98 results on '"Orkin B"'
Search Results
2. Cleft lift procedure for pilonidal disease: technique and perioperative management
- Author
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Favuzza, J., Brand, M., Francescatti, A., and Orkin, B.
- Published
- 2015
- Full Text
- View/download PDF
3. Repair of a colonoscopic perforation of the rectum with transanal endoscopic microsurgery
- Author
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Zhou, R. and Orkin, B. A.
- Published
- 2016
- Full Text
- View/download PDF
4. Perineal reconstruction with local flaps: technique and results
- Author
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Orkin, B. A.
- Published
- 2013
- Full Text
- View/download PDF
5. Planning, simulation and mission efficiency estimation of piloted and unmanned aerial vehicles in standard operations of their application
- Author
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Diyachuk, A K, primary, Orkin, B D, additional, and Orkin, S D, additional
- Published
- 2021
- Full Text
- View/download PDF
6. Interactive automated planning system for actions of aviation of different tactical designation against naval objects
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D’yachuk, A. K., Orkin, B. D., and Orkin, S. D.
- Published
- 2011
- Full Text
- View/download PDF
7. Formulation of methods for targeting anti-aircraft defense facilities of a ship group during simulation of an attack on the group by aircraft
- Author
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Orkin, B. D., Orkin, S. D., and Prokhorov, I. A.
- Published
- 2006
- Full Text
- View/download PDF
8. American Society of Colon and Rectal Surgeons 91st Annual Convention Podium and Poster abstracts: June 7–12, 1992 San Francisco, CA
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Lechner, P., Lind, P., Binter, G., Golub, R. W., Kerner, B. A., Wise, Jr., W. E., Meesig, D. M., Hartmann, R. F., Khanduja, K. S., Sayre, J. W., Aguilar, P. S., Guillem, J. G., Forde, K. A., Treat, M. R., Neugut, A. I., O'Toole, K. M., Diamond, B. E., Kewenter, J., Brevinge, H., Haglind, E., Limberg, B., Elles, C. N., Boggs, W. H., Slagle, G. H., Cole, P. A., Coyle, D. J., Smith, L. E., Orkin, B., Saclarides, T. J., Sheridan, W. G., Lowndes, R. H., Young, H. L., Wong, W. D., Rothenberger, D. A., Bartolo, D. C. C., Wexner, S. D., Ger, G. C., Jorge, J. M. N., Lee, E., Nogueras, J. J., Jagelman, D. G., McKenna, K., Koltun, W. A., Bute, B., Lichliter, W., Le, T., Timmcke, A., Gathright, J. B., Mascagni, D., Hojo, K., Moriya, Y., Sugihara, K., Di, G., Zenni, G. C., Abraham, K., Dobrin, P. B., Harford, F. J., Suzuki, K., Gunderson, L., Devine, R. M., Dozois, R. R., Cavaliere, F., Pemberton, J. H., Fazio, V., Cosimelli, M., Beart, R. W., Giannarelli, D., Moran, M., Ramos, A., Rothenberger, D., Goldberg, S., Antonenko, D., Heymen, S., Gulledge, A. D., Jakate, S., Saclarides, T., Heine, J. A., Williams, J. G., VanBergen, E. H., Buie, W. D., Goldberg, S. M., Davies, N., Yates, J., Jenkins, S. A., Taylor, B. A., Bapat, B., Stern, H., Berk, T., Parker, J., Ray, P. N., McLeod, R., Cohen, Z., Rowe, J. K., Zera, R. T., Madoff, R. D., Bubrick, M. P., Roberts, J. C., Johnston, G. R., Fenney, D. A., Farouk, R., Duthie, G. S., McCue, J. L., Phillips, R. K. S., Viamonte, M., Cole, J., Gottesman, L., Solomon, M. J., McLeod, R. S., Kern, K., Jensen, L. L., Lowry, A. C., Vernava, III, A. M., Longo, W. E., Daniel, G. L., Ehrenpreis, E., Stone, J. M., Cosman, B. C., Wolfe, V. A., Nino-Murcia, M., Perkash, I., Marcello, P. W., Roberts, P. L., Schoetz, Jr., D. J., Murray, J. J., Coller, J. A., Veidenheimer, M. C., Keighley, M. R. B., Grobler, S. P., Hosie, K. B., Schmitt, S. L., James, K., Lucas, F., Peck, Donald A., Ferrara, A., Grotz, R. L., Perry, R. E., Hanson, R. B., Lewis, W. G., Holdsworth, P. J., Sagar, P. M., Johnston, D., Perry, T. G., Strong, S. A., Fazio, V. W., Lavery, I. C., Oakley, J. R., Church, J. M., Milsom, J. W., Fozard, J. B. J., Nelson, H., Schneebaum, S., Arnold, M. W., Young, D., LaValle, G. J., Petty, L., Berens, A., Mojizisik, C., Martin, E. W., Hase, K., Shatney, C. H., Trollope, M., Johnson, D., Vierra, M., Deutsch, A. A., Tulchinsky, H., Nudelman, I., Gutman, H., Reiss, R., Taylor, Brian M., Araujo, A., Bleday, R., Jessurun, J., Heine, J., Rosen, Les, Sipe, Paul, Riether, Robert, Stasik, John, Sheets, James, Khubchandani, Indru, Reiter, W., Friedberg, G., Morey, G., Goldstein, E., Williamson, P., Larach, S., Senagore, A. J., Luchtefeld, M. A., MacKeigen, J. M., Mazier, W. P., Wengert, T., Ott, M. T., Bailey, H. R., Hartendorp, P., Dailey, T. H., Church, J. C., Johansen, O. B., Daniel, N., Korst, M., Kuijpers, H. C., Pena, J. P., Christenson, C. E., Balcos, E. G., Lewis, W., Mitchell, C., MacFie, J., Hildebrandt, U., Ecker, K. W., Kraus, J., Schmid, T., Feifel, G., Tjandra, J. J., Scoggin, Steve, Frazee, Richard C., Ambroze, Jr., W. L., Nezhat, C., Pennington, E., Nezhat, F., Stolfi, V. M., Thorson, A. G., Falk, P. M., Fitzgibbons, Jr, R. J., Luukkonen, P., Järvinen, H. J., James, E., Paty, P. B., Enker, W. E., Cohen, A. M., Lauwers, G. Y., Saad, R., Birnbaum, E., DeVos, W., Fry, R., Kodner, I., Fleshman, J., Cali, R. L., Pitsch, R. M., Blatchford, G. J., Christensen, M. A., Schroeder, T. K., Easley, K. A., Ellis, C. N., Cheape, J. D., Hull, T. L., Salanga, V., Kokoszka, Joseph, Andrianopoulos, Georgia, Nelson, Richard, Abcarian, Herand, Kumar, D., Benson, M. J., Roberts, J., Martin, J. E., Swash, M., Wingate, D. L., Williams, N. S., Orkin, B. A., Emsellem, H., Dent, John, Tissaw, M. A., Shafik, A., Abel, M. E., Chiu, Y. S. Y., Russell, T. R., Volpe, P. A., Casillas, G. L., Mashas, W. E., Eastman, D. A., Grace, R. H., Anderson, J. M., Hacker, K., Heryer, J., Conner, W., Rubin, R., Eisenstat, T., Salvati, E., Oliver, G., Duberman, E., Simmang, C. L., Fry, R. D., Kodner, I. J., Fleshman, J. W., Corman, M. L., Galandiuk, S., Weiner, G. J., Kahn, D., Mitchell, E., Abdel-Nabi, H., Block, G. E., Mannella, E., Tedesco, M., Anza, M., Civalleri, D., Di Tora, P., Capussotti, L., Morandi, G. B., Tirelli, C., Da Pian, P. P., Cortesi, E., Ruggeri, E., Fitzgerald, S. D., Davis, Faith, Bowen, Phyllis, Sutter, Eileen, Kikendall, Walter, McGannon, E., Brantley, P. A., Czyrko, C., Falardeau, C., Trepashko, Don, Skosey, John, Michelassi, F., Staniunas, R. J., Vignati, P. V., Beck, D. E., Karulf, R., Roettger, R., Braidt, J., Ruoff, K., Ackroyd, F., Shellito, P., Goh, H. S., Lin, L. W., Edwards, E., Farmer, J., Walters, C. A., Hyman, N. H., Hebert, J. C., Richman, Irving M., Staren, E. D., Sessions, S. C., Scoma, R. S., Clements, B., Smink, Jr., R. D., Arai, K., Sugita, A., Yamazaki, Y., Harada, H., Fukushima, T., Armstrong, D. N., Ballantyne, G. H., Sillin, L. F., Davie, R. J., Harding, L. K., Birch, N. J., Yamanouchi, T., Bayer, I., Mitmaker, B., Gordon, P. H., Wang, E., Kynaston, H., Edelstein, P. S., Thompson, S. M., Davies, R. J., Farmer, K. C. R., Oliver, S. E., Spigelman, A. D., Bennett, P., O'Kelly, T. J., Brading, A. F., Mortensen, N. J., Paul, P., McGannon, E. M., Huth, P., Hull-Boiner, S., Pezim, M. E., Johnson, H. W., Gillespie, K. D., Willard, P., Owen, D. A., Ramsey, P. S., Leu, S. Y., Hsu, H., Al-Humadi, Adil H., Eisman, E., Tries, J., Gupta, N. C., Frick, M. P., Boman, B. M., Franceschi, D., Eckhauser, M. L., Pritchard, T., Konsten, J., Baeten, C. G. M. I., Havenith, M. G., Soeters, P. B., Lau, P. W. K., Lorentz, T. G., Wong, J., and The III In-CYT-103 Immunoscintigraphy Study Group
- Published
- 1992
- Full Text
- View/download PDF
9. A suboptimal algorithm for synthesis of a movable object control
- Author
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Diyachuk, A K, primary, Orkin, B D, additional, and Orkin, S D, additional
- Published
- 2020
- Full Text
- View/download PDF
10. Podium presentations
- Author
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Foley, E. F., Marcello, P. W., Roberts, P. L., Murray, J. J., Coller, J. A., Veidenheimer, M. C., Schoetz, D. J., McIntyre, P. B., Pemberton, J. H., Wolff, B. G., Beart, Jr., R. W., Kelly, K. A., Dozois, R. R., Sugita, A., Fukushima, T., Harada, H., Yamamoto, M., Shimada, H., Tjandra, J. J., Fazio, V. W., Milson, J. W., Lavery, I. C., Oakley, J. R., Fabre, J. M., Karch, L. A., Bauer, J. J., Gorfine, S. R., Gelernt, I. M., Metcalf, A. M., Varilek, G., Keck, J. O., Hoffmann, D. C., Sgambati, S. A., Sardella, W. V., Marts, B. C., Longo, W. E., Vernava, III, A. M., Kennedy, D. J., Daniel, G. L., Jones, I., Venkatesh, K. S., Diamond, L. W., Larson, D. M., Ramanujam, P. J., Hicks, J. R., Ellis, C. N., Blakemore, W. S., Nathanson, S. D., Linden, M. D., Tender, P., Zarbo, R. J., Nelson, L., Bannon, J., Marks, G., Zhou, J., Mohiuddin, M., Marks, J., Pollard, C. W., Nivatvongs, S., Rojanasakul, A., Ilstrup, D. M., Speziale, N. J., Saclarides, T. J., Rubin, D. B., Szeluga, D. J., Morgado, P. J., Gomez, L. G., Morgado, Jr., P. J., Neto, J. A. Reis, Quilici, F. A., Cordeiro, F., Reis, Jr., J. A., Nitecki, S., Benn, P., Sarr, M. G., Weiland, L. H., Elhadad, A., Rouffet, F., Baillet, P., Akasu, T., Moriya, Y., Hojo, K., Sugihara, K., Oshima, H., Liu, S. K., Church, J. M., Kirkpatrick, J. R., Danielson, C. L., Dominguez, J. M., Jakate, S. M., Savin, M. H., Altringer, W. J., Lee, C. S., Spencer, M. P., Madoff, R. D., Barrett, R. C., Oster, M. A., Durdey, P., Stein, B. L., Staniunas, R. J., Grewal, H., Guillem, J. G., Quan, S., Enker, W. E., Cohen, A. M., van Tets, W. F., Kuijpers, H. C., Kerner, B. A., Wise, Jr., W. E., Golub, R. W., Arnold, M. W., Aguilar, P. S., Pernikoff, B. J., Eisenstat, T. E., Rubin, R. J., Oliver, G. C., Salvati, E. P., Lunniss, P. J., Sultan, A. H., Barker, P. G., Armstrong, P., Bartram, C. I., Phillips, R. K. S., Schouten, W. R., Briel, J. W., Auwerda, J. J. A., Harnsberger, J. R., Robbins, P. L., Brabbee, G. W., Ryhammer, A. M., Bek, K. M., Hanberg-Sørensen, F., Laurberg, S., Hoff, S. D., Bailey, H. R., Butts, D. R., Max, E., Smith, K. W., Zamora, L. F., Skakun, G. B., Khanduja, K. S., Lee, H., Beart, R. W., Spencer, R., Wiseman, J. S., Senagore, A. J., Bain, I. M., Oliff, J., Min, L., Neoptolomos, J., Keighley, M. R. B., O'Kelly, T. J., Davies, J., Brading, A. F., Mortensen, N. J. McC, Park, J. -G., Han, H. J., Kang, M. S., Nakamura, Y., Goldberg, G. S., Orkin, B. A., Smith, L. E., Fleshner, P. R., Freilich, M. I., Meagher, A. P., Adams, W. J., Lubowski, D. Z., King, D. W., Moran, M., Opelka, F., Timmcke, A., Hicks, T., Gathright, Jr., J. B., Leu, S. Y., Hsu, H., Dean, P. A., Ramsey, P. S., Nelson, H., Philpott, G., Siegel, B., Schwarz, S., Fleshman, J., Welch, M., Connett, J., Buie, W. D., Johnson, D. R., Heine, J. A., Wong, W. D., Rothenberger, D. A., Goldberg, S. M., Shafik, A., MacDonald, A., Craig, J. W., Finlay, I. G., Baxter, J. N., Muir, T. C., Parikh, S., Gold, R. P., Gottesman, L., Annibali, R., Öresland, T., Hallgren, T., Fasth, S., Hultén, L., Farouk, R., Duthie, G. S., MacGregor, A. B., Bartolo, D. C. C., Williamson, M. E. R., Lewis, W. G., Holdsworth, P. J., Hall, N., Finan, P. J., Johnston, D., Seow-Choen, F., Goh, H. S., Motson, R. W., Walsh, C. J., Mooney, E., Yamashita, H. J., Wise, W. E., Hartmann, R. F., Seccia, M., Menconi, C., Ghiselli, G., Cavina, E., Salomon, M. C., Ferrara, A., Larach, S. W., Williamson, P. R., Bass, E. M., Orsay, C. P., Firfer, B., Ramakrishnan, V., Abcarian, H., Bufo, A. J., Feldman, S., Daniels, G. A., Lieberman, R. C., Loder, P. B., Kamm, M. A., Nicholls, R. J., Kum, C. K., Ngoi, S. S., Goh, P. M. Y., Tekant, Y., Isaac, J. R., Gerstle, J. T., Kauffman, G. L., and Koltun, W. A.
- Published
- 1993
- Full Text
- View/download PDF
11. Poster Presentations
- Author
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Mitra, A., Walker, S. A., Bayer, I., Pickovsky, B., Cohen, S. M., Schmitt, S. L., Lucas, F. L., Wexner, S. D., Szilagy, E. J., Ryan, J. B., Williams, J. G., Deen, K. I., Grant, E., Kumar, D., Wiltz, O. H., Garcia, J. E., Feliciano, R., Martino, J., Solomon, M., McLeod, R. S., O'Connor, B., Steinhart, H., Greenberg, G., Cohen, Z., Meagher, A. P., Adams, W. J., Lubowski, D. Z., Ellis, C. N., Boggs, H. W., Coyle, D. J., Blakemore, W. S., Nahas, S. C., Ibrahim, R. El, Pinotti, H. W., Palakanis, K., DeNobile, J., Sweeney, B., Blankenship, C., Sun, J. H., Stiegmann, G. V., Kim, J. G., Pearlman, N. W., Landes, R. V., Hankin, R. C., Barkel, D. C., Beauregard, W. L., Poulik, M. D., Chen, J. C., Dmuchowski, C., Cho, E., Lee, P. Y., Fletcher, W. S., Sullivan, E. S., Vetto, J. T., Hull, T. L., Lavery, I. C., Saxton, J. P., McCue, J., Sheffield, J., Phillips, R., DiPierro, J., Milsom, J. W., Fazio, V. W., Strong, S. A., Vernava, III, A. M., Longo, W. E., Wade, T. P., Virgo, K. S., Coplin, M. A., Johnson, F. E., Cavina, E., Menconi, C., Ghiselli, G., Seccia, M., Tjandra, J. J., Lowndes, R., McKirdy, H., Schroeder, T., Hughes, L. E., Sentovich, S. M., Rivela, L. J., Thorson, A. G., Blatchford, G. J., Christensen, M. A., Jensen, L. L., Lowry, A. C., Miller, R., Mills, A., Durdey, P., Hock-Saive, D., Lombard, R., Jehaes, C., Markiewicz, S., Penders, L., Fontaine, F., Cusumano, P., Nelissen, G., MacDonald, A., Baxter, J. N., Bessent, R. G., Gray, H. W., Finlay, I. G., Duthie, G. S., Farouk, R., Bartolo, D. C. C., Ramanujam, P. S., Venkatesh, K. S., Oliver, G. C., Vachon, D., Eisenstat, T. E., Rubin, R. J., Salvati, E. P., Dorsey-Tyler, K. R., Harmon, G., Medwell, S. J., Binderow, S. R., Noguerás, J. J., Jagelman, D. G., Decanini, C., Bohm, B., Stolfi, V. W., Cataldo, P. A., Hadick, C., Resnikov, P., Mellinger, J. D., Cunningham, B., Vayer, Jr., A. J., Larach, S. W., Williamson, P. R., Ferrara, A., Salomon, M., Nogueras, J. J., Sullivan, J., Staniunas, R. J., Keck, J. O., Counihan, T., Marcello, P., Barrett, R. C., Oster, M., Roberts, P. L., Schoetz, D. J., Murray, J. J., Veidenheimer, M. C., Coller, J. A., Sagar, P. M., Lewis, W., Williamson, M., Holdsworth, P. J., Johnston, D., Jorge, J. M. N., Morgado, Jr., P. J., James, K., Morgado, Jr., P., Penna, C., Kartheuser, A., Tiret, E., Parc, R., McIntyre, P. B., Pemberton, J. H., Wolff, B. G., Dozois, R. R., Beart, R. W., Kelley, K. A., Harrison, J. B., Hockenberry, S. E., Williamson, M. E. R., Lewis, W. G., Sagar, P., Armstrong, D. N., Collopy, B. C., Ryan, P. J., Fink, R., Mackay, J. R., Woods, R. J., Nazarian, H. K., Kong, L. B., Fleshner, P. R., Keighley, M. R. B., Farmakis, N., Tudor, R., Wiltz, O., Wong, W. D., Goldberg, S. M., Rothenberger, D. A., Arnold, M. W., Schneebaum, S., Martin, Jr., E. W., Young, D. C., Schechter, S., Snyder, M. L., Orkin, B. A., Smith, L. E., Dean, P. A., Ramsey, P. S., Nelson, H., Barker, G., Neoptolomos, J. P., Patel, R. T., Pall, A., and Adu, D.
- Published
- 1993
- Full Text
- View/download PDF
12. Carbon dioxide embolism associated with transanal total mesorectal excision surgery: A report from the international registries
- Author
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Dickson, E. A., Penna, M., Cunningham, C., Ratcliffe, F. M., Chantler, J., Crabtree, N. A., Tuynman, J. B., Albert, M. R., Monson, J. R. T., Hompes, R., Abdelmoaty, W., Adamina, M., Aigner, F., Alavi, K., Albers, B., Al Furajii, H., Allison, A., Eduardo, S., Araujo, A., Apostolides, G. Y., Arezzo, A., Arnold, S. J., Aryal, K., Ashamalla, S., Ashraf, Sana, Attaluri, V., Austin, R., Barugo-La, G., Beggs, A., Belgers, H. J., Bell, S., Bemelman, W., Berti, S., Biebl, M., Blondeel, J., Binky, B., Baloyiannis, I. -N., Bandyopadhyay, D., Boni, L., Bordeianou, L., Box, B., Boyce, S., Brokelman, W., Brown, C. J., Bruegger, L., Buchli, C., Christian Buchs, N., Bulut, O., Burt, C., Bursics, A., Cahill, R. A., Pablo Campana, J., Caricato, M., Caro-Tar-Rago, A., Casans, F., Cassinotti, E., Caycedo-Marulan-Da, A., Chadi, S. A., Chandrasinghe, P., Chaudhri, S., Chaumont, N., Chitsabesan, P., Coget, J., Collera, P., Coleman, M., Courtney, E. D., Dagbert, F., Dalton, S. J., Daniel, G., Clark, D. A., De-Drye, L., De La Torre, J., Dapri, G., Dayal, S. P., De Chaisemartin, C., Borja De Lacy, F., Blasco Delgado, O., Di Candido, F., Diaz Del Gobbo, G., De Graaf, E. J. R., Delrio, P., De Pooter, K., D'Hooge, P., Doornebosch, P., Duff, S., Du Jardin, P., Dzhumabaev, K. E., Tom Edwards, M., Egenvall, I., Espin, E., Eugenio, M., Egenvall, M. -I., Ravn Eriksen, J., Faerden, A. E., Faes, S., Simo Fernandez, V., Fichera, A., Fierens, J., Fierens, K., Forgan, T., Francis, N., Francombe, J., Francone, E., Francone, T., Gamage, B., Perez Garcia, J. A., Ethem Gecim, I., Van Geluwe, B., Gin-Gert, C., George, V., Gloeckler, M., Gogenur, I., Goulart, A., Grolich, T., Haas, E., Hameed, U., Hahnloser, D., Harikrishnan, A., Harris, G., Haunold, I., Hendrickse, C., Hendrickx, T., Heyns, M., Horwood, J., Huerga, D., Ito, M., Jarimba, A., Joeng, H. K. M., Jones, O., Jutten, G., Kala, Z., Kita, Y., Knol, J., Thengugal Kochupapy, R., Kneist, W., Kok, A. S. Y., Kusters, M., Lacy, A. M., Laka-Tos, M., Lal, R., Lakkis, Z., Leao, P., Lambrechts, A., Lee, L., Lelong, B., Leung, E., Lezoche, E., Sender Liberman, A., Lidder, P., An-Drade Lima, M., Loganathan, A., Lombana, L. J., Lorenzon, Laura, Loriz, H., Lukas, M., Lutrin, D., Mackey, P., Mamedli, Z. Z., Mansfield, S., Marcello, P., Marcoen, S., Romero Marcos, J. M., Marcy, T., Marecik, S., Marks, J., Marsanic, P., Mattacheo, A., Maun, D., May, D., Maykel, J. A., Mcarthur, D., Mccallum, I., Mccarthy, K., Mclemore, E. C., Ramon Sil-Viera Mendes, C., Messaris, E., Michalopoulos, A., Mikalauskas, S., Miles, A., Millan, M., Mills, S., Miskovic, D., Montroni, I., Moore, E., Moore, T., Mori, Simona, Morino, M., Muratore, A., Mutafchiyski, V., Myers, A., Van Nieuwenhove, Y., Nishizawa, Y., Ng, P., John Nolan, G., Obias, V., Ochsner, A., Hwan Oh, J., Onghena, T., Oommen, S., Orkin, B. A., Osman, K., Ouro, S., Panis, Y., Papavramidis, T., Von Papen, M., Papp, G., Paquette, I., Paraoan, M. T., Paredes, J. P., Pastor, C., Pattyn, P. R. L., Karim Perdawood, S., Wan Pei, C. F., Piehslinger, J., Penchev, D., Oliva Perez, R., Persiani, Roberto, Pfeffer, F., Terry Phang, P., Pokela, V., Picchetto, A., Poskus, E., Prieto, D., Que-Reshy, F. A., Ramcharan, S., Rauch, S., Rega, D., Reyes, J. C., Ris, F., Delgado Rivilla, S., Alexander Rockall, T., Roquete, P., Rossi, G., Ruffo, G., Sakai, Y. -S., Sands, D., Sao Juliao, G. P., Scala, Alessandro, Scala, D., Estevez Schwarz, L., Edmond Seid, V., Seitinger, G., Shaikh, I. A., Sharma, A., Siet-Ses, C., Singh, B., Helmer Sjo, O., Kyung Sohn, D., Sora-Via, C., Sosef, M. N., Spinelli, A., Speakman, C., Steele, S., Stephan, V., Stevenson, A. R. L., Stotland, P., Studer, P., Strypstein, S., Sylla, P., Szyszkowitz, A., Talwar, A., Tanis, P., Tejedor, P., Pastor Teso, E., Tognelli, J., Torkington, J., Tschann, P., Tuech, J. -J., Tuerler, A., Tzovaras, G., Ugolini, G., Vallribera, F., Vansteenkiste, F., Vangenechten, E., Verdaasdonk, E. G. G., Vilela, N., Walter, B., Warren, O. J., Visser, T., Warrier, S., Warner, M., Waru-Savitarne, J., Whiteford, M. H., Andreas Wik, T., Witzig, J. -A., Wolff, T., Wolthuis, A. M., Wynn, G., Ashraf S., Lorenzon L. (ORCID:0000-0001-6736-0383), Mori S., Persiani R. (ORCID:0000-0002-1537-5097), Scala A., Dickson, E. A., Penna, M., Cunningham, C., Ratcliffe, F. M., Chantler, J., Crabtree, N. A., Tuynman, J. B., Albert, M. R., Monson, J. R. T., Hompes, R., Abdelmoaty, W., Adamina, M., Aigner, F., Alavi, K., Albers, B., Al Furajii, H., Allison, A., Eduardo, S., Araujo, A., Apostolides, G. Y., Arezzo, A., Arnold, S. J., Aryal, K., Ashamalla, S., Ashraf, Sana, Attaluri, V., Austin, R., Barugo-La, G., Beggs, A., Belgers, H. J., Bell, S., Bemelman, W., Berti, S., Biebl, M., Blondeel, J., Binky, B., Baloyiannis, I. -N., Bandyopadhyay, D., Boni, L., Bordeianou, L., Box, B., Boyce, S., Brokelman, W., Brown, C. J., Bruegger, L., Buchli, C., Christian Buchs, N., Bulut, O., Burt, C., Bursics, A., Cahill, R. A., Pablo Campana, J., Caricato, M., Caro-Tar-Rago, A., Casans, F., Cassinotti, E., Caycedo-Marulan-Da, A., Chadi, S. A., Chandrasinghe, P., Chaudhri, S., Chaumont, N., Chitsabesan, P., Coget, J., Collera, P., Coleman, M., Courtney, E. D., Dagbert, F., Dalton, S. J., Daniel, G., Clark, D. A., De-Drye, L., De La Torre, J., Dapri, G., Dayal, S. P., De Chaisemartin, C., Borja De Lacy, F., Blasco Delgado, O., Di Candido, F., Diaz Del Gobbo, G., De Graaf, E. J. R., Delrio, P., De Pooter, K., D'Hooge, P., Doornebosch, P., Duff, S., Du Jardin, P., Dzhumabaev, K. E., Tom Edwards, M., Egenvall, I., Espin, E., Eugenio, M., Egenvall, M. -I., Ravn Eriksen, J., Faerden, A. E., Faes, S., Simo Fernandez, V., Fichera, A., Fierens, J., Fierens, K., Forgan, T., Francis, N., Francombe, J., Francone, E., Francone, T., Gamage, B., Perez Garcia, J. A., Ethem Gecim, I., Van Geluwe, B., Gin-Gert, C., George, V., Gloeckler, M., Gogenur, I., Goulart, A., Grolich, T., Haas, E., Hameed, U., Hahnloser, D., Harikrishnan, A., Harris, G., Haunold, I., Hendrickse, C., Hendrickx, T., Heyns, M., Horwood, J., Huerga, D., Ito, M., Jarimba, A., Joeng, H. K. M., Jones, O., Jutten, G., Kala, Z., Kita, Y., Knol, J., Thengugal Kochupapy, R., Kneist, W., Kok, A. S. Y., Kusters, M., Lacy, A. M., Laka-Tos, M., Lal, R., Lakkis, Z., Leao, P., Lambrechts, A., Lee, L., Lelong, B., Leung, E., Lezoche, E., Sender Liberman, A., Lidder, P., An-Drade Lima, M., Loganathan, A., Lombana, L. J., Lorenzon, Laura, Loriz, H., Lukas, M., Lutrin, D., Mackey, P., Mamedli, Z. Z., Mansfield, S., Marcello, P., Marcoen, S., Romero Marcos, J. M., Marcy, T., Marecik, S., Marks, J., Marsanic, P., Mattacheo, A., Maun, D., May, D., Maykel, J. A., Mcarthur, D., Mccallum, I., Mccarthy, K., Mclemore, E. C., Ramon Sil-Viera Mendes, C., Messaris, E., Michalopoulos, A., Mikalauskas, S., Miles, A., Millan, M., Mills, S., Miskovic, D., Montroni, I., Moore, E., Moore, T., Mori, Simona, Morino, M., Muratore, A., Mutafchiyski, V., Myers, A., Van Nieuwenhove, Y., Nishizawa, Y., Ng, P., John Nolan, G., Obias, V., Ochsner, A., Hwan Oh, J., Onghena, T., Oommen, S., Orkin, B. A., Osman, K., Ouro, S., Panis, Y., Papavramidis, T., Von Papen, M., Papp, G., Paquette, I., Paraoan, M. T., Paredes, J. P., Pastor, C., Pattyn, P. R. L., Karim Perdawood, S., Wan Pei, C. F., Piehslinger, J., Penchev, D., Oliva Perez, R., Persiani, Roberto, Pfeffer, F., Terry Phang, P., Pokela, V., Picchetto, A., Poskus, E., Prieto, D., Que-Reshy, F. A., Ramcharan, S., Rauch, S., Rega, D., Reyes, J. C., Ris, F., Delgado Rivilla, S., Alexander Rockall, T., Roquete, P., Rossi, G., Ruffo, G., Sakai, Y. -S., Sands, D., Sao Juliao, G. P., Scala, Alessandro, Scala, D., Estevez Schwarz, L., Edmond Seid, V., Seitinger, G., Shaikh, I. A., Sharma, A., Siet-Ses, C., Singh, B., Helmer Sjo, O., Kyung Sohn, D., Sora-Via, C., Sosef, M. N., Spinelli, A., Speakman, C., Steele, S., Stephan, V., Stevenson, A. R. L., Stotland, P., Studer, P., Strypstein, S., Sylla, P., Szyszkowitz, A., Talwar, A., Tanis, P., Tejedor, P., Pastor Teso, E., Tognelli, J., Torkington, J., Tschann, P., Tuech, J. -J., Tuerler, A., Tzovaras, G., Ugolini, G., Vallribera, F., Vansteenkiste, F., Vangenechten, E., Verdaasdonk, E. G. G., Vilela, N., Walter, B., Warren, O. J., Visser, T., Warrier, S., Warner, M., Waru-Savitarne, J., Whiteford, M. H., Andreas Wik, T., Witzig, J. -A., Wolff, T., Wolthuis, A. M., Wynn, G., Ashraf S., Lorenzon L. (ORCID:0000-0001-6736-0383), Mori S., Persiani R. (ORCID:0000-0002-1537-5097), and Scala A.
- Abstract
BACKGROUND: Carbon dioxide embolus has been reported as a rare but clinically important risk associated with transanal total mesorectal excision surgery. To date, there exists limited data describing the incidence, risk factors, and management of carbon dioxide embolus in transanal total mesorectal excision. OBJECTIVE: This study aimed to obtain data from the transanal total mesorectal excision registries to identify trends and potential risk factors for carbon dioxide embolus specific to this surgical technique. DESIGN: Contributors to both the LOREC and OSTRiCh transanal total mesorectal excision registries were invited to report their incidence of carbon dioxide embolus. Case report forms were collected detailing the patient-specific and technical factors of each event. SETTINGS: The study was conducted at the collaborating centers from the international transanal total mesorectal excision registries. MAIN OUTCOME MEASURES: Characteristics and outcomes of patients with carbon dioxide embolus associated with transanal mesorectal excision were measured. RESULTS: Twenty-five cases were reported. The incidence of carbon dioxide embolus during transanal total mesorectal excision is estimated to be ≈0.4% (25/6375 cases). A fall in end tidal carbon dioxide was noted as the initial feature in 22 cases, with 13 (52%) developing signs of hemodynamic compromise. All of the events occurred in the transanal component of dissection, with mean (range) insufflation pressures of 15 mm Hg (12-20 mm Hg). Patients were predominantly (68%) in a Trendelenburg position, between 30° and 45°. Venous bleeding was reported in 20 cases at the time of carbon dioxide embolus, with periprostatic veins documented as the most common site (40%). After carbon dioxide embolus, 84% of cases were completed after hemodynamic stabilization. Two patients required cardiopulmonary resuscitation because of cardiovascular collapse. There were no deaths. LIMITATIONS: This is a retrospective study surveying r
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- 2019
13. Perineal manifestations of HIV infection
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Orkin, B. A. and Smith, L. E.
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- 1992
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14. 1992 Scientific Session of the Society of American Gastrointestinal Surgeons (SAGES) Washington, D.C., USA, April 11–12, 1992
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Salky, Barry, Bauer, Joel, Easter, D. W., Cuschieri, A., Lavelle-Jones, M., Nathanson, L., Brandt, C. P., Priebe, P. P., Eckhauser, M. L., Henriques, III, Horace F., Deziel, Daniel J., Millikan, Keith W., Staren, Edgar D., Economou, Steven G., Lexer, G. W., Lexer, G. Ch., Lehofer, F., Meiser, G., Boeckl, O., Williams, Mark D., Murr, Peter C., Shimomura, Kazuyuki, Ohtomo, Yumiko, Ishizaki, Yoichi, Noie, Tamaki, Abe, Hideki, Nayeem, Sarder Abdun, Bandai, Yasutsugu, Idezuki, Yasuo, Kam, David, Scheeres, David, Nagai, Hideo, Kondo, Yasuo, Yasuda, Toshihiko, Kasahara, Kogoro, Kanazawa, Kyotaro, Wittgen, C. M., Andrus, J. P., Andrus, C. H., Kaminski, D. L., Fried, G. M., Sigman, H. H., Meakins, J. L., Hinchey, E. J., Garzon, J., Barkun, J. S., Mamazza, J., Wexler, M. J., Bordelon, B. M., Hobday, K. A., Hunter, J. G., Saunders, C. J., Gardiner, B., Leary, B. F., F. N. P., Frey, C. F., Wolfe, B. M., Kozarek, R. A., Traverso, L. W., Ball, T. J., Brandabur, J., Jolly, P. C., Patterson, D. J., Ryan, J. A., Thirlby, R. C., Wechter, D. G., Hunter, J. A., Fletcher, D. P., Molnar, Robert G., Apelgren, Keith N., Kisala, John M., Way, Lawrence W., Wetter, Albert, Pietrafitta, Joseph J., Schultz, Leonard S., Graber, John N., Hickok, David F., Congreve, D., Zinnecker, H., Lohmuller, J., Legrand, M., Detroz, B., Honore, P., Jacquet, N., Yamamoto, M., Stiegmann, G., Durham, J., Berguer, R., Fujiyama, Y., Oba, Y., Downey, J., Miho, O., Green, P., Satava, R., Hill, J., Simon, I., Brodish, R. J., Soper, Nathaniel J., Dunnegan, Deanna L., Peters, Jeffrey H., Innes, Jeffrey T., Front, Mary E., Ellison, E. Christopher, Swanstrom, Lee, Sangster, William, Stoker, Mark E., Phillips, E., Carroll, B., Fallas, M., Daykhovsky, L., Murphy, B., Miller, S., Keiter, N., Halpern, Norman B., Escudero-Fabre, Angel, Sack, Jonathan, Himal, H. S., Luchette F., Doerr R., Kulaylat M., Stephan R., Kelly K., Fowler, Dennis L., White, Sharon A., Church, James M., De Paula, A. L., Hashiba, K., Ambroze, Jr, W. L., Nezhat, C., Nezhat, F., Orangio, G., Brooks, D. C., Becker, J. M., Connors, P. J., Carr-Locke, D. L., Adams, D. B., Borowicz, M. R., Wootton, III, F. T., Cunningham, J. T., Cirocco, W. C., Rusin, L. C., Franceschi, Dido, Pritchard, Timothy, Eckhauser, Marc, Estes, J. M., Szabo, Z., Harrison, M. R., Krishnan, S. M., Goh, P. M. Y., Ambroze, Jr., W. L., Orangio, G. R., Tucker, J. G., Baird, D., Herndon, M., Lucas, G. W., Bell, R. C. W., Stiegmann, G. V., Sun, J., Kim, J., Lucia, M. S., Bender, J. S., Talamini, M. A., Bessler, Marc, Treat, Michael R., Canady, J., Nicolo, E., Jagdeo, C., McQueen, J., Fontana, F., Dewitty, R., Castellano, M., Elmann, E. M., Lobbato, V. J., Cosgrove, John M., Franklin, Howard, Margolis, Irving B., de la Torre, R., Donahue, PE, Schlesinger, P., Sluss, K., Attar, B., Nyhus, L. M., Anan, K., Fletcher, D. R., Flowers, J. L., Zucker, K. A., Graham, S. M., Scovill, W. A., Imbembo, A. L., Bailey, R. W., Gagner, M., Rheault, M., Dubuc, J., Ghobrial, Rafik, MacFadyen, Jr., Bruce V., Catalano, Mark, Raijman, Isaac, Haicken, Barry N., Daijo, Hashimoto, Shuji, Kajiwara, Takanobu, Hoshino, Fukuyo, Tsuneo, Kitano, S., Moriyama, M., Sugimachi, K., Kudo, Shin-ei, Kusaka, Takashi, Nakajima, Kouji, Kimata, Hiroyuki, Miura, Kouji, Takano, Yukio, Lamphier, Jonathan B., Diflo, Thomas, Kondi, Edward S., Larson, G. M., Vitale, G. C., Voight, W., Cheadle, W., Miller, F., Leahy, P. F., Pennino, R. P., Furman, R. H., Libutti, Steven K., Williams, Mathew R., Litwin, D., Johnson, D., Osachoff, J., Gallagher, C., Church, D., Mansour, M. A., Martin, Matt B., Abrams, Arkin, Ballen, Blievernicht, Bowman, Davis, Farley, Hoxworth, Ingram, Leone, Lindsey, Newman, Price, Streck, Weatherly, Young, Miscusi, Route G., Masoni, L., Gasparrini, M., Montori, A., Montori, A., Munakata, Y., Kawasaki, S., Hashikura, Y., Hashimoto, S., Hayashi, K., Numata, M., Makuuchi, M., Mustafa, I. A., Reed, W. P., Coe, N. P. W., Leigh H., Nadler, Nelson, M. T., Nakashima, M., Mulvihill, S. J., Olsen, Douglas O., Corbitt, John D., Edleman, David S., Unger, Stephen, Unger, Harold, Orkin, B. A., Smith, L. E., Paz-Partlow, M., Berci, G., Sackier, J. M., Miller, John, Kieth E., Nichols, Ollila, David, Gibbons, Gregory E., Davanzo, Mark A., Polacek, Michael A., Pons, R., Grannan, K., Welling, R., Pritchard, Timothy J., Richards, William O., Unger, S. W., Rosenbaum, G., Unger, H. M., Edelman, D. S., Schirmer, B. D., Dix, J., Schmieg, Jr., R. E., Aguilar, M., Schirmer, B. D., Dix, J., Scott, T. R., Zucker, K. A., Bailey, R. W., Bergstein, J. M., Seone, D., Wittmann, D. H., Quebbeman, E. J., Aprahamian, C., McGrath, Michael, Shapiro, Stephen, Gordon, Leo, Adashek, Kenneth, Daykhovsky, Leon, Shoop, Stephen A., Sackier, Jonathan, Meakin, J. L., Snyder, Samuel K., Symmonds, Richard E., Roberts, John W., Hendricks, John C., Smith, Randall W., Frazee, Richard C., Soper, Nathaniel J., Brunt, L. Michael, Fleshman, James, Meininger, Thomas A., Dunnegan, Deanna L., RN, Sudan, Debra, Mellinger, John, Miller, Sidney, Sugawa, C., Lucas, C. E., Szabo, Zoltan, Berci, George, Hunter, John G., Unger, S. W., Unger, H. M., Edelman, D. S., Weaver, Donald W., Bouwman, David, Tyburski, James, and Wierson, T. A.
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- 1992
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15. SYSTEMIC SEXTANT BIOPSIES UNDER TRANSRECTAL ULTRASOUND - IS IT STILL INDICATED IN ALL CASES OF ELEVATED PSA?
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Abu Arafeh, W., Zilberman, M., Orkin, B., Hadas, I., and Farkas, A.
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- 1997
16. International preoperative rectal cancer management: staging, neoadjuvant treatment, and impact of multidisciplinary teams
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Augestad KM, Lindsetmo RO, Stulberg J, Reynolds H, Senagore A, Champagne B, Heriot AG, Leblanc F, Delaney CP, Ambrosetti P, Andujar J, Baixuli J, Balen E, Baxter N, Beck D, Bemelman W, Bergamaschi R, Billingham R, Birch D, Bonardi R, Bonardi M, Bonjer J, Braga M, Buch H, Buechler M, Burnstein M, Campbell K, Caushaj P, Celebrezze J, Chang G, Cheong D, Cohen J, Colak T, Delaney C, Dhoore A, Douglas P, Dozois E, Efron J, Ellis N, Enker W, Fanelli RD, Fazio V, Fleshman J, Franklin M, Fry R, Garcia Aguilar J, Garcia Granero E, Habr Gama A, Hahnloser D, Harris G, Hasegawa H, Holm T, Horgan P, Hyman N, Irwin T, Joh YG, Jongen J, Kaiser A, Kang SB, Kariv Y, Kennedy R, Kessler H, Khan M, Kim SH, Krokowicz P, Kwok S, Lacy A, Larson D, Law WL, Lee E, Lippert H, Ludwig K, Lynch AC, MacRae H, Madbouly K, Maeda K, Marderstein E, Marino M, Marks J, Maurer C, McLeod R, Monson J, Mortensen N, Neary P, Newstead G, OBrien D, Orangio G, Orkin B, Page M, Påhlman L, Panis Y, Panton N, Pennickx F, Phang T, Pinedo Mancilla G, Post S, Rafferty J, Rajput A, Reis Neto dos JA, Rivadeneira D, Roselli J, Rosen H, Rossi G, Rouanet P, Rullier E, Schiedeck T, Schiessel R, Schlachta C, Schwenk W, Seow Choen F, Sim R, Sing WK, Stamos M, Sternberg J, Tuckson W, Vaccaro C, Vargas D, Vignali A, Vonen B, Weiss E, Wexner S, Whiteford M, Wibe A, Williams N, Woods R, Yamamoto T, Young Fadok T., UGOLINI, GIAMPAOLO, Augestad KM, Lindsetmo RO, Stulberg J, Reynolds H, Senagore A, Champagne B, Heriot AG, Leblanc F, Delaney CP, Ambrosetti P, Andujar J, Baixuli J, Balen E, Baxter N, Beck D, Bemelman W, Bergamaschi R, Billingham R, Birch D, Bonardi R, Bonardi M, Bonjer J, Braga M, Buch H, Buechler M, Burnstein M, Campbell K, Caushaj P, Celebrezze J, Chang G, Cheong D, Cohen J, Colak T, Delaney C, Dhoore A, Douglas P, Dozois E, Efron J, Ellis N, Enker W, Fanelli RD, Fazio V, Fleshman J, Franklin M, Fry R, Garcia-Aguilar J, Garcia-Granero E, Habr-Gama A, Hahnloser D, Harris G, Hasegawa H, Holm T, Horgan P, Hyman N, Irwin T, Joh YG, Jongen J, Kaiser A, Kang SB, Kariv Y, Kennedy R, Kessler H, Khan M, Kim SH, Krokowicz P, Kwok S, Lacy A, Larson D, Law WL, Lee E, Lippert H, Ludwig K, Lynch AC, MacRae H, Madbouly K, Maeda K, Marderstein E, Marino M, Marks J, Maurer C, McLeod R, Monson J, Mortensen N, Neary P, Newstead G, OBrien D, Orangio G, Orkin B, Page M, Påhlman L, Panis Y, Panton N, Pennickx F, Phang T, Pinedo Mancilla G, Post S, Rafferty J, Rajput A, Reis Neto dos JA, Rivadeneira D, Roselli J, Rosen H, Rossi G, Rouanet P, Rullier E, Schiedeck T, Schiessel R, Schlachta C, Schwenk W, Seow-Choen F, Sim R, Sing WK, Stamos M, Sternberg J, Tuckson W, Ugolini G, Vaccaro C, Vargas D, Vignali A, Vonen B, Weiss E, Wexner S, Whiteford M, Wibe A, Williams N, Woods R, Yamamoto T, Young-Fadok T., Augestad, K, Lindsetmo, R, Stulberg, J, Reynolds, H, Senagore, A, Champagne, B, Heriot, A, Leblanc, F, Delaney, C, Ambrosetti, P, Andujar, J, Baixuli, J, Balen, E, Baxter, N, Beck, D, Bemelman, W, Bergamaschi, R, Billingham, R, Birch, D, Bonardi, R, Bonardi, M, Bonjer, J, Braga, M, Buch, H, Buechler, M, Burnstein, M, Campbell, K, Caushaj, P, Celebrezze, J, Chang, G, Cheong, D, Cohen, J, Colak, T, Dhoore, A, Douglas, P, Dozois, E, Efron, J, Ellis, N, Enker, W, Fanelli, R, Fazio, V, Fleshman, J, Franklin, M, Fry, R, Garcia-Aguilar, J, Garcia-Granero, E, Habr-Gama, A, Hahnloser, D, Harris, G, Hasegawa, H, Holm, T, Horgan, P, Hyman, N, Irwin, T, Joh, Y, Jongen, J, Kaiser, A, Kang, S, Kariv, Y, Kennedy, R, Kessler, H, Khan, M, Kim, S, Krokowicz, P, Kwok, S, Lacy, A, Larson, D, Law, W, Lee, E, Lippert, H, Ludwig, K, Lynch, A, Macrae, H, Madbouly, K, Maeda, K, Marderstein, E, Marino, M, Marks, J, Maurer, C, Mcleod, R, Monson, J, Mortensen, N, Neary, P, Newstead, G, Obrien, D, Orangio, G, Orkin, B, Page, M, Pahlman, L, Panis, Y, Panton, N, Pennickx, F, Phang, T, Pinedo Mancilla, G, Post, S, Rafferty, J, Rajput, A, Reis Neto dos, J, Rivadeneira, D, Roselli, J, Rosen, H, Rossi, G, Rouanet, P, Rullier, E, Schiedeck, T, Schiessel, R, Schlachta, C, Schwenk, W, Seow-Choen, F, Sim, R, Sing, W, Stamos, M, Sternberg, J, Tuckson, W, Ugolini, G, Vaccaro, C, Vargas, D, Vignali, A, Vonen, B, Weiss, E, Wexner, S, Whiteford, M, Wibe, A, Williams, N, Woods, R, Yamamoto, T, and Young-Fadok, T
- Subjects
medicine.medical_specialty ,Internationality ,Colorectal cancer ,health care facilities, manpower, and services ,medicine.medical_treatment ,education ,Preoperative care ,Article ,RECTAL CANCER ,COLORECTAL SURGERY ,Preoperative Care ,MANAGEMENT ,Medicine ,Humans ,Stage (cooking) ,health care economics and organizations ,Neoadjuvant therapy ,Neoplasm Staging ,Patient Care Team ,Rectal Neoplasm ,medicine.diagnostic_test ,business.industry ,Rectal Neoplasms ,General surgery ,Cancer ,Rectal examination ,Vascular surgery ,medicine.disease ,humanities ,Neoadjuvant Therapy ,Surgery ,Treatment Outcome ,Health Care Survey ,Health Care Surveys ,Practice Guidelines as Topic ,MULTIDISCIPLINARY TEAMS ,Rectal Neoplasms - pathology - surgery - therapy ,business ,Human ,Abdominal surgery - Abstract
Law, WL is one of the members of the International Rectal Cancer Study Group, BACKGROUND: Little is known regarding variations in preoperative treatment and practice for rectal cancer (RC) on an international level, yet practice variation may result in differences in recurrence and survival rates. METHODS: One hundred seventy-three international colorectal centers were invited to participate in a survey of preoperative management of rectal cancer. RESULTS: One hundred twenty-three (71%) responded, with a majority of respondents from North America, Europe, and Asia. Ninety-three percent have more than 5 years' experience with rectal cancer surgery. Fifty-five percent use CT scan, 35% MRI, 29% ERUS, 12% digital rectal examination and 1% PET scan in all RC cases. Seventy-four percent consider threatened circumferential margin (CRM) an indication for neoadjuvant treatment. Ninety-two percent prefer 5-FU-based long-course neoadjuvant chemoradiation therapy (CRT). A significant difference in practice exists between the US and non-US surgeons: poor histological differentiation as an indication for CRT (25% vs. 7.0%, p = 0.008), CRT for stage II and III rectal cancer (92% vs. 43%, p = 0.0001), MRI for all RC patients (20% vs. 42%, p = 0.03), and ERUS for all RC patients (43% vs. 21%, p = 0.01). Multidisciplinary team meetings significantly influence decisions for MRI (RR = 3.62), neoadjuvant treatment (threatened CRM, RR = 5.67, stage II + III RR = 2.98), quality of pathology report (RR = 4.85), and sphincter-saving surgery (RR = 3.81). CONCLUSIONS: There was little consensus on staging, neoadjuvant treatment, and preoperative management of rectal cancer. Regular multidisciplinary team meetings influence decisions about neoadjuvant treatment and staging methods., published_or_final_version
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- 2010
17. A SIMULATION COMPLEX OF MANNED AND UNMANNED AERIAL VEHICLES JOINT WARFARE IN THE AIRCRAFT-CARRIER NAVAL GROUP DEFEAT OPERATION
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Diyachuk, А. К., primary, Nesterov, V. A., additional, Orkin, B. D., additional, Orkin, S. D., additional, Sypalo, K. I., additional, and Toporov, N. B., additional
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- 2017
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18. International preoperative rectal cancer management: staging, neoadjuvant treatment, and impact of multidisciplinary teams
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Augestad, K, Lindsetmo, R, Stulberg, J, Reynolds, H, Senagore, A, Champagne, B, Heriot, A, Leblanc, F, Delaney, C, Ambrosetti, P, Andujar, J, Baixuli, J, Balen, E, Baxter, N, Beck, D, Bemelman, W, Bergamaschi, R, Billingham, R, Birch, D, Bonardi, R, Bonardi, M, Bonjer, J, Braga, M, Buch, H, Buechler, M, Burnstein, M, Campbell, K, Caushaj, P, Celebrezze, J, Chang, G, Cheong, D, Cohen, J, Colak, T, Dhoore, A, Douglas, P, Dozois, E, Efron, J, Ellis, N, Enker, W, Fanelli, R, Fazio, V, Fleshman, J, Franklin, M, Fry, R, Garcia-Aguilar, J, Garcia-Granero, E, Habr-Gama, A, Hahnloser, D, Harris, G, Hasegawa, H, Holm, T, Horgan, P, Hyman, N, Irwin, T, Joh, Y, Jongen, J, Kaiser, A, Kang, S, Kariv, Y, Kennedy, R, Kessler, H, Khan, M, Kim, S, Krokowicz, P, Kwok, S, Lacy, A, Larson, D, Law, W, Lee, E, Lippert, H, Ludwig, K, Lynch, A, Macrae, H, Madbouly, K, Maeda, K, Marderstein, E, Marino, M, Marks, J, Maurer, C, Mcleod, R, Monson, J, Mortensen, N, Neary, P, Newstead, G, Obrien, D, Orangio, G, Orkin, B, Page, M, Pahlman, L, Panis, Y, Panton, N, Pennickx, F, Phang, T, Pinedo Mancilla, G, Post, S, Rafferty, J, Rajput, A, Reis Neto dos, J, Rivadeneira, D, Roselli, J, Rosen, H, Rossi, G, Rouanet, P, Rullier, E, Schiedeck, T, Schiessel, R, Schlachta, C, Schwenk, W, Seow-Choen, F, Sim, R, Sing, W, Stamos, M, Sternberg, J, Tuckson, W, Ugolini, G, Vaccaro, C, Vargas, D, Vignali, A, Vonen, B, Weiss, E, Wexner, S, Whiteford, M, Wibe, A, Williams, N, Woods, R, Yamamoto, T, Young-Fadok, T, Augestad K. M., Lindsetmo R. -O., Stulberg J., Reynolds H., Senagore A., Champagne B., Heriot A. G., Leblanc F., Delaney C. P., Ambrosetti P., Andujar J., Baixuli J., Balen E., Baxter N., Beck D., Bemelman W., Bergamaschi R., Billingham R., Birch D., Bonardi R., Bonardi M., Bonjer J., Braga M., Buch H., Buechler M., Burnstein M., Campbell K., Caushaj P., Celebrezze J., Chang G., Cheong D., Cohen J., Colak T., Dhoore A., Douglas P., Dozois E., Efron J., Ellis N., Enker W., Fanelli R. D., Fazio V., Fleshman J., Franklin M., Fry R., Garcia-Aguilar J., Garcia-Granero E., Habr-Gama A., Hahnloser D., Harris G., Hasegawa H., Holm T., Horgan P., Hyman N., Irwin T., Joh Y. G., Jongen J., Kaiser A., Kang S. B., Kariv Y., Kennedy R., Kessler H., Khan M., Kim S. H., Krokowicz P., Kwok S., Lacy A., Larson D., Law W. L., Lee E., Lippert H., Ludwig K., Lynch A. C., MacRae H., Madbouly K., Maeda K., Marderstein E., Marino M., Marks J., Maurer C., McLeod R., Monson J., Mortensen N., Neary P., Newstead G., OBrien D., Orangio G., Orkin B., Page M., Pahlman L., Panis Y., Panton N., Pennickx F., Phang T., Pinedo Mancilla G., Post S., Rafferty J., Rajput A., Reis Neto dos J. A., Rivadeneira D., Roselli J., Rosen H., Rossi G., Rouanet P., Rullier E., Schiedeck T., Schiessel R., Schlachta C., Schwenk W., Seow-Choen F., Sim R., Sing W. K., Stamos M., Sternberg J., Tuckson W., Ugolini G., Vaccaro C., Vargas D., Vignali A., Vonen B., Weiss E., Wexner S., Whiteford M., Wibe A., Williams N., Woods R., Yamamoto T., Young-Fadok T., Augestad, K, Lindsetmo, R, Stulberg, J, Reynolds, H, Senagore, A, Champagne, B, Heriot, A, Leblanc, F, Delaney, C, Ambrosetti, P, Andujar, J, Baixuli, J, Balen, E, Baxter, N, Beck, D, Bemelman, W, Bergamaschi, R, Billingham, R, Birch, D, Bonardi, R, Bonardi, M, Bonjer, J, Braga, M, Buch, H, Buechler, M, Burnstein, M, Campbell, K, Caushaj, P, Celebrezze, J, Chang, G, Cheong, D, Cohen, J, Colak, T, Dhoore, A, Douglas, P, Dozois, E, Efron, J, Ellis, N, Enker, W, Fanelli, R, Fazio, V, Fleshman, J, Franklin, M, Fry, R, Garcia-Aguilar, J, Garcia-Granero, E, Habr-Gama, A, Hahnloser, D, Harris, G, Hasegawa, H, Holm, T, Horgan, P, Hyman, N, Irwin, T, Joh, Y, Jongen, J, Kaiser, A, Kang, S, Kariv, Y, Kennedy, R, Kessler, H, Khan, M, Kim, S, Krokowicz, P, Kwok, S, Lacy, A, Larson, D, Law, W, Lee, E, Lippert, H, Ludwig, K, Lynch, A, Macrae, H, Madbouly, K, Maeda, K, Marderstein, E, Marino, M, Marks, J, Maurer, C, Mcleod, R, Monson, J, Mortensen, N, Neary, P, Newstead, G, Obrien, D, Orangio, G, Orkin, B, Page, M, Pahlman, L, Panis, Y, Panton, N, Pennickx, F, Phang, T, Pinedo Mancilla, G, Post, S, Rafferty, J, Rajput, A, Reis Neto dos, J, Rivadeneira, D, Roselli, J, Rosen, H, Rossi, G, Rouanet, P, Rullier, E, Schiedeck, T, Schiessel, R, Schlachta, C, Schwenk, W, Seow-Choen, F, Sim, R, Sing, W, Stamos, M, Sternberg, J, Tuckson, W, Ugolini, G, Vaccaro, C, Vargas, D, Vignali, A, Vonen, B, Weiss, E, Wexner, S, Whiteford, M, Wibe, A, Williams, N, Woods, R, Yamamoto, T, Young-Fadok, T, Augestad K. M., Lindsetmo R. -O., Stulberg J., Reynolds H., Senagore A., Champagne B., Heriot A. G., Leblanc F., Delaney C. P., Ambrosetti P., Andujar J., Baixuli J., Balen E., Baxter N., Beck D., Bemelman W., Bergamaschi R., Billingham R., Birch D., Bonardi R., Bonardi M., Bonjer J., Braga M., Buch H., Buechler M., Burnstein M., Campbell K., Caushaj P., Celebrezze J., Chang G., Cheong D., Cohen J., Colak T., Dhoore A., Douglas P., Dozois E., Efron J., Ellis N., Enker W., Fanelli R. D., Fazio V., Fleshman J., Franklin M., Fry R., Garcia-Aguilar J., Garcia-Granero E., Habr-Gama A., Hahnloser D., Harris G., Hasegawa H., Holm T., Horgan P., Hyman N., Irwin T., Joh Y. G., Jongen J., Kaiser A., Kang S. B., Kariv Y., Kennedy R., Kessler H., Khan M., Kim S. H., Krokowicz P., Kwok S., Lacy A., Larson D., Law W. L., Lee E., Lippert H., Ludwig K., Lynch A. C., MacRae H., Madbouly K., Maeda K., Marderstein E., Marino M., Marks J., Maurer C., McLeod R., Monson J., Mortensen N., Neary P., Newstead G., OBrien D., Orangio G., Orkin B., Page M., Pahlman L., Panis Y., Panton N., Pennickx F., Phang T., Pinedo Mancilla G., Post S., Rafferty J., Rajput A., Reis Neto dos J. A., Rivadeneira D., Roselli J., Rosen H., Rossi G., Rouanet P., Rullier E., Schiedeck T., Schiessel R., Schlachta C., Schwenk W., Seow-Choen F., Sim R., Sing W. K., Stamos M., Sternberg J., Tuckson W., Ugolini G., Vaccaro C., Vargas D., Vignali A., Vonen B., Weiss E., Wexner S., Whiteford M., Wibe A., Williams N., Woods R., Yamamoto T., and Young-Fadok T.
- Abstract
Background Little is known regarding variations in preoperative treatment and practice for rectal cancer (RC) on an international level, yet practice variation may result in differences in recurrence and survival rates. Methods One hundred seventy-three international colorectal centers were invited to participate in a survey of preoperative management of rectal cancer. Results One hundred twenty-three (71%) responded, with a majority of respondents from North America, Europe, and Asia. Ninety-three percent have more than 5 years' experience with rectal cancer surgery. Fifty-five percent use CT scan, 35% MRI, 29% ERUS, 12% digital rectal examination and 1% PET scan in all RC cases. Seventyfour percent consider threatened circumferential margin (CRM) an indication for neoadjuvant treatment. Ninety-two percent prefer 5-FU-based long-course neoadjuvant chemoradiation therapy (CRT). A significant difference in practice exists between the US and non-US surgeons: poor histological differentiation as an indication for CRT (25% vs. 7.0%, p = 0.008), CRT for stage II and III rectal cancer (92% vs. 43%, p = 0.0001), MRI for all RC patients (20% vs. 42%, p = 0.03), and ERUS for all RC patients (43% vs. 21%, p = 0.01). Multidisciplinary team meetings significantly influence decisions for MRI (RR = 3.62), neoadjuvant treatment (threatened CRM, RR = 5.67, stage II III RR = 2.98), quality of pathology report (RR = 4.85), and sphincter-saving surgery (RR = 3.81). Conclusions There was little consensus on staging, neoadjuvant treatment, and preoperative management of rectal cancer. Regular multidisciplinary team meetings influence decisions about neoadjuvant treatment and staging methods.
- Published
- 2010
19. SIMULATION OF UNMANNED AERIAL VEHICLES WITH COMBINED RAMJET ENGINE APPLICATION SCENARIOS IN THE ATTACK OF A PROTECTED AIR TARGET
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Diyachuk, А. К., primary, Evdokimenkov, V. N., additional, Orkin, B. D., additional, Orkin, S. D., additional, and Sebryakov, G. G., additional
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- 2016
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20. Composition of an East Texas Lubricating Oil Distillate
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Orkin, B. A., primary, Bendoraitis, J. G., additional, Brown, B., additional, and Williams, R. H., additional
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21. Strangulated ileostomy evisceration following lateralizing mesh repair of parastomal hernia
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Ramly, E. P., primary, Crosslin, T., additional, Orkin, B., additional, and Popowich, D., additional
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- 2014
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22. Premature Red Blood Cells Have Decreased Aggregation and Enhanced Aggregability
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Arbell, D., primary, Orkin, B., additional, Bar-Oz, B., additional, Barshtein, G., additional, and Yedgar, S., additional
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- 2008
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23. Diverticular Disease: Management of the Difficult Surgical Case
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Orkin, B. A., primary
- Published
- 1998
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24. Interactive automated planning system for actions of aviation of different tactical designation against naval objects.
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D'yachuk, A., Orkin, B., and Orkin, S.
- Abstract
Interactive automated system designated for formation of rational scenarios of attacking naval groups, including aircraft carrier multipurpose groups, by means of various tactical aviation and air weapons is considered. This system is a program component of the complex of simulation mathematical models for attacking naval groups. This model makes it possible to reduce the influence of the human factor on the results of planning. [ABSTRACT FROM AUTHOR]
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- 2011
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25. 458. Unsaturated lactones and related substances . (a) Introduction . (b) Part I. Unsaturated γ-lactones from keto-acids. The position of the double bond.
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Kuehl, F. A., Linstead, R. P., and Orkin, B. A.
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- 1950
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26. 462. The third isomeric (cis-trans-) muconic acid.
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Elvidge, J. A., Linstead, R. P., Sims, Peter, and Orkin, B. A.
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- 1950
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27. 461. Unsaturated lactones and related substances. Part IV. Lactonic products derived from muconic acid.
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Elvidge, J. A., Linstead, R. P., Orkin, B. A., Sims, Peter, Baer, Harold, and Pattison, Dexter B.
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- 1950
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28. Perforated peptic ulcer in an adolescent girl.
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Schwartz S, Edden Y, Orkin B, and Erlichman M
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- 2012
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29. Hydroisomerization of Normal Paraffins over Fluorided Platinum-Alumina Catalysts
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Orkin, B. A., primary
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- 1969
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30. The Thermal Signature of Wound Healing.
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Benvenisti H, Cohen O, Feldman E, Assaf D, Jacob M, Bluestein E, Strechman G, Orkin B, Nachman-Farchy H, and Nissan A
- Abstract
Background: Despite major efforts in prevention, surgical site infections (SSIs) remain a burden on patients and the healthcare system and are associated with significant morbidity. SSIs are one of the costliest healthcare-associated infections. The diagnosis of SSIs is based mainly on clinical assessment, which may result in a delay in detection. The ability to detect SSIs in subclinical phase and initiate effective therapy earlier may reduce morbidity and hospital stay. In this study, we attempted to utilize long-wave infrared (LWIR) imaging to define the healing process of the surgical site and to detect abnormal healing., Methods: In this prospective study, 50 patients undergoing elective abdominal surgery had LWIR images of their incision obtained at determined intervals from their operation to discharge. Images were processed with proprietary algorithms to create a thermal topograph used to define the healing process., Results: Images of 45 patients were available for a final review. Of these 45 patients, 10 patients developed SSIs. Using the thermal topograph, 10 criteria for image analysis were defined, yielding a prediction of six out of the 10 SSIs and 35 out of the 35 normal healing wounds. Sensitivity was 60%, specificity was 100%, positive predictive value was 100%, and negative predictive value was 90.1%, with 92% accuracy. A preliminary program was created that allows trained users to methodically evaluate images providing them with a risk estimate., Conclusions: In this preliminary study, LWIR analysis of surgical wounds was able to identify normal and abnormal wound healing. Further large-scale studies are needed to validate results., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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31. Value of an interactive phone application in an established enhanced recovery program.
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Schlund D, Poirier J, Bhama AR, Hayden D, Saclarides T, Orkin B, and Favuzza J
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- Adolescent, Adult, Aged, Aged, 80 and over, Elective Surgical Procedures economics, Female, Humans, Length of Stay, Male, Medication Adherence, Middle Aged, Patient Readmission, Retrospective Studies, Smartphone, Surgical Wound Infection etiology, Young Adult, Colonic Diseases surgery, Enhanced Recovery After Surgery, Mobile Applications, Rectal Diseases surgery
- Abstract
Purpose: An interactive mobile phone application was added to an established Enhanced Recovery After Surgery (ERAS) program to determine the impact on ERAS compliance as well as clinical outcomes., Methods: We identified patients undergoing elective colorectal surgery enrolled in our ERAS program from February 2017 to July 2018. Patients enrolled in a phone application were compared with those not enrolled in terms of age, sex, diagnosis, operative approach, bowel preparation, oral intake and solid food intake, ERAS pathway adherence, and clinical outcomes., Results: A total of 289 patients were included: 147 enrolled and 142 not enrolled in the phone application. The mean age of enrollees was 53.0 years, compared with 58.3 years for the non-enrollees (p = 0.003). The mean ERAS pathway medication adherence for enrollees was 82.1% versus 76.8% for those not enrolled (p = 0.005). The mean LOS and SSI rates for those enrolled versus not enrolled in the phone application was 4.4 days versus 6.4 days (p = 0.006) and 3.4% versus 11.3% (p = 0.019), respectively. There was no significant difference in readmission rates between enrollees and non-enrollees (15% versus 10.6%, p = 0.345). The mean total cost of patients enrolled was $11,560; total cost of those not enrolled was $13,946 (p = 0.024)., Conclusions: Use of an interactive phone application is associated with improved medication ERAS adherence along with significant reduction in length of stay and SSI rates without increasing total cost.
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- 2020
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32. Common side closure type, but not stapler brand or oversewing, influences side-to-side anastomotic leak rates.
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Fleetwood VA, Gross KN, Alex GC, Cortina CS, Smolevitz JB, Sarvepalli S, Bakhsh SR, Poirier J, Myers JA, Singer MA, and Orkin BA
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- Adolescent, Adult, Aged, Aged, 80 and over, Diabetes Mellitus epidemiology, Equipment Design, Female, Humans, Intestines surgery, Male, Middle Aged, Multivariate Analysis, Operative Time, Retrospective Studies, Risk Factors, Surgical Stapling instrumentation, Young Adult, Anastomosis, Surgical methods, Anastomotic Leak etiology, Surgical Stapling methods
- Abstract
Background: Anastomotic leak (AL) increases costs and cancer recurrence. Studies show decreased AL with side-to-side stapled anastomosis (SSA), but none identify risk factors within SSAs. We hypothesized that stapler characteristics and closure technique of the common enterotomy affect AL rates., Methods: Retrospective review of bowel SSAs was performed. Data included stapler brand, staple line oversewing, and closure method (handsewn, HC; linear stapler [Barcelona technique], BT; transverse stapler, TX). Primary endpoint was AL. Statistical analysis included Fisher's test and logistic regression., Results: 463 patients were identified, 58.5% BT, 21.2% HC, and 20.3% TX. Covidien staplers comprised 74.9%, Ethicon 18.1%. There were no differences between stapler types (Covidien 5.8%, Ethicon 6.0%). However, AL rates varied by common side closure (BT 3.7% vs. TX 10.6%, p = 0.017), remaining significant on multivariate analysis., Conclusion: Closure method of the common side impacts AL rates. Barcelona technique has fewer leaks than transverse stapled closure. Further prospective evaluation is recommended., (Copyright © 2017. Published by Elsevier Inc.)
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- 2017
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33. Radiographic staging practices of newly diagnosed colorectal cancer vary according to medical specialty.
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Ma K, Nayak S, Li H, Evans K, Francescatti A, Brand MI, Orkin B, Hill M, Cameron J, Mobarhan S, Favuzza J, and Melson J
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- Academic Medical Centers statistics & numerical data, Aged, Cohort Studies, Colonoscopy, Colorectal Neoplasms diagnosis, Female, Hospitals, Community statistics & numerical data, Humans, Male, Middle Aged, Neoplasm Staging, Practice Guidelines as Topic, Rectal Neoplasms diagnosis, Rectal Neoplasms pathology, Retrospective Studies, Tomography, X-Ray Computed, Colorectal Neoplasms pathology, Colorectal Surgery standards, Gastroenterology standards, Guideline Adherence statistics & numerical data, Practice Patterns, Physicians' statistics & numerical data, Radiography, Thoracic statistics & numerical data
- Abstract
Background: Since 2008, multiple guidelines have endorsed incorporation of chest CT in the radiographic staging assessment of newly diagnosed colorectal cancer (CRC). Radiographic staging practices performed after CRC is detected have not been studied., Objective: To evaluate radiographic staging practices for newly diagnosed CRC between gastroenterologists versus non-gastroenterologists., Design: Observational cohort study., Setting: Single, tertiary-care referral center., Patients: Patients newly diagnosed with a T1 or higher stage CRC at time of colonoscopy between 2008 and 2013., Interventions: Radiographic staging., Main Outcome Measurements: Radiographic preoperative staging examinations ordered by gastroenterologists in comparison to those ordered by non-gastroenterology specialists., Results: This study included 277 patients with CRC newly diagnosed by colonoscopy. There were 141 total ordering physicians (68 gastroenterologists and 73 non-gastroenterologists). The majority of preoperative radiographic staging was performed by gastroenterologists (59.2% of patients, n = 164). Colorectal surgeons managed staging in 28.7% of patients (n = 47). Gastroenterologists were more likely to omit a staging chest CT than were non-gastroenterologists (64.6% vs 46.9%; P < .001). Physician practice setting, rectal location of tumor, and advanced endoscopic appearance of tumors were predictors of chest CT inclusion., Limitations: Single center, moderate sample size of both providers and patients., Conclusion: Gastroenterologists more frequently ordered the initial radiographic staging studies in newly diagnosed CRC patients. However, gastroenterologists were less likely to include chest CT in the initial staging of CRC despite current guideline recommendations to do so. If confirmed with further studies, educational efforts to improve compliance and standardization may be needed., (Copyright © 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
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34. Management of chronic intractable constipation in children.
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Kerur B, Kantekure K, Bonilla S, Orkin B, and Flores AF
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- Adolescent, Anastomosis, Surgical, Cecostomy, Child, Chronic Disease, Colectomy, Colon physiopathology, Constipation physiopathology, Constipation surgery, Defecography, Fecal Incontinence, Female, Gastrointestinal Motility, Humans, Ileostomy, Male, Manometry methods, Retrospective Studies, Treatment Outcome, Young Adult, Constipation therapy
- Abstract
Background: Chronic intractable constipation (CIC) is a debilitating disease that is challenging to manage. Treatment options in children include medications, enemas, and surgical management in selected cases., Method: We reviewed medical records of pediatric patients diagnosed as having CIC at Tufts Medical Center from 2005 to 2012. Demographic variables, diagnostic procedures, and medical and surgical outcomes were collected. Clinical outcome was defined using the Rome III criteria., Results: A total of 14 patients were included in the study (10 boys). The age range was 10 to 21 years. All of the patients had the diagnosis of CIC. Eleven patients had cecostomy placement. During the follow-up period, 10 patients underwent total abdominal colectomy with ileorectal anastomosis, 1 had total colectomy with ileostomy, and 1 had partial colectomy with colorectal anastomosis. Successful clinical outcome was reported in 7 patients with 3 patients reporting persistent fecal incontinence. Colonic motility studies were performed on 12 patients (colonic neuropathy in 11 patients and normal study in 1 patient). Defecography was consistent with isolated pelvic floor dysfunction in 1 patient, abnormal motility and anatomy in 1 patient, pelvic floor dysfunction and abnormal motility in 2 patients, and found abnormal motility only in 5. Defecography study was normal in 5 patients. All of the patients with abnormal colonic manometry underwent a surgical procedure., Conclusions: Anorectal manometry, colonic manometry, and defecography help in understanding the pathophysiology of defecation disorders in children. The majority of patients with abnormal colonic manometry underwent TAC-IRA. There was no statistical correlation between individual investigations (anorectal manometry, colonic manometry, and defecography) with surgical intervention (P > 0.35). TAC-IRA may be safe and useful intervention in a subset of patients when other treatment options have failed.
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- 2014
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35. Prevention of tumor recurrence and distant metastasis formation in a breast cancer mouse model by biodegradable implant of 131I-norcholesterol.
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Azab AK, Kleinstern J, Doviner V, Orkin B, Srebnik M, Nissan A, and Rubinstein A
- Subjects
- 19-Iodocholesterol administration & dosage, 19-Iodocholesterol chemistry, Animals, Cell Line, Tumor, Chitosan metabolism, Cross-Linking Reagents chemistry, Female, Glutaral chemistry, Half-Life, Hydrogels, Mammary Neoplasms, Experimental pathology, Mammary Neoplasms, Experimental surgery, Mice, Mice, Inbred BALB C, Models, Biological, Neoplasm Metastasis prevention & control, Oxidation-Reduction, Radiotherapy, Adjuvant, Secondary Prevention, Time Factors, Xenograft Model Antitumor Assays, 19-Iodocholesterol analogs & derivatives, Absorbable Implants, Brachytherapy methods, Chitosan chemistry, Mammary Neoplasms, Experimental radiotherapy
- Abstract
Brachytherapy has many potential roles in cancer therapy. However, major constraints are associated with placement and removal procedures of the brachytherapy machinery. An attractive approach would be the use of a biodegradable implant loaded with a radioisotope, thus enabling targeted radiotherapy, while reducing the need for surgical procedures for the removal of brachytherapy hardware. In this study, crosslinked chitosan (Ct) hydrogels were prepared and loaded with (131)I-norcholesterol ((131)I-NC). The radioactive hydrogels ((131)I-NC-Ct) were implanted adjacent to 4T1 cell-induced tumors in two different xenograft mice models either as primary therapy or surgical adjuvant therapy of breast cancer. Non-treated mice and mice implanted with naive (non-radioactive) hydrogels served as control groups. In the primary therapy model, the progression rate of the tumor was delayed by two weeks compared with the non-treated and the naive-implant control animals, resulting in a one-week extension in the survival of the treated animals. In the adjuvant therapy model, for the treatment of minimal residual disease, (131)I-NC-Ct implants were able to prevent 69% of tumor recurrence, and to prevent metastatic spread resulting in long-term survival, compared with 0% long-term survival of the non-treated and the naive control groups. Imaging of the hydrogel's in vivo elimination revealed a first order process with a half-life of 14 days. The degradation was caused by oxidation of the Ct as was assessed by in vitro H&E stain. Biodegradable radioactive implants are suggested as a novel platform for the delivery of brachytherapy. This radiotherapy regimen may prevent locoregional recurrence and metastatic spread after tumor resection.
- Published
- 2007
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36. Biocompatibility evaluation of crosslinked chitosan hydrogels after subcutaneous and intraperitoneal implantation in the rat.
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Azab AK, Doviner V, Orkin B, Kleinstern J, Srebnik M, Nissan A, and Rubinstein A
- Subjects
- 19-Iodocholesterol analogs & derivatives, 19-Iodocholesterol pharmacology, Animals, Biomarkers metabolism, Chitosan administration & dosage, Chitosan chemistry, Chitosan toxicity, Cross-Linking Reagents pharmacology, Foreign-Body Reaction, Hydrogels administration & dosage, Hydrogels toxicity, Inflammation, Organ Specificity drug effects, Peritoneum cytology, Peritoneum drug effects, Rats, Skin cytology, Skin drug effects, Biocompatible Materials administration & dosage, Biocompatible Materials chemistry, Biocompatible Materials pharmacology, Chitosan pharmacology, Hydrogels pharmacology, Materials Testing, Peritoneum metabolism, Prosthesis Implantation, Skin metabolism
- Abstract
The aim of the present study was to evaluate the toxicity of biodegradable hydrogels in the rat with a future aim of utilizing this hydrogel as a vehicle for brachytherapy delivery in cancer patients. Two types of chitosan hydrogels: fast degrading and slow degrading; were prepared and surgically implanted in rats. The adjacent tissue response to the gels after subcutaneous and intraperitoneal implantation was examined histologically and found to be identical to typical foreign body response and was milder than the response to absorbable surgical sutures (Vicril). Neither tissue damage nor gel fragments could be detected in distant organs (brain, heart, lungs, liver, spleen, kidney, and sternal bone marrow) after implantation of the hydrogels. The degradation mechanism of the gels was studied in vivo, and it was deduced that an oxidative process degraded the chitosan. Loading the hydrogels with a radioisotope (131I-norcholesterol) caused a severe tissue response and necrosis in adjacent tissues only at a distance of several microns. It is concluded that crosslinked chitosan implants could serve as alternative, biocompatible, and safe biodegradable devices for radioisotope delivery in brachytherapy for cancer., (Copyright (c) 2007 Wiley Periodicals, Inc.)
- Published
- 2007
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37. [Laparoscopic inguinal hernia repair in infants].
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Arbell D, Orkin B, and Udassin R
- Subjects
- Follow-Up Studies, Functional Laterality, Humans, Infant, Infant, Newborn, Male, Treatment Outcome, Hernia, Inguinal surgery, Laparoscopy methods
- Abstract
Background: The approach for treating contralateral pediatric inguinal hernias is still controversial. The options are delaying surgery on the contralateral side, automatic exploration, diagnostic laparoscopy through the ipsilateral hernia sac or laparoscopic repair. In children younger than 6 months, occult bilateral hernia is more prevalent, and the hernia sac is difficult for laparoscopic manipulation. We present our early experience with transabdominal laparoscopic hernia repair in infants younger than 6 months of age., Methods: Thirty four infants younger than 6 months and presenting with unilateral inguinal hernia were operated laparoscopically through a transabdominal approach. Patients were followed for a median of 11 months., Results: Thirty three of the operations were completed laparoscopically. There was a 38.2% incidence of occult bilateral hernia. There were 3 recurrences due to a technical mistake (6.4%), one minor operative complication (needle lost and retrieved) and one minor anesthetic complication (prolonged intubation). In one operation a mini laparotomy was performed to retrieve a needle that was disengaged whilst removed from the abdomen., Conclusions: Laparoscopic hernia repair is feasible in young infants. It may be particularly suitable for children younger than 6 months. Further studies are needed to assess long-term results.
- Published
- 2007
38. Imperforate anus, malrotation, and Hirschsprung's disease: a rare and important association.
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Arbell D, Gross E, Orkin B, Koplewitz BZ, and Udassin R
- Subjects
- Abnormalities, Multiple, Anus, Imperforate surgery, Digestive System Abnormalities complications, Digestive System Abnormalities surgery, Hirschsprung Disease surgery, Humans, Infant, Newborn, Kidney abnormalities, Male, Anus, Imperforate complications, Hirschsprung Disease complications
- Abstract
Imperforate anus and malrotation rarely occur together. The conjoint occurrence of these with Hirschsprung's disease is exceedingly rare, but failure to recognize its existence may lead to catastrophic results. We present a case in which awareness to this possibility caused early detection and avoidance of possible complications.
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- 2006
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39. Duodenojejunal atresia with absent dorsal mesentery, choledochal cyst, and malrotation in a premature newborn--a case report.
- Author
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Arbell D, Orkin B, Naveh Y, Gur I, and Udassin R
- Subjects
- Cholecystectomy, Choledochal Cyst surgery, Duodenal Obstruction surgery, Duodenostomy, Humans, Infant, Newborn, Male, Abnormalities, Multiple, Choledochal Cyst complications, Duodenal Obstruction congenital, Infant, Premature, Intestinal Atresia complications, Jejunum abnormalities, Mesentery abnormalities
- Abstract
We present the case of a premature baby who was born with the following conditions: an extensive atresia from the first part of the duodenum to the mid small bowel; malrotation of the distal part, in volvulus and in an "apple peel" configuration; no connection of the bile ducts to the bowel; and presence of a type II choledochal cyst. To our knowledge, this is the first case in which a combination of these anomalies is reported. A brief review of the relevant literature is also presented.
- Published
- 2006
- Full Text
- View/download PDF
40. Crosslinked chitosan implants as potential degradable devices for brachytherapy: in vitro and in vivo analysis.
- Author
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Azab AK, Orkin B, Doviner V, Nissan A, Klein M, Srebnik M, and Rubinstein A
- Subjects
- 19-Iodocholesterol analogs & derivatives, Animals, Biocompatible Materials administration & dosage, Cross-Linking Reagents, Drug Implants, Glutaral, Iodine Radioisotopes, Rats, Brachytherapy methods, Chitosan, Hydrogels
- Abstract
Compared with conventional external beam radiation, brachytherapy offers a superior therapeutic regimen. However, some major constraints are associated with its implementation, including the need of complicated procedures for device placement and removal. The purpose of this study was to examine whether crosslinked chitosan (Ct) implants could serve as potential biodegradable devices for brachytherapy. Ct was reacted with increasing amounts of glutaraldehyde to obtain hydrogels with different crosslinking densities, which were characterized chemically, thermally and mechanically. The effect of the dialysis medium conditions (ionic strength, osmolarity and pH) on the gel hydration and in vivo degradation was assessed. Two types of implants, slow and fast degrading gel (SDG and FDG, respectively), were prepared and implanted with or without Sudan Black (SB) in the rat. While SDG withstood for over a month, the FDG degraded within two weeks after implantation. The release kinetics of SB from the hydrogels verified their in vivo degradation properties. The incorporation of the radioactive compound (131)I-norcholesterol ((131)I-NC) into the SDG altered the degradation kinetics of the gel as reflected by the release kinetics of the radioactive marker. Eighty percent of (131)I-NC was released within a month after implantation, after which time, radioactivity was detected in the regional lymph nodes. Histological examination of the tissues surrounding the implants demonstrated negligible tissue response to the implants, when compared to biodegradable surgical sutures. It is concluded that hydrogels made of crosslinked Ct are potential novel, safe, degradable devices for brachytherapy.
- Published
- 2006
- Full Text
- View/download PDF
41. HIV-positive patients with anal carcinoma have poorer treatment tolerance and outcome than HIV-negative patients.
- Author
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Kim JH, Sarani B, Orkin BA, Young HA, White J, Tannebaum I, Stein S, and Bennett B
- Subjects
- Adult, Antineoplastic Agents therapeutic use, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Prognosis, Radiotherapy Dosage, Treatment Outcome, Anus Neoplasms complications, Anus Neoplasms therapy, HIV Infections complications
- Abstract
Purpose: Anal carcinoma is being found in HIV-positive patients with increasing frequency. Most patients are treated with combined chemotherapy and radiation. It was our impression that HIV-positive patients do not fare as well as HIV-negative patients in terms of both response to and tolerance of therapy., Methods: To test this hypothesis, we reviewed our experience with anal carcinoma and compared HIV-positive to HIV-negative patients by age, gender, sexual orientation, stage at diagnosis, treatment rendered, response to treatment, tolerance, and survival. From 1985 to 1998, 98 patients with anal neoplasms were treated. Seventy-three patients had invasive squamous-cell carcinoma (including cloacogenic carcinoma), and this cohort was analyzed. Thirteen patients were HIV positive and 60 were HIV negative., Results: The HIV-positive and HIV-negative groups differed significantly by age (42 vs. 62 years, P < 0.001), male gender (92 vs. 42 percent, P < 0.001), and homosexuality (46 vs. 15 percent, P < 0.05). There were no differences by stage at diagnosis or radiation dose received. Acute treatment major toxicity differed significantly (HIV positive 80 percent vs. HIV negative 30 percent; P < 0.005). Only 62 percent of HIV-positive patients were rendered disease free after initial therapy vs. 85 percent of HIV-negative patients (P = 0.11). Median time to cancer-related death was 1.4 vs. 5.3 years (P < 0.05). A survival model did not show age, gender, stage, or treatment to be independent predictors., Conclusion: We found that HIV-positive patients with anal carcinoma seem to be a different population from HIV-negative patients by age, gender, and sexual orientation. They have a poorer tolerance for combined therapy and a shorter time to cancer-related death. A strong trend to poorer initial response rate was also seen. These results suggest that the treatment of HIV-positive patients with anal carcinoma needs to be reassessed.
- Published
- 2001
- Full Text
- View/download PDF
42. Hemorrhoids: what the dermatologist should know.
- Author
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Orkin BA, Schwartz AM, and Orkin M
- Subjects
- Anal Canal anatomy & histology, Diagnosis, Differential, Hemorrhoids classification, Hemorrhoids complications, Hemorrhoids pathology, Hemorrhoids therapy, Humans, Physical Examination, Skin Diseases etiology, Skin Diseases pathology, Skin Diseases therapy, Hemorrhoids diagnosis, Skin Diseases diagnosis
- Abstract
Anorectal disorders are common and more than one half of the population will experience one at some time during their lives. It is important for the clinician to recognize the differences between internal and external hemorrhoids and other anorectal problems such as fissures, abscesses, fistulas, skin tags, and a variety of dermatologic conditions because the treatment is often different. This article will discuss the anatomy, pathophysiology, diagnosis, and treatment of internal and external hemorrhoids.
- Published
- 1999
- Full Text
- View/download PDF
43. Changes in circulating levels of HIV, CD4, and tissue expression of HIV in a patient with recent-onset ulcerative colitis treated by surgery. Case report.
- Author
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Silver S, Wahl SM, Orkin BA, and Orenstein JM
- Subjects
- Adult, CD4 Lymphocyte Count, Colitis, Ulcerative pathology, HIV Infections complications, HIV Infections pathology, Humans, Male, Colitis, Ulcerative surgery, HIV genetics, HIV Infections immunology, HIV Infections virology
- Abstract
Objective: To determine CD4+ T-cell count and circulating and tissue levels of HIV before and after surgery in a patient with recent-onset ulcerative colitis., Study Design/methods: CD4 lymphocytes and circulating and tissue HIV RNA levels were measured in an HIV-infected patient with ulcerative colitis before and after proctocolectomy., Results: Approximately 3 weeks prior to surgery for ulcerative colitis that was unresponsive to corticosteroids, the patient's CD4 count was 930 cells/mm3 and fell to 313 cells/mm3 within 10 days; the viral burden was approximately 80,000 RNA copies/mL. Tissue macrophages and lymphocytes in biopsy and resection specimens were shown to express high levels of HIV RNA by in situ hybridization. Five days postoperatively, the patient became asymptomatic and was discharged on tapering prednisone without antiretroviral agents. After surgery, the patient's CD4 count progressively rose, while viral RNA levels precipitously dropped. At 3, 6, and 15 weeks postoperatively, CD4 and viral RNA counts were 622 cells/mm3 and 31,300 RNA copies/mL, 843 cells/mm3 and 11,400 RNA copies/mL, and 747 cells/mm3 and 1500 RNA copies/mL, respectively., Conclusions: Circulating levels of HIV and CD4+ cells, as well as tissue expression of HIV, apparently can be influenced by localized inflammatory processes such as those occurring in inflammatory bowel disease.
- Published
- 1999
44. Which physiologic tests are useful in patients with constipation?
- Author
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Halverson AL and Orkin BA
- Subjects
- Adolescent, Adult, Aged, Anal Canal innervation, Anal Canal physiopathology, Compliance, Constipation etiology, Defecography, Electromyography, Female, Gastrointestinal Transit, Humans, Male, Manometry, Middle Aged, Neural Conduction, Pelvic Floor physiopathology, Constipation diagnosis
- Abstract
Purpose: Physiologic tests such as manometry, colonic transit times, balloon compliance, defecography, pudendal nerve latency, and electromyography are used to evaluate patients with severe constipation. Patients referred because of severe constipation between 1991 and 1996 were studied to examine the role that physiologic testing played in making a diagnosis and directing treatment., Methods: Of 139 patients referred for severe idiopathic constipation, physiologic testing was recommended in 127, and 104 patients underwent the studies. The pretesting impression was noted, and test results were evaluated to determine diagnostic accuracy. If a specific initial impression was documented, tests were classified as refuting it, confirming it or confirming and adding significant information. If there was no clear pretest impression, tests were evaluated for their ability to indicate a diagnosis. The patient's history also was evaluated to determine what information was most useful in making a diagnosis. Historical features including duration of constipation, symptoms consistent with outlet obstruction or dysmotility, age, associated urinary incontinence, and prior hysterectomy were analyzed. Data were collected prospectively, then reviewed by an independent observer., Results: Ninety-eight study patients remained after 29 were excluded who did not undergo the recommended studies (19) or because no initial impression was documented (10). In 43 patients (44 percent), testing did not provide additional useful information. In 8 patients, testing confirmed the initial impression and added information impacting the treatment plan. Test results clearly refuted the initial impression in only one patient. In 46 (47 percent) patients the initial impression was uncertain, and in 43 (94 percent) of these, testing aided in making the diagnosis. In three cases, the diagnosis remained uncertain after testing. Prior hysterectomy (P = 0.003), urinary incontinence (P < 0.001), and symptoms of pelvic outlet obstruction (P = 0.03) were associated with a high incidence of rectocele. Defecography and transit times were the most useful tests. Surprisingly, symptoms of outlet obstruction or dysmotility did not show an overall correlation with transit times., Conclusions: In one-half of these patients with severe constipation, physiologic testing added significant information, leading to a specific diagnosis. Pretesting history and symptoms did not predict which patients were most likely to benefit from these studies.
- Published
- 1998
- Full Text
- View/download PDF
45. Perianal manifestations of human immunodeficiency virus infection: experience with 260 patients.
- Author
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Barrett WL, Callahan TD, and Orkin BA
- Subjects
- Adult, Anus Diseases complications, Anus Diseases mortality, Anus Diseases therapy, Female, HIV Infections complications, HIV Infections mortality, Humans, Male, Middle Aged, Prospective Studies, Rectal Diseases complications, Rectal Diseases mortality, Rectal Diseases therapy, Risk Factors, Treatment Outcome, Anus Diseases epidemiology, HIV Infections epidemiology, Rectal Diseases epidemiology
- Abstract
Purpose: Individuals infected with the human immunodeficiency virus often have disorders affecting the anorectum. These disorders may be complex and difficult to treat. We reported our early experience with 40 human immunodeficiency virus-positive patients with perianal disorders in 1990. We now present our series of 260 consecutive human immunodeficiency virus-positive patients with perianal disorders who underwent evaluation between 1989 and 1996 to examine the distribution of disorders, their treatments, and outcomes., Method: Patients were identified at initial presentation and followed prospectively., Results: Two-hundred forty-nine (96 percent) of 260 patients were male, with an average age of 34.9 (range, 19-58) years. Average duration of human immunodeficiency virus positivity was 5 years, 5 months, with a maximum of 11 years, 5 months. Median CD4 count was 175 (range, 2-1,100) cells/mm3. Only 89 (34 percent) patients satisfied the criteria of the Centers for Disease Control and Prevention's for acquired immunodeficiency syndrome at presentation. The most frequent major presenting symptoms were anorectal pain (55 percent), a mass (19 percent), and blood in the stool (16 percent). Risk factors included homosexuality (75 percent) and a prior history of sexually transmitted disease (45 percent). Forty different perianal disorders were identified, which were categorized as benign noninfectious (18), infectious (14), neoplastic (6), and septic (2). The most common disorders were condyloma (42 percent), fistula (34 percent), fissure (32 percent), and abscess (25 percent). Neoplasms were present in 19 patients (7 percent). One hundred seventy-one patients (66 percent) had more than one disorder, with an average of 2.9 disorders among these patients. Four hundred eighty-five procedures were performed on 178 patients (2.7/patient), with no mortalities and a 2 percent complication rate. Thirty-one patients (12 percent) died during the course of follow-up, but anorectal disease was the cause of death in only two patients., Conclusions: Perianal manifestations of human immunodeficiency virus infection are common, often multiple, and varied. Patients with perianal disorders seek treatment throughout the course of the human immunodeficiency virus infection, and a perianal condition may be this disease's initial manifestation. Although recurrence is common and healing delayed, improved overall management of human immunodeficiency virus infection and a healthier human immunodeficiency virus-positive patient population have improved the outcome of surgical intervention in human immunodeficiency virus-infected patients with perianal disorders.
- Published
- 1998
- Full Text
- View/download PDF
46. Squamous cell carcinoma arising in an unhealed wound in Crohn's disease.
- Author
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Sarani B and Orkin BA
- Subjects
- Abdomen surgery, Abscess surgery, Biopsy, Buttocks, Carcinoma, Squamous Cell radiotherapy, Cell Transformation, Neoplastic pathology, Chronic Disease, Crohn Disease surgery, Diagnosis, Differential, Drainage, Female, Follow-Up Studies, Humans, Immunosuppressive Agents adverse effects, Inguinal Canal, Intestinal Diseases surgery, Intestinal Fistula surgery, Middle Aged, Muscle Neoplasms radiotherapy, Pain, Palliative Care, Perineum surgery, Reoperation, Skin Neoplasms radiotherapy, Vaginal Neoplasms radiotherapy, Wound Healing, Carcinoma, Squamous Cell pathology, Crohn Disease pathology, Muscle Neoplasms pathology, Perineum pathology, Skin Neoplasms pathology, Vaginal Neoplasms pathology
- Abstract
A 49-year-old black woman with a 23-year history of Crohn's disease came to our clinic; she had a squamous cell carcinoma arising in an unhealed perineal wound 16 years after abdominoperineal resection (APR). We report this case to show the potential for malignant degeneration in such wounds. This patient had had multiple procedures for fistulotomies and incision and drainage of abscesses and, ultimately, an APR. After the APR, she had a persistent perineal wound, which did not fully heal despite extensive local and systemic therapy. Our examination revealed a chronic wound involving the entire perineum and vagina, including the labia, both inguinal folds, and the intergluteal cleft. Biopsies showed moderately differentiated squamous cell carcinoma throughout. We believe healing may be impaired in patients who have Crohn's disease, with a significant risk of unhealed perineal wounds after APR. Chronic unhealing wounds may progress to carcinoma, and this propensity toward transformation may be increased by immunosuppression. Complaints of persistent pain and unhealing wounds in the absence of infection in patients with Crohn's disease suggest the possibility of malignancy and biopsy is recommended.
- Published
- 1997
- Full Text
- View/download PDF
47. Isolated colonic neurofibroma manifested by massive lower gastrointestinal bleeding and intussusception.
- Author
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Abramson LP, Orkin BA, and Schwartz AM
- Subjects
- Colectomy, Colonic Polyps complications, Fatal Outcome, Humans, Male, Middle Aged, Postoperative Complications, Prolapse, Rectum pathology, Respiratory Distress Syndrome etiology, Colonic Diseases etiology, Colonic Neoplasms complications, Gastrointestinal Hemorrhage etiology, Intussusception etiology, Neurofibroma complications
- Abstract
We report a case of rare solitary neurofibroma of the transverse colon in a patient without neurofibromatosis. The patient was found to have an intussuscepting tumor prolapsing transanally, with massive lower gastrointestinal bleeding. This case represents only the second documented report of an isolated colonic neurofibroma.
- Published
- 1997
- Full Text
- View/download PDF
48. The best operation for rectal prolapse.
- Author
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Jacobs LK, Lin YJ, and Orkin BA
- Subjects
- Colorectal Surgery methods, Humans, Physical Examination, Rectal Prolapse diagnosis, Rectal Prolapse etiology, Surgical Mesh, Treatment Outcome, Rectal Prolapse surgery, Rectum surgery
- Abstract
Rectal prolapse remains a disorder for which the cause is not clearly understood and the best method of management is debated. Because the natural history of prolapse frequently leads to complications of incontinence and constipation, we believe that all patients presenting with internal and external prolapse should be considered for repair. Although the type of operative repair recommended may vary, it is clear that all patients with external rectal prolapse should be offered some type of repair. What is not clear from the literature is the appropriate management of those patients with internal prolapse. As shown in the George Washington University experience, surgery is rarely performed for isolated internal prolapse. Most patients who present with internal prolapse also have an associated enterocele, rectocele, or cystocele. Repair of the internal prolapse and the associated disorder may benefit many of these patients. If internal prolapse is an isolated finding, it is not clear to what extent the prolapse is responsible for the patient's symptoms, and repair is generally not advised. These guidelines are easy to enumerate but may be difficult to practice in some patients. Therefore, ongoing evaluation of clinical results is critical to improve our understanding of these disorders. This discussion has outlined the current theories of the cause of rectal prolapse, the symptoms and findings patients present with, and the possible approaches to repair.
- Published
- 1997
- Full Text
- View/download PDF
49. Transanal endoscopic microsurgery. Initial registry results.
- Author
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Smith LE, Ko ST, Saclarides T, Caushaj P, Orkin BA, and Khanduja KS
- Subjects
- Adult, Aged, Aged, 80 and over, Endoscopy adverse effects, Female, Humans, Length of Stay, Male, Microsurgery adverse effects, Middle Aged, Neoplasm Recurrence, Local, Proctoscopy adverse effects, Treatment Outcome, Adenoma surgery, Anus Neoplasms surgery, Carcinoma surgery, Endoscopy methods, Microsurgery methods, Proctoscopy methods, Registries
- Abstract
Unlabelled: Transanal endoscopic microsurgery (TEM) was first used on a regular basis in the United States in 1990. Because there is a sole source of instrumentation, the surgeons who use this equipment are known to us. Thus, this earliest registry is a compilation of data based on most patients who underwent TEM in the United States from 1990 to 1994., Method: One hundred fifty-three cases were voluntarily registered by six surgeons. Pathology included 54 carcinomas, 82 adenomas, and 17 other entities. Most resections were full thickness. Fifty percent of cases were out of reach of standard instruments. Complication rate, hospital stay, and blood loss were recorded. Technical difficulties at time of surgery (9 percent), early complications (15 percent), and late complications (5 percent) have been tabulated., Results: Recurrence rates for carcinoma were 10 percent for T1, 40 percent for T2, and 66 percent for T3 stages. Failures were treated by abdominoperineal resection or low anterior resection. Adenomas recurred in 11 percent, but these recurrences were small and easily treatable., Conclusion: TEM has a low complication rate. By carefully selecting small, superficial cancers and adenomas, TEM results in superior outcome over other approaches to the mid and upper rectum.
- Published
- 1996
- Full Text
- View/download PDF
50. Excellent outcome using selective criteria for rectocele repair.
- Author
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Murthy VK, Orkin BA, Smith LE, and Glassman LM
- Subjects
- Constipation etiology, Fecal Incontinence etiology, Female, Follow-Up Studies, Hernia complications, Hernia diagnosis, Herniorrhaphy, Humans, Male, Middle Aged, Patient Selection, Rectal Diseases complications, Rectal Diseases diagnosis, Time Factors, Treatment Outcome, Rectal Diseases surgery
- Abstract
Purpose: The aim of this study was to review our experience with patients with rectoceles using very selective criteria for operative repair and to critically review our surgical results., Methods: This is a review of patients selected for rectocele repair between 1989 and 1994., Results: Two hundred seventy-nine patients were evaluated for pelvic outlet symptoms in our clinic. Defecography was performed in 180 patients; rectocele was seen in 143 patients (79 percent; 135 females and 8 males). On physical examination, 132 patients had a palpable rectocele (73 percent). Rectocele repair was recommended for 35 patients (13 percent); 33 (32 females and 1 male) underwent this procedure. Mean age was 55 (range, 16-78) years. Although many patients complained of constipation, incontinence and pelvic pain, in these 33 patients criteria for repair included the sensation of a vaginal mass or bulge that required digital support and/or rectal digitizing for evacuation (58 percent), retention of barium in the rectocele on defecography (55 percent), or a very large rectocele with internal anterior rectal wall prolapse (6 percent). A hysterectomy had been performed previously in 47 percent of women repaired. Rectocele repair was performed by a standard transanal approach in 31 patients and transabdominally in 2 patients. Hospital stay averaged 3.7 (range, 1-8) days. Few postoperative complications occurred; urinary retention was the most common (18 percent). All patients were followed postoperatively, and 26 patients (79 percent) answered a standardized questionnaire. Mean follow-up was 31 (range, 5-64) months. Eighty percent of patients questioned who initially complained of a vaginal mass or bulge reported complete resolution (significant improvement by the sign test, P < 0.5). Subjectively, 92 percent of patients questioned reported improvement in their preoperative symptoms and satisfaction with the operation., Conclusion: Rectoceles are frequently identified during defecography, which is performed for pelvic floor complaints, yet are often asymptomatic. In contrast to other recent reports of rectocele repair, our data indicate that careful selection of patients using specific criteria may result in very good clinical results.
- Published
- 1996
- Full Text
- View/download PDF
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