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18 results on '"Osono, Yasunori"'

4. Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse

Author

Woollett, Laura A., Osono, Yasunori, Herz, Joachim, and Dietschy, John M.

Subjects
Apolipoproteins -- Physiological aspects, Cholesterol, LDL -- Physiological aspects, Liver -- Physiological aspects, Science and technology
Abstract

A study was conducted to determine the mechanism for the inhibition of low density lipoprotein (LDL) uptake by the liver in mice lacking apolipoprotein E (apoE). The rates of cholesterol absorption and synthesis were measured while the kinetics of hepatic LDL-C transport was monitored in vivo in mice lacking apoE and with normal apoE. The apparent Michaelis constant was higher in mice with zero apoE than in normal mice, suggesting that apoE can act as a potent inhibitor of receptor-dependent LDL uptake.

Published
1995

7. Serum Insulin-like Growth Factor-1 in Centenarians: Implications of IGF-1 as a Rapid Turnover Protein

Author

Arai, Yasumichi, Hirose, Nobuyoshi, Yamamura, Ken, Shimizu, Ken-ichirou, Takayama, Michiyo, Ebihara, Yoshinori, and Osono, Yasunori

Subjects
Centenarians -- Physiological aspects, Insulin-like growth factor 1 -- Research, Aging -- Physiological aspects, Health, Seniors
Abstract

Background. It is well documented that serum insulin-like growth factor 1 (IGF-1) levels as well as growth hormone secretion decline with advancing age. Low levels of IGF-1 are shown to be associated with low activity of growth hormone, low lean mass, and high body fat mass; however, in the elderly, the relationship has not been confirmed. Methods. We studied serum IGF-1 levels in 49 centenarians, who are at the ultimate stage of physiological senescence, and investigated the possible relationship between IGF-1 and body mass index, lipid parameters, nutritional indices, physical and cognitive function, and frequency of hip fracture. As nutritional indices, serum levels of albumin, prealbumin, transferrin, and retinol binding protein were measured. Cognitive function of the centenarians was assessed by clinical dementia rating. Results. In the centenarians, the mean levels of IGF-1 were relatively low, indicating that there is an age-associated decline in IGF-1 even in the extremely old age. We demonstrated a strong association of IGF-1 with prealbumin and retinol binding protein ([r.sup.2] = .192, .195, respectively); however, there was no association with albumin, transferrin, or body mass index. Interestingly, centenarians with lower IGF-1 levels had a higher prevalence of definitive dementia. Conclusions. These data suggest that serum IGF-1 levels in the centenarians appeared to reflect their short-term nutritional status as a rapid turnover protein. It is also suggested that low levels of serum IGF-1 may be involved in the progression of dementia in the oldest old.

Published
2001

8. PRIME Screen—Revised

Author

Kobayashi, Hiroyuki, primary, Nemoto, Takahiro, additional, Koshikawa, Hiroki, additional, Osono, Yasunori, additional, Yamazawa, Ryoko, additional, Murakami, Masaaki, additional, Kashima, Haruo, additional, and Mizuno, Masafumi, additional

Published
2008
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10. Lipid and Lipoprotein Profile of Japanses Centenarians. High Prevalence of Hypo .BETA. Lipoproteinemia.

Author

Arai, Yasumichi, primary, Hirose, Nobuyoshi, additional, Kawamura, Masahide, additional, Homma, Satoki, additional, Hasegawa, Hiroshi, additional, Ishida, Hiroyuki, additional, Osono, Yasunori, additional, Shimizu, Kenichiro, additional, Nakamura, Yoshiro, additional, Sakamoto, Takuya, additional, Tada, Norio, additional, and Homma, Akira, additional

Published
1997
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11. Tokyo Centenarian Study. 5. Nutritional Status of Japanese Centenarians.

Author

Hirose, Nobuyoshi, primary, Arai, Yasumichi, additional, Kawamura, Masahide, additional, Homma, Satoki, additional, Hasegawa, Hiroshi, additional, Ishida, Hiroyuki, additional, Shimizu, Kenichiro, additional, Osono, Yasunori, additional, Takeda, Sumie, additional, Noji, Hiroyasu, additional, Homma, Akira, additional, and Nakamura, Yoshiro, additional

Published
1997
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15. The Expression of LRP mRNA in Human Atherosclerotic Lesions

Author

HIROSE, Nobuyoshi, primary, KOMIYAMA, Kazuo, additional, SHIMIZU, Kennichiro, additional, HONMA, Satoki, additional, ISHIYAMA, Remiko, additional, ISHIDA, Yukihiro, additional, OSONO, Yasunori, additional, KIKUCHI, Masao, additional, NAKAMURA, Ryuuichiro, additional, and NAKAMURA, Yoshiro, additional

Published
1994
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