1. Corrigendum: Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy (Scientific Reports (2017) 7 (43953) DOI: 10.1038/srep43953)
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Martínez Berriochoa, Agustín, Unzurrunzaga, Ainhoa, Hidalgo Conde, Ana, Vuelta, Ana Belén Madroñero, Fernández Nebro, Antonio, Carmen Ordóñez Cañizares, M., Fernández Gutiérrez, Benjamín, Rodríguez Rodríguez, Luis, Escalante, Begoña, Alfonso, Begoña Marí, Sopeña, Bernardo, Gómez Vaquero, Carmen, Raya, Enrique, Grau, Elena, Román, José A., Vicente, Esther F., Miguel, Eugenio de, López Longo, Francisco J., Martínez, Lina, Morado, Inmaculada C., Bernardino Díaz López, J., Caminal Montero, Luis, Martínez Zapico, Aleida, Narváez, Javier, Monfort, Jordi, Tío, Laura, Filloy, José A. Miranda, Sánchez Martín, Julio, Alegre Sancho, Juan J., Sáez Comet, Luis, Conesa, Mercedes Pérez, Corbera Bellalta, Marc, Ramentol Sintas, Marc, García Villanueva, María Jesús, Rojas, Mercedes Guijarro, Ortego Centeno, Norberto, Fernández, Raquel Ríos, Callejas, José Luis, Pernaute, Olga Sanchez, Mateo, Patricia Fanlo, Blanco, Ricardo, González, Sergio Prieto, Soriano, Víctor Manuel Martínez T.a.b.o.a.d.a.1.1. Alessandra, Lunardi, Claudio, Gianfreda, Davide, Santilli, Daniele, Bonatti, Francesco, Muratore, Francesco, Pazzola, Giulia, ADDIMANDA, OLGA, Emmi, Giacomo, Ramirez, Giuseppe A., Beretta, Lorenzo, Govoni, Marcello, Onat, Marco A. C.i.m.m.i.n.o.5.2. Ahmet Mesut, Cefle, Ayse, Yazici, Ayten, Kısacık, Bünyamin, Dalkilic, Ediz, Seyahi, Emire, Fresko, Izzet, Tunc, Ercan, Erken, Eren, Ozer, Hüseyin TE, Aksu, Kenan, Keser, Gokhan, Ozturk, Mehmet A., Bıcakcıgil, Muge, Duzgun, Nurşen, Karadag, Omer, Kiraz, Sedat, Pamuk, Ömer N., Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Kamali, Sevil, Inanc, Murat, Yentür, Sibel P., Aydin, Sibel Z., Alibaz Oner, Fatma, Kaşifoğlu, Timuçin, Cobankara, Veli, Ozbalkan, Zeynep, Ates, Askin, Carette, Yasar K.a.r.a.a.s.l.a.n.7.3. Simon, Chung, Sharon A., Cuthbertson, David, Forbess, Lindsay J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., Mcalear, Carol A., McKinnon Maksimowicz, Kathleen, Monach, Paul A., Moreland, Larry, Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg87, Steven R. ., Martínez-Berriochoa, Agustín, Unzurrunzaga, Ainhoa, Hidalgo-Conde, Ana, Vuelta, Ana Belén Madroñero, Fernández-Nebro, Antonio, Carmen Ordóñez-Cañizares, M., Fernández-Gutiérrez, Benjamín, Rodríguez-Rodríguez, Lui, Escalante, Begoña, Alfonso, Begoña Marí, Sopeña, Bernardo, Gómez-Vaquero, Carmen, Raya, Enrique, Grau, Elena, Román, José A., Vicente, Esther F., Miguel, Eugenio de, López-Longo, Francisco J., Martínez, Lina, Morado, Inmaculada C., Bernardino Díaz-López, J., Caminal-Montero, Lui, Martínez-Zapico, Aleida, Narváez, Javier, Monfort, Jordi, Tío, Laura, Filloy, José A. Miranda, Sánchez-Martín, Julio, Alegre-Sancho, Juan J., Sáez-Comet, Lui, Conesa, Mercedes Pérez, Corbera-Bellalta, Marc, Ramentol-Sintas, Marc, García-Villanueva, María Jesú, Rojas, Mercedes Guijarro, Ortego-Centeno, Norberto, Fernández, Raquel Río, Callejas, José Lui, Pernaute, Olga Sanchez, Mateo, Patricia Fanlo, Blanco, Ricardo, González, Sergio Prieto, Soriano, Víctor Manuel Martínez-Taboada11.Alessandra, Lunardi, Claudio, Gianfreda, Davide, Santilli, Daniele, Bonatti, Francesco, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Emmi, Giacomo, Ramirez, Giuseppe A., Beretta, Lorenzo, Govoni, Marcello, Onat, Marco A. Cimmino52. Ahmet Mesut, Cefle, Ayse, Yazici, Ayten, Kısacık, Bünyamin, Dalkilic, Ediz, Seyahi, Emire, Fresko, Izzet, Tunc, Ercan, Erken, Eren, Ozer, Hüseyin TE, Aksu, Kenan, Keser, Gokhan, Ozturk, Mehmet A., Bıcakcıgil, Muge, Duzgun, Nurşen, Karadag, Omer, Kiraz, Sedat, Pamuk, Ömer N., Akar, Servet, Onen, Fato, Akkoc, Nurullah, Kamali, Sevil, Inanc, Murat, Yentür, Sibel P., Aydin, Sibel Z., Alibaz-Oner, Fatma, Kaşifoğlu, Timuçin, Cobankara, Veli, Ozbalkan, Zeynep, Ates, Askin, Carette, Yasar Karaaslan73. Simon, Chung, Sharon A., Cuthbertson, David, Forbess, Lindsay J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., Mcalear, Carol A., McKinnon-Maksimowicz, Kathleen, Monach, Paul A., Moreland, Larry, Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., and Ytterberg87, Steven R. .
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Multidisciplinary ,skin and connective tissue diseases - Abstract
Giant cell arteritis (GCA) and Takayasu’s arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/ MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P = 7.54E-07; ORGCA = 1.19, ORTAK = 1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA = 5.52E-04, ORGCA = 1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus.
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- 2017