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1. HOW DO PATIENTS UNDERGOING TREATMENT FOR ADDICTION (IN PARTICULAR ALCOHOLISM AND/OR NICOTINE DEPENDENCE) UNDERSTAND AND RESPOND TO GENETIC EXPLANATIONS OF THEIR DISEASE?: P161

Author: Partridge, B., Dingel, M., Ostergren, J., Robinson, M., McCormick, J. B., and Koenig, B. A.
Published: 2010

2. Prevalence and prognostic implications of electrocardiographic left ventricular hypertrophy in heart failure: evidence from the CHARM programme

Author: Hawkins, N.M., Wang, D., McMurray, J.J.V., Pfeffer, M.A., Swedberg, K., Granger, C.B., Yusuf, S., Pocock, S.J., Ostergren, J., Michelson, E.L., and Dunn, F.G.
Subjects: Electrocardiogram -- Usage, Electrocardiography -- Usage, Heart enlargement -- Research, Heart enlargement -- Diagnosis, Heart failure -- Research, Heart failure -- Diagnosis, Heart failure -- Care and treatment, Health
Published: 2007

3. Anglo-Scandinavian Cardiac Outcomes Trial: a brief history, rationale and outline protocol

Author: Sever, PS, Dahlöf, B, Poulter, NR, Wedel, H, Beevers, G, Caulfield, M, Collins, R, Kjeldsen, SE, McInnes, GT, Mehlsen, J, Nieminen, M, O’Brien, E, and Ostergren, J
Published: 2001
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4. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

Author: Rydén, L, Grant, Pj, Anker, Sd, Berne, C, Cosentino, F, Danchin, N, Deaton, C, Escaned, J, Hammes, Hp, Huikuri, H, Marre, M, Marx, N, Mellbin, L, Ostergren, J, Patrono, C, Seferovic, P, Uva, Ms, Taskinen, Mr, Tendera, M, Tuomilehto, J, Valensi, P, Zamorano, Jl, Achenbach, S, Baumgartner, H, Bax, Jj, Bueno, H, Dean, V, Erol, C, Fagard, R, Ferrari, R, Hasdai, D, Hoes, Aw, Kirchhof, P, Knuuti, J, Kolh, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, Mf, Ponikowski, P, Sirnes, Pa, Tamargo, Jl, Torbicki, A, Wijns, W, Windecker, S, De Backer, G, Ezquerra, Ea, Avogaro, Angelo, Badimon, L, Baranova, E, Betteridge, J, Ceriello, A, Funck Brentano, C, Gulba, Dc, Kjekshus, Jk, Lev, E, Mueller, C, Neyses, L, Nilsson, Pm, Perk, J, Reiner, Z, Sattar, N, Schächinger, V, Scheen, A, Schirmer, H, Strömberg, A, Sudzhaeva, S, Viigimaa, M, Vlachopoulos, C, Xuereb, Rg, Authors/Task Force Members, ESC Committee for Practice Guidelines, and Document, Reviewers
Subjects: Male, Epidemiology, Smoking Prevention, Impaired glucose tolerance, Diabetes mellitus, Patient-Centered Care, Medicine, Child, Diagnostics, Smoking, Middle Aged, Cardiovascular disease, Prognosis, Patient management, Coronary Interventions, Cardiovascular Diseases, Pre diabetes, Child, Preschool, Female, Cardiology and Cardiovascular Medicine, Pharmacological treatment, Adult, medicine.medical_specialty, Adolescent, 610 Medicine & health, Guidelines, Prediabetic State, Young Adult, Internal medicine, Humans, Exercise, Aged, Glycated Hemoglobin, business.industry, Task force, Prevention, Settore MED/09 - MEDICINA INTERNA, Infant, medicine.disease, Diet, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Risk factors, business, Diabetic Angiopathies
Published: 2013
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5. Effect of Sibutramine on Cardiovascular Outcomes in Overweight and Obese Subjects

Author: James, Wp, Caterson, Id, Coutinho, W, Finer, N, VAN GAAL LF, Maggioni, Ap, TORP-PEDERSEN, C, Sharma, Am, Shepherd, Gm, Rode, Ra, Renz, Cl, Van Gaal LF, Torp-Pedersen, C, Pepine, C, Pocock, S, Drexler, H, Swedberg, K, Sleight, P, Armstrong, P, Kerr, D, Dagenais, G, Brophy, J, Avezum, A, Bogaty, P, Fabbri, G, Galli, M, Hildebrandt, P, Mann, J, Ostergren, J, Sherman, D, Zannad, F, Colquhoun, D, Hollanders, G, e Forti A, Costa, Cifkova, R, Toubro, S, Ziegler, O, Scherbaum, Wa, Jordan, J, Halmy, L, Ferrannini, E, Santini, F, Gonzalez, C, Narkiewicz, K, Hancu, N, Payer, J, Pascual, J, Wilding, J, Campbell, L, Carey, D, Gerstman, M, Karrasch, J, Lefkovits, J, Marks, J, Marks, S, Moses, R, Phillips, P, Proietto, J, Roberts, D, Roberts-Thomson, P, Shaw, J, Simpson, R, Singh, B, Singleton Jeffries, W, Stuckey, B, Boland, J, Brohet, C, Coucke, F, Dendale, P, Jouret, G, Kolanowski, J, Kutnowski, M, Martens, F, Muls, E, Peiffer, F, Penninckx, H, Scheen, A, Schoors, D, Vaerenberg, M, Van Cleemput, J, Van Crombrugge, P, Van Kuyk, M, Verhaegen, A, Wollaert, B, de Albuquerque DC, Appolinario, J, de Godoy Matos AF, Gross, Jl, Halpern, A, Kerr Saraiva JF, Milagres, R, Repetto, G, Suplicy, Hl, Zanella, Mt, Bednarova, J, Cepelak, V, Cerny, P, Hainer, V, Havranek, P, Homza, M, Jansa, P, Karlicek, M, Kolesar, J, Kotik, I, Kucera, D, Kuchar, J, Kunc, M, Kvapil, M, Linhart, A, Machova, V, Matuska, J, Oral, I, Pavlas, J, Pesatova, S, Povolny, J, Semrad, B, Smetana, K, Soucek, M, Svacina, S, Tesinsky, P, Urbanek, R, Wasserburger, B, Zachoval, R, Zahumensky, E, Zidkova, E, Astrup, A, Dominguez, H, Faber, J, Hilderbrant, P, Kober, L, Perrild, H, Richelsen, B, Sogaard, P, Svendsen, Ol, Urhammer, S, Archambeaud, F, Basdevant, A, Borys, Jm, Bringer, J, Brunetiere, C, Charpentier, G, Cocaul-André, M, Dabadie, H, Dubreuil, A, Estour, B, Gautier, Jf, Gibault, T, Halimi, S, Hespel, Jp, Issa Sayegh, M, Krempf, M, Laville, M, Lecerf, Jm, Louvet, Jp, Penfornis, A, Ritz, P, Schlienger, Jl, Schmitt, B, Valensi, P, Baar, M, Beermann, J, Bock, M, Boenner, G, Dammann, Hg, Diehm, C, Ditschuneit, H, Gadow, J, Gehlhar, S, Gessner, S, Guthersohn, A, Hamann, A, Hanefeld, M, Hasenfuss, G, Herzner, A, Heun, Kc, Heufelder, Ae, Hohensee, H, Jacob, S, Krings, P, Krätzig, B, Krosse, B, Lehmann, Rt, Mindt-Prüfert, S, Maisch, B, Pfeiffer, Af, Richard, F, Rose, B, Schmidt, E, Scholze, J, Schreckenberg, A, Stuebler, P, Walter, J, Wirth, A, Wunderlich, J, Abraham, G, Altorjay, A, Augusztin, G, Csaszar, A, Czuriga, I, Dinnyes, J, Gero, L, Gyimesi, A, Janosi, A, Kovacs, I, Liziczai, I, Majtenyi, A, Medvegy, M, Nadhazi, Z, Pados, G, Polak, G, Ronaszeki, A, Sido, Z, Simon, K, Anzà, C, Bevilacqua, M, Bosello, O, Chiariello, M, Cordera, R, Ferrari, E, Frittitta, L, Giorgino, R, Liuzzi, A, Malinverni, C, Di Mario, U, Melchionda, N, Occhi, G, Perticone, F, Pinchera, A, Pinelli, G, Rovera, G, Santeusanio, F, Urbinati, S, Alpizar-Salazar, M, Carrillo-Ortega, E, Fanghanel Salmon, G, Laviada-Molina, Ha, Madero, Ma, Rodriguez, G, Saldate, C, Sanchez-Castillo, Cp, Violante, Rm, Wacher, N, Zayas-Jaime, Fj, Zuniga-Guajardo, S, Adamiec, R, Banasiak, W, Chrusciel, P, Derlaga, B, Gebala, A, Gessek, J, Janik, K, Janion, M, Kalina, Z, Kozlowski, A, Kusnierz, B, Majcher, Z, Miekus, P, Niegowska, J, Okopien, B, Ostrowska, L, Pasowicz, M, Piepiorka, M, Pluta, W, Polaszewska-Muszynska, M, Ponikowski, P, Pupek-Musialik, D, Sawicki, A, Sobocik, H, Stankiewicz, A, Szpajer, M, Trojnar, R, Tykarski, A, Wrabec, K, Wyrzkowski, B, Zahorska-Markiewicz, B, Zalewski, M, Carrageta, M, Mendes Pedro MM, Parente Martins LM, dos Santos, L, Babes, A, Creteanu, G, Dan, Ga, Dragulescu, Si, Graur, M, Tirgoviste, Ci, Morosanu, M, Mota, M, Paveliu, Fs, Radoi, M, Ranetti, A, Totoian, I, Andre, I, Bugan, V, Cencarik, J, Csala, L, Farsky, S, Gonsorcik, J, Kamensky, G, Kmec, J, Krahulec, B, Kurian, R, Macek, V, Majercak, I, Micko, K, Mokan, M, Riecansky, I, Sojka, G, Uhliar, R, Urgeova, L, Vancik, J, Baro, Fm, Barrios Merino, A, Borras, Jl, Caixas, A, Cuatrecasas Cambra, G, Dominguez Escribano JR, Duran Garcia, S, Escobar-Jimenez, L, Esteva de Antonio, I, Formiguera Sala, X, Garcia-Luna, Pp, Garcia Robles, R, Gonzalez Albarran, O, Hernandez-Mijares, A, Martin Hidalgo, A, Masmiquel Comas, L, Morales Perez, F, Moreno Esteban, B, Pascual Izuel JM, Redon Mas, J, Ricart, W, Rubio, Ma, Ruilope, Lm, Salas-Salvado, J, Terroba Larumbe, M, Tinahones, F, de la Torre Casares ML, Vidal Cortada, J, Zuniga-Perez Lemaur, M, Abdulhakim, Ee, Adler, A, Barnett, Ah, Bodmer, C, Campbell, Iw, Chowdhury, T, Cleland, J, Cook, Rc, Dinneen, S, Donnachie, H, Haslam, Dw, Hillis, Gs, Horne, M, Howarth, Dj, Hughes, E, Jackson, S, Jones, Sc, Jones, Th, Kumar, S, Lean, M, Maroni, J, Mcinnes, G, Middleton, A, Morris, A, Newcombe, G, O'Kane, Kp, Pavel, Ic, Pawa, R, Perry, C, Pitts, C, Raja, A, Reckless, J, Robinson, J, Sarmiento, R, Soo, Sc, Taylor, S, Thomas, Ho, Thomson, Ma, and Wilkins, M.
Subjects: Male, medicine.medical_specialty, Myocardial Infarction, Blood Pressure, Kaplan-Meier Estimate, Type 2 diabetes, Klinikai orvostudományok, Placebo, law.invention, Double-Blind Method, Randomized controlled trial, Weight loss, law, Internal medicine, Appetite Depressants, medicine, Humans, Obesity, Myocardial infarction, Stroke, Aged, business.industry, Hazard ratio, Orvostudományok, General Medicine, Middle Aged, Overweight, medicine.disease, Surgery, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Cardiology, Female, Human medicine, medicine.symptom, business, Cyclobutanes, Sibutramine, medicine.drug
Abstract: Background The long-term effects of sibutramine treatment on the rates of cardiovascular events and cardiovascular death among subjects at high cardiovascular risk have not been established. Methods We enrolled in our study 10,744 overweight or obese subjects, 55 years of age or older, with preexisting cardiovascular disease, type 2 diabetes mellitus, or both to assess the cardiovascular consequences of weight management with and without sibutramine in subjects at high risk for cardiovascular events. All the subjects received sibutramine in addition to participating in a weight-management program during a 6-week, single-blind, lead-in period, after which 9804 subjects underwent random assignment in a double-blind fashion to sibutramine (4906 subjects) or placebo (4898 subjects). The primary end point was the time from randomization to the first occurrence of a primary outcome event (nonfatal myocardial infarction, nonfatal stroke, resuscitation after cardiac arrest, or cardiovascular death). Results The mean duration of treatment was 3.4 years. The mean weight loss during the lead-in period was 2.6 kg; after randomization, the subjects in the sibutramine group achieved and maintained further weight reduction (mean, 1.7 kg). The mean blood pressure decreased in both groups, with greater reductions in the placebo group than in the sibutramine group (mean difference, 1.2/1.4 mm Hg). The risk of a primary outcome event was 11.4% in the sibutramine group as compared with 10.0% in the placebo group (hazard ratio, 1.16; 95% confidence interval [CI], 1.03 to 1.31; P=0.02). The rates of nonfatal myocardial infarction and nonfatal stroke were 4.1% and 2.6% in the sibutramine group and 3.2% and 1.9% in the placebo group, respectively (hazard ratio for nonfatal myocardial infarction, 1.28; 95% CI, 1.04 to 1.57; P=0.02; hazard ratio for nonfatal stroke, 1.36; 95% CI, 1.04 to 1.77; P=0.03). The rates of cardiovascular death and death from any cause were not increased. Conclusions Subjects with preexisting cardiovascular conditions who were receiving long-term sibutramine treatment had an increased risk of nonfatal myocardial infarction and nonfatal stroke but not of cardiovascular death or death from any cause. (Funded by Abbott; ClinicalTrials.gov number, NCT00234832.)
Published: 2010
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6. The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis

Author: Berry, C, Doughty, R, Granger, C, Kober, L, Massie, B, Mcalister, F, Mcmurray, J, Pocock, S, Poppe, K, Swedberg, K, Somaratne, J, Whalley, G, Ahmed, A, Andersson, B, Bayes-Genis, A, Cowie, M, Cubbon, R, Ezekowitz, J, Gonzalez-Juanatey, J, Gorini, M, Gotsman, I, Grigorian-Shamagian, L, Guazzi, M, Kearney, M, Komajda, M, di Lenarda, A, Lenzen, M, Lucci, D, Macin, S, Madsen, B, Maggioni, A, Martinez-Selles, M, Oliva, F, Rich, M, Richards, M, Senni, M, Squire, I, Taffet, G, Tarantini, L, Tribouilloy, C, Troughton, R, Tsutsui, H, Earle, N, Perera, K, Dobson, J, Hall, C, Richards, A, Lainchbury, J, Hogg, K, Norrie, J, Stevenson, K, Brett, M, Pfeffer, M, Held, P, Michelson, E, Olofsson, B, Ostergren, J, Yusuf, S, Torp-Pedersen, C, Reimer, W, Boersma, E, Vantrimpont, P, Follath, F, Cleland, J, Zwas, D, Planer, D, Azaz-Livshits, T, Admon, D, Lotan, C, Keren, A, Varela-Roman, A, Mazon-Ramos, P, Rigeiro-Veloso, P, Bandin-Dieguez, M, Myers, J, Arena, R, Armstrong, P, Cujec, B, Paterson, I, Wood, D, Coats, A, Thompson, S, Suresh, V, Poole-Wilson, P, Sutton, G, Robles, J, Prieto, L, Munoa, M, Frades, E, Diaz-Castro, O, Almendral, J, Faggiano, P, Bertoli, D, Porcu, M, Opasich, C, Tavazzi, L, Kirk, V, Bay, M, Parner, J, Krogsgaard, K, Herzog, T, Boesgaard, S, Hassager, C, Nielsen, O, Aldershvile, J, Nielsen, H, Perna, E, Canella, J, Alvarenga, P, Pantich, R, Rios, N, Farias, E, Badaracco, J, Hansen, J, Stokholm, K, Brons, J, Husum, D, Mortensen, L, Vazquez, R, Puig, T, Fernandez-Palomeque, C, Bardaji, A, Pascual-Figal, D, Ordonez-Llanos, J, Valdes, M, Gabarrus, A, Pavon, R, Pastor, L, Fiol, M, Nieto, V, Macaya, C, Cinca, J, de Luna, A, Newton, J, Blackledge, H, Wright, S, Kerzner, R, Gage, B, Freedland, K, Huynh, B, Rovner, A, Carney, R, Teasdale, T, Bleyer, A, Kutka, N, Luchi, R, Rusinaru, D, Mahjoub, H, Souliere, V, Levy, F, Peltier, M, Tsuchihashi, M, Takeshita, A, Maccarthy, P, Nolan, J, Lee, A, Prescott, R, Shah, A, Brooksby, W, Fox, K, Basante, P, Trillo, R, Garcia-Seara, J, Martinez-Sande, J, Gude, F, Berry C, Doughty RN, Granger C, Kober L, Massie B, McAlister F, McMurray J, Pocock S, Poppe K, Swedberg K, Somaratne J, Whalley GA, Ahmed A, Andersson B, Bayes-Genis A, Cowie M, Cubbon R, Ezekowitz J, Gonzalez-Juanatey J, Gorini M, Gotsman I, Grigorian-Shamagian L, Guazzi M, Kearney M, Komajda M, di Lenarda A, Lenzen M, Lucci D, Macin S, Madsen B, Maggioni A, Martinez-Selles M, Oliva F, Rich M, Richards M, Senni M, Squire I, Taffet G, Tarantini L, Tribouilloy C, Troughton R, Tsutsui H, Earle N, Perera K, Dobson J, Whalley G, Hall C, Richards AM, Lainchbury J, Hogg K, Norrie J, Stevenson K, Brett M, Pfeffer MA, Granger CB, Held P, McMurray JJV, Michelson EL, Olofsson B, Ostergren J, Yusuf S, Torp-Pedersen C, Lenzen MJ, Reimer WJMS, Boersma E, Vantrimpont PJMJ, Follath F, Cleland J, Zwas D, Planer D, Azaz-Livshits T, Admon D, Lotan C, Keren A, Varela-Roman A, Mazon-Ramos P, Rigeiro-Veloso P, Bandin-Dieguez MA, Gonzalez-Juanatey JR, Myers J, Arena R, McAlister FA, Armstrong PW, Cujec B, Paterson I, Cowie MR, Wood DA, Coats AJS, Thompson SG, Suresh V, Poole-Wilson PA, Sutton GC, Robles JAG, Prieto L, Munoa MD, Frades E, Diaz-Castro O, Almendral J, Faggiano P, Bertoli D, Porcu M, Opasich C, Tavazzi L, Maggioni AP, Kirk V, Bay M, Parner J, Krogsgaard K, Herzog TM, Boesgaard S, Hassager C, Nielsen OW, Aldershvile J, Nielsen H, Macin SM, Perna ER, Canella JPC, Alvarenga P, Pantich R, Rios N, Farias EF, Badaracco JR, Madsen BK, Hansen JF, Stokholm KH, Brons J, Husum D, Mortensen LS, Vazquez R, Puig T, Fernandez-Palomeque C, Bardaji A, Pascual-Figal D, Ordonez-Llanos J, Valdes M, Gabarrus A, Pavon R, Pastor L, Fiol M, Nieto V, Macaya C, Cinca J, de Luna AB, Newton JD, Blackledge HM, Squire IB, Wright SP, Kerzner R, Gage BF, Freedland KE, Rich MW, Huynh BC, Rovner A, Carney RM, Taffet GE, Teasdale TA, Bleyer AJ, Kutka NJ, Luchi RJ, Rusinaru D, Mahjoub H, Souliere V, Levy F, Peltier M, Tsuchihashi M, Takeshita A, MacCarthy PA, Kearney MT, Nolan J, Lee AJ, Prescott RJ, Shah AM, Brooksby WP, Fox KAA, Basante P, Trillo R, Garcia-Seara J, Martinez-Sande JL, Gude F, Berry, C, Doughty, R, Granger, C, Kober, L, Massie, B, Mcalister, F, Mcmurray, J, Pocock, S, Poppe, K, Swedberg, K, Somaratne, J, Whalley, G, Ahmed, A, Andersson, B, Bayes-Genis, A, Cowie, M, Cubbon, R, Ezekowitz, J, Gonzalez-Juanatey, J, Gorini, M, Gotsman, I, Grigorian-Shamagian, L, Guazzi, M, Kearney, M, Komajda, M, di Lenarda, A, Lenzen, M, Lucci, D, Macin, S, Madsen, B, Maggioni, A, Martinez-Selles, M, Oliva, F, Rich, M, Richards, M, Senni, M, Squire, I, Taffet, G, Tarantini, L, Tribouilloy, C, Troughton, R, Tsutsui, H, Earle, N, Perera, K, Dobson, J, Hall, C, Richards, A, Lainchbury, J, Hogg, K, Norrie, J, Stevenson, K, Brett, M, Pfeffer, M, Held, P, Michelson, E, Olofsson, B, Ostergren, J, Yusuf, S, Torp-Pedersen, C, Reimer, W, Boersma, E, Vantrimpont, P, Follath, F, Cleland, J, Zwas, D, Planer, D, Azaz-Livshits, T, Admon, D, Lotan, C, Keren, A, Varela-Roman, A, Mazon-Ramos, P, Rigeiro-Veloso, P, Bandin-Dieguez, M, Myers, J, Arena, R, Armstrong, P, Cujec, B, Paterson, I, Wood, D, Coats, A, Thompson, S, Suresh, V, Poole-Wilson, P, Sutton, G, Robles, J, Prieto, L, Munoa, M, Frades, E, Diaz-Castro, O, Almendral, J, Faggiano, P, Bertoli, D, Porcu, M, Opasich, C, Tavazzi, L, Kirk, V, Bay, M, Parner, J, Krogsgaard, K, Herzog, T, Boesgaard, S, Hassager, C, Nielsen, O, Aldershvile, J, Nielsen, H, Perna, E, Canella, J, Alvarenga, P, Pantich, R, Rios, N, Farias, E, Badaracco, J, Hansen, J, Stokholm, K, Brons, J, Husum, D, Mortensen, L, Vazquez, R, Puig, T, Fernandez-Palomeque, C, Bardaji, A, Pascual-Figal, D, Ordonez-Llanos, J, Valdes, M, Gabarrus, A, Pavon, R, Pastor, L, Fiol, M, Nieto, V, Macaya, C, Cinca, J, de Luna, A, Newton, J, Blackledge, H, Wright, S, Kerzner, R, Gage, B, Freedland, K, Huynh, B, Rovner, A, Carney, R, Teasdale, T, Bleyer, A, Kutka, N, Luchi, R, Rusinaru, D, Mahjoub, H, Souliere, V, Levy, F, Peltier, M, Tsuchihashi, M, Takeshita, A, Maccarthy, P, Nolan, J, Lee, A, Prescott, R, Shah, A, Brooksby, W, Fox, K, Basante, P, Trillo, R, Garcia-Seara, J, Martinez-Sande, J, Gude, F, Berry C, Doughty RN, Granger C, Kober L, Massie B, McAlister F, McMurray J, Pocock S, Poppe K, Swedberg K, Somaratne J, Whalley GA, Ahmed A, Andersson B, Bayes-Genis A, Cowie M, Cubbon R, Ezekowitz J, Gonzalez-Juanatey J, Gorini M, Gotsman I, Grigorian-Shamagian L, Guazzi M, Kearney M, Komajda M, di Lenarda A, Lenzen M, Lucci D, Macin S, Madsen B, Maggioni A, Martinez-Selles M, Oliva F, Rich M, Richards M, Senni M, Squire I, Taffet G, Tarantini L, Tribouilloy C, Troughton R, Tsutsui H, Earle N, Perera K, Dobson J, Whalley G, Hall C, Richards AM, Lainchbury J, Hogg K, Norrie J, Stevenson K, Brett M, Pfeffer MA, Granger CB, Held P, McMurray JJV, Michelson EL, Olofsson B, Ostergren J, Yusuf S, Torp-Pedersen C, Lenzen MJ, Reimer WJMS, Boersma E, Vantrimpont PJMJ, Follath F, Cleland J, Zwas D, Planer D, Azaz-Livshits T, Admon D, Lotan C, Keren A, Varela-Roman A, Mazon-Ramos P, Rigeiro-Veloso P, Bandin-Dieguez MA, Gonzalez-Juanatey JR, Myers J, Arena R, McAlister FA, Armstrong PW, Cujec B, Paterson I, Cowie MR, Wood DA, Coats AJS, Thompson SG, Suresh V, Poole-Wilson PA, Sutton GC, Robles JAG, Prieto L, Munoa MD, Frades E, Diaz-Castro O, Almendral J, Faggiano P, Bertoli D, Porcu M, Opasich C, Tavazzi L, Maggioni AP, Kirk V, Bay M, Parner J, Krogsgaard K, Herzog TM, Boesgaard S, Hassager C, Nielsen OW, Aldershvile J, Nielsen H, Macin SM, Perna ER, Canella JPC, Alvarenga P, Pantich R, Rios N, Farias EF, Badaracco JR, Madsen BK, Hansen JF, Stokholm KH, Brons J, Husum D, Mortensen LS, Vazquez R, Puig T, Fernandez-Palomeque C, Bardaji A, Pascual-Figal D, Ordonez-Llanos J, Valdes M, Gabarrus A, Pavon R, Pastor L, Fiol M, Nieto V, Macaya C, Cinca J, de Luna AB, Newton JD, Blackledge HM, Squire IB, Wright SP, Kerzner R, Gage BF, Freedland KE, Rich MW, Huynh BC, Rovner A, Carney RM, Taffet GE, Teasdale TA, Bleyer AJ, Kutka NJ, Luchi RJ, Rusinaru D, Mahjoub H, Souliere V, Levy F, Peltier M, Tsuchihashi M, Takeshita A, MacCarthy PA, Kearney MT, Nolan J, Lee AJ, Prescott RJ, Shah AM, Brooksby WP, Fox KAA, Basante P, Trillo R, Garcia-Seara J, Martinez-Sande JL, and Gude F
Abstract: Aims: A substantial proportion of patients with heart failure have preserved left ventricular ejection fraction (HF-PEF). Previous studies have reportedmixed resultswhether survival is similar to those patientswith heart failure and reduced EF (HF-REF). Methods and results: We compared survival in patients with HF-PEF with that in patients with HF-REF in a meta-analysis using individual patient data. Preserved EF was defined as an EF ≥ 50%. The 31 studies included 41 972 patients: 10 347 with HF-PEF and 31 625 with HF-REF. Compared with patients with HF-REF, those with HF-PEF were older (mean age 71 vs. 66 years), were more often women (50 vs. 28%), and have a history of hypertension (51 vs. 41%). Ischaemic aetiology was less common (43 vs. 59%) in patients with HF-PEF. There were 121 [95% confidence interval (CI): 117, 126] deaths per 1000 patient-years in those with HF-PEF and 141 (95% CI: 138, 144) deaths per 1000 patient-years in those with HF-REF. Patients with HF-PEF had lower mortality than those with HF-REF (adjusted for age, gender, aetiology, and history of hypertension, diabetes, and atrial fibrillation); hazard ratio 0.68 (95% CI: 0.64, 0.71). The risk of death did not increase notably until EF fell below 40%. Conclusion: Patients with HF-PEF have a lower risk of death than patients with HF-REF, and this difference is seen regardless of age, gender, and aetiology of HF. However, absolute mortality is still high in patients with HF-PEF highlighting the need for a treatment to improve prognosis.
Published: 2012

7. Evolocumab and clinical outcomes in patients with cardiovascular disease

Author: Sabatine, M. S., Giugliano, R. P., Keech, A. C., Honarpour, N., Wiviott, S. D., Murphy, S. A., Kuder, J. F., Wang, H., Liu, T., Wasserman, S. M., Sever, P. S., Pedersen, T. R., Fish, M. P., Abrahamsen, T. E., Im, K., Kanevsky, E., Bonaca, M. P., Lira Pineda, A., Hanlon, K., Knusel, B., Somaratne, R., Kurtz, C., Scott, R., Accini Mendoza, J. L., Amerena, J., Badariene, J., Burgess, L., Ceska, R., Charng, M. J., Choi, D., Cobos, J. L., Dan, G. A., De Ferrari, G. M., Deedwania, P. C., Chopra, V. K., Erglis, A., Ezhov, M. V., Ferreira, J., Filipova, S., Gaciong, Z. A., Pasierski, T., Georgiev, B. G., Gonzalez-Galvez, G., Gouni-Berthold, I., Schaufele, T., Hirayama, A., Huber, K., Rammer, M., Kjaerulf Jensen, H., Wermuth, S., Jiang, L., Jukema, J. W., Kraydashenko, O., Leiter, L. A., Lewis, B. S., Lopez-Miranda, J., Lorenzatti, A. J., Mach, F., Mcadam, B., Nilsson, L., Olsson, A., Rallidis, L., Rogelio, G. G., Kerr Saraiva, J. F., Scheen, A., Schiele, F., Connolly, D., Siu, C. W., Tay, L., Thorgeirsson, G., Tikkanen, M. J., Tokgozoglu, S. L., Toth, K., Viigimaa, M., Wan Ahmad, W. A., Hennekens, C. H., Andreotti, F., Baigent, C., Brown, W. V., Davis, B. R., Newcomer, J. W., Wood, S. K., Larosa, J., Ansell, B., Lowe, C., Zahn, L., Awtry, E., Berger, C., Croce, K., Desai, A., Gelfand, E., Ho, C., Leeman, D., Link, M., Norden, A., Pande, A., Rost, N., Ruberg, F., Silverman, S., Singhal, A., Vita, J., Mackinnon, I., Vogel, D. R., Leon de la Fuente, R., Perna, E., Amuchastegui, M., Pacora, F., Hershson, A., Blumberg, E., Glenny, J. A., Colombo, H., Cuadrado, J. A., Nicolosi, L., Rojas, C. G., Ulla, M. R., Hasbani, E. G., Cuneo, C., Lopez Santi, R. G., Sanabria, H. D., Hrabar, A., Lozada, A., Begg, A., Lehman, S., Wittert, G., Juergens, C., Kostner, K., Beltrame, J., Simpson, R., Sinhal, A., Adams, M., Kritharides, L., Roberts Thomson, P., Cross, D., Thompson, P., Van Gaal, W., Cox, N., Farshid, A., Hammett, C., Garrahy, P., Prasan, A., Horrigan, M., Ebenbichler, C., Hanusch, U., Prager, R., Schernthaner, G., Luger, A., Siostrzonek, P., Toplak, H., Bergler-Klein, J., Paulweber, B., Sinzinger, H., Buysschaert, I., Thoeng, J., Vandekerckhove, H., Catez, E., Verheye, S., Descamps, O., Hoffer, E., Wollaert, B., Chenu, P., van de Borne, P., De Meulemeester, M., Friart, A., Charlier, F., De Raedt, H., Rietzschel, E., Roelandt, R., Lalmand, J., Tavares Russo, L. A., Reis, G., Duarte Barbosa, E. C., Vidotti, M. H., Fernandes Manenti, E. R., Dutra, O., Leaes, P. E., Rech, R. L., Bertolim Precoma, D., Nicolau, J. C., Amoedo, R., Eliaschewitz, F. G., Pereira, A., Kurtz Lisboa, H. R., Soares Piegas, L., Cunha Borges, J. L., Ferreira Rossi, P. R., Pimentel Filho, P., Bodanese, L. C., de Sa Cunha, R., Moura Jorge, J. C., Ardito, W. R., Barroso de Souza, W. K., Hissa, M., Izar, M. C., Manolova, A., Kitova, L., Kinova, E., Tzekova, M., Velchev, V., Tarnovska-Kadreva, R., Gotchev, D., Petrov, I., Raev, D., Trendafilova-Lazarova, D., Yotov, Y., Lazov, P., Rahimi, S., St Amour, E., Constance, C., Pesant, Y., Hess, A., Anderson, T., Sussex, B., Henein, S., Tsoukas, G., Pandey, A. S., Bergeron, J., Hart, R., Gosselin, G., Chehayeb, R., Hamet, P., Hartleib, M., Mukherjee, A., Halperin, F., Petrella, R., Bhargava, R., Lonn, E., Sabbah, E., Bata, I., Cha, J., Gaudet, D., Chapman, K., Murthy, D., Nigro, F., Rupka, D., Gossard, D., Gupta, M., Dowell, A., Mansour, S., Baass, A., Geadah, C., Huynh, T., Peterson, S., Poirier, P., Sabe-Affaki, G., Vertes, G., Crowley, D., Duchesne, L., Pincetti Jofre, C. P., Potthoff Cardenas, S., Conejeros Kindel, C., Saavedra Gajardo, V. A., Lanas Zanetti, F., Sepulveda Varela, P. A., Stockins Fernandez, B. A., Li, W., Li, D., Zhao, S., Li, Z., Wang, J., Yang, Y., Zhang, L., Yang, P., Zhang, X., Huang, H., Xue, L., Zheng, Z., Huang, W., Dai, H., Su, H., Zeng, X., Zheng, Y., Tang, Y., Yao, Z., Sun, Y., Du, Y., Ge, Z., Yan, J., Chen, X., Liu, F., Pei, H., Yang, X., Cui, H., Gu, Y., Yang, Z., Li, J., Lian, Y., Cui, Y., Wang, D., Jiang, J., Li, X., Chen, J., Mo, Z., Xu, P., He, Y., Zhou, C., Qu, P., Zhu, Y., Liu, Y., Shen, X., Gao, X., Terront Lozano, M. A., Moncada Corredor, M. A., Hernandez Triana, E., Botero Lopez, R., Coronel Arroyo, J. A., Quintero Baiz, A. E., Sanchez Vallejo, G., Arana Londono, C., Molina de Salazar, D. I., Castellanos Bueno, R., Manzur Jattin, F., Cure Cure, C. A., Sotomayor Herazo, A., Spinar, J., Hala, T., Machkova, M., Klimsa, Z., Polasek, R., Jerabek, O., Kazdera, P., Pozdisek, Z., Vaclavik, J., Frana, P., Elbl, L., Kucera, D., Kryza, R., Malecha, J., Reichert, P., Sochor, K., Ludka, O., Kellnerova, I., Peterka, K., Zidkova, E., Cech, V., Brabec, T., Fiserova, N., Kvasnicka, J., Rosolova, H., Nemecek, E., Adamkova, V., Dunaj, M., Pojsl, S., Cepelak, M., Podpera, I., Kuchar, L., Rysava, D., Burianova, H., Spinarova, L., Skrobakova, J., Charvat, J., Homza, M., Zemanek, J., Koleckar, P., Karen, I., Krupicka, J., Blaha, V., Matuska, J., Brotanek, J., Cifkova, R., Kuchar, R., Vomacka, Z., Kosek, Z., Hulinsky, V., Krejcova, H., Kuchar, J., Jelinek, Z., Jelinek, P., Markdanner Lindgren, L., Saetre Lihn, A., Korsgaard Thomsen, K., Bronnum-Schou, J., Nielsen, H., Nielsen, T., Egstrup, K., Klausen, I. C., Mickley, H., Hove, J., Jeppesen, J., Melchior, T., Schmidt, E. B., Valter, I., Rosenthal, A., Kaik, J., Kork, A., Alt, I., Strand, J., Nieminen, S., Kahri, J., Suomi, J., Nyman, K., Strandberg, T. E., Piippo, T., Savolainen, M., Vikman, S., Pucheu, Y., Cariou, B., Henry, P., Ferrari, E., Montalescot, G., Ferrieres, J., Roubille, F., Bonnet, B., Angoulvant, D., Range, G., Bammert, A., Delarche, N., Mariat, C., Cayla, G., Durlach, V., Coisne, D., Paillard, F., Rouzier, R., Goralski, M., Khanoyan, P., Cottin, Y., Ziegler, O., Khalife, K., Le Corvoisier, P., Motreff, P., Spaulding, C., Vanbelle, E., Bourhaial, H., Opitz, C., Kahrmann, G., Contzen, C., Appel, K., Schenkenberger, I., Rinke, A., Trenk, D., Maus, O., Karakas, M., Hanefeld, M., Darius, H., Hetzel, G., Munzel, T., Wohrle, J., Stawowy, P., Marten, I., Isermann, B., Kast, P., Vorpahl, M., Bosiljanoff, P., Hengstenberg, C., Kassner, U., Salbach, P., Fischer, M., Steiner, S., Wagner, S., Kraatz, U., von Hodenberg, E., Weyland, K., Mantas, I., Tziakas, D., Bousboulas, S., Patsilinakos, S., Mertzanos, G., Panagoulis, C., Bilianou, H., Skoumas, I., Elisaf, M., Manolis, A., Moschos, N., Kochiadakis, G., Ntaios, G., Richter, D., Athyros, V., Kolovou, G., Danias, P., Melidonis, A., Fan, K. Y. Y., Siu, S. C., Hornyik, A., Lakatos, F., Zilahi, Z., Nagy, K., Laszlo, Z., Peterfai, E., Lupkovics, G., Andreka, P., Merkely, B., Herczeg, B., Piros, G. A., Salamon, C., Mark, L., Papp, A., Szakal, I., Edes, I., Mohacsi, A., Tomcsanyi, J., Hajko, E., Nagy, A., Papp, E., Kiss, R., Karadi, I., Sigurdsson, A., Jain, A., Pai, R., Kothiwale, V., Kulkarni, G., Mahajan, A., Aggarwal, S., Mehta, V., Rajadhyaksha, G., Joshi, A., Khandait, V., Parmar, M., Tyagi, S., Airody Govinda, R., Dwivedi, S. K., Parikh, K., Pothineni, R. B., Solanki, B., O'Donnell, M., Crean, P., Barton, J., Shechter, M., Shotan, A., Klutstein, M., Chorin, E., Gavish, D., Kracoff, O., Atar, S., Rigler, S., Hasin, Y., Schiff, E., Merlini, P., Rapezzi, C., Pirro, M., Gonnelli, S., Floresta, A. M., Mennuni, M., Ardissino, D., Senni, M., Marenzi, G., Marcucci, R., Sampietro, T., Cosmi, F., Perrone Filardi, P., De Caterina, R., Fedele, F., Moretti, L., Biasucci, Luigi Marzio, Ferri, C., Go, Y., Kiyosue, A., Higashi, Y., Tokunaga, T., Kawasaki, T., Sakagami, S., Namba, S., Saku, K., Oku, K., Arakawa, T., Iida, H., Nakamura, Y., Yamamoto, K., Hata, Y., Katsuda, Y., Koga, Y., Shimizu, M., Uehara, H., Kajiyama, S., Okamoto, H., Shinozaki, T., Fujino, Y., Funazaki, T., Higa, N., Kaigawa, K., Koike, A., Nakane, H., Sato, K., Satoh, Y., Shirasawa, K., Sugino, H., Tanabe, J., Uemura, O., Yoshimichi, G., Akai, A., Himeno, H., Inage, T., Inoko, M., Kadokami, T., Noguchi, Y., Yamashita, K., Yasumura, Y., Yuge, M., Hosokawa, S., Kawamitsu, K., Kozuma, K., Matsuo, H., Nakashima, E., Okada, M., Wada, A., Yokoya, K., Iwade, K., Kawabata, K., Tanno, H., Ako, J., Fujita, H., Izumiya, Y., Kanno, M., Nunohiro, T., Ohmura, H., Ueno, T., Kakurina, N., Jasinkevica, I., Stukena, I., Veze, I., Eglite, R., Teterovska, D., Sime, I., Strazdiene, V., Venceviciene, L., Gustiene, O., Radzeviciene-Jurgute, R., Kucinskiene, A., Maskon, O., Lee, C. Y., Erng, T., Gan, H. W., Mohamed Yusof, A. K., Ramanathan, G. L., Liew, H., Lopez Alvarado, A., Nevarez Ruiz, L. A., De los Rios Ibarra, M. O., Bazzoni Ruiz, A. E., Ramos Lopez, G. A., Llamas Esperon, G. A., De la Pena Topete, G. D. J., Violante Ortiz, R. M., Illescas Diaz, J. J., Leon Gonzalez, S., Sanchez Diaz, C. J., Mendez Machado, G. F., Venegas Carrillo, L. A., Aldrete Velasco, J. A., Cardona Munoz, E. G., Leiva Pons, J. L., Perez Alva, J. C., van der Zwaan, C., Oomen, A., van de Wal, R., Magro, M., Boswijk, D., Janus, C., Groutars, R., Tonino, W., Cornel, J. H., Oude Ophuis, A., Troquay, R., Liem, A., Westendorp, I., Van Hessen, M., Lok, D., De Nooijer, C., Den Hartog, F., Van Beek, E., Bendermacher, P., Jansen, R., Romer, T., Rensing, B., Hersbach, F., Herrman, J., Ladyjanskaia, G., Karalis, I., Linssen, G., Bokern, M., Visman, A., Kooij, A., Monajemi, H., Lieverse, A., Baker, J., Tie, S., Risberg, K., Hysing, J., Hoivik, H. O., Norheim, P., Solnor, L., Hovland, A., Kjaernli, T., Jocson, G., Coching, R. M., Batalla, E., Go, A., Habaluyas, R., Barcinas, R., Sy, R. A., Estepar, R. A., Germar, A., Trebacz, J., Szymkowiak, K., Wnetrzak-Michalska, R., Kopaczewski, J., Przekwas-Jaruchowska, M., Kania, G., Zabowka, M., Mirek-Bryniarska, E., Dabrowska, M., Napora, P., Konieczny, M., Spyra, J., Lysek, R., Pijanowski, Z., Grzegorzewski, B., Bednarkiewicz, Z., Kinasz, L., Antkowiak-Piatyszek, K., Stania, K., Szpajer, M., Staneta, P., Skonieczny, G., Ksiezycka-Majczynska, E., Blicharski, T., Piepiorka, M., Wozakowska-Kaplon, B., Zechowicz, T., Ilkowski, J., Lubiszewska, B., Hiczkiewicz, J., Wierzbicka, K., Kosior, D., Garbocz, P., Kubica, J., Raczak, G., Wozniak, I., Cygler, J., Kramarczuk, E., Bystryk, L., Pentela-Nowicka, J., Dabrowski, M., Podolec, P., Zieba, B., Mosiewicz, J., Dubaniewicz, W., Banach, M., Tyszecka, G., Lepich, T., Rychlewska-Hanczewska, A., Guzik, T., Monteiro, P., Pereira, H., Oliveira, L., Matos, P., Soares Goncalves, S., Leitao, A., Vasco Salgado, A., Timoteo, A. T., Pintilei, E., Badila, E., Militaru, C., Tudoran, M., Arsenescu-Georgescu, C., Mitu, F., Zdrenghea, D., Lighezan, D., Teodorescu, I., Popescu, M. I., Coman, I., Vintila, M. M., Vishnevsky, A., Lukyanov, Y., Blokhin, A., Kostenko, V., Shvarts, Y., Markov, V., Motylev, I., Dronov, D., Sherenkov, A., Barbarash, O., Shutemova, E., Bolshakova, O., Kobalava, Z., Voevoda, M., Treshkur, T., Zrazhevskiy, K., Pimenov, L., Solovev, O., Tarasov, N., Arkhipov, M., Freidlin, M., Shalaev, S., Yakhontova, P., Shustov, S., Goloshchekin, B., Panov, A., Bart, B., Bubnova, M., Gordeev, I., Osipova, I., Tereshenko, S., Solovieva, E., Meshkov, A., Zateyshchikov, D., Tan, J. L., Subramaniam, T., Pella, D., Fulop, P., Antalik, L., Dzupina, A., Banikova, A., Sosovec, D., Urgeova, L., Mazur, J., Hranai, M., Banik, M., Vinanska, D., Lennerova, J., Kovar, F., Pastrnakova, E., Uhliar, R., Blasko, P., Gonsorcik, J., Lukacova, J., Oriesek, R., Hatalova, K., du Toit, M., Ebrahim, I., Vawda, G., Lipschitz, S., Blignaut, S., Engelbrecht, J., Coetzer, T. F., Pretorius, M., Urbach, D., Badat, A., Pillay, S., Van Zyl, L., Abelson, M., van der Walt, E., Moodley, R., Jacovides, A., Oosthuysen, W. M., Klug, E., Lottering, H., Kok, J., Saaiman, J., Dawood, S., De Jong, D. M., Kapp, C., Makotoko, E., Bayat, J., Sarvan, M., Vally, T., Stapelberg, A., Kim, M., Bae, J., Cho, Y., Kim, S., Han, K. H., Her, S., Kim, B., Lee, S., Hong, B., Kim, W., Rha, S., Jeong, M., Shin, G. J., Vida Gutierrez, M., Valdes Chavarri, M., Pinto Sala, X., Gonzalez Juanatey, J. R., Civeira Murillo, F., Zamorano Gomez, J. L., Lekuona Goya, I., Iniguez Romo, A., Cordero Fort, A., Ascaso Gimilio, J. F., Millan Nunez-Cortes, J., Lindholm, C., Soderberg, S., Suutari, A., Berglund, S., Mooe, T., Kusiak, D., Bandh, S., Dahlen, G., Olsson, S., Witt, N., Tyden, P., Johansson, P., Cizinsky, S., Falck, G., Pettersson, S. I., Rasmanis, G., Ostergren, J., Moccetti, T., Beer, H. J., Eberli, F., Krahenbuhl, S., Linka, A., Ackermann, D., Michel, P., Yeh, H., Tsai, C. F., Wu, C., Hsia, C., Juang, J., Hsieh, I., Lai, W., Huang, C., Hsieh, Y., Sahin, T., Duzenli, M., Yigit, Z., Demir, M., Yilmaz, M. B., Muderrisoglu, I. H., Kirma, C., Ercan, E., Kayikcioglu, L., Balbay, Y., Lymar, I., Kulynych, O., Prokhorov, O., Karpenko, O., Vakaliuk, I., Stanislavchuk, M., Korzh, O., Rudyk, I., Zhurba, S., Svishchenko, Y., Tseluyko, V., Gyrina, O., Reshotko, D., Kopytsya, M., Volkov, V., Myshanych, G., Rebrov, B., Rishko, M., Rudenko, L., Shatylo, V., Parkhomenko, O., Yena, L., Golovchenko, O., Sorokina, I., Malynovsky, Y., Ivan, P., Blagden, M., Dear, H., Mathew, A., Lagocki, S., Kondagunta, V., Ahsan, A., Mckinnon, C., Douglas, F., Thom, S., Fiore, G., Caulfield, M., Lynch, M., Thomas, H., Bain, S., Hall, A., Mcnally, D., Fisher, M., Keeling, P., Al-Bahrani, A., Lip, G., Ellery, A., Purohit, J., Travill, C., Cappuccio, F., Davis, G., Gaunt, R., Adlam, D., Asamoah, N., Jaafar, F., Mccormack, T., Jupp, B., Pye, M., Ainsworth, P., Chauhan, A., Paul, N., Fairlie, H., Fox, C., Muzulu, S., Trevelyan, J., Aggarwal, R., Issa, B., Saravanan, P., Cruickshank, K., Gorog, D., Heller, S., Newby, D., Nicolson, A., Hare, P. O., Donnelly, P., Rutherfurd, S., de Belder, M., Finlayson, J., Harvey, J., Hoye, A., Kingston, D., Sarkar, D., Negahban, A., Webster, J., Wyatt, N., Muir, S., Cummings, M., Mackenzie, I., Senior, R., Capps, N., Fotherby, K., Mcintyre, H., Aldegather, J., Dixon, L., Saksena, R., Butler, R., Ramstad, D., Pierpont, B., Levinson, D., Mohammed, A., Haddad, T., Goel, A., Dave, K., Haught, W. H., Desire, A., Hershon, K., Napoli, M., Tami, L., Rothschild, R., Khurana, S., Gupta, D., Cheung, D., Hearne, S., Grubb, S., Miller, A., Baird, I., Marcus, A., Srivastava, S., Forgosh, L., Fritz, R., Mays, M., Bertolet, B., Reddy, J., Khan, M., Nakhle, S., Dill, S., Fishbein, G., Khan, B., Marais, H., Reschak, M., Malone, M., Nadar, V., Whitney, R., Reichman, A., Reyes, H., El Shahawy, M., Rabinowitz, A., Weinstein, D., Farhat, N., Onyema, D., Potu, R., Runquist, L., Barnum, O., Crater, T., Fialkow, J., Shah, A., Thompson, C., Wiseman, A., Doyle, T., Henderson, D., Herzog, W., Schnitzler, R., Carr, K., Davis, M., Nagajothi, N., Olsen, S., Rogers, W., Rubino, J., Singh, I., Tarleton, G., Bhagwat, R., Clardy, D., Jardula, M., Robinson, J., Torres, M., Vijay, N., Farris, N., Lillo, J., Moriarty, P., Recknor, C., Berlacher, P., Christensen, T., Gabra, N., Issa, M., Janik, M., Lawless, A., Molter, D., Stout, E., Brezina, B., Claxton, E., Linsky, R., Poock, J., Remler, R., Roseman, H., Schramm, E., Al-Joundi, T., Amin, J., Hitchcock, J., Isserman, S., Kirstein, J., Rider, J., Shalek, M., Sherman, H., Bernstein, M., Chandra, L., Hatharasinghe, R., Ibrahim, H., Iteld, B., Linzmeyer, K., Seaton, B., Zeig, S., Christofides, E., Dunbar, R., Griffin, S., Kohli, N., Koren, M., Pharr, W., Purdy, D., Spencer, R., Yeoman, G., Banerjee, S., Cheek, H. B., Engel, E., Hamroff, G., Huling, R., Kozlowski, L., Levin, P., Makam, S., Meengs, M., Bhushan, R., Erickson, B., Herman, L., Lo, E., Mcdowell, E., Mcgrew, F., Miller, M., Ord, J., Webel, R., Wilhoit, G., Wise, J., Yang, E., Budoff, M., Collins, J., Dauber, I., Dobkin, L., Focil, A., Gandy, W., Pasquini, J., Ramos, M., Rodriguez, D., Rosenson, R., Sanford, K., Schlau, A., Snyder, B., Stonesifer, L., Tang, A., De Souza, J., Elam, M., French, J., Guyton, J., Hage Korban, E., Kereiakes, D., King, M., Loh, I., Navarro, J., Simons, R., Tobin, T., Younis, L., Aboufakher, R., Baldari, D., Ballantyne, C., Broughton, R., Eaton, C., Johnston, J., Simon, W., Thomson, S., Vora, K., Youngman, D., Alzohaili, O., Auerbach, E., Brown, C., Burrough, B., Chen, Y., Gilpatrick, M., Landzberg, J., Mitchell, C., Rice, L., Rubenfire, M., Sofley, C. W., Strobl, D., Atassi, K., Davila, W., Diogo, J., Fagan, T., Joffe, I., Krishna, J., Osea, E., Penny, W., Rowe, W., Shapiro, M., Welker, J., Benton, R., Dobratz, D., Fortuin, F., Graham, J., Henry, B., Kusnick, B., Lutskiy, M., Mcrae, A., Saway, W., Scott, J., Shah, M., Weinberg, B., Zarich, S., Acheatel, R., Case, C., Earl, J., Fernandez, S., Giugliano, G., Handelsman, Y., Hermany, P., Holder, S., Kashyap, M., Khan, A., Lader, E., Peniston, J., Raoof, T., Sacco, J., Shore, K., Spriggs, D., Stringam, S., Tahirkheli, N., Delgado, E., Derian, W., Greenwald, J., Harris, M., Jackson, R., Marhefka, G., Mcelveen, W., Mooss, A., Morris, P., Murray, J., Pearlstein, P., Raisinghani, A., Rezkalla, S., Sakhrani, L., Schreibman, D., Shaoulian, E., Steinsapir, J., Yataco, A., De La Cruz, A., Fredrick, M., Goldenberg, E., Lee, D., Mccullum, K., Mclellan, B., Stephens, L., Wilson, S., Alfieri, A., Mandviwala, M., Orourke, D., Samal, A., Schmedtje, J., Waxman, F., Carhart, R., Clements, B., Dyke, C., Ghali, J., Gruberg, L., Hack, T., Jehle, A., Pogue, B., Schooley, C., Shifrin, G., Biasucci L. M. (ORCID:0000-0002-6921-6497), Sabatine, M. S., Giugliano, R. P., Keech, A. C., Honarpour, N., Wiviott, S. D., Murphy, S. A., Kuder, J. F., Wang, H., Liu, T., Wasserman, S. M., Sever, P. S., Pedersen, T. R., Fish, M. P., Abrahamsen, T. E., Im, K., Kanevsky, E., Bonaca, M. P., Lira Pineda, A., Hanlon, K., Knusel, B., Somaratne, R., Kurtz, C., Scott, R., Accini Mendoza, J. L., Amerena, J., Badariene, J., Burgess, L., Ceska, R., Charng, M. J., Choi, D., Cobos, J. L., Dan, G. A., De Ferrari, G. M., Deedwania, P. C., Chopra, V. K., Erglis, A., Ezhov, M. V., Ferreira, J., Filipova, S., Gaciong, Z. A., Pasierski, T., Georgiev, B. G., Gonzalez-Galvez, G., Gouni-Berthold, I., Schaufele, T., Hirayama, A., Huber, K., Rammer, M., Kjaerulf Jensen, H., Wermuth, S., Jiang, L., Jukema, J. W., Kraydashenko, O., Leiter, L. A., Lewis, B. S., Lopez-Miranda, J., Lorenzatti, A. J., Mach, F., Mcadam, B., Nilsson, L., Olsson, A., Rallidis, L., Rogelio, G. G., Kerr Saraiva, J. 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W., Strobl, D., Atassi, K., Davila, W., Diogo, J., Fagan, T., Joffe, I., Krishna, J., Osea, E., Penny, W., Rowe, W., Shapiro, M., Welker, J., Benton, R., Dobratz, D., Fortuin, F., Graham, J., Henry, B., Kusnick, B., Lutskiy, M., Mcrae, A., Saway, W., Scott, J., Shah, M., Weinberg, B., Zarich, S., Acheatel, R., Case, C., Earl, J., Fernandez, S., Giugliano, G., Handelsman, Y., Hermany, P., Holder, S., Kashyap, M., Khan, A., Lader, E., Peniston, J., Raoof, T., Sacco, J., Shore, K., Spriggs, D., Stringam, S., Tahirkheli, N., Delgado, E., Derian, W., Greenwald, J., Harris, M., Jackson, R., Marhefka, G., Mcelveen, W., Mooss, A., Morris, P., Murray, J., Pearlstein, P., Raisinghani, A., Rezkalla, S., Sakhrani, L., Schreibman, D., Shaoulian, E., Steinsapir, J., Yataco, A., De La Cruz, A., Fredrick, M., Goldenberg, E., Lee, D., Mccullum, K., Mclellan, B., Stephens, L., Wilson, S., Alfieri, A., Mandviwala, M., Orourke, D., Samal, A., Schmedtje, J., Waxman, F., Carhart, R., Clements, B., Dyke, C., Ghali, J., Gruberg, L., Hack, T., Jehle, A., Pogue, B., Schooley, C., Shifrin, G., and Biasucci L. M. (ORCID:0000-0002-6921-6497)
Abstract: BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reacti
Published: 2017

8. The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis

Author: Berry C, Doughty RN, Granger C, Kober L, Massie B, McAlister F, McMurray J, Pocock S, Poppe K, Swedberg K, Somaratne J, Whalley GA, Ahmed A, Andersson B, Bayes-Genis A, Cowie M, Cubbon R, Ezekowitz J, Gonzalez-Juanatey J, Gorini M, Gotsman I, Grigorian-Shamagian L, Guazzi M, Kearney M, Komajda M, di Lenarda A, Lenzen M, Lucci D, Macin S, Madsen B, Maggioni A, Martinez-Selles M, Oliva F, Rich M, Richards M, Senni M, Squire I, Taffet G, Tarantini L, Tribouilloy C, Troughton R, Tsutsui H, Earle N, Perera K, Dobson J, Whalley G, Hall C, Richards AM, Lainchbury J, Hogg K, Norrie J, Stevenson K, Brett M, Pfeffer MA, Granger CB, Held P, McMurray JJV, Michelson EL, Olofsson B, Ostergren J, Yusuf S, Torp-Pedersen C, Lenzen MJ, Reimer WJMS, Boersma E, Vantrimpont PJMJ, Follath F, Cleland J, Zwas D, Planer D, Azaz-Livshits T, Admon D, Lotan C, Keren A, Varela-Roman A, Mazon-Ramos P, Rigeiro-Veloso P, Bandin-Dieguez MA, Gonzalez-Juanatey JR, Myers J, Arena R, McAlister FA, Armstrong PW, Cujec B, Paterson I, Cowie MR, Wood DA, Coats AJS, Thompson SG, Suresh V, Poole-Wilson PA, Sutton GC, Robles JAG, Prieto L, Munoa MD, Frades E, Diaz-Castro O, Almendral J, Faggiano P, Bertoli D, Porcu M, Opasich C, Tavazzi L, Maggioni AP, Kirk V, Bay M, Parner J, Krogsgaard K, Herzog TM, Boesgaard S, Hassager C, Nielsen OW, Aldershvile J, Nielsen H, Macin SM, Perna ER, Canella JPC, Alvarenga P, Pantich R, Rios N, Farias EF, Badaracco JR, Madsen BK, Hansen JF, Stokholm KH, Brons J, Husum D, Mortensen LS, Vazquez R, Puig T, Fernandez-Palomeque C, Bardaji A, Pascual-Figal D, Ordonez-Llanos J, Valdes M, Gabarrus A, Pavon R, Pastor L, Fiol M, Nieto V, Macaya C, Cinca J, de Luna AB, Newton JD, Blackledge HM, Squire IB, Wright SP, Kerzner R, Gage BF, Freedland KE, Rich MW, Huynh BC, Rovner A, Carney RM, Taffet GE, Teasdale TA, Bleyer AJ, Kutka NJ, Luchi RJ, Rusinaru D, Mahjoub H, Souliere V, Levy F, Peltier M, Tsuchihashi M, Takeshita A, MacCarthy PA, Kearney MT, Nolan J, Lee AJ, Prescott RJ, Shah AM, Brooksby WP, Fox KAA, Basante P, Trillo R, Garcia-Seara J, Martinez-Sande JL, Gude F, Berry, C, Doughty, R, Granger, C, Kober, L, Massie, B, Mcalister, F, Mcmurray, J, Pocock, S, Poppe, K, Swedberg, K, Somaratne, J, Whalley, G, Ahmed, A, Andersson, B, Bayes-Genis, A, Cowie, M, Cubbon, R, Ezekowitz, J, Gonzalez-Juanatey, J, Gorini, M, Gotsman, I, Grigorian-Shamagian, L, Guazzi, M, Kearney, M, Komajda, M, di Lenarda, A, Lenzen, M, Lucci, D, Macin, S, Madsen, B, Maggioni, A, Martinez-Selles, M, Oliva, F, Rich, M, Richards, M, Senni, M, Squire, I, Taffet, G, Tarantini, L, Tribouilloy, C, Troughton, R, Tsutsui, H, Earle, N, Perera, K, Dobson, J, Hall, C, Richards, A, Lainchbury, J, Hogg, K, Norrie, J, Stevenson, K, Brett, M, Pfeffer, M, Held, P, Michelson, E, Olofsson, B, Ostergren, J, Yusuf, S, Torp-Pedersen, C, Reimer, W, Boersma, E, Vantrimpont, P, Follath, F, Cleland, J, Zwas, D, Planer, D, Azaz-Livshits, T, Admon, D, Lotan, C, Keren, A, Varela-Roman, A, Mazon-Ramos, P, Rigeiro-Veloso, P, Bandin-Dieguez, M, Myers, J, Arena, R, Armstrong, P, Cujec, B, Paterson, I, Wood, D, Coats, A, Thompson, S, Suresh, V, Poole-Wilson, P, Sutton, G, Robles, J, Prieto, L, Munoa, M, Frades, E, Diaz-Castro, O, Almendral, J, Faggiano, P, Bertoli, D, Porcu, M, Opasich, C, Tavazzi, L, Kirk, V, Bay, M, Parner, J, Krogsgaard, K, Herzog, T, Boesgaard, S, Hassager, C, Nielsen, O, Aldershvile, J, Nielsen, H, Perna, E, Canella, J, Alvarenga, P, Pantich, R, Rios, N, Farias, E, Badaracco, J, Hansen, J, Stokholm, K, Brons, J, Husum, D, Mortensen, L, Vazquez, R, Puig, T, Fernandez-Palomeque, C, Bardaji, A, Pascual-Figal, D, Ordonez-Llanos, J, Valdes, M, Gabarrus, A, Pavon, R, Pastor, L, Fiol, M, Nieto, V, Macaya, C, Cinca, J, de Luna, A, Newton, J, Blackledge, H, Wright, S, Kerzner, R, Gage, B, Freedland, K, Huynh, B, Rovner, A, Carney, R, Teasdale, T, Bleyer, A, Kutka, N, Luchi, R, Rusinaru, D, Mahjoub, H, Souliere, V, Levy, F, Peltier, M, Tsuchihashi, M, Takeshita, A, Maccarthy, P, Nolan, J, Lee, A, Prescott, R, Shah, A, Brooksby, W, Fox, K, Basante, P, Trillo, R, Garcia-Seara, J, Martinez-Sande, J, and Gude, F
Subjects: Male, medicine.medical_specialty, Prognosi, Heart failure, Lower risk, Risk Factors, Cause of Death, Internal medicine, medicine, Humans, Meta-analysi, Aged, Randomized Controlled Trials as Topic, Ejection fraction, business.industry, Hazard ratio, Stroke Volume, Atrial fibrillation, medicine.disease, Confidence interval, Meta-analysis, Cardiology, Etiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Aims A substantial proportion of patients with heart failure have preserved left ventricular ejection fraction (HF-PEF). Previous studies have reported mixed results whether survival is similar to those patients with heart failure and reduced EF (HF-REF). Methods and results We compared survival in patients with HF-PEF with that in patients with HF-REF in a meta-analysis using individual patient data. Preserved EF was defined as an EF ≥ 50%. The 31 studies included 41 972 patients: 10 347 with HF-PEF and 31 625 with HF-REF. Compared with patients with HF-REF, those with HF-PEF were older (mean age 71 vs. 66 years), were more often women (50 vs. 28%), and have a history of hypertension (51 vs. 41%). Ischaemic aetiology was less common (43 vs. 59%) in patients with HF-PEF. There were 121 [95% confidence interval (CI): 117, 126] deaths per 1000 patient-years in those with HF-PEF and 141 (95% CI: 138, 144) deaths per 1000 patient-years in those with HF-REF. Patients with HF-PEF had lower mortality than those with HF-REF (adjusted for age, gender, aetiology, and history of hypertension, diabetes, and atrial fibrillation); hazard ratio 0.68 (95% CI: 0.64, 0.71). The risk of death did not increase notably until EF fell below 40%. Conclusion Patients with HF-PEF have a lower risk of death than patients with HF-REF, and this difference is seen regardless of age, gender, and aetiology of HF. However, absolute mortality is still high in patients with HF-PEF highlighting the need for a treatment to improve prognosis.
Published: 2012

9. ESC Guidelines on diabetes, pre- diabetes, and cardiovascular diseases developed in collaboration with the EASD - Summary

Author: Ryden, L, Grant, PJ, Anker, SD, Berne, C, Cosentino, F, Danchin, N, Escaned, J, Hammes, HP, Huikuri, H, Marre, M, Marx, N, Mellbin, L, Ostergren, J, Patrono, C, Seferovic, P, Sousa, M, Taskinen, MR, Tuomilehto, J, Valensi, P, Zamorano, JL, Achenbach, S, Bax, JJ, Bueno, H, Dean, V, Deaton, C, Erol, C, Ferrari, R, Kirchhof, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, MF, Tendera, M, Torbicki, A, Wijns, W, Windecker, S, De Backer, G, Sirnes, PA, Ezquerra, EA, Avogaro, A, Badimon, L, Baranova, E, Baumgartner, H, Betteridge, J, Ceriello, A, Fagard, R, Funck-Brentano, C, Gulba, DC, Hasdai, D, Hoes, AW, Kjekshus, JK, Knuuti, J, Kolh, P, Lev, E, Mueller, C, Neyses, L, Nilsson, PM, Perk, J, Ponikowski, P, Reiner, Z, Sattar, N, Schachinger, V, Scheen, A, Schirmer, H, Stromberg, A, Sudzhaeva, S, Tamargo, JL, Viigimaa, M, Vlachopoulos, C, and Xuereb, RG
Subjects: impaired glucose tolerance, prevention, pharmacological treatment, cardiovascular disease, diabetes mellitus, diagnostics, risk factors, coronary interventions, epidemiology, prognosis, Guidelines, patient management
Published: 2014

10. [ESC guidelines on diabetes, pre-diabetes and diseases of the cardiovascular system developed in cooperation with the EASD]

Author: Ryden, L., Grant, P. J., Anker, S. D., Berne, C., Cosentino, Francesco, Danchin, N., Deaton, C., Escaned, J., Hammes, H. P., Huikuri, H., Marre, M., Marx, N., Mellbin, L., Ostergren, J., Patrono, C., Seferovic, P., Sousa Uva, M., Taskinen, M. R., Tendera, M., Tuomilehto, J., Valensi, P., Zamorano, J. L., Towarzystwa Kardiologicznego Grupa Robocza Europejskiego, and Study Of Diabetes European Association For The
Subjects: Europe, Prediabetic State, Risk Management, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Diabetic Cardiomyopathies, Hypertension, Diabetes Mellitus, Disease Progression, Humans, Hypoglycemic Agents, Comorbidity, Dyslipidemias
Published: 2013

11. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD - Summary

Author: Ryden, L., Grant, P. J., Anker, S. D., Berne, C., Cosentino, Francesco, Danchin, N., Deaton, C., Escaned, J., Hammes, H. P., Huikuri, H., Marre, M., Marx, N., Mellbin, L., Ostergren, J., Patrono, C., Seferovic, P., Uva, M. S., Taskinen, M. R., Tendera, M., Tuomilehto, J., Valensi, P., Zamorano, J. L., Achenbach, S., Baumgartner, H., Bax, J. J., Bueno, H., Dean, V., Erol, C., Fagard, R., Ferrari, R., Hasdai, D., Hoes, A. W., Kirchhof, P., Knuuti, J., Kolh, P., Lancellotti, P., Linhart, A., Nihoyannopoulos, P., Piepoli, M. F., Ponikowski, P., Sirnes, P. A., Tamargo, J. L., Torbicki, A., Wijns, W., Windecker, S., De Backer, G., Ezquerra, E. A., Avogaro, A., Badimon, L., Baranova, E., Betteridge, J., Ceriello, A., Funck Brentano, C., Gulba, D. C., Kjekshus, J. K., Lev, E., Mueller, C., Neyses, L., Nilsson, P. M., Perk, J., Reiner, Z., Sattar, N., Schachinger, V., Scheen, A., Schirmer, H., Stromberg, A., Sudzhaeva, S., Viigimaa, M., Vlachopoulos, C., Xuereb, R. G., Authors/task Force Members, Committee For Practice Guidelines, E. S. C., and Reviewers, Document
Published: 2013

12. The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis

Author: Granger, C, Massie, B, Somaratne, J, Ahmed, A, Cowie, M, Gonzalez-Juanatey, J, Gorini, M, Kearney, M, di Lenarda, A, Lenzen, M, Macin, S, Madsen, B, Maggioni, A, McAlister, F, Oliva, F, Rich, M, Richards, M, Squire, I, Taffet, G, Earle, N, Perera, K, Dobson, J, Pocock, S, Poppe, K, Whalley, G, Andersson, B, Hall, C, Richards, AM, Troughton, R, Lainchbury, J, Berry, C, Hogg, K, Norrie, J, Stevenson, K, Brett, M, McMurray, J, Pfeffer, MA, Granger, CB, Held, P, McMurray, JJV, Michelson, EL, Olofsson, B, Ostergren, J, Yusuf, S, Torp-Pedersen, C, Lenzen, MJ, Reimer, WJMS, Boersma, E, Vantrimpont, PJMJ, Follath, F, Swedberg, K, Cleland, J, Komajda, M, Gotsman, I, Zwas, D, Planer, D, Azaz-Livshits, T, Admon, D, Lotan, C, Keren, A, Grigorian-Shamagian, L, Mazon-Ramos, P, Rigeiro-Veloso, P, Bandin-Dieguez, MA, Guazzi, M, Myers, J, Arena, R, McAlister, FA, Ezekowitz, J, Armstrong, PW, Cujec, B, Paterson, I, Cowie, MR, Wood, DA, Coats, AJS, Thompson, SG, Suresh, V, Poole-Wilson, PA, Sutton, GC, Martinez-Selles, M, Robles, JAG, Prieto, L, Munoa, MD, Frades, E, Diaz-Castro, O, Tarantini, L, Faggiano, P, Senni, M, Lucci, D, Bertoli, D, Porcu, M, Opasich, C, Tavazzi, L, Maggioni, AP, Kirk, V, Bay, M, Parner, J, Krogsgaard, K, Herzog, TM, Boesgaard, S, Hassager, C, Nielsen, OW, Aldershvile, J, Nielsen, H, Kober, L, Macin, SM, Perna, ER, Canella, JPC, Alvarenga, P, Pantich, R, Rios, N, Farias, EF, Badaracco, JR, Madsen, BK, Hansen, JF, Stokholm, KH, Brons, J, Husum, D, Mortensen, LS, Bayes-Genis, A, Vazquez, R, Puig, T, Fernandez-Palomeque, C, Bardaji, A, Pascual-Figal, D, Ordonez-Llanos, J, Valdes, M, Gabarrus, A, Pavon, R, Pastor, L, Almendral, J, Fiol, M, Nieto, V, Macaya, C, Cinca, J, de Luna, AB, Newton, JD, Blackledge, HM, Squire, IB, Wright, SP, Whalley, GA, Doughty, RN, Kerzner, R, Gage, BF, Huynh, BC, Rovner, A, Freedland, KE, Carney, RM, Rich, MW, Taffet, GE, Teasdale, TA, Bleyer, AJ, Kutka, NJ, Luchi, RJ, Tribouilloy, C, Rusinaru, D, Mahjoub, H, Souliere, V, Levy, F, Peltier, M, Tsutsui, H, Tsuchihashi, M, Takeshita, A, MacCarthy, PA, Kearney, MT, Cubbon, R, Nolan, J, Lee, AJ, Prescott, RJ, Shah, AM, Brooksby, WP, Fox, KAA, Varela-Roman, A, Gonzalez-Juanatey, JR, Basante, P, Trillo, R, Garcia-Seara, J, Martinez-Sande, JL, and Gude, F
Subjects: Meta-analysis, Heart failure, Prognosis
Abstract: A substantial proportion of patients with heart failure have preserved left ventricular ejection fraction (HF-PEF). Previous studies have reported mixed results whether survival is similar to those patients with heart failure and reduced EF (HF-REF). We compared survival in patients with HF-PEF with that in patients with HF-REF in a meta-analysis using individual patient data. Preserved EF was defined as an EF epsilon 50. The 31 studies included 41 972 patients: 10 347 with HF-PEF and 31 625 with HF-REF. Compared with patients with HF-REF, those with HF-PEF were older (mean age 71 vs. 66 years), were more often women (50 vs. 28), and have a history of hypertension (51 vs. 41). Ischaemic aetiology was less common (43 vs. 59) in patients with HF-PEF. There were 121 [95 confidence interval (CI): 117, 126] deaths per 1000 patient-years in those with HF-PEF and 141 (95 CI: 138, 144) deaths per 1000 patient-years in those with HF-REF. Patients with HF-PEF had lower mortality than those with HF-REF (adjusted for age, gender, aetiology, and history of hypertension, diabetes, and atrial fibrillation); hazard ratio 0.68 (95 CI: 0.64, 0.71). The risk of death did not increase notably until EF fell below 40. Patients with HF-PEF have a lower risk of death than patients with HF-REF, and this difference is seen regardless of age, gender, and aetiology of HF. However, absolute mortality is still high in patients with HF-PEF highlighting the need for a treatment to improve prognosis.
Published: 2012

13. Рекомендации Европейского общества кардиологов по диагностике и лечению заболеваний периферических артерий

Author: Tendera, Michal, Aboyans, Victor, Bartelink, M., Baumgartner, I., Clement, D., Collet, J., Cremonesi, A., De, Carlo, Erbel, R., FOWKES F.G.R., Heras, M., Kownator, S., Minar, E., Ostergren, J., Poldermans, D., Riambau, V., Roffi, M., Rother, J., Sievert, H., Van, Sambeek, and Zeller, T.
Subjects: ПОРАЖЕНИЕ ПЕРИФЕРИЧЕСКИХ АРТЕРИЙ,ПОРАЖЕНИЕ СОННЫХ АРТЕРИЙ,ПОРАЖЕНИЕ ПОЗВОНОЧНЫХ АРТЕРИЙ,ПОРАЖЕНИЕ АРТЕРИЙ ВЕРХНИХ КОНЕЧНОСТЕЙ,ПОРАЖЕНИЕ МЕЗЕНТЕРИАЛЬНЫХ АРТЕРИЙ,ПОРАЖЕНИЕ ПОЧЕЧНЫХ АРТЕРИЙ,ПОРАЖЕНИЕ АРТЕРИЙ НИЖНИХ КОНЕЧНОСТЕЙ,МНОГОСОСУДИСТОЕ ПОРАЖЕНИЕ АРТЕРИЙ
Abstract: Документ посвящен атеросклеротическому поражению экстракраниальных сонных и вертебральных, мезентериальных артерий, артерий почек, верхних и нижних конечностей
Published: 2012

14. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European Society of Cardiology (ESC)

Author: Tendera, M., Aboyans, V., Bartelink, M. l., Baumgartner, I., Clement, D., Collet, J. p., Cremonesi, A., De Carlo, M., Erbel, R., Fowkes, F. g. r., Heras, M., Kownator, S., Minar, E., Ostergren, J., Poldermans, D., Riambau, V., Roffi, M., Rother, J., Sievert, H., Van Sambeek, M., Zeller, T., Bax, J., Auricchio, A., Baumgartner, H., Ceconi, C., Dean, V., Deaton, C., Fagard, R., Funck Brentano, C., Hasdai, D., Hoes, A., Knuuti, J., Kolh, P., Mcdonagh, T., Moulin, C., Popescu, B., Reiner, Z., Sechtem, U., Sirnes, P. a., Torbicki, A., Vahanian, A., Windecker, S., Agewall, S., Blinc, A., Bulvas, M., Cosentino, Francesco, De Backer, T., Gottsater, A., Gulba, D., Guzik, T. j., Jonsson, B., Késmárky, G., Kitsiou, A., Kuczmik, W., Larsen, M. l., Madaric, J., Mas, J. l., Mcmurray, J. j., Micari, A., Mosseri, M., Muller, C., Naylor, R., Norrving, B., Oto, O., Pasierski, T., Plouin, P. f., Ribichini, F., Ricco, J. b., Ruilope, L., Schmid, J. p., Schwehr, U., Sol, B. g., Sprynger, M., Tiefenbacher, C., Tsioufis, C., Van Damme, H., Endorsed By: The European Stroke Organisation, Authors/task Force Members, Committee For Practice Guidelines, E. s. c., Reviewers, Document, Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Julius Centre for Health Sciences and Primary Health Care, Department of cardiology, Universität Duisburg-Essen [Essen], Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Institut Clinic de Tòrax, Department of Vascular Surgery, Erasmus Medical Centre, Department of Neurology, Asklepios Klinik Altona, Albert-Ludwigs-Universität Freiburg, Service de pharmacologie - Dosage de médicaments [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], CIC Saint-Antoine, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [APHP], Turku PET Centre, University of Turku, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), University Hospital Center Zagreb, Service de cardiologie, Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Karolinska Institute, karolinska institute, 1st Department of Internal Medicine, University of Pécs, Medical School, Cooltech Applications, Cooltech, Department of Neurology Lunds University Hospital Lund, Service de médecine vasculaire et hypertension artérielle [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Cardiology, Università degli Studi di Verona, Université de Limoges (UNILIM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Pécs Medical School (UP MS), University of Pecs-University of Pecs, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), and University of Verona (UNIVR)
Subjects: Male, medicine.medical_treatment, Carotid endarterectomy, 030204 cardiovascular system & hematology, Renal artery stenosis, MESH: Risk Assessment, Coronary artery disease, Coronary artery bypass surgery, 0302 clinical medicine, MESH: Aged, 80 and over, MESH: Risk Factors, Risk Factors, MESH: Peripheral Arterial Disease, 80 and over, 030212 general & internal medicine, Medical History Taking, ComputingMilieux_MISCELLANEOUS, Endarterectomy, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, Endovascular Procedures, Middle Aged, Prognosis, 3. Good health, Exercise Therapy, Cardiology, Female, Radiology, medicine.symptom, MESH: Cardiovascular Agents, Cardiology and Cardiovascular Medicine, Vascular Surgical Procedures, Adult, Diagnostic Imaging, medicine.medical_specialty, MESH: Endovascular Procedures, Risk Assessment, MESH: Prognosis, methods, 03 medical and health sciences, MESH: Physical Examination, Peripheral Arterial Disease, Angioplasty, Internal medicine, medicine, MESH: Exercise Therapy, Humans, cardiovascular diseases, MESH: Vascular Surgical Procedures, Physical Examination, Aged, MESH: Humans, business.industry, MESH: Diagnostic Imaging, MESH: Medical History Taking, MESH: Adult, Cardiovascular Agents, medicine.disease, Intermittent claudication, MESH: Male, MESH: Reperfusion, Adult, Aged, Aged, 80 and over, Cardiovascular Agents, therapeutic use, Diagnostic Imaging, Endovascular Procedures, methods, Exercise Therapy, Female, Humans, Male, Medical History Taking, Middle Aged, Peripheral Arterial Disease, diagnosis/therapy, Physical Examination, Prognosis, Reperfusion, methods, Risk Assessment, Risk Factors, Vascular Surgical Procedures, diagnosis/therapy, therapeutic use, Reperfusion, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Carotid stenting, business, MESH: Female
Abstract: 2D : two-dimensional 3D : three-dimensional ABI : ankle–brachial index ACAS : Asymptomatic Carotid Atherosclerosis Study ACCF : American College of Cardiology Foundation ACE : angiotensin-converting enzyme ACS : acute coronary syndrome ACST : Asymptomatic Carotid Surgery Trial ALI : acute limb ischaemia ASTRAL : Angioplasty and Stenting for Renal Artery Lesions trial BASIL : Bypass versus Angioplasty in Severe Ischaemia of the Leg BOA : Dutch Bypass Oral Anticoagulants or Aspirin CABG : coronary artery bypass grafting CAD : coronary artery disease CAPRIE : Clopidogrel versus Aspirin in Patients at Risk for Ischaemic Events CAPTURE : Carotid ACCULINK/ACCUNET Post Approval Trial to Uncover Rare Events CARP : Coronary Artery Revascularization Prophylaxis CAS : carotid artery stenting CASPAR : Clopidogrel and Acetylsalicylic Acid in Bypass Surgery for Peripheral Arterial Disease CASS : Coronary Artery Surgery Study CAVATAS : CArotid and Vertebral Artery Transluminal Angioplasty Study CEA : carotid endarterectomy CHARISMA : Clopidogrel for High Atherothrombotic Risk and Ischaemic Stabilization, Management and Avoidance CI : confidence interval CLEVER : Claudication: Exercise Versus Endoluminal Revascularization CLI : critical limb ischaemia CORAL : Cardiovascular Outcomes in Renal Atherosclerotic Lesions COURAGE : Clinical Outcomes Utilization Revascularization and Aggressive Drug Evaluation CPG : Committee for Practice Guidelines CREST : Carotid Revascularization Endarterectomy vs. Stenting Trial CT : computed tomography CTA : computed tomography angiography CVD : cardiovascular disease DECREASE-V : Dutch Echocardiographic Cardiac Risk Evaluation DRASTIC : Dutch Renal Artery Stenosis Intervention Cooperative Study DSA : digital subtraction angiography DUS : duplex ultrasound/duplex ultrasonography EACTS : European Association for Cardio-Thoracic Surgery EAS : European Atherosclerosis Society ECST : European Carotid Surgery Trial EPD : embolic protection device ESC : European Society of Cardiology ESH : European Society of Hypertension ESRD : end-stage renal disease EUROSCORE : European System for Cardiac Operative Risk Evaluation EVA-3S : Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis EXACT : Emboshield and Xact Post Approval Carotid Stent Trial GALA : General Anaesthesia versus Local Anaesthesia for Carotid Surgery GFR : glomerular filtration rate GRACE : Global Registry of Acute Coronary Events HbA1c : glycated haemoglobin HDL : high-density lipoprotein HOPE : Heart Outcomes Prevention Evaluation HR : hazard ratio IC : intermittent claudication ICSS : International Carotid Stenting Study IMT : intima–media thickness ITT : intention to treat LDL : low-density lipoprotein LEAD : lower extremity artery disease MACCEs : major adverse cardiac and cerebrovascular events MDCT : multidetector computed tomography MONICA : Monitoring of Trends and Determinants in Cardiovascular Disease MRA : magnetic resonance angiography MRI : magnetic resonance imaging NASCET : North American Symptomatic Carotid Endarterectomy Trial ONTARGET : Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial OR : odds ratio PAD : peripheral artery diseases PARTNERS : Peripheral Arterial Disease Awareness, Risk, and Treatment: New Resources for Survival PCI : percutaneous coronary intervention PET : positron emission tomography PRO-CAS : Predictors of Death and Stroke in CAS PTA : percutaneous transluminal angioplasty RAAS : renin–angiotensin–aldosterone system RADAR : Randomized, Multicentre, Prospective Study Comparing Best Medical Treatment Versus Best Medical Treatment Plus Renal Artery Stenting in Patients With Haemodynamically Relevant Atherosclerotic Renal Artery Stenosis RAS : renal artery stenosis RCT : randomized controlled trial REACH : Reduction of Atherothrombosis for Continued Health RR : risk ratio SAPPHIRE : Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy SCAI : Society for Cardiovascular Angiography and Interventions SIR : Society of Interventional Radiology SPACE : Stent-Protected Angioplasty versus Carotid Endarterectomy SPARCL : Stroke Prevention by Aggressive Reduction in Cholesterol Levels Study STAR : Stent Placement in Patients With Atherosclerotic Renal Artery Stenosis and Impaired Renal Function SSYLVIA : Stenting of Symptomatic Atherosclerotic Lesions in the Vertebral or Intracranial Arteries SVMB : Society for Vascular Medicine and Biology TASC : TransAtlantic Inter-Society Consensus TIA : transient ischaemic attack UEAD : upper extremity artery disease VA : vertebral artery Guidelines summarize and evaluate all available evidence, at the time of the writing process, on a particular issue with the aim of assisting physicians in selecting the best management strategies for an individual patient, with a given condition, taking into account the impact on outcome, as well as the risk–benefit ratio of particular diagnostic or therapeutic means. Guidelines are no substitutes but are complements for textbooks and cover the ESC Core Curriculum topics. Guidelines and recommendations should help the physicians to make decisions in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible physician(s). A large number of Guidelines have been issued in recent years by the European Society of Cardiology (ESC) as well as by other societies and organizations. Because of the impact on clinical practice, quality criteria for the development of guidelines have been established in order to make all decisions transparent to the user. The recommendations for formulating and issuing ESC Guidelines can be found on the ESC website (http://www.escardio.org/guidelines-surveys/esc-guidelines/about/Pages/rules-writing.aspx). ESC Guidelines represent the official position of the ESC on a given topic and are regularly updated. Members of this Task Force were selected by the ESC to represent professionals involved with the medical care of patients with this pathology. Selected experts in the field undertook a comprehensive review of the published evidence for diagnosis, management, and/or prevention of a given condition according to ESC Committee for Practice Guidelines (CPG) policy. A critical evaluation of diagnostic and therapeutic procedures was performed including assessment of the risk–benefit ratio. Estimates of expected health outcomes for larger populations were included, where data exist. The level of evidence and the strength of recommendation of particular treatment options were weighed and graded according to pre-defined scales, as outlined in Tables 1 and 2 . …
Published: 2011
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15. Where Are We With the Management of Hypertension? From Science to Clinical Practice

Author: Farsang, C, Naditch-Brule, L, Avogaro, A, Ostergren, J, Verdecchia, P, Maggioni, A, van de Borne, P, Lins, R, and Roca-Cusachs, A
Abstract: The management of elevated blood pressure in patients at high cardiovascular risk is still a subject of debate. The authors review current international guidelines and results of large clinical trials and recent meta-analyses to discuss the different approaches in patients at high risk for cardiovascular events. The different treatment options are considered in view of the modern approach and of the different classes of drugs (diuretics, angiotensin-converting enzyme inhibitors, calcium channel blockers, beta-blockers, and angiotensin II receptor blockers) currently in use. A case report is presented as an illustration of the difficulties related to the management of high blood pressure in patients at increased risk. The benefits of the use of 2 medications that include an inhibitor of the renin-angiotensin-aldosterone system and a calcium channel blocker or a diuretic are discussed. Choosing the proper drugs and correct doses are important considerations for the long-term management of hypertension.
Published: 2009

16. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text

Author: Ryden, L, Standl, E, Bartnik, M, Van den Berghe, G, Betteridge, J, de Boer MJ, Cosentino, F, Jonsson, B, Laakso, M, Malmberg, K, Priori, S, Ostergren, J, Tuomilehto, J, Thrainsdottir, I, Vanhorebeek, I, Stramba Badiale, M, Lindgren, P, Qiao, Q, Priori, Sg, Blanc, Jj, Budaj, A, Camm, J, Dean, V, Deckers, J, Dickstein, K, Lekakis, J, Mcgregor, K, Metra, M, Morais, J, Osterspey, A, Tamargo, J, Zamorano, Jl, Deckers, Jw, Bertrand, M, Charbonnel, B, Erdmann, E, Ferrannini, Eleuterio, Flyvbjerg, A, Gohike, H, Juanatey, Jrg, Graham, I, Monteiro, Pf, Parhofer, K, Pyorala, K, Raz, I, Schernthaner, G, Volpe, M, and Wood, D.
Published: 2007

17. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)

Author: Rydén, L, Standl, E, Bartnik, M, Van den Berghe, G, Betteridge, J, de Boer MJ, Cosentino, F, Jönsson, B, Laakso, M, Malmberg, K, Priori, S, Ostergren, J, Tuomilehto, J, Thrainsdottir, I, Vanhorebeek, I, Stramba Badiale, M, Lindgren, P, Qiao, Q, Priori, Sg, Blanc, Jj, Budaj, A, Camm, J, Dean, V, Deckers, J, Dickstein, K, Lekakis, J, Mcgregor, K, Metra, Marco, Morais, J, Osterspey, A, Tamargo, J, Zamorano, Jl, Deckers, Jw, Bertrand, M, Charbonnel, B, Erdmann, E, Ferrannini, E, Flyvbjerg, A, Gohlke, H, Juanatey, Jr, Graham, I, Monteiro, Pf, Parhofer, K, Pyörälä, K, Raz, I, Schernthaner, G, Volpe, M, Wood, D, Task Force on Diabetes, Cardiovascular Diseases of the European Society of Cardiology, and European Association for the Study of Diabetes
Published: 2007

18. Рекомендации по лечению сахарного диабета, преддиабета и сердечно-сосудистых заболеваний Рабочая группа по диабету и сердечно-сосудистым заболеваниям Европейского общества кардиологов и Европейской ассоциации по изучению диабета

Author: Ryden, L., Standl, E., Bartnik, M., VAN DEN BERGHE G., Betteridge, J., DE BOER M.J., Cosentino, F., Jonsson, B., Laakso, M., Malmberg, K., Priori, S., Ostergren, J., Tuomilehto, J., and Thrainsdottir, I.
Abstract: Авторы (члены рабочей группы): L. Ryden (сопредседатель), E. Standl (сопредседатель), M. Bartnik, G. Van den Berghe, J. Betteridge, M.J. de Boer, F. Cosentino, B. Jonsson, M. Laakso, K. Malmberg, S. Priori, J. Ostergren, J. Tuomilehto, I. Thrainsdottir Оригинальный текст опубликован в European Heart Journal (2007) 28, 88-136 © 2007 Европейское общество кардиологов. Адаптированный перевод с английского языка и тиражирование произведены с согласия Европейского общества кардиологов. Окончание (начало в РФК 2007; 4: 77-99)
Published: 2007

19. The Anglo-Scandinavian Cardiac Outcomes Trial: Blood pressure-lowering limb (ASCOT-BPLA): effects in patients with type 2 diabetes

Author: Ostergren, J, Sever, P, Poulter, N, Dahlof, B, Wedel, H, Beevers, G, Caulfield, M, Collins, R, Kjeldsen, S, Kristinsson, A, McInnes, G, Mehlsen, J, Nieminen, M, and OBrien, E
Published: 2006

20. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

Author: Ryden, L., primary, Grant, P. J., additional, Anker, S. D., additional, Berne, C., additional, Cosentino, F., additional, Danchin, N., additional, Deaton, C., additional, Escaned, J., additional, Hammes, H.-P., additional, Huikuri, H., additional, Marre, M., additional, Marx, N., additional, Mellbin, L., additional, Ostergren, J., additional, Patrono, C., additional, Seferovic, P., additional, Uva, M. S., additional, Taskinen, M.-R., additional, Tendera, M., additional, Tuomilehto, J., additional, Valensi, P., additional, and Zamorano, J. L., additional
Published: 2014
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21. 2013 ESH/ESC guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)

Author: Mancia, G, Fagard, R, Narkiewicz, K, Redon, J, Zanchetti, A, Böhm, M, Christiaens, T, Cifkova, R, De Backer, G, Dominiczak, A, Galderisi, M, Grobbee, D, Jaarsma, T, Kirchhof, P, Kjeldsen, S, Laurent, S, Manolis, A, Nilsson, P, Ruilope, L, Schmieder, R, Sirnes, P, Sleight, P, Viigimaa, M, Waeber, B, Zannad, F, Burnier, M, Ambrosioni, E, Caufield, M, Coca, A, Olsen, M, Tsioufis, C, Van De Borne, P, Zamorano, J, Achenbach, S, Baumgartner, H, Bax, J, Bueno, H, Dean, V, Deaton, C, Erol, C, Ferrari, R, Hasdai, D, Hoes, A, Knuuti, J, Kolh, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, M, Ponikowski, P, Tamargo, J, Tendera, M, Torbicki, A, Wijns, W, Windecker, S, Clement, D, Gillebert, T, Rosei, E, Anker, S, Bauersachs, J, Hitij, J, Caulfield, M, De Buyzere, M, De Geest, S, Derumeaux, G, Erdine, S, Farsang, C, Funck Brentano, C, Gerc, V, Germano, G, Gielen, S, Haller, H, Jordan, J, Kahan, T, Komajda, M, Lovic, D, Mahrholdt, H, Ostergren, J, Parati, G, Perk, J, Polonia, J, Popescu, B, Reiner, Ž, Rydén, L, Sirenko, Y, Stanton, A, Struijker Boudier, H, Vlachopoulos, C, Volpe, M, Wood, D, MANCIA, GIUSEPPE, PARATI, GIANFRANCO, Wood, D., Mancia, G, Fagard, R, Narkiewicz, K, Redon, J, Zanchetti, A, Böhm, M, Christiaens, T, Cifkova, R, De Backer, G, Dominiczak, A, Galderisi, M, Grobbee, D, Jaarsma, T, Kirchhof, P, Kjeldsen, S, Laurent, S, Manolis, A, Nilsson, P, Ruilope, L, Schmieder, R, Sirnes, P, Sleight, P, Viigimaa, M, Waeber, B, Zannad, F, Burnier, M, Ambrosioni, E, Caufield, M, Coca, A, Olsen, M, Tsioufis, C, Van De Borne, P, Zamorano, J, Achenbach, S, Baumgartner, H, Bax, J, Bueno, H, Dean, V, Deaton, C, Erol, C, Ferrari, R, Hasdai, D, Hoes, A, Knuuti, J, Kolh, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, M, Ponikowski, P, Tamargo, J, Tendera, M, Torbicki, A, Wijns, W, Windecker, S, Clement, D, Gillebert, T, Rosei, E, Anker, S, Bauersachs, J, Hitij, J, Caulfield, M, De Buyzere, M, De Geest, S, Derumeaux, G, Erdine, S, Farsang, C, Funck Brentano, C, Gerc, V, Germano, G, Gielen, S, Haller, H, Jordan, J, Kahan, T, Komajda, M, Lovic, D, Mahrholdt, H, Ostergren, J, Parati, G, Perk, J, Polonia, J, Popescu, B, Reiner, Ž, Rydén, L, Sirenko, Y, Stanton, A, Struijker Boudier, H, Vlachopoulos, C, Volpe, M, Wood, D, MANCIA, GIUSEPPE, PARATI, GIANFRANCO, and Wood, D.
Published: 2013

22. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD)

Author: Rydén, L, Grant, Pj, Anker, Sd, Berne, C, Cosentino, F, Danchin, N, Deaton, C, Escaned, J, Hammes, H, Huikuri, H, Marre, M, Marx, N, Mellbin, L, Ostergren, J, Patrono, Carlo, Seferovic, P, Uva, M, Taskinen, M, Tendera, M, Tuomilehto, J, Valensi, P, Zamorano, Jl, Achenbach, S, Baumgartner, H, Bax, Jj, Bueno, H, Dean, V, Erol, C, Fagard, R, Ferrari, R, Hasdai, D, Hoes, Aw, Kirchhof, P, Knuuti, J, Kolh, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, Mf, Ponikowski, P, Sirnes, Pa, Tamargo, Jl, Torbicki, A, Wijns, W, Windecker, S, De Backer, G, Ezquerra, Ea, Avogaro, A, Badimon, L, Baranova, E, Betteridge, J, Ceriello, A, Funck Brentano, C, Gulba, Dc, Kjekshus, Jk, Lev, E, Mueller, C, Neyses, L, Nilsson, Pm, Perk, J, Reiner, Z, Sattar, N, Schächinger, V, Scheen, A, Schirmer, H, Strömberg, A, Sudzhaeva, S, Viigimaa, M, Vlachopoulos, C, Xuereb, Rg, Rydén, L, Grant, Pj, Anker, Sd, Berne, C, Cosentino, F, Danchin, N, Deaton, C, Escaned, J, Hammes, H, Huikuri, H, Marre, M, Marx, N, Mellbin, L, Ostergren, J, Patrono, Carlo, Seferovic, P, Uva, M, Taskinen, M, Tendera, M, Tuomilehto, J, Valensi, P, Zamorano, Jl, Achenbach, S, Baumgartner, H, Bax, Jj, Bueno, H, Dean, V, Erol, C, Fagard, R, Ferrari, R, Hasdai, D, Hoes, Aw, Kirchhof, P, Knuuti, J, Kolh, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, Mf, Ponikowski, P, Sirnes, Pa, Tamargo, Jl, Torbicki, A, Wijns, W, Windecker, S, De Backer, G, Ezquerra, Ea, Avogaro, A, Badimon, L, Baranova, E, Betteridge, J, Ceriello, A, Funck Brentano, C, Gulba, Dc, Kjekshus, Jk, Lev, E, Mueller, C, Neyses, L, Nilsson, Pm, Perk, J, Reiner, Z, Sattar, N, Schächinger, V, Scheen, A, Schirmer, H, Strömberg, A, Sudzhaeva, S, Viigimaa, M, Vlachopoulos, C, and Xuereb, Rg
Abstract: This is the second iteration of the European Society of Cardiology (ESC) and European Association for the Study of Diabetes (EASD) joining forces to write guidelines on the management of diabetes mellitus (DM), pre-diabetes, and cardiovascular disease (CVD), designed to assist clinicians and other healthcare workers to make evidence-based management decisions. The growing awareness of the strong biological relationship between DM and CVD rightly prompted these two large organizations to collaborate to generate guidelines relevant to their joint interests, the first of which were published in 2007. Some assert that too many guidelines are being produced but, in this burgeoning field, five years in the development of both basic and clinical science is a long time and major trials have reported in this period, making it necessary to update the previous Guidelines.
Published: 2013

23. Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian Cardiac Outcomes Trial. ASCOT investigators

Author: Sever, P, Dahlöf, B, Poulter, N, Wedel, H, Beevers, G, Caulfield, M, Collins, R, Kjeldsen, SE, McInnes, G, Mehlsen, J, Nieminen, M, O'Brien, E, and Ostergren, J
Abstract: OBJECTIVE: To test the primary hypothesis that a newer antihypertensive treatment regimen (calcium channel blocker +/- an angiotensin converting enzyme inhibitor) is more effective than an older regimen (beta-blocker +/- a diuretic) in the primary prevention of coronary heart disease (CHD). To test a second primary hypothesis that a statin compared with placebo will further protect against CHD endpoints in hypertensive subjects with a total cholesterol < or = 6.5 mmol/l. DESIGN: Prospective, randomized, open, blinded endpoint trial with a double-blinded 2 x 2 factorial component. SETTING: Patients were recruited mainly from general practices. PATIENTS: Men and women aged 40-79 were eligible if their blood pressure was > or = 160 mmHg systolic or > or = 100 mmHg diastolic (untreated) or > or = 140 mmHg systolic or > or = 90 mmHg diastolic (treated) at randomization. INTERVENTIONS: Patients received either amlodipine (5/ 10 mg) +/- perindopril (4/8 mg) or atenolol (50/ 100 mg) +/- bendroflumethiazide (1.25/2.5 mg) +K+ with further therapy as required to reach a blood pressure of < or = 140 mmHg systolic and 90 mmHg diastolic. Patients with a total cholesterol of < or = 6.5 mmol/l were further randomized to receive either atorvastatin 10 mg or placebo daily. MAIN OUTCOME MEASURE: Non-fatal myocardial infarction (MI) and fatal coronary heart disease (CHD). RESULTS: 19 342 men and women were initially randomized, of these 10297 were also randomized into the lipid-lowering limb. All patients had three or more additional cardiovascular risk factors. CONCLUSIONS: The study has 80% power (at the 5% level) to detect a relative difference of 20% in CHD endpoints between the calcium channel blocker-based regimen and the beta-blocker-based regimen. The lipid-lowering limb of the study has 90% power at the 1% level to detect a relative difference of 30% in CHD endpoints between groups.
Published: 2001

24. Amino-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein but Not Cystatin C Predict Cardiovascular Events in Male Patients with Peripheral Artery Disease Independently of Ambulatory Pulse Pressure

Author: Skoglund, P. H., primary, Arpegard, J., additional, Ostergren, J., additional, and Svensson, P., additional
Published: 2014
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25. Predictors of blood pressure response to intensified and fixed combination treatment of hypertension: the ACCOMPLISH study

Author: Kjeldsen, S.E., Jamerson, K.A., Bakris, G.L., Pitt, B., Dahlof, B., Velazquez, E.J., Gupte, J., Staikos, L., Hua, T.A., Shi, V., Hester, A., Tuomilehto, J., Ostergren, J., Ibsen, H., Weber, M., Kjeldsen, S.E., Jamerson, K.A., Bakris, G.L., Pitt, B., Dahlof, B., Velazquez, E.J., Gupte, J., Staikos, L., Hua, T.A., Shi, V., Hester, A., Tuomilehto, J., Ostergren, J., Ibsen, H., and Weber, M.
Abstract: Udgivelsesdato: 2008
Published: 2008

26. Insuffisance cardiaque

Author: Meredith, PA, primary, Ostergren, J, additional, and Anand, I, additional
Published: 2009
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27. Regression of left ventricular hypertrophy in human hypertension with irbesartan

Author: Malmqvist, K., Kahan, T., Edner, M., Held, C., Hagg, A., Lind, L., Muller-Brunotte, R., Nyström, Fredrik, Ohman, K.P., Osbakken, M.D., Ostergren, J., Malmqvist, K., Kahan, T., Edner, M., Held, C., Hagg, A., Lind, L., Muller-Brunotte, R., Nyström, Fredrik, Ohman, K.P., Osbakken, M.D., and Ostergren, J.
Abstract: Background The Swedish irbesartan left ventricular hypertrophy investigation versus atenolol (SILVHIA). Objective Angiotensin II induces myocardial hypertrophy. We hypothesized that blockade of angiotensin II subtype 1 (AT1) receptors by the AT1-receptor antagonist irbesartan would reduce left ventricular mass (as measured by echocardiography) more than conventional treatment with a beta blocker. Design and methods This double-blind study randomized 115 hypertensive men and women with left ventricular hypertrophy to receive either irbesartan 150 mg q.d. or atenolol 50 mg q.d. for 48 weeks. If diastolic blood pressure remained above 90 mmHg, doses were doubled, and additional medications (hydrochlorothiazide and felodipine) were prescribed as needed. Echocardiography was performed at weeks 0, 12, 24 and 48. Results Baseline mean blood pressure was 162/104 mmHg, and mean left ventricular mass index was 157 g/m2 for men and 133 g/m2 for women. Systolic and diastolic blood pressure reductions were similar in both treatment groups. Both irbesartan (P < 0.001) and atenolol (P < 0.001) progressively reduced left ventricular mass index, e.g. by 26 and 14 g/m2 (16 and 9%), respectively, at week 48, with a greater reduction in the irbesartan group (P = 0.024). The proportion of patients who attained a normalized left ventricular mass (i.e. = 131 g/m2 for men and = 100 g/m2 for women) tended to be greater with irbesartan (47 versus 32%, P = 0.108). Conclusions Left ventricular mass was reduced more in the irbesartan group than in the atenolol group. These results suggest that blocking the action of angiotensin II at AT1 -receptors may be an important mechanism, beyond that of lowering blood pressure, in the regulation of left ventricular mass and geometry in patients with hypertension. © 2001 Lippincott Williams & Wilkins.
Published: 2001
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28. Anglo-Scandinavian Cardiac Outcomes Trial: a brief history, rationale and outline protocol

Author: Sever, P S, Dahlöf, B, Poulter, N R, Wedel, H, Beevers, G, Caulfield, M, Collins, R, Kjeldsen, S E, McInnes, G T, Mehlsen, J, Nieminen, M, O'Brien, E, Ostergren, J, Sever, P S, Dahlöf, B, Poulter, N R, Wedel, H, Beevers, G, Caulfield, M, Collins, R, Kjeldsen, S E, McInnes, G T, Mehlsen, J, Nieminen, M, O'Brien, E, and Ostergren, J
Published: 2001

29. Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian Cardiac Outcomes Trial. ASCOT investigators

Author: Sever, P S, Dahlöf, B, Poulter, N R, Wedel, H, Beevers, G, Caulfield, M, Collins, R, Kjeldsen, S E, McInnes, G T, Mehlsen, J, Nieminen, M, O'Brien, E, Ostergren, J, Sever, P S, Dahlöf, B, Poulter, N R, Wedel, H, Beevers, G, Caulfield, M, Collins, R, Kjeldsen, S E, McInnes, G T, Mehlsen, J, Nieminen, M, O'Brien, E, and Ostergren, J
Abstract: To test the primary hypothesis that a newer antihypertensive treatment regimen (calcium channel blocker +/- an angiotensin converting enzyme inhibitor) is more effective than an older regimen (beta-blocker +/- a diuretic) in the primary prevention of coronary heart disease (CHD). To test a second primary hypothesis that a statin compared with placebo will further protect against CHD endpoints in hypertensive subjects with a total cholesterol
Published: 2001

30. LIPID LOWERING EFFICACY OF ROSUVASTATIN VS ATORVASTATIN IN PATIENTS WITH CORONARY ARTERY DISEASE

Author: Ostergren, J., primary, Malmstrom, R., additional, Jorgensen, L., additional, and Walldius, G., additional
Published: 2008
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31. GUIDELINES ON DIABETES, PRE-DIABETES, AND CARDIOVASCULAR DISEASES

Author: Ryden, L., primary, Standl, E., additional, Bartnik, M., additional, Van den Berghe, G., additional, Betteridge, J., additional, De Boer, M.J., additional, Cosentino, F., additional, Jonsson, B., additional, Laakso, M., additional, Malmberg, K., additional, Priori, S., additional, Ostergren, J., additional, Tuomilehto, J., additional, and Thrainsdottir, I., additional
Published: 2007
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32. 119 Blood pressure in acute heart failure: relation to mortality at follow up

Author: SUNDBERG, H, primary, SVENSSON, P, additional, and OSTERGREN, J, additional
Published: 2006
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33. Effect of Amlodipine versus Felodipine extended release on 24-hour ambulatory blood pressure in hypertension

Author: Ostergren, J., Isaksson, U., Brodin, U., Schwan, Å., Ohman, K.P., Ostergren, J., Isaksson, U., Brodin, U., Schwan, Å., and Ohman, K.P.
Published: 1998

34. 594 Differences between diabetic and non-diabetic patients with chronic heart failure. Baseline demographics from CHARM

Author: OSTERGREN, J, primary, GRANGER, C, additional, HELD, P, additional, OLOFSSON, B, additional, PFEFFER, M, additional, MCMURRAY, J, additional, SWEDBERG, K, additional, YUSUF, S, additional, and MICHELSON, E, additional
Published: 2003
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35. 588 Differences between younger and older patients with chronic heart failure. Baseline demographics from CHARM

Author: SWEDBERG, K, primary, GRANGER, C, additional, HELD, P, additional, OLOFSSON, B, additional, MCMURRAY, J, additional, PFEFFER, M, additional, YUSUF, S, additional, OSTERGREN, J, additional, and MICHELSON, E, additional
Published: 2003
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36. 590 How do men and women with chronic heart failure differ? Baseline demographics from CHARM

Author: MCMURRAY, J, primary, GRANGER, C, additional, HELD, P, additional, OLOFSSON, B, additional, PFEFFER, M, additional, SWEDBERG, K, additional, YUSUF, S, additional, OSTERGREN, J, additional, and MICHELSON, E, additional
Published: 2003
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37. Main results of the losartan versus amlodipine (LOA) study on drug tolerability and psychological general well-being. LOA Study Group.

Author: Dahlöf B, Lindholm LH, Carney S, Pentikäinen PJ, Ostergren J, Dahlöf, B, Lindholm, L H, Carney, S, Pentikäinen, P J, and Ostergren, J
Published: 1997
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38. The cost-effectiveness of ramipril in the treatment of patients at high risk of cardiovascular events: a Swedish sub-study to the HOPE study

Author: Bjorholt, I., primary, Andersson, F. L., additional, Kahan, T., additional, and Ostergren, J., additional
Published: 2002
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39. Quality of life in hypertensive patients treated with either carvedilol or enalapril

Author: Ostergren, J., Storstein, L., Karlberg, B.E., Tibblin, G., Ostergren, J., Storstein, L., Karlberg, B.E., and Tibblin, G.
Published: 1996

40. Combined EXAFS and FTIR investigation of sulfate and carbonate effects on Pb(II) sorption to goethite (α-FeOOH)

Author: Ostergren, J. D., primary, Bargar, J. R., additional, Brown, G. E., additional, and Parks, G. A., additional
Published: 1999
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41. XAFS and XSW study of the distribution of Pb(II) sorbed to biofilms on α-Al2O3 and α-FeOOH surfaces

Author: Templeton, A. S., primary, Ostergren, J. D., additional, Trainor, T. P., additional, Foster, A. L., additional, Traina, S. J., additional, Spormann, A., additional, and Brown, G. E., additional
Published: 1999
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42. Transcutaneous oxygen tension and toe blood pressure as predictors for outcome of diabetic foot ulcers.

Author: Kalani, M, primary, Brismar, K, additional, Fagrell, B, additional, Ostergren, J, additional, and Jörneskog, G, additional
Published: 1999
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43. Insulin sensitivity predicts the response to antihypertensive therapy: a substudy to CAPPP.

Author: OSTERGREN, J, primary
Published: 1996
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44. Night and morning blood pressure is better controlled by amlodipine than felodipine

Author: OSTERGREN, J, primary
Published: 1996
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45. Influence of statin treatment on platelet inhibition by clopidogrel - a randomized comparison of rosuvastatin, atorvastatin and simvastatin co-treatment.

Author: Malmström RE, Ostergren J, Jørgensen L, Hjemdahl P, and CASTOR investigators
Abstract: OBJECTIVES: Possible interactions between clopidogrel and atorvastatin, simvastatin or rosuvastatin (a 'non-CYP3A4' metabolized statin) were investigated in a randomized prospective study using sensitive and specific ex vivo platelet function tests. METHODS: Patients with coronary artery disease participating in a double-blind study comparing lipid-lowering effects of atorvastatin (20-80 mg OD; n = 22) and rosuvastatin (10-40 mg OD; n = 24) were studied before and after 2 weeks treatment with clopidogrel 75 mg OD after completed statin dose titration. In addition, 23 patients were randomized to open-label simvastatin 40 mg OD. RESULTS: Clopidogrel inhibited 10 mumol L(-1) ADP-induced platelet aggregation by 40 +/- 27%, 57 +/- 28% and 51 +/- 29%, respectively, in patients on rosuvastatin, atorvastatin and simvastatin treatment. The other platelet tests yielded similar results. No dose-dependent effects of rosuvastatin or atorvastatin co-treatment on clopidogrel efficacy were observed. CONCLUSIONS: Treatment with CYP3A4 metabolized statins, atorvastatin or simvastatin, did not attenuate the platelet inhibitory effect of clopidogrel maintenance treatment compared with the non-CYP3A4 metabolized, rosuvastatin. [ABSTRACT FROM AUTHOR]
Published: 2009
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46. The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes.

Author: Ostergren J, Poulter NR, Sever PS, Dahlöf B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, ASCOT investigators, Ostergren, Jan, Poulter, Neil R, Sever, Peter S, Dahlöf, Björn, and Wedel, Hans
Published: 2008
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47. Sex differences in clinical characteristics and prognosis in a broad spectrum of patients with heart failure: results of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program.

Author: O'Meara E, Clayton T, McEntegart MB, McMurray JJ, Piña IL, Granger CB, Ostergren J, Michelson EL, Solomon SD, Pocock S, Yusuf S, Swedberg K, Pfeffer MA, and CHARM Investigators
Published: 2007

48. Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure: results of the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program.

Author: O'Meara E, Clayton T, McEntegart MB, McMurray JJ, Lang CC, Roger SD, Young JB, Solomon SD, Granger CB, Ostergren J, Olofsson B, Michelson EL, Pocock S, Yusuf S, Swedberg K, Pfeffer MA, and CHARM Committees and Investigators
Published: 2006

49. Renal function as a predictor of outcome in a broad spectrum of patients with heart failure.

Author: Hillege HL, Nitsch D, Pfeffer MA, Swedberg K, McMurray JJ, Yusuf S, Granger CB, Michelson EL, Ostergren J, Cornel JH, de Zeeuw D, Pocock S, van Veldhuisen DJ, and CHARM Investigators
Published: 2006

50. Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial--lipid-lowering arm (ASCOT-LLA).

Author: Sever PS, Poulter NR, Dahlöf B, Wedel H, Collins R, Beevers G, Caulfield M, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J, ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) Investigators, Sever, Peter S, Poulter, Neil R, Dahlöf, Björn, Wedel, Hans, and Collins, Rory
Abstract: Objective: This study aims to establish the benefits of lowering cholesterol in diabetic patients with well-controlled hypertension and average/below-average cholesterol concentrations, but without established coronary disease.Research Design and Methods: In the lipid-lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-LLA), 10,305 hypertensive patients with no history of coronary heart disease (CHD) but at least three cardiovascular risk factors were randomly assigned to receive 10 mg atorvastatin or placebo. Effects on total cardiovascular outcomes in 2,532 patients who had type 2 diabetes at randomization were compared.Results: During a median follow-up of 3.3 years, concentrations of total and LDL cholesterol among diabetic participants included in ASCOT-LLA were approximately 1 mmol/l lower in those allocated atorvastatin compared with placebo. There were 116 (9.2%) major cardiovascular events or procedures in the atorvastatin group and 151 (11.9%) events in the placebo group (hazard ratio 0.77, 95% CI 0.61-0.98; P = 0.036). For the individual components of this composite end point, the number of events occurring in the diabetes subgroup was small. Therefore, although fewer coronary events (0.84, 0.55-1.29; P = 0.14) and strokes (0.67, 0.41-1.09; P = 0.66) were observed among the patients allocated atorvastatin, these reductions were not statistically significant.Conclusions: Atorvastatin significantly reduced the risk of major cardiovascular events and procedures among diabetic patients with well-controlled hypertension and without a history of CHD or markedly elevated cholesterol concentrations. The proportional reduction in risk was similar to that among participants who did not have diagnosed diabetes. Allocation to atorvastatin prevented approximately 9 diabetic participants from suffering a first major cardiovascular event or procedure for every 1,000 treated for 1 year. [ABSTRACT FROM AUTHOR]
Published: 2005
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