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2. IFNL4 Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa.

Author

Baker, Francine, Wang, Jeanny, Florez-Vargas, Oscar, Brand, Nathan, Ogwang, Martin, Kerchan, Patrick, Reynolds, Steven, Tenge, Constance, Were, Pamela, Kuremu, Robert, Wekesa, Walter, Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Otim, Isaac, Legason, Ismail, Nabalende, Hadijah, Chagaluka, George, Mutalima, Nora, Borgstein, Eric, Liomba, George, Kamiza, Steve, Mkandawire, Nyengo, Mitambo, Collins, Molyneux, Elizabeth, Newton, Robert, Prokunina-Olsson, Ludmila, and Mbulaiteye, Sam

Subjects
Burkitt Lymphoma, IFNL4, genetic susceptibility, infection, interferon Lambda 4, Child, Preschool, Child, Humans, Burkitt Lymphoma, Genotype, Hepatitis C, Hepacivirus, Africa, Eastern, Interleukins, Polymorphism, Single Nucleotide
Abstract

Interferon lambda 4 (IFN-λ4) is a novel type-III interferon that can be expressed only by carriers of the genetic variant rs368234815-dG within the first exon of the IFNL4 gene. Genetic inability to produce IFN-λ4 (in carriers of the rs368234815-TT/TT genotype) has been associated with improved clearance of hepatitis C virus (HCV) infection. The IFN-λ4-expressing rs368234815-dG allele (IFNL4-dG) is most common (up to 78%) in West sub-Saharan Africa (SSA), compared to 35% of Europeans and 5% of individuals from East Asia. The negative selection of IFNL4-dG outside Africa suggests that its retention in African populations could provide survival benefits, most likely in children. To explore this hypothesis, we conducted a comprehensive association analysis between IFNL4 genotypes and the risk of childhood Burkitt lymphoma (BL), a lethal infection-associated cancer most common in SSA. We used genetic, epidemiologic, and clinical data for 4,038 children from the Epidemiology of Burkitt Lymphoma in East African Children and Minors (EMBLEM) and the Malawi Infections and Childhood Cancer case-control studies. Generalized linear mixed models fit with the logit link controlling for age, sex, country, P. falciparum infection status, population stratification, and relatedness found no significant association between BL risk and 3 coding genetic variants within IFNL4 (rs368234815, rs117648444, and rs142981501) and their combinations. Because BL occurs in children 6-9 years of age who survived early childhood infections, our results suggest that additional studies should explore the associations of IFNL4-dG allele in younger children. This comprehensive study represents an important baseline in defining the health effects of IFN-λ4 in African populations.

Published
2023

4. Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa

Author

Zhou, Weiyin, Fischer, Anja, Ogwang, Martin D., Luo, Wen, Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Otim, Isaac, Legason, Ismail D., Nabalende, Hadijah, Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Gouveia, Mateus H., Cole, Nathan, Hicks, Belynda, Jones, Kristine, Hummel, Michael, Schlesner, Mathias, Chagaluka, George, Mutalima, Nora, Borgstein, Eric, Liomba, George N., Kamiza, Steve, Mkandawire, Nyengo, Mitambo, Collins, Molyneux, Elizabeth M., Newton, Robert, Glaser, Selina, Kretzmer, Helene, Manning, Michelle, Hutchinson, Amy, Hsing, Ann W., Tettey, Yao, Adjei, Andrew A., Chanock, Stephen J., Siebert, Reiner, Yeager, Meredith, Prokunina-Olsson, Ludmila, Machiela, Mitchell J., and Mbulaiteye, Sam M.

Published
2023
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5. Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., Otim, Isaac, Ogwang, Martin D., Wang, Mingyi, Zhu, Bin, Cole, Nathan, Luo, Wen, Hicks, Belynda, Jones, Kristine, Oehl-Huber, Kathrin, Ayers, Leona W., Pittaluga, Stefania, Legason, Ismail D., Nabalende, Hadijah, Kerchan, Patrick, Kinyera, Tobias, Kawira, Esther, Brubaker, Glen, Levin, Arthur G., Guertler, Lutz, Kim, Jung, Stewart, Douglas R., Adde, Melissa, Magrath, Ian, Bergen, Andrew W., Reynolds, Steven J., Yeager, Meredith, Bhatia, Kishor, Adeyemo, Adebowale A., Prokunina-Olsson, Ludmila, Dean, Michael, Shriner, Daniel, Rotimi, Charles N., Chanock, Stephen, Siebert, Reiner, and Mbulaiteye, Sam M.

Published
2021
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6. Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma

Author

Liu, Zhiwei, primary, Luo, Yang, additional, Kirimunda, Samuel, additional, Verboom, Murielle, additional, Onabajo, Olusegun O., additional, Gouveia, Mateus H., additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Cole, Nathan, additional, Luo, Wen, additional, Liu, Jia, additional, Manning, Michelle, additional, Hicks, Belynda, additional, Prokunina-Olsson, Ludmila, additional, Chagaluka, George, additional, Johnston, W. Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N., additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth M., additional, Newton, Robert, additional, Hsing, Ann W., additional, Mensah, James E., additional, Adjei, Anthony A., additional, Hutchinson, Amy, additional, Carrington, Mary, additional, Yeager, Meredith, additional, Blasczyk, Rainer, additional, Chanock, Stephen J., additional, Raychaudhuri, Soumya, additional, and Mbulaiteye, Sam M., additional

Published
2024
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7. Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study

Author

Peprah, Sally, Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Otim, Isaac, Legason, Ismail D., Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Pfeiffer, Ruth M., and Mbulaiteye, Sam M.

Published
2021
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8. Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

Author

Derkach, Andriy, Otim, Isaac, Pfeiffer, Ruth M., Onabajo, Olusegun O., Legason, Ismail D., Nabalende, Hadijah, Ogwang, Martin D., Kerchan, Patrick, Talisuna, Ambrose O., Ayers, Leona W., Reynolds, Steven J., Nkrumah, Francis, Neequaye, Janet, Bhatia, Kishor, Theander, Thor G., Prokunina-Olsson, Ludmila, Turner, Louise, Goedert, James J., Lavstsen, Thomas, and Mbulaiteye, Sam M.

Published
2019
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9. Sickle cell allele HBB‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa

Author

Hong, Hyokyoung G., primary, Gouveia, Mateus H., additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Wang, Xunde, additional, Zhou, Jiefu, additional, Leal, Thiago Peixoto, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Mumia, Mediatrix, additional, Baker, Francine S., additional, Okusolubo, Temiloluwa, additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Woo, Joshua, additional, Manning, Michelle, additional, Cole, Nathan, additional, Luo, Wen, additional, Hicks, Belynda, additional, Chagaluka, George, additional, Johnston, W. Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N., additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth M., additional, Newton, Robert, additional, Hutchinson, Amy, additional, Yeager, Meredith, additional, Adeyemo, Adebowale A., additional, Thein, Swee Lay, additional, Rotimi, Charles N., additional, Chanock, Stephen J., additional, Prokunina‐Olsson, Ludmila, additional, and Mbulaiteye, Sam M., additional

Published
2023
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10. Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya

Author

Redmond, Lawrence S., Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Masalu, Nestory, Kawira, Esther, Otim, Isaac, Legason, Ismail D., Dhudha, Herry, Ayers, Leona W., Bhatia, Kishor, Goedert, James J., and Mbulaiteye, Sam M.

Published
2020
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11. Sickle cell allele HBB‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa.

Author

Hong, Hyokyoung G., Gouveia, Mateus H., Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Wang, Xunde, Zhou, Jiefu, Leal, Thiago Peixoto, Otim, Isaac, Legason, Ismail D., Nabalende, Hadijah, Dhudha, Herry, and Mumia, Mediatrix

Published
2024
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12. Author Correction to: Endemic Burkitt lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., Otim, Isaac, Ogwang, Martin D., Wang, Mingyi, Zhu, Bin, Cole, Nathan, Luo, Wen, Hicks, Belynda, Jones, Kristine, Oehl-Huber, Kathrin, Ayers, Leona W., Pittaluga, Stefania, Legason, Ismail D., Nabalende, Hadijah, Kerchan, Patrick, Kinyera, Tobias, Kawira, Esther, Brubaker, Glen, Levin, Arthur G., Guertler, Lutz, Kim, Jung, Stewart, Douglas R., Adde, Melissa, Magrath, Ian, Bergen, Andrew W., Reynolds, Steven J., Yeager, Meredith, Bhatia, Kishor, Adeyemo, Adebowale A., Prokunina-Olsson, Ludmila, Dean, Michael, Shriner, Daniel, Rotimi, Charles N., Chanock, Stephen, Siebert, Reiner, and Mbulaiteye, Sam M.

Published
2021
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13. Burkitt lymphoma risk shows geographic and temporal associations with Plasmodium falciparum infections in Uganda, Tanzania, and Kenya

Author

Broen, Kelly, primary, Dickens, Joey, additional, Trangucci, Rob, additional, Ogwang, Martin D., additional, Tenge, Constance N., additional, Masalu, Nestory, additional, Reynolds, Steven J., additional, Kawira, Esther, additional, Kerchan, Patrick, additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadija, additional, Buller, Ian D., additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Biggar, Robert J., additional, Goedert, James J., additional, Wilson, Mark L., additional, Mbulaiteye, Sam M., additional, and Zelner, Jon, additional

Published
2023
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14. Increased Frequency of Mosaic Chromosomal Alterations in Peripheral Blood Samples of Sub-Saharan African Children with Endemic Burkitt Lymphoma

Author

Zhou, Weiyin, primary, Pfaus, Anja, additional, Ogwang, Martin, additional, Luo, Wen, additional, Kerchan, Patrick, additional, Reynolds, Steven, additional, Tenge, Constance N, additional, Were, Pamela A, additional, Kuremu, Robert T, additional, Wekesa, Walter N, additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D, additional, Nabalende, Hadijah, additional, Ayers, Leona W, additional, Bhatia, Kishor, additional, Goedert, James J, additional, Cole, Nathan, additional, Hicks, Belynda, additional, Jones, Kristine, additional, Hummel, Michael, additional, Schlesner, Matthias, additional, Chagaluka, George, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N, additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth, additional, Newton, Robert, additional, Glaser, Selina, additional, Manning, Michelle, additional, Hutchinson, Amy, additional, Hsing, Ann W, additional, Tettey, Yao, additional, Adjei, Andrew Anthony, additional, Chanock, Stephen J., additional, Siebert, Reiner, additional, Yeager, Meredith, additional, Machiela, Mitchell, additional, and Mbulaiteye, Sam M., additional

Published
2022
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15. Human Leukocyte Antigen Contributes to Childhood Endemic Burkitt Lymphoma in Eastern Africa: A Case-Control Association Study

Author

Liu, Zhiwei, primary, Luo, Yang, additional, Kirimunda, Samuel, additional, Verboom, Murielle, additional, Onabajo, Olusegun O, additional, Gouveia, Mateus H, additional, Ogwang, Martin, additional, Kerchan, Patrick, additional, Reynolds, Steven, additional, Tenge, Constance N, additional, Were, Pamela A, additional, Kuremu, Robert T, additional, Wekesa, Walter N, additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D, additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Ayers, Leona W, additional, Biggar, Robert J, additional, Bhatia, Kishor G., additional, Goedert, James J, additional, Cole, Nathan, additional, Luo, Wen, additional, Liu, Jia, additional, Manning, Michelle, additional, Hicks, Belynda, additional, Prokunina-Olsson, Ludmila, additional, Chagaluka, George, additional, Johnston, Tom, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N, additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth, additional, Newton, Robert, additional, Hsing, Ann W, additional, Mensah, James E, additional, Pfeiffer, Ruth M, additional, Hutchinson, Amy, additional, Mary, Carrington, additional, Yeager, Meredith, additional, Joloba, Moses, additional, Blasczyk, Rainer, additional, Chanock, Stephen J., additional, Raychaudhuri, Soumya, additional, and Mbulaiteye, Sam M., additional

Published
2022
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16. HBB rs334, ABO R s8176703 and Plasmodium Falciparum Positivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Author

Hong, Hyokyoung G, primary, Gouveia, Mateus H, additional, Ogwang, Martin, additional, Kerchan, Patrick, additional, Reynolds, Steven, additional, Tenge, Constance N, additional, Were, Pamela A, additional, Kuremu, Robert T, additional, Wekesa, Walter N, additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Wang, Xunde, additional, Zhou, Jiefu, additional, Otim, Isaac, additional, Legason, Ismail D, additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Mumia, Mediatrix, additional, Baker, Francine G, additional, Okusolubo, Temi, additional, Ayers, Leona W, additional, Bhatia, Kishor, additional, Goedert, James J, additional, Woo, Joshua G, additional, Cole, Nathan, additional, Luo, Wen, additional, Hicks, Belynda, additional, Adeyemo, Adebowale A, additional, Prokunina-Olsson, Ludmila, additional, Shriner, Daniel N., additional, Rotimi, Charles N, additional, Chagaluka, George, additional, Johnston, W Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N, additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth, additional, Newton, Robert, additional, Manning, Michelle, additional, Fraumeni, Joseph F, additional, Pfeiffer, Ruth M, additional, Hutchinson, Amy, additional, Yeager, Meredith, additional, Thein, Swee Lay, additional, Chanock, Stephen J., additional, and Mbulaiteye, Sam M., additional

Published
2022
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18. HBB rs334, ABO Rs8176703 and Plasmodium Falciparum Positivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Author

Hong, Hyokyoung G, Gouveia, Mateus H, Ogwang, Martin, Kerchan, Patrick, Reynolds, Steven, Tenge, Constance N, Were, Pamela A, Kuremu, Robert T, Wekesa, Walter N, Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Wang, Xunde, Zhou, Jiefu, Otim, Isaac, Legason, Ismail D, Nabalende, Hadijah, Dhudha, Herry, Mumia, Mediatrix, Baker, Francine G, Okusolubo, Temi, Ayers, Leona W, Bhatia, Kishor, Goedert, James J, Woo, Joshua G, Cole, Nathan, Luo, Wen, Hicks, Belynda, Adeyemo, Adebowale A, Prokunina-Olsson, Ludmila, Shriner, Daniel N., Rotimi, Charles N, Chagaluka, George, Johnston, W Thomas, Mutalima, Nora, Borgstein, Eric, Liomba, George N, Kamiza, Steve, Mkandawire, Nyengo, Mitambo, Collins, Molyneux, Elizabeth, Newton, Robert, Manning, Michelle, Fraumeni, Joseph F, Jr., Pfeiffer, Ruth M, Hutchinson, Amy, Yeager, Meredith, Thein, Swee Lay, Chanock, Stephen J., and Mbulaiteye, Sam M.

Published
2022
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19. Epstein-Barr Virus in Burkitt Lymphoma in Africa Reveals a Limited Set of Whole Genome and LMP-1 Sequence Patterns: Analysis of Archival Datasets and Field Samples From Uganda, Tanzania, and Kenya

Author

Liao, Hsiao-Mei, primary, Liu, Hebing, additional, Chin, Pei-Ju, additional, Li, Bingjie, additional, Hung, Guo-Chiuan, additional, Tsai, Shien, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Ogwang, Martin D., additional, Reynolds, Steven J., additional, Kerchan, Patrick, additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Ayers, Leona W., additional, Pfeiffer, Ruth M., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Lo, Shyh-Ching, additional, and Mbulaiteye, Sam M., additional

Published
2022
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20. Plasma EBV DNA: A Promising Diagnostic Marker for Endemic Burkitt Lymphoma

Author

Xian, Rena R., primary, Kinyera, Tobias, additional, Otim, Isaac, additional, Sampson, Joshua N., additional, Nabalende, Hadijah, additional, Legason, Ismail D., additional, Stone, Jennifer, additional, Ogwang, Martin D., additional, Reynolds, Steven J., additional, Kerchan, Patrick, additional, Bhatia, Kishor, additional, Goedert, James J., additional, Mbulaiteye, Sam M., additional, and Ambinder, Richard F., additional

Published
2021
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21. Additional file 1 of Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study

Author

Peprah, Sally, Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Otim, Isaac, Legason, Ismail D., Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Pfeiffer, Ruth M., and Mbulaiteye, Sam M.

Abstract

Additional file 1: Supplementary Table 1. Questionnaire variables/data elements and how they were coded for exploratory factor analysis. Supplementary Table 2. Eigenvalue and variance explained by extracted factors shown for each imputed dataset and by study country. Supplementary Table 3. Odds ratios and 95% confidence intervals (CIs) of the association of factors with falciparum infection risk in controls, by country. Supplementary Table 4. Odds ratios and 95% confidence intervals (CIs) of the association of factors with eBL risk, by country.

Published
2021
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22. Genomic Landscape of Epstein-Barr Virus in Endemic Burkitt Lymphoma

Author

Legason, Ismail D, Burns, Adam, Ridout, Kate, Jennings, Daisy, Ogwang, Martin D, Otim, Isaac, Nabalende, Hadijah, Achola, Caroline, Ayitewala, Alisen, Sseruyange, Julius, Chamba, Clara C, Josephat, Emmanuel, Christopher, Heavenlight, Mawalla, William F, Mkwizu, Elifurah, Mremi, Alex, Mwamtemi, Hadija, Dreau, Helene, El Mouden, Claire, Vavoulis, Dimitris, Leung, Carol Sze, and Schuh, Anna

Published
2023
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25. Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., primary, Otim, Isaac, additional, Ogwang, Martin D., additional, Wang, Mingyi, additional, Zhu, Bin, additional, Cole, Nathan, additional, Luo, Wen, additional, Hicks, Belynda, additional, Jones, Kristine, additional, Oehl-Huber, Kathrin, additional, Ayers, Leona W., additional, Pittaluga, Stefania, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Kerchan, Patrick, additional, Kinyera, Tobias, additional, Kawira, Esther, additional, Brubaker, Glen, additional, Levin, Arthur G., additional, Guertler, Lutz, additional, Kim, Jung, additional, Stewart, Douglas R., additional, Adde, Melissa, additional, Magrath, Ian, additional, Bergen, Andrew W., additional, Reynolds, Steven J., additional, Yeager, Meredith, additional, Bhatia, Kishor, additional, Adeyemo, Adebowale A., additional, Prokunina-Olsson, Ludmila, additional, Dean, Michael, additional, Shriner, Daniel, additional, Rotimi, Charles N., additional, Chanock, Stephen, additional, Siebert, Reiner, additional, and Mbulaiteye, Sam M., additional

Published
2020
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26. Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya

Author

Peprah, Sally, primary, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N, additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Mumia, Mediatrix, additional, Ayers, Leona W., additional, Biggar, Robert J., additional, Bhatia, Kishor, additional, Goedert, James J., additional, and Mbulaiteye, Sam M., additional

Published
2020
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27. Variation in the Human Leukocyte Antigen system and risk for endemic Burkitt lymphoma in northern Uganda

Author

Kirimunda, Samuel, primary, Verboom, Murielle, additional, Otim, Isaac, additional, Ssennono, Mark, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Kinyera, Tobias, additional, Mwebaza, Ivan, additional, Joloba, Moses, additional, Ayers, Leona W., additional, Reynolds, Steven J., additional, Bhatia, Kishor, additional, Onabajo, Olusegun O., additional, Hallensleben, Michael, additional, Biggar, Robert J., additional, Prokunina‐Olsson, Ludmila, additional, Goedert, James J., additional, Blasczyk, Rainer, additional, and Mbulaiteye, Sam M., additional

Published
2020
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29. MOESM1 of A cross-sectional study of asymptomatic Plasmodium falciparum infection burden and risk factors in general population children in 12 villages in northern Uganda

Author

Maziarz, Marlena, Hadijah Nabalende, Otim, Isaac, Legason, Ismail, Kinyera, Tobias, Ogwang, Martin, Talisuna, Ambrose, Reynolds, Steven, Kerchan, Patrick, Kishor Bhatia, Biggar, Robert, Goedert, James, Pfeiffer, Ruth, and Mbulaiteye, Sam

Abstract

Additional file 1: Table S1. Weighted distribution of characteristics of apparently healthy children aged 0â 15Â years enrolled between October 2011 and February 2014 in 12 villages in northern Uganda.

Published
2018
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30. Risk factors for Burkitt lymphoma in East African children and minors: A case–control study in malaria‐endemic regions in Uganda, Tanzania and Kenya

Author

Peprah, Sally, primary, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Sumba, Peter O., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Magatti, Josiah, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Ally, Hillary, additional, Genga, Isaiah O., additional, Mumia, Mediatrix, additional, Ayers, Leona W., additional, Pfeiffer, Ruth M., additional, Biggar, Robert J., additional, Bhatia, Kishor, additional, Goedert, James J., additional, and Mbulaiteye, Sam M., additional

Published
2019
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31. Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"

Author

Gouveia, Mateus H., primary, Bergen, Andrew W., additional, Borda, Victor, additional, Nunes, Kelly, additional, Leal, Thiago P., additional, Ogwang, Martin D., additional, Yeboah, Edward D., additional, Mensah, James E., additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Nabalende, Hadijah, additional, Legason, Ismail D., additional, Mpoloka, Sununguko Wata, additional, Mokone, Gaonyadiwe George, additional, Kerchan, Patrick, additional, Bhatia, Kishor, additional, Reynolds, Steven J., additional, Birtwum, Richard B., additional, Adjei, Andrew A., additional, Tettey, Yao, additional, Tay, Evelyn, additional, Hoover, Robert, additional, Pfeiffer, Ruth M., additional, Biggar, Robert J., additional, Goedert, James J., additional, Prokunina-Olsson, Ludmila, additional, Dean, Michael, additional, Yeager, Meredith, additional, Lima-Costa, M. Fernanda, additional, Hsing, Ann W., additional, Tishkoff, Sarah A., additional, Chanock, Stephen J., additional, Tarazona-Santos, Eduardo, additional, and Mbulaiteye, Sam M., additional

Published
2019
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32. A Cross-Sectional Population Study of Geographic, Age-Specific, and Household Risk Factors for Asymptomatic Plasmodium falciparum Malaria Infection in Western Kenya

Author

Peprah, Sally, primary, Tenge, Constance, additional, Genga, Isaiah O., additional, Mumia, Mediatrix, additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Sumba, Peter O., additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Biddle, Joshua, additional, Reynolds, Steven J., additional, Talisuna, Ambrose O., additional, Biggar, Robert J., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Pfeiffer, Ruth M., additional, and Mbulaiteye, Sam M., additional

Published
2019
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33. Improving the accuracy of heart failure diagnosis in low-resource settings through task sharing and decentralization

Author

DeWyer, Alyssa, primary, Scheel, Amy, additional, Otim, Isaac Omara, additional, Longenecker, Christopher T., additional, Okello, Emmy, additional, Ssinabulya, Isaac, additional, Morris, Stephen, additional, Okwir, Mark, additional, Oyang, William, additional, Joyce, Erine, additional, Nabongo, Betty, additional, Sable, Craig, additional, Alencherry, Ben, additional, Tompsett, Alison, additional, Aliku, Twalib, additional, and Beaton, Andrea, additional

Published
2019
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34. HBB rs334, ABO Rs8176703and Plasmodium FalciparumPositivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Author

Hong, Hyokyoung G, Gouveia, Mateus H, Ogwang, Martin, Kerchan, Patrick, Reynolds, Steven, Tenge, Constance N, Were, Pamela A, Kuremu, Robert T, Wekesa, Walter N, Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Wang, Xunde, Zhou, Jiefu, Otim, Isaac, Legason, Ismail D, Nabalende, Hadijah, Dhudha, Herry, Mumia, Mediatrix, Baker, Francine G, Okusolubo, Temi, Ayers, Leona W, Bhatia, Kishor, Goedert, James J, Woo, Joshua G, Cole, Nathan, Luo, Wen, Hicks, Belynda, Adeyemo, Adebowale A, Prokunina-Olsson, Ludmila, Shriner, Daniel N., Rotimi, Charles N, Chagaluka, George, Johnston, W Thomas, Mutalima, Nora, Borgstein, Eric, Liomba, George N, Kamiza, Steve, Mkandawire, Nyengo, Mitambo, Collins, Mitambo, Collins, Molyneux, Elizabeth, Newton, Robert, Manning, Michelle, Fraumeni, Joseph F, Pfeiffer, Ruth M, Hutchinson, Amy, Yeager, Meredith, Thein, Swee Lay, Chanock, Stephen J., and Mbulaiteye, Sam M.

Published
2022
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35. MOESM1 of Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda

Author

Maziarz, Marlena, Kinyera, Tobias, Otim, Isaac, Kagwa, Paul, Hadijah Nabalende, Legason, Ismail, Ogwang, Martin, Kirimunda, Samuel, Emmanuel, Benjamin, Reynolds, Steven, Kerchan, Patrick, Joloba, Moses, Bergen, Andrew, Kishor Bhatia, Talisuna, Ambrose, Biggar, Robert, Goedert, James, Pfeiffer, Ruth, and Mbulaiteye, Sam

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2017
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36. Risk factors for Burkitt lymphoma in East African children and minors: A case–control study in malaria‐endemic regions in Uganda, Tanzania and Kenya.

Author

Peprah, Sally, Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Sumba, Peter O., Masalu, Nestory, Kawira, Esther, Magatti, Josiah, Kinyera, Tobias, Otim, Isaac, Legason, Ismail D., Nabalende, Hadijah, Dhudha, Herry, Ally, Hillary, Genga, Isaiah O., and Mumia, Mediatrix

Subjects
BURKITT'S lymphoma, MALARIA, HIV seroconversion, CASE-control method, HIV infections, GLUCOSE-6-phosphate dehydrogenase deficiency
Abstract

Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in sub‐Saharan African countries, however, few epidemiologic studies have been undertaken and none attempted enrolling cases from multiple countries. We therefore conducted a population‐based case–control study of eBL in children aged 0–15 years old in six regions in Northern Uganda, Northern Tanzania and Western Kenya, enrolling 862 suspected cases and 2,934 population controls (response rates 98.5–100%), and processing ~40,000 vials of samples using standardized protocols. Risk factor questionnaires were administered, and malaria period prevalence was measured using rapid diagnostic tests (RDTs). A total of 80.9% of the recruited cases were diagnosed as eBL; 61.4% confirmed by histology. Associations with eBL risk were computed using logistic regression models adjusted for relevant confounders. Associations common in at least two countries were emphasized. eBL risk was decreased with higher maternal income and paternal education and elevated with history of inpatient malaria treatment >12 months before enrollment. Reporting malaria‐attributed fever up to 6 months before enrollment and malaria‐RDT positivity at enrollment were associated with decreased eBL risk. Conversely, reporting exposure to mass malaria suppression programs (e.g., indoor residual insecticide) was associated with elevated risk. HIV seropositivity was associated with elevated eBL risk, but the relative impact was small. The study shows that it is feasible to conduct networked, multisite population‐based studies of eBL in Africa. eBL was inversely associated with socioeconomic status, positively associated with inpatient malaria treatment 12 months ago and with living in areas targeted for malaria suppression, which support a role of malaria in eBL. What's new? Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in sub‐Saharan Africa, but there have been few epidemiologic studies. In this multi‐country analysis, the authors used harmonized protocols to investigate infectious, environmental, and other risk factors for eBL. Socioeconomic status and recent malarial fever were associated with reduced eBL risk, while HIV infection, previous malaria, and living in areas targeted for malaria suppression increased eBL risk. These results provide new baseline data regarding eBL epidemiology, indicating that malaria may play a role. They also confirm the feasibility of multi‐site, population‐based enrolment for crucial future eBL studies. [ABSTRACT FROM AUTHOR]

Published
2020
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37. Erratum to “Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda” [Cancer Epidemiol. 52 (2018) 70–74]

Author

Ravell, Juan, primary, Otim, Isaac, additional, Nabalende, Hadijah, additional, Legason, Ismail D., additional, Reynolds, Steven J., additional, Ogwang, Martin D., additional, Ndugwa, Christopher M., additional, Marshall, Vickie, additional, Whitby, Denise, additional, Goedert, James J., additional, Engels, Eric A., additional, Bhatia, Kishor, additional, Lenardo, Michael J., additional, and Mbulaiteye, Sam M., additional

Published
2018
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39. Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda

Author

Maziarz, Marlena, Kinyera, Tobias, Otim, Isaac, Kagwa, Paul, Nabalende, Hadijah, Legason, Ismail, Ogwang, Martin, Kirimunda, Samuel, Emmanuel, Benjamin, Reynolds, Steven, Kerchan, Patrick, Joloba, Moses, Bergen, Andrew, Bhatia, Kishor, Talisuna, Ambrose, Biggar, Bob, Goedert, James, Pfeiffer, Ruth, Mbulaiteye, Sam, Maziarz, Marlena, Kinyera, Tobias, Otim, Isaac, Kagwa, Paul, Nabalende, Hadijah, Legason, Ismail, Ogwang, Martin, Kirimunda, Samuel, Emmanuel, Benjamin, Reynolds, Steven, Kerchan, Patrick, Joloba, Moses, Bergen, Andrew, Bhatia, Kishor, Talisuna, Ambrose, Biggar, Bob, Goedert, James, Pfeiffer, Ruth, and Mbulaiteye, Sam

Published
2017

40. Evaluating the Causal Link Between Malaria Infection and Endemic Burkitt Lymphoma in Northern Uganda: A Mendelian Randomization Study

Author

Legason, Ismail D., primary, Pfeiffer, Ruth M., additional, Udquim, Krizia-Ivana, additional, Bergen, Andrew W., additional, Gouveia, Mateus H., additional, Kirimunda, Samuel, additional, Otim, Isaac, additional, Karlins, Eric, additional, Kerchan, Patrick, additional, Nabalende, Hadijah, additional, Bayanjargal, Ariunaa, additional, Emmanuel, Benjamin, additional, Kagwa, Paul, additional, Talisuna, Ambrose O., additional, Bhatia, Kishor, additional, Yeager, Meredith, additional, Biggar, Robert J., additional, Ayers, Leona W., additional, Reynolds, Steven J., additional, Goedert, James J., additional, Ogwang, Martin D., additional, Fraumeni, Joseph F., additional, Prokunina-Olsson, Ludmila, additional, and Mbulaiteye, Sam M., additional

Published
2017
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41. Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda

Author

Maziarz, Marlena, primary, Kinyera, Tobias, additional, Otim, Isaac, additional, Kagwa, Paul, additional, Nabalende, Hadijah, additional, Legason, Ismail D., additional, Ogwang, Martin D., additional, Kirimunda, Samuel, additional, Emmanuel, Benjamin, additional, Reynolds, Steven J., additional, Kerchan, Patrick, additional, Joloba, Moses M., additional, Bergen, Andrew W., additional, Bhatia, Kishor, additional, Talisuna, Ambrose O., additional, Biggar, Robert J., additional, Goedert, James J., additional, Pfeiffer, Ruth M., additional, and Mbulaiteye, Sam M., additional

Published
2017
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42. A cross-sectional study of asymptomatic <italic>Plasmodium falciparum</italic> infection burden and risk factors in general population children in 12 villages in northern Uganda.

Author

Maziarz, Marlena, Nabalende, Hadijah, Otim, Isaac, Legason, Ismail D., Kinyera, Tobias, Ogwang, Martin D., Talisuna, Ambrose O., Reynolds, Steven J., Kerchan, Patrick, Bhatia, Kishor, Biggar, Robert J., Goedert, James J., Pfeiffer, Ruth M., and Mbulaiteye, Sam M.

Subjects
PLASMODIUM falciparum, EPIDEMIOLOGY, MALARIA, LYMPHOMAS, MICROSCOPY
Abstract

Background: Plasmodium falciparum malaria is an important cause of morbidity in northern Uganda. This study was undertaken to assess village-, household-, and individual-level risk factors of asymptomatic falciparum malaria in children in 12 villages in northern Uganda. Methods: Between 10/2011 and 02/2014, 1006 apparently healthy children under 16 years old were enrolled in 12 villages using a stratified, multi-stage, cluster survey design and assessed for P. falciparum malaria infection using the rapid diagnostic test (RDT) and thick film microscopy (TFM), and structured interviewer-administered questionnaires. Associations between weighted P. falciparum malaria prevalence (pfPR), based on RDT, and covariates were estimated as odds ratios and 95% confidence intervals (ORs, 95% CIs) using logistic models accounting for the survey design. Results: Among 942 (93.5%) children successfully tested, pfPR was 52.4% by RDT and 32.7% by TFM. Overall pfPR was lower in villages where indoor residual insecticide spray (IRS) was, versus not, implemented (18.4% versus 75.2%, P < 0.0001). However, pfPR was heterogeneous both within IRS (10.6–34.8%) and non-IRS villages (63.6–86.2%). Elevated pfPR was associated with having a sibling who was RDT positive (OR 5.39, 95% CI 2.94–9.90, P = 0.0006) and reporting a fever at enrollment (aOR 4.80, 95% CI 1.94–11.9, P = 0.0094). Decreased pfPR was associated with living in an IRS village (adjusted OR 0.06, 95% CI 0.04–0.07, P < 0.0001), in a household with one (aOR 0.48, 95% CI 0.30–0.76) or more than one child below 5 years (aOR 0.23, 95% CI 0.12–0.44, Ptrend = 0.014), and reporting keeping a goat inside or near the house (aOR 0.42, 95% CI 0.29–0.62, P = 0.0021). Conclusions: The results show high but heterogeneous pfPR in villages in northern Uganda, confirm significantly decreased pfPR associated with IRS implementation, and suggest significant associations with some household characteristics. Further research is needed to elucidate the factors influencing malaria heterogeneity in villages in Uganda. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Previous Traditional Medicine Use for Sore Throat among Children Evaluated for Rheumatic Fever in Northern Uganda.

Author

Stein E, Pulle J, Zimmerman M, Otim I, Atala J, Rwebembera J, Oyella LM, Harik N, Okello E, Sable C, and Beaton A

Subjects
Adolescent, Child, Female, Humans, Male, Pharyngitis complications, Rheumatic Fever etiology, Tonsillectomy methods, Uganda, Medicine, African Traditional, Patient Acceptance of Health Care ethnology, Patient Acceptance of Health Care statistics & numerical data, Pharyngitis therapy, Rheumatic Fever diagnosis
Abstract

Timely diagnosis of group A streptococcal (GAS) sore throat coupled with appropriate antibiotic treatment is necessary to prevent serious post-streptococcal complications, including rheumatic fever (RF) and rheumatic heart disease (RHD). Traditional medicine (TM) is a known common adjunct to formal medical care in sub-Saharan Africa. A better understanding of health-seeking behavior for sore throat both within and outside the formal medical system is critical to improving primary prevention efforts of RF and RHD. A prospective mixed-methods study on the use of TM for sore throat was embedded within a larger epidemiological study of RF in Northern Uganda. Children presenting with symptoms of RF were interviewed about recent TM use as well as health services use for sore throat. One hundred children with a median age of 10 years (interquartile range: 6.8-13 years) completed the TM interview with their parent/guardian as part of a research study of RF. Seventeen, or 17%, accessed a TM provider for sore throat as part of the current illness, and 70% accessed TM for sore throat in the past (73% current or past use). Of the 20 parents who witnessed the TM visit, 100% reported use of crude tonsillectomy. Penicillin was the most frequently prescribed medication by TM providers in 52% of participants who were seen by a TM provider. The use of TM among children presenting with symptoms of sore throat in northern Uganda is common and frequently used in tandem with diagnostic services offered through the formal healthcare system. Engagement with TM practitioners may provide an important avenue for designing effective primary prevention and management strategies of RF and reduce the global burden of RHD.

Published
2020
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44. Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda.

Author

Ravell J, Otim I, Nabalende H, Legason ID, Reynolds SJ, Ogwang MD, Ndugwa CM, Marshall V, Whitby D, Goedert JJ, Engels EA, Bhatia K, Lenardo MJ, and Mbulaiteye SM

Subjects
Adolescent, Adult, Burkitt Lymphoma diagnosis, Burkitt Lymphoma epidemiology, Child, Child, Preschool, Epstein-Barr Virus Infections virology, Female, Humans, Infant, Infant, Newborn, Male, Uganda epidemiology, Young Adult, Burkitt Lymphoma blood, Burkitt Lymphoma virology, Epstein-Barr Virus Infections complications, Herpesvirus 4, Human pathogenicity, Magnesium blood, Viral Load
Abstract

Background: Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg 2+ ) supplementation in XMEN, an X-linked genetic disease associated with Mg 2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg 2+ levels and EBV levels and eBL in Uganda., Methods: Plasma Mg 2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg 2+ uptake by T-lymphocytes was evaluated in samples from healthy donors., Results: Plasma Mg 2+ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14-60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32-9.88), controlling for sex, age group, and malaria status. Mg 2+ uptake by T-lymphocytes was related to extracellular Mg 2+ concentration., Interpretation: Plasma Mg 2+ deficiency is associated with high EBV levels and eBL., (Published by Elsevier Ltd.)

Published
2018
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