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Wearable heart monitors are crucial for early diagnosis and treatment of heart diseases in non‐clinical settings. However, their long‐term applications require skin‐interfaced materials that are ultrasoft, breathable, antibacterial, and possess robust, enduring on‐skin adherence—features that remain elusive. Here, we have developed multifunctional porous soft composites that meet all these criteria for skin‐interfaced bimodal cardiac monitoring. The composite consists of a bilayer structure featuring phase‐separated porous elastomer and slot‐die‐coated biogel. The porous elastomer ensures ultrasoftness, breathability, ease of handling, and mechanical integrity, while the biogel enables long‐term on‐skin adherence. Additionally, we incorporated ε‐polylysine in the biogel to offer antibacterial properties. Also, the conductive biogel embedded with silver nanowires was developed for use in electrocardiogram sensors to reduce contact impedance and ensure high‐fidelity recordings. Furthermore, we assembled a bimodal wearable cardiac monitoring system that demonstrates high‐fidelity recordings of both cardiac electrical (electrocardiogram) and mechanical (seismocardiogram) signals over a 14‐day testing period. [ABSTRACT FROM AUTHOR]

Sonodynamic therapy (SDT) with non‐invasiveness and high tissue‐penetrating ability has attracted widespread interest in treating deep‐seated tumors or infections. To enhance the treatment efficacy of SDT, the development of high‐efficiency and stable sonosensitizers are still needed. Herein, a defective homojunction porphyrin‐based metal‐organic framework (MOF) with greatly enhanced sonocatalytic ability is easily prepared and used for SDT of osteomyelitis infected by methicillin‐resistant Staphylococcus aureus (MRSA). Acetic acid and benzoic acid are chosen as modulators during the hydrothermal synthesis of porphyrin‐based MOF. It is found that the crystal structure of MOF shifts from PCN‐222 to PCN‐224 as the amount of acetic acid increases. Interestingly, the defective PCN (D‐PCN) contains a two‐phase homojunction structure of PCN‐222/PCN‐224. The sonocatalytic reactive oxygen species production presents a volcano‐type trend with increased acetic acid, among which D‐PCN‐2 with more content of PCN‐224 has the best sonocatalytic antibacterial ability. The reduced band gap introduced a defect, and type‐II homojunction structures of D‐PCN‐2 improve the separation of the ultrasound‐triggered electron hole, which significantly enhances the SDT effect. Through a mixed linker approach, this work develops a new defect‐induced homojunction MOF with great performance for SDT of MRSA‐infected osteomyelitis. [ABSTRACT FROM AUTHOR]

Wound biofilm infection has an inherent resistance to antibiotics, requiring physical debridement combined with chemical reagents or antibiotics in clinical treatment, but it is invasive and may exist as incomplete debridement. So, a new type of noninvasive and efficient treatment is needed to address this problem. Here, the crystal phase engineering of TiO 2 is presented to explore the sonocatalytic properties of TiO 2 nanoparticles with different phases, and find that the anatase-brookite TiO 2  (AB) has the best antibacterial efficiency of 99.94% against S. aureus under 15 min of ultrasound (US) irradiation. The type II homojunction of AB not only enhances the adsorption and decreases the activation energy of O 2 , respectively, but also has a great interfacial charge transfer efficiency under US, which can produce more reactive oxygen species than other types of TiO 2 . The microneedles (MN) penetrate the biofilm in wound tissue and quickly disperse the loaded AB into the biofilm because the ultrasonic cavitation accelerates the dissolution of microneedles, which non-invasively and efficiently eradicates the deep-layered biofilm under US. This work explores the relationship between the phase composition of TiO 2 and sonocatalytic property for the first time, and provides a new treatment strategy for wound biofilm infection through US-assisted microneedles therapy., (© 2022 Wiley-VCH GmbH.)

Osteomyelitis is considered as the most serious bone infection, which can lead to the bone destruction or fatal sepsis. Clinical treatments through frequent antibiotics administration and surgical debridement bring inevitable side effects including drug-resistance and disfigurements. It is urgent to develop an antibiotics-free and rapid strategy to treat osteomyelitis. Herein, a bifunctional sonosensitizer that consists of porphyrin-like Zn single-atom catalysts (g-ZnN 4 ) and MoS 2 quantum dots is developed, which exhibits excellent sonodynamic antibacterial efficiency and osteogenic ability. It is found that the construction of heterogeneous interfaces of g-ZnN 4 -MoS 2 fully activates the adsorbed O 2 due to the increased interface charge transfer, enhanced spin-flip, and reduced activation energy of O 2 . The generated 1 O 2 can kill methicillin-resistant Staphylococcus aureus (MRSA) with an antibacterial efficiency of 99.58% under 20 min of ultrasound (US) irradiation. The Zn single atoms immobilized in g-ZnN 4 can be released steadily in the form of Zn 2+ for 28 days within safe concentration, realizing the great osteoinductive ability of such a sonosensitizer. For the treatment of MRSA-infected osteomyelitis, the inflammation and bone loss can be significantly suppressed through sonodynamic ion therapy. This work provides another strategy for developing high efficiency sonosensitizer through ultrasound interfacial engineering., (© 2021 The Authors. Small published by Wiley-VCH GmbH.)