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Analyzes native legume species for their tolerance to high soil aluminium (Al) levels in terms of the Al, iron (Fe) and calcium (Ca) contents in different plant organs and spatial distribution in two contrasting savanna sites in Venezuela. Soil characteristics; Harvested plants including Chamaecrista flexiuosa, Clitoria guianensis, Galactia jussieuana, Stylosanthes elegans and Zornia curvata; Results of analysis suggesting Al contents in nodules were below detectable values; Ca and Fe contents in legumes.

The aim of this study was to determine the CYP2D6: * 4, * 6 and * 10 gene variants frequency and to predict the metabolizer phenotype in a sample of 145 unrelated apparently healthy individuals residing in the state of Aragua, Venezuela. Genotypes were determined by Polymerase chain reaction assays followed by restriction endonucleases digestion. The metabolizer phenotype prediction was made based on the activity score system. The frequencies of CYP2D6 * 4, * 6 and * 10 allelic variants were 14.5%, 0.3% and 1%. A significant percentage of individuals were categorized as heterozygote-extensive/intermediate (23.5%) and poor metabolizers (4.1%), this information has potential clinical impact, because the CYP2D6 protein is involved in the metabolism of drugs frequently prescribed as: carvedilol, captopril, chloroquine, codeine, fluoxetine, fluvastatin, haloperidol, idarubicin, indinavir, imatinib, loperamide, nifedipine, ondansetron and tamoxifen.