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2. The association of postoperative morbidity and age on 5‐year survival after colorectal surgery in the elderly population: a nationwide cohort study

Author

Ose, Ilze, primary, Rosen, Andreas Weinberger, additional, Bräuner, Karoline, additional, Colov, Emilie Barbara Palmgren, additional, Christensen, Mathilde Glud, additional, Mashkoor, Maliha, additional, Vogelsang, Rasmus Peuliche, additional, Gögenur, Ismail, additional, and Bojesen, Rasmus Dahlin, additional

Published
2024
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4. A nationwide comparison of short-term outcomes after transanal, open, laparoscopic, and robot-assisted total mesorectal excision

Author

Ose, Ilze, Perdawood, Sharaf Karim, Ose, Ilze, and Perdawood, Sharaf Karim

Abstract

AIM: Laparoscopic rectal cancer surgery has several limitations. Transanal total mesorectal excision (TaTME) can potentially overcome these limitations. The aim of this study was to compare the rates of non-radical surgery and anastomotic leakage after TaTME, open TME (OpTME), laparoscopic TME (LaTME) and robotic TME (RoTME) procedures in a nationwide cohort.METHODS: We extracted the demographic, perioperative and pathological data of patients who underwent a curative OpTME, LaTME, RoTME or TaTME procedure between January 2014 and December 2018 from the national database of the Danish Colorectal Cancer Group (DCCG). We conducted multiple group-comparisons, uni- and multivariate analyses to determine the factors associated with positive resection margin (+RM) and anastomotic leakage.RESULTS: We included 2393 patients (OpTME = 205, LaTME = 1163, RoTME = 713 and TaTME = 312). The rate of +RM was 5.7% after TaTME. The lowest rate of +RM was achieved after RoTME (8.2%, 4.7%, 2.52%, and 5.7%, after OpTME, LaTME, RoTME and TaTME respectively, p < 0.001). In multivariate analysis, having a T4 tumour and intraoperative bowel perforation were associated with the risk of +RM (p < 0.001, p < 0.001, respectively). The factors associated with anastomotic leakage in multivariate analysis were male gender, high BMI and intraoperative bowel perforation (p < 0.001, p = 0.049, p = 0.002, respectively). TaTME was associated with the highest rate of sphincter-saving procedures (79.8%, p < 0.001), the lowest rate of bowel perforation (2.9%, p = 0.028) and the lowest rate of conversion to open surgery (1.3%, p < 0.001).CONCLUSIONS: In a nationwide audit of TME approaches, the rate of +RM was lowest after RoTME. No differences were found between the four approaches regarding the risk of anastomotic leakage. TaTME offered advantages related to sphincter-saving, perforation and conversion.

Published
2021

5. Valsts un pašvaldību sociālie pabalsti

Author

Ose, Ilze, Skribāne, Irina, and Latvijas Universitāte. Ekonomikas un vadības fakultāte

Subjects
Ekonomika
Abstract

Latvijā pēdējos gados notiek straujas pārmaiņas, palielinās inflācija, pieaug iekšzemes kopprodukts u.c. ekonomikas attīstības rādītāji. Tādējādi valstij ir jādomā par dzīves līmeņa uzlabošanu, tas arī tiek darīts un tiek palielinātas algas, iedzīvotāji spētu apmierināt savas primārās vajadzības. Tomēr inflācijas un algu palielinājums ir nesamērīgs un tādējādi Latvija vēl joprojām atrodas pēdējā vietā ES valstu vidū - nabadzības līmenī. Darba mērķis ir izpētīt sociālo politiku, tās virzienus, kā arī apskatīt Latvijas ekonomisko attīstību un izanalizēt vienu no sociālās politikas virzieniem – sociālo palīdzību. Analizēta ir Olaines pašvaldība, tās izsniegtie pabalsti, to apmēri, izsniegšanas kārtība. Atslēgvārdi: sociālā politika, ekonomiskā attīstība, budžets, pašvaldība, sociālie pabalsti., Rapid changes are taking place in Latvia during the last years, the inflation is rising, gross domestic product as well as other indicators of the economic development are increasing. Therefore the government has to consider the improving the level of life; this is being realised, and the wages are being increased so that the population could satisfy their primary needs. However, the rise of the inflation and the increase of the wages is not proportional and thus Latvia still remains the last among the EU member states as regards the level of poverty. The objective of the work is to explore social policy, its trends as well as to examine the economic development of Latvia and analyse one of the fields of social policy, namely, social assistance. The analysis concerns Olaine local government, the allowances it has granted, their amount and the procedure of granting. Key words: social policy, economic development, budget, local government, social allowances.

Published
2008

6. Resumption of oncological therapy in patients with advanced cancer undergoing explorative laparotomy for bowel obstruction.

Author

Ose I, Gögenur I, and Tolstrup MB

Subjects
Adult, Aged, Aged, 80 and over, Antineoplastic Agents administration & dosage, Databases, Factual, Diagnostic Techniques, Surgical, Drug Administration Schedule, Female, Gastrointestinal Tract surgery, Humans, Intestinal Obstruction etiology, Logistic Models, Male, Middle Aged, Neoplasms complications, Odds Ratio, Postoperative Period, Retrospective Studies, Digestive System Surgical Procedures statistics & numerical data, Intestinal Obstruction diagnosis, Laparotomy statistics & numerical data, Medical Oncology methods, Neoplasms drug therapy
Abstract

Introduction: Obstruction of the gastrointestinal tract is a frequent surgical emergency experienced by patients with advanced cancers. We aimed to evaluate factors associated with resumption of post-operative chemotherapy in patients with advanced cancer undergoing explorative laparotomy for bowel obstruction., Methods: This retrospective cohort study was conducted between 2009 and 2013 at Herlev Hospital, Denmark. All patients with advanced cancer were identified from a local electronic database containing all emergency laparotomies. Adult patients with mechanical bowel obstruction were included if they had any kind of cancer and had been under active oncological treatment within the last eight weeks prior to surgery. Demographic, clinical, pre-, and post-operative data were collected and reviewed manually. Multivariate logistic regression analysis was performed to identify predictors for resuming oncological treatment., Results: A total of 76 patients admitted with bowel obstruction and undergoing oncological treatment within eight weeks before surgery were included. Post-operatively, cancer treatment was resumed in 58% of patients. An American Society of Anesthesiologists (ASA) score less-than III (odds ratio = 12.6 (95% confidence interval (CI): 2.9-54.6); p = 0.001) and a performance status less-than 3 (odds ratio = 9.7 (95% CI: 1.4-67.2); p = 0.021) were associated with resuming post-operative cancer treatment., Conclusions: We found that ASA score and performance status are associated with resumption of cancer treatment post-operatively and should be taken into consideration when considering the treatment strategy for patients with advanced cancer and malignant bowel obstruction., Funding: The authors received no financial support for the research, authorship, and/or publication of this article., Trial Registration: not relevant., (Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.)

Published
2020

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