27 results on '"Oyoo, O."'
Search Results
2. Traditional cardiovascular risk factors in patients with rheumatoid arthritis at Kenyatta National Hospital and compare with healthy controls: 703147
- Author
-
OYOO, O
- Published
- 2012
3. Smoking cessation advice by rheumatologists: results of an international survey
- Author
-
Naranjo, A, Khan, N. A., Cutolo, M., Lee, S., Lazovskis, J, Laas, K., Pandya, S, Sokka, T., Fabiana, M. S., Da Silveira, I. G., Laurindo, I. M., Horslev-Petersen, K. l, Hetland, M. L, Müller, R., Schett, G., Wassenberg, S., Alten, R., Drosos, A. A, Rojkovich, B, Géher, P, Aggarwal, Tanya, Cazzato, M, Fukuda, W., Nakajima, A., Yamanaka, H., Shono, E., Oyoo, O., Rexhepi, B., Rexhepi, S., Andersone, D., Baranauskaite, A., Bonte-Mineur, F., Haugeberg, G., Majdan, M., Targonska-Stepniak, B., Codrina, A., Ionescu, R., Choe, J. -Y., Lee, E. B., Gogus, F., Inanc, N., Direskeneli, H., Yazici, Y., and Bergman, M.
- Subjects
rheumatoid arthritis ,Questionnaires ,medicine.medical_specialty ,medicine.medical_treatment ,Physician's Practice Patterns ,medical advice ,Rheumatology ,Medical advice ,Physicians ,Surveys and Questionnaires ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,tobacco smoking ,Practice Patterns, Physicians' ,business.industry ,International survey ,Health Care Surveys ,Smoking Cessation ,medicine.disease ,Smoking cessation advice ,Homogeneous ,Family medicine ,Rheumatoid arthritis ,Physical therapy ,Smoking cessation ,business ,Patient education - Abstract
Objective The aim of this study was to understand practices regarding smoking cessation among rheumatologists for patients with inflammatory rheumatic diseases. Methods A survey was sent to the rheumatologists participating in the multinational Quantitative Standard Monitoring of Patients with Rheumatoid Arthritis (QUEST-RA) group. The survey inquired about the clinical practice characteristics and practices regarding smoking cessation (proportion of smokers with inflammatory rheumatic diseases given smoking cessation advice, specific protocols and written advice material, availability of dedicated smoking cessation clinic). Results Rheumatologists from 44 departments in 25 countries (16 European) completed the survey. The survey involved 395 rheumatologists, of whom 25 (6.3%) were smokers, and 199 nurses for patient education, of whom 44 (22.1%) were smokers. Eight departments (18.1 %) had a specific protocol for smoking cessation; 255 (64.5%) rheumatologists reported giving smoking cessation advice to all or almost all smokers with inflammatory diseases. In a regression model, early arthritis clinics (P = 0.01) and high gross domestic product countries (P = 0.001) were both independently associated with advice by the rheumatologist. Nurse gives advice to most patients in 11 of the 36 (30.5%) departments with nurses for patient education. Conclusion Advice for smoking cessation within rheumatology departments is not homogeneous. In half of the departments, most doctors give advice to quit smoking to all or almost all patients with inflammatory diseases. However, only one in five departments have a specific protocol for smoking cessation. Our data highlight the need to improve awareness of the importance of and better practice implementation of smoking cessation advice for inflammatory rheumatic disease patients.
- Published
- 2014
- Full Text
- View/download PDF
4. Patient's global assessment of disease activity and patient's assessment of general health for rheumatoid arthritis activity assessment: are they equivalent?
- Author
-
Khan, Na, Spencer, Hj, Abda, Ea, Alten, R, Pohl, C, Ancuta, C, Cazzato, M, Géher, P, Gossec, L, Henrohn, D, Hetland, Ml, Inanc, N, Jacobs, Jw, Kerzberg, E, Majdan, M, Oyoo, O, Peredo Wende RA, Selim, Zi, Skopouli, Fn, Sulli, Alberto, Hørslev Petersen, K, Taylor, Pc, Sokka, T, and on behalf of QUEST RA group
- Subjects
Adult ,Male ,medicine.medical_specialty ,Databases, Factual ,Health Status ,Concordance ,Immunology ,Activity assessment ,Arthritis ,Severity of Illness Index ,Article ,General Biochemistry, Genetics and Molecular Biology ,Arthritis, Rheumatoid ,Disease activity ,Rheumatology ,Surveys and Questionnaires ,Internal medicine ,Severity of illness ,medicine ,Humans ,Immunology and Allergy ,Fatigue ,Aged ,business.industry ,Middle Aged ,medicine.disease ,Arthralgia ,Connective tissue disease ,Rheumatoid arthritis ,Physical therapy ,Female ,Self Report ,General health ,business - Abstract
OBJECTIVES: To assess (A) determinants of patient's global assessment of disease activity (PTGL) and patient's assessment of general health (GH) scores of rheumatoid arthritis (RA) patients; (B) whether they are equivalent as individual variables; and (C) whether they may be used interchangeably in calculating common RA activity assessment composite indices. METHODS: Data of 7023 patients from 30 countries in the Quantitative Standard Monitoring of Patients with RA (QUEST-RA) was analysed. PTGL and GH determinants were assessed by mixed-effects analyses of covariance models. PTGL and GH equivalence was determined by Bland-Altman 95% limits of agreement (BALOA) and Lin's coefficient of concordance (LCC). Concordance between PTGL and GH based Disease Activity Score 28 (DAS28), Clinical Disease Activity Index (CDAI) and Routine Assessment of Patient Index Data 3 (RAPID3) indices were calculated using LCC, and the level of agreement in classifying RA activity in four states (remission, low, moderate, high) using κ statistics. RESULTS: Significant differences in relative and absolute contribution of RA and non-RA related variables in PTGL and GH ratings were noted. LCC of 0.64 and BALOA of -4.41 to 4.54 showed that PTGL and GH are not equivalent. There was excellent concordance (LCC 0.95-0.99) for PTGL and GH based DAS28, CDAI and RAPID3 indices, and >80% absolute agreement (κ statistics 0.75-0.84) in RA activity state classification for all three indices. CONCLUSIONS: PTGL and GH ratings differ in their determinants. Although they are individually not equivalent, they may be used interchangeably for calculating composite indices for RA activity assessment.
- Published
- 2012
- Full Text
- View/download PDF
5. Assessment of Anti-Fungal Activity of Annona senegalensis Plant Parts on Malassezia globosa
- Author
-
Anthony, Ochieng O, primary, Said, Omar H, additional, Hamisi, Ibrahim, additional, Mataka, Mataka A, additional, Odalo, Ochieng J, additional, Mohamed, Pakia, additional, and Titus, Oyoo O, additional
- Published
- 2017
- Full Text
- View/download PDF
6. Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA study
- Author
-
Sokka, T, Kautiainen, H, Pincus, T, Verstappen, Sm, Aggarwal, A, Alten, R, Andersone, D, Badsha, H, Baecklund, E, Belmonte, M, CRAIG MÜLLER, J, DA MOTA LM, Dimic, A, Fathi, Na, Ferraccioli, G, Fukuda, W, Géher, P, Gogus, F, HAJJAJ HASSOUNI, N, Hamoud, H, Haugeberg, G, Henrohn, D, HORSLEV PETERSEN, K, Ionescu, R, Karateew, D, Kuuse, R, Laurindo, Im, Lazovskis, J, Luukkainen, R, Mofti, A, Murphy, E, Nakajima, A, Oyoo, O, Pandya, Sc, Pohl, C, Predeteanu, D, Rexhepi, M, Rexhepi, S, Sharma, B, Shono, E, Sibilia, J, Sierakowski, S, Skopouli, Fn, Stropuviene, S, Toloza, S, Valter, I, Woolf, A, Yamanaka, H, and Bombardieri, Stefano
- Published
- 2010
7. The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. : Results from 34 countries participating in the Quest-RA programme
- Author
-
Gron, K. L., Ornbjerg, L. M., Hetland, M. L., Aslam, F., Khan, N. A., Jacobs, J. W. G., Henrohn, Dan, Rasker, J. J., Kauppi, M. J., Lang, H. -C, Mota, L. M. H., Aggarwal, A., Yamanaka, H., Badsha, H., Gossec, L., Cutolo, M., Ferraccioli, G., Gremese, E., Lee, E. Bong, Inanc, N., Direskeneli, H., Taylor, P., Huisman, M., Alten, R., Pohl, C., Oyoo, O., Stropuviene, S., Drosos, A. A., Kerzberg, E., Ancuta, C., Mofti, A., Bergman, M., Detert, J., Selim, Z. I., Abda, E. A., Rexhepi, B., Sokka, T., Gron, K. L., Ornbjerg, L. M., Hetland, M. L., Aslam, F., Khan, N. A., Jacobs, J. W. G., Henrohn, Dan, Rasker, J. J., Kauppi, M. J., Lang, H. -C, Mota, L. M. H., Aggarwal, A., Yamanaka, H., Badsha, H., Gossec, L., Cutolo, M., Ferraccioli, G., Gremese, E., Lee, E. Bong, Inanc, N., Direskeneli, H., Taylor, P., Huisman, M., Alten, R., Pohl, C., Oyoo, O., Stropuviene, S., Drosos, A. A., Kerzberg, E., Ancuta, C., Mofti, A., Bergman, M., Detert, J., Selim, Z. I., Abda, E. A., Rexhepi, B., and Sokka, T.
- Abstract
Objective The aim is to assess the prevalence of comorbidities and to further analyse to which degree fatigue can be explained by comorbidity burden, disease activity, disability and gross domestic product (GDP) in patients with rheumatoid arthritis (RA). Methods Nine thousands eight hundred seventy-four patients from 34 countries, 16 with high GDP (>24.000 US dollars [USD] per capita) and 18 low-GDP countries (<24.000 USD) participated in the Quantitative Standard monitoring of Patients with RA (QUEST-RA) study. The prevalence of 31 comorbid conditions, fatigue (0-10 cm visual analogue scale [VAS] [10 worst]), disease activity in 28 joints (DAS28), and physical disability (Health Assessment Questionnaire score MAW) were assessed. Univariate and multivariate linear regression analyses were performed to assess the association between fatigue and comorbidities, disease activity, disability and GDP. Results Overall, patients reported a median of 2 comorbid conditions of which hypertension (31.5%), osteoporosis (17.6%), osteoarthritis (15.5%) and hyperlipidaemia (14.2%) were the most prevalent. The majority of comorbidities were more common in high-GDP countries. The median fatigue score was 4.4 (4.8 in low-GDP countries and 3.8 in high-GDP countries, p<0.001). In low-GDP countries 25.4% of the patients had a high level of fatigue (>6.6) compared with 23.0% in high-GDP countries (p<0.001). In univariate analysis, fatigue increased with increasing number of comorbidities, disease activity and disability in both high- and low-GDP countries. In multivariate analysis of all countries, these 3 variables explained 29.4% of the variability, whereas GDP was not significant. Conclusion Fatigue is a widespread problem associated with high comorbidity burden, disease activity and disability regardless of GDP.
- Published
- 2014
8. The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program
- Author
-
Grøn, Kl, Ornbjerg, Lm, Hetland, Ml, Aslam, F, Khan, Na, Jacobs, Jwg, Henrohn, D, Rasker, Jj, Kauppi, Mj, Lang, H, Mota, Lmh, Aggarwal, A, Yamanaka, H, Badsha, H, Gossec, L, Cutolo, M, Ferraccioli, Gianfranco, Gremese, Elisa, Bong Lee, E, Inanc, N, Direskeneli, H, Taylor, P, Huisman, M, Alten, R, Pohl, C, Oyoo, O, Stropuviene, S, Drosos, Aa, Kerzberg, E, Ancuta, C, Mofti, A, Bergman, M, Detert, J, Selim, Zi, Abda, Ea, Rexhepi, B, Sokka, T., Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428), Gremese, Elisa (ORCID:0000-0002-2248-1058), Grøn, Kl, Ornbjerg, Lm, Hetland, Ml, Aslam, F, Khan, Na, Jacobs, Jwg, Henrohn, D, Rasker, Jj, Kauppi, Mj, Lang, H, Mota, Lmh, Aggarwal, A, Yamanaka, H, Badsha, H, Gossec, L, Cutolo, M, Ferraccioli, Gianfranco, Gremese, Elisa, Bong Lee, E, Inanc, N, Direskeneli, H, Taylor, P, Huisman, M, Alten, R, Pohl, C, Oyoo, O, Stropuviene, S, Drosos, Aa, Kerzberg, E, Ancuta, C, Mofti, A, Bergman, M, Detert, J, Selim, Zi, Abda, Ea, Rexhepi, B, Sokka, T., Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428), and Gremese, Elisa (ORCID:0000-0002-2248-1058)
- Abstract
The aim is to assess the prevalence of comorbidities and to further analyse to which degree fatigue can be explained by comorbidity burden, disease activity, disability and gross domestic product (GDP) in patients with rheumatoid arthritis (RA).
- Published
- 2014
9. Patient's global assessment of disease activity and patient's assessment of general health for rheumatoid arthritis activity assessment : Are they equivalent?
- Author
-
Khan, N. A., Spencer, H. J., Abda, E. A., Alten, R., Pohl, C., Ancuta, C., Cazzato, M., Gher, P. I., Gossec, L., Henrohn, Dan, Hetland, M. L., Inanc, N., Jacobs, J. W. G., Kerzberg, E., Majdan, M., Oyoo, O., Peredo-Wende, R. A., Selim, Z. I., Skopouli, F. N., Sulli, A., Hrslev-Petersen, K., Taylor, P. C., Sokka, T., Khan, N. A., Spencer, H. J., Abda, E. A., Alten, R., Pohl, C., Ancuta, C., Cazzato, M., Gher, P. I., Gossec, L., Henrohn, Dan, Hetland, M. L., Inanc, N., Jacobs, J. W. G., Kerzberg, E., Majdan, M., Oyoo, O., Peredo-Wende, R. A., Selim, Z. I., Skopouli, F. N., Sulli, A., Hrslev-Petersen, K., Taylor, P. C., and Sokka, T.
- Abstract
Objectives: To assess (A) determinants of patient's global assessment of disease activity (PTGL) and patient's assessment of general health (GH) scores of rheumatoid arthritis (RA) patients; (B) whether they are equivalent as individual variables; and (C) whether they may be used interchangeably in calculating common RA activity assessment composite indices. Methods: Data of 7023 patients from 30 countries in the Quantitative Standard Monitoring of Patients with RA (QUEST-RA) was analysed. PTGL and GH determinants were assessed by mixed-effects analyses of covariance models. PTGL and GH equivalence was determined by Bland-Altman 95% limits of agreement (BALOA) and Lin's coefficient of concordance (LCC). Concordance between PTGL and GH based Disease Activity Score 28(DAS28), Clinical Disease Activity Index (CDAI) and Routine Assessment of Patient Index Data 3 (RAPID3) indices were calculated using LCC, and the level of agreement in classifying RA activity in four states (remission, low, moderate, high) using κ statistics. Results: Significant differences in relative and absolute contribution of RA and non-RA related variables in PTGL and GH ratings were noted. LCC of 0.64 and BALOA of -4.41 to 4.54 showed that PTGL and GH are not equivalent. There was excellent concordance (LCC 0.95-0.99) for PTGL and GH based DAS28, CDAI and RAPID3 indices, and >80% absolute agreement (κ statistics 0.75-0.84) in RA activity state classification for all three indices. Conclusions: PTGL and GH ratings differ in their determinants. Although they are individually not equivalent, they may be used interchangeably for calculating composite indices for RA activity assessment.
- Published
- 2012
- Full Text
- View/download PDF
10. Smokers and non-smokers with rheumatoid arthritis have similar clinical status : data from the multinational QUEST-RA database
- Author
-
Naranjo, A., Toloza, S., Guimaraes da Silveira, I., Lazovskis, J., Hetland, M. L., Hamoud, H., Peets, T., Makinen, H., Gossec, L., Herborn, G., Skopouli, F. N., Rojkovich, B., Aggarwal, A., Minnock, P., Cazzato, M., Yamanaka, H., Oyoo, O., Rexhepi, S., Andersone, D., Baranauskaite, A., Hajjaj-Hassouni, N., Jacobs, J. W. G., Haugeberg, G., Sierakowski, S., Ionescu, R., Karateew, D., Dimic, A., Henrohn, Dan, Gogus, F., Badsha, H., Choy, E., Bergman, M., Sokka, T., Naranjo, A., Toloza, S., Guimaraes da Silveira, I., Lazovskis, J., Hetland, M. L., Hamoud, H., Peets, T., Makinen, H., Gossec, L., Herborn, G., Skopouli, F. N., Rojkovich, B., Aggarwal, A., Minnock, P., Cazzato, M., Yamanaka, H., Oyoo, O., Rexhepi, S., Andersone, D., Baranauskaite, A., Hajjaj-Hassouni, N., Jacobs, J. W. G., Haugeberg, G., Sierakowski, S., Ionescu, R., Karateew, D., Dimic, A., Henrohn, Dan, Gogus, F., Badsha, H., Choy, E., Bergman, M., and Sokka, T.
- Abstract
Objectives To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RE), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as "never smoked", "currently smoking" and "former smokers". Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307 patients with smoking data available, status as "never smoked," "current smoker" and "former smoker" were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32; 1.17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41; 1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, hut values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).
- Published
- 2010
11. Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database
- Author
-
Naranjo, A, Toloza, S, Guimaraes da Silveira, I, Lazovskis, J, Hetland, M L, Hamoud, H, Peets, T, Mäkinen, H, Gossec, L, Herborn, G, Skopouli, F N, Rojkovich, B, Aggarwal, A, Minnock, P, Cazzato, M, Yamanaka, H, Oyoo, O, Rexhepi, S, Andersone, D, Baranauskaite, A, Hajjaj-Hassouni, N, Jacobs, J W G, Haugeberg, G, Sierakowski, S, Ionescu, R, Karateew, D, Dimic, A, Henrohn, D, Gogus, F, Badsha, H, Choy, E, Bergman, Ingrid-Maria, Sokka, T, Naranjo, A, Toloza, S, Guimaraes da Silveira, I, Lazovskis, J, Hetland, M L, Hamoud, H, Peets, T, Mäkinen, H, Gossec, L, Herborn, G, Skopouli, F N, Rojkovich, B, Aggarwal, A, Minnock, P, Cazzato, M, Yamanaka, H, Oyoo, O, Rexhepi, S, Andersone, D, Baranauskaite, A, Hajjaj-Hassouni, N, Jacobs, J W G, Haugeberg, G, Sierakowski, S, Ionescu, R, Karateew, D, Dimic, A, Henrohn, D, Gogus, F, Badsha, H, Choy, E, Bergman, Ingrid-Maria, and Sokka, T
- Abstract
To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status.
- Published
- 2010
12. Stepping into the state of rheumatology in East Africa
- Author
-
Oyoo, O., primary, Moots, R. J., additional, and Ganda, B., additional
- Published
- 2012
- Full Text
- View/download PDF
13. Smokers and non-smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database
- Author
-
Naranjo A, Toloza S, Guimaraes da Silveira I, Lazovskis J, Ml, Hetland, Hesham hamoud, Peets T, Mäkinen H, Gossec L, Herborn G, Fn, Skopouli, Rojkovich B, Aggarwal A, Minnock P, Cazzato M, Yamanaka H, Oyoo O, Rexhepi S, Andersone D, Baranauskaite A, Hajjaj-Hassouni N, Jw, Jacobs, Haugeberg G, Sierakowski S, Ionescu R, Karateew D, Dimic A, Henrohn D, Gogus F, Badsha H, Choy E, Bergman M, and Sokka T
- Subjects
Arthritis, Rheumatoid ,Male ,Disability Evaluation ,Cross-Sectional Studies ,genetic structures ,Databases as Topic ,International Cooperation ,Multivariate Analysis ,Smoking ,Humans ,Female ,Middle Aged ,Severity of Illness Index - Abstract
To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status.The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as 'never smoked', 'currently smoking' and 'former smokers'. Patient groups with different smoking status were compared for demographic and RA measures.Among the 7,307 patients with smoking data available, status as 'never smoked,' 'current smoker' and 'former smoker' were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1.17-1.48, p0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41;1.24-1.59, p0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category).RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).
14. The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA programme
- Author
-
Grøn, K. L., Ørnbjerg, L. M., Hetland, M. L., Aslam, F., Khan, N. A., Jacobs, J. W. G., Henrohn, D., Rasker, J. J., Kauppi, M., Lang, H. -C, Mota, L. M. H., Aggarwal, A., Yamanaka, H., Badsha, H., Gossec, L., Cutolo, M., Gianfranco Ferraccioli, Gremese, E., Lee, E. B., Inanc, N., Direskeneli, H., Taylor, P., Huisman, A. M., Alten, R., Pohl, C., Oyoo, O., Stropuviene, S., Drosos, A. A., Kerzberg, E., Ancuta, C., Mofti, A., Bergman, M., Detert, J., Selim, Z. I., Abda, E. A., Rexhepi, B., and Sokka, T.
- Subjects
Questionnaires ,Male ,Chi-Square Distribution ,Settore MED/16 - REUMATOLOGIA ,Arthritis ,Gross Domestic Product ,Rheumatoid Arthritis ,Comorbidity ,Middle Aged ,Severity of Illness Index ,Arthritis, Rheumatoid ,Disability Evaluation ,Cost of Illness ,Socioeconomic Factors ,Predictive Value of Tests ,Risk Factors ,Rheumatoid ,Surveys and Questionnaires ,Multivariate Analysis ,Linear Models ,Prevalence ,Humans ,Female ,Fatigue - Abstract
OBJECTIVES: The aim is to assess the prevalence of comorbidities and to further analyse to which degree fatigue can be explained by comorbidity burden, disease activity, disability and gross domestic product (GDP) in patients with rheumatoid arthritis (RA). METHODS: Nine thousands eight hundred seventy-four patients from 34 countries, 16 with high GDP (>24.000 US dollars [USD] per capita) and 18 low-GDP countries (6.6) compared with 23.0% in high-GDP countries (p
15. Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study
- Author
-
Jawaheer, D., Olsen, J., Lahiff, M., Forsberg, S., Lähteenmäki, J., Da Silveira, I. G., Rocha, F. A., Laurindo, I. M. M., Da Mota, L. M. H., Drosos, A. A., Murphy, E., Sheehy, C., Quirke, E., Cutolo, M., Rexhepi, S., Dadoniene, J., Verstappen, S. M. M., Sokka, T., Toloza, S., Aguero, S., Barrera, S. O., Retamozo, S., Alba, P., Lascano, C., Babini, A., Albiero, E., Pinheiro, G. R. C., Lazovskis, J., Hetland, M. L., Ørnbjerg, L., Hørslev-Petersen, K., Hansen, T. M., Knudsen, L. S., Hamoud, H., Sobhy, M., Fahmy, A., Magdy, M., Aly, H., Saeid, H., Nagm, A., Fathi, N. A., Abda, E., Ebraheam, Z., Müller, R., Kuuse, R., Tammaru, M., Kallikorm, R., Peets, T., Otsa, K., Laas, K., Valter, I., Mäkinen, H., Immonen, K., Luukkainen, R., Gossec, L., Dougados, M., Maillefert, J. F., Combe, B., Sibilia, J., Exarchou, S., Moutsopoulos, H. M., Tsirogianni, A., Skopouli, F. N., Mavrommati, M., Herborn, G., Rau, R., Alten, R., Pohl, C., Burmester, G. R., Marsmann, B., Géher, P., Rojkovich, B., Bresnihan, B., Minnock, P., Devlin, J., Alraqi, S., Aggarwal, A., Pandya, S., Sharma, B., Cazzato, M., Bombardieri, S., Ferraccioli, G., Morelli, A., Salaffi, F., Stancati, A., Yamanaka, H., Nakajima, A., Fukuda, W., Shono, E., Oyoo, O., Rexhepi, M., Andersone, D., Stropuviene, S., Baranauskaite, A., Najia Hajjaj-Hassouni, Benbouazza, K., Allali, F., Bahiri, R., Amine, B., Jacobs, J. W. G., Huisman, M., Hoekstra, M., Haugeberg, G., Gjelberg, H., Sierakowski, S., Majdan, M., Romanowski, W., Tlustochowicz, W., Kapolka, D., Sadkiewicz, S., Zarowny-Wierzbinska, D., Ionescu, R., Predeteanu, D., Karateev, D., Luchikhina, E., Chichasova, N., Badokin, V., Skakic, V., Dimic, A., Nedovic, J., Stankovic, A., Naranjo, A., Rodríguez-Lozano, C., Calvo-Alen, J., Belmonte, M., Baecklund, E., Henrohn, D., Oding, R., Liveborn, M., Holmqvist, A. -C, Gogus, F., Tunc, R., Celic, S., Badsha, H., Mofti, A., Taylor, P., Mcclinton, C., Woolf, A., Chorghade, G., Choy, E., Kelly, S., Pincus, T., Yazici, Y., Bergman, M., Craig-Muller, J., Kautiainen, H., Swearingen, C., University of California Los Angeles, University of California Berkeley, North Karelia Central Hospital, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Universidade Federal do Ceará, Universidade Estadual Paulista (UNESP), Hospital Universitário de Brasília, University of Ioannina Ioannina, Waterford Regional Hospital, Connolly Hospital, University of Genova, Rheumatology Department, Vilnius University, University Medical Centre Utrecht, Jyväskylä Central Hospital, Medcare Oy, Hospital Oakland Research Institute, Hospital San Juan Bautista, Hospital of Cordoba, Universidade do Estado do Rio de Janeiro (UERJ), Riverside Professional Centre, Copenhagen University Hospital at Hvidovre, King Christian the Xth Hospital, Copenhagen University Hospital at Herlev, Al-Azhar University, Assiut University Hospital, Abo Sohage University Hospital, Tartu University Hospital, East-Tallinn Central Hospital, Centre for Clinical and Basic Research, Satakunta Central Hospital, Hôpital Cochin, INSERM U887, Hôpital Lapeyronie, Hôpital Hautepierre, National University of Athens, Euroclinic Hospital, Evangelisches Fachkrankenhaus, Schlosspark-Klinik, University Medicine Berlin, Semmelweis University of Medical Sciences, Polyclinic of the Hospitaller Brothers of St. John of God in Budapest, St. Vincent University Hospital, Our Lady's Hospice, Vedanta Institiute of Medical Sciences, Jaipur Hospital, Santa Chiara Hospital, Catholic University of Sacred Heart, University of Ancona, Tokyo Women's Medical University, Kyoto First Red Cross Hospital, Shono Rheumatism Clinic, Kenyatta Hospital, Pauls Stradina Clinical University Hospital, Kaunas University Hospital, El Ayachi Hospital Mohamed Vth Souissi University, Sint Franciscus Gasthuis Hospital, Medisch Spectrum Twente, Sørlandet Hospital, Medical University in Bialystok, Medical University of Lublin, Poznan Rheumatology Centre in Srem, Military Institute of Medicine, Silesian Hospital for Rheumatology and Rehabilitation in Ustron Slaski, Szpital Wojewodzki im. Jana Biziela, Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko, Spitalul Clinic Sf Maria, Institute of Rheumatology of Russian Academy of Medical Sciences, Moscow Medical Academy, Russian Medical Academy of Postgraduate Education, Rheumatology Institut, Hospital de Gran Canaria Dr. Negrin, Hospital Sierrallana Ganzo, Hospital General de Castellón, Uppsala University Hospital, Centrallasarettet, Hudiksvall Medical Clinic, Gazi University Medical Faculty, Meram Medical Faculty, Cerrahpasa Medic Faculty, Dubai Bone and Joint Centre, American Hospital Dubai, Charing Cross Hospital, Royal Cornwall Hospital, Kings College Hospital, Vanderbilt University, NYU Hospital for Joint Diseases, Taylor Hospital, Centra Care Clinic, University of Arkansas for Medical Sciences, and New York University Hospital for Joint Diseases
- Subjects
Bmi ,Gender ,Disease activity ,Rheumatoid arthritis - Abstract
Made available in DSpace on 2022-04-28T18:56:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-01 Objective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men. © Copyright Clinical and Experimental Rheumatology 2010. University of California Los Angeles, Los Angeles, CA University of California Berkeley, Berkeley, CA North Karelia Central Hospital, Joensuu Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre Universidade Federal do Ceará, Fortaleza Universidade Estadual de São Paulo, São Paulo Hospital Universitário de Brasília, Brasilia University of Ioannina Ioannina Waterford Regional Hospital, Waterford Connolly Hospital, Dublin University of Genova, Genova Rheumatology Department, Pristine Institute of Experimental and Clinical Medicine Vilnius University, Vilnius University Medical Centre Utrecht, Utrecht Jyväskylä Central Hospital, Jyväskylä Medcare Oy, Äänekoski Hospital Oakland Research Institute, Oakland, CA Hospital San Juan Bautista, Catamarca Hospital of Cordoba, Cordoba Universidade do Estado do Rio de Janeiro, Rio de Janeiro Riverside Professional Centre, Sydney, NS Copenhagen University Hospital at Hvidovre, Hvidovre King Christian the Xth Hospital, Gråsten Copenhagen University Hospital at Herlev, Herlev Al-Azhar University, Cairo Assiut University Hospital, Assiut Abo Sohage University Hospital, Sohage Tartu University Hospital, Tartu East-Tallinn Central Hospital, Tallinn Centre for Clinical and Basic Research, Tallinn Satakunta Central Hospital, Rauma University René Descartes Hôpital Cochin, Paris Dijon University Hospital University of Burgundy INSERM U887, Dijon Hôpital Lapeyronie, Montpellier Hôpital Hautepierre, Strasbourg School of Medicine National University of Athens, Athens Euroclinic Hospital, Athens Evangelisches Fachkrankenhaus, Ratingen Schlosspark-Klinik, Berlin University Medicine Berlin, Berlin Semmelweis University of Medical Sciences, Budapest Ilona Újfalussy Polyclinic of the Hospitaller Brothers of St. John of God in Budapest, Budapest St. Vincent University Hospital, Dublin Our Lady's Hospice, Dublin Department of Immunology, Lucknow Vedanta Institiute of Medical Sciences, Ahmedabad Department of Immunology Jaipur Hospital Santa Chiara Hospital, Pisa Catholic University of Sacred Heart, Rome University of Ancona, Ancona Institute of Rheumatology Tokyo Women's Medical University, Tokyo Department of Rheumatology Kyoto First Red Cross Hospital, Kyoto Shono Rheumatism Clinic, Fukuoka Kenyatta Hospital, Nairobi Pauls Stradina Clinical University Hospital, Riga Kaunas University Hospital, Kaunas El Ayachi Hospital Mohamed Vth Souissi University, Rabat Sint Franciscus Gasthuis Hospital, Rotterdam Medisch Spectrum Twente, Enschede Sørlandet Hospital, Kristiansand Medical University in Bialystok, Bialystok Medical University of Lublin, Lublin Poznan Rheumatology Centre in Srem, Srem Military Institute of Medicine, Warsaw Silesian Hospital for Rheumatology and Rehabilitation in Ustron Slaski, Ustroñ Slaski Szpital Wojewodzki im. Jana Biziela, Bydgoszcz Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko, Sopot Spitalul Clinic Sf Maria, Bucharest Institute of Rheumatology of Russian Academy of Medical Sciences, Moscow Moscow Medical Academy, Moscow Russian Medical Academy of Postgraduate Education, Moscow Rheumatology Institut, Niska Banja Hospital de Gran Canaria Dr. Negrin, Las Palmas Hospital Sierrallana Ganzo, Torrelavega Hospital General de Castellón, Castellón Uppsala University Hospital, Uppsala Centrallasarettet, Västerås Hudiksvall Medical Clinic, Hudiksvall Gazi University Medical Faculty, Ankara Meram Medical Faculty, Konya Cerrahpasa Medic Faculty, Istanbul Dubai Bone and Joint Centre, Dubai American Hospital Dubai, Dubai Charing Cross Hospital, London Royal Cornwall Hospital, Truro Kings College Hospital, London Vanderbilt University, Nashville, TN NYU Hospital for Joint Diseases, New York, NY Taylor Hospital, Ridley Park, PA Centra Care Clinic, St. Cloud, MN University of Arkansas for Medical Sciences, Little Rock, AR New York University Hospital for Joint Diseases, New York, NY Universidade Estadual de São Paulo, São Paulo
16. The Laro Kwo Project: A train the trainer model combined with mobile health technology for community health workers in Northern Uganda.
- Author
-
Ebbs D, Benson O, Jasicki S, McCollum S, and Cappello M
- Abstract
Community Health Workers (CHWs) in low and middle income countries (LMICs) provide invaluable health resources to their community members. Best practices for developing and sustaining CHW training programs in LMICs have yet to be defined using rigorous standards and measures of effectiveness. With the expansion of digital health to LMICs, few studies have evaluated the role of participatory methodologies combined with the use of mobile health (mHealth) for CHW training program development. We completed a three-year prospective observational study aligned with the development of a community-based participatory CHW training program in Northern Uganda. Twenty-five CHWs were initially trained using a community participatory training methodology combined with mHealth and a train-the-trainer model. Medical skill competency exams were evaluated after the initial training and annually thereafter to assess retention with use of mHealth. After three years, CHWs who advanced to trainer status redeveloped all program materials using a mHealth application and trained a new cohort of 25 CHWs. Implementation of this methodology coupled with longitudinal mHealth training demonstrated an improvement in medical skills over three years among the original cohort of CHWs. Further, we found that the train-the-trainer model with mHealth was highly effective, as the new cohort of 25 CHWs trained by the original CHWs exhibited higher scores when tested on medical skill competencies. The combination of mHealth and participatory methodologies can facilitate the sustainability of CHW training programs in LMIC. Further investigations should focus on comparing specific mHealth modalities for training and clinical outcomes using similar combined methodologies., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Ebbs et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2023
- Full Text
- View/download PDF
17. A case for implementation of adult pneumococcal vaccine program in Africa: review and expert opinion.
- Author
-
Shah R, Gathu C, Njenga E, Chakaya J, Ogola E, Oyoo O, Odhiambo A, Wambugu B, and Feldman C
- Subjects
- Adult, Aged, Child, Child, Preschool, Humans, Kenya epidemiology, Quality of Life, Pneumococcal Vaccines, Pneumonia, Pneumococcal
- Abstract
Vaccines are considered as a therapeutic area for children; the scientific community focuses mainly on managing chronic disease when it comes to adults. There currently is an increase in the burden of vaccine preventable illnesses in adults. Adult vaccination has been shown to dramatically increase the health and quality of life of older populations. Therefore, adult vaccinations need to be approached as a public health issue, similar to smoking cessation programs, for example. According to the Kenya Non-Communicable Diseases and injuries poverty commission report, 2018. Kenya has a high percentage of disability adjusted life years (DALYs) from communicable diseases at 63%, while non-communicable diseases (NCDs) contribute 30% of the DALYs. Specific to pneumococcal pneumonia (PP) in adults, the Global burden of disease (GBD) study in 2016 found that 2,377,697 people of all ages died from lower respiratory tract infections (LRTI) in 2016. Of these, more people died from Streptococcus pneumonia(SP) than from all other studied respiratory pathogens combined. While the incidence of LRTIs in children under five years old was reducing, partly as a result of well-established vaccination programs in children, the incidence, morbidity and mortality of PP was increasing in older populations. The expert recommendations included the following; i) all individuals 65 years of age and above, and individuals with a predisposing comorbidity regardless of age, should receive the pneumococcal vaccine; ii) several systemic modules can be emulated from the successful childhood vaccines programs onto an adult vaccine program; iii) formulation of an effective vaccine program will require collaboration from the public, the government, healthcare providers, and the media, to create awareness; iv) stakeholders who need to be involved in vaccine policy development and implementation include medical professional associations, nurses, pharmacists, clinical officers, payers (private and public insurances), government, medical learning institutions and faith-based medical organizations., Competing Interests: All the authors declare no competing interests., (Copyright: Reena Shah et al.)
- Published
- 2022
- Full Text
- View/download PDF
18. Rheumatic diseases in Africa.
- Author
-
Adelowo O, Mody GM, Tikly M, Oyoo O, and Slimani S
- Subjects
- Adult, Africa South of the Sahara epidemiology, Aged, Aged, 80 and over, Antirheumatic Agents therapeutic use, Awareness, Comorbidity, Disease Management, Environment, Female, Genetic Predisposition to Disease ethnology, Health Policy, Humans, Incidence, Male, Middle Aged, Publications supply & distribution, Rheumatic Diseases drug therapy, Rheumatic Diseases genetics, Risk Factors, Genetic Predisposition to Disease epidemiology, Publications statistics & numerical data, Rheumatic Diseases diagnosis, Rheumatic Diseases epidemiology, Rheumatologists statistics & numerical data
- Abstract
Historically, rheumatic diseases have not received much attention in Africa, particularly in sub-Saharan Africa, possibly owing to a focus on the overwhelming incidence of infectious diseases and the decreased life span of the general population in this region. Global attention and support, together with better health policies and planning, have improved outcomes for many infectious diseases; thus, increasing attention is being turned to chronic non-communicable diseases. Rheumatic diseases were previously considered to be rare among Africans but there is now a growing interest in these conditions, particularly as the number of rheumatologists on the continent increases. This interest has resulted in a growing number of publications from Africa on the more commonly encountered rheumatic diseases, as well as case reports of rare diseases. Despite the limited amount of available data, some aspects of the epidemiology, genetics and clinical and laboratory features of rheumatic diseases in African populations are known, as is some detail on the use of therapeutics. Similarities and differences in these conditions can be seen across the multi-ethnic and genetically diverse African continent, and it is hoped that increased awareness of rheumatic diseases in Africa will lead to earlier diagnosis and better outcomes for patients.
- Published
- 2021
- Full Text
- View/download PDF
19. COVID-19 and the practice of rheumatology in Africa: big changes to services from the shockwave of a pandemic.
- Author
-
Akintayo RO, Akpabio A, Kalla A, Dey D, Migowa A, Olaosebikan H, Bahiri R, El Miedany Y, Hadef D, Hamdi W, Oyoo O, Slimani S, Yerima A, Taha Y, Adebajo A, Adelowo O, Tikly M, Ghozlani I, Abdelghani KB, Fouad NA, Mosad D, El Mikkawy D, Abu-Zaid MH, and Abdel-Magied RA
- Subjects
- Humans, Hydroxychloroquine, Pandemics, SARS-CoV-2, COVID-19, Rheumatic Diseases epidemiology, Rheumatic Diseases therapy, Rheumatology
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2021
- Full Text
- View/download PDF
20. The impact of COVID-19 on rheumatology practice across Africa.
- Author
-
Akintayo RO, Akpabio AA, Kalla AA, Dey D, Migowa AN, Olaosebikan H, Bahiri R, El Miedany Y, Hadef D, Hamdi W, Oyoo O, Slimani S, Yerima A, Taha Y, Adebajo AO, Adelowo OO, Tikly M, Ghozlani I, Ben Abdelghani K, Fouad NA, Mosad D, El Mikkawy D, Abu-Zaid MH, and Abdel-Magied RA
- Subjects
- Adult, Africa, Antirheumatic Agents therapeutic use, Biological Products therapeutic use, Delivery of Health Care statistics & numerical data, Electronic Mail statistics & numerical data, Humans, Male, Middle Aged, Mobile Applications statistics & numerical data, Personal Protective Equipment, Physical Examination methods, Practice Guidelines as Topic, Registries statistics & numerical data, Rheumatic Diseases therapy, Rheumatology, SARS-CoV-2, Societies, Medical, Telemedicine statistics & numerical data, Telephone statistics & numerical data, Videoconferencing statistics & numerical data, COVID-19, Delivery of Health Care methods, Practice Patterns, Physicians' statistics & numerical data, Rheumatologists
- Abstract
Objectives: To identify the changes in rheumatology service delivery across the five regions of Africa from the impact of the COVID-19 pandemic., Methods: The COVID-19 African Rheumatology Study Group created an online survey consisting of 40 questions relating to the current practices and experiences of rheumatologists across Africa. The CHERRIES checklist for reporting results of internet e-surveys was adhered to., Results: A total of 554 completed responses were received from 20 countries, which include six in Northern Africa, six in West Africa, four in Southern Africa, three in East Africa and one in Central Africa. Consultant grade rheumatologists constituted 436 (78.7%) of respondents with a mean of 14.5 ± 10.3 years of experience. A total of 77 (13.9%) rheumatologists avoided starting a new biologic. Face-to-face clinics with the use of some personal protective equipment continued to be held in only 293 (52.9%) rheumatologists' practices. Teleconsultation modalities found usage as follows: telephone in 335 (60.5%), WhatsApp in 241 (43.5%), emails in 90 (16.3%) and video calls in 53 (9.6%). Physical examinations were mostly reduced in 295 (53.3%) or done with personal protective equipment in 128 (23.1%) practices. Only 316 (57.0%) reported that the national rheumatology society in their country had produced any recommendation around COVID-19 while only 73 (13.2%) confirmed the availability of a national rheumatology COVID-19 registry in their country., Conclusion: COVID-19 has shifted daily rheumatology practices across Africa to more virtual consultations and regional disparities are more apparent in the availability of local protocols and registries., (© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2021
- Full Text
- View/download PDF
21. Vasculitis in Africa.
- Author
-
Genga E, Oyoo O, and Adebajo A
- Subjects
- Africa epidemiology, Behcet Syndrome epidemiology, HIV Infections epidemiology, Humans, Mucocutaneous Lymph Node Syndrome epidemiology, Takayasu Arteritis epidemiology, Vasculitis virology, Vasculitis epidemiology
- Abstract
Purpose of Review: Systemic vasculitides are characterized by inflammation of blood vessel walls leading to a myriad of organ disorders depending on the size, site, and location of the affected blood vessel. The epidemiology of vasculitis in the developing world has been inadequately documented. The description of the vasculitides in Africa, both from hospital series as well as taking into consideration, previous epidemiological studies in the community, indicates that these conditions have been rare until relatively recently. In view of these past observations, this review of publications on the topic looks to shed light on the current state of vasculitis in Africa., Recent Findings: Takayasu and Kawasaki appear to be the most commonly reported vasculitides in Africa. Most of the published reports are from North and South Africa. Furthermore, the contribution of vasculitis associated with infections, and in particular HIV, is significant. There are increasing numbers of publications reflecting a growing recognition of the vasculitides in Africa.
- Published
- 2018
- Full Text
- View/download PDF
22. Africa Journal of Rheumatology: enhancing the visibility of rheumatology in Africa.
- Author
-
Genga EK, Oyoo O, Espinoza LR, and Adebajo A
- Subjects
- Africa, Periodicals as Topic, Rheumatology organization & administration
- Published
- 2017
- Full Text
- View/download PDF
23. The UWEZO project-musculoskeletal health training in Kenya.
- Author
-
Erwin J, Woolf A, Oyoo O, Cederlund I, Mwaniki L, and Etau P
- Subjects
- Health Services Accessibility, Humans, Kenya, Musculoskeletal Diseases diagnosis, Developing Countries, Musculoskeletal Diseases therapy, Rheumatology education
- Abstract
A major cause of disability and pain, musculoskeletal conditions (MSC) affect all aspects of people's lives and have a significant socioeconomic impact. Access to early diagnosis, effective treatments and rehabilitation enables people with MSCs to maintain their mobility, to work and to have a good quality of life. Despite the significant impact of MSC on health, social and economic well-being in Africa, services for MSC health remain extremely under-resourced. The UWEZO project is a collaboration between Kenyan, UK and Swedish rheumatologists, patients and researchers. It aims to improve access to basic musculoskeletal health care at the local level in communities across Kenya through the development of a sustainable training programme to raise the knowledge and skills of health professionals working in the community in the early detection, diagnosis and management of MSC. A team of physicians and patients have been trained to deliver an MSC education programme to health providers working in 11 locations across Kenya. Over 500 health providers have been trained. The programme has the potential to be adapted for use in other low resource countries where access to care for musculoskeletal conditions is limited.
- Published
- 2016
- Full Text
- View/download PDF
24. The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program.
- Author
-
Grøn KL, Ornbjerg LM, Hetland ML, Aslam F, Khan NA, Jacobs JW, Henrohn D, Rasker JJ, Kauppi MJ, Lang HC, Mota LM, Aggarwal A, Yamanaka H, Badsha H, Gossec L, Cutolo M, Ferraccioli G, Gremese E, Bong Lee E, Inanc N, Direskeneli H, Taylor P, Huisman M, Alten R, Pohl C, Oyoo O, Stropuviene S, Drosos AA, Kerzberg E, Ancuta C, Mofti A, Bergman M, Detert J, Selim ZI, Abda EA, Rexhepi B, and Sokka T
- Subjects
- Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid economics, Chi-Square Distribution, Comorbidity, Cost of Illness, Fatigue diagnosis, Fatigue economics, Female, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prevalence, Risk Factors, Severity of Illness Index, Socioeconomic Factors, Arthritis, Rheumatoid epidemiology, Disability Evaluation, Fatigue epidemiology, Gross Domestic Product, Surveys and Questionnaires
- Abstract
Objectives: The aim is to assess the prevalence of comorbidities and to further analyse to which degree fatigue can be explained by comorbidity burden, disease activity, disability and gross domestic product (GDP) in patients with rheumatoid arthritis (RA)., Methods: Nine thousands eight hundred seventy-four patients from 34 countries, 16 with high GDP (>24.000 US dollars [USD] per capita) and 18 low-GDP countries (<24.000 USD) participated in the Quantitative Standard monitoring of Patients with RA (QUEST-RA) study. The prevalence of 31 comorbid conditions, fatigue (0-10 cm visual analogue scale [VAS] [10=worst]), disease activity in 28 joints (DAS28), and physical disability (Health Assessment Questionnaire score [HAQ]) were assessed. Univariate and multivariate linear regression analyses were performed to assess the association between fatigue and comorbidities, disease activity, disability and GDP., Results: Overall, patients reported a median of 2 comorbid conditions of which hypertension (31.5%), osteoporosis (17.6%), osteoarthritis (15.5%) and hyperlipidaemia (14.2%) were the most prevalent. The majority of comorbidities were more common in high-GDP countries. The median fatigue score was 4.4 (4.8 in low-GDP countries and 3.8 in high-GDP countries, p<0.001). In low-GDP countries 25.4% of the patients had a high level of fatigue (>6.6) compared with 23.0% in high-GDP countries (p<0.001). In univariate analysis, fatigue increased with increasing number of comorbidities, disease activity and disability in both high- and low-GDP countries. In multivariate analysis of all countries, these 3 variables explained 29.4% of the variability, whereas GDP was not significant., Conclusions: Fatigue is a widespread problem associated with high comorbidity burden, disease activity and disability regardless of GDP.
- Published
- 2014
25. Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database.
- Author
-
Naranjo A, Toloza S, Guimaraes da Silveira I, Lazovskis J, Hetland ML, Hamoud H, Peets T, Mäkinen H, Gossec L, Herborn G, Skopouli FN, Rojkovich B, Aggarwal A, Minnock P, Cazzato M, Yamanaka H, Oyoo O, Rexhepi S, Andersone D, Baranauskaite A, Hajjaj-Hassouni N, Jacobs JW, Haugeberg G, Sierakowski S, Ionescu R, Karateew D, Dimic A, Henrohn D, Gogus F, Badsha H, Choy E, Bergman M, and Sokka T
- Subjects
- Cross-Sectional Studies, Databases as Topic, Disability Evaluation, Female, Humans, Male, Middle Aged, Multivariate Analysis, Arthritis, Rheumatoid physiopathology, International Cooperation, Severity of Illness Index, Smoking adverse effects
- Abstract
Objectives: To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status., Methods: The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as 'never smoked', 'currently smoking' and 'former smokers'. Patient groups with different smoking status were compared for demographic and RA measures., Results: Among the 7,307 patients with smoking data available, status as 'never smoked,' 'current smoker' and 'former smoker' were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1.17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category)., Conclusions: RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).
- Published
- 2010
26. Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA study.
- Author
-
Sokka T, Kautiainen H, Pincus T, Verstappen SM, Aggarwal A, Alten R, Andersone D, Badsha H, Baecklund E, Belmonte M, Craig-Müller J, da Mota LM, Dimic A, Fathi NA, Ferraccioli G, Fukuda W, Géher P, Gogus F, Hajjaj-Hassouni N, Hamoud H, Haugeberg G, Henrohn D, Horslev-Petersen K, Ionescu R, Karateew D, Kuuse R, Laurindo IM, Lazovskis J, Luukkainen R, Mofti A, Murphy E, Nakajima A, Oyoo O, Pandya SC, Pohl C, Predeteanu D, Rexhepi M, Rexhepi S, Sharma B, Shono E, Sibilia J, Sierakowski S, Skopouli FN, Stropuviene S, Toloza S, Valter I, Woolf A, and Yamanaka H
- Subjects
- Databases, Factual, Fatigue, Female, Global Health, Health Status, Humans, Insurance, Disability statistics & numerical data, Male, Middle Aged, Occupational Medicine statistics & numerical data, Pain, Severity of Illness Index, Surveys and Questionnaires, Work Capacity Evaluation, Arthritis, Rheumatoid physiopathology, Disability Evaluation, Persons with Disabilities, Employment statistics & numerical data
- Abstract
Introduction: Work disability is a major consequence of rheumatoid arthritis (RA), associated not only with traditional disease activity variables, but also more significantly with demographic, functional, occupational, and societal variables. Recent reports suggest that the use of biologic agents offers potential for reduced work disability rates, but the conclusions are based on surrogate disease activity measures derived from studies primarily from Western countries., Methods: The Quantitative Standard Monitoring of Patients with RA (QUEST-RA) multinational database of 8,039 patients in 86 sites in 32 countries, 16 with high gross domestic product (GDP) (>24K US dollars (USD) per capita) and 16 low-GDP countries (<11K USD), was analyzed for work and disability status at onset and over the course of RA and clinical status of patients who continued working or had stopped working in high-GDP versus low-GDP countries according to all RA Core Data Set measures. Associations of work disability status with RA Core Data Set variables and indices were analyzed using descriptive statistics and regression analyses., Results: At the time of first symptoms, 86% of men (range 57%-100% among countries) and 64% (19%-87%) of women <65 years were working. More than one third (37%) of these patients reported subsequent work disability because of RA. Among 1,756 patients whose symptoms had begun during the 2000s, the probabilities of continuing to work were 80% (95% confidence interval (CI) 78%-82%) at 2 years and 68% (95% CI 65%-71%) at 5 years, with similar patterns in high-GDP and low-GDP countries. Patients who continued working versus stopped working had significantly better clinical status for all clinical status measures and patient self-report scores, with similar patterns in high-GDP and low-GDP countries. However, patients who had stopped working in high-GDP countries had better clinical status than patients who continued working in low-GDP countries. The most significant identifier of work disability in all subgroups was Health Assessment Questionnaire (HAQ) functional disability score., Conclusions: Work disability rates remain high among people with RA during this millennium. In low-GDP countries, people remain working with high levels of disability and disease activity. Cultural and economic differences between societies affect work disability as an outcome measure for RA.
- Published
- 2010
- Full Text
- View/download PDF
27. Infection-related vasculitis.
- Author
-
Oyoo O and Espinoza LR
- Subjects
- HIV Infections, Hepatitis B prevention & control, Hepatitis C, Chronic drug therapy, Humans, Polyarteritis Nodosa virology, Vaccination adverse effects, Vasculitis etiology, Virus Diseases, Infections, Vasculitis microbiology
- Abstract
Infection-related vasculitis constitutes the most common cause of secondary vasculitis. A great variety of microorganisms can induce directly or indirectly inflammatory vascular damage resulting in vascular occlusion, tissue ischemia, and necrosis. In the developed world hepatitis B and C-related vasculitis remain the most common clinical syndromes, while HIV-associated vasculitis remains a concern in developing countries.
- Published
- 2005
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.