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Additional file 1: Supplementary figure 1. The relationship between EAPCs and ASDR in 1990 at the national level. EAPCs of death due to LCHB (A), LCHC (B), LCAL (B), and LCNA (D) had negative associations with the corresponding ASDR in 1990. The association was calculated with Pearson correlation analysis. The size of circle increases with the corresponding death number in 1990. LCHB, liver cancer due to hepatitis B; LCHC, liver cancer due to hepatitis C; LCAL, liver cancer due to alcohol consumption; LCNA, liver cancer due to non-alcoholic steatohepatitis; EAPCs, estimated annual percentage changes; ASDR, age-standardized death rate. Supplementary figure 2. The relationship between EAPCs and HDI in 2019 at the national level. EAPCs of death due to LCHB (A), LCHC (B), LCAL (B), and LCNA (D) had positive associations with HDI in 2019. The association was calculated with Pearson correlation analysis. The size of circle increases with the corresponding death numbers in 2019. LCHB, liver cancer due to hepatitis B; LCHC, liver cancer due to hepatitis C; LCAL, liver cancer due to alcohol consumption; LCNA, liver cancer due to non-alcoholic steatohepatitis; EAPCs, estimated annual percentage changes; HDI, human development index. Supplementary figure 3. The distribution of death number of LCHB in age groups, SDI areas, and geographic regions from 1990 to 2019. (A) the death number of LCHB in age groups; (B) the ASDR of LCHB in SDI areas; (C) the ASDR of LCHB in geographical regions. LCHB, liver cancer due to hepatitis B; ASDR, age-standardized death rate; SDI, sociodemographic index. Supplementary figure 4. The distribution of percentage changes in number and EAPCs of death caused by LCHB at the national level from 1990 to 2019. (A) The ASDR of LCHB in 2019; (B) The percentage changes in death number of LCHB; (C) EAPCs of death due to LCHB. Countries/territories with an extreme value were annotated. LCHB, liver cancer due to hepatitis B; ASDR, age-standardized death rate; EAPC, estimated annual percentage change. Supplementary figure 5. The distribution of death number of LCHC in age groups, SDI areas, and geographic regions from 1990 to 2019. (A) the death number of LCHC in age groups; (B) the ASDR of LCHC in SDI areas; (C) the ASDR of LCHC in geographical regions. LCHC, liver cancer due to hepatitis C; ASDR, age-standardized death rate; SDI, sociodemographic index. Supplementary figure 6. The distribution of percentage changes in number and EAPCs of death caused by LCHC at the national level from 1990 to 2019. (A) The ASDR of LCHC in 2019; (B) The percentage changes in death number of LCHC; (C) EAPCs of death due to LCHC. Countries/territories with an extreme value were annotated. LCHC, liver cancer due to hepatitis C; ASDR, age-standardized death rate; EAPC, estimated annual percentage change. Supplementary figure 7. The distribution of death number of LCAL in age groups, SDI areas, and geographic regions from 1990 to 2019. (A) the death number of LCAL in age groups; (B) the ASDR of LCAL in SDI areas; (C) the ASDR of LCAL in geographical regions. LCAL, liver cancer due to alcohol use; ASDR, age-standardized death rate; SDI, sociodemographic index. Supplementary figure 8. The distribution of percentage changes in number and EAPCs of death caused by LCAL at the national level from 1990 to 2019. (A) The ASDR of LCAL; (B) The percentage changes in number of death due to LCAL; (C) EAPCs of death due to LCAL. Countries/territories with an extreme value were annotated. LCAL, liver cancer due to alcohol use; EAPC, estimated annual percentage change. Supplementary figure 9. The distribution of death number of LCNA in age groups, SDI areas, and geographic regions from 1990 to 2019. (A) the death number of LCNA in age groups; (B) the death number of LCNA in SDI areas; (C) the death number of LCNA in geographical regions. LCNA, liver cancer due to non-alcoholic steatohepatitis; ASDR, age-standardized death rate; SDI, sociodemographic index. Supplementary figure 10. The distribution of percentage changes in number and EAPCs of death caused by LCNA at the national level from 1990 to 2019. (A) The ASDR of LCNA; (B) The percentage changes in number of death due to LCNA; (C) EAPCs of death due to LCNA. Countries/territories with an extreme value were annotated. LCNA, liver cancer due to non-alcoholic steatohepatitis; EAPC, estimated annual percentage change. Supplementary figure 11. The distribution of ASDR of LCHB, LCHC, LCAL, and LCNA due to attributable risks from 1990 to 2019. The ASDR of LCHB, LCHC, LCAL, and LCNA due to attributable risks were (A), (B), (C), and (D), respectively. LCHB, liver cancer due to hepatitis B; LCHC, liver cancer due to hepatitis C; LCAL, liver cancer due to alcohol use; LCNA, liver cancer due to non-alcoholic steatohepatitis; ASDR, age-standardized death rate. Supplementary figure 12. The overall death rate of LCHB by sex, age groups, and attributable risks. Death rate due to LCHB in both sexes, male, and female were (A), (B), and (C), respectively. The upper column in each group is data in 1990 and the lower column in 2019. LCHB, liver cancer due to hepatitis B. Supplementary figure 13. The death overall rate of caused by LCHC by sex, age groups, and attributable risks. Death rate due to LCHC in both sexes, male, and female were (A), (B), and (C), respectively. The upper column in each group is data in 1990 and the lower column in 2019. LCHC, liver cancer due to hepatitis C. Supplementary figure 14. The death overall rate of caused by LCAL by sex, age groups, and attributable risks. Death rate due to LCAL in both sexes, male, and female were (A), (B), and (C), respectively. The upper column in each group is data in 1990 and the lower column in 2019. LCAL, liver cancer due to alcohol use. Supplementary figure 15. The death overall rate of caused by LCNA by sex, age groups, and attributable risks. Death rate due to LCNA in both sexes, male, and female were (A), (B), and (C), respectively. The upper column in each group is data in 1990 and the lower column in 2019. LCNA, liver cancer due to non-alcoholic steatohepatitis.

Additional file 2: Supplementary table 1. The number and age-standardized rate of death due to liver cancer at national level and both sexes in 1990 and 2019, and EAPCs and the percentage change in number from 1990 to 2019. Supplementary table 2. The percentage change in number and the EAPCs of death attribute to liver cancer caused by specific etiologies in global, sexes, SDI areas and geographic regions from 1990 to 2019. Supplementary table 3. The percentage change in number and the EAPCs of death due to liver cancer caused by specific etiologies at national level from 1990 to 2019. Supplementary table 4. The percentage change in number and the EAPCs of death attribute to liver cancer caused by specific etiologies in global, sexes, SDI areas and geographic regions from 1990 to 2019. Supplementary table 5. The percentage change in number and the EAPCs of death due to liver cancer caused by specific etiologies at national level from 1990 to 2019.

Additional file 1: Figure S1. The distribution of number and ASR of incidence and death of neonatal preterm birth in SDI areas, and geographic regions from1990 to 2019. Figure S2. The distribution of number and ASR of incidence and death of neonatal encephalopathy due to birth asphyxia and trauma in SDI areas, and geographic regions from1990 to 2019. Figure S3. The distribution of number and ASR of incidence and death of neonatal sepsis and other neonatal infections in SDI areas, and geographic regions from1990 to 2019. Figure S4. The distribution of number and ASR of incidence and death of hemolytic disease and other neonatal jaundice in SDI areas, and geographic regions from1990 to 2019. Figure S5. The distribution of percentage changes in number of neonatal disorders incidence in specific causes at the national level. Figure S6. The distribution of EAPCs of neonatal disorders incidence in specific causes at the national level. Figure S7. The distribution of percentage changes in number of death caused by neonatal disorders in specific causes at the national level. Figure S8. The distribution of percentage changes in number of death caused by neonatal disorders in specific causes at the national level. Table S1. the age-standardized rate of incidence and death of neonatal disorders at national level in 2019, and percentage changes in number and the EAPCs from 1990 to 2019. Table S2. The percentage changes in number and the EAPCs of neonatal disorders incidence due to specific causes in global, SDI areas and geographic regions from 1990 to 2019. Table S3. the percentage changes in number and the EAPCs of incidence of neonatal disorders due to etiologies at national level from 1990 to 2019. Table S4. The percentage changes in number and the EAPCs of death caused by neonatal disorders in etiologies in global, SDI areas and geographic regions from 1990 to 2019. Table S5. the percentage changes in number and the EAPCs of death caused by neonatal disorders in etiologies at national level from 1990 to 2019.

Additional file 1: Figure S1. The number of RHD prevalence in age groups, SDI areas and geographic regions from 1990 to 2019. (A), the prevalence number in age groups; (B) the prevalence number in SDI areas; (C) the prevalence number in geographical regions. RHD: rheumatic heart disease; SDI, sociodemographic index. Figure S2. The ASR, percentage changes, and EAPCs of RHD prevalence at the national level, 1990-2019. (A), the ASR in 2019; (B), the percentage changes in number between 2000 and 2019; (C), the EAPCs in countries/territories, respectively. Countries/territories with an extreme value were annotated. RHD: rheumatic heart disease; ASR, age- standardized rate; EAPC, estimated annual percentage change. Figure S3. The death number of RHD in age groups, SDI areas, and geographic regions from 1990 to 2019. (A), (B), and (C) were the death number in age groups, SDI areas, and geographical regions, respectively. RHD: rheumatic heart disease; SDI, sociodemographic index. Figure S4. The ASR, percentage changes, and EAPCs of death caused by RHD at the national level, 1990-2019. (A), the ASR in 2019; (B), the percentage changes in number between 2000 and 2019; (C), the EAPCs in countries/territories, respectively. Countries/territories with an extreme value were annotated. RHD: rheumatic heart disease; ASR, age-standardized rate; EAPC, estimated annual percentage change. Figure S5. The number of DALYs caused by RHD in age groups, SDI areas, and geographic regions from 1990 to 2019. (A), (B), and (C) were the death number in age groups, SDI areas, and geographical regions, respectively. RHD: rheumatic heart disease; SDI, sociodemographic index. DALYs, disability-adjusted life years. Figure S6. The ASR, percentage changes, and EAPCs of DALYs caused by RHD at the national level, 1990-2019. (A), the ASR in 2019; (B), the percentage changes in number between 2000 and 2019; (C), the EAPCs in countries/territories, respectively. Countries/territories with an extreme value were annotated. RHD: rheumatic heart disease; ASR, age-standardized rate; EAPC, estimated annual percentage change; DALYs, disability-adjusted life years. Figure S7. The rate of death and DALYs caused by RHD by age and attributable risks from 1990 to 2019. (A) the attributable risks-related all age rate of death in age groups; (B) age-standardized rate of death from 1990 to 2019; (C) the attributable risks-related all age rate of DALYs in age groups; (D) age-standardized rate of DALYs from 1990 to 2019. In the (A) and (C), the upper column in each group is the data in 1990, and the lower column is in 2019. RHD: rheumatic heart disease; DALYs, disability-adjusted life years. Figure S8. The distribution of rate of death caused by RHD by sex, age and attributable risks. (A) the attributable risks-related all age rate of death in males, age groups; (B) age-standardized rate of death in males from 1990 to 2019; (C) the attributable risks-related all age rate of death in females, age groups; (D) age-standardized rate of death in females from 1990 to 2019. In the (A) and (C), the upper column in each group is the data in 1990, and the lower column is in 2019. RHD: rheumatic heart disease. Figure S9. The distribution of rate of DALYs caused by RHD by sex, age and attributable risks. (A) the attributable risks-related all age rate of DALYs in males, age groups; (B) age-standardized rate of DALYs in males from 1990 to 2019; (C) the attributable risks-related all age rate of DALYs in females, age groups; (D) age-standardized rate of DALYs in females from 1990 to 2019. In the (A) and (C), the upper column in each group is the data in 1990, and the lower column is in 2019. RHD: rheumatic heart disease; DALYs, disability-adjusted life years. Table S1. The number of RHD in 2019, and the percentage changes in number during the period 1990-2019 in age groups. Table S2. The age-standardized rate of incidence and prevalence of RHD at national level and both sexes in 2019, and percentage changes and EAPCs from 1990 to 2019. Table S3. The age-standardized rate of death and DALYs caused by RHD at national level and both sexes in 2019, and percentage changes and EAPCs from 1990 to 2019. Table S4. The age-standardized rate of death and DALYs caused by RHD at national level and both sexes in 2019, and percentage changes and EAPCs from 1990 to 2019. Table S5. The number and age-standardized rate of death and DALYs due to RHD in attributable risk factors globally, in sexes, in 2019, and percentage change in number and the EAPCs from 1990 to 2019. Table S6. The EAPCs of death and DALYs due to RHD in attributable risk factors in SDI quintiles from 1990 to 2019.