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15 results on '"Pérez‐Aranda, María"'

3. Successful treatment of sebaceous adenitis with oclacitinib and low‐dose prednisolone in a dog.

Author

Pérez‐Aranda, María, Yotti, César, Pérez, Judith, and Ginel, Pedro J.

Subjects
*PREDNISOLONE, *LYMPHADENITIS, *TREATMENT effectiveness, *DOGS, *SEBACEOUS gland diseases
Abstract

Finding an effective and well‐tolerated treatment for canine idiopathic sebaceous adenitis (ISA) can be challenging. This case report describes an 8‐year‐old male Rottweiler with ISA successfully treated with a combination of oclacitinib and low doses of prednisolone. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Innovative compounds to battle multirresistance to antibiotics: use of pva-tannic acid nano- particles to inhibit staphylococcus pseudintermedius growth

Author

Pérez Aranda, María, Alcudia Cruz, Ana, Begines Ruiz, Belén, Pajuelo Domínguez, Eloísa, Rodríguez Llorente, Ignacio David, Martínez Muñoz, Guillermo, Martín Valero, María Jesús, Navarro de la Torre, Salvadora, Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica, Universidad de Sevilla. Departamento de Microbiología y Parasitología, Universidad de Sevilla. Departamento de Química Analítica, Universidad de Sevilla. FQM135: Carbohidratos y Polímeros, Universidad de Sevilla. BIO181: Fitomicrobiomas como herramientas biotecnológicas, and Universidad de Sevilla. FQM291: Análisis Químico

Abstract

Antibiotic resistance is an increasing public health problem that affects to numerous pathogens, including Staphylococcus pseudintermedius, which has a high prevalence of methicillin resistance and can be transmitted to humans. The development of new compounds to prevent the appearance of antibiotic resistances and find alternatives to classic therapies is essential to health protection. The main objective of the present study is to determine whether the nanoparticles of polyvinyl alcohol and tannic acid “PVA-TA NPs” are effective to inhibit Staphylococcus pseudintermedius and can be considered as an alternative therapy. The study includes increasing concentration essays of the nanoparticles and establishes, using the determination of turbidity by refractometry that could be a useful tool to inhibit bacterial growth, resulting successful. Nonetheless, further studies to identify the underlying action mechanisms of these nano-particles are going on in our group.

Published
2020

11. Looking for new compounds to battle antibiotic resistance: optimization of organic solvents

Author

Pérez Aranda, María, Alcudia Cruz, Ana, Begines Ruiz, Belén, Pajuelo Domínguez, Eloísa, Rodríguez Llorente, Ignacio David, Martínez Muñoz, Guillermo, Martín Valero, María Jesús, Navarro de la Torre, Salvadora, Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica, Universidad de Sevilla. Departamento de Microbiología y Parasitología, Universidad de Sevilla. Departamento de Química Analítica, Universidad de Sevilla. FQM135: Carbohidratos y Polímeros, Universidad de Sevilla. BIO181: Fitomicrobiomas como herramientas biotecnológicas, and Universidad de Sevilla. FQM291: Análisis Químico

Abstract

A high number of pathogens have shown the capacity of resist to the action of antibiotics. This fact presents a very important problem to public health and highlights the necessity of looking for new substances as alternative to antibiotics. Since some of these substances have a hydrophobic nature they need to be solved in organic solvents. Some of these solvents are also toxic to bacteria, mainly affecting membranes. For these reasons it is necessary to perform a study of the toxicity of organic solvents to bacteria, which has been the aim of this work. Five organic solvents, DMF (dimethylformamide), TBME (tert-butyl methyl ether), THF (tetrahydrofuran), DMSO (dimethyl sulfoxide) and CH2Cl2 (dichloromethane), have been tested, using two of the most prevalent pathogens (Staphylococcus pseudintermedius and Pseudomonas aeruginosa,) both in animals and humans. The results show that, when possible, DMSO followed by TBME are the best options for testing new compounds in Staphylococcus pseudintermedius, whether DMF followed by TBME are the preferred solvents for testing hydrophobic compounds in Pseudomonas aeruginosa.

Published
2020

15. Environmental Impact of Nanoparticles' Application as an Emerging Technology: A Review.

Author

Martínez, Guillermo, Merinero, Manuel, Pérez-Aranda, María, Pérez-Soriano, Eva María, Ortiz, Tamara, Begines, Belén, and Alcudia, Ana

Subjects
NANOPARTICLES, ANIMAL species, NANOMEDICINE, LITERATURE reviews, NANOSTRUCTURED materials, SUSTAINABLE chemistry
Abstract

The unique properties that nanoparticles exhibit, due to their small size, are the principal reason for their numerous applications, but at the same time, this might be a massive menace to the environment. The number of studies that assess the possible ecotoxicity of nanomaterials has been increasing over the last decade to determine if, despite the positive aspects, they should be considered a potential health risk. To evaluate their potential toxicity, models are used in all types of organisms, from unicellular bacteria to complex animal species. In order to better understand the environmental consequences of nanotechnology, this literature review aims to describe and classify nanoparticles, evaluating their life cycle, their environmental releasing capacity and the type of impact, particularly on living beings, highlighting the need to develop more severe and detailed legislation. Due to their diversity, nanoparticles will be discussed in generic terms focusing on the impact of a great variety of them, highlighting the most interesting ones for the industry. [ABSTRACT FROM AUTHOR]

Published
2021
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