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2. Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers

Author

Tumbo, Anneth-Mwasi, Schindler, Tobias, Dangy, Jean-Pierre, Orlova-Fink, Nina, Bieri, Jose Raso, Mpina, Maximillian, Milando, Florence A., Juma, Omar, Hamad, Ali, Nyakarungu, Elizabeth, Chemba, Mwajuma, Mtoro, Ali, Ramadhan, Kamaka, Olotu, Ally, Makweba, Damas, Mgaya, Stephen, Stuart, Kenneth, Perreau, Matthieu, Stapleton, Jack T., Jongo, Said, Hoffman, Stephen L., Tanner, Marcel, Abdulla, Salim, and Daubenberger, Claudia

Published
2021
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5. Additional file 5 of Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers

Author

Anneth-Mwasi Tumbo, Schindler, Tobias, Dangy, Jean-Pierre, Orlova-Fink, Nina, Bieri, Jose Raso, Mpina, Maximillian, Milando, Florence A., Juma, Omar, Hamad, Ali, Nyakarungu, Elizabeth, Mwajuma Chemba, Mtoro, Ali, Kamaka Ramadhan, Olotu, Ally, Damas Makweba, Mgaya, Stephen, Stuart, Kenneth, Perreau, Matthieu, Stapleton, Jack T., Jongo, Said, Hoffman, Stephen L., Tanner, Marcel, Abdulla, Salim, and Daubenberger, Claudia

Abstract

Additional file 5. Table 1 Sensitivity and standard curve ranges for the 45 cytokines, chemokines and growth factors analysed in this study. The tables shows the 45 cytokines, chemokines and growth factors their sensitivities and standard curve ranges as provided by manufacturer.

Published
2021
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6. Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers

Author

Tumbo, Anneth-Mwasi, primary, Schindler, Tobias, additional, Dangy, Jean-Pierre, additional, Orlova-Fink, Nina, additional, Bieri, Jose Raso, additional, Mpina, Maximillian, additional, Milando, Florence A., additional, Juma, Omar, additional, Hamad, Ali, additional, Nyakarungu, Elizabeth, additional, Chemba, Mwajuma, additional, Mtoro, Ali, additional, Ramadhan, Kamaka, additional, Olotu, Ally, additional, Makweba, Damas, additional, Mgaya, Stephen, additional, Stuart, Kenneth, additional, Perreau, Matthieu, additional, Stapleton, Jack T., additional, Jongo, Said, additional, Hoffman, Stephen L., additional, Tanner, Marcel, additional, Abdulla, Salim, additional, and Daubenberger, Claudia, additional

Published
2021
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8. Role of Human Pegivirus Infections in Whole P. falciparum Sporozoite Vaccination and Controlled Human Malaria Infection in African Volunteers

Author

Tumbo, Anneth-Mwasi, primary, Schindler, Tobias, additional, Dangy, Jean-Pierre, additional, Orlova-Fink, Nina, additional, Bieri, Jose Raso, additional, Mpina, Maximillian, additional, Milando, Florence A., additional, Juma, Omar, additional, Hamad, Ally, additional, Nyakarungu, Elizabeth, additional, Chemba, Mwajuma, additional, Mtoro, Ali, additional, Ramadhan, Kamaka, additional, Olotu, Ally, additional, Makweba, Damas, additional, Mgaya, Stephen, additional, Stuart, Kenneth, additional, Perreau, Matthieu, additional, Stapleton, Jack T., additional, Jongo, Said, additional, Hoffman, Stephen L., additional, Tanner, Marcel, additional, Abdulla, Salim, additional, and Daubenberger, Claudia, additional

Published
2020
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10. Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells

Author

Lee, Guinevere Q., primary, Orlova-Fink, Nina, additional, Einkauf, Kevin, additional, Chowdhury, Fatema Z., additional, Sun, Xiaoming, additional, Harrington, Sean, additional, Kuo, Hsiao-Hsuan, additional, Hua, Stephane, additional, Chen, Hsiao-Rong, additional, Ouyang, Zhengyu, additional, Reddy, Kavidha, additional, Dong, Krista, additional, Ndung’u, Thumbi, additional, Walker, Bruce D., additional, Rosenberg, Eric S., additional, Yu, Xu G., additional, and Lichterfeld, Mathias, additional

Published
2017
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12. Inactivated trivalent influenza vaccination is associated with lower mortality among patients with COVID-19 in Brazil

Author

Fink, Gu¨nther, Orlova-Fink, Nina, Schindler, Tobias, Grisi, Sandra, Ferrer, Ana Paula S, Daubenberger, Claudia, and Brentani, Alexandra

Abstract

ObjectiveTo estimate associations between trivalent influenza vaccination and COVID-19 mortality as well as severe clinical outcomes among hospitalised patients.DesignRetrospective observational study.SettingThis study was conducted among hospitalised patients with COVID-19 in Brazil.ParticipantsWe analysed all hospitalised patients with COVID-19 with available vaccination information captured in Brazil’s national electronic respiratory infection data system between 1 January 2020 and 23 June 2020.Main outcome measuresThe primary outcomes were age-specific mortality rates of hospitalised patients with COVID-19 with and without recent inactivated trivalent influenza vaccination.ResultsA total of 53 752 clinically confirmed COVID-19 cases were analysed. Controlling for health facility of treatment, comorbidities as well as an extensive range of sociodemographic factors, patients who received a recent influenza vaccine experienced on average 7% lower odds of needing intensive care treatment (95% CI 0.87 to 0.98), 17% lower odds of requiring invasive respiratory support (95% CI 0.77 to 0.88) and 16% lower odds of death (95% CI 0.78 to 0.90). Protective effects were larger when the vaccine was administered after onset of symptoms as well as among younger patients.ConclusionPatients with COVID-19 with recent inactivated influenza vaccination experience significantly better health outcomes than non-vaccinated patients in Brazil. Beneficial off-target effects of influenza vaccination through trained innate immune responses seem plausible and need to be further explored. Large-scale promotion of influenza vaccines seems advisable, especially in populations at high risk for severe COVID-19 disease progression.

Published
2021
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