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1. A two-step mechanism for TRF2-mediated chromosome-end protection

Author

Okamoto, Keiji, Bartocci, Cristina, Ouzounov, Iliana, Diedrich, Jolene K., Yates, III, John R., and Denchi, Eros Lazzerini

Subjects
Binding proteins -- Observations, DNA damage -- Research, Telomeres -- Properties, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Mammalian telomeres repress DNA-damage activation at natural chromosome ends by recruiting specific inhibitors of the DNA-damage machinery that form a protective complex termed shelterin. Within this complex, TRF2 (also known [...]

Published
2013
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