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In 2021 the International Science Programme (ISP) at Uppsala University celebrated its 60th anniversary. In spite of the Covid-19 pandemic, ISP made its best effort to honor the occasion and organised virtual workshops, meetings, and webinars during the year. This book represents the conclusive item of the jubilee year. Here we want to present the work ISP has performed since the beginning of the new millennium, narrated directly by the voices of scientists from all over the world who are or were part of the ISP family. They can now tell the significance and the impact that ISP has had on their own careers, their institutions and their countries. The book contains also contributions by the ISP staff, describing the historical evolution of ISP during the last 20 years, including for example the investment in gender equality which has raised a large interest in the supported partners. ISP has a long story, starting in 1961 as the International Seminar for Research and Education in Physics, when fellows from 14 developing countries were invited to Sweden to spend one year performing research work. Today the ISP core programme, which has evolved into three different programmes in physics, chemistry and mathematics, is devoted to assisting and strengthening research capacity building in a number of low and lower-middle income countries in Africa, Asia and Latin America. ISP supports both research groups and international scientific networks, with scientists from different countries. More recently, ISP has also been engaged as the Swedish coordinator of all Sida bilateral research programmes, as well as in other collaborations with for example Thailand International Cooperation Agency (TICA) and American Institute of Physics (AIP). The final aim of the book is to express not only the hard work performed by ISP staff and all the partners in the supported research groups and institutions, but especially the success of the efforts and the great enthusiasm that has permeated