Strengman, Eric, Ophoff, Roel A., Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium, and Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu

Published
2018

32. Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect.

Author

Krebs, Catharine E., Ori, Anil P.S., Vreeker, Annabel, Wu, Timothy, Cantor, Rita M., Boks, Marco P. M., Kahn, Rene S., Olde Loohuis, Loes M., and Ophoff, Roel A.

Subjects
*THERAPEUTIC use of lithium, *GENETICS of bipolar disorder, *CELLULAR signal transduction, *IMMUNOTHERAPY, *INFORMATION storage & retrieval systems, *MEDICAL databases, *NEUTROPHILS, *MEDICAL radiology, *DATA analysis, *GENE expression profiling, *DESCRIPTIVE statistics, *IMMUNE checkpoint inhibitors
Abstract

Background: Bipolar disorder (BD) is a highly heritable mood disorder with complex genetic architecture and poorly understood etiology. Previous transcriptomic BD studies have had inconsistent findings due to issues such as small sample sizes and difficulty in adequately accounting for confounders like medication use. Methods: We performed a differential expression analysis in a well-characterized BD case-control sample (Nsubjects = 480) by RNA sequencing of whole blood. We further performed co-expression network analysis, functional enrichment, and cell type decomposition, and integrated differentially expressed genes with genetic risk. Results: While we observed widespread differential gene expression patterns between affected and unaffected individuals, these effects were largely linked to lithium treatment at the time of blood draw (FDR < 0.05, Ngenes = 976) rather than BD diagnosis itself (FDR < 0.05, Ngenes = 6). These lithium-associated genes were enriched for cell signaling and immune response functional annotations, among others, and were associated with neutrophil cell-type proportions, which were elevated in lithium users. Neither genes with altered expression in cases nor in lithium users were enriched for BD, schizophrenia, and depression genetic risk based on information from genome-wide association studies, nor was gene expression associated with polygenic risk scores for BD. Conclusions: These findings suggest that BD is associated with minimal changes in whole blood gene expression independent of medication use but emphasize the importance of accounting for medication use and cell type heterogeneity in psychiatric transcriptomic studies. The results of this study add to mounting evidence of lithium's cell signaling and immune-related mechanisms. [ABSTRACT FROM AUTHOR]

Published
2020
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34. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Author

Jia, Tianye, primary, Chu, Congying, additional, Liu, Yun, additional, Dongen, Jenny van, additional, Armstrong, Nicola J, additional, Bastin, Mark E., additional, Carrillo-Roa, Tania, additional, Braber, Anouk den, additional, Harris, Mathew, additional, Jansen, Rick, additional, Liu, Jingyu, additional, Luciano, Michelle, additional, Ori, Anil P.S., additional, Santiañez, Roberto Roiz, additional, Ruggeri, Barbara, additional, Sarkisyan, Daniil, additional, Shin, Jean, additional, Sungeun, Kim, additional, Gutiérrez, Diana Tordesillas, additional, Ent, Dennis van’t, additional, Ames, David, additional, Artiges, Eric, additional, Bakalkin, Georgy, additional, Banaschewski, Tobias, additional, Bokde, Arun L.W., additional, Brodaty, Henry, additional, Bromberg, Uli, additional, Brouwer, Rachel, additional, Büchel, Christian, additional, Quinlan, Erin Burke, additional, Cahn, Wiepke, additional, de Zubicaray, Greig I., additional, Ekström, Tomas J., additional, Flor, Herta, additional, Fröhner, Juliane H., additional, Frouin, Vincent, additional, Garavan, Hugh, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Jahanshad, Neda, additional, Jiang, Jiyang, additional, Kwok, John B., additional, Martin, Nicholas G., additional, Martinot, Jean-Luc, additional, Mather, Karen A., additional, McMahon, Katie L., additional, McRae, Allan F., additional, Nees, Frauke, additional, Orfanos, Dimitri Papadopoulos, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Sämann, Philipp G., additional, Schofield, Peter R., additional, Smolka, Michael N., additional, Strike, Lachlan T., additional, Teeuw, Jalmar, additional, Thalamuthu, Anbupalam, additional, Trollor, Julian, additional, Walter, Henrik, additional, Wardlaw, Joanna M., additional, Wen, Wei, additional, Whelan, Robert, additional, Apostolova, Liana G., additional, Binder, Elisabeth B., additional, Boomsma, Dorret I., additional, Calhoun, Vince, additional, Crespo-Facorro, Benedicto, additional, Deary, Ian J., additional, Pol, Hilleke Hulshoff, additional, Ophoff, Roel A., additional, Pausova, Zdenka, additional, Sachdev, Perminder S., additional, Saykin, Andrew, additional, Wright, Margaret J., additional, Thompson, Paul M., additional, Schumann, Gunter, additional, and Desrivières, Sylvane, additional

Published
2018
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35. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Author

Ruderfer, Douglas M., primary, Ripke, Stephan, additional, McQuillin, Andrew, additional, Boocock, James, additional, Stahl, Eli A., additional, Pavlides, Jennifer M. Whitehead, additional, Mullins, Niamh, additional, Charney, Alexander W., additional, Ori, Anil P.S., additional, Loohuis, Loes M. Olde, additional, Domenici, Enrico, additional, Di Florio, Arianna, additional, Papiol, Sergi, additional, Kalman, Janos L., additional, Trubetskoy, Vassily, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Agerbo, Esben, additional, Akil, Huda, additional, Albani, Diego, additional, Albus, Margot, additional, Alda, Martin, additional, Alexander, Madeline, additional, Alliey-Rodriguez, Ney, additional, Als, Thomas D., additional, Amin, Farooq, additional, Anjorin, Adebayo, additional, Arranz, Maria J., additional, Awasthi, Swapnil, additional, Bacanu, Silviu A., additional, Badner, Judith A., additional, Baekvad-Hansen, Marie, additional, Bakker, Steven, additional, Band, Gavin, additional, Barchas, Jack D., additional, Barroso, Ines, additional, Bass, Nicholas, additional, Bauer, Michael, additional, Baune, Bernhard T., additional, Begemann, Martin, additional, Bellenguez, Celine, additional, Belliveau, Richard A., additional, Bellivier, Frank, additional, Bender, Stephan, additional, Bene, Judit, additional, Bergen, Sarah E., additional, Berrettini, Wade H., additional, Bevilacqua, Elizabeth, additional, Biernacka, Joanna M., additional, Bigdeli, Tim B., additional, Black, Donald W., additional, Blackburn, Hannah, additional, Blackwell, Jenefer M., additional, Blackwood, Douglas H.R., additional, Pedersen, Carsten Bocker, additional, Boehnke, Michael, additional, Boks, Marco, additional, Borglum, Anders D., additional, Bramon, Elvira, additional, Breen, Gerome, additional, Brown, Matthew A., additional, Bruggeman, Richard, additional, Buccola, Nancy G., additional, Buckner, Randy L., additional, Budde, Monika, additional, Bulik-Sullivan, Brendan, additional, Bumpstead, Suzannah J., additional, Bunney, William, additional, Burmeister, Margit, additional, Buxbaum, Joseph D., additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cahn, Wiepke, additional, Cai, Guiqing, additional, Cairns, Murray J., additional, Campion, Dominique, additional, Cantor, Rita M., additional, Carr, Vaughan J., additional, Carrera, Noa, additional, Casas, Juan P., additional, Casas, Miquel, additional, Catts, Stanley V., additional, Cervantes, Pablo, additional, Chambert, Kimberley D., additional, Chan, Raymond C.K., additional, Chen, Eric Y.H., additional, Chen, Ronald Y.L., additional, Cheng, Wei, additional, Cheung, Eric F.C., additional, Chong, Siow Ann, additional, Clarke, Toni-Kim, additional, Cloninger, C. Robert, additional, Cohen, David, additional, Cohen, Nadine, additional, Coleman, Jonathan R.I., additional, Collier, David A., additional, Cormican, Paul, additional, Coryell, William, additional, Craddock, Nicholas, additional, Craig, David W., additional, Crespo-Facorro, Benedicto, additional, Crowley, James J., additional, Cruceanu, Cristiana, additional, Curtis, David, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Daly, Mark J., additional, Dannlowski, Udo, additional, Darvasi, Ariel, additional, Davidson, Michael, additional, Davis, Kenneth L., additional, de Leeuw, Christiaan A., additional, Degenhardt, Franziska, additional, Del Favero, Jurgen, additional, DeLisi, Lynn E., additional, Deloukas, Panos, additional, Demontis, Ditte, additional, DePaulo, J. Raymond, additional, di Forti, Marta, additional, Dikeos, Dimitris, additional, Dinan, Timothy, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Donnelly, Peter, additional, Donohoe, Gary, additional, Drapeau, Elodie, additional, Dronov, Serge, additional, Duan, Jubao, additional, Dudbridge, Frank, additional, Duncanson, Audrey, additional, Edenberg, Howard, additional, Edkins, Sarah, additional, Ehrenreich, Hannelore, additional, Eichhammer, Peter, additional, Elvsashagen, Torbjorn, additional, Eriksson, Johan, additional, Escott-Price, Valentina, additional, Esko, Tonu, additional, Essioux, Laurent, additional, Etain, Bruno, additional, Fan, Chun Chieh, additional, Farh, Kai-How, additional, Farrell, Martilias S., additional, Flickinger, Matthew, additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Franke, Lude, additional, Fraser, Christine, additional, Freedman, Robert, additional, Freeman, Colin, additional, Freimer, Nelson B., additional, Friedman, Joseph I., additional, Fromer, Menachem, additional, Frye, Mark A., additional, Fullerton, Janice M., additional, Gade, Katrin, additional, Garnham, Julie, additional, Gaspar, Helena A., additional, Gejman, Pablo V., additional, Genovese, Giulio, additional, Georgieva, Lyudmila, additional, Giambartolomei, Claudia, additional, Giannoulatou, Eleni, additional, Giegling, Ina, additional, Gill, Michael, additional, Gillman, Matthew, additional, Pedersen, Marianne Giortz, additional, Giusti-Rodriguez, Paola, additional, Godard, Stephanie, additional, Goes, Fernando, additional, Goldstein, Jacqueline I., additional, Gopal, Srihari, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Gratten, Jacob, additional, Gray, Emma, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Grigoroiu-Serbanescu, Maria, additional, Grove, Jakob, additional, Guan, Weihua, additional, Gurling, Hugh, additional, Parra, Jose Guzman, additional, Gwilliam, Rhian, additional, de Haan, Lieuwe, additional, Hall, Jeremy, additional, Hall, Mei-Hua, additional, Hammer, Christian, additional, Hammond, Naomi, additional, Hamshere, Marian L., additional, Hansen, Mark, additional, Hansen, Thomas, additional, Haroutunian, Vahram, additional, Hartmann, Annette M., additional, Hauser, Joanna, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Hellenthal, Garrett, additional, Henskens, Frans A., additional, Herms, Stefan, additional, Hipolito, Maria, additional, Hirschhorn, Joel N., additional, Hoffmann, Per, additional, Hollegaard, Mads V., additional, Hougaard, David M., additional, Huang, Hailiang, additional, Huckins, Laura, additional, Hultman, Christina M., additional, Hunt, Sarah E., additional, Ikeda, Masashi, additional, Iwata, Nakao, additional, Iyegbe, Conrad, additional, Jablensky, Assen V., additional, Jamain, Stephane, additional, Jankowski, Janusz, additional, Jayakumar, Alagurevathi, additional, Joa, Inge, additional, Jones, Ian, additional, Jones, Lisa A., additional, Jonsson, Erik G., additional, Julia, Antonio, additional, Jureus, Anders, additional, Kahler, Anna K., additional, Kahn, Rene S., additional, Kalaydjieva, Luba, additional, Kandaswamy, Radhika, additional, Karachanak-Yankova, Sena, additional, Karjalainen, Juha, additional, Karlsson, Robert, additional, Kavanagh, David, additional, Keller, Matthew C., additional, Kelly, Brian J., additional, Kelsoe, John, additional, Kennedy, James L., additional, Khrunin, Andrey, additional, Kim, Yunjung, additional, Kirov, George, additional, Kittel-Schneider, Sarah, additional, Klovins, Janis, additional, Knight, Jo, additional, Knott, Sarah V., additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Konte, Bettina, additional, Kravariti, Eugenia, additional, Kucinskas, Vaidutis, additional, Kucinskiene, Zita Ausrele, additional, Kupka, Ralph, additional, Kuzelova-Ptackova, Hana, additional, Landen, Mikael, additional, Langford, Cordelia, additional, Laurent, Claudine, additional, Lawrence, Jacob, additional, Lawrie, Stephen, additional, Lawson, William B., additional, Leber, Markus, additional, Leboyer, Marion, additional, Lee, Phil H., additional, Keong, Jimmy Lee Chee, additional, Legge, Sophie E., additional, Lencz, Todd, additional, Lerer, Bernard, additional, Levinson, Douglas F., additional, Levy, Shawn E., additional, Lewis, Cathryn M., additional, Li, Jun Z., additional, Li, Miaoxin, additional, Li, Qingqin S., additional, Li, Tao, additional, Liang, Kung-Yee, additional, Liddle, Jennifer, additional, Lieberman, Jeffrey, additional, Limborska, Svetlana, additional, Lin, Kuang, additional, Linszen, Don H., additional, Lissowska, Jolanta, additional, Liu, Chunyu, additional, Liu, Jianjun, additional, Lonnqvist, Jouko, additional, Loughland, Carmel M., additional, Lubinski, Jan, additional, Lucae, Susanne, additional, Macek, Milan, additional, MacIntyre, Donald J., additional, Magnusson, Patrik K.E., additional, Maher, Brion S., additional, Mahon, Pamela B., additional, Maier, Wolfgang, additional, Malhotra, Anil K., additional, Mallet, Jacques, additional, Malt, Ulrik F., additional, Markus, Hugh S., additional, Marsal, Sara, additional, Martin, Nicholas G., additional, Mata, Ignacio, additional, Mathew, Christopher G., additional, Mattheisen, Manuel, additional, Mattingsdal, Morten, additional, Mayoral, Fermin, additional, McCann, Owen T., additional, McCarley, Robert W., additional, McCarroll, Steven A., additional, McCarthy, Mark I., additional, McDonald, Colm, additional, McElroy, Susan L., additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McIntosh, Andrew M., additional, McKay, James D., additional, McMahon, Francis J., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Meier, Sandra, additional, Meijer, Carin J., additional, Melegh, Bela, additional, Melle, Ingrid, additional, Meng, Fan, additional, Mesholam-Gately, Raquelle I., additional, Metspalu, Andres, additional, Michie, Patricia T., additional, Milani, Lili, additional, Milanova, Vihra, additional, Mitchell, Philip B., additional, Mokrab, Younes, additional, Montgomery, Grant W., additional, Moran, Jennifer L., additional, Morken, Gunnar, additional, Morris, Derek W., additional, Mors, Ole, additional, Mortensen, Preben B., additional, Mowry, Bryan J., additional, Mühleisen, Thomas W., additional, Müller-Myhsok, Bertram, additional, Murphy, Kieran C., additional, Murray, Robin M., additional, Myers, Richard M., additional, Myin-Germeys, Inez, additional, Neale, Benjamin M., additional, Nelis, Mari, additional, Nenadic, Igor, additional, Nertney, Deborah A., additional, Nestadt, Gerald, additional, Nicodemus, Kristin K., additional, Nievergelt, Caroline M., additional, Nikitina-Zake, Liene, additional, Nimgaonkar, Vishwajit, additional, Nisenbaum, Laura, additional, Nordentoft, Merete, additional, Nordin, Annelie, additional, Nöthen, Markus M., additional, Nwulia, Evaristus A., additional, O’Callaghan, Eadbhard, additional, O’Donovan, Claire, additional, O’Dushlaine, Colm, additional, O’Neill, F. Anthony, additional, Oedegaard, Ketil J., additional, Oh, Sang-Yun, additional, Olincy, Ann, additional, Olsen, Line, additional, Oruc, Lilijana, additional, Van Os, Jim, additional, Owen, Michael J., additional, Paciga, Sara A., additional, Palmer, Colin N.A., additional, Palotie, Aarno, additional, Pantelis, Christos, additional, Papadimitriou, George N., additional, Parkhomenko, Elena, additional, Pato, Carlos, additional, Pato, Michele T., additional, Paunio, Tiina, additional, Pearson, Richard, additional, Perkins, Diana O., additional, Perlis, Roy H., additional, Perry, Amy, additional, Pers, Tune H., additional, Petryshen, Tracey L., additional, Pfennig, Andrea, additional, Picchioni, Marco, additional, Pietilainen, Olli, additional, Pimm, Jonathan, additional, Pirinen, Matti, additional, Plomin, Robert, additional, Pocklington, Andrew J., additional, Posthuma, Danielle, additional, Potash, James B., additional, Potter, Simon C., additional, Powell, John, additional, Price, Alkes, additional, Pulver, Ann E., additional, Purcell, Shaun M., additional, Quested, Digby, additional, Ramos-Quiroga, Josep Antoni, additional, Rasmussen, Henrik B., additional, Rautanen, Anna, additional, Ravindrarajah, Radhi, additional, Regeer, Eline J., additional, Reichenberg, Abraham, additional, Reif, Andreas, additional, Reimers, Mark A., additional, Ribases, Marta, additional, Rice, John P., additional, Richards, Alexander L., additional, Ricketts, Michelle, additional, Riley, Brien P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roffman, Joshua L., additional, Rouleau, Guy A., additional, Roussos, Panos, additional, Rujescu, Dan, additional, Salomaa, Veikko, additional, Sanchez-Mora, Cristina, additional, Sanders, Alan R., additional, Sawcer, Stephen J., additional, Schall, Ulrich, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schofield, Peter R., additional, Schork, Nicholas J., additional, Schwab, Sibylle G., additional, Scolnick, Edward M., additional, Scott, Laura J., additional, Scott, Rodney J., additional, Seidman, Larry J., additional, Serretti, Alessandro, additional, Sham, Pak C., additional, Weickert, Cynthia Shannon, additional, Shehktman, Tatyana, additional, Shi, Jianxin, additional, Shilling, Paul D., additional, Sigurdsson, Engilbert, additional, Silverman, Jeremy M., additional, Sim, Kang, additional, Slaney, Claire, additional, Slominsky, Petr, additional, Smeland, Olav B., additional, Smoller, Jordan W., additional, So, Hon-Cheong, additional, Sobell, Janet L., additional, Soderman, Erik, additional, Hansen, Christine Soholm, additional, Spencer, Chris C.A., additional, Spijker, Anne T., additional, St Clair, David, additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Steinberg, Stacy, additional, Stogmann, Elisabeth, additional, Stordal, Eystein, additional, Strange, Amy, additional, Straub, Richard E., additional, Strauss, John S., additional, Streit, Fabian, additional, Strengman, Eric, additional, Strohmaier, Jana, additional, Stroup, T. Scott, additional, Su, Zhan, additional, Subramaniam, Mythily, additional, Suvisaari, Jaana, additional, Svrakic, Dragan M., additional, Szatkiewicz, Jin P., additional, Szelinger, Szabolcs, additional, Tashakkori-Ghanbaria, Avazeh, additional, Thirumalai, Srinivas, additional, Thompson, Robert C., additional, Thorgeirsson, Thorgeir E., additional, Toncheva, Draga, additional, Tooney, Paul A., additional, Tosato, Sarah, additional, Toulopoulou, Timothea, additional, Trembath, Richard C., additional, Treutlein, Jens, additional, Turecki, Gustavo, additional, Vaaler, Arne E., additional, Vedder, Helmut, additional, Vieta, Eduard, additional, Vincent, John, additional, Visscher, Peter M., additional, Viswanathan, Ananth C., additional, Vukcevic, Damjan, additional, Waddington, John, additional, Waller, Matthew, additional, Walsh, Dermot, additional, Walshe, Muriel, additional, Walters, James T.R., additional, Wang, Dai, additional, Wang, Qiang, additional, Wang, Weiqing, additional, Wang, Yunpeng, additional, Watson, Stanley J., additional, Webb, Bradley T., additional, Weickert, Thomas W., additional, Weinberger, Daniel R., additional, Weisbrod, Matthias, additional, Weiser, Mark, additional, Werge, Thomas, additional, Weston, Paul, additional, Whittaker, Pamela, additional, Widaa, Sara, additional, Wiersma, Durk, additional, Wildenauer, Dieter B., additional, Williams, Nigel M., additional, Williams, Stephanie, additional, Witt, Stephanie H., additional, Wolen, Aaron R., additional, Wong, Emily H.M., additional, Wood, Nicholas W., additional, Wormley, Brandon K., additional, Wu, Jing Qin, additional, Xi, Simon, additional, Xu, Wei, additional, Young, Allan H., additional, Zai, Clement C., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zheng, Xuebin, additional, Zimprich, Fritz, additional, Zollner, Sebastian, additional, Corvin, Aiden, additional, Fanous, Ayman H., additional, Cichon, Sven, additional, Rietschel, Marcella, additional, Gershon, Elliot S., additional, Schulze, Thomas G., additional, Cuellar-Barboza, Alfredo B., additional, Forstner, Andreas J., additional, Holmans, Peter A., additional, Nurnberger, John I., additional, Andreassen, Ole A., additional, Lee, S. Hong, additional, O’Donovan, Michael C., additional, Sullivan, Patrick F., additional, Ophoff, Roel A., additional, Wray, Naomi R., additional, Sklar, Pamela, additional, and Kendler, Kenneth S., additional

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2018
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