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9 results on '"Oropeza, Celina"'

1. Next-generation sequencing of HIV-1 single genome amplicons

Author

Kijak, Gustavo H., Sanders-Buell, Eric, Pham, Phuc, Harbolick, Elizabeth A., Oropeza, Celina, O’Sullivan, Anne Marie, Bose, Meera, Beckett, Charmagne G., Milazzo, Mark, Robb, Merlin L., Peel, Sheila A., Scott, Paul T., Michael, Nelson L., Armstrong, Adam W., Kim, Jerome H., Brett-Major, David M., and Tovanabutra, Sodsai

Published
2019
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2. Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Author

Kijak, Gustavo H., primary, Sanders-Buell, Eric, additional, Chenine, Agnes-Laurence, additional, Eller, Michael A., additional, Goonetilleke, Nilu, additional, Thomas, Rasmi, additional, Leviyang, Sivan, additional, Harbolick, Elizabeth A., additional, Bose, Meera, additional, Pham, Phuc, additional, Oropeza, Celina, additional, Poltavee, Kultida, additional, O’Sullivan, Anne Marie, additional, Billings, Erik, additional, Merbah, Melanie, additional, Costanzo, Margaret C., additional, Warren, Joanna A., additional, Slike, Bonnie, additional, Li, Hui, additional, Peachman, Kristina K., additional, Fischer, Will, additional, Gao, Feng, additional, Cicala, Claudia, additional, Arthos, James, additional, Eller, Leigh A., additional, O’Connell, Robert J., additional, Sinei, Samuel, additional, Maganga, Lucas, additional, Kibuuka, Hannah, additional, Nitayaphan, Sorachai, additional, Rao, Mangala, additional, Marovich, Mary A., additional, Krebs, Shelly J., additional, Rolland, Morgane, additional, Korber, Bette T., additional, Shaw, George M., additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Tovanabutra, Sodsai, additional, and Kim, Jerome H., additional

Published
2017
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3. Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Author

Kijak, Gustavo H., primary, Sanders-Buell, Eric, additional, Chenine, Agnes-Laurence, additional, Eller, Michael A., additional, Goonetilleke, Nilu, additional, Thomas, Rasmi, additional, Leviyang, Sivan, additional, Harbolick, Elizabeth A., additional, Bose, Meera, additional, Pham, Phuc, additional, Oropeza, Celina, additional, Poltavee, Kultida, additional, O’Sullivan, Anne Marie, additional, Billings, Erik, additional, Merbah, Melanie, additional, Costanzo, Margaret C., additional, Warren, Joanna A., additional, Slike, Bonnie, additional, Li, Hui, additional, Peachman, Kristina K., additional, Fischer, Will, additional, Gao, Feng, additional, Cicala, Claudia, additional, Arthos, James, additional, Eller, Leigh A., additional, O’Connell, Robert J., additional, Sinei, Samuel, additional, Maganga, Lucas, additional, Kibuuka, Hannah, additional, Nitayaphan, Sorachai, additional, Rao, Mangala, additional, Marovich, Mary A., additional, Krebs, Shelly J., additional, Rolland, Morgane, additional, Korber, Bette T., additional, Shaw, George M., additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Tovanabutra, Sodsai, additional, and Kim, Jerome H., additional

Published
2017
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4. Cryptic Multiple HIV-1 Infection Revealed by Early, Frequent, and Deep Sampling during Acute Infection

Author

Kijak, Gustavo Hernan, primary, Sanders-Buell, Eric, additional, Chenine, Agnes-Laurance, additional, Eller, Michael, additional, Goonetilleke, Nilu, additional, Thomas, Rasmi, additional, Leviyang, Sivan, additional, Harbolick, Elizabeth, additional, Bose, Meera, additional, Pham, Phuc, additional, Oropeza, Celina, additional, Poltavee, Kultida, additional, O'Sullivan, Anne Marie, additional, Merbah, Melanie, additional, Costanzo, Margaret, additional, Li, Hui, additional, Fischer, Will, additional, Gao, Feng, additional, Eller, Leigh Anne, additional, O'Connell, Robert J., additional, Sinei, Samuel, additional, Maganga, Lucas, additional, Kibuuka, Hannah, additional, Nitayaphan, Sorachai, additional, Rolland, Morgane, additional, Korber, Bette, additional, McCutchan, Francine, additional, Shaw, George, additional, Michael, Nelson, additional, Robb, Merlin, additional, Tovanabutra, Sodsai, additional, and Kim, Jerome, additional

Published
2014
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5. No Selection for Env with Shorter Variable Loops in Acute HIV-1 Infection

Author

Rolland, Morgane, primary, Tovanabutra, Sodsai, additional, Sanders-Buell, Eric, additional, Bose, Meera, additional, Sullivan, Anne Marie O, additional, Howell, Shana, additional, Poltavee, Kultida, additional, Lee, Jenica, additional, Ibitamuno, Grace, additional, Muhammad, Sevan, additional, Ahani, Bahar, additional, Lepore, Steven, additional, Harbolick, Elizabeth, additional, Oropeza, Celina, additional, Patterson, Joey, additional, Bates, Adam, additional, Lazzaro, Michelle, additional, Kijak, Gustavo, additional, Dommaraju, Kalpana, additional, Herr, Christopher, additional, Eller, Leigh Anne, additional, Nitayaphan, Sorachai, additional, Rono, Kathleen, additional, Maganga, Lucas, additional, Sekiziyivu, Arthur, additional, Michael, Nelson, additional, Kim, Jerome, additional, and Robb, Merlin, additional

Published
2014
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6. Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection.

Author

Tovanabutra, Sodsai, Sirijatuphat, Rujipas, Pham, Phuc T., Bonar, Lydia, Harbolick, Elizabeth A., Bose, Meera, Song, Hongshuo, Chang, David, Oropeza, Celina, O'Sullivan, Anne Marie, Balinang, Joyce, Kroon, Eugene, Colby, Donn J., Sacdalan, Carlo, Hellmuth, Joanna, Chan, Phillip, Prueksakaew, Peeriya, Pinyakorn, Suteeraporn, Jagodzinski, Linda L., and Sutthichom, Duanghathai

Subjects
CENTRAL nervous system, CENTRAL nervous system physiology, CEREBROSPINAL fluid, CEREBROSPINAL fluid examination, INFECTION
Abstract

HIV-1 disseminates to a broad range of tissue compartments during acute HIV-1 infection (AHI). The central nervous system (CNS) can serve as an early and persistent site of viral replication, which poses a potential challenge for HIV-1 remission strategies that target the HIV reservoir. CNS compartmentalization is a key feature of HIV-1 neuropathogenesis. Thus far, the timing of how early CNS compartmentalization develops after infection is unknown. We examined whether HIV-1 transmitted/founder (T/F) viruses differ between CNS and blood during AHI using single-genome sequencing of envelope gene and further examined subregions in pol and env using next-generation sequencing in paired plasma and cerebrospinal fluid (CSF) from 18 individuals. Different proportions of mostly minor variants were found in six of the eight multiple T/F-infected individuals, indicating enrichment of some variants in CSF that may lead to significant compartmentalization in the later stages of infection. This study provides evidence for the first time that HIV-1 compartmentalization in the CNS can occur within days of HIV-1 exposure in multiple T/F infections. Further understanding of factors that determine enrichment of T/F variants in the CNS, as well as potential long-term implications of these findings for persistence of HIV-1 reservoirs and neurological impairment in HIV, is needed. [ABSTRACT FROM AUTHOR]

Published
2019
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7. Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Author

O’Connell, Robert J., Michael, Nelson L., Oropeza, Celina, Arthos, James, Bose, Meera, Nitayaphan, Sorachai, Slike, Bonnie, Thomas, Rasmi, Chenine, Agnes-Laurence, Tovanabutra, Sodsai, Marovich, Mary A., O’Sullivan, Anne Marie, Rolland, Morgane, Maganga, Lucas, Merbah, Melanie, Warren, Joanna A., Shaw, George M., Billings, Erik, Goonetilleke, Nilu, Cicala, Claudia, Eller, Michael A., Poltavee, Kultida, Kibuuka, Hannah, Pham, Phuc, Kim, Jerome H., Sanders-Buell, Eric, Korber, Bette T., Fischer, Will, Li, Hui, Peachman, Kristina K., Leviyang, Sivan, Sinei, Samuel, Harbolick, Elizabeth A., Eller, Leigh A., Krebs, Shelly J., Gao, Feng, Costanzo, Margaret C., Rao, Mangala, Robb, Merlin L., and Kijak, Gustavo H.

Subjects
3. Good health
Abstract

In order to inform the rational design of HIV-1 preventive and cure interventions it is critical to understand the events occurring during acute HIV-1 infection (AHI). Using viral deep sequencing on six participants from the early capture acute infection RV217 cohort, we have studied HIV-1 evolution in plasma collected twice weekly during the first weeks following the advent of viremia. The analysis of infections established by multiple transmitted/founder (T/F) viruses revealed novel viral profiles that included: a) the low-level persistence of minor T/F variants, b) the rapid replacement of the major T/F by a minor T/F, and c) an initial expansion of the minor T/F followed by a quick collapse of the same minor T/F to low frequency. In most participants, cytotoxic T-lymphocyte (CTL) escape was first detected at the end of peak viremia downslope, proceeded at higher rates than previously measured in HIV-1 infection, and usually occurred through the exploration of multiple mutational pathways within an epitope. The rapid emergence of CTL escape variants suggests a strong and early CTL response. Minor T/F viral strains can contribute to rapid and varied profiles of HIV-1 quasispecies evolution during AHI. Overall, our results demonstrate that early, deep, and frequent sampling is needed to investigate viral/host interaction during AHI, which could help identify prerequisites for prevention and cure of HIV-1 infection.

8. Cryptic Multiple HIV-1 Infection Revealed by Early, Frequent, and Deep Sampling during Acute Infection.

Author

Sanders-Buell, Eric, Chenine, Agnes-Laurance, Eller, Michael, Goonetilleke, Nilu, Thomas, Rasmi, Leviyang, Sivan, Harbolick, Elizabeth, Bose, Meera, Pham, Phuc, Oropeza, Celina, Poltavee, Kultida, O'Sullivan, Anne Marie, Merbah, Melanie, Costanzo, Margaret, Li, Hui, Fischer, Will, Gao, Feng, Eller, Leigh Anne, O'Connell, Robert J., and Sinei, Samuel

Abstract

An abstract of the article "Cryptic Multiple HIV-1 Infection Revealed by Early, Frequent, and Deep Sampling during Acute Infection" by Gustavo Hernan Kijak, Eric Sanders-Buell, Agnes-Laurance Chenine and colleagues is presented.

Published
2014
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9. No Selection for Env with Shorter Variable Loops in Acute HIV-1 Infection.

Author

Tovanabutra, Sodsai, Sanders-Buell, Eric, Bose, Meera, Sullivan, Anne Marie O, Howell, Shana, Poltavee, Kultida, Lee, Jenica, Ibitamuno, Grace, Muhammad, Sevan, Ahani, Bahar, Lepore, Steven, Harbolick, Elizabeth, Oropeza, Celina, Patterson, Joey, Bates, Adam, Lazzaro, Michelle, Kijak, Gustavo, Dommaraju, Kalpana, Herr, Christopher, and Eller, Leigh Anne

Abstract

An abstract of the article "No Selection for Env with Shorter Variable Loops in Acute HIV-1 Infection" by Morgane Rolland, Sodsai Tovanabutra, Eric Sanders-Buell and colleagues is presented.

Published
2014
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