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The comparative analysis of the data on the expression of the same modulating protein MX, obtained on the same biological materials by Western blotting and surface plasmone resonance tests was shown to provide in most cases a semiquantitative opinion as to modulation of MX affinity to its specific target (effector X protein) under the experimental action of F. This is doubtlessly to offer additional possibilities for the prediction and differential diagnosis of a number of diseases, including cancer.

Effect of the inhibitors of polyamines biosynthesis on completely or partially hormone-dependant breast tumors (mouse Ca755 carcinoma and Walker W-256 carcinosarcoma) is essentially special: in contrary to hormone-dependant tumors, this effect may be not only breaking but stimulating as well. Change-over from one to another mode of reaction is conditioned, most probable, by hormonal status, which is determined by one or another estral cycle phase. Biochemical mechanisms of this change-over are closely connected with polyamines metabolism, namely the degree of polyamines (especially spermine) interconvertion and physiological reactivity level of the system controlling expression of ornithin-decarboxilase. At that, the first of these pathways is predominant for completely hormone-dependant Ca755 and the second one -for partially hormone-dependant W-256.

In two populations of contemporary generations of non-strain mice was found a considerable shift of interhemispheric asymmetry the relative activity of the right hemisphere being increased in comparison with the known data. Quantitative evaluation and the character of this shift in the two populations were different. Changes observed are suggested to be a manifestation of adaptive response of the organism to environmental pollution.

The cocarcinogenic effect of chronic influenza infection was shown to be mediated by M-cholinergic structures. Administration of a M-anticholinergic agent in low dose at the key stages of chronic influenza infection development was followed by a nearly complete suppression of its cocarcinogenic action. N-anticholinergic agents failed to exert such effect.

The immune status of mice has been assessed by the whole complex of data. The permanent action of low-level radiation has been shown to suppress considerably the rate of reactions of the delayed-type hypersensitivity and "graft versus host" disease, as well as NK and specific cytolytic T-lymphocyte activity. The dynamics of accumulation and the levels of antiviral antibodies in the serum, lung and trachea extracts are virtually invariable. The resistance of experimental animals to influenza is lower than that of non-irradiated mice of the same line and age. The data obtained indicate that the immune disturbances revealed are connected not only with the alteration of lymphoid cell populations, but also with the alteration of the immune regulation mechanisms.

The influence of two schemes of laser acupuncture on some cell-mediated and humoral immunity characteristics of mice, as well as on their nonspecific antiviral resistance, in acute experimental influenza infection has been studied. The use of both schemes has been found to considerably decrease the severity of infection, enhancing the activity of lymphocytes of infected mice in the graft versus host reaction, the O2-producing activity of alveolar macrophages and modulating the ratio of antihemagglutinins and nonspecific antiviral inhibitors in the blood serum.

Intensification of cocarcinogenic effect of chronic influenza infection (10 months after virus instillation) in BALB/c mice was obtained by polymetallic aerosol inhalation 5 or 6 months after infection. An increase of malignant neoplasms incidence was accompanied by a decrease of the cytoproliferative activity in the thymus and spleen. The immunopathogenic and cocarcinogenic effects were maximal when the aerosol treatment was carried out 6 months after infection.

In experiments with rats, it was shown that whole-body irradiation of animals with a dose of 500 Gy causes a decrease in the catecholamine mediator content of the truncus cerebri during the first minutes following irradiation. A possible mechanism of the changes observed is discussed.

The method of coupled estimation of the hypoxic and radioprotective effect has demonstrated that the hypoxic mechanism does not play an essential role in the radioprotective action of phenylephrine hydrochloride.

In acute experiments on rats different agents and their combinations were used to induced hypoxia. In order to estimate the oxygen status of crus bone marrow by taking measurements in subcutaneous fat by a standard electrode with small working surface several electrodes should be used simultaneously. A correlation between subcutaneous and bone-marrow hypoxic tension caused by the hypoxia-induced agents was associated with the subcutaneous fat zone under study. However, in any case, a pronounced pO2 decrease in bone marrow might occur upon slight hypoxic tension.

The effect of interferon (IF) on the activity of multipurpose hepatic oxidases (MHO) in animals in the process of metastatic tumour development as well as interaction of IF and vinblastine (VBL) in the cell culture have been studied. IF activates MHO under conditions of their inhibition at the beginning of the tumour development and inhibits them to the normal level under activation in the postmetastatic period. Contrary to the data obtained in vivo IF does not decrease the toxicity of VBL for the tumour cells in vitro. The data obtained evidence for the modulating effect of IF on the MHO system under the tumour development.

Tumor disposition in mice with chronic influenza infection was shown to be completed chiefly during secondary increase in viral reproduction. This condition presents with various systemic disorders and a pronounced increase in susceptibility to the cocarcinogenic effect of polymetal aerosols.