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8. Mechanism of action of atpenin B on Raji cells.

Author

Oshino K, Kumagai H, Tomoda H, and Omura S

Subjects
Acyltransferases drug effects, Adenosine Triphosphate metabolism, Cell Line, Cell Survival drug effects, Coenzyme A Ligases drug effects, Dose-Response Relationship, Drug, Humans, Lipids biosynthesis, Microsomes, Liver enzymology, Pyridones, Antifungal Agents pharmacology, Cell Division drug effects
Abstract

Atpenin B, a new antifungal antibiotic produced by Penicillium sp. FO-125, inhibited the growth of Raji cells (IC50, 30 microM). The incorporation of [14C]leucine and [3H]thymidine into Raji cells was inhibited by atpenin B with IC50 values of 0.10 and 0.12 microM, respectively. The incorporation of [14C]palmitate into the cells was not inhibited but its incorporation into lipid fractions was inhibited by atpenin B (IC50, 0.13-0.24 microM). Studies on the site of atpenin B action demonstrated that atpenin B decreases the cellular adenosine 5'-triphosphate (ATP) level in Raji cells with IC50 value of 0.020 microM, suggesting the inhibition of ATP-generating system by atpenin B.

Published
1990
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