Search

Your search keyword '"Origuchi, Tomoki"' showing total 898 results
Start Over Author "Origuchi, Tomoki"
898 results on '"Origuchi, Tomoki"'

1. Evaluating the safety profile of calcineurin inhibitors: cancer risk in patients with systemic lupus erythematosus from the LUNA registry—a historical cohort study

Author

Ichinose, Kunihiro, Sato, Shuntaro, Igawa, Takashi, Okamoto, Momoko, Takatani, Ayuko, Endo, Yushiro, Tsuji, Sosuke, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Yajima, Nobuyuki, Sada, Ken-Ei, Miyawaki, Yoshia, Yoshimi, Ryusuke, Shimojima, Yasuhiro, Ohno, Shigeru, Kajiyama, Hiroshi, Sato, Shuzo, Fujiwara, Michio, and Kawakami, Atsushi

Published
2024
Full Text
View/download PDF

4. Influences of advanced age in rheumatoid arthritis: A multicentre ultrasonography cohort study.

Author

Kawahara, Chieko, Fukui, Shoichi, Michitsuji, Tohru, Nishino, Ayako, Endo, Yushiro, Shimizu, Toshimasa, Umeda, Masataka, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Origuchi, Tomoki, Ueki, Yukitaka, Eiraku, Nobutaka, Suzuki, Takahisa, Okada, Akitomo, Matsuoka, Naoki, Takaoka, Hirokazu, Hamada, Hiroaki, Tsuru, Tomomi, and Arinobu, Yojiro

Subjects
WRIST joint, DOPPLER ultrasonography, MULTIPLE regression analysis, ANTIRHEUMATIC agents, ULTRASONIC imaging, RHEUMATOID arthritis
Abstract

Objectives: We aimed to evaluate the effects of age on clinical characteristics and outcomes in biologic or targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD)-naïve patients with rheumatoid arthritis (RA). Methods: We analysed the cases of 234 Japanese b/tsDMARD-naïve RA patients who underwent b/tsDMARD treatment in a multicentre ultrasound prospective observational cohort. We compared the clinical characteristics at baseline and outcomes at 12 months between those aged ≥60 years and those <60 years. Results: Compared to the <60-year-old group (n = 78), the ≥60-year-old group (n = 156) had higher inflammatory marker values and ultrasound combined scores, especially wrist joints, at baseline. Age at baseline positively correlated significantly with the ultrasound scores at baseline; however, age was not a significant variable by the multiple regression analysis. The patients treated with different MOAs in the ≥60-year-old group had comparable outcomes and multiple regression analysis revealed that mechanism of action (MOA) was not a significant contributor to the Clinical Disease Activity Index at 12 months. Conclusions: RA patients with advanced age demonstrated distinctive clinical characteristics. The MOAs were not associated with clinical outcomes and ultrasound outcomes in RA patients with advanced age. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Patient’s age and d-dimer levels predict the prognosis in patients with TAFRO syndrome

Author

Kawabata, Hiroshi, Fujimoto, Shino, Sakai, Tomoyuki, Yanagisawa, Hiroto, Kitawaki, Toshio, Nara, Kenji, Hagihara, Masao, Yamamoto, Hiroshi, Tanimizu, Masakuni, Kato, Chikako, Origuchi, Tomoki, Sunami, Kazutaka, Sunami, Yoshitaka, Masunari, Taro, Nakamura, Nobuhiko, Kobayashi, Masanori, Yamagami, Keiko, Miura, Katsuhiro, Takai, Kazue, Aoki, Sadao, Tsukamoto, Norifumi, and Masaki, Yasufumi

Published
2021
Full Text
View/download PDF

7. The impact of glucocorticoid use on the outcomes of rheumatoid arthritis in a multicenter ultrasound cohort study

Author

Nonaka, Fumiaki, primary, Fukui, Shoichi, additional, Michitsuji, Tohru, additional, Endo, Yushiro, additional, Nishino, Ayako, additional, Shimizu, Toshimasa, additional, Umeda, Masataka, additional, Sumiyoshi, Remi, additional, Koga, Tomohiro, additional, Iwamoto, Naoki, additional, Origuchi, Tomoki, additional, Ueki, Yukitaka, additional, Eiraku, Nobutaka, additional, Suzuki, Takahisa, additional, Okada, Akitomo, additional, Matsuoka, Naoki, additional, Takaoka, Hirokazu, additional, Hamada, Hiroaki, additional, Tsuru, Tomomi, additional, Arinobu, Yojiro, additional, Hidaka, Toshihiko, additional, Fujikawa, Keita, additional, Yoshitama, Tamami, additional, Tada, Yoshifumi, additional, Ohtsubo, Hideo, additional, Ishizaki, Jun, additional, Asano, Tomoyuki, additional, Maeda, Takahiro, additional, Kawakami, Atsushi, additional, and Kawashiri, Shin‐ya, additional

Published
2024
Full Text
View/download PDF

8. Successful treatment of systemic lupus erythematosus with residual disease activity by switching from belimumab to anifrolumab.

Author

Umeda, Masataka, Kojima, Kanako, Michitsuji, Toru, Tsuji, Yoshika, Shimizu, Toshimasa, Fukui, Shoichi, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Naoki, Iwamoto, Iagawa, Takashi, Tamai, Mami, Origuchi, Tomoki, Furuyama, Masako, Tsuboi, Masahiko, Matsuoka, Naoki, Okada, Akitomo, Aramaki, Toshiyuki, and Kawakami, Atsushi

Subjects
B cell receptors, MEDICAL sciences, IMMUNOLOGIC memory, TYPE I interferons, COLLEGE graduates
Abstract

The article in Modern Rheumatology discusses the successful treatment of systemic lupus erythematosus (SLE) with residual disease activity by switching from belimumab to anifrolumab. The study conducted a retrospective analysis of 22 SLE patients who transitioned from belimumab to anifrolumab, showing significant reductions in SLE disease activity index scores and glucocorticoid usage. The switch to anifrolumab resulted in improvements in various SLE symptoms and signs, with a favorable safety profile and high treatment retention rates observed. The study suggests that switching to anifrolumab may be beneficial for addressing residual disease activity in SLE patients. [Extracted from the article]

Published
2024
Full Text
View/download PDF

10. Granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-α in combination is a useful diagnostic biomarker to distinguish familial Mediterranean fever from sepsis

Author

Koga, Tomohiro, Furukawa, Kaori, Migita, Kiyoshi, Morimoto, Shimpei, Shimizu, Toshimasa, Fukui, Shoichi, Umeda, Masataka, Endo, Yushiro, Sumiyoshi, Remi, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Origuchi, Tomoki, Maeda, Takahiro, Yachie, Akihiro, and Kawakami, Atsushi

Published
2021
Full Text
View/download PDF

11. Association between serum bone biomarker levels and therapeutic response to abatacept in patients with rheumatoid arthritis (RA): a multicenter, prospective, and observational RA ultrasound cohort study in Japan

Author

Kawashiri, Shin-ya, Endo, Yushiro, Nishino, Ayako, Okamoto, Momoko, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Aramaki, Toshiyuki, Ueki, Yukitaka, Yoshitama, Tamami, Eiraku, Nobutaka, Matsuoka, Naoki, Okada, Akitomo, Fujikawa, Keita, Hamada, Hiroaki, Nagano, Shuji, Tada, Yoshifumi, and Kawakami, Atsushi

Published
2021
Full Text
View/download PDF

12. Real-world comparative effectiveness and safety of tofacitinib and baricitinib in patients with rheumatoid arthritis

Author

Iwamoto, Naoki, Sato, Shuntaro, Kurushima, Shota, Michitsuji, Toru, Nishihata, Shinya, Okamoto, Momoko, Tsuji, Yoshika, Endo, Yushiro, Shimizu, Toshimasa, Sumiyoshi, Remi, Suzuki, Takahisa, Okada, Akitomo, Koga, Tomohiro, Kawashiri, Shin-ya, Fujikawa, Keita, Igawa, Takashi, Aramaki, Toshiyuki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Mizokami, Akinari, Origuchi, Tomoki, Ueki, Yukitaka, Eguchi, Katsumi, and Kawakami, Atsushi

Published
2021
Full Text
View/download PDF

13. IgG4-related disease in the Japanese population: a genome-wide association study

Author

Kanno, Atsushi, Okabe, Yoshihiro, Katsushima, Shinji, Inokuma, Tetsuro, Yamashita, Yukitaka, Nakai, Yoshitaka, Nishino, Takayoshi, Kajimura, Kozo, Shibatoge, Mitsushige, Kanda, Naoki, Ido, Akio, Ohana, Masaya, Moriyama, Ichiro, Tatsuta, Hiroshi, Matsumura, Kazuyoshi, Fujikawa, Keita, Gotoh, Norimoto, Tsutsumi, Takanobu, Shimizu, Masakazu, Setoh, Kazuya, Takahashi, Meiko, Tabara, Yasuharu, Mimura, Jun, Nakamura, Takefumi, Kimura, Toshiyuki, Kawanami, Chiharu, Terao, Chikashi, Ota, Masao, Iwasaki, Takeshi, Shiokawa, Masahiro, Kawaguchi, Shuji, Kuriyama, Katsutoshi, Kawaguchi, Takahisa, Kodama, Yuzo, Yamaguchi, Izumi, Uchida, Kazushige, Higasa, Koichiro, Yamamoto, Motohisa, Kubota, Kensuke, Yazumi, Shujiro, Hirano, Kenji, Masaki, Yasufumi, Maguchi, Hiroyuki, Origuchi, Tomoki, Matsui, Shoko, Nakazawa, Takahiro, Shiomi, Hideyuki, Kamisawa, Terumi, Hasebe, Osamu, Iwasaki, Eisuke, Inui, Kazuo, Tanaka, Yoshiya, Ohshima, Koh-ichi, Akamizu, Takashi, Nakamura, Shigeo, Nakamura, Seiji, Saeki, Takako, Umehara, Hisanori, Shimosegawa, Tooru, Mizuno, Nobumasa, Kawano, Mitsuhiro, Azumi, Atsushi, Takahashi, Hiroki, Mimori, Tsuneyo, Kamatani, Yoichiro, Okazaki, Kazuichi, Chiba, Tsutomu, Kawa, Shigeyuki, and Matsuda, Fumihiko

Published
2019
Full Text
View/download PDF

14. Effects of Cryotherapy Applied at Different Temperatures on Inflammatory Pain During the Acute Phase of Arthritis in Rats

Author

Sasaki, Ryo, Sakamoto, Junya, Kondo, Yasutaka, Oga, Satoshi, Takeshita, Idumi, Honda, Yuichiro, Kataoka, Hideki, Origuchi, Tomoki, and Okita, Minoru

Subjects
Acute phase reaction -- Care and treatment -- Models, Cold -- Health aspects, Arthritis -- Care and treatment -- Models
Abstract

Objective. The biological mechanisms of cryotherapy for managing acute pain remain unclear. Additionally, it is unknown whether the effectiveness of cryotherapy depends on the applied temperature. This study aimed to clarify the biological effects of cryotherapy and to examine the therapeutic effects of cryotherapy applied at different temperatures in rats. Methods. This was an experimental study using a rat knee joint arthritis model. Thirty-five Wistar rats were randomly divided into arthritis (AR), arthritis with 5 ([degrees]) C cryotherapy (CR-5), arthritis with 10 ([degrees]) C cryotherapy (CR-10), and sham-arthritis control (CON) groups. Arthritis was induced by injecting a mixture of kaolin/carrageenan into the right knee joint. Cryotherapy was applied for 7 days starting the day after injection by immersing the right knee joint in 5 ([degrees]) C or 10 ([degrees]) C water. Joint transverse diameter, pressure pain threshold, and pain-related behaviors were assessed for 7 days. The number of CD68-positive cells in the knee joint and the expression of calcitonin gene-related peptide in the spinal dorsal horn 8 days after injection were analyzed by immunohistochemical staining. Results. Improvements in transverse diameter, pressure pain threshold, and pain-related behaviors were observed in the CR-5 and CR-10 groups on the 3rd day compared with the AR group. The number of CD68-positive cells and the expression of calcitonin gene-related peptide in the CR-5 and CR-10 groups were significantly decreased compared with the AR group. There were no significant differences in all results between the CR-5 and CR-10 groups. Conclusions. Cryotherapy can ameliorate inflammatory pain through reduction of synovium and central sensitization. Additionally, the effects of cryotherapy lower than 10 ([degrees]) C are observed independent of applied temperature. Impact. Cryotherapy may be beneficial as a physical therapy modality for pain and swelling management in the acute phase of inflammation. Translational human study is needed to determine the effective cryotherapy temperature for the inflammatory pain. Keywords: Acute Pain, Animal, Arthritis, Inflammation, Models, Pain Management, Physical Therapy Modalities, Introduction Inflammation evoked by trauma, arthritis, and surgical procedures is a self-protective reaction to remove harmful stimuli and begin the healing process. (1) At the peripheral tissue level, inflammation is [...]

Published
2021
Full Text
View/download PDF

15. Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis

Author

Terao, Chikashi, Yoshifuji, Hajime, Matsumura, Takayoshi, Naruse, Taeko K., Ishii, Tomonori, Nakaoka, Yoshikazu, Kirino, Yohei, Matsuo, Keitaro, Origuchi, Tomoki, Shimizu, Masakazu, Maejima, Yasuhiro, Amiya, Eisuke, Tamura, Natsuko, Kawaguchi, Takahisa, Takahashi, Meiko, Setoh, Kazuya, Ohmura, Koichiro, Watanabe, Ryu, Horita, Tetsuya, Atsumi, Tatsuya, Matsukura, Mitsuru, Miyata, Tetsuro, Kochi, Yuta, Suda, Toshio, Tanemoto, Kazuo, Meguro, Akira, Okada, Yukinori, Ogimoto, Akiyoshi, Yamamoto, Motohisa, Takahashi, Hiroki, Nakayamada, Shingo, Saito, Kazuyoshi, Kuwana, Masataka, Mizuki, Nobuhisa, Tabara, Yasuharu, Ueda, Atsuhisa, Komuro, Issei, Kimura, Akinori, Isobe, Mitsuaki, Mimori, Tsuneyo, and Matsuda, Fumihiko

Published
2018

16. Podocyte foot process width is a prediction marker for complete renal response at 6 and 12 months after induction therapy in lupus nephritis

Author

Ichinose, Kunihiro, Kitamura, Mineaki, Sato, Shuntaro, Fujikawa, Keita, Horai, Yoshiro, Matsuoka, Naoki, Tsuboi, Masahiko, Nonaka, Fumiaki, Shimizu, Toshimasa, Fukui, Shoichi, Umeda, Masataka, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nishino, Tomoya, and Kawakami, Atsushi

Published
2018
Full Text
View/download PDF

17. Novel anti-suprabasin antibodies may contribute to the pathogenesis of neuropsychiatric systemic lupus erythematosus

Author

Ichinose, Kunihiro, Ohyama, Kaname, Furukawa, Kaori, Higuchi, Osamu, Mukaino, Akihiro, Satoh, Katsuya, Nakane, Shunya, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Nakajima, Hideki, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Yoshida, Mari, Kuroda, Naotaka, and Kawakami, Atsushi

Published
2018
Full Text
View/download PDF

18. CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus

Author

Umeda, Masataka, Koga, Tomohiro, Ichinose, Kunihiro, Igawa, Takashi, Sato, Tomohito, Takatani, Ayuko, Shimizu, Toshimasa, Fukui, Shoichi, Nishino, Ayako, Horai, Yoshiro, Hirai, Yasuko, Kawashiri, Shin-ya, Iwamoto, Naoki, Aramaki, Toshiyuki, Tamai, Mami, Nakamura, Hideki, Yamamoto, Kazuo, Abiru, Norio, Origuchi, Tomoki, Ueki, Yukitaka, and Kawakami, Atsushi

Published
2018
Full Text
View/download PDF

19. Denosumab is effective toward glucocorticoid-induced osteoporosis patients complicated with rheumatic diseases regardless of prior anti-osteoporotic drugs

Author

Iwamoto, Naoki, Okamoto, Momoko, Tsuji, Sosuke, Endo, Yushiro, Takatani, Ayuko, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Sumiyoshi, Remi, Igawa, Takashi, Koga, Tomohiro, Kawashiri, Shin-ya, Aramaki, Toshiyuki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Eguchi, Katsumi, Ueki, Yukitaka, and Kawakami, Atsushi

Published
2019
Full Text
View/download PDF

20. Correction to: Patient’s age and D‑dimer levels predict the prognosis in patients with TAFRO syndrome

Author

Kawabata, Hiroshi, Fujimoto, Shino, Sakai, Tomoyuki, Yanagisawa, Hiroto, Kitawaki, Toshio, Nara, Kenji, Hagihara, Masao, Yamamoto, Hiroshi, Tanimizu, Masakuni, Kato, Chikako, Origuchi, Tomoki, Sunami, Kazutaka, Sunami, Yoshitaka, Masunari, Taro, Nakamura, Nobuhiko, Kobayashi, Masanori, Yamagami, Keiko, Miura, Katsuhiro, Takai, Kazue, Aoki, Sadao, Tsukamoto, Norifumi, and Masaki, Yasufumi

Published
2021
Full Text
View/download PDF

21. IgG4-related respiratory disease: a retrospective study of 115 patients

Author

Matsui, Shoko, primary, Yamamoto, Hiroshi, additional, Minamoto, Seijiro, additional, Handa, Tomohiro, additional, Waseda, Yuko, additional, Matsui, Aki, additional, Komatsu, Masamichi, additional, Okazawa, Seisuke, additional, Hebisawa, Akira, additional, Yamamoto, Motohisa, additional, Takahashi, Hiroki, additional, Umeda, Masataka, additional, Origuchi, Tomoki, additional, and Saeki, Takako, additional

Published
2023
Full Text
View/download PDF

22. Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort

Author

Ichinose, Kunihiro, Kitamura, Mineaki, Sato, Shuntaro, Fujikawa, Keita, Horai, Yoshiro, Matsuoka, Naoki, Tsuboi, Masahiko, Nonaka, Fumiaki, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nishino, Tomoya, and Kawakami, Atsushi

Published
2020
Full Text
View/download PDF

23. Comparison of lung microbiota between antineutrophil cytoplasmic antibody-associated vasculitis and sarcoidosis

Author

Fukui, Shoichi, Morimoto, Shimpei, Ichinose, Kunihiro, Nakashima, Shota, Ishimoto, Hiroshi, Hara, Atsuko, Kakugawa, Tomoyuki, Sakamoto, Noriho, Tsuji, Yoshika, Aramaki, Toshiyuki, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Ueki, Yukitaka, Suzuki, Shino, Mukae, Hiroshi, and Kawakami, Atsushi

Published
2020
Full Text
View/download PDF

24. Interleukin-18 and fibroblast growth factor 2 in combination is a useful diagnostic biomarker to distinguish adult-onset Still’s disease from sepsis

Author

Koga, Tomohiro, Sumiyoshi, Remi, Furukawa, Kaori, Sato, Shuntaro, Migita, Kiyoshi, Shimizu, Toshimasa, Umeda, Masataka, Endo, Yushiro, Fukui, Shoichi, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nonaka, Fumiaki, Yachie, Akihiro, Kondo, Hideaki, Maeda, Takahiro, and Kawakami, Atsushi

Published
2020
Full Text
View/download PDF

26. Utility of a simplified ultrasonography scoring system among patients with rheumatoid arthritis: A multicenter cohort study

Author

Endo, Yushiro, Kawashiri, Shin-ya, Morimoto, Shimpei, Nishino, Ayako, Okamoto, Momoko, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Koga, Tomohiro, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Ueki, Yukitaka, Yoshitama, Tamami, Eiraku, Nobutaka, Matsuoka, Naoki, Okada, Akitomo, Fujikawa, Keita, Otsubo, Hideo, Takaoka, Hirokazu, Hamada, Hiroaki, Tsuru, Tomomi, Nagano, Shuji, Yojiro, Arinobu, Hidaka, Toshihiko, Tada, Yoshifumi, and Kawakami, Atsushi

Published
2021
Full Text
View/download PDF

27. Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review

Author

Origuchi, Tomoki, primary, Uchida, Tomohisa, additional, Sakaguchi, Tatsuki, additional, Matsuo, Haruna, additional, Michitsuji, Toru, additional, Umeda, Masataka, additional, Shimizu, Toshimasa, additional, Koga, Tomohiro, additional, Kawashiri, Shin-Ya, additional, Iwamoto, Naoki, additional, Ichinose, Kunihiro, additional, Tamai, Mami, additional, Ichinose, Masahiro, additional, Ando, Koji, additional, Horie, Ichiro, additional, Nakao, Nobuhiro, additional, Irie, Junji, additional, and Kawakami, Atsushi, additional

Published
2023
Full Text
View/download PDF

33. Serum levels of fibroblast growth factor-2 distinguish Takayasu arteritis from giant cell arteritis independent of age at diagnosis

Author

Fukui, Shoichi, Kuwahara-Takaki, Ayako, Ono, Nobuyuki, Sato, Shuntaro, Koga, Tomohiro, Kawashiri, Shin-ya, Iwanaga, Nozomi, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Migita, Kiyoshi, Arinobu, Yojiro, Niiro, Hiroaki, Tada, Yoshifumi, Akashi, Koichi, Maeda, Takahiro, and Kawakami, Atsushi

Published
2019
Full Text
View/download PDF

34. The double shared epitope: Its impact on clinical features and ultrasound findings in rheumatoid arthritis.

Author

Michitsuji, Tohru, Fukui, Shoichi, Nishino, Ayako, Endo, Yushiro, Furukawa, Kaori, Shimizu, Toshimasa, Umeda, Masataka, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Origuchi, Tomoki, Kawakami, Atsushi, and Kawashiri, Shin‐ya

Subjects
RHEUMATOID arthritis, GENOME-wide association studies, DISEASE remission, ULTRASONIC imaging, GRAYSCALE model
Abstract

Objectives: The link between the HLA‐DRB1 locus and the risk of rheumatoid arthritis (RA) shown in genome‐wide association studies strengthens the shared epitope (SE) hypothesis. We aimed to assess the impact of the double dose of the SE (double SE) on RA and explore its clinical associations, including the response to abatacept. Methods: We evaluated RA patients treated with csDMARDs or abatacept for HLA‐DRB1 typing, clinical characteristics at baseline, and disease activity and ultrasound findings over 12 months. Results: Patients with the double SE (n = 12) had significantly higher anti‐citrullinated protein antibody (ACPA) titers, higher total grayscale (GS) score, and power Doppler (PD) score at baseline than patients without the double SE. Patients with the double SE exhibited reduced rates of SDAI remission and pronounced improvements in multiple disease activity between baseline and 12 months, including SDAI, CDAI, total GS score, and total PD score. When focusing on abatacept‐treated patients, the decreases in SDAI, CDAI, and total PD score between baseline and 12 months were significantly larger in patients with the double SE. Conclusions: Patients with the double SE exhibited distinct characteristics, increased disease activity, and improved response to abatacept treatment. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

35. Association of FTO genotype with obesity and bone health among communitydwelling adults ; Goto Island study on bone health

Author

Xiao, Xu, Mizukami, Satoshi, Arima, Kazuhiko, Morikawa, Kyoya, Motoi, Midori, Iwamoto, Naoki, Tomita, Yoshihito, Uchiyama, Michiko, Honda, Yuzo, Tanaka, Natsumi, Goto, Hisashi, Hasegawa, Maiko, Sou, Youko, Tsujimoto, Ritsu, Nishimura, Takayuki, Kawashiri, Shin-ya, Tamai, Mami, Yamanashi, Hirotomo, Abe, Yasuyo, Origuchi, Tomoki, Nagata, Yasuhiro, Kawakami, Atsushi, Maeda, Takahiro, and Aoyagi, Kiyoshi

Subjects
Bone ultrasound, Human association studies, General population studies, Osteoporosis, FTO gene
Abstract

Bone mass is tuned by various factors, including aging, menopause, low body weight, and genetic variations. Here, we showed an independent association between a genotype on the fat mass- and obesity-associated FTO gene (#610966 on OMIM) and bone loss after adjusting for age and body mass index (BMI). A cross-sectional study was nested in a prospective observational study of 1,828 participants (median age: 69 [62-76] years in men and 68 [61-75] years in women) residing in a rural city in western Japan (Goto Island study). Participants were recruited during medical checkups in 2014 and 2016 from the community-dwelling population. The bone mass of the calcaneus was evaluated using quantitative ultrasound. The single nucleotide polymorphism (SNP) rs1421085 was genotyped using a hydrolysis probe. The chi-squared test was used to determine whether the variants were in equilibrium in this population. There were differences in medians of BMI among the genotypes (24.3 in CC, 23.0 in CT, and 22.6 in TT, P = 0.01), but not in those of bone mass. There was a significant association between the minor allele (C) and being overweight in a gene dosage-dependent manner (BMI > 25, OR per allele =1.52, 95% CI = 1.07-2.14, P = 0.02 in men, OR = 1.48, 95% CI = 1.16-1.95, P = 0.01 in women). Logistic regression analysis showed a significant protective association in male carriers of the minor allele against low bone mass (QUS T-score less than -2.0) after adjusting for age and BMI in men aged 65-75 years (OR = 0.50, 95% CI = 0.27-0.96, P = 0.036), with no significant association in women.Our study indicated an association between the genetic polymorphism of FTO and bone mass among community-dwelling men aged 65-75 years. The polymorphism may play a role in bone health with higher BMI and other beneficial functions., Acta medica Nagasakiensia, 65(3), pp.77-87; 2022

Published
2022

36. Subclinical inflammation in a case of menstruation-induced familial Mediterranean fever: A case report

Author

Hara, Kazusato, Endo, Yushiro, Ishida, Midori, Fujita, Yuya, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Migita, Kiyoshi, Kawakami, Atsushi, and Koga, Tomohiro

Published
2018
Full Text
View/download PDF

37. Recurrence of anti-MDA5 antibody-positive clinically amyopathic dermatomyositis after long-term remission: A case report

Author

Endo, Yushiro, Koga, Tomohiro, Ishida, Midori, Fujita, Yuya, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Kuwana, Masataka, Hosono, Yuji, Mimori, Tsuneyo, and Kawakami, Atsushi

Published
2018
Full Text
View/download PDF

39. Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan

Author

Endo, Yushiro, Koga, Tomohiro, Ishida, Midori, Fujita, Yuya, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Agematsu, Kazunaga, Yachie, Akihiro, Masumoto, Junya, Migita, Kiyoshi, and Kawakami, Atsushi

Published
2018
Full Text
View/download PDF

42. Prediction of radiographic progression during a treat-to-target strategy by the sequential application of MRI-proven bone marrow oedema and power-Doppler grade ≥2 articular synovitis in rheumatoid arthritis: Retrospective observational study

Author

Takatani, Ayuko, primary, Tamai, Mami, additional, Ohki, Nozomi, additional, Okamoto, Momoko, additional, Endo, Yushiro, additional, Tsuji, Sousuke, additional, Shimizu, Toshimasa, additional, Umeda, Masataka, additional, Fukui, Shoichi, additional, Sumiyoshi, Remi, additional, Nishino, Ayako, additional, Koga, Tomohiro, additional, Kawashiri, Shin-ya, additional, Iwamoto, Naoki, additional, Igawa, Takashi, additional, Ichinose, Kunihiro, additional, Arima, Kazuhiko, additional, Nakamura, Hideki, additional, Origuchi, Tomoki, additional, Uetani, Masataka, additional, and Kawakami, Atsushi, additional

Published
2022
Full Text
View/download PDF

43. Prediction of radiographic progression during a treat-to-target strategy by the sequential application of MRI-proven bone marrow oedema and power-Doppler grade ≥2 articular synovitis in rheumatoid arthritis: Retrospective observational study

Author

Takatani, Ayuko, Tamai, Mami, Ohki, Nozomi, Okamoto, Momoko, Endo, Yushiro, Tsuji, Sousuke, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Sumiyoshi, Remi, Nishino, Ayako, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Ichinose, Kunihiro, Arima, Kazuhiko, Nakamura, Hideki, Origuchi, Tomoki, Uetani, Masataka, Kawakami, Atsushi, Takatani, Ayuko, Tamai, Mami, Ohki, Nozomi, Okamoto, Momoko, Endo, Yushiro, Tsuji, Sousuke, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Sumiyoshi, Remi, Nishino, Ayako, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Ichinose, Kunihiro, Arima, Kazuhiko, Nakamura, Hideki, Origuchi, Tomoki, Uetani, Masataka, and Kawakami, Atsushi

Abstract

Objectives: To investigate the appropriate timing, useful findings and combination of magnetic resonance imaging (MRI) and ultrasound (US) for predicting the radiographic progression in early rheumatoid arthritis (RA). Methods:Forty-four active RA patients, who examined by both of MRI and US in the symptomatic wrist and finger joints, were recruited in Nagasaki University Hospital from 2010 to 2017 and treated by the treat-to-target therapeutic strategy for 1 year. MRI was evaluated by RA MRI scoring and US by Outcomes Measures in Rheumatology Clinical Trial, respectively. Plain radiographs were assessed by the Genant-modified Sharp score for the symptomatic side in the same manner as MRI and US. Radiographic progression was defined as an annual increase ≥0.75 at 1 year. Factors associated with radiographic progression were analysed. Also, the optimal combination of MRI and US at each timepoint was considered. Results:Logistic regression model revealed that MRI-proven bone marrow oedema at baseline and 6 months and joint counts of power-Doppler grade ≥2 articular synovitis at 3 or 6 months were significantly associated with radiographic progression at 1 year. Conclusion:This study may suggest the favourable timing and combination of MRI and US at each point to predict radiographic progression in patients with early-stage RA., Modern rheumatology, 33(4), pp.708-714; 2023

Published
2022

44. Comparison of complications during 1-year follow-up between remitting seronegative symmetrical synovitis with pitting edema syndrome and elderly-onset rheumatoid arthritis

Author

Origuchi, Tomoki, primary, Umeda, Masataka, additional, Koga, Tomohiro, additional, Kawashiri, Shin-ya, additional, Iwamoto, Naoki, additional, Ichinose, Kunihiro, additional, Tamai, Mami, additional, Tsukada, Toshiaki, additional, Miyashita, Taiichiro, additional, Iwanaga, Nozomi, additional, Horai, Yoshiro, additional, Arima, Kazuhiko, additional, Aramaki, Toshiyuki, additional, Ueki, Yukitaka, additional, Eguchi, Katsumi, additional, and Kawakami, Atsushi, additional

Published
2022
Full Text
View/download PDF

45. Clinical Characteristics of Patients With IgG4-Related Disease Complicated by Hypocomplementemia

Author

Fujita, Yuya, primary, Fukui, Shoichi, additional, Umeda, Masataka, additional, Tsuji, Sosuke, additional, Iwamoto, Naoki, additional, Nakashima, Yoshikazu, additional, Horai, Yoshiro, additional, Suzuki, Takahisa, additional, Okada, Akitomo, additional, Aramaki, Toshiyuki, additional, Ueki, Yukitaka, additional, Mizokami, Akinari, additional, Origuchi, Tomoki, additional, Watanabe, Hiroshi, additional, Migita, Kiyoshi, additional, and Kawakami, Atsushi, additional

Published
2022
Full Text
View/download PDF

47. Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function

Author

Ichinose, Kunihiro, Ushigusa, Takeshi, Nishino, Ayako, Nakashima, Yosikazu, Suzuki, Takahisa, Horai, Yoshiro, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Tamai, Mami, Arima, Kazuhiko, Nakamura, Hideki, Obata, Yoko, Yamamoto, Kazuo, Origuchi, Tomoki, Nishino, Tomoya, Kawakami, Atsushi, and Tsokos, George C.

Published
2016
Full Text
View/download PDF

48. Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis

Author

Saeki, Takako, Nishi, Shinichi, Imai, Naofumi, Ito, Tomoyuki, Yamazaki, Hajime, Kawano, Mitsuhiro, Yamamoto, Motohisa, Takahashi, Hiroki, Matsui, Shoko, Nakada, Shinji, Origuchi, Tomoki, Hirabayashi, Akira, Homma, Noriyuki, Tsubata, Yutaka, Takata, Takuma, Wada, Yoko, Saito, Akihiko, Fukase, Sachiko, Ishioka, Kunihiro, Miyazaki, Kana, Masaki, Yasufumi, Umehara, Hisanori, Sugai, Susumu, and Narita, Ichiei

Published
2010
Full Text
View/download PDF

50. Diminution du taux sérique de la protéine matricielle oligomérique du cartilage (COMP) chez des patients atteints de polyarthrite rhumatoïde et entrés en rémission après six mois de traitement par étanercept : comparaison avec CRP, IgM-FR, MMP-3 et Ac anti-CCP

Author

Kawashiri, Shin-ya, Kawakami, Atsushi, Ueki, Yukitaka, Imazato, Takahiro, Iwamoto, Naoki, Fujikawa, Keita, Aramaki, Toshiyuki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Ida, Hiroaki, and Eguchi, Katsumi

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results