Search

Your search keyword '"Ou, Yimeng"' showing total 13 results
Start Over Author "Ou, Yimeng"
13 results on '"Ou, Yimeng"'

3. Establishment of a prognostic model based on m6A regulatory factors and stemness of hepatocellular carcinoma using RNA-seq data and scRNA-seq data.

Author

Liang, Yan, Chen, Sen, Xie, Jinghe, Yan, Guanrong, Guo, Tingting, Li, Tianyang, Liu, Shoupei, Zeng, Weiping, Zhang, Shuai, Ma, Keqiang, Chen, Honglin, Ou, Yimeng, Wang, Bailin, Gu, Weili, and Duan, Yuyou

Subjects
PROGNOSTIC models, STEM cell factor, CANCER prognosis, CANCER stem cells, RNA sequencing
Abstract

Background: Hepatocellular carcinoma (HCC) with high incidence and mortality is one of the most common malignant cancers worldwide. Increasing evidence has reported that N6-methyladenosine (m6A) modification has been considered as a major contribution to the occurrence and development of tumors. Method: In our study, we comprehensively analyzed the connection between m6A regulatory factors and cancer stem cells (CSCs) of HCC to establish a clinical tool for predicting its outcome. First, we concluded that the expression level of m6A regulatory factors was related with the stemness of hepatocellular carcinoma. Subsequently, we gained a ten hub regulatory factors that were associated with prognosis of hepatocellular carcinoma by overall survival (OS) analysis using ICGC and TCGA datasets, and these regulatory factors included YTHDF1, IGF2BP1, METTL3, IGF2BP3, HNRNPA2B1, IGF2BP2, RBM15B, HNRNPC, RBMX, and LRPPR. Next, we found that these ten hub m6A regulatory factors were highly expressed in CSCs, and CSCs related pathways were also enriched by the gene set variation analysis (GSVA). Then, correlation, consensus clustering and PCA analysis were performed to reveal potential therapeutic benefits of HCC. Moreover, univariate Cox regression (UNICOX), LASSON and multivariate Cox regression (MULTICOX) analyses were adopted to establish HCC prognosis prediction signature. Results: Four regulatory factors RBM15B, LRPPRC, IGF2BP1, and IGF2BP3 were picked as valuable prognostic indicators. Conclusion: In summary, these ten hub regulatory factors would be useful therapeutic targets for HCC treatment, and RBM15B/LRPPRC/IGF2BP1/IGF2BP3 prognostic indicators can be used to guide therapy for HCC patients. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

5. ITGB1 Drives Hepatocellular Carcinoma Progression by Modulating Cell Cycle Process Through PXN/YWHAZ/AKT Pathways

Author

Xie, Jinghe, primary, Guo, Tingting, additional, Zhong, Zhiyong, additional, Wang, Ning, additional, Liang, Yan, additional, Zeng, Weiping, additional, Liu, Shoupei, additional, Chen, Qicong, additional, Tang, Xianglian, additional, Wu, Haibin, additional, Zhang, Shuai, additional, Ma, Keqiang, additional, Wang, Bailin, additional, Ou, Yimeng, additional, Gu, Weili, additional, Chen, Honglin, additional, Qiu, Yaqi, additional, and Duan, Yuyou, additional

Published
2021
Full Text
View/download PDF

6. The timing of laparoscopic cholecystectomy and nano-ligation clip for acute calculous cholecystitis under guidance of Tokyo guidelines 2018 (multi-center retrospective analysis)

Author

Wu, Hongsheng, primary, Ma, Keqiang, additional, Yu, Lei, additional, Gu, Weili, additional, Yan, Yong, additional, Wang, Bailin, additional, Yu, Jiongbiao, additional, Ou, Yimeng, additional, Yu, Haitao, additional, Liu, Yue, additional, Zhou, Yanyuan, additional, Huang, Guangrong, additional, and Cao, Tiansheng, additional

Published
2021
Full Text
View/download PDF

8. 3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway

Author

Wang, Ning, primary, Li, Xiajing, additional, Zhong, Zhiyong, additional, Qiu, Yaqi, additional, Liu, Shoupei, additional, Wu, Haibin, additional, Tang, Xianglian, additional, Chen, Chuxin, additional, Fu, Yingjie, additional, Chen, Qicong, additional, Guo, Tingting, additional, Li, Jinsong, additional, Zhang, Shuai, additional, Zern, Mark A, additional, Ma, Keqing, additional, Wang, Bailin, additional, Ou, Yimeng, additional, Gu, Weili, additional, Cao, Jie, additional, Chen, Honglin, additional, and Duan, Yuyou, additional

Published
2021
Full Text
View/download PDF

9. Additional file 1 of 3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGF��RII-SMADS pathway

Author

Wang, Ning, Li, Xiajing, Zhong, Zhiyong, Qiu, Yaqi, Liu, Shoupei, Wu, Haibin, Tang, Xianglian, Chen, Chuxin, Fu, Yingjie, Chen, Qicong, Guo, Tingting, Li, Jinsong, Zhang, Shuai, Zern, Mark A., Ma, Keqiang, Wang, Bailin, Ou, Yimeng, Gu, Weili, Cao, Jie, Chen, Honglin, and Duan, Yuyou

Abstract

Additional file 1. Extra materials and methods, additional figures and antibodies used in this study shown.

Published
2021
Full Text
View/download PDF

10. sj-pdf-1-sco-10.1177_2050313X211027737 – Supplemental material for Effective management of advanced colon cancer genotyping microsatellite stable/microsatellite instable-low with Kirsten rat sarcoma viral oncogene mutation using nivolumab plus ipilimumab combined with regorafenib and irinotecan: A case report

Author

Cui, Yingqiang, Ou, Yimeng, Luo, Yongping, Yu, Jiongbiao, Lin, Yiguang, and Chen, Size

Subjects
viruses, FOS: Veterinary sciences, 111199 Nutrition and Dietetics not elsewhere classified, Cardiology, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110604 Sports Medicine, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, 111702 Aged Health Care, 111403 Paediatrics, 110904 Neurology and Neuromuscular Diseases, 110203 Respiratory Diseases, 110315 Otorhinolaryngology, 70706 Veterinary Medicine, FOS: Clinical medicine, fungi, 110319 Psychiatry (incl. Psychotherapy), FOS: Sociology, FOS: Psychology, 110599 Dentistry not elsewhere classified, 110323 Surgery, 110305 Emergency Medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-sco-10.1177_2050313X211027737 for Effective management of advanced colon cancer genotyping microsatellite stable/microsatellite instable-low with Kirsten rat sarcoma viral oncogene mutation using nivolumab plus ipilimumab combined with regorafenib and irinotecan: A case report by Yingqiang Cui, Yimeng Ou, Yongping Luo, Jiongbiao Yu, Yiguang Lin and Size Chen in SAGE Open Medical Case Reports

Published
2021
Full Text
View/download PDF

11. Establishment of a 3D model of tumor-driven angiogenesis to study the effects of anti-angiogenic drugs on pericyte recruitment

Author

Qiu, Yaqi, primary, Wang, Ning, additional, Guo, Tingting, additional, Liu, Shoupei, additional, Tang, Xianglian, additional, Zhong, Zhiyong, additional, Chen, Qicong, additional, Wu, Haibin, additional, Li, Xiajing, additional, Wang, Jue, additional, Zhang, Shuai, additional, Ou, Yimeng, additional, Wang, Bailin, additional, Ma, Keqiang, additional, Gu, Weili, additional, Cao, Jie, additional, Chen, Honglin, additional, and Duan, Yuyou, additional

Published
2021
Full Text
View/download PDF

13. Characterization of genomic alterations, tumor mutational burden and PDL1 expression in 181 Chinese hepatocellular carcinomas.

Author

Ling, Qi, primary, Yang, Pingzhou, additional, Tang, Xiaofeng, additional, Hong, Defei, additional, Qu, Linlin, additional, Feng, Yujie, additional, Ou, Yimeng, additional, Li, Yong, additional, Shi, Yujun, additional, Xiao, Chunwen, additional, Li, Yanlin, additional, Wang, Kai, additional, Wang, Weifeng, additional, and Bu, Hong, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results