143 results on '"P, Farnarier"'
Search Results
2. Type III procollagen is a reliable marker of ARDS-associated lung fibroproliferation
- Author
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Forel, Jean-Marie, Guervilly, Christophe, Hraiech, Sami, Voillet, François, Thomas, Guillemette, Somma, Claude, Secq, Véronique, Farnarier, Catherine, Payan, Marie-Josée, Donati, Stéphanie-Yannis, Perrin, Gilles, Trousse, Delphine, Dizier, Stéphanie, Chiche, Laurent, Baumstarck, Karine, Roch, Antoine, and Papazian, Laurent
- Published
- 2015
- Full Text
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3. MR imaging of fetal brain malformations
- Author
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Raybaud, Charles, Levrier, Olivier, Brunel, Hervé, Girard, Nadine, and Farnarier, Philippe
- Published
- 2003
- Full Text
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4. Schizencephaly: correlation between the lobar topography of the cleft(s) and absence of the septum pellucidum
- Author
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Raybaud, C., Girard, N., Lévrier, O., Peretti-Viton, P., Manera, L., and Farnarier, P.
- Published
- 2001
- Full Text
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5. Immune reconstitution and outcome after unrelated cord blood transplantation: a single paediatric institution experience
- Author
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Giraud, P, Thuret, I, Reviron, D, Chambost, H, Brunet, C, Novakovitch, G, Farnarier, C, and Michel, G
- Published
- 2000
- Full Text
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6. Increased Levels of Soluble Adhesion Molecules in the Serum of Patients with Hepatitis C (Correlation with Cytokine Concentrations and Liver Inflammation and Fibrosis)
- Author
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Kaplanski, Gilles, Farnarier, Catherine, Payan, Marie-Josee, Bongrand, Pierre, and Durand, Jean-Marc
- Published
- 1997
- Full Text
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7. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
- Author
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. 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M., Pleiffer, G., Kunre, K., Dieterich, M., Brandt, Th., Guarino, M., Stracciari, A., Pazzaglia, P., D'Alessandro, R., Santilli, I., Donato, M., The European Velnacrine Study Group, The Dutch Guillain-Barré study group, The COP-1 Multicenter Clinical and Research Group Study, and European Study Group
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- 1994
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8. Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation
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Piperoglou, Christelle, Larid, Guillaume, Vallentin, Blandine, Balligand, Laura, Crinier, Adeline, Banzet, Nathalie, Farnarier, Catherine, Gomez‐Massa, Elena, Adalia, Aranzazu Cruz, Michel, Gérard, Galambrun, Claire, Barlogis, Vincent, Vivier, Eric, and Vély, Frédéric
- Abstract
Lymphocytes are essential for microbial immunity, tumor surveillance, and tissue homeostasis. However, the in vivodevelopment and function of helper‐like innate lymphoid cells (ILCs) in humans remain much less well understood than those of T, B, and NK cells. We monitored hematopoietic stem cell transplantation (HSCT) to determine the kinetics of ILC development in both children and adults. It was found that, unlike NK cells, helper‐like ILCs recovered slowly, mirroring the pattern observed for T cells, with normalization achieved at 1 year. The type of graft and the proportion of CD34+cells in the graft did not significantly affect ILC reconstitution. As HSCT is often complicated by acute or chronic graft‐versus‐host disease (GVHD), the potential role of ILC subsets in maintaining tissue integrity in these conditions was also analyzed. It was found that GVHD was associated with lower levels of activated and gut‐homing NKp44+ILCP, consistent with a non‐redundant role of this ILC subset in preventing this life‐threatening disorder in lymphopenic conditions. Patients with graft‐versus‐host disease after hematopoietic stem cell transplantation showed slow recovery of circulating innate lymphoid cells and a reduced number of activated ILCP; this is consistent with a non‐redundant role of this ILC subset in preventing this life‐threatening disorder under lymphopenic conditions.
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- 2022
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9. Functional and genetic testing in adults with HLH reveals an inflammatory profile rather than a cytotoxicity defect
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Carvelli, Julien, Piperoglou, Christelle, Farnarier, Catherine, Vely, Frédéric, Mazodier, Karin, Audonnet, Sandra, Nitschke, Patrick, Bole-Feysot, Christine, Boucekine, Mohamed, Cambon, Audrey, Hamidou, Mohamed, Harle, Jean-Robert, de Saint Basile, Geneviève, and Kaplanski, Gilles
- Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory condition. Primary HLH occurs early in life as a result of monogenic biallelic mutations affecting lymphocyte cytotoxicity. Secondary HLH occurs mostly in adults secondary to infection, lymphoma, or rheumatic disease. In this latter setting, lymphocyte cytotoxicity status is not known. We conducted a systematic evaluation of natural killer (NK) cell cytotoxicity in adult patients with secondary HLH. Adult patients with secondary HLH were prospectively studied ex vivo for total lymphocyte count and subtype, NK cell phenotype, perforin expression and degranulation, and natural or antibody-dependent cell cytotoxicity, in comparison with patients affected by the same underlying disease without HLH (disease controls [DCs]) and with healthy controls (HCs). Screening for variants of cytotoxity genes was systematically performed. 68 patients were included in the HLH group and 34 each in the DC and HC groups. In HLH patients, severe and transient lymphopenia, activated NK cell phenotype (eg, increased CD69, ICAM-1, HLADR, and CCR5 expression), and decreased capacity of interferon γ production were observed; mean perforin expression was normal; and degranulation tests and NK cell cytotoxicity were not different from those in DCs. A monoallelic variant of uncertain significance affecting a lymphocyte cytotoxicity gene or the perforin variant A91V was observed in almost 50% of the patients. We detected no major intrinsic cytotoxicity dysfunction in secondary HLH patients compared with DCs and no predicted pathogenic gene variant. The activated NK phenotype profile associated with decreased interferon γ production seems similar to those of other hyperinflammatory diseases such as sepsis or systemic juvenile idiopathic arthritis.
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- 2020
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10. Embolization of an intraparotid false aneurysm of the external carotid artery: Case report
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Bartoli, Jean-Michel, Triglia, Jean-Michel, Farnarier, Phillippe, Moulin, Guy, and Kasbarian, Michel
- Published
- 1991
- Full Text
- View/download PDF
11. Developmental dyslexia: atypical cortical asymmetries and functional significance
- Author
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O. Levrier, Fabrice Robichon, Michel Habib, and P. Farnarier
- Subjects
medicine.medical_specialty ,Planum temporale ,Dyslexia ,Parietal lobe ,Inferior frontal gyrus ,Phonological deficit ,Audiology ,medicine.disease ,behavioral disciplines and activities ,Lateralization of brain function ,Neurology ,Frontal lobe ,medicine ,Neurology (clinical) ,medicine.symptom ,Broca's area ,Psychology ,Cognitive psychology - Abstract
Using brain magnetic resonance imaging, we measured in 16 young developmental dyslexic adults and 14 age-matched controls cortical asymmetries of posterior language-related areas, including Planum temporale and parietal operculum cortical ribbon, and of the inferior frontal region related in the left hemisphere to speech processing. In addition, we assessed the sulcal morphology of the inferior frontal gyrus in both groups according to a qualitative method. The dyslexic subjects also performed specific tasks exploring different aspects of phonological and lexical-semantic processes. Results showed that: (1) contrary to most results reported in the literature, there is a lack of any morphological difference relative to Planum temporale asymmetry between the two groups; (2) there are significant differences between dyslexic and control subjects relative to frontal areas; (3) concerning the parietal region, there is a more asymmetrical pattern towards the left side in dyslexic subjects than in controls; and (4) relations in dyslexic subjects between parietal asymmetry coefficient and the level of performance in a phonological task have a particular reliance on verbal short-term memory, frontal asymmetry and performance in a non-word reading task. Considering these results it is suggested that phonological segmentation skills may relate to frontal lobe morphology, while phonological memory-based impairment in people with dyslexia may rather relate to parietal lobe morphology.
- Published
- 2000
- Full Text
- View/download PDF
12. Correlative study between computerized transverse scanning and stereoimpedoencephalography in space-occupying lesions of the brain
- Author
-
Benabid, A. L., Persat, J. C., Chirossel, J. P., de Rougemont, J., Barge, M., Salamon, G., and Farnarier, P.
- Published
- 1979
- Full Text
- View/download PDF
13. Hypoglossal artery, a rare abnormal carotid-basilar anastomosis
- Author
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Debaene, A., Farnarier, P., Dufour, M., and Legre, J.
- Published
- 1972
- Full Text
- View/download PDF
14. [Craniopharyngioma in children: MRI study of 43 cases]
- Author
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H, Brunel, C, Raybaud, P, Peretti-Viton, G, Lena, N, Girard, A, Paz-Paredes, O, Levrier, P, Farnarier, L, Manera, and M, Choux
- Subjects
Male ,Adolescent ,Brain Neoplasms ,Infant ,Radiosurgery ,Magnetic Resonance Imaging ,Craniopharyngioma ,Child, Preschool ,Humans ,Female ,Sella Turcica ,Child ,Tomography, X-Ray Computed ,Retrospective Studies ,Third Ventricle - Abstract
Craniopharyngiomas are intra-cranial tumors, relatively frequent in children, expanding in the pituitary stalk axis, from the third ventricle to the sphenoid body. Plain films and CT scan generally show a calcified lesion, deforming the sella turcica. MRI improves tumor description and topographic and structural analysis of the lesion. The aim of this study is to analyze the MRI aspect of craniopharyngiomas in a pediatric population and to correlate findings with surgical data.MR and CT studies of 43 pediatric cases of histology-proven craniopharyngiomas were reviewed retrospectively. Tumor emergence, extensions and signal on different sequences were recorded. We searched for radio-surgical correlations.Craniopharyngiomas can be classified into two groups: intra-sellar tumors and third ventricle floor tumors (infundibulum and tuber cinereum). Preferential routes of extension are observed in each group correlated with consistency (cystic and/or solid). Surgical data confirmed these results.MRI is crucial for the pre-therapeutic evaluation of craniopharyngiomas allowing not only a detailed description of the tumor but also guiding therapeutic decisions. This series demonstrated that craniopharyngiomas exhibit two different types of localization and behavior. Embryonic development of the tumor explains the topographical differences.
- Published
- 2002
15. MR Changes after Gamma Knife Radiosurgery for Mesial Temporal Lobe Epilepsy: Evidence for the Efficacy of Subnecrotic Doses
- Author
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Patrick Chauvel, Motohiro Hayashi, J. Régis, F. Bartolomei, P. Farnarier, and Marc Rey
- Subjects
business.industry ,medicine.medical_treatment ,medicine ,Gamma knife radiosurgery ,business ,Nuclear medicine ,Mesial temporal lobe epilepsy ,Radiosurgery - Published
- 2002
- Full Text
- View/download PDF
16. [Gamma-knife radiosurgery for brainstem arteriovenous malformations. Preliminary results]
- Author
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J, Régis, N, Massager, O, Lévrier, H, Dufour, D, Porcheron, N, Reyns, J C, Peragut, and P, Farnarier
- Subjects
Adult ,Intracranial Arteriovenous Malformations ,Male ,Risk ,Adolescent ,Middle Aged ,Radiosurgery ,Treatment Outcome ,Disease Progression ,Humans ,Brain Damage, Chronic ,Female ,France ,Child ,Aged ,Brain Stem ,Cerebral Hemorrhage ,Retrospective Studies ,Ultrasonography - Abstract
Microsurgical resection have the advantage to be immediately effective according to bleeding risk and is the reference treatment for cerebral arteriovenous malformations. For cerebral arteriovenous malformations located in the brainstem gamma-knife radiosurgery due to its low invasivity is classically a first line treatment. We reviewed the Marseilles experience to assess the efficacy and safety of gamma-knife radiosurgery for brain stem arteriovenous malformations.We analyzed retrospectively data of 45 patients with an arteriovenous malformation located in the brain stem treated in Marseilles by gamma-knife radiosurgery by between 07/92 and 12/99. Mean age was 42 years, there were 5 children. Arteriovenous malformations were located in the pons or midbrain for the majority of the patients. Intraaxial lesion was found in 82% of patients. Hemorrhage prior to radiosurgery occurred in 75% of the patients. Gamma-knife procedure was the first treatment of the arteriovenous malformations for 29 patients (65%); previous surgery was performed in 34 patients (15%). Mean nidus volume was 550 mm(3) (32-14 196 mm(3)). Mean margin dose was of 23 Gy (range 15-30 Gy). Follow up was available for 25 patients (mean 18 months).One patient presented a transient worsening of his neurological status, and 2 patients developed a fixed deficit. Two patients underwent rebleeding at an interval of 12 to 36 months after the gamma-knife procedure. At last angiographic follow-up (13 patients), the obliteration rate was 82% of the arteriovenous malformations. A second procedure was proposed to a patient with only partial occlusion at 3 years.Gamma-knife radiosurgery can achieve good obliteration rate of brain stem arteriovenous malformations with low morbidity and may be a valuable first-choice therapy for such arteriovenous malformations. A larger population and longer follow up are mandatory in order to confirm these preliminary results.
- Published
- 2001
17. Developmental dyslexia: atypical cortical asymmetries and functional significance
- Author
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F, Robichon, O, Levrier, P, Farnarier, and M, Habib
- Subjects
Adult ,Cerebral Cortex ,Dyslexia ,Male ,Analysis of Variance ,Reading ,Parietal Lobe ,Humans ,Neuropsychological Tests ,Magnetic Resonance Imaging ,Functional Laterality ,Temporal Lobe ,Frontal Lobe - Abstract
Using brain magnetic resonance imaging, we measured in 16 young developmental dyslexic adults and 14 age-matched controls cortical asymmetries of posterior language-related areas, including Planum temporale and parietal operculum cortical ribbon, and of the inferior frontal region related in the left hemisphere to speech processing. In addition, we assessed the sulcal morphology of the inferior frontal gyrus in both groups according to a qualitative method. The dyslexic subjects also performed specific tasks exploring different aspects of phonological and lexical-semantic processes. Results showed that: (1) contrary to most results reported in the literature, there is a lack of any morphological difference relative to Planum temporale asymmetry between the two groups; (2) there are significant differences between dyslexic and control subjects relative to frontal areas; (3) concerning the parietal region, there is a more asymmetrical pattern towards the left side in dyslexic subjects than in controls; and (4) relations in dyslexic subjects between parietal asymmetry coefficient and the level of performance in a phonological task have a particular reliance on verbal short-term memory, frontal asymmetry and performance in a non-word reading task. Considering these results it is suggested that phonological segmentation skills may relate to frontal lobe morphology, while phonological memory-based impairment in people with dyslexia may rather relate to parietal lobe morphology.
- Published
- 2000
18. Value of MRI in the morphological evaluation of tumors of the third ventricle
- Author
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O, Levrier, P, Farnarier, J C, Peragut, P, Peretti, C, Rumeau, A M, Perez-Castillo, and G, Salamon
- Subjects
Adult ,Male ,Brain Diseases ,Adolescent ,Cysts ,Teratoma ,Dysgerminoma ,Middle Aged ,Magnetic Resonance Imaging ,Cerebral Ventricles ,Humans ,Female ,Cerebral Ventricle Neoplasms ,Pinealoma - Abstract
The detection or suspicion of a tumoral expansive process in the third ventricule is usually performed by MRI. The contribution of MRI to the diagnosis is unquestionable in view of its accuracy in the topographical characterization of these lesions and in the detection of small formations. The great histological variety of tumours in that region may result in different treatments which can be associated. MRI, therefore, plays an important role in pretherapeutic morphological evaluation. Fifteen patients with tumour of the third ventricle were examined by MRI before treatment. The results of these examinations were compared with the pathological data and the therapeutic procedures: ventricular shunting, stereotactic needle biopsy, radio- or chemotherapy and surgery. MRI cannot provide a formal histological characterization, but it can individualise some categories of tumours, give details on the walls of the third ventricle (notably in the case of bifocal pineal and suprassellar lesions), visualize the paths of CSF flow and predict the need for cisternoventriculostomy, and detect venous structures in the vicinity of the great cerebral vein which might result in post-biopsy and post-surgery complications.
- Published
- 1992
19. [Paralytic pontine exotropia disclosing endocarditis]
- Author
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F, Nicoli, P, Beaurain, A, Dalecky, F, Cohen, P, Farnarier, and J L, Gastaut
- Subjects
Pons ,Exotropia ,Humans ,Female ,Endocarditis, Bacterial ,Middle Aged ,Tomography, X-Ray Computed ,Magnetic Resonance Imaging ,Brain Ischemia - Abstract
A case of bacterial endocarditis complicated by paralytic pontine exotropia is reported. Magnetic resonance imaging clearly showed a rostral lesion of the paramedial pontine reticular formation and the medial longitudinal fasciculus. The occurrence of paralytic pontine exotropia is suggestive of ischaemia, and patients with this so-called "one-and-a-half syndrome" associated with signs of infection should be investigated for endocarditis.
- Published
- 1992
20. [Hemichorea in acquired immunodeficiency syndrome. Toxoplasmosis abscess in the striatum]
- Author
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P, Pestre, L, Milandre, P, Farnarier, and H, Gallais
- Subjects
Adult ,Male ,Acquired Immunodeficiency Syndrome ,Chorea ,Toxoplasmosis, Cerebral ,Humans ,Female ,Corpus Striatum - Abstract
Three HIV seropositive patients presented with cerebral toxoplasmosis which was treated by anti-infectious agents. After partial improvement, they developed hemichorea related to striatal infectious lesions. In AIDS patients with cerebral toxoplasmosis, autopsy series have reported a high incidence of basal ganglia abscesses, explaining the occurrence of involuntary movements such as hemichorea.
- Published
- 1991
21. [Colloid cysts of the third cerebral ventricle. Computed x-ray tomography, MRI and stereotaxic puncture. Apropos of 9 cases]
- Author
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J C, Peragut, J M, Riss, P, Farnarier, D, Gambarelli, and M, Sethian
- Subjects
Adult ,Male ,Brain Diseases ,Adolescent ,Cysts ,Punctures ,Middle Aged ,Magnetic Resonance Imaging ,Cerebral Ventricles ,Stereotaxic Techniques ,Humans ,Female ,Tomography, X-Ray Computed ,Follow-Up Studies - Abstract
The authors report their experience with Colloid Cysts of the third ventricle (9 cases treated between 1983 and 1989). Eight of them were punctured using stereotactic approach; five cysts were completely evacuated and the patients are free of recurrence. In three cases, tapping was impossible or the cyst insufficiently evacuated and the patients were secondary operated on (open microsurgical approach). The last case was directly operated on. Colloid cysts cured by stereotactic puncture were all hypo or iso-dense at C.T. scan and had a diameter of more than 1 cm. All these cases have had a M.R.I. exploration and the image of the cyst was always the same increased T1 and T2 signal. Unfortunately, we did not have the opportunity to realize M.R.I. in colloid cysts of a small size and hyperdense at C.T. scan. These results can help to the indication of a stereotactic puncture at the first attempt in some well defined colloid cysts.
- Published
- 1990
22. Subject Index Vol. 66, Suppl. 1, 1996
- Author
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G. Pendl, A. Pasoli, Zheng-qing Hu, W.Y. Chung, K.A. Leber, L. Widén, C.M. Duma, X. Wu, L. Kihlström, G. Pencil, S. Kawamoto, C.B. Chasan, Y.J. Lim, K. Takakura, M. Rossato, T. Tsuzuki, K. Suzuki, A.A. Kemeny, O. Major, S. Takai, M. Hirato, A. Nieoullon, S. Nakayama, H. Oyama, J. Hirato, J.C. Flickinger, T. Sakaki, M.M.H. Teng, V.P. Collins, A.H. Morice, I. Lax, R. Nicoletti, J. Russell, H.K. Inoue, Y. Andou, T. Kawamata, M. Rigotti, A. Bricolo, B. Masotto, S. Fukuoka, Y. Sasaki, S. Goetsch, T.D. Nichols, Y. Seo, Y.L. Lee, H. Sato, T. Hardy, Gene H. Barnett, S. Nakamura, S. Tsunoda, W. Leem, R. Sartori, J.A. Fiedler, W.P. Gwan, N. Konishi, D.M.C. Forster, M. Vial, M. Söderman, T. Kobayashi, G. Marchini, S. Babighian, C. Lindquist, M. Dal Sasso, S. Stone-Elander, Y. Umebara, F. Severi, Bin-Jiang Wang, M. Izawa, Jia-Zhong Dai, W.Y. Guo, M. Habeck, S. Takahashi, A. Pasqualin, P. Ferraresi, Y. Kwon, M. Ide, G. Barone, L. Manera, D.E. Schwartz, Xing-Rong Chen, W.R. Hudgins, A. Posewitz, S.J. Goetsch, Y. Hiasa, A. Benati, J. Nakagawara, Y. Imahori, S.S. Vermeulen, Y. Ohmori, E. Yoshino, J.C. Peragut, O. Chinot, C. Ohye, G.M. Friehs, M. Hayashi, R. Foroni, L.D. Lunsford, J. Jakubowski, L.K. Kerkerian-Legoff, B. Karlsson, A. Hampshire, Y. Kida, J. Mogard, O. Levrier, H.C. Pan, T. Yamaki, H. Tung, E. Kato, J. Régis, J. Plombon, J.L. Barker, Liang-fu Zhou, Zi-wei Gao, Y. Aoki, H. Fujino, S. Eustacchio, G. Norén, P. Grimm, H. Kohga, A. Lizarraras, E. Piovan, P. Farnarier, L. Bonomi, S. Hagiwara, H.J. Landy, S. Matsubara, M. Rey, M. Jimbo, D. Kondziolka, J.C. Ganz, J. Nakamura, J.Y. Ting, A. Nicolato, T. Tanaka, R.F. Young, M. Tago, K. Kitz, L.W. Wang, C.Y. Chang, C.J. Whang, Li Pan, J. Peragut, A.M. Markoe, T. Shibazaki, H. Nagano, C. Scharfen, K. Suematsu, R. Aigner, E. Maurincomme, A. Terahara, Ren-He Dong, D. Porcheron, T. Hirai, M. Nakamura, M. Yamamoto, L. Walton, K. Nakagawa, S. Furuya, H. Kurita, Wei-ming Xu, S. Naruse, G.F. Fueger, T. Higuchi, W.C. Chu, Wei-min Xu, K. Ott, A. Zama, O. Schröttner, H. Hiyama, H. Inoue, S. Murayama, R. Marks, G.P. Urbani, S. Ueda, K. Tanohata, K. Ericson, D. Hodgens, K. Nakaya, M. Niwa, T. Mori, M.C. Wu, K. Arai, M. Gerosa, and M. Takanashi
- Subjects
Index (economics) ,business.industry ,Medicine ,Surgery ,Subject (documents) ,Neurology (clinical) ,business ,Neuroscience ,Clinical psychology - Published
- 1996
- Full Text
- View/download PDF
23. Evidence of innate lymphoid cell redundancy in humans
- Author
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Vély, Frédéric, Barlogis, Vincent, Vallentin, Blandine, Neven, Bénédicte, Piperoglou, Christelle, Ebbo, Mikael, Perchet, Thibaut, Petit, Maxime, Yessaad, Nadia, Touzot, Fabien, Bruneau, Julie, Mahlaoui, Nizar, Zucchini, Nicolas, Farnarier, Catherine, Michel, Gérard, Moshous, Despina, Blanche, Stéphane, Dujardin, Arnaud, Spits, Hergen, Distler, Jörg H W, Ramming, Andreas, Picard, Capucine, Golub, Rachel, Fischer, Alain, and Vivier, Eric
- Abstract
Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common γ-chain cytokine receptor subunit IL-2Rγ or the gene encoding the tyrosine kinase JAK3. T cell reconstitution was observed in patients with SCID after hematopoietic stem cell transplantation (HSCT), but the patients still had considerably fewer ILCs in the absence of myeloablation than did healthy control subjects, with the exception of rare cases of reconstitution of the ILC1 subset of ILCs. Notably, the ILC deficiencies observed were not associated with any particular susceptibility to disease, with follow-up extending from 7 years to 39 years after HSCT. We thus report here selective ILC deficiency in humans and show that ILCs might be dispensable in natural conditions, if T cells are present and B cell function is preserved.
- Published
- 2016
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- View/download PDF
24. Des médiateurs de santé pairs dans une équipe mobile en santé mentale. Entre rétablissement et professionnalisation, une quête de légitimité.
- Author
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SARRADON-ECK, ALINE, FARNARIER, CYRIL, GIRARD, VINCENT, HÄNDLHUBER, HERMANN, LEFEBVRE, CLAUDE, SIMONET, ÉGLANTINE, and STAES, BERNARD
- Subjects
MENTAL health personnel ,MEDIATORS (Persons) ,MENTAL health services for homeless people ,FACILITATORS (Persons) ,MEDIATION ,MENTAL health services ,MENTAL health ,HOSPITAL personnel ,HOMELESS shelters ,HOSPITALS - Abstract
Copyright of Lien Social et Politiques is the property of Institut National de Recherche Scientifique (INRS) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2012
- Full Text
- View/download PDF
25. The endothelial cholesterol efflux is promoted by the high-density lipoprotein anionic peptide factor.
- Author
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Domingo, Nicole, Mastellone, Isabelle, Grès, Sandra, Marin, Valérie, Lorec, Anne Marie, Tosini, Frédéric, Grosclaude, Jeanne, Farnarier, Catherine, and Chanussot, Françoise
- Subjects
ISOPENTENOIDS ,CHOLESTEROL ,ATHEROSCLEROSIS ,CELLS - Abstract
Abstract: The prevention of atherosclerosis depends on the high-density lipoprotein (HDL) capacity to stimulate the efflux of unesterified cholesterol (UC). We tested here the effects of 2 HDL apolipoproteins, apo A-I and the 7-kd anionic peptide factor (APF), on the UC efflux by human endothelial ECV 304 cells in culture. Apolipoprotein A-I (10 μmol/L) or APF (3.5 μmol/L) in lipid-free forms or small particles (13 nm with apo A-I or 19 nm with APF) were incubated in the presence of [4-
14 C]UC. The phosphatidylcholines (PCs) were present either at a low level (0.35 mmol/L with apo A-I or 0.20 mmol/L with APF) or at a high level (1 mmol/L with apo A-I). We also tested either large 53-nm bile lipoprotein complex–like particles (3.5 μmol/L APF [13 μg/500 μL]) with a high PC level (0.65 mmol/L) or a 9-residue synthetic peptide (13 μg/500 μL), derived from the NH2 -terminal domain of HDL3 -APF, in a lipid-free or low-lipidated (0.20 mmol/L PCs) form. A control was developed in absence of the added compounds. A rapid [4-14 C]UC efflux mediated by APF added in free form or in 19-nm complexes was 2.2- to 2.3-fold higher than that mediated by apo A-I in free form or in 13-nm particles (P < .05). The level of this high APF-related efflux was comparable with that obtained with the 12-nm native HDLs (10 μmol/L apo A-I) or free PCs (1 mmol/L). The increase in the UC efflux was much more limited (1.4-fold) in the presence of the 53-nm APF/high-PC particles, but it was higher than that mediated by apo A-I. In addition, the efflux mediated by the synthetic peptide, in lipid-free or low-lipidated form, constituted the major part of that related to the full-length APF. Thus, all these particles are very active HDL components, able to act as cholesterol acceptors. Interestingly, we further showed a new anti-atherogenic property of APF as well as its metabolic importance and clinical relevance. By its involvement in the first step of the reverse cholesterol transport, APF could reduce the risk of cardiovascular disease. [Copyright &y& Elsevier]- Published
- 2005
- Full Text
- View/download PDF
26. Induction of B7-H6, a ligand for the natural killer cell–activating receptor NKp30, in inflammatory conditions
- Author
-
Matta, Jessica, Baratin, Myriam, Chiche, Laurent, Forel, Jean-Marie, Cognet, Céline, Thomas, Guillemette, Farnarier, Catherine, Piperoglou, Christelle, Papazian, Laurent, Chaussabel, Damien, Ugolini, Sophie, Vély, Frédéric, and Vivier, Eric
- Abstract
B7-H6, a member of the B7 family of immunoreceptors, is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. B7-H6 is not detected in normal human tissues at steady state but is expressed on tumor cells. However, whether B7-H6 can be expressed in other conditions remains unknown. We analyzed here the pathways that lead to the expression of B7-H6 in nontransformed cells. In vitro, B7-H6 was induced at the surface of CD14+CD16+proinflammatory monocytes and neutrophils upon stimulation by ligands of Toll-like receptors or proinflammatory cytokines such as interleukin-1β and tumor necrosis factor α. In these conditions, a soluble form of B7-H6 (sB7-H6) was also produced by activated monocytes and neutrophils. In vivo, B7-H6 was expressed on circulating proinflammatory CD14+CD16+monocytes in a group of patients in sepsis conditions, and was linked to an increased mortality. sB7-H6 was selectively detected in the sera of patients with gram-negative sepsis and was associated with membrane vesicles that co-sedimented with the exosomal fraction. These findings reveal that B7-H6 is not only implicated in tumor immunosurveillance but also participates in the inflammatory response in infectious conditions. This trial was registered at www.clinicaltrials.govas #NTC00699868.
- Published
- 2013
- Full Text
- View/download PDF
27. Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome
- Author
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Mazodier, Karin, Marin, Valérie, Novick, Daniela, Farnarier, Catherine, Robitail, Stéphane, Schleinitz, Nicolas, Veit, Véronique, Paul, Pascale, Rubinstein, Menachem, Dinarello, Charles A., Harlé, Jean-Robert, and Kaplanski, Gilles
- Abstract
Hemophagocytic syndrome (HPS) is characterized by an uncontrolled and poorly understood activation of T-helper 1 (Th-1) lymphocytes and macrophages. We studied 20 patients with HPS secondary to infections, autoimmune disease, lymphoma, or cancer and observed that the concentrations of serum interleukin 18 (IL-18), a strong inducer of Th-1 responses, interferon γ (IFN-γ) production, and stimulation of macrophages and natural killer (NK) cells were highly increased in HPS but not in control patients. In contrast, concentrations of its natural inhibitor, the IL-18 binding protein (IL-18BP), were only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS (4.6-fold increase compared with controls; P < .001). Free IL-18 but not IL-12 concentrations significantly correlated with clinical status and the biologic markers of HPS such as anemia (P < .001), hypertriglyceridemia, and hyperferritinemia (P < .01) and also with markers of Th-1 lymphocyte or macrophage activation, such as elevated concentrations of IFN-γ and soluble IL-2 and tumor necrosis factor α (TNF-α) receptor concentrations. Despite high IL-18 elevation, in vitro NK-cell cytotoxicity was severely impaired in HPS patients, in part due to NK-cell lymphopenia that was observed in a majority of patients but also secondary to an intrinsic NK-cell functional deficiency. We concluded that a severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.
- Published
- 2005
- Full Text
- View/download PDF
28. DNAM-1 and PVR Regulate Monocyte Migration through Endothelial Junctions
- Author
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Reymond, Nicolas, Imbert, Anne-Marie, Devilard, Elisabeth, Fabre, Stéphanie, Chabannon, Christian, Xerri, Luc, Farnarier, Catherine, Cantoni, Claudia, Bottino, Cristina, Moretta, Alessandro, Dubreuil, Patrice, and Lopez, Marc
- Abstract
DNAX accessory molecule 1 (DNAM-1; CD226) is a transmembrane glycoprotein involved in T cell and natural killer (NK) cell cytotoxicity. We demonstrated recently that DNAM-1 triggers NK cell–mediated killing of tumor cells upon engagement by its two ligands, poliovirus receptor (PVR; CD155) and Nectin-2 (CD112). In the present paper, we show that PVR and Nectin-2 are expressed at cell junctions on primary vascular endothelial cells. Moreover, the specific binding of a soluble DNAM-1–Fc molecule was detected at endothelial junctions. This binding was almost completely abrogated by anti-PVR monoclonal antibodies (mAbs), but not modified by anti–Nectin-2 mAbs, which demonstrates that PVR is the major DNAM-1 ligand on endothelial cells. Because DNAM-1 is highly expressed on leukocytes, we investigated the role of the DNAM-1–PVR interaction during the monocyte transendothelial migration process. In vitro, both anti–DNAM-1 and anti-PVR mAbs strongly blocked the transmigration of monocytes through the endothelium. Moreover, after anti–DNAM-1 or anti-PVR mAb treatment, monocytes were arrested at the apical surface of the endothelium over intercellular junctions, which strongly suggests that the DNAM-1–PVR interaction occurs during the diapedesis step. Altogether, our results demonstrate that DNAM-1 regulates monocyte extravasation via its interaction with PVR expressed at endothelial junctions on normal cells.
- Published
- 2004
- Full Text
- View/download PDF
29. Correlative study between computerized transverse scanning and stereoimpedoencephalography in space-occupying lesions of the brain
- Author
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J. de Rougemont, Alim-Louis Benabid, Persat Jc, J. P. Chirossel, P. Farnarier, G. Salamon, and M. Barge
- Subjects
Pathology ,medicine.medical_specialty ,Brain Neoplasms ,business.industry ,Conventional surgery ,Electric Conductivity ,Normal tissue ,Glioma ,Brain tissue ,Transverse plane ,Tumour tissue ,Stereotaxy ,medicine ,Humans ,Arterial pCO2 ,Surgery ,Neurology (clinical) ,Tomography, X-Ray Computed ,business ,Electrical impedance ,Biomedical engineering - Abstract
Stereoimpedoencephalography (SIEG) is routinely used by the authors during stereotactic investigations of glial brain tumours prior to stereotactic implantation of isotopes or prior to conventional surgery: the brain tissue impedance is measured along a probe track according to the four electrodes impedance technique. The correlation between the tissue structures and the corresponding impedance values has been studied by comparison with the CATScan data reported on the stereotactic schedules; impedance values are influenced by changes in arterial pCO2 and also by other unknown factors; in order to avoid these uninterpretable changes of the impedance, the recorded values have been normalized with respect to the average impedance along a control track in the normal hemisphere. As a rule, the impedance profile exhibits a "hole" at the site of the pathological processes like tumours as well as surrounding oedema, and the delimitation of the pathological area is very similar to that obtained by the CATScan. There is a good linear correlation between the values of normalized impedance and the x-ray absorption as given by the computer listing of the CATScan. Lastly, statistical values of normalized impedances are determined for the main structures of the brain, showing that the tumour tissue has an impedance equal to half the impedance of the normal tissue.
- Published
- 1979
- Full Text
- View/download PDF
30. Chemotactic agents induce IL-6Rα shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-α-converting enzyme (TACE) type
- Author
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Marin, Valérie, Montero-Julian, Félix, Grès, Sandra, Bongrand, Pierre, Farnarier, Catherine, and Kaplanski, Gilles
- Abstract
Interleukin (IL)-6 transsignaling plays a pivotal role in the shift from neutrophil to monocyte recruitment at the inflammatory site. Release of neutrophil IL-6 receptor-α (IL-6Rα, CD126) in its soluble form is a key step of IL-6 transsignaling, however, its physiological inducers are poorly known. Here, we observed that the neutrophil chemoattractants IL-8, C5a complement fraction, platelet activating factor, leukotriene B4 and N-formyl-methionyl-leucyl-phenylalanine rapidly decreased IL-6Rα membrane expression and increased soluble IL-6Rα concentrations in the neutrophil supernatants, consistent with a shedding process. IL-6Rα shedding involved a TNF-α-converting enzyme-type metalloproteinase since it was partly decreased in the presence of a specific inhibitor, but not cathepsin G since PMSF or α1 antichymotrypsin had no effect. Neutrophil IL-6Rα shedding may be a common feature of neutrophilic infiltrates in various inflammatory situations, allowing IL-6 transsignaling, decreasing neutrophil infiltration and in the meantime favoring monocyte recruitment, thus the initiation of an immune response and subsequently the resolution of inflammation.
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- 2002
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31. The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment
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Marin, Valérie, Farnarier, Catherine, Grès, Sandra, Kaplanski, Solange, Su, Michael S.-S., Dinarello, Charles A., and Kaplanski, Gilles
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Thrombin, the terminal serine protease in the coagulation cascade, is a proinflammatory molecule in vivo and induces endothelial activation in vitro. The cellular signaling mechanisms involved in this function are unknown. The role of the p38 mitogen-activated protein kinase (MAPK) signaling pathway in thrombin-induced chemokine production was studied. Phosphorylation of both p38 MAPK and its substrate, ATF-2, was observed in human umbilical vein endothelial cells (HUVECs) stimulated with thrombin, with a maximum after 5 minutes of stimulation. Using the selective p38 MAPK inhibitor SB203580, there was a significant decrease in thrombin-induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) protein production and messenger RNA steady-state levels. In addition, SB203580 decreased IL-8 and MCP-1 production induced by the thrombin receptor-1 agonist peptide (TRAP), suggesting functional links between the thrombin G protein–coupled receptor and the p38 MAPK pathway. Furthermore, endothelial activation in the presence of SB203580 decreased the chemotactic activity of thrombin-stimulated HUVEC supernatant on neutrophils and monocytic cells. In contrast, the p42/p44 MAPK pathway did not appear to be involved in thrombin- or TRAP-induced endothelial chemokine production, because there was no reduction in the presence of the p42/p44-specific inhibitor PD98059. These results demonstrate that the p38 rather than p42/44 MAPK signaling pathway plays an important role in thrombin-induced endothelial proinflammatory activation and suggest that inhibition of p38 MAPK may be an interesting target for anti-inflammatory strategies in vascular diseases combining thrombosis and inflammation.
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- 2001
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32. Epileptic Nystagmus: electroclinical study of a case
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Gire, Catherine, Somma‐Mauvais, Hélène, Niçaise, Claire, Roussel, Michel, Garnier, Jean‐Marc, and Farnarier, Guy
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Epileptic nystagmus (EN) is a rare form of nystagmus that occurs only during epileptic seizures. We report a case in which EN was first noted in an 8 year‐old boy. Neuro‐imaging was normal. Sharp waves from the left occipital lobe characterised the interictal EEG. Ictal video‐EEG showed the aspects of electric seizures during clinical manifestations e.g.nystagmus. Ambulatory EEG displayed numerous diurnal and nocturnal seizures, but exclusively in REM sleep. After two weeks of sodium valproate treatment, the seizures, EEG focus spikes and nystagmus, as well as the squint, disappeared. During a two‐year follow‐up the child had no further seizures, EEG was normal and the school performance was unaffected. This case has the main features of benign epilepsy, although there are unusual features such as epileptic nystagmus, permanent squint, reduction of EEG paroxysmal abnormalities during NREM, and the presence of seizures during REM sleep. The observation and the significance of EN are discussed with reference to the literature. Content available: Video
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- 2001
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33. Endothelial cell culture: protocol to obtain and cultivate human umbilical endothelial cells
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Marin, V., Kaplanski, G., Gres, S., Farnarier, C., and Bongrand, P.
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- 2001
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34. Comparative CD43 Behavior on Monocytes and Lymphocytes in Kidney Transplants
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Jégo, Sophie, Sabri, Siham, Soler, Mireille, Farnarier, Catherine, Lucioni, Aline, Dussol, Bertrand, Bongrand, Pierre, Berland, Yvon, and Foa, Colette
- Abstract
In human cultured monocytic cells stimulated by cytokines, CD43 was demonstrated to exhibit a modification of sialylated epitopes (dys-sialylation) [Soler et al: Leukoc Biol 1997;61:609–618]. Therefore, we chose to investigate CD43 behavior on patients who present pathological status implicating monocytes after renal graft (KTR). We performed flow cytometry after immune staining using monoclonal antibodies to CD43 sialic acid-dependent (L60) and -independent (L10) epitopes. Compared to normal controls, mean fluorescence intensity was never altered on lymphocytes. Conversely, on monocytes, we found different profiles with L60: 26% of patients having normal CD43 expression, 54% displayed decreased values and 20% had a double population of monocytes, the major one being normal and the minor one with a very low staining. Decreased values were more frequent among KTR during the first 3 months following transplantation. L10 immunostaining was not altered on monocytes in patients with low values of CD43 staining by L60, confirming that the mechanism involved was a CD43 dys-sialylation. We investigated a possible role of cyclosporin (CsA) on human monocytic (THP-1) and lymphoid (Jurkat) cell lines. CsA decreases CD43 expression in monocytic and not in lymphoid cell lines and could be responsible for the specific dys-sialylation of KTR monocytes. Whatever, CD43 dys-sialylation might lead to functional abnormalities of monocytes in KTR, possibly involving the adhesion process.
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- 2000
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35. Hypoxic-ischemic encephalopathy in the term newborn. Contribution of the electroencephalogram and magnetic resonance imaging (MRI) or computed tomography scan (CTS) to the prognostic assessment. A review of 26 cases
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Gire, C., Nicaise, C., Roussel, M., Soula, F., Girard, N., Somma-Mauvais, H., Lagier, P., Dejode, J. M., Farnarier, G., and Garnier, J. M.
- Published
- 2000
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36. Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosusrelated antiphospholipid syndrome: Correlations with the severity of thrombosis
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Kaplanski, Gilles, Cacoub, Patrice, Farnarier, Catherine, Marin, Valérie, Grégoire, Regine, Gatel, Anne, Durand, Jean-Marc, Harlé, Jean-Robert, Bongrand, Pierre, and Piette, Jean-Charles
- Abstract
Recent studies have shown that in vitro endothelial cells are activated by antiphospholipid antibodies and may support leukocyte adhesion. We studied levels of soluble intercellular adhesion molecule 1 (sICAM-1, sCD54), soluble vascular cell adhesion molecule 1 (sVCAM-1, sCD106), and soluble E-selectin (soluble endothelial leukocyte adhesion molecule 1 [sELAM-1, sCD62E]) in sera from patients with primary antiphospholipid syndrome (primary APS), and compared them with those from patients with systemic lupus erythematosusassociated APS (SLE-APS) or pure SLE, as well as with those from 2 control groups composed of healthy volunteers and patients with thrombosis unrelated to autoimmune diseases. Serum samples from 24 patients with primary APS, 15 patients with SLE-APS, 22 patients with pure SLE, 48 control patients with thrombosis, and 18 healthy volunteers were examined using enzyme-linked immunosorbent assays specific for sICAM-1, sVCAM-1, and sELAM-1. Serum levels of sVCAM-1, but not sICAM-1 or sELAM-1, were significantly increased in all patient study groups compared with thrombosis control patients and healthy volunteers, but did not differ between the groups of patients with primary APS, SLE-APS, or pure SLE. Concentrations of sVCAM-1 were significantly higher in primary APS or SLE-APS patients with severe, recurrent thrombosis and were negatively correlated with platelet counts in primary APS patients. In patients with primary APS, sVCAM-1 levels were higher if there was thrombotic kidney involvement and correlated with creatinemia. Serum sVCAM-1 concentrations are increased in patients with primary APS, especially those with repeated thrombotic events or kidney involvement. These findings suggest that endothelial/monocyte interaction may be important in the pathogenesis of primary APS.
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- 2000
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37. Dietary soybean phosphatidylcholines lower lipidemia: mechanisms at the levels of intestine, endothelial cell, and hepato-biliary axis
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Mastellone, I., Polichetti, E., Gres, S., Maisonneuve, C. de la, Domingo, N., Marin, V., Lorec, A. M., Farnarier, C., Portugal, H., and Kaplanski, G.
- Published
- 2000
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38. Thrombin-Activated Human Endothelial Cells Support Monocyte Adhesion In Vitro Following Expression of Intercellular Adhesion Molecule-1 (ICAM-1; CD54) and Vascular Cell Adhesion Molecule-1 (VCAM-1; CD106)
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Kaplanski, Gilles, Marin, Vale´rie, Fabrigoule, Martine, Boulay, Vera, Benoliel, Anne-Marie, Bongrand, Pierre, Kaplanski, Solange, and Farnarier, Catherine
- Abstract
Thrombin, a central molecule in coagulation, is also involved in inflammation. Notably, thrombin induces endothelial neutrophil adhesion, P- and E-selectin expression, and chemokine production. We show here that thrombin induces expression of intercellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106) on human umbilical vein endothelial cells (HUVECs) associated with increased adhesion of monocytes. Thrombin increased mRNA steady-state levels and expression of ICAM-1 over 24 hours. Thrombin-induced VCAM-1 expression exhibited unusual kinetics, reaching maximum levels after 6 to 12 hours, but decreasing to near baseline after 24 hours. Thrombin activity on HUVECs was mediated through interaction with its specific receptor, because ICAM-1 and VCAM-1 expression were similarly induced by the 14-amino acid thrombin receptor-activating peptide. Thrombin-induced ICAM-1 and VCAM-1 expression was significantly inhibited by hirudin, but not by interleukin-1 receptor antagonist or anti-tumor necrosis factor ? monoclonal antibody (MoAb). Thrombin-activated HUVECs significantly increased greater numbers of adhering THP-1 macrophagic cells, peripheral blood mononuclear cells, or purified monocytes than unstimulated HUVECs. This adhesion was inhibited by anti-CD18 and anti-CD49d MoAb, demonstrating that thrombin-induced ICAM-1 and VCAM-1 were functional. These results show that, in addition to selectins, thrombin directly induces a cytokine-independent expression of adhesion molecules of the Ig superfamily on HUVECs that may support firm leukocyte attachment during inflammation. © 1998 by The American Society of Hematology.
- Published
- 1998
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39. Etude des potentiels evoques multimodalitaires dans les epilepsies partielles de l'enfant
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Farnarier, G., Bureau, M., Mancini, J., and Regis, H.
- Abstract
L'étude multimodalitaire des potentiels évoqués a été réalisée sur trois groupes d'enfants ou d'adolescents âgés de 5 à 15 ans. Le premier groupe comprenait 25 sujets normaux non épileptiques; le deuxième groupe comprenait 27 sujets ayant une épilepsie partielle idiopathique (EPI) (épilepsie partielle bénigne de l'enfant à pointes centro-temporales; épilepsie partielle bénigne de l'enfant à paroxysmes occipitaux); le troisième groupe comprenait 20 sujets porteurs d'une épilepsie partielle symptomatique (EPS) avec ou sans lésion anatomique décelable. Pour chaque sujet, ont été enregistrés: les potentiels évoqués visuels par stimulations diffuses (éclairs blancs) et par stimulations structurées (damier réversible), les potentiels évoqués auditifs précoces, les potentiels évoqués somesthésiques par stimulations des nerfs médians droit et gauche au poignet. Sur chacune des courbes obtenues, il a été réalisé une étude de la morphologie des réponses, la mesure des temps de latence des différentes ondes, des latences interpics (temps de conduction) et des amplitudes. Un traitement statistique des données a été pratiqué afin d'apprécier la significativité de la variation des valeurs des différents paramètres entre les différents groupes. Parmi les paramètres significativement modifiés, il a été trouvé: une augmentation des amplitudes dans les EPI et une diminution dans les EPS, en particulier quand il existe une lésion anatomique; une asymétrie interhémisphérique d'amplitude des réponses somesthésiques dans les EPI avec pointes centro-temporales; une augmentation du temps de conduction central somesthésique dans les EPS avec lésion anatomique.
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- 1988
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40. Aspects des potentiels évoqués dans l'infection par le VIH
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Somma-Mauvais, H and Farnarier, G
- Abstract
La revue des données disponibles sur l'étude des potentiels évoqués chez les patients infectés par le VIH montre de nombreuses anomalies aussi bien chez les sujets asymptomatiques sans sida que chez les sujets présentant un sida avec ou sans atteinte neurologique patente. Les potentiels évoqués visuels (PEV) montrent une augmentation de la latence de l'onde P100 chez 22% des sujets asymptomatiques et chez 26% des sujets symptomatiques pour le VIH; les potentiels évoqués auditifs précoces (PEA-p) montrent une augmentation de la latence interpic I-V chez 16% des sujets asymptomatiques et chez 32% des sujets symptomatiques; les potentiels évoqués somesthésiques (PES) par stimulation du nerf médian montrent une augmentation du temps de conduction central chez 6% des sujets asymptomatiques et chez 11% des sujets symptomatiques; les potentiels évoqués somesthésiques (PES) par stimulation du nerf tibial postérieur montrent une augmentation du temps de conduction central chez 4% des sujets asymptomatiques et chez 45% des sujets symptomatiques; les potentiels évoqués moteurs (PEM) par stimulation magnétique montrent une augmentation du temps de conduction central moteur chez 46% des sujets asymptomatiques.
- Published
- 1992
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41. Facial reflex myoclonus induced by language: a neuropsychological and neurophysiological study
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Bartolomei, F., Farnarier, G., Elias, Z., Bronsard, G., Soulayrol, S., Bonnet, A., Chave, B., and Gastaut, J. L.
- Published
- 1999
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42. Indications urgentes de l'EEG dans la situation d'un traumatisme crânien, chez l'enfant et chez l'adulte
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Farnarier, G
- Published
- 1998
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43. Diseappearance of periodic sharp wave complexes in Creutzfeldt-Jakob disease
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Aguglia, U., Gambardella, A., Piane, E. Le, Messina, D., Farnarier, G., Oliveri, R. L., Zappia, M., and Quattrone, A.
- Published
- 1997
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44. Pure Left Hemianacousia: Clinical and Neurophysiological Study
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Donnet, A., Farnarier, G., Schmitt, A., Graziani, N., and Grisoli, F.
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- 1993
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45. Sleep Electroencephalogram at the Early Stage of Creutzfeldt-Jakob Disease
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Donnet, A., Farnarier, G., Gambarelli, D., Aguglia, U., and Regis, H.
- Published
- 1992
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46. Brainstem Auditory Evoked Potentials in Alternating Hemiplegia: Ictal vs Interictal Assessment in One Case
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Santanelli, P., Guerrini, R., Dravet, C., Genton, P., Bureau, M., and Farnarier, G.
- Published
- 1990
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47. The Soluble Receptor of Interleukin 2 is Not a Serum Marker of the Autoimmune Activity in Type I Diabetes Mellitus
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Vialettes, B., Schmitt, N., Hirn, M., Hermitte, L., Kaplanski, S., Farnarier, C., Mattei-Zevacco, C., Simonin, G., and Vague, Ph.
- Abstract
In order to determine if soluble interleukin 2 receptor (IL2R) was useful as a marker in screening for early Type 1 diabetes and in monitoring immunological treatment, we assayed serum IL2R levels in 67 controls, 43 patients with newly diagnosed diabetes and 28 first degree relatives of diabetic patients (5 subjects were islet cell antibody positive). In 23 diabetes, specimens were analysed at 3 and 6 months after diagnosis whether or not cyclosporin A was administered. Seven patients were in a clinical trial using anti IL2R monoclonal antibody and cyclosporin A. Since IL2R level in the normal population is elevated in the first 5 years of life then decreases until adulthood (age:IL2R correlation between 0 and 15 years: r= -0.42, P<0.05), subjects were carefully matched in age. In recent onset diabetes, this negative correlation disappeared and IL2R levels tended to decrease particularly in younger subjects. In Type 1 prediabetic subjects presenting persistent islet-cell antibody serum IL2R was not elevated. During immunological treatment of recent onset diabetes, serum IL2R remained stable and was not modified by cyclosporin A. As expected IL2R became undetectable during treatment with anti IL2R MC Ab. But it rebounded when treatment was stopped with no effect on remission. We concluded that IL2R levels in Type 1 diabetic patients is not useful in screening autoimmune activity or in evaluating the effectiveness of immunosuppressors.
- Published
- 1991
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48. A novel role for E- and P-selectins: shape control of endothelial cell monolayers.
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Kaplanski, G, Farnarier, C, Benoliel, A M, Foa, C, Kaplanski, S, and Bongrand, P
- Abstract
The migration of neutrophils from blood vessels to peripheral tissues is a key step of inflammation. This requires the formation of transient gaps between endothelial cells with concomitant leucocyte squeezing through these narrow apertures and immediate restoration of endothelium continuity. It is currently considered that the main role of selectins is to mediate the initial contact between flowing leucocytes and endothelial cells. We show here that the binding of E- or P-selectins by specific antibodies induces a marked 'rounding up' of interleukin-1- or thrombin-activated human endothelial cells, respectively. Also, anti-E-selectin antibodies trigger a transient increase in cytosolic calcium involving intracellular calcium stores. No such effect is observed when von Willebrand factor or intercellular adhesion molecule 1 are similarly bound. Thus, in addition to promoting the initial interaction between activated endothelium and moving leucocytes, selectins might play a role in the induction of subsequent endothelial deformation, which would facilitate leucocyte arrest and transmigration towards peripheral tissues, and enhance the diffusion of soluble molecules between intravascular and peripheral compartments. Our results are consistent with this hypothesis and demonstrate a new property of endothelial selectins.
- Published
- 1994
49. Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism
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Kaplanski, G, Farnarier, C, Kaplanski, S, Porat, R, Shapiro, L, Bongrand, P, and Dinarello, CA
- Abstract
Inflammation is characterized by migration of neutrophils through the endothelium, and the chemokine interleukin-8 (IL-8) appears to be involved. We asked whether adherence of cells bearing a membrane-form of interleukin 1 (IL-1) induces IL-8 secretion from human umbilical vein endothelial cells (HUVEC) and fibroblasts. Human peripheral blood mononuclear cells (PBMC) were stimulated with endotoxin for 12 hours and then fixed for 4 hours with paraformaldehyde. When these cells were added to HUVEC or fibroblasts, IL-8 production was induced. This stimulation by fixed PBMC was attributed to IL-1, because pretreatment of HUVEC or fibroblasts with IL-1 receptor antagonist (IL-1Ra) reduced the induction by 95% and 80%, respectively, P < .005. Using anti-IL-1 alpha monoclonal antibodies, reduction was complete, whereas anti-IL-1 beta had no effect. IL-1 alpha was shown on the surface of monocytes by fluorescence-activated cell sorter (FACS) analysis. Blockade of IL-1 receptors on PBMC did not affect the activity of membrane-associated IL- 1 alpha, indicating that IL-1 is not anchored to the membrane through its receptors. However, PBMC treated with D-mannose before fixation resulted in a loss of activity; this loss of activity was associated with release of IL-1 alpha, not IL-1 beta, into the supernatant. Thus, anchoring of IL-1 alpha to the membrane may be via a lectin or mannose receptor-like interaction. Blockade of membrane IL-1 alpha required a 30-fold and fivefold excess of IL-1Ra compared with the amount required to block soluble IL-1 beta and IL-1 alpha, respectively. We conclude that the fixed PBMC IL-8 inducing activity is almost entirely caused by IL-1, that this represents IL-1 alpha bound to a surface lectin or mannose receptor on the monocyte, and that it functions in inflammation via juxtacrine interactions.
- Published
- 1994
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50. Granulocyte-endothelium initial adhesion. Analysis of transient binding events mediated by E-selectin in a laminar shear flow
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Kaplanski, G., Farnarier, C., Tissot, O., Pierres, A., Benoliel, A.M., Alessi, M.C., Kaplanski, S., and Bongrand, P.
- Published
- 1993
- Full Text
- View/download PDF
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