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9. Behcet's Disease: New Concepts in Cardiovascular Involvements and Future Direction for Treatment

Author

Owlia, M. B. and Mehrpoor, G.

Subjects
Article Subject
Abstract

Behcet’s disease (BD) is the only systemic vasculitis involving both arteries and vein in any sizes. It frequently encounters in rheumatology clinics. It has some major morbidities and even fatal outcomes in some cases. The aim of this paper is to analyze the main concepts on pathophysiology and treatment options in BD, focusing on cardiovascular aspects, thrombosis, and potential future treatment.

Published
2012
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11. Poster Presentations (PP01-PP67)

Author

Santos-Moreno, P., primary, Bello, J., additional, Palomino, A., additional, Villarreal, L., additional, Zambrano, D., additional, Amador, L., additional, Andrade, O., additional, Urbina, A., additional, Guzman, C., additional, Cubides, M., additional, Arbelaez, A., additional, Valle-Onate, R., additional, Galarza-Maldonado, C., additional, Brickmann, K., additional, Furst, F., additional, Kielhauser, S., additional, Hermann, J., additional, Brezinsek, H.-P., additional, Graninger, W., additional, Ziaee, V., additional, Sadghi, P., additional, Moradinejad, M.-H., additional, Yoo, D. H., additional, Woo, J.-H., additional, Kim, Y. J., additional, Kim, J. J., additional, Choi, C.-B., additional, Sung, Y.-K., additional, Kim, T.-H., additional, Jun, J.-B., additional, Bae, S.-C., additional, Park, W., additional, Joo, K., additional, Lim, M.-J., additional, Kwon, S.-R., additional, Jung., K.-H., additional, Bang, S.-Y., additional, Park, S.-R., additional, Lee, K. W., additional, Donmez, S., additional, Pamuk, O. N., additional, Pamuk, G. E., additional, Aksoy, A., additional, Almoallim, H., additional, Almasari, A., additional, Khadawardi, H., additional, Haroyan, A., additional, Petrova, M., additional, Shah, D., additional, Bhatnagar, A., additional, Wanchu, A., additional, Okada, M., additional, Ardakani, F. E., additional, Owlia, M., additional, Hesami, S., additional, Owlia, M. B., additional, Soleimani, H., additional, Saleh-Abadi, H. S., additional, Lotfi, M., additional, Dehghan, A., additional, Saberir, B., additional, Moradinejad, M. H., additional, Zamani, G., additional, Aghamohammadi, A., additional, Soheili, H., additional, shahinpour, S., additional, Abolhassani, H., additional, Hirbod, A., additional, Arandi, N., additional, Tavassoli, M., additional, Parvaneh, N., additional, Rezaei, N., additional, Rezaieyazdi, Z., additional, Hatef, M.-R., additional, Sedighi, S., additional, Ah Kim, H., additional, Chung, C. K., additional, Martinez Perez, R., additional, Leon, M., additional, Uceda, J., additional, Rodriguez Montero, S., additional, Munoz, A., additional, Velloso, M., additional, Marenco, J., additional, Tsiliakou, N., additional, Giotakos, O., additional, Koutsogeorgopoulou, L., additional, Kassimos, D., additional, Fernandes, N., additional, Silva, V., additional, Hernandez Sanchez, R., additional, Gonzalez Moreno, P., additional, Uceda Montanes, J., additional, Marenco de la Fuente, J., additional, Aytekin, E., additional, Demir, S. E., additional, Okur, S. C., additional, Caglar, N. S., additional, Tutun, S., additional, Eroglu Demir, S., additional, Rezvani, A., additional, Ozaras, N., additional, Poyraz, E., additional, Guneser, M., additional, Asik Celik, H. K., additional, Batmaz, I., additional, Sariyildiz, M., additional, Dilek, B., additional, Yildiz, I., additional, Ayyildiz, O., additional, Nas, K., additional, Cevik, R., additional, Gunay, T., additional, Garip, Y., additional, Bodur, H., additional, Baykal, T., additional, Seferoglu, B., additional, Senel, K., additional, Kara, M., additional, Tiftik, T., additional, Kaya, A., additional, Engin Tezcan, M., additional, Akif Ozturk, M., additional, Ozel, S., additional, Akinci, A., additional, Ozcakar, L., additional, Saliha Eroglu, D., additional, Ebru, A., additional, Ilhan, K., additional, Teoman, A., additional, Gulis, D., additional, Ileana, F., additional, Linda, G., additional, Cristina, P., additional, Laura, D., additional, Simona, S., additional, Simona, R., additional, Ataman, S., additional, Venkatesan, S., additional, Ng, L., additional, Carbone, C., additional, Jaeggi, E., additional, Silverman, E., additional, Kamphuis, S., additional, Mak, N., additional, Lim, L., additional, Levy, D., additional, Ciobanu, E., additional, Mazur, M., additional, Mazur-Nicorici, L., additional, Jin Park, S., additional, Cheon, E.-J., additional, Chung, C.-K., additional, Tugnet, N., additional, Dixey, J., additional, Cheng, C., additional, Schmidt, S., additional, Stoy, K., additional, Seisenbayev, A., additional, Togizbaev, G., additional, Santos-Moreno, P., additional, Gonzalez, F., additional, Villareal, L., additional, Galarza, C., additional, Nikiphorou, E., additional, MacGregor, A., additional, Morris, S., additional, James, D., additional, Young, A., additional, Alomari, M. A., additional, Shammaa, R., additional, Shqair, D. M., additional, Alawneh, K., additional, Khabour, O. F., additional, Namey, T. C., additional, Kolahi, S., additional, Haghjoo, A. G., additional, Lee, M.-J., additional, Suh, C.-H., additional, Park, Y.-W., additional, Lee, H.-S., additional, Kang, Y.-M., additional, Shim, S.-C., additional, Lee, W.-K., additional, Park, H., additional, Lee, J., additional, Wong, R.-H., additional, Huang, C.-H., additional, Cheng-Chung Wei, J., additional, Chiou, S.-P., additional, Tu, Y.-C., additional, Ok, S., additional, Kim, J.-O., additional, Lee, J.-S., additional, Sung, I.-H., additional, Kim, J.-H., additional, Lee, S.-H., additional, Choi, J., additional, Kim, S., additional, Song, R., additional, Lee, Y.-A., additional, Hong, S.-J., additional, Yang, H.-I., additional, Matsui, K., additional, Yoshida, K., additional, Oshikawa, H., additional, Kobayashi, T., additional, Nakano, H., additional, Utsunomiya, M., additional, Kimura, M., additional, Seniz, O., additional, Yoon, J., additional, Yoon, N., additional, Lee, S., additional, and Kim, Y., additional

Published
2012
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12. P113 * Clinical outcomes following double and triple valve surgery in Hong Kong

Author

Wong, H. L., primary, Ng, S. H., additional, Kwok, W. T., additional, Yeung, C. L., additional, Yu, S. Y., additional, Wan, Y. P., additional, Wan, S., additional, Underwood, M. J., additional, Bai, W. J., additional, Li, H., additional, Tang, H., additional, Wang, H., additional, Rao, L., additional, Chen, Y., additional, Peng, Y., additional, Park, Y. H., additional, Han, D. C., additional, Sohn, C. B., additional, Kim, J. S., additional, Kim, J., additional, Kim, J. H., additional, Chun, K. J., additional, Owlia, M. B., additional, Mirhoseini, S. J., additional, Naderi, N., additional, Mostafavi Pour Manshadi, S. M. Y., additional, Sayegh, S., additional, Fei, H. W., additional, Lin, C. Y., additional, He, Y. L., additional, Huang, H. L., additional, She, H. L., additional, Chan, P. H., additional, Di Mario, C., additional, Rubens, M., additional, Cheung, S. C. W., additional, Soo, W. M., additional, Ling, L. H., additional, Chan, M. Y., additional, Loh, J. P., additional, Poh, K. K., additional, Xin, W., additional, and Hong, T., additional

Published
2012
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15. Comparison Between NSAID and Intra-articular Corticosteroid Injection in Frozen Shoulder of Diabetic Patients; a Randomized Clinical Trial.

Author

Dehghan, A., Pishgooei, N., Salami, M.-A., Zarch, S. M. M., Nafisi-moghadam, R., Rahimpour, S., Soleimani, H., and Owlia, M. B.

Subjects
NONSTEROIDAL anti-inflammatory agents, CORTICOSTEROIDS, BURSITIS, INTRA-articular injections, PEOPLE with diabetes
Abstract

Introduction: Frozen shoulder or adhesive capsulitis is a relatively common encountered musculo- skeletal disease in which arouses following soft tissue involvement of glenohumeral joint and presents with pain and limitation of shoulder' active and passive motions. The incidence of frozen shoulder among diabetic patients is about 10-20 %, stiffness in such patients is more severe and should be managed actively. Local Glucocorticoid injection, NSAIDs and physiotherapy each can relief the symptoms. The aim of this study was to compare the efficacy of glenohumeral injection of Glucocorticoid with NSAIDs in frozen shoulder of diabetic patients. Method: The randomized clinical trial study conducted during Feb 2009-Aug 2010 on diabetic patients with frozen shoulder that were referred to rheumatology and endocrinology clinics, Yazd, Iran. Diagnostic criteria of capsulitis were pain of shoulder and range of motion limitation in all directions. The patients were divided into 2 groups, patients of first group received NSAID while the latter group were undergone intraarticular corticosteroid injection. After 1 week, home exercise was done for both group and evaluation of the patients after first visit was done likewise 2nd , 6th , 12th and 24th weeks. All registered data were transformed into SPSS-15 software and analyzed. Results: Totally 57 patients (19 males (33.3 %) and 38 females (66.7 %) were included in the analysis. There was no significant difference between sex (P = 0.4) and age (P = 0.19) of patients. No significant relation was detected between 2 groups after 24 weeks according to range of motion in flexion (P = 0.51), abduction (P = 0.76), external rotation (0.12) and internal rotation (P = 0.91). Also any significant difference in pain score was not detected (P = 0.91). Conclusion: Based on our study, both intraarticular corticosteroid and NSAID are effective in treatment of adhesive capsulitis and there is no significant difference between efficacies of these 2 treatment modalities in diabetic patients. [ABSTRACT FROM AUTHOR]

Published
2013
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16. Differences in clinical presentation of ankylosing spondylitis in men and women

Author

Soleymani Salehabadi, H., Kouvei, S. S., Owlia, M. B., Dehghan, A., and Masoud Mohammadi

Subjects
lcsh:R5-920, ankylosing spondylitis, clinical presentation, gender, cross-sectional studies, lcsh:Medicine (General)
Abstract

Background: Ankylosing spondylitis (AS) is an inflammatory disease that mainly affects axial skeleton of the body and ankylosing spondylitis ligaments around the spine at the junction of the spine are inflamed, because the disease is progressive and can lead to significantly cause of disability and the studies could provide a mechanism for the early detection of the disease or help determine when to start treatment, the difference in clinical presentations of AS in men and women is indicative of potential effect of gender on severity of the disease. This study was conducted with the aim to investigate the effect of gender on severity of AS. Methods: In a cross-sectional study, one hundred and fifteen patients with ankylosing spondylitis who referred to Yazd Rheumatology Clinic between 2001 and 2013 were evaluated. Sampling was performed using non-random convenient method. The most important variables studied included demographic data, clinical presentation, radiographic stage of sacroiliac involvement, and laboratory data extracted from patients’ files and recorded in questionnaires. Results: Both groups according to age at diagnosis, presence of enteritis, peripheral joint involvement and laboratory data such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and hemoglobin were matched. Inflammatory neck pain was more prevalent in men than in women (77.2% against 51.8%; P< 0.05). Sacroiliac radiographic study revealed stage 1 involvement in 11.3% of men and 37% of women (P= 0.009), and stage 4 in 27.2% of men and 3.7% of women (P< 0.001), with a significant difference. Conclusion: According to the results of the study, the time between age of onset and age at diagnosis, inflammatory pain in the neck and advanced stage in men than in women was higher. Although these findings suggest that gender may have an impact on the pattern and severity of AS but the time delay in diagnosis as a disease affecting the intensity and pattern should not be overlooked.

18. Role of vitamin D in flare ups of rheumatoid arthritis.

Author

Dehghan A, Rahimpour S, Soleymani-Salehabadi H, and Owlia MB

Subjects
Arthritis, Rheumatoid diagnosis, Biomarkers blood, Female, Humans, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome, Vitamin D Deficiency diagnosis, Arthritis, Rheumatoid blood, Arthritis, Rheumatoid drug therapy, Vitamin D blood, Vitamin D therapeutic use, Vitamin D Deficiency blood, Vitamin D Deficiency prevention & control
Abstract

Introduction: Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases worldwide. Some researchers have suggested that the serum vitamin D (Vit D) level may relate to disease activity. The current study was designed to identify the correlation between vitamin D prescription and prevention of relapses in rheumatoid arthritis., Patients and Method: A double blinded, randomized controlled trial study was performed using 80 RA patients. RA was controlled and patients were in remission during the past 2 months. Serum level of Vit D in the studied patients was below 30 ng/dl. Patients were randomly allocated to receive Vit D or placebo. In the 6-month follow-up period, the Disease Activity Score 28 (DAS28) was used in case of relapses as an index of RA activity to compare the two groups., Results: The flare rate was not different between two groups (p > 0.05). The odds ratio of the rate of decline in patients of the trial group compared with the control group was 1.17 (not significant; p > 0.05). The mean DAS28 between the two patient groups was not significant (p > 0.05)., Conclusion: A low Vit D level was not identified to be a risk factor for RA severity or flare ups; however, although not statistically significant, Vit D treatment might be clinically effective. Further studies are needed with more emphasis on the issue of cost effectiveness and clinical importance to provide more information.

Published
2014
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19. Cryoglobulinaemia in hepatitis C-positive patients in Iran.

Author

Owlia MB, Sami R, Akhondi M, and Salimzadeh A

Subjects
Adolescent, Adult, Age Distribution, Cohort Studies, Comorbidity, Female, Humans, Iran epidemiology, Liver Function Tests, Male, Middle Aged, Prevalence, Probability, Severity of Illness Index, Sex Distribution, Cryoglobulinemia diagnosis, Cryoglobulinemia epidemiology, Hepacivirus isolation & purification, Hepatitis C diagnosis, Hepatitis C epidemiology
Abstract

Introduction: Cryoglobulins are found in a wide spectrum of disorders but are often transient and without clinical implications. The so-called essential mixed cryoglobulinaemia shows a striking association with hepatitis C virus (HCV) infection (greater than 90 percent). Type II cryoglobulinaemia is the major extrahepatic manifestation of HCV infection. This study aims to investigate the frequency of cryoglobulinaemia in HCV-positive patients in central Iran., Methods: 50 HCV-positive patients referred to the Shaheed Sadoughi Hospital in Yazd, Iran from May 2004 to December 2005, were included in the study. Their sera were assessed for cryoglobulins. The sera were separated by centrifugation at 37 degrees Celsius and placed in a four degrees Celsius refrigerator in two tubes, one simple and the other, a Wintrobe tube, to see if precipitation occurs during a 48-hour up to a seven-day period., Results: In this study, 50 HCV positive patients were evaluated. Only two patients were female. Mean age was 32 years (ranging from 17 to 52 years). In eight patients, the cryoglobulin test was positive. In seven patients, the test became positive less than 72 hours after sampling. Only one patient who was positive for cryoglobulinaemia, had clinical manifestation of frank vasculitis., Conclusion: The prevalence of cryoglobulinaemia in Iran may be lower than other areas, and it may be due to a higher prevalence of cryoglobulinaemia in females and lower prevalence of cryoglobulinaemia in HCV genotype-1a. Most of the cases in our study were male and the more prevalent genotype in Iran is genotype-1a.

Published
2007

20. Comparison of two doses of corticosteroid in epidural steroid injection for lumbar radicular pain.

Author

Owlia MB, Salimzadeh A, Alishiri G, and Haghighi A

Subjects
Adult, Female, Humans, Injections, Epidural, Male, Methylprednisolone administration & dosage, Methylprednisolone Acetate, Pain Measurement, Anti-Inflammatory Agents administration & dosage, Glucocorticoids administration & dosage, Methylprednisolone analogs & derivatives, Radiculopathy drug therapy
Abstract

Introduction: Low back pain and lumbar radicular pain are the leading causes of job loss worldwide. Therapeutic approaches to lumbar radicular pain, including sciatica and spinal canal stenosis, are diverse. Many clinicians use 80 mg long-acting glucocorticoids in epidural steroid injections (ESI). The aim of this study is to compare the clinical response of 80 mg versus 40 mg methylprednisolone in ESI., Methods: 84 patients with newly exacerbated lumbar radicular pain were randomly al located into two groups. 43 patients under went ESI with 80 mg Depo-Medrol and 41 age- and sex-matched cases received 40 mg Depo-Medrol as the comparison group. The pain in the second week, and every month thereafter was assessed using a visual analogue scale (VAS)., Results: Remarkable improvement in one month VAS occurred in 64 cases (75 percent) from both groups. VAS values between 80 mg and 40 mg groups were comparable in the two-week (p-value is 0.827) and three-month (p-value is greater than 0.746) post-injection periods. Slightly better results were shown in patients in the 40 mg group after one month., Conclusion: In the case of lumbar radicular pain, ESI with low dose (40 mg) methylprednisolone is as effective as high dose (80 mg) with comparable results and less adverse profile.

Published
2007

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