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2. Experimental corroboration of the Mulheran-Blackman explanation of the scale invariance in thin film growth: the case of InAs quantum dots on GaAs(001)

Author

Fanfoni, M., Placidi, E., Arciprete, F., Orsini, E., Patella, F., and Balzarotti, A.

Subjects
Condensed Matter - Materials Science
Abstract

Mulheran and Blackman have provided a simple and clear explanation of the scale invariance of the island size distribution at the early stage of film growth [Phil. Mag. Lett. 72, 55 (1995)]. Their theory is centered on the concept of capture zone properly identified by Voronoi cell. Here we substantiate experimentally their theory by studying the scale invariance of InAs quantum dots (QDs) forming on GaAs(001) substrate. In particular, we show that the volume distributions of QDs well overlap the corrisponding experimental distributions of the Voronoi-cell areas. The interplay between the experimental data and the numerical simulations allowed us to determine the spatial correlation length among QDs.

Published
2006

6. Reperfusion therapies and in-hospital outcomes for ST-elevation myocardial infarction in europe. the ACVC-EAPCI EORP STEMI registry of the european society of cardiology

Author

Zeymer, U., Ludman, P., Danchin, N., Kala, P., Laroche, C., Sadeghi, M., Caporale, R., Shaheen, S. M., Legutko, J., Iakobsishvili, Z., Alhabib, K. F., Motovska, Z., Studencan, M., Mimoso, J., Becker, D., Alexopoulos, D., Kereseselidze, Z., Stojkovic, S., Zelveian, P., Goda, A., Mirrakhimov, E., Bajraktari, G., Al-Farhan, H., Serpytis, P., Raungaard, B., Marandi, T., Moore, A. M., Quinn, M., Karjalainen, P. P., Tatu-Chitolu, G., Gale, C. P., Maggioni, A. P., Weidinger, F., Sinnaeve, P., Ferrari, R., Karamfilov, K., Lidon, R. -M., Kereselidze, Z., Iakobishvili, Z., Erglis, A., Kedev, S., Dudek, D., Tatu-Chitoiu, G., Shlyakhto, E., Bunc, M., Mourali, M. S., Konte, M., Larras, F., Lefrancq, E. F., Mekhaldi, S., Shuka, N., Pavli, E., Tafaj, E., Gishto, T., Dibra, A., Duka, A., Gjana, A., Kristo, A., Knuti, G., Demiraj, A., Dado, E., Hasimi, E., Simoni, L., Siqeca, M., Sisakian, H., Hayrapetyan, H., Markosyan, S., Galustyan, L., Arustamyan, N., Kzhdryan, H., Pepoyan, S., Zirkik, A., Von Lewinski, D., Paetzold, S., Kienzl, I., Matyas, K., Neunteufl, T., Nikfardjam, M., Neuhold, U., Mihalcz, A., Glaser, F., Steinwender, C., Reiter, C., Grund, M., Hrncic, D., Hoppe, U., Hammerer, M., Hinterbuchner, L., Hengstenberg, C., Delle Karth, G., Lang, I., Winkler, W., Hasun, M., Kastner, J., Havel, C., Derntl, M., Oberegger, G., Hajos, J., Adlbrecht, C., Publig, T., Leitgeb, M. -C., Wilfing, R., Jirak, P., C. -Y., Ho, Puskas, L., Schrutka, L., Spinar, J., Parenica, J., Hlinomaz, O., Fendrychova, V., Semenka, J., Sikora, J., Sitar, J., Groch, L., Rezek, M., Novak, M., Kramarikova, P., Stasek, J., Dusek, J., Zdrahal, P., Polasek, R., Karasek, J., Seiner, J., Sukova, N., Varvarovsky, I., Lazarak, T., Novotny, V., Matejka, J., Rokyta, R., Volovar, S., Belohlavek, J., Siranec, M., Kamenik, M., Kralik, R., Ravkilde, J., Jensen, S. E., Villadsen, A., Villefrance, K., Schmidt Skov, C., Maeng, M., Moeller, K., Hasan-Ali, H., Ahmed, T. A., Hassan, M., Elguindy, A., Farouk Ismail, M., Ibrahim Abd El-Aal, A., El-Sayed Gaafar, A., Magdy Hassan, H., Ahmed Shafie, M., Nabil El-Khouly, M., Bendary, A., Darwish, M., Ahmed, Y., Amin, O. A., Abdelhakim, A., Abosaif, K., Kandil, H., Galal, M. A. G., El Hefny, E. E., El Sayed, M., Aly, K., Mokarrab, M., Osman, M., Abdelhamid, M., Mantawy, S., Ali, M. R., Kaky, S. D., Khalil, V. A., Saraya, M. E. A., Talaat, A., Nabil, M., Mounir, W. M., Mahmoud, K., Aransa, A., Kazamel, G., Anwar, S., Al-Habbaa, A., Abd El Monem, M., Ismael, A., Amin Abu-Sheaishaa, M., Abd Rabou, M. M., Hammouda, T. M. A., Moaaz, M., Elkhashab, K., Ragab, T., Rashwan, A., Rmdan, A., Abdelrazek, G., Ebeid, H., Soliman Ghareeb, H., Farag, N., Zaki, M., Seleem, M., Torki, A., Youssef, M., Allah Nasser, N. A., Rafaat, A., Selim, H., Makram, M. M., Khayyal, M., Malasi, K., Madkour, A., Kolib, M., Alkady, H., Nagah, H., Yossef, M., Wafa, A., Mahfouz, E., Faheem, G., Magdy Moris, M., Ragab, A., Ghazal, M., Mabrouk, A., El-Masry, M., Naseem, M., Samir, S., Reinmets, J., Allvee, M., Saar, A., Ainla, T., Vaide, A., Kisseljova, M., Pakosta, U., Eha, J., Lotamois, K., Sia, J., Myllymaki, J., Pinola, T., Paana, T., Mikkelsson, J., Ampio, M., Tsivilasvili, J., Zurab, P., Agladze, R., Melia, A., Gogoberidze, D., Khubua, N., Totladze, L., Metreveli, I., Chikovani, A., Eitel, I., Poss, J., Werner, M., Constantz, A., Ahrens, C., Tolksdorf, H., Klinger, S., Sack, S., Heer, T., Lekakis, J., Kanakakis, I., Xenogiannis, I., Ermidou, K., Makris, N., Ntalianis, A., Katsaros, F., Revi, E., Kafkala, K., Mihelakis, E., Diakakis, G., Grammatikopoulos, K., Voutsinos, D., Xanthopoulou, I., Mplani, V., Foussas, S., Papakonstantinou, N., Patsourakos, N., Dimopoulos, A., Derventzis, A., Athanasiou, K., Vassilikos, V. P., Papadopoulos, C., Tzikas, S., Vogiatzis, I., Datsios, A., Galitsianos, I., Koutsampasopoulos, K., Grigoriadis, S., Douras, A., Baka, N., Spathis, S., Kyrlidis, T., Hatzinikolaou, H., Kiss, R. G., Nowotta, F., Toth, K., Szabo, S., Lakatos, C., Jambrik, Z., Ruzsa, J., Ruzsa, Z., Rona, S., Toth, J., Vargane Kosik, A., Toth, K. S. B., Nagy, G. G., Ondrejko, Z., Koromi, Z., Botos, B., Pourmoghadas, M., Salehi, A., Massoumi, G., Soleimani, A., Sarrafzadegan, N., Roohafza, H., Azarm, M., Mirmohammadsadeghi, A., Rajabi, D., Rahmani, Y., Siabani, S., Najafi, F., Hamzeh, B., Karim, H., Siabani, H., Saleh, N., Charehjoo, H., Zamzam, L., Al-Temimi, G., Al-Yassin, A., Mohammad, A., Ridha, A., Al-Saedi, G., Atabi, N., Sabbar, O., Mahmood, S., Dakhil, Z., Yaseen, I. F., Almyahi, M., Alkenzawi, H., Alkinani, T., Alyacopy, A., Kearney, P., Twomey, K., Shlomo, N., Beigel, R., Caldarola, P., Rutigliano, D., Sublimi Saponetti, L., Locuratolo, N., Palumbo, V., Scherillo, M., Formigli, D., Canova, P., Musumeci, G., Roncali, F., Metra, M., Lombardi, C., Visco, E., Rossi, L., Meloni, L., Montisci, R., Pippia, V., Marchetti, M. F., Congia, M., Cacace, C., Luca, G., Boscarelli, G., Indolfi, C., Ambrosio, G., Mongiardo, A., Spaccarotella, C., De Rosa, S., Canino, G., Critelli, C., Chiappetta, D., Battista, F., Gabrielli, D., Marziali, A., Bernabo, P., Navazio, A., Guerri, E., Manca, F., Gobbi, M., Oreto, Giuseppe, Andò, Giuseppe, Carerj, Scipione, Saporito, Francesco, Cimmino, Michele, Rigo, F., Zuin, G., Tuccillo, B., Scotto DI Uccio, F., Irace, L., Lorenzoni, G., Meloni, I., Merella, P., Polizzi, G. M., Pino, R., Marzilli, M., Morrone, D., Caravelli, P., Orsini, E., Mosa, S., Piovaccari, G., Santarelli, A., Cavazza, C., Romeo, F., Fedele, F., Mancone, M., Straito, M., Salvi, N., Scarparo, P., Severino, P., Razzini, C., Massaro, G., Cinque, A., Gaudio, C., Barilla, F., Torromeo, C., Porco, L., Mei, M., Iorio, R., Nassiacos, D., Barco, B., Sinagra, G., Falco, L., Priolo, L., Perkan, A., Strana, M., Percuku, L., Berisha, G., Mziu, B., Beishenkulov, M., Abdurashidova, T., Toktosunova, A., Kaliev, K., Serpytis, R., Butkute, E., Lizaitis, M., Broslavskyte, M., Xuereb, R. G., Mercieca Balbi, M., Paris, E., Buttigieg, L., Musial, W., Dobrzycki, S., Dubicki, A., Kazimierczyk, E., Tycinska, A., Wojakowski, W., Kalanska-Lukasik, B., Ochala, A., Wanha, W., Dworowy, S., Sielski, J., Janion, M., Janion-Sadowska, A., Wojtasik-Bakalarz, J., Bryniarski, L., Peruga, J. Z., Jonczyk, M., Jankowski, L., Klecha, A., Michalowska, J., Brzezinski, M., Kozmik, T., Kowalczyk, T., Adamczuk, J., Maliszewski, M., Kuziemka, P., Plaza, P., Jaros, A., Pawelec, A., Sledz, J., Bartus, S., Zmuda, W., Bogusz, M., Wisnicki, M., Szastak, G., Adamczyk, M., Suska, M., Czunko, P., Opolski, G., Kochman, J., Tomaniak, M., Miernik, S., Paczwa, K., Witkowski, A., Opolski, M. P., Staruch, A. D., Kalarus, Z., Honisz, G., Mencel, G., Swierad, M., Podolecki, T., Marques, J., Azevedo, P., Pereira, M. A., Gaspar, A., Monteiro, S., Goncalves, F., Leite, L., Manuel Lopes Dos Santos, W., Amado, J., Pereira, D., Silva, B., Caires, G., Neto, M., Rodrigues, R., Correia, A., Freitas, D., Lourenco, A., Ferreira, F., Sousa, F., Portugues, J., Calvo, L., Almeida, F., Alves, M., Silva, A., Caria, R., Seixo, F., Militaru, C., Ionica, E., Istratoaie, O., Florescu, M., Lipnitckaia, E., Osipova, O., Konstantinov, S., Bukatov, V., Vinokur, T., Egorova, E., Nefedova, E., Levashov, S., Gorbunova, A., Redkina, M., Karaulovskaya, N., Bijieva, F., Babich, N., Smirnova, O., Filyanin, R., Eseva, S., Kutluev, A., Chlopenova, A., Shtanko, A., Kuppar, E., Shaekhmurzina, E., Ibragimova, M., Mullahmetova, M., Chepisova, M., Kuzminykh, M., Betkaraeva, M., Namitokov, A., Khasanov, N., Baleeva, L., Galeeva, Z., Magamedkerimova, F., Ivantsov, E., Tavlueva, E., Kochergina, A., Sedykh, D., Kosmachova, E., Skibitskiy, V., Porodenko, N., Litovka, K., Ulbasheva, E., Niculina, S., Petrova, M., Harkov, E., Tsybulskaya, N., Lobanova, A., Chernova, A., Kuskaeva, A., Kuskaev, A., Ruda, M., Zateyshchikov, D., Gilarov, M., Konstantinova, E., Koroleva, O., Averkova, A., Zhukova, N., Kalimullin, D., Borovkova, N., Tokareva, A., Buyanova, M., Khaisheva, L., Pirozhenko, A., Novikova, T., Yakovlev, A., Tyurina, T., Lapshin, K., Moroshkina, N., Kiseleva, M., Fedorova, S., Krylova, L., Duplyakov, D., Semenova, Y., Rusina, A., Ryabov, V., Syrkina, A., Demianov, S., Reitblat, O., Artemchuk, A., Efremova, E., Makeeva, E., Menzorov, M., Shutov, A., Klimova, N., Shevchenko, I., Elistratova, O., Kostyuckova, O., Islamov, R., Budyak, V., Ponomareva, E., Ullah Jan, U., Alshehri, A. M., Sedky, E., Alsihati, Z., Mimish, L., Selem, A., Malik, A., Majeed, O., Altnji, I., Alshehri, M., Aref, A., Alhabib, K., Aldosary, M., Tayel, S., Abd Alrahman, M., Asfina, K. N., Abdin Hussein, G., Butt, M., Markovic Nikolic, N., Obradovic, S., Djenic, N., Brajovic, M., Davidovic, A., Romanovic, R., Novakovic, V., Dekleva, M., Spasic, M., Dzudovic, B., Jovic, Z., Cvijanovic, D., Veljkovic, S., Ivanov, I., Cankovic, M., Jarakovic, M., Kovacevic, M., Trajkovic, M., Mitov, V., Jovic, A., Hudec, M., Gombasky, M., Sumbal, J., Bohm, A., Baranova, E., Kovar, F., Samos, M., Podoba, J., Kurray, P., Obona, T., Remenarikova, A., Kollarik, B., Verebova, D., Kardosova, G., Alusik, D., Macakova, J., Kozlej, M., Bayes-Genis, A., Sionis, A., Garcia Garcia, C., Duran Cambra, A., Labata Salvador, C., Rueda Sobella, F., Sans Rosello, J., Vila Perales, M., Oliveras Vila, T., Ferrer Massot, M., Baneras, J., Lekuona, I., Zugazabeitia, G., Fernandez-Ortiz, A., Viana Tejedor, A., Ferrera, C., Alvarez, V., DIaz-Castro, O., Agra-Bermejo, R. M., Gonzalez-Cambeiro, C., Gonzalez-Babarro, E., Domingo-Del Valle, J., Royuela, N., Burgos, V., Canteli, A., Castrillo, C., Cobo, M., Ruiz, M., Abu-Assi, E., Garcia Acuna, J., Zeymer, U., Ludman, P., Danchin, N., Kala, P., Laroche, C., Sadeghi, M., Caporale, R., Shaheen, S. M., Legutko, J., Iakobsishvili, Z., Alhabib, K. F., Motovska, Z., Studencan, M., Mimoso, J., Becker, D., Alexopoulos, D., Kereseselidze, Z., Stojkovic, S., Zelveian, P., Goda, A., Mirrakhimov, E., Bajraktari, G., Al-Farhan, H., Serpytis, P., Raungaard, B., Marandi, T., Moore, A. M., Quinn, M., Karjalainen, P. P., Tatu-Chitolu, G., Gale, C. P., Maggioni, A. P., Weidinger, F., Sinnaeve, P., Ferrari, R., Karamfilov, K., Lidon, R. -M., Kereselidze, Z., Iakobishvili, Z., Erglis, A., Kedev, S., Dudek, D., Tatu-Chitoiu, G., Shlyakhto, E., Bunc, M., Mourali, M. S., Konte, M., Larras, F., Lefrancq, E. F., Mekhaldi, S., Shuka, N., Pavli, E., Tafaj, E., Gishto, T., Dibra, A., Duka, A., Gjana, A., Kristo, A., Knuti, G., Demiraj, A., Dado, E., Hasimi, E., Simoni, L., Siqeca, M., Sisakian, H., Hayrapetyan, H., Markosyan, S., Galustyan, L., Arustamyan, N., Kzhdryan, H., Pepoyan, S., Zirkik, A., Von Lewinski, D., Paetzold, S., Kienzl, I., Matyas, K., Neunteufl, T., Nikfardjam, M., Neuhold, U., Mihalcz, A., Glaser, F., Steinwender, C., Reiter, C., Grund, M., Hrncic, D., Hoppe, U., Hammerer, M., Hinterbuchner, L., Hengstenberg, C., Delle Karth, G., Lang, I., Winkler, W., Hasun, M., Kastner, J., Havel, C., Derntl, M., Oberegger, G., Hajos, J., Adlbrecht, C., Publig, T., Leitgeb, M. -C., Wilfing, R., Jirak, P., Ho, C. -Y., Puskas, L., Schrutka, L., Spinar, J., Parenica, J., Hlinomaz, O., Fendrychova, V., Semenka, J., Sikora, J., Sitar, J., Groch, L., Rezek, M., Novak, M., Kramarikova, P., Stasek, J., Dusek, J., Zdrahal, P., Polasek, R., Karasek, J., Seiner, J., Sukova, N., Varvarovsky, I., Lazarak, T., Novotny, V., Matejka, J., Rokyta, R., Volovar, S., Belohlavek, J., Siranec, M., Kamenik, M., Kralik, R., Ravkilde, J., Jensen, S. E., Villadsen, A., Villefrance, K., Schmidt Skov, C., Maeng, M., Moeller, K., Hasan-Ali, H., Ahmed, T. A., Hassan, M., Elguindy, A., Farouk Ismail, M., Ibrahim Abd El-Aal, A., El-Sayed Gaafar, A., Magdy Hassan, H., Ahmed Shafie, M., Nabil El-Khouly, M., Bendary, A., Darwish, M., Ahmed, Y., Amin, O. A., Abdelhakim, A., Abosaif, K., Kandil, H., Galal, M. A. G., El Hefny, E. E., El Sayed, M., Aly, K., Mokarrab, M., Osman, M., Abdelhamid, M., Mantawy, S., Ali, M. R., Kaky, S. D., Khalil, V. A., Saraya, M. E. A., Talaat, A., Nabil, M., Mounir, W. M., Mahmoud, K., Aransa, A., Kazamel, G., Anwar, S., Al-Habbaa, A., Abd El Monem, M., Ismael, A., Amin Abu-Sheaishaa, M., Abd Rabou, M. M., Hammouda, T. M. A., Moaaz, M., Elkhashab, K., Ragab, T., Rashwan, A., Rmdan, A., Abdelrazek, G., Ebeid, H., Soliman Ghareeb, H., Farag, N., Zaki, M., Seleem, M., Torki, A., Youssef, M., Allah Nasser, N. A., Rafaat, A., Selim, H., Makram, M. M., Khayyal, M., Malasi, K., Madkour, A., Kolib, M., Alkady, H., Nagah, H., Yossef, M., Wafa, A., Mahfouz, E., Faheem, G., Magdy Moris, M., Ragab, A., Ghazal, M., Mabrouk, A., El-Masry, M., Naseem, M., Samir, S., Reinmets, J., Allvee, M., Saar, A., Ainla, T., Vaide, A., Kisseljova, M., Pakosta, U., Eha, J., Lotamois, K., Sia, J., Myllymaki, J., Pinola, T., Paana, T., Mikkelsson, J., Ampio, M., Tsivilasvili, J., Zurab, P., Agladze, R., Melia, A., Gogoberidze, D., Khubua, N., Totladze, L., Metreveli, I., Chikovani, A., Eitel, I., Poss, J., Werner, M., Constantz, A., Ahrens, C., Tolksdorf, H., Klinger, S., Sack, S., Heer, T., Lekakis, J., Kanakakis, I., Xenogiannis, I., Ermidou, K., Makris, N., Ntalianis, A., Katsaros, F., Revi, E., Kafkala, K., Mihelakis, E., Diakakis, G., Grammatikopoulos, K., Voutsinos, D., Xanthopoulou, I., Mplani, V., Foussas, S., Papakonstantinou, N., Patsourakos, N., Dimopoulos, A., Derventzis, A., Athanasiou, K., Vassilikos, V. P., Papadopoulos, C., Tzikas, S., Vogiatzis, I., Datsios, A., Galitsianos, I., Koutsampasopoulos, K., Grigoriadis, S., Douras, A., Baka, N., Spathis, S., Kyrlidis, T., Hatzinikolaou, H., Kiss, R. G., Nowotta, F., Toth, K., Szabo, S., Lakatos, C., Jambrik, Z., Ruzsa, J., Ruzsa, Z., Rona, S., Toth, J., Vargane Kosik, A., Toth, K. S. B., Nagy, G. G., Ondrejko, Z., Koromi, Z., Botos, B., Pourmoghadas, M., Salehi, A., Massoumi, G., Soleimani, A., Sarrafzadegan, N., Roohafza, H., Azarm, M., Mirmohammadsadeghi, A., Rajabi, D., Rahmani, Y., Siabani, S., Najafi, F., Hamzeh, B., Karim, H., Siabani, H., Saleh, N., Charehjoo, H., Zamzam, L., Al-Temimi, G., Al-Yassin, A., Mohammad, A., Ridha, A., Al-Saedi, G., Atabi, N., Sabbar, O., Mahmood, S., Dakhil, Z., Yaseen, I. F., Almyahi, M., Alkenzawi, H., Alkinani, T., Alyacopy, A., Kearney, P., Twomey, K., Shlomo, N., Beigel, R., Caldarola, P., Rutigliano, D., Sublimi Saponetti, L., Locuratolo, N., Palumbo, V., Scherillo, M., Formigli, D., Canova, P., Musumeci, G., Roncali, F., Metra, M., Lombardi, C., Visco, E., Rossi, L., Meloni, L., Montisci, R., Pippia, V., Marchetti, M. F., Congia, M., Cacace, C., Luca, G., Boscarelli, G., Indolfi, C., Ambrosio, G., Mongiardo, A., Spaccarotella, C., De Rosa, S., Canino, G., Critelli, C., Chiappetta, D., Battista, F., Gabrielli, D., Marziali, A., Bernabo, P., Navazio, A., Guerri, E., Manca, F., Gobbi, M., Oreto, G., Ando, G., Carerj, S., Saporito, F., Cimmino, M., Rigo, F., Zuin, G., Tuccillo, B., Scotto DI Uccio, F., Irace, L., Lorenzoni, G., Meloni, I., Merella, P., Polizzi, G. M., Pino, R., Marzilli, M., Morrone, D., Caravelli, P., Orsini, E., Mosa, S., Piovaccari, G., Santarelli, A., Cavazza, C., Romeo, F., Fedele, F., Mancone, M., Straito, M., Salvi, N., Scarparo, P., Severino, P., Razzini, C., Massaro, G., Cinque, A., Gaudio, C., Barilla, F., Torromeo, C., Porco, L., Mei, M., Iorio, R., Nassiacos, D., Barco, B., Sinagra, G., Falco, L., Priolo, L., Perkan, A., Strana, M., Percuku, L., Berisha, G., Mziu, B., Beishenkulov, M., Abdurashidova, T., Toktosunova, A., Kaliev, K., Serpytis, R., Butkute, E., Lizaitis, M., Broslavskyte, M., Xuereb, R. G., Mercieca Balbi, M., Paris, E., Buttigieg, L., Musial, W., Dobrzycki, S., Dubicki, A., Kazimierczyk, E., Tycinska, A., Wojakowski, W., Kalanska-Lukasik, B., Ochala, A., Wanha, W., Dworowy, S., Sielski, J., Janion, M., Janion-Sadowska, A., Wojtasik-Bakalarz, J., Bryniarski, L., Peruga, J. Z., Jonczyk, M., Jankowski, L., Klecha, A., Michalowska, J., Brzezinski, M., Kozmik, T., Kowalczyk, T., Adamczuk, J., Maliszewski, M., Kuziemka, P., Plaza, P., Jaros, A., Pawelec, A., Sledz, J., Bartus, S., Zmuda, W., Bogusz, M., Wisnicki, M., Szastak, G., Adamczyk, M., Suska, M., Czunko, P., Opolski, G., Kochman, J., Tomaniak, M., Miernik, S., Paczwa, K., Witkowski, A., Opolski, M. P., Staruch, A. D., Kalarus, Z., Honisz, G., Mencel, G., Swierad, M., Podolecki, T., Marques, J., Azevedo, P., Pereira, M. A., Gaspar, A., Monteiro, S., Goncalves, F., Leite, L., Manuel Lopes Dos Santos, W., Amado, J., Pereira, D., Silva, B., Caires, G., Neto, M., Rodrigues, R., Correia, A., Freitas, D., Lourenco, A., Ferreira, F., Sousa, F., Portugues, J., Calvo, L., Almeida, F., Alves, M., Silva, A., Caria, R., Seixo, F., Militaru, C., Ionica, E., Istratoaie, O., Florescu, M., Lipnitckaia, E., Osipova, O., Konstantinov, S., Bukatov, V., Vinokur, T., Egorova, E., Nefedova, E., Levashov, S., Gorbunova, A., Redkina, M., Karaulovskaya, N., Bijieva, F., Babich, N., Smirnova, O., Filyanin, R., Eseva, S., Kutluev, A., Chlopenova, A., Shtanko, A., Kuppar, E., Shaekhmurzina, E., Ibragimova, M., Mullahmetova, M., Chepisova, M., Kuzminykh, M., Betkaraeva, M., Namitokov, A., Khasanov, N., Baleeva, L., Galeeva, Z., Magamedkerimova, F., Ivantsov, E., Tavlueva, E., Kochergina, A., Sedykh, D., Kosmachova, E., Skibitskiy, V., Porodenko, N., Litovka, K., Ulbasheva, E., Niculina, S., Petrova, M., Harkov, E., Tsybulskaya, N., Lobanova, A., Chernova, A., Kuskaeva, A., Kuskaev, A., Ruda, M., Zateyshchikov, D., Gilarov, M., Konstantinova, E., Koroleva, O., Averkova, A., Zhukova, N., Kalimullin, D., Borovkova, N., Tokareva, A., Buyanova, M., Khaisheva, L., Pirozhenko, A., Novikova, T., Yakovlev, A., Tyurina, T., Lapshin, K., Moroshkina, N., Kiseleva, M., Fedorova, S., Krylova, L., Duplyakov, D., Semenova, Y., Rusina, A., Ryabov, V., Syrkina, A., Demianov, S., Reitblat, O., Artemchuk, A., Efremova, E., Makeeva, E., Menzorov, M., Shutov, A., Klimova, N., Shevchenko, I., Elistratova, O., Kostyuckova, O., Islamov, R., Budyak, V., Ponomareva, E., Ullah Jan, U., Alshehri, A. M., Sedky, E., Alsihati, Z., Mimish, L., Selem, A., Malik, A., Majeed, O., Altnji, I., Alshehri, M., Aref, A., Alhabib, K., Aldosary, M., Tayel, S., Abd Alrahman, M., Asfina, K. N., Abdin Hussein, G., Butt, M., Markovic Nikolic, N., Obradovic, S., Djenic, N., Brajovic, M., Davidovic, A., Romanovic, R., Novakovic, V., Dekleva, M., Spasic, M., Dzudovic, B., Jovic, Z., Cvijanovic, D., Veljkovic, S., Ivanov, I., Cankovic, M., Jarakovic, M., Kovacevic, M., Trajkovic, M., Mitov, V., Jovic, A., Hudec, M., Gombasky, M., Sumbal, J., Bohm, A., Baranova, E., Kovar, F., Samos, M., Podoba, J., Kurray, P., Obona, T., Remenarikova, A., Kollarik, B., Verebova, D., Kardosova, G., Alusik, D., Macakova, J., Kozlej, M., Bayes-Genis, A., Sionis, A., Garcia Garcia, C., Duran Cambra, A., Labata Salvador, C., Rueda Sobella, F., Sans Rosello, J., Vila Perales, M., Oliveras Vila, T., Ferrer Massot, M., Baneras, J., Lekuona, I., Zugazabeitia, G., Fernandez-Ortiz, A., Viana Tejedor, A., Ferrera, C., Alvarez, V., DIaz-Castro, O., Agra-Bermejo, R. M., Gonzalez-Cambeiro, C., Gonzalez-Babarro, E., Domingo-Del Valle, J., Royuela, N., Burgos, V., Canteli, A., Castrillo, C., Cobo, M., Ruiz, M., Abu-Assi, E., and Garcia Acuna, J.

Subjects
Registrie, medicine.medical_specialty, medicine.medical_treatment, Cardiology, Myocardial Reperfusion, 030204 cardiovascular system & hematology, 03 medical and health sciences, Hospital, 0302 clinical medicine, Reperfusion therapy, Percutaneous Coronary Intervention, Internal medicine, Fibrinolysis, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Registries, Prospective Studies, Prospective cohort study, Observational studies, observational studies, reperfusion therapy, business.industry, Mortality rate, Primary percutaneous coronary intervention, ST-elevation myocardial infarction, Europe, Hospitals, Treatment Outcome, ST Elevation Myocardial Infarction, Percutaneous coronary intervention, medicine.disease, primary percutaneous coronary intervention, Observational studie, 3. Good health, Prospective Studie, Cohort, Conventional PCI, Cardiology and Cardiovascular Medicine, business, Human
Abstract

Aims The aim of this study was to determine the contemporary use of reperfusion therapy in the European Society of Cardiology (ESC) member and affiliated countries and adherence to ESC clinical practice guidelines in patients with ST-elevation myocardial infarction (STEMI). Methods and results Prospective cohort (EURObservational Research Programme STEMI Registry) of hospitalized STEMI patients with symptom onset Conclusions The use of reperfusion therapy for STEMI in the ESC member and affiliated countries was high. Primary PCI was the most frequently used treatment and associated total in-hospital mortality was below 5%. However, there was geographic variation in the use of primary PCI, which was associated with differences in in-hospital mortality.

Published
2021
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16. Unilateral absence of Casserio’s nerve and a communicating branch to the median nerve. An additional variant of brachial flexors motor innervation

Author

Pedrini F. A., Mariani G. A., Orsini E., Quaranta M., Ratti S., Cocco L., Manzoli L., Billi A. M., Pedrini F.A., Mariani G.A., Orsini E., Quaranta M., Ratti S., Cocco L., Manzoli L., and Billi A.M.

Subjects
body regions, Anatomical variation, Brachial plexu, Median nerve, Musculocutaneous nerve, Lateral cord
Abstract

Anomalies of the brachial plexus including the distribution of the nerves as well as its terminal branches in the upper limb have been largely described in the literature. In this case report we describe a further variant of brachial plexus formation identified during routine anatomical dissection of the right upper limb of a 62-year-old Caucasian female cadaver. On the right side no musculocutaneous nerve was identified, the median nerve was formed as expected but a short extra branch communicating between the lateral cord and the medial head of the median nerve appeared. Coracobrachialis muscle was innervated by a direct branch from the lateral cord, while biceps brachialis and brachialis muscles were reached by collaterals of the median nerve. Moreover, in the distal half of the upper limb, the median nerve contributed to the innervation of the lateral aspect of the forearm skin via the lateral cutaneous nerve of the forearm. In order to analyze this specific variant relevance we compared it with all the similar previous reported cases, trying to explain the embryological bases of the variant. The knowledge of anatomical variations of peripheral nerves is pivotal not only for surgeons, radiologists and anesthesiologists that may operate on the axilla, but also for every medical doctor to understand inexplicable clinical signs.

Published
2019

17. A scientific (c)old case at 'Luigi Cattaneo' Anatomical Wax Collection in Bologna: solving an intriguing puzzle?

Author

Orsini E., Quaranta M., Maltoni L., Zoli M., Mariani G. A., Ratti S., Leonardi L., Billi A. M., Manzoli L., and Orsini E., Quaranta M., Maltoni L., Zoli M., Mariani G.A., Ratti S., Leonardi L., Billi A.M., Manzoli L.

Subjects
prosopoectasia, anatomical wax collection, acromegaly i
Abstract

We present and discuss a late-nineteenth century clinical case described by Professor Taruffi in a scientific paper titled “Scheletro con prosopoectasia e tredici vertebre dorsali” (Skeleton with prosopoectasia and thirteen thoracic vertebrae). Taruffi could not explain the disproportionate skeletal and visceral growth, and the case could therefore be considered an unrecognized case of acromegaly. The anatomopathological specimens and the wax model cited in the paper are currently hosted at the “Luigi Cattaneo” Anatomical Wax Collection of Bologna University; however, some inaccuracies and uncertainties as to their attribution to the same case have remained to this day. The skeletal remains were examined macroscopically to investigate any structural abnormalities and pathological changes. In addition, thanks to archival, museum inventory and literature research, we documented the systematic relationship between the paper and the samples and were able to ascribe the abnormally dilated dried stomach, currently displayed in a different showcase, to the same case. This is, to our knowledge, the first case of acromegaly in the history of medical literature which also includes a visceral specimen. As far as we know, there are no reports of the occurrence of severe gastromegaly in patients with acromegaly. In view of this rare association and, to date, endocrinological research, we hypothesize a further pathogenic mechanism by which acromegaly could have induced this massive dilatation. Taruffi’s work represents an immensely valuable scientific/artistic heritage and is still cited in contemporary endocrinological literature, demonstrating its relevant contribution to the historical evolution of the disease through the nineteenth and twentieth centuries.

Published
2019

22. The ESC ACCA EAPCI EORP acute coronary syndrome ST-elevation myocardial infarction registry

Author

Zeymer, U., Ludman, P., Danchin, N., Kala, P., Maggioni, A. P., Weidinger, F, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Franz, Weidinger, Uwe, Zeymer, Nicolas, Danchin, Peter, Ludman, Peter, Sinnaeve, Petr, Kala, Roberto, Ferrari, Maggioni, Aldo P., Artan, Goda, Parounak, Zelveian, Kiril, Karamfilov, Zuzana, Motovska, Bent, Raungaard, Toomas, Marandi, Sameh Mohamed Shaheen, Rosa-Maria, Lidon, Pasi Paavo Karjalainen, Zviad, Kereselidze, Dimitrios, Alexopoulos, David, Becker, Martin, Quinn, Zaza, Iakobishvili, Hasan, Al-Farhan, Masoumeh, Sadeghi, Roberto, Caporale, Francesco, Romeo, Erkin, Mirrakhimov, Pranas, Serpytis, Andrejs, Erglis, Sasko, Kedev, Matthew Mercieca Balbi, Alice May Moore, Dariusz, Dudek, Jacek, Legutko, Jorge, Mimoso, Gabriel, Tatu-Chitoiu, Sinisa, Stojkovic, Evgeny, Shlyakhto, Khalid, F AlHabib, Matjaz, Bunc, Martin, Studencan, Mohamed Sami Mourali, Gani, Bajraktari, Marème, Konte, Florian, Larras, Elin Folkesson Lefrancq, Souad, Mekhaldi, Cécile, Laroche, Goda, A, Shuka, N, Pavli, E, Tafaj, E, Gishto, T, Dibra, A, Duka, A, Gjana, A, Kristo, A, Knuti, G, Demiraj, A, Dado, E, Hasimi, E, Simoni, L, Siqeca, M, Sisakian, H, Hayrapetyan, H, Markosyan, S, Galustyan, L, Arustamyan, N, Kzhdryan, H, Pepoyan, S, Zirkik, A, D Von Lewinski, Paetzold, S, Kienzl, I, Matyas, K, Neunteufl, T, Nikfardjam, M, Neuhold, U, Mihalcz, A, Glaser, F, Steinwender, C, Reiter, C, Grund, M, Hrncic, D, Hoppe, U, Hammerer, M, Hinterbuchner, L, Hengstenberg, C, G Delle Karth, Lang, I, Winkler, W, Hasun, M, Kastner, J, Havel, C, Derntl, M, Oberegger, G, Hajos, J, Adlbrecht, C, Publig, T, M-C, Leitgeb, Wilfing, R, Jirak, P, C-Y, Ho, Puskas, L, Schrutka, L, Spinar, J, Parenica, J, Hlinomaz, O, Fendrychova, V, Semenka, J, Sikora, J, Sitar, J, Groch, L, Rezek, M, Novak, M, Kramarikova, P, Stasek, J, Dusek, J, Zdrahal, P, Polasek, R, Karasek, J, Seiner, J, Sukova, N, Varvarovsky, I, Lazarák, T, Novotny, V, Matejka, J, Rokyta, R, Volovar, S, Belohlavek, J, Motovska, Z, Siranec, M, Kamenik, M, Kralik, R, Raungaard, B, Ravkilde, J, E Jensen, S, Villadsen, A, Villefrance, K, C Schmidt Skov, Maeng, M, Moeller, K, Hasan-Ali, H, A Ahmed, T, Hassan, M, Elguind, A, M Farouk Ismail, A Ibrahim Abd El-Aal, A El-sayed Gaafar, H Magdy Hassan, M Ahmed Shafie, M Nabil El-khouly, Bendary, A, Darwish, M, Ahmed, Y, Amin, O, Abdelhakim, A, Abosaif, K, Kandil, H, M A, G Galal, E El Hefny, E, M El Sayed, Aly, K, Mokarrab, M, Osman, M, Abdelhamid, M, Mantawy, S, R Ali, M, D Kaky, S, A Khalil, V, M E, A Saraya, Talaat, A, Nabil, M, M Mounir, W, Aransa, K. Mahmoud A., Kazamel, G, Anwar, S, Al-Habbaa, A, M Abd el Monem, Ismael, A, Amin Abu-Sheaishaa, M., M Abd Rabou, M, T M, A Hammouda, Moaaz, M, Elkhashab, K, Ragab, T, Rashwan, A, Rmdan, A, Abdelrazek, G, Ebeid, H, H Soliman Ghareeb, Farag, N, Zaki, M, Seleem, M, Torki, A, Youssef, M, A AlLah Nasser, N, Rafaat, A, Selim, H, M Makram, M, Khayyal, M, Malasi, K, Madkou, A, Kolib, M, Alkady, H, Nagah, A, Yossef, M, Wafa, A, Mahfouz, E, Faheem, G, M Magdy Moris, Ragab, A, Ghazal, M, Mabrouk, A, El-Masry, M, Naseem, M, Samir, S, Marandi, T, Reinmets, J, Allvee, M, Saar, A, Ainla, T, Vaide, A, Kisseljova, M, Pakosta, U, Eha, J, Lotamois, K, Sia, J, Myllymaki, J, Pinola, T, P Karjalainen, P, Paana, P, Mikkelsson, J, Ampio, M, Tsivilasvili, J, Zurab, P, Kereselidze, Z, Agladze, R, Melia, A, Gogoberidze, D, Khubua, N, Totladze, L, Metreveli, I, Chikovani, A, Eitel, I, Pöss, J, Werner, M, Constantz, A, Ahrens, C, Tolksdorf, H, Klinger, S, Sack, S, Heer, T, Lekakis, J, Kanakakis, I, Xenogiannis, I, Ermidou, K, Makris, N, Ntalianis, A, Katsaros, F, Revi, E, Kafkala, K, Mihelakis, E, Diakakis, G, Grammatikopoulos, K, Voutsinos, D, Alexopoulos, D, Xanthopoulou, I, Mplani, V, Foussas, S, Papakonstantinou, N, Patsourakos, N, Dimopoulos, A, Derventzis, A, Athanasiou, K, P Vassilikos, V, Papadopoulos, C, Tzikas, S, Vogiatzis, I, Datsios, A, Galitsianos, I, Koutsampasopoulos, K, Grigoriadis, S, Douras, A, Baka, N, Spathis, S, Kyrlidis, T, Hatzinikolaou, H, G Kiss, R, Becker, D, Nowotta, F, Tóth, K, Szabó, S, Lakatos, C, Jambrik, Z, Ruzsa, J, Ruzsa, Z, Róna, S, Toth, J, A Vargane Kosik, K S, B Toth, G Nagy, G, Ondrejkó, Z, Körömi, Z, Botos, B, Pourmoghadas, M, Salehi, A, Massoumi, G, Sadeghi, M, Soleimani, A, Sarrafzadegan, N, Roohafza, H, Azarm, M, Mirmohammadsadeghi, A, Rajabi, D, Rahmani, Y, Siabani, S, Najafi, F, Hamzeh, B, Karim, H, Siabani, H, Saleh, N, Charehjoo, H, Zamzam, L, Al-Temimi, T, Al-Farhan, H, Al-Yassin, A, Mohammad, A, Ridha, A, Al-Saedi, G, Atabi, N, Sabbar, O, Mahmood, S, Dakhil, Z, F Yaseen, I, Almyahi, M, Alkenzawi, H, Alkinani, T, Alyacopy, A, Kearney, P, Twomey, K, Iakobishvili, Z, Shlomo, N, Beigel, R, Caldarola, P, Rutigliano, D, L Sublimi Saponetti, Locuratolo, N, Palumbo, V, Scherillo, M, Formigli, D, Canova, P, Musumeci, G, Roncali, F, Metra, M, Lombardi, C, Visco, E, Rossi, L, Meloni, L, Montisci, R, Pippia, V, F Marchetti, M, Congia, M, Cacace, C, Luca, G, Boscarelli, G, Indolfi, C, Ambrosio, G, Mongiardo, A, Spaccarotella, C, S De Rosa, Canino, G, Critelli, C, Caporale, R, Chiappetta, D, Battista, F, Gabrielli, D, Marziali, A, Bernabò, P, Navazio, A, Guerri, E, Manca, F, Gobbi, M, Oreto, G, Andò, G, Carerj, S, Saporito, F, Cimmino, M, Rigo, F, Zuin, G, Tuccillo, B, F Scotto di Uccio, L Scotto di Uccio, Lorenzoni, G, Meloni, I, Merella, P, M Polizzi, G, Pino, R, Marzilli, M, Morrone, D, Caravelliorsini, P, Orsini, E, Mosa, S, Piovaccari, G, Santarelli, A, Cavazza, C, Romeo, F, Fedele, F, Mancone, M, Straito, M, Salvi, N, Scarparo, P, Severino, P, Razzini, C, Massaro, G, Cinque, A, Gaudio, C, Barillà, F, Torromeo, C, Porco, L, Mei, M, Lorio, R, Nassiacos, D, Barco, B, Sinagra, G, Falco, L, Priolo, L, Perkan, A, Strana, M, Bajraktari, G, Percuku, L, Berisha, G, Mziu, B, Beishenkulov, M, Abdurashidova, T, Toktosunova, A, Kaliev, K, Serpytis, P, Serpytis, R, Butkute, E, Lizaitis, M, Broslavskyte, M, G Xuereb, R, M Moore, A, M Mercieca Balbi, Paris, E, Buttigieg, L, Musial, W, Dobrzycki, S, Dubicki, A, Kazimierczyk, E, Tycinska, A, Wojakowski, W, Kalanska-Lukasik, B, Ochala, A, Wanha, W, Dworowy, S, Sielski, J, Janion, M, Janion-Sadowska, A, Dudek, D, Wojtasik-Bakalarz, J, Bryniarski, L, Z Peruga, J, Jonczyk, M, Jankowski, L, Klecha, A, Legutko, J, Michalowska, J, Brzezinski, M, Kozmik, T, Kowalczyk, T, Adamczuk, J, Maliszewski, M, Kuziemka, P, Plaza, P, Jaros, A, Pawelec, A, Sledz, J, Bartus, S, Zmuda, W, Bogusz, M, Wisnicki, M, Szastak, G, Adamczyk, M, Suska, M, Czunko, P, Opolski, G, Kochman, J, Tomaniak, M, Miernik, S, Paczwa, K, Witkowski, A, P Opolski, M, D Staruch, A, Kalarus, Z, Honisz, G, Mencel, G, Swierad, M, Podolecki, T, Marques, J, Azevedo, P, A Pereira, M, Gaspar, A, Monteiro, S, Goncalves, F, Leite, L, Mimoso, J, Manuel Lopes dos Santos, W., Amado, J, Pereira, D, Silva, B, Caires, G, Neto, M, Rodrigues, R, Correia, A, Freitas, D, Lourenco, A, Ferreira, F, Sousa, F, Portugues, J, Calvo, J, Almeida, F, Alves, M, Silva, A, Caria, R, Seixo, F, Militaru, C, Ionica, E, Tatu-Chitoiu, G, Istratoaie, O, Florescu, M, Lipnitckaia, E, Osipova, O, Konstantinov, S, Bukatov, V, Vinokur, T, Egorova, E, Nefedova, E, Levashov, S, Gorbunova, A, Redkina, M, Karaulovskaya, N, Bijieva, F, Babich, N, Smirnova, O, Filyanin, R, Eseva, S, Kutluev, A, Chlopenova, A, Shtanko, A, Kuppar, E, Shaekhmurzina, E, Ibragimova, M, Mullahmetova, M, Chepisova, M, Kuzminykh, M, Betkaraeva, M, Namitokov, A, Khasanov, N, Baleeva, L, Galeeva, Z, Magamedkerimova, F, Ivantsov, E, Tavlueva, E, Kochergina, A, Sedykh, D, Kosmachova, E, Skibitskiy, V, Porodenko, N, Litovka, K, Ulbasheva, E, Niculina, S, Petrova, M, Harkov, E, Tsybulskaya, N, Lobanova, A, Chernova, A, Kuskaeva, A, Kuskaev, A, Ruda, M, Zateyshchikov, D, Gilarov, M, Konstantinova, E, Koroleva, O, Averkova, A, Zhukova, N, Kalimullin, D, Borovkova, N, Tokareva, A, Buyanova, M, Khaisheva, L, Pirozhenko, T, Novikova, T, Yakovlev, A, Tyurina, T, Lapshin, K, Moroshkina, N, Kiseleva, M, Fedorova, S, Krylova, L, Duplyakov, D, Semenova, Y, Rusina, A, Ryabov, V, Syrkina, A, Demianov, S, Reitblat, O, Artemchuk, A, Efremova, E, Makeeva, E, Menzorov, M, Shutov, A, Klimova, N, Shevchenko, I, Elistratova, O, Kostyuckova, O, Islamov, R, Budyak, V, Ponomareva, E, U Ullah Jan, M Alshehri, A, Sedky, E, Alsihati, Z, Mimish, L, Selem, A, Malik, A, Majeed, O, Altnji, I, Alshehri, M, Aref, A, Alhabib, K, Aldosary, M, Tayel, S, M Abd AlRahman, N Asfina, K, G Abdin Hussein, Butt, M, N Markovic Nikolic, Obradovic, S, Djenic, N, Brajovic, M, Davidovic, A, Romanovic, R, Novakovic, V, Dekleva, M, Spasic, M, Dzudovic, B, Jovic, Z, Cvijanovic, D, Cvijanovic, S, Ivanov, I, Cankovic, M, Jarakovic, M, Kovacevic, M, Trajkovic, M, Mitov, V, Jovic, A, Hudec, M, Gombasky, M, Sumbal, J, Bohm, A, Baranova, E, Kovar, F, Samos, M, Podoba, J, Kurray, P, Obona, T, Remenarikova, A, Kollarik, B, Verebova, D, Kardosova, G, Studencan, M, Alusik, D, Macakova, J, Kozlej, M, Bayes-Genis, A, Sionis, A, C Garcia Garcia, R-M, Lidon, A Duran Cambra, C Labata Salvador, F Rueda Sobella, J Sans Rosello, M Vila Perales, T Oliveras Vila, M Ferrer Massot, Bañeras, J, Lekuona, I, Zugazabeitia, G, Fernandez-Ortiz, A, A Viana Tejedor, Ferrera, C, Alvarez, V, Diaz-Castro, O, M Agra-Bermejo, R, Gonzalez-Cambeiro, C, Gonzalez-Babarro, E, J Domingo-Del Valle, Royuela, N, Burgos, V, Canteli, A, Castrillo, C, Cobo, M, Ruiz, M, Abu-Assi, E, M Garcia Acuna, J, U., Zeymer, P., Ludman, N., Danchin, P., Kala, A. P., Maggioni, F., Weidinger, STEMI Investigators, Ac, and Spaccarotella, C.

Subjects
Registrie, medicine.medical_specialty, Acute coronary syndrome, Registry, medicine.medical_treatment, Cardiology, Reperfusion therapy, Retrospective Studie, Medical, medicine, Humans, cardiovascular diseases, Myocardial infarction, Registries, Disease management (health), Acute Coronary Syndrome, Societies, Medical, Quality of Health Care, Retrospective Studies, Acca, biology, business.industry, Health Policy, Primary percutaneous coronary intervention, Percutaneous coronary intervention, Disease Management, Retrospective cohort study, medicine.disease, biology.organism_classification, primary percutaneous coronary intervention, registry, reperfusion therapy, ST-elevation myocardial infarction, Cardiac surgery, Europe, surgical procedures, operative, Emergency medicine, ST Elevation Myocardial Infarction, Societies, Cardiology and Cardiovascular Medicine, business, Human
Abstract

Aims The Acute Cardiac Care Association (ACCA)–European Association of Percutaneous Coronary Intervention (EAPCI) Registry on ST-elevation myocardial infarction (STEMI) of the EurObservational programme (EORP) of the European Society of Cardiology (ESC) registry aimed to determine the current state of the use of reperfusion therapy in ESC member and ESC affiliated countries and the adherence to ESC STEMI guidelines in patients with STEMI. Methods and results Between 1 January 2015 and 31 March 2018, a total of 11 462 patients admitted with an initial diagnosis of STEMI according to the 2012 ESC STEMI guidelines were enrolled. Individual patient data were collected across 196 centres and 29 countries. Among the centres, there were 136 percutaneous coronary intervention centres and 91 with cardiac surgery on-site. The majority of centres (129/196) were part of a STEMI network. The main objective of this study was to describe the demographic, clinical, and angiographic characteristics of patients with STEMI. Other objectives include to assess management patterns and in particular the current use of reperfusion therapies and to evaluate how recommendations of most recent STEMI European guidelines regarding reperfusion therapies and adjunctive pharmacological and non-pharmacological treatments are adopted in clinical practice and how their application can impact on patients’ outcomes. Patients will be followed for 1 year after admission. Conclusion The ESC ACCA-EAPCI EORP ACS STEMI registry is an international registry of care and outcomes of patients hospitalized with STEMI. It will provide insights into the contemporary patient profile, management patterns, and 1-year outcome of patients with STEMI.

Published
2019

24. Immunology

Author

Shahi, C. N., Fou, X. J., Chua, A., McDevitt, T., O’Connell, M., Weir, D. G., Keeling, P. W. N., Kelleher, D., Crabtree, J. E., Lindley, I. J. D., Trejdosiewicz, L. K., Peichl, P., Wyatt, J.I, Figura, N., Tomkins, D. S., Bughol, M., Wyatt, J. I., Sobala, G. M., Primioc, J. N., Weigert, N., Stolley, S., Schusdziarra, V., Classen, M., Schepp, W., Kuipers, E. J., Gracia-Casanova, M., Pena, A. S., Crusius, J. B. A., Defize, J., van Kamp, G., Meuwissen, S. G. M., Pals, G., Ryan, E., Mac Mathuna, P., Kelly, P., Lennon, J., Crowe, J., Lynch, D. A. F., Mapstoe, N. M., Lewis, F., Hassan, F., Axon, A. T. R., Dixon, M. F., Quirke, P. E., Karttunen, R., Karttunen, T., Kerola, T., Niemlä, S., Kosunen, T. U., De Magistris, M. T., Nuti, S., Tommaso, A. Di, Figura, N., Bayel, P. F., Penhatini, C., Bugnoli, M., Rappuoli, R., Abrignani, S., Atherton, J. C., Hudson, N., Hale, T. L., Kirk, G. E., Spiller, R. C., Hawkey, C. J., Noach, L. A., Bosma, N. B., Jansen, J., Ceska, M., Tytgat, G. N. J., Deventer, S. J. H. van, Tulliez, M., Guerre, J., Orsini, E., Chaussade, S., Gaudric, M., Willemse, P. J. A., de Maat, M. P. M., Godfroy, F. J. M., Knot, E. A. R., Blankenstein, M.van, Wilson, J. H. P., Fan, X. J., and Keeling, P. W. N.

Published
1992
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25. Pathology

Author

Aruin, L. I., Sarkisov, D. S., Lisenco, O. A., O’Connor, H., Cunnane, K., Queiroz, D. M. M., Mendes, E. N., Rocha, G. A., Moura, S. B., Resende, L. M. H., Cunha-Melo, J. R., Carvalho, A. S. T., Coelho, L. G. V., Passos, M. C. G., Castro, L. P., Oliveira, C. A., Lima, G. F., Barbosa, A. J. A., Passos, M. C. F., Castro, P., Testino, Gianni, Perasso, A., Boixeda, D., de Argila, C. Martín, Vila, T., Redondo, C., Cantón, R., Avila, C., Alvarez-Baleriola, I., de Rafael, L., Witteman, E. M., Becx, M. C. J. M., De Koning, R. W., Silva, J. C. P., Nogueira, A. M. M. F., Paulino, E., Miranda, C. R., Rudelli, A., Vialette, G., Sevestre, H., Capron, D., Ducroix, J. P., Smail, A., Baillet, J., Zerbib, F., Seurat, P. L., Sauvet, P., Bechade, D., Rapp, N., Peacock, J. S., Marchildon, P., Zamaniyan, F., Bond-Green, J., Liu, P., Ciota, L., Lee, A., Coltro, N., Chen, M., Alhomsi, M., Adeyemi, E., Goodwin, C. S., Rizzi, C., Maieron, R., Desinan, L., Avellini, C., Da Broi, G. L., Beltrami, C. A., Proto, G., Grimaldi, F., Proietti, A., Scott, C. A., Takasashi, S., Igarshi, H., Ishiyama, N., Nakamura, K., Masubuchi, N., Ozaki, M., Saito, S., Aoyagi, T., Itoh, T., Hirata, I., Matysiak-Budnik, T., Poniewierka, E., Gasciniak, G., Jelen, M., Knapik, Z., Gosciniak, G., Neri, W. M., Susi, D., Bovani, I., Laterza, F., Cuccurullo, F., Amorosi, A., Bechi, P., Dei, R., Mazzanti, R., Lynch, D. A. F., Sobala, G. M., Gledhill, A., Jackson, P., Crabtree, J. E., Foster, P. N., Axon, A. T. R., Dixon, M. F., Maaroos, H. I., Sipponen, P., Kekki, M., Di Bello, M. G., Raspanti, S., Vardar, T., Sancho F. J., Olivia E., Saiz S., Mones J. Pons, Hood, Craig, Lesna, Milena, Alcolado, Ruth, Knitht, T., Greaves, S., Wilson, A., Corlett, M., Webb, P., Wyatt, J., Newell, D., Hengels, K., Forman, D., Elder, J. B., Farinati, F., Cardin, R., Valiante, F., Libera, G. Delia, Plebani, M., Rugge, M., Baffa, R., Guido, M., Mario, F. Di, Naccarato, R., Gilvarry, J., Leen, E., Sant, S., Sweeney, E., Morain, C. O’, Schönlebe, J., Riedel, H., Prinz, M., Hahn, L., Porst, H., Lohmann, H., Orsini, E., Guerre, J., Tulliez, M., Chaussade, S., Gaudric, M., Canton, R., Sampedro, J., García-Plaza, A., Cognein, P., Parodi, M. C., Tucci, A., Gasperoni, S., Stanghellini, V., Tosetti, C., Paparo, G. F., Varoli, O., Siringo, S., Santucci, R., Monetti, N., Barbara, G., Corinaldesi, R., Di Mario, F., Dotto, P., Vianello, F., M. Ferrana, Grasso, G. A., Bianco, T. Del, Laino, G., Germanà, B., Battaglia, G, Axelson, C. K., Andersen, L. P., Szecsi, P. B., Olsen, K. N., Lundborg, C. J., Andre, C., Descos, L., Martin, A., Cavagna, S., Brassens-Rabbé, M P., Wu, S., Wadström, T., Mégraud, F., Perdichizzi, G., Muratori, L., Pallio, S., Bottair, M., T. Fera, M., Quattrocchi, E., Caruso, V., Karttunen, T., Kerola, T., Kartttunen, R., Niemelä, S., Kosunen, T. U., Bonchviam, F., Pretolani, S., Baraldine, M., Cilla, D., Baldinelli, S., and Gasparrini, G.

Published
1992
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27. Estimating liver function in a large cirrhotic cohort: Signal intensity of gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI

Author

Ippolito, D, Famularo, S, Giani, A, Orsini, E, Pecorelli, A, Pinotti, E, Gandola, D, Romano, F, Sironi, S, Bernasconi, D, Gianotti, L, Orsini, EB, GANDOLA, DAVIDE GIACOMO, Bernasconi, DP, Ippolito, D, Famularo, S, Giani, A, Orsini, E, Pecorelli, A, Pinotti, E, Gandola, D, Romano, F, Sironi, S, Bernasconi, D, Gianotti, L, Orsini, EB, GANDOLA, DAVIDE GIACOMO, and Bernasconi, DP

Abstract

Background: To assess whether gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI study is useful to estimate liver function in comparison to the presence or absence of cirrhosis, Child Pugh (CP), Model for End-stage Liver Disease (MELD), ALBI scores and biochemical test. Methods: We retrospectively reviewed all consecutive Gd-EOB-DTPA-enhanced-MRI studies performed between 2010 and 2016 in patients with focal liver lesions undergoing clinical evaluation. Patients were divided in study and control group according to the presence of cirrhosis, and then classified by CP, MELD and ALBI. Signal intensity was calculated through the liver-to-muscle ratio in portal- (SI-POR) and hepatobiliary-phase(SI-HEP). Results: Three-hundred-three Gd-EOB-DTPA liver-enhanced-MRI studies were included. One-hundred-ninety-one patients (63%) were cirrhotic. SI-HEP was significantly lower in cirrhotic group (0.55 ± 0.29 vs 0.66 ± 0.40, p = 0.004).The SI-HEP progressively decreased from CP-A to CP-C (0.59 ± 0.28 to 0.25 ± 0.19, p < 0.0001) and a significant difference was found between MELD ≤ 9 and MELD > 9 groups (0.61 ± 0.31 vs 0.49 ± 0.28, p = 0.007). No differences between ALBI grades were evident. Among biochemical parameters a moderate correlation was found among SI-HEP and total bilirubin, AST and albumin. Conclusion: SI-HEP after Gd-EOB-DTPA-enhanced-MRI effectively stratified patients with different Child Pugh grades and MELD scores. This technique could hence be useful as a novel radiological marker to estimate the underlying liver function.

Published
2019

28. Assessing liver function: diagnostic efficacy of parenchymal enhancement and liver volume ratio of Gd-EOB-DTPA-enhanced MRI study during interstitial and hepatobiliary phase

Author

Ippolito, D, Pecorelli, A, Famularo, S, Bernasconi, D, Orsini, E, Giani, A, Romano, F, Talei Franzesi, C, Sironi, S, Ippolito, Davide, Pecorelli, Anna, Famularo, Simone, Bernasconi, Davide, Orsini, Eleonora Benedetta, Giani, Alessandro, Romano, Fabrizio, Talei Franzesi, Cammillo, Sironi, Sandro, Ippolito, D, Pecorelli, A, Famularo, S, Bernasconi, D, Orsini, E, Giani, A, Romano, F, Talei Franzesi, C, Sironi, S, Ippolito, Davide, Pecorelli, Anna, Famularo, Simone, Bernasconi, Davide, Orsini, Eleonora Benedetta, Giani, Alessandro, Romano, Fabrizio, Talei Franzesi, Cammillo, and Sironi, Sandro

Abstract

Aim: To assess the efficacy of signal intensity in interstitial and hepatobiliary phase normalized for liver volume, on gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) study, for the evaluation of liver function through the comparison with Child–Pugh (CP), model for end-stage liver disease (MELD), and biochemical tests. Methods: All dynamic Gd-EOB-DTPA MRI studies performed in patients with suspected liver lesions were retrospectively reviewed. The rate of liver-to-muscle ratio on T1 sequence 70 s (interstitial phase) and 20 min (hepatobiliary phase) after injection of Gd-EOB-DTPA was calculated for each MRI study and then normalized for liver volume (irINTnorm and irHEPnorm). Pearson correlation coefficient was computed to assess the correlation among these values and CP and MELD scores, and biochemical tests. Results: A total of 303 MRI studies, performed on 221 patients, were included. Mean age was 63.8 years ± 12.9 with a majority of male patients (186; 61.4%). A total of 186 out of 303 (61.4%) were cirrhotic patients. The irHEPnorm was significantly lower in cirrhotic than non-cirrhotic patients (0.0004 ± 0.0002 to 0.0005 ± 0.0003, p = 0.010). This value had a moderate, significant correlation with Child–Pugh and MELD scores (R = − 0.292, p < 0.0001 and R = − 0.192, p = 0.010, respectively). In particular, irHEPnorm progressively decreased from Child–Pugh A to C (0.0004–0.0002, p < 0.0001) and from MELD ≤ 10 to 19–24 (0.0004–0.0003, p = 0.018). Among biochemical parameters, total bilirubin, GOT, and albumin had the strongest correlation with irHEPnorm (R = − 0.258, − 0.291, and 0.262, p < 0.0001, respectively). No correlations were found between irINTnorm and CP and MELD scores. Conclusion: irHEPnorm value derived from Gd-EOB-DTPA-enhanced MRI is a reliable, non-invasive, useful tool to quantify liver function and to assess the degree of cirrhosis, offering a strict relationship with clinical sc

Published
2019

31. A COMBINATION OF BORTEZOMIB WITH CX-4945, A CASEIN KINASE 2 (CK2) INHIBITOR, HAS SYNERGISTIC CYTOTOXIC EFFECTS IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) CELL LINES

Author

BUONTEMPO, FRANCESCA, Orsini E, Cappellini A, LONETTI, ANNALISA, EVANGELISTI, CECILIA, Chiarini F, Spartà AM, Bressanin D, Evangelisti C, Martelli AM, Buontempo, Francesca, Orsini, E, Cappellini, Alessandra, Lonetti, Annalisa, Evangelisti, C, Chiarini, Francesca, Spartà, Am, Bressanin, D, Martelli, Am, Buontempo F, Orsini E, Cappellini A, Lonetti A, Evangelisti C, Chiarini F, Spartà AM, Bressanin D, and Martelli AM

Subjects
ACUTE LYMPHOBLASTIC LEUKEMIA (ALL), hemic and lymphatic diseases, CK2
Abstract

Introduction. The proteasome inhibitor bortezomib is a new treatment option for patients with refractory or relapsed ALL, particularly when used in combination with conventional chemotherapy or other targeted agents. Indeed, a limited efficacy of bortezomib alone in ALL patients has been reported. A terminal pro-apoptotic endoplasmic reticulum (ER) stress/unfolded protein response (UPR) is one of the several mechanisms of bortezomib-induced apoptosis. CX-4945, a potent CK2 inhibitor, has been found to induce apoptotic cell death in T-ALL preclinical models, via perturbation of ER/UPR pathway. Here, we have explored the cytotoxic effects of a bortezomib/CX-4945 combination in a panel of B- and T-ALL cell lines. Methods. B- (KOPN-8, NALM-6, RS4;11) and T- (MOLT-4, Jurkat, CEM-R) ALL cell lines were pretreated with bortezomib (Selleck Chemicals, Houston TX, USA), for six hours and then with CX-4945 (Selleck Chemicals, Houston TX, USA), for 16/24 hours. MTT assays were performed to analyze cell viability. Apoptosis induction was evaluated by Annexin V/PI staining and flow cytometric analysis. Protein expression was studied by western blot. Results. Cells were cultured in the presence of bortezomib or CX-4945, either alone or in combination at a fixed ratio. The combined treatment was more effective in reducing cell viability in all B-ALL cell lines and in MOLT-4 cells. Annexin V/PI staining was performed; interestingly, no synergism was detected if the two drugs were administered together since the beginning of treatment. In response to treatment with 2.5 nM bortezomib followed by 5 μM CX-4945, we detected an increase in apoptosis in B-ALL cell lines and in MOLT-4 cells after 24 h. Western blot analysis for the cleaved forms of caspase-3 and PARP, confirmed a higher apoptosis induction by the combined treatment. A reduction in anti-apoptotic Bcl2 concomitant with an increase in proapoptotic Bax, suggested that bortezomib/CX-4945 treatment caused a mitochondrial apoptosis. IRE1a and CHOP (established markers of ER stress/UPR-mediated apoptosis) levels increased in response to the combined treatment, in contrast the expression of GRP78/BIP (a marker of UPR activation) decreased, suggesting that a potential mechanism by which the drug combination induced cell death, involved ER stress induction by bortezomib and the inability to respond by adequate activation of the UPR signaling which was blocked by CX-4945. Conclusions. Here, we demonstrated that the proteasome inhibitor bortezomib and the CK2 inhibitor CX-4945 interact in a synergistic manner to induce apoptosis both in B- and in T-ALL cell lines. Drug cytotoxicity was associated with modulation of the ER stress/UPR signaling pathway. Importantly, the synergism was observed only when bortezomib treatment preceded CX-4945 administration. Therefore, our findings support clinical application of bortezomib in combination with CX- 4945 in B- and T-ALL treatment.

Published
2014

32. Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

Author

Evangelisti, C., Cappellini, A., Oliveira, M., Fragoso, R., Barata, J. T., Bertaina, A., Locatelli, Franco, Simioni, C., Neri, L. M., Chiarini, F., Lonetti, A., Buontempo, F., Orsini, E., Pession, A., Manzoli, L., Martelli, A. M., Locatelli F. (ORCID:0000-0002-7976-3654), Evangelisti, C., Cappellini, A., Oliveira, M., Fragoso, R., Barata, J. T., Bertaina, A., Locatelli, Franco, Simioni, C., Neri, L. M., Chiarini, F., Lonetti, A., Buontempo, F., Orsini, E., Pession, A., Manzoli, L., Martelli, A. M., and Locatelli F. (ORCID:0000-0002-7976-3654)

Published
2018

33. Dynamic contrast enhanced perfusion CT imaging: A diagnostic biomarker tool for survival prediction of tumour response to antiangiogenetic treatment in patients with advanced HCC lesions

Author

Ippolito, D, Querques, G, Okolicsanyi, S, Talei Franzesi, C, Pecorelli, A, Lombardi, S, Orsini, E, Strazzabosco, M, Sironi, S, Ippolito, Davide, Querques, Giulia, Okolicsanyi, Stefano, Talei Franzesi, Cammillo, PECORELLI, ANNA, LOMBARDI, SOPHIE, ORSINI, ELEONORA BENEDETTA, Strazzabosco, Mario, Sironi, Sandro, Ippolito, D, Querques, G, Okolicsanyi, S, Talei Franzesi, C, Pecorelli, A, Lombardi, S, Orsini, E, Strazzabosco, M, Sironi, S, Ippolito, Davide, Querques, Giulia, Okolicsanyi, Stefano, Talei Franzesi, Cammillo, PECORELLI, ANNA, LOMBARDI, SOPHIE, ORSINI, ELEONORA BENEDETTA, Strazzabosco, Mario, and Sironi, Sandro

Abstract

Purpose: To investigate whether perfusion-CT (p-CT) imaging could depict the inhibition of tumor neoangiogenesis induced by Sorafenib in advanced hepatocellular carcinoma (HCC), and whether it could be useful in predicting survival during treatment. Materials and methods: Ninety-eight p-CT examinations were performed among 29 cirrhotic patients, with advanced HCC, before and every 2 months after Sorafenib administration, on a 256-slice MDCT scanner. Perfusion parameters were considered and statistically compared, at baseline and follow-up, between non-progressor (complete response, stable disease or partial response) and progressor (progressive disease) group. Kaplan-Meier analyses estimated the time-to-survival in overall population, after stratifying patients according to mRECIST. Results: The group that responded to Sorafenib showed a significant reduction of values in HCC target lesions after anti-angiogenic therapy (p < 0.01), in comparison with progressor group that demonstrated an increase or no significant variation. When patients were stratified into mRECIST, higher survival rate was observed in the non-progressor group compared to the progressor (48.6% vs 28.6%), and statistically significant correlation (p=0.01) was found between percentage variation of perfusion parameters, from baseline to follow-up, and overall survival rate. Conclusion: Quantitative analysis of perfusion parameters, represents prognostic indicators useful in assessment of response to anti-angiogenic therapy, allowing for optimization of individualized treatment.

Published
2018

34. INHIBITION OF PROLIFERATION AND SURVIVAL IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL) CELLS REQUIRES BLOCKADE OF ALL THE CLASS I PI3Ks ISOFORMS

Author

LONETTI, ANNALISA, CAPPELLINI, ALESSANDRA, BUONTEMPO, FRANCESCA, EVANGELISTI, CECILIA, Spartà AM, Bressanin D, Chiarini F, Evangelisti C, Orsini E, Martelli AM, Lonetti A, Cappellini A, Spartà AM, Bressanin D, Buontempo F, Chiarini F, Evangelisti C, Orsini E, and Martelli AM

Subjects
T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL), PI3K
Abstract

Introduction. The heterodimeric class I phosphatidylinositol 3-kinases (PI3Ks) regulate a variety of cellular processes including cell proliferation, survival and metabolism, by generating the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3). PI3Ks are widely implicated in human cancers and in particular are upregulated in T-ALL, mainly due to the impairment of the lipid phosphatase PTEN function. At present different compounds which target single or multiple PI3K catalytic subunits have entered clinical trials. Here we have explored the role of the different PI3K isoforms in T-ALL in order to identify the most effective targeted therapy strategy. Methods. Both PTEN wt (ALLSIL and DND-41) and PTEN deleted (Jurkat and Loucy) T-ALL cell lines were treated with class I pan-PI3K inhibitors (BKM120 and ZSTK454) or p110α (A-66), p110b (TGX-221), p110g (AS-605240), p110δ (CAL- 101) and p110g/δ (IPI-145) selective inhibitors (Selleck Chemicals, Houston TX, USA), and their effects were evaluated. Results. In all the tested cell lines, flow cytometric analysis evidenced a reduction in PIP3 levels after all treatments, documenting PI3K inhibition. However, the extent of PIP3 reduction varied in the different cell lines and did not correlate to drug cytotoxicity. Indeed, only pan-PI3K inhibition significantly affected cell viability and proliferation in a dose- and time-dependent manner, with IC50 values ranging between 1 and 3.4 μM, for both BKM120 and ZSTK454, whereas for all the other drugs IC50 values were not attained. These findings suggested that antiproliferative effects are not exclusively dependent on PIP3 reduction. Moreover, only Loucy cell line resulted sensitive to the p110g and g/δ inhibitors, suggesting that a more complex cellular background might influence cytotoxicity. Consistent with these results, Annexin V/PI staining analysis showed an increase of apoptosis after 48h treatment in both PTEN wt and deleted cell lines only after treatment with pan-PI3K inhibitors, whereas cell cycle progression was not affected. PI3K signaling pathway analysis revealed the complete inactivation of the downstream Akt pathway almost exclusively after treatment with pan-PI3K inhibitors, as evidenced by decrease of p-Akt, both at Thr308 and Ser473, p- P70S6K and p-S6RP. Of note, p110g and p110δ inhibition slightly affected these PI3K targets, but only in some cell lines. Furthermore, PI3K inhibition did not affect activity of PDK1 and PKC proteins. Overall, no differences emerged related to PTEN status. Conclusions. Here we demonstrated that, irrespective of PTEN status, only pan-class I PI3K inhibition is cytotoxic in T-ALL cells, implying that any isoform could sustain leukemic cell survival, and suggesting a redundant role played by each isoform. Therefore, our findings strongly support clinical application of pan-class I PI3K rather than single-isoform inhibitors in TALL treatment.

Published
2014

36. EVALUATION OF THE EFFICACY AND ANTITUMOR ACTIVITY OF THE PAN-CLASS I PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITOR NVP-BKM120 IN HUMAN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL)

Author

LONETTI, ANNALISA, Chiarini F, Antunes I, Orsini E, Melchionda F, Iacobucci I, Barata JT, Martelli AM, BUONTEMPO, FRANCESCA, Lonetti A, Chiarini F, Antunes I, Orsini E, Buontempo F, Melchionda F, Iacobucci I, Barata JT, and Martelli AM

Subjects
PI3K/AKT, T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL), NV-BM120
Abstract

Introduction. T-ALL is an aggressive malignancy and despite improvements in survival rates prognosis is still poor. A common aberrantly expressed pathway related to T-ALL and converging on anti-apoptotic and pro-survival signals activation is PI3K/Akt and its inhibition is an attractive strategy to improve current treatments. NVP-BKM120 is a highly selective pan-class I PI3K inhibitor which has shown antitumor activity in preclinical and clinical studies in solid cancers. Here we investigated its efficacy in T-ALL. Methods. A panel of T-ALL cell lines with up-regulated PI3K/Akt signaling and primary T-ALL blasts were treated with increasing concentrations of NVP-BKM120 and analyzed at different time points. Results. MTT assays documented a strong reduction of viability in all cell lines tested with a median IC50 lower than 2μM after 48 hours treatment that correlate with apoptosis as documented by Annexin V/PI analysis and activatation of caspases. To asses selective inhibition of PI3K, levels of the pathway components p-Akt(ser473) and p-S6RP(Ser235/236) have been evaluated by western blotting showing a strong decrease in a dose and time dependent manner. Efficacy of NVP-BKM120 was also tested in an ex-vivo model of primary blasts from T-ALL patients with assessed constitutive activation of PI3K/Akt pathway and results were consistent with in vitro studies. Comparison between NVP-BKM120 and PI3K selective inhibitors p110 isoforms provided its stronger effect in terms of viability and pathway inhibition. The drug was also able to synergize with dexamethasone and vincristine both in vitro and ex-vivo. To note, NVP-BKM120 extents pro-apoptotic effects also in Jurkat cells co-cultured with MS-5 stromal cells which mimic bone marrow microenvironment suggesting a potential overcome of its protective effect toward leukemic cells in vivo. Finally cell cycle has been analyzed by flow cytometry revealing a strong accumulation in the G2/M phase while immunofluorescent analysis identified an increased number of mitotic cells with disorganized mitotic spindle compared to control, suggesting an impairment in G2/M regulation and in mechanisms involved in cell cycle progression. Conclusion: NVPBKM120 showed viability reduction and apoptosis induction in T-ALL cells as well as in primary T-ALL blasts due to PI3K pathway inhibition supporting its clinical evaluation in T-ALL.

Published
2013

39. Charged-particle multiplicities in pp interactions at root s=900 GeV measured with the ATLAS detector at the LHC ATLAS Collaboration

Author

Aad, G, Abat, E, Abbott, B, Abdallah, J, Abdelalim, A, Abdesselam, A, Abdinov, O, Abi, B, Abolins, M, Abramowicz, H, Abreu, H, Acerbi, E, Acharya, B, Ackers, M, Adams, D, Addy, T, Adelman, J, Aderholz, M, Adorisio, C, Adragna, P, Adye, T, Aefsky, S, Aguilar Saavedra, J, Aharrouche, M, Ahlen, S, Ahles, F, Ahmad, A, Ahmed, H, Ahsan, M, Aielli, G, Akdogan, T, Akesson, P, Akesson, T, Akimoto, G, Akimov, A, Aktas, A, Alam, M, Albert, J, Albrand, S, Aleksa, M, Aleksandrov, I, Aleppo, M, Alessandria, F, Alexa, C, Alexander, G, Alexandre, G, Alexopoulos, T, Alhroob, M, Aliev, M, Alimonti, G, Alison, J, Aliyev, M, Allport, P, Allwood Spiers, S, Almond, J, Aloisio, A, Alon, R, Alonso, A, Alonso, J, Alviggi, M, Amako, K, Amaral, P, Ambrosini, G, Ambrosio, G, Amelung, C, Ammosov, V, Amorim, A, Amoros, G, Amram, N, Anastopoulos, C, Andeen, T, Anders, C, Anderson, K, Andreazza, A, Andrei, V, Andrieux, M, Anduaga, X, Angerami, A, Anghinolfi, F, Anjos, N, Annovi, A, Antonaki, A, Antonelli, M, Arai, Y, Arce, A, Archambault, J, Arfaoui, S, Arguin, J, Argyropoulos, T, Arik, E, Arik, M, Armbruster, A, Arms, K, Armstrong, S, Arnaez, O, Arnault, C, Artamonov, A, Arutinov, D, Asai, M, Asfandiyarov, R, Ask, S, Asman, B, Asner, D, Asquith, L, Assamagan, K, Astbury, A, Astvatsatourov, A, Athar, B, Atoian, G, Aubert, B, Auerbach, B, Auge, E, Augsten, K, Aurousseau, M, Austin, N, Avolio, G, Avramidou, R, Axen, D, Ay, C, Azuelos, G, Azuma, Y, Baak, M, Baccaglioni, G, Bacci, C, Bach, A, Bachacou, H, Bachas, K, Bachy, G, Backes, M, Badescu, E, Bagnaia, P, Bai, Y, Bailey, D, Bain, T, Baines, J, Baker, O, Baker, M, Baker, S, Pedrosa, F, Banas, E, Banerjee, P, Banerjee, S, Banfi, D, Bangert, A, Bansal, V, Baranov, S, Barashkou, A, Barber, T, Barberio, E, Barberis, D, Barbero, M, Bardin, D, Barillari, T, Barisonzi, M, Barklow, T, Barlow, N, Barnett, B, Barnett, R, Baroncelli, A, Barone, M, Barr, A, Barreiro, F, Null, C, Barrillon, P, Bartheld, V, Bartko, H, Bartoldus, R, Bartsch, D, Bates, R, Bathe, S, Batkova, L, Batley, J, Battaglia, A, Battistin, M, Battistoni, G, Bauer, F, Bawa, H, Bazalova, M, Beare, B, Beau, T, Beauchemin, P, Beccherle, R, Becerici, N, Bechtle, R, Beck, G, Beck, H, Beckingham, M, Becks, K, Beddall, A, Bednyakov, V, Bee, C, Begel, M, Harpaz, S, Behera, P, Beimforde, M, Belanger, G, Belanger Champagne, C, Belhorma, B, Bell, P, Bell, W, Bella, G, Bellagambala, L, Bellina, F, Bellomo, G, Bellomo, M, Belloni, A, Belotskiy, K, Beltramello, O, Belymam, A, Ben Ami, S, Benary, O, Benchekroun, D, Benchouk, C, Bendel, M, Benedict, B, Benekos, N, Benhammou, Y, Benincasa, G, Benjamin, D, Benoit, M, Bensinger, J, Benslama, K, Bentvelsen, S, Beretta, M, Berge, D, Kuutmann, E, Berger, N, Berghaus, F, Berglund, E, Beringer, J, Bernardet, K, Bernat, P, Bernhard, R, Bernius, C, Berry, T, Bertin, A, Bertinelli, F, Bertolucci, S, Besana, M, Besson, N, Bethke, S, Bianchi, R, Bianco, M, Biebel, O, Bieri, M, Biesiada, J, Biglietti, M, Bilokon, H, Binder, M, Bindi, M, Binet, S, Bingul, A, Bini, C, Biscarat, C, Bischof, R, Bitenc, U, Black, K, Blair, R, Blanch, O, Blanchard, J, Blanchot, G, Blocker, C, Blocki, J, Blondel, A, Blum, W, Blumenschein, U, Boaretto, C, Bobbink, G, Bocci, A, Bocian, D, Bock, R, Boehler, M, Boehm, M, Boek, J, Boelaert, N, Boser, S, Bogaerts, J, Bogouch, A, Bohm, C, Bohm, J, Boisvert, V, Bold, T, Boldea, V, Boldyrev, A, Bondarenko, V, Bondioli, M, Bonino, R, Boonekamp, M, Boorman, G, Boosten, M, Booth, C, Booth, P, Booth, J, Bordoni, S, Borer, C, Borer, K, Borisov, A, Borissov, G, Borjanovic, I, Borroni, S, Bos, K, Boscherini, D, Bosman, M, Boterenbrood, H, Botterill, D, Bouchami, J, Boudreau, J, Bouhova Thacker, E, Boulahouache, C, Bourdarios, C, Boveia, A, Boyd, J, Boyer, B, Boyko, I, Bozhko, N, Bozovic Jelisavcic, I, Braccini, S, Bracinik, J, Braem, A, Brambilla, E, Branchini, P, Brandenburg, G, Brandt, A, Brandt, G, Brandt, O, Bratzler, U, Brau, B, Brau, J, Braun, H, Bravo, S, Brelier, B, Bremer, J, Brenner, R, Bressler, S, Breton, D, Brett, N, Bright Thomas, P, Britton, D, Brochu, F, Brock, I, Brock, R, Brodbeck, T, Brodet, E, Broggi, E, Bromberg, C, Brooijmans, G, Brooks, W, Brown, G, Brubaker, E, Null, R, Bruncko, D, Bruneliere, R, Brunet, S, Bruni, A, Bruni, G, Bruschi, M, Buanes, T, Bucci, E, Buchanan, J, Buchanan, N, Buchholz, R, Buckley, A, Budagov, I, Budick, B, Buscher, V, Bugge, L, Buira Clark, D, Buis, E, Bujor, E, Bulekov, O, Bunse, M, Buran, T, Burckhart, H, Burdin, S, Burgess, T, Burke, S, Busato, E, Bussey, R, Buszello, C, Butin, E, Butler, B, Butler, J, Buttar, C, Butterworth, J, Byatt, T, Caballero, J, Urban, S, Caccia, M, Caforio, D, Cakir, O, Calafiura, P, Calderini, G, Calfayan, P, Calkins, R, Caloba, L, Caloi, R, Calvet, D, Camard, A, Camarri, P, Cambiaghi, M, Cameron, D, Cammin, J, Campana, S, Campanelli, M, Canale, V, Canelli, F, Canepa, A, Cantero, J, Capasso, L, Garrido, M, Caprini, I, Caprini, M, Caprio, M, Capua, M, Caputo, R, Caramarcu, C, Cardarelli, R, Sas, L, Carli, T, Carlino, G, Carminati, L, Caron, B, Caron, S, Carpentieri, C, Montoya, G, Montero, S, Carter, A, Carter, J, Carvalho, J, Casadei, D, Casado, M, Cascella, M, Cas, C, Hernadez, A, Castaneda Miranda, E, Gimenez, V, Castro, N, Castrovillari, F, Cataldi, G, Cataneo, F, Catinaccio, A, Catmore, J, Cattai, A, Cattani, G, Caughron, S, Cauz, D, Cavallari, A, Cavalleri, P, Cavalli, D, Cavalli Sforza, M, Cavasinni, V, Cazzato, A, Ceradini, E, Cerna, C, Cerqueira, A, Cerri, A, Cerrito, L, Cerutti, F, Cervetto, M, Cetin, S, Cevenini, E, Chafaq, A, Chakraborty, D, Chan, K, Chapman, J, Chareyre, E, Charlton, D, Charron, S, Chatterjii, S, Chavda, V, Cheatham, S, Chekanov, S, Chekulaev, S, Chelkov, G, Chen, H, Chen, L, Chen, S, Chen, T, Chen, X, Cheng, S, Cheplakov, A, Chepurnov, V, El Moursli, R, Tcherniatine, V, Chesneanu, D, Cheu, E, Cheung, S, Chevalier, L, Chevallier, F, Chiarella, V, Chiefari, G, Chikovani, L, Childers, J, Chilingarov, A, Chiodini, G, Chizhov, V, Choudalakis, G, Chouridou, S, Christiansen, T, Christidi, I, Christov, A, Chromek Burckhart, D, Chu, M, Chudoba, J, Ciapetti, G, Cicalini, E, Ciftci, A, Ciftci, R, Cinca, D, Cindro, V, Ciobotaru, M, Ciocca, C, Ciocio, A, Cirilli, M, Citterio, M, Clark, A, Clark, P, Cleland, W, Clemens, J, Clement, B, Clement, C, Clements, D, Clifft, R, Coadou, Y, Cobal, M, Coccaro, A, Cochran, J, Coco, R, Coe, R, Coelli, S, Coggeshall, J, Cogneras, E, Cojocaru, C, Colas, J, Cole, B, Colijn, A, Collard, C, Collins, N, Collins Tooth, C, Collot, J, Colon, G, Coluccia, R, Comune, G, Muino, P, Coniavitis, E, Consonni, M, Constantinescu, S, Conta, C, Conventi, F, Cook, J, Cooke, M, Cooper, B, Cooper Sarkar, A, Cooper Smith, N, Copic, K, Cornelissen, T, Corradi, M, Correard, S, Corriveau, F, Corso Radu, A, Cortes Gonzalez, A, Cortiana, G, Costa, G, Costa, M, Costanzo, D, Costin, T, Cote, D, Torres, R, Courneyea, L, Couyoumtzelis, C, Cowan, G, Cowden, C, Cox, B, Cranmer, K, Cranshaw, J, Cristinziani, M, Crosetti, G, Crupi, R, Crepe Renaudin, S, Almenar, C, Donszelmann, T, Cuneo, S, Cunha, A, Curatolo, M, Curtis, C, Cwetanski, P, Czyczula, Z, D'Auria, S, D'Onofrio, M, D'Orazio, A, Mello, A, Da Silva, P, Da Via, C, Dabrowski, W, Dahlhoff, A, Dai, T, Dallapiccola, C, Dallison, S, Dalmau, J, Daly, C, Dam, M, Dameri, M, Danielsson, H, Dankers, R, Dannheim, D, Dao, V, Darbo, G, Darlea, G, Daum, C, Dauvergne, J, Davey, W, Davidek, T, Davidson, D, Davidson, N, Davidson, R, Davies, M, Davison, A, Dawson, I, Dawson, J, Daya, R, De, K, Null, A, De Castro, S, Salgado, P, De Cecco, S, Null, G, De Groot, N, Null, J, De La Cruz Burelo, E, De La Taille, C, De Lotto, B, De Mora, L, Branco, M, De Pedis, D, Null, S, De Salvo, A, De Sanctis, U, De Santo, A, De Regie, J, De Zorzi, G, Dean, S, Deberg, H, Dedes, G, Dedovich, D, Defay, P, Degenhardt, J, Dehchar, M, Deile, M, Del Papa, C, Del Peso, J, Del Prete, T, Dell'Acqua, A, Dell'Asta, L, Della Pietra, M, Null, V, Delmastro, M, Delpierre, P, Delruelle, N, Delsart, P, Deluca, C, Demers, S, Demichev, M, Demirkoz, B, Deng, J, Deng, W, Denisov, S, Dennis, C, Derkaoui, J, Derue, F, Dervan, R, Desch, K, Deviveiros, P, Dewhurst, A, Dewilde, B, Dhaliwal, S, Dhullipudi, R, DI CIACCIO, A, Di Ciaccio, L, Di Domenico, A, Di Girolamo, A, Di Girolamo, B, Di Luise, S, Di Mattia, A, Di Nardo, R, Di Simone, A, Di Sipio, R, Diaz, M, Gomez, M, Diblen, F, Diehl, E, Dietl, H, Dietrich, J, Dietzsch, T, Diglio, S, Yagci, K, Dingfelder, D, Dionisi, C, Dipanjan, R, Dita, P, Dita, S, Dittus, F, Djama, F, Djilkibaev, R, Djobava, T, Wemans, A, Doan, T, Dobbs, M, Dobinson, R, Dobos, D, Dobson, E, Dobson, M, Dodd, J, Dogan, O, Doglioni, C, Doherty, T, Doi, Y, Dolejsi, J, Dolenc, I, Dolezal, Z, Dolgoshein, B, Dohmae, T, Domingo, E, Donega, M, Donini, J, Dopke, J, Doria, A, Dos Anjos, A, Dosil, M, Dotti, A, Dova, M, Dowell, J, Doxiadis, A, Doyle, A, Dragic, J, Drakoulakos, D, Drasal, Z, Drees, J, Dressnandt, N, Drevermann, H, Driouichi, C, Dris, M, Drohan, J, Dubbert, J, Dubbs, T, Duchovni, E, Duckeck, G, Dudarev, A, Dudziak, F, Duhrssen, M, Dur, H, Duerdoth, I, Duflot, L, Dufour, M, Dunford, M, Yildiz, H, Dushkin, A, Duxfield, R, Dwuznik, M, Dydak, F, Dzahini, D, Duren, M, Ebenstein, W, Ebke, J, Eckert, S, Eckweiler, S, Edmonds, K, Edwards, C, Efthymiopoulos, I, Egorov, K, Ehrenfeld, W, Ehrich, T, Eifert, T, Eigen, G, Einsweiler, K, Eisenhandler, E, Ekelof, T, El Kacimi, M, Ellert, M, Elles, S, Ellinghaus, F, Ellis, K, Ellis, N, Elmsheuser, J, Elsing, M, Ely, R, Emeliyanov, D, Engelmann, R, Engl, A, Epp, B, Eppig, A, Erdmann, J, Ereditato, A, Eremin, V, Eriksson, D, Ermoline, I, Ernst, J, Ernst, M, Ernwein, J, Errede, D, Errede, S, Ertel, E, Escalier, M, Escobar, C, Curull, X, Esposito, B, Etienne, F, Etienvre, A, Etzion, E, Evans, H, Evdokimov, V, Fabbri, L, Fabre, C, Facius, K, Fakhrutdinov, R, Falciano, S, Falou, A, Fang, Y, Fanti, M, Farbin, A, Farilla, A, Farley, J, Farooque, T, Farrington, S, Farthouat, P, Fassnacht, P, Fassouliotis, D, Fatholahzadeh, B, Fayard, L, Fayette, F, Febbraro, R, Federic, R, Fedin, O, Fedorko, I, Fedorko, W, Feligioni, L, Felzmann, C, Feng, C, Feng, E, Fenyuk, A, Ferencei, J, Ferland, J, Fernandes, B, Fernando, W, Ferrag, S, Ferrando, J, Ferrara, V, Ferrari, A, Ferrari, P, Ferrari, R, Ferrer, A, Ferrer, M, Ferrere, D, Ferretti, C, Ferro, F, Fiascaris, M, Fichet, S, Fiedler, F, Filipcic, A, Filippas, A, Filthaut, F, Fincke Keeler, M, Fiolhais, M, Fiorini, L, Firan, A, Fischer, G, Fischer, P, Fisher, M, Fisher, S, Flacher, H, Flammer, J, Fleck, I, Fleckner, J, Fleischmann, P, Fleischmann, S, Fleuret, F, Flick, T, Castillo, L, Flowerdew, M, Fohlisch, F, Fokitis, M, Martin, T, Fopma, J, Forbush, D, Formica, A, Forti, A, Fortin, D, Foster, J, Fournier, D, Foussat, A, Fowler, A, Fowler, K, Fox, H, Francavilla, P, Franchino, S, Francis, D, Franklin, M, Franz, S, Fraternali, M, Fratina, S, Freestone, J, French, S, Froeschl, R, Froidevaux, D, Frost, J, Fukunaga, C, Torregrosa, E, Fuster, J, Gabaldon, C, Gabizon, O, Gadfort, T, Gadomski, S, Gagliardi, G, Gagnon, P, Galea, C, Gallas, E, Gallas, M, Gallo, V, Gallop, B, Gallus, P, Galyaev, E, Gan, K, Gao, Y, Gapienko, V, Gaponenko, A, Garcia Sciveres, M, Garcia, C, Navarro, J, Garde, V, Gardner, R, Garelli, N, Garitaonandia, H, Garonne, V, Garvey, J, Gatti, C, Gaudio, G, Gaumer, O, Gauzzi, P, Gavrilenko, I, Gay, C, Gaycken, G, Gayde, J, Gazis, E, Ge, R, Gee, C, Geich Gimbel, C, Gellerstedt, K, Gemme, C, Genest, M, Gentile, S, Georgatos, F, George, S, Gerlach, P, Gershon, A, Geweniger, C, Ghazlane, H, Ghez, P, Ghodbane, N, Giacobbe, B, Giagu, S, Giakoumopoulou, V, Giangiobbe, V, Gianotti, F, Gibbard, B, Gibson, A, Gibson, S, Gieraltowski, G, Gilbert, L, Gilchriese, M, Gildemeister, O, Gilewsky, V, Gillman, A, Gingrich, D, Ginzburg, J, Giokaris, N, Giordani, M, Giordano, R, Giorgi, F, Giovannini, R, Giraud, P, Girtler, P, Giugni, D, Giusti, P, Gjelsten, B, Gladilin, L, Glasman, C, Glazov, A, Glitza, K, Glonti, G, Gnanvo, K, Godfrey, J, Godlewski, J, Goebel, M, Gopfert, T, Goeringer, C, Gossling, C, Gottfert, T, Goggi, V, Goldfarb, S, Goldin, D, Goldschmidt, N, Golling, T, Gollub, N, Golovnia, S, Gomes, A, Fajardo, L, Goncalo, R, Gonella, L, Gong, C, Gonidec, A, Null, H, Silva, M, Gonzalez Pineiro, B, Gonzalez Sevilla, S, Goodson, J, Goossens, L, Gorbounov, P, Gordon, H, Gorelov, I, Gorfine, G, Gorini, B, Gorini, E, Gorisek, A, Gornicki, E, Gorokhov, S, Gorski, B, Goryachev, V, Gosdzik, B, Gosselink, M, Gostkin, M, Gouanere, M, Eschrich, I, Gouighri, M, Goujdami, D, Goulette, M, Goussiou, A, Goy, C, Grabowska Bold, I, Grabski, V, Grafstrom, P, Grah, C, Grahn, K, Grancagnolo, F, Grancagnolo, S, Grassi, V, Gratchev, V, Grau, N, Gray, H, Gray, J, Graziani, E, Green, B, Greenfield, D, Greenshaw, T, Greenwood, Z, Gregor, I, Grenier, P, Grewal, A, Griesmayer, E, Griffiths, J, Grigalashvili, N, Grillo, A, Grimaldi, F, Grimm, K, Grinstein, S, Gris, P, Grishkevich, Y, Groer, L, Grognuz, J, Groh, M, Groll, M, Gross, E, Grosse Knetter, J, Groth Jensen, J, Gruwe, M, Grybel, K, Guarino, V, Guescini, F, Guicheney, C, Guida, A, Guillemin, T, Guler, H, Gunther, J, Guo, B, Gupta, A, Gusakov, Y, Gushchin, V, Gutierrez, A, Gutierrez, P, Guttman, N, Gutzwiller, O, Guyot, C, Gwenlan, C, Gwilliam, C, Haas, A, Haas, S, Haber, C, Haboubi, G, Hackenburg, R, Hadavand, H, Hadley, D, Haeberli, C, Haefner, P, Hartel, R, Hahn, F, Haider, S, Hajduk, Z, Hakobyan, H, Hakobyan, R, Haller, J, Hallewell, G, Hamacher, K, Hamilton, A, Hamilton, S, Han, H, Han, L, Hanagaki, K, Hance, M, Handel, C, Hanke, P, Hansen, C, Hansen, J, Hansen, P, Hansl Kozanecka, T, Hansson, P, Hara, K, Hare, G, Harenberg, T, Harper, R, Harrington, R, Harris, O, Harrison, K, Hart, J, Hartert, J, Hartjes, F, Haruyama, T, Harvey, A, Hasegawa, S, Hasegawa, Y, Hashemi, K, Hassani, S, Hatch, M, Hauff, D, Haug, S, Hauschild, M, Hauser, R, Havranek, M, Hawes, B, Hawkes, C, Hawkings, R, Hawkins, D, Hayakawa, T, Hayward, H, Haywood, S, Hazen, E, He, M, He, Y, Head, S, Hedberg, V, Heelan, L, Heim, S, Heinemann, B, Heinemann, F, Heisterkamp, S, Helary, L, Heldmann, M, Heller, M, Hellman, S, Helsens, C, Hemperek, T, Henderson, R, Hendriks, P, Henke, M, Henrichs, A, Correia, A, Henrot Versille, S, Henry Couannier, F, Hensel, C, Henss, T, Jimenez, Y, Hershenhorn, A, Herten, G, Hertenberger, R, Hervas, L, Hess, M, Hessey, N, Hidvegi, A, Higon Rodriguez, E, Hill, D, Hill, J, Hill, N, Hiller, K, Hillert, S, Hillier, S, Hinchliffe, I, Hindson, D, Hines, E, Hirose, M, Hirsch, F, Hirschbuehl, D, Hobbs, J, Hod, N, Hodgkinson, M, Hodgson, P, Hoecker, A, Hoeferkamp, M, Hoffman, J, Hoffmann, D, Hohlfeld, M, Holder, M, Hollins, T, Hollyman, G, Holmes, A, Holmren, S, Holy, T, Holzbauer, J, Homer, R, Homma, Y, Horazdovsky, T, Hori, T, Horn, C, Horner, S, Horvat, S, Hostachy, J, Hott, T, Hou, S, Houlden, M, Hoummada, A, Howe, T, Howell, D, Hrivnac, J, Hruska, I, Hryn'Ova, T, Hsu, P, Hsu, S, Huang, G, Hubacek, Z, Hubaut, F, Huegging, F, Huffman, B, Hughes, E, Hughes, G, Hughes Jones, R, Hurst, P, Hurwitz, M, Husemann, U, Huseynov, N, Huston, J, Huth, J, Iacobucci, G, Iakovidis, G, Ibbotson, M, Ibragimov, I, Ichimiya, R, Iconomidou Fayard, L, Idarraga, J, Idzik, M, Iengo, R, Igonkina, O, Ikegami, Y, Ikeno, M, Ilchenko, Y, Iliadis, D, Imbault, D, Imhaeuser, M, Imori, M, Ince, T, Inigo Golfin, J, Ioannou, R, Iodice, M, Ionescu, G, Quiles, A, Ishii, K, Ishikawa, A, Ishino, M, Ishizawa, Y, Ishmukhametov, R, Isobe, T, Issakov, V, Issever, C, Istin, S, Itoh, Y, Ivashin, A, Iwanski, W, Iwasaki, H, Izen, J, Izzo, V, Jackson, B, Jackson, J, Jackson, P, Jaekel, M, Jahoda, M, Jain, V, Jakobs, K, Jakobsen, S, Jakubek, J, Jana, D, Jansen, E, Jantsch, A, Janus, M, Jared, R, Jarlskog, G, Jeanty, L, Jelen, K, Jen La Plante, I, Jenni, P, Jeremie, A, Jez, P, Jezequel, S, Ji, W, Jia, J, Jiang, Y, Belenguer, M, Jin, G, Jin, S, Jinnouchi, O, Joffe, D, Johansen, L, Johansen, M, Johansson, K, Johansson, P, Johnert, S, Johns, K, Jon, Null, K, Jones, A, Jones, G, Jones, M, Jones, R, Jones, T, Jonsson, O, Joo, K, Joos, D, Joram, C, Jorge, P, Jorgensen, S, Juranek, V, Jussel, P, Kabachenko, V, Kabana, S, Kaci, M, Kaczmarska, A, Kado, M, Kagan, H, Kagan, M, Kagawa, S, Kaiser, S, Kajomovitz, E, Kalinin, S, Kalinovskaya, L, Kalinowski, A, Kama, S, Kambara, H, Kanaya, N, Kaneda, M, Kantserov, V, Kanzaki, J, Kaplan, B, Kapliy, A, Kaplon, J, Karagounis, M, Unel, M, Karr, K, Kartvelishvili, V, Karyukhin, A, Kashif, L, Kasmi, A, Kass, R, Kastanas, A, Kastoryano, M, Kataoka, M, Kataoka, Y, Katsoufis, E, Katzy, J, Kaushik, V, Kawagoe, K, Kawamoto, T, Kawamura, G, Kayl, M, Kayumov, F, Kazanin, V, Kazarinov, M, Kazi, S, Keates, J, Keeler, R, Keener, P, Kehoe, R, Keil, M, Kekelidze, G, Kelly, M, Kennedy, J, Kenyon, M, Kepka, O, Kerschen, N, Kersevan, B, Kersten, S, Kessoku, K, Ketterer, C, Khakzad, M, Khalil Zada, F, Khandanyan, H, Khanov, A, Kharchenko, D, Khodinov, A, Kholodenko, A, Khomich, A, Khoriauli, G, Khovanskiy, N, Khovanskiy, V, Khramov, E, Khubua, J, Kilvington, G, Kim, H, Kim, M, Kim, P, Kim, S, 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Subjects
Settore FIS/01 - Fisica Sperimentale, High Energy Physics::Experiment, Nuclear Experiment, 900 gev, minimum bias, multiplicities, lhc, charged-particle, atlas, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Abstract

The first measurements from proton–proton collisions recorded with the ATLAS detector at the LHC are presented. Data were collected in December 2009 using a minimum-bias trigger during collisions at a centre-of-mass energy of 900 GeV. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity, and the relationship between mean transverse momentum and charged-particle multiplicity are measured for events with at least one charged particle in the kinematic range |η|500 MeVpT>500 MeV. The measurements are compared to Monte Carlo models of proton–proton collisions and to results from other experiments at the same centre-of-mass energy. The charged-particle multiplicity per event and unit of pseudorapidity at η=0η=0 is measured to be 1.333±0.003(stat.)±0.040(syst.)1.333±0.003(stat.)±0.040(syst.), which is 5–15% higher than the Monte Carlo models predict.

Published
2010

40. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction

Author

Bonaca, MP, Bhatt, DL, Cohen, M, Steg, PG, Storey, RF, Jensen, EC, Magnani, G, Bansilal, S, Fish, MP, Im, K, Bengtsson, O, Ophuis, TO, Budaj, A, Theroux, P, Ruda, M, Hamm, C, Goto, S, Spinar, J, Nicolau, JC, Kiss, RG, Murphy, SA, Wiviott, SD, Held, P, Braunwald, E, Sabatine, MS, Morin, S, Dantzer, E, Acquilano, D, McGuire, RL, Gannon, JB, Gershman, E, Ahlbom, AM, Boberg, B, Abola, MT, Ardissino, D, Aylward, P, Corbalan, R, Dalby, A, Diaz, R, Hu, DY, Isaza, D, Kamensky, G, Kiss, R, Kontny, F, Lopez-Sendon, J, Medina, F, Montalescot, G, Nicolau, J, Paolasso, E, Parkhomenko, A, Van De Werf, F, Anderson, JL, White, HD, Verheugt, FWA, Pedersen, TR, DeMets, DL, Lowe, C, Arevalo, C, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Alvarisqueta, A, De Gennaro, N, Berli, M, Roude, AE, Di Gennaro, JA, Albisu, JF, Caccavo, A, Torres, M, Cuadrado, J, Bordoni, P, Cuello, J, Aviles, A, Glenny, A, Recoaro, R, Fernandez, R, Strada, BN, Fuentealba, V, Gallo, C, Duran, RG, Garcia, C, Hominal, M, Castoldi, M, Jure, H, Pacora, FF, Lorenzatti, A, Martinez, JM, Macin, S, Cocco, N, MacKinnon, I, Bagnato, MB, Marino, J, Cusimano, S, Arias, V, Focaccia, M, Muntaner, J, Mansilla, V, Poy, C, Prado, A, Paterlini, G, Montana, O, Camino, A, Sala, J, Luciani, C, Vico, M, Morell, Y, Dumont, C, Vottero, E, Zangroniz, P, Lescano, A, Morara, P, Marquez, LL, Patron, FR, Labarta, GB, Sivila, CD, Quiroga, AR, Maffei, L, Sassone, S, Rolandi, F, Vesentini, N, Carnero, G, Del Verme, S, Hershson, A, Figal, JC, Viso, ME, Hii, C, Smith, K, Singh, B, Acampo, M, Rogers, J, ODonoghue, M, Amerena, J, Long, A, Dart, A, Kay, S, Worthley, M, Nimmo, J, Lehman, R, Morrison, H, Dick, R, Savage, C, van Gaal, W, Park, M, Blombery, P, McCarthy, C, Oqueli, E, Hill, D, Sader, M, Vrachas, D, Purnell, P, Vibert, J, Collins, N, Gordon, A, Arstall, M, Rose, J, Aroney, C, Cleave, P, Fitzpatrick, M, Mackenzie, M, Garrahy, P, 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Glaza, M, Podolec, P, Wilkolek, P, Piepiorka, M, Piepiorka-Broniecka, M, Pluta, W, Ploch, M, Rynkiewicz, A, Mosakowska, K, Szpajer, M, Lesinski, D, Szwed, H, Jasek, S, Sciborski, R, Piotrowicz, R, Musial, W, Lisowska, A, Rekosz, J, Kasznicka, M, Korzeniak, R, Staneta, P, Konczakowski, P, Waluszek-Konczakowska, I, Cymerman, K, Lubinski, A, Grycewicz, T, Hiczkiewicz, J, Plucinski, M, Korol, M, Szczech, J, Hawro, M, Skorski, M, Cichon, K, Jankowski, M, Cygler, J, Ottomanska-Cygler, M, Korecki, J, Gulaj, E, Zechowicz, T, Zechowicz, M, Goch, A, Topolinski, B, Ogorek, M, Szczepanska, A, Wojewoda, P, Jagoda, E, Krzyzanowski, W, Muzyk-Osikowicz, M, Jaszczurowski, W, Stasiewski, A, Wietrzynska, J, Miklaszewicz, B, Beme, A, Sudnik, W, Matys, U, Ponikowski, P, Powierza, S, Kim, YH, Choi, DJ, Seung, KB, Lim, DS, Lee, SH, Kim, HS, Bae, JH, Hong, TJ, Hong, MK, Tahk, SJ, Kim, YJ, Yoon, J, Jeong, MH, Chae, JK, Cho, MC, Hong, SK, Hur, SH, Jeong, JO, Her, SH, Lee, JM, Chang, KC, Yoon, CH, Chang, K, Park, J, Choi, S, Park, K, Bae, Y, Lee, H, Kim, BK, Yoon, MH, Park, JS, Jang, H, Kim, C, Cho, EJ, Bae, J, Lee, D, Lee, J, Choi, YY, Dimulescu, D, Vintila, M, Fruntelata, A, Pirvu, O, Stanciulescu, G, Giuca, A, Militaru, C, Radoi, M, Bobescu, E, Crisu, D, Creteanu, M, Minescu, B, Bolohan, F, Manitiu, I, Bengus, C, Iosipescu, L, Ciobotaru, V, Basarab, G, Benedek, I, Constantinescu, M, Cristea, M, Capalneanu, R, Tatu-Chitoiu, G, Huidu, S, Protopopescu, L, Greavu, M, Diaconu, M, Blajan, D, Istratoaie, O, Lican, G, Bisoc, A, Doka, B, Jemna, D, Parasteac, M, Serban, L, Mihai, M, Cioca, G, Ochean, V, Costache, L, Andor, M, Stoica, D, Benedek, T, Sava, N, Anciu, M, Mot, S, Cornaciu, S, Boldueva, S, Golitsyn, S, Karpov, Y, Kobalava, Z, Konstantinov, V, Kuimov, A, Ezhov, M, Panov, A, Novikova, T, Simanenkov, V, Smolenskaya, O, Tsyba, L, Vishnevsky, A, Yakhontova, P, Kislyak, O, Demchenko, E, Yakovlev, A, Ermoshkina, L, Arkhipov, M, Galyavich, A, Strongin, L, Kosmacheva, E, Goloshchekin, B, Sidorenko, B, Izmozherova, N, Shustov, S, Orlikova, O, Lukyanov, Y, Koziolova, N, Nedogoda, S, Statsenko, M, Kotelnikov, M, Osipenko, M, Oshchepkova, E, Bolieva, L, Ryamzina, I, Pavlysh, E, Samokhvalova, M, Mironova, N, Buza, V, Shavarov, A, Serebrenitskaya, M, Khomyakova, L, Safarova, M, Lohovinina, N, Staroverov, I, Bitakova, F, Zakharova, N, Khurs, E, Belenky, D, Kositsyn, D, Rovnykh, Y, Kasatova, T, Lubinskaya, E, Omelchenko, M, Slukhaenko, I, Kozulin, A, Baleeva, L, Pochinka, I, Kizhvatova, N, Laptev, I, Bugrimova, M, Popov, A, Kovalevskaya, E, Orlikov, E, Paltsman, Z, Lamden, D, Surovtseva, M, Tsoma, V, Derevjanchenko, M, Streltsov, S, Bikbulatova, E, Dmitriev, V, Byazrova, S, Khovaeva, Y, Komandenko, O, Dlesk, A, Urban, M, Vinanska, D, Dzupina, A, Hranai, M, Cisar, P, Toth, P, Paulov, S, Sivak, V, Bolvanska, N, Pella, D, Palka, J, Nedelova, I, Benacka, J, Gergel, V, Hatalova, K, Kohut, P, Kovar, F, Knazeje, M, Macek, V, Sinska, R, Bugan, V, Badenhorst, JCW, Erasmus, L, Burgess, LJ, de Necker, I, Corbett, CH, Fouche, L, Dawood, SY, Conradie, C, Delport, EF, Kruger, M, Ebrahim, I, Bobak, C, Nethononda, MR, Nunkoo, T, van Rensburg, FPJ, Middle, R, Horak, AR, Henley, L, Mabin, TA, King, A, Ranjith, N, Ramdas, S, Roodt, A, Coetsee, E, Theron, H, Karsten, M, Van Zyl, LJ, Roscher, M, Venter, TP, de Kock, L, Becker, AC, Swanepoel, J, Ismail, SM, Dalby, AJ, Allman, J, Roux, JP, Christie, H, Naidoo, DP, Vawda, GHM, Manga, P, Olckers, W, Mpe, MT, Farrell, BM, Areses, ELD, Lopez, SV, Fernandez, JMC, Roldan, JG, Pavia, PG, Segovia, AG, Puig, JG, Garcia, VC, Aguilera, RM, Munoa, MD, Cortada, JB, Cereto, PC, Perez, IP, Cid, LP, Basilio, EG, Guerra, PC, Ortiz, AF, Balcones, LDV, Vera, TR, Martinez, JMG, Galvan, ED, Caballero, AH, Blanco, VMR, Lopez, JMR, Franco, MRP, Soriano, FR, Porcar, LC, Fillat, ARC, Moreno, SG, Montejano, MG, Guerrero, JMD, Coronado, JLB, Eizagaechevarria, NM, Araucua, GN, Rubio, AM, Roca, MC, Marimon, XGM, Perales, MV, Gonzalez, AB, Sastre, MP, Juanatey, JRG, Acuna, JMG, Al-Khalili, F, Lof, P, Bandh, S, Myllyla, L, Christensen, K, Johansson, K, Dellborg, M, Hultsberg-Olsson, G, Alstrom, P, Damm, TL, Erlinge, D, Brolin, G, Ravn-Fischer, PA, Johansson, P, Andreen, S, Linderfalk, C, Ram, B, Lindholm, CJ, Assarsson, E, Mooe, T, Lindberg, A, Paren, P, Moodh, J, Svensson, P, Andersson, I, Wodlin, P, Raschperger, A, Skogvard, P, Koch, A, Lind, N, Osberg, L, Nilsson, C, Svensson, K, Bengtsson, M, Samad, B, Nilsson, M, Berglund, E, Lundgren, C, Lindmark, K, Sundholm, C, Aladellie, L, Welin-Berger, B, Guneri, S, Dogan, NB, Ersanli, M, Coskun, U, Cayli, M, Seker, T, Camsari, A, Ozcan, T, Ongen, Z, Karadag, B, Boyaci, B, Sezenoz, B, Pekdemir, H, Hidayet, S, Erol, M, Yalcin, A, Sezer, M, Emet, S, Bozkurt, E, Ozen, MB, Lutay, Y, Dyadyk, O, Kholopov, L, Rudyk, I, Shaposhnikova, Y, Chopey, I, Ternuschak, T, Reshotko, D, Popova, G, Batushkin, V, Gema, A, Vizir, V, Berezyn, O, Lutai, M, Tovstukha, V, Shumakov, V, Pogurelska, O, Sirenko, Y, Rekovets, O, Kraiz, I, Kamenska, E, Tseluyko, V, Yakovleva, L, Yena, L, Artemenko, V, Koval, O, Kaplan, P, Karpenko, O, Nevolina, I, Bazilevych, A, Harbar, M, Rudenko, L, Beregova, O, Mostovyi, Y, Rasputina, L, Vatutin, M, Shevelok, A, Kovalenko, V, Polenova, N, Amosova, K, Tkachenko, L, Volkov, V, Zaprovalna, O, Storey, R, Thomas, M, Pell, A, Moriarty, A, Kinnin, M, Ahsan, A, Burton, J, ORourke, B, Young, J, Lang, C, Forbes, J, Rowlands, D, Hamill, S, Sprigings, D, Cadd, A, de Belder, M, Atkinson, B, Ramsey, M, Fagan, JC, Pye, M, Wright, L, Keeling, P, Hughes, D, Fraser, D, Phillips, H, Muthusamy, R, Lawan, M, Levy, T, Kennard, S, Bodalia, B, Mottram, J, Calvert, J, Brodie, K, Gunstone, A, Douglas, C, Trouton, T, Hunter, B, Gerber, R, Pepper, H, Mathur, A, Andiapen, M, Baumbach, A, Bowles, R, Hildick-Smith, D, McGregor, A, Loh, I, Plocky, J, Adams, K, Clemmer, K, Aggarwal, K, Burkhardt, V, Costa, M, Lemmertz, K, Anderson, J, York, T, Angiolillo, D, Green, E, Sperling, M, Vasquez, E, Aycock, G, Tatum, D, Amin, J, Davidson, A, Hendrix, E, Shepard, L, Strain, J, Michel, K, Talano, J, Szalanski, N, Berk, M, Ibarra, M, Bhagwat, R, Winterrowd, D, Bilazarian, S, Marsters, M, Blonder, R, Graf, L, Brilakis, E, Roesle, M, Byrd, L, Sullivan, A, Longo, J, Pennella, A, Westerhausen, D, Weil, R, Carr, K, Piazza, J, Carr, KW, Castello, R, Hawks, M, Chandna, H, Holly, D, Chandrashekhar, YS, Molinaro, N, Carter, M, Antonino, M, Kosmicki, D, Kelley, M, Richwine, R, Pazier, P, Glasgow, B, Bresee, S, Alexander, J, Concha, M, Martinez, E, Connelly, T, Schenks, R, Cooper, M, Garman, V, Condit, J, White, A, Fialkow, J, Mckercher, M, Luna, M, Soto, G, Prodafikas, J, Rambaud, B, Donovan, J, Mudd, D, Doty, W, Parsons, T, D'Urso, M, Bies, J, Han, J, Treadwell, M, Erickson, B, Dahl, P, Fattal, P, Braem, J, Felten, W, Prior, J, French, W, Barillas, O, Berger, R, Genova, E, Gelernt, M, Cockrell, D, Miller, G, Dumka, K, Gill, S, Elliot, S, Goldberg, R, Barrett, M, Gordon, P, Stern, L, Ayres, T, Rhule, V, Gupta, D, Holton, T, Haddad, T, Jain, J, Hakas, J, McSorley, J, Hamroff, G, Hollenweger, L, Wainwright, W, Jones, S, Casagrande, M, Casagrande, MG, Effat, M, Mardis, R, Henderson, D, Millard, D, Hermany, P, Meissner-Dengler, S, Hinchman, D, Luck, K, Hodson, R, Severson, L, Horwitz, P, Miller, K, Isserman, S, Moore, C, Jan, M, Bilyk, O, Kersh, R, DaCosta, A, Kim, E, Gonzales, C, Kmetzo, J, Taylor, D, Knutson, T, Belanger, B, Hage-Korban, E, Harrington, A, Murdock, D, Heiman, M, Dandekar, U, Khan, M, Khan, G, Lui, H, Holman, L, MacDonald, L, Derbyshire, S, Watkins, K, Mayer, N, Mitchell, B, McCullum, K, Delio-Cox, B, Mckay, R, Cloutier, J, McKenzie, M, Rodkey, K, McLaurin, B, Lack, A, Minisi, A, Jeter, D, Mitchell, R, Keane-Richmond, P, Stine, R, Bullivant, M, Morford, R, White, J, Oberoi, M, Geraldo-Abache, A, O'Dea, D, Mehta, R, Tang, N, Ong, S, Edwards, M, Osborne, J, Alonzo, C, Lev, V, Monroe, J, Popeil, L, Sorrentino, N, Portelli, J, Landi, T, Potu, R, Smith, N, Prashad, R, McDonough, C, Qureshi, M, Howe, A, Raikhel, M, Arsate, M, Rogers, W, Saag, L, Sangrigoli, R, Schwarz, L, Abu-Fadel, M, Hagee, A, Kinnaman, S, McDaniel, V, Wilson, V, Purcell, T, Roberts, J, Riofrio, K, Shah, U, Narang, S, Gredler, F, Knap, P, Shanes, J, Hansen, C, Sharma, M, Gibson, T, Sheldon, W, Bohn, A, Siegel, C, Tibbits, L, Singh, V, Nelson, M, Singh, N, Logwood, D, Randhawa, P, Vargas, B, Stegemoller, R, Cole, B, Aggarwal, R, Johnson, M, Steinhoff, J, Dunaway, B, Patel, K, Boomer, L, Taheri, H, Morgan, K, Tahirkheli, N, Santos, A, Thadani, U, Alexander, D, Bennett, W, Kelley, E, Thomas, J, Macnicholas, D, Varma, S, Evans, S, Vlastaris, A, Bittel, B, Voyce, S, Mack, B, Weiss, R, Fournier, T, Whitney, R, Orosco, C, Willis, J, VonGerichten, S, Wiseman, A, Sharrow, A, Wohns, D, Schuitema, J, Amin, M, Ramus, A, Wilson, W, Moeller, C, Newell, M, Tindell, L, Rivera, W, Kwierant, J, Bretton, E, Corbin, B, Labroo, A, Lopez, C, Brown, C, Craig, M, Lucca, M, Keinanen, T, Eisenberg, S, Fielding, M, Doorey, A, Squire, A, Suresh, D, Frost, J, Teklinski, A, Stone, B, Waksman, R, Griffin, S, Wharton, W, Blakely, J, Fishbein, G, Weller, C, Camp, A, Fisher, S, Meholick, A, Hejna, E, Anderson, R, Long, S, Parikh, S, Norton, N, Vijay, N, Washam, M, Smith, S, and Stepanov, N

Abstract

BACKGROUND The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial infarction has not been established. We investigated the efficacy and safety of ticagrelor, a P2Y(12) receptor antagonist with established efficacy after an acute coronary syndrome, in this context. METHODS We randomly assigned, in a double-blind 1: 1: 1 fashion, 21,162 patients who had had a myocardial infarction 1 to 3 years earlier to ticagrelor at a dose of 90 mg twice daily, ticagrelor at a dose of 60 mg twice daily, or placebo. All the patients were to receive low-dose aspirin and were followed for a median of 33 months. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The primary safety end point was Thrombolysis in Myocardial Infarction (TIMI) major bleeding. RESULTS The two ticagrelor doses each reduced, as compared with placebo, the rate of the primary efficacy end point, with Kaplan-Meier rates at 3 years of 7.85% in the group that received 90 mg of ticagrelor twice daily, 7.77% in the group that received 60 mg of ticagrelor twice daily, and 9.04% in the placebo group (hazard ratio for 90 mg of ticagrelor vs. placebo, 0.85; 95% confidence interval [CI], 0.75 to 0.96; P = 0.008; hazard ratio for 60 mg of ticagrelor vs. placebo, 0.84; 95% CI, 0.74 to 0.95; P = 0.004). Rates of TIMI major bleeding were higher with ticagrelor (2.60% with 90 mg and 2.30% with 60 mg) than with placebo (1.06%) (P < 0.001 for each dose vs. placebo); the rates of intracranial hemorrhage or fatal bleeding in the three groups were 0.63%, 0.71%, and 0.60%, respectively. CONCLUSIONS In patients with a myocardial infarction more than 1 year previously, treatment with ticagrelor significantly reduced the risk of cardiovascular death, myocardial infarction, or stroke and increased the risk of major bleeding. (Funded by AstraZeneca; PEGASUS-TIMI 54 ClinicalTrials.gov number, NCT01225562.)

Published
2015

42. Fibrillar Crimp as a Function of Collagen Microfibrils in Connective Tissues

Author

QUARANTA, MARILISA, Raspanti, M, DE PASQUALE, VIVIANA, Orsini, E, LEONARDI, LUISA, OTTANI, VITTORIA, FRANCHI, MARCO, QUARANTA, MARILISA, Raspanti, M, DE PASQUALE, VIVIANA, Orsini, E, LEONARDI, LUISA, OTTANI, VITTORIA, and FRANCHI, MARCO

Subjects
Fibrillar crimp, collagen, connective tissues
Published
2007

44. This title is unavailable for guests, please login to see more information.

Author

Buontempo, F., Orsini, E., Lonetti, A., Cappellini, A., Chiarini, F., Evangelisti, C., Melchionda, F., Pession, A., Bertaina, A., Locatelli, Franco, Bertacchini, J., Neri, L. M., Mccubrey, J. A., Martelli, A. M., Locatelli F. (ORCID:0000-0002-7976-3654), Buontempo, F., Orsini, E., Lonetti, A., Cappellini, A., Chiarini, F., Evangelisti, C., Melchionda, F., Pession, A., Bertaina, A., Locatelli, Franco, Bertacchini, J., Neri, L. M., Mccubrey, J. A., Martelli, A. M., and Locatelli F. (ORCID:0000-0002-7976-3654)

Published
2016

45. Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway

Author

Lonetti, A., Cappellini, A., Bertaina, A., Locatelli, Franco, Pession, A., Buontempo, F., Evangelisti, C., Orsini, E., Zambonin, L., Neri, L. M., Martelli, A. M., Chiarini, F., Locatelli F. (ORCID:0000-0002-7976-3654), Lonetti, A., Cappellini, A., Bertaina, A., Locatelli, Franco, Pession, A., Buontempo, F., Evangelisti, C., Orsini, E., Zambonin, L., Neri, L. M., Martelli, A. M., Chiarini, F., and Locatelli F. (ORCID:0000-0002-7976-3654)

Published
2016

47. Targeting Signaling Pathways in T-cell acute lymphoblastic leukemia initiating cells

Author

Martelli, Am, Lonetti, A, Buontempo, F, Ricci, F, Tazzari, Pl, Evangelisti, C, Bressanin, D, Cappellini, A, Orsini, E, and Chiarini, F

Subjects
Notch1, TOR Serine-Threonine Kinases, Antineoplastic Agents, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, PI3K/Akt/mTOR, Relapse, T-ALL, Targeted therapy, Animals, Humans, Neoplastic Stem Cells, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Signal Transduction
Published
2014

48. Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: Targeting the unfolded protein response signaling

Author

Buontempo, F. a, Orsini, E. a, Martins, L. R. b, Antunes, I. b, Lonetti, A. a, Chiarini, Cd, F., Tabellini, Giovanna, Evangelisti, Cd, C., Evangelisti, C. a, Melchionda, F. f, Pession, A. f, Bertaina, A. g, Locatelli, F. g, Mccubrey, J. A. h, Cappellini, A. i, Barata, J. T. b, Martelli, Acd, A. M., F. Buontempo, E. Orsini, L.R. Martin, I. Antune, A. Lonetti, F. Chiarini, G. Tabellini, C. Evangelisti, F. Melchionda, A. Pession, A. Bertaina, F. Locatelli, J.A. McCubrey, A. Cappellini, J.T. Barata, and A.M. Martelli.

Subjects
Cancer Research, PTEN, T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL), Casein kinase 2, Antineoplastic Agents, casein kinase 2, Mice, SCID, UPR, Biology, SCID, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, Mice, Inbred NOD, Tensin, Animals, Humans, Naphthyridines, Akt, PTEN, T-ALL, casein kinase 2, UPR, Casein Kinase II, Protein kinase B, Endoplasmic Reticulum Chaperone BiP, PI3K/AKT/mTOR pathway, Akt, T-ALL, Cell Division, Neoplasm Proteins, Phenazines, Signal Transduction, Unfolded Protein Response, 030304 developmental biology, 0303 health sciences, fungi, Hematology, Oncology, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, 030220 oncology & carcinogenesis, Unfolded protein response, biology.protein, Cancer research, Inbred NOD, Signal transduction
Abstract

Constitutively active casein kinase 2 (CK2) signaling is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). CK2 phosphorylates PTEN (phosphatase and tensin homolog) tumor suppressor, resulting in PTEN stabilization and functional inactivation. Downregulation of PTEN activity has an impact on PI3K/Akt/mTOR signaling, which is of fundamental importance for T-ALL cell survival. These observations lend compelling weight to the application of CK2 inhibitors in the therapy of T-ALL. Here, we have analyzed the therapeutic potential of CX-4945-a novel, highly specific, orally available, ATP-competitive inhibitor of CK2 alpha. We show that CX-4945 treatment induced apoptosis in T-ALL cell lines and patient T lymphoblasts. CX-4945 downregulated PI3K/Akt/mTOR signaling in leukemic cells. Notably, CX-4945 affected the unfolded protein response (UPR), as demonstrated by a significant decrease in the levels of the main UPR regulator GRP78/BIP, and led to apoptosis via upregulation of the ER stress/UPR cell death mediators IRE1 alpha and CHOP. In vivo administration of CX-4945 to a subcutaneous xenotransplant model of human T-ALL significantly delayed tumor growth. Our findings indicate that modulation of the ER stress/UPR signaling through CK2 inhibition could be exploited for inducing apoptosis in T-ALL cells and that CX-4945 may be an efficient treatment for those T-ALLs displaying upregulation of CK2 alpha/PI3K/Akt/mTOR signaling.

Published
2014

49. Osteobiography of a 19th century elderly woman with pertrochanteric fracture and osteoporosis: a multidisciplinary approach

Author

Mariotti V, Milella M, Orsini E, Trirè A, Ruggeri A, Gino Fornaciari, Minozzi S, Caramella D, Albisinni U, Gnudi S, Durante S, Todero A, Boanini E, Rubini K, Bigi A, Mg, Belcastro, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Alma Mater Studiorum Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Anthropological Institute and Museum, Universität Zürich [Zürich] = University of Zurich (UZH), Alma Mater Studiorum Department of Human, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa - Università di Pisa, Division of paleopathology, History of Medicine and Bioethics, Special Orthopedic-Trauma Pathology Department, Rizzoli Orthopedic Institute, Alma Mater Studiorum University of Bologna (UNIBO), Geoffroy, Gisèle, Valentina Mariotti, Marco Milella, Ester Orsini, Alessandra Trirè, Alessandro Ruggeri, Gino Fornaciari, Simona Minozzi, Davide Caramella, Ugo Albisinni, Saverio Gnudi, Stefano Durante, Antonio Todero, Elisa Boanini, Katia Rubini, Adriana Bigi, Maria Giovanna Belcastro, University of Zurich, and Mariotti, Valentina

Subjects
10207 Department of Anthropology, Aged, 80 and over, 300 Social sciences, sociology & anthropology, Hip Fractures, bone morphology, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Osteoporosi, Acetabulum, History, 19th Century, [SHS.ANTHRO-BIO] Humanities and Social Sciences/Biological anthropology, Anthropology, Physical, Radiography, 1201 Arts and Humanities (miscellaneous), non-union fracture, cristallinity, 3314 Anthropology, Humans, Osteoporosis, Female, Interdisciplinary Communication, palaeopathology, pertrochanteric fracture, osteoporosis
Abstract

In this paper the osteobiography of an elderly woman recovered from a cemetery tomb where she was buried in 1850, affected by hip fracture and osteoporosis, is described. The overall anthropological characteristics of the individual have been investigated. Macroscopic, radiographic, tomographic, microscopic, and chemical and structural examinations have been performed to give a detailed account of the condition of the skeleton. A non-union pertrochanteric fracture not surgically treated and probably due to senile osteoporosis was diagnosed. The consequences of the fracture to the bones show that this individual likely survived several years following the injury. The osseous features we describe (remodelled bone at the fracture site, asymmetry of entheseal changes likely related to the particular walking pattern of the individual) may be useful in personal identification of skeletons of legal interest. Regarding the recognition of osteoporosis in unearthed skeletons, our study underlines that the cortical thickness, microscopic features, degree of crystallinity and Ca/P ratio represent more useful elements than the mean bone density, mineral/matrix ratio and mineral maturity, which are more sensitive to diagenetic changes that affect the mineral phase post-mortem.

Published
2013

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