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2. Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies

Author

Serrano-Collazo, Crisanta, primary, Pérez-Guzmán, Erick X., additional, Pantoja, Petraleigh, additional, Hassert, Mariah A., additional, Rodríguez, Idia V., additional, Giavedoni, Luis, additional, Hodara, Vida, additional, Parodi, Laura, additional, Cruz, Lorna, additional, Arana, Teresa, additional, Martínez, Melween I., additional, White, Laura, additional, Brien, James D., additional, de Silva, Aravinda, additional, Pinto, Amelia K., additional, and Sariol, Carlos A., additional

Published
2020
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3. Significant control of Zika infection in macaques depends on the elapsing time after dengue exposure

Author

Serrano-Collazo, Crisanta, primary, Pérez-Guzmán, Erick X., additional, Pantoja, Petraleigh, additional, Hassert, Mariah A., additional, Rodríguez, Idia V., additional, Giavedoni, Luis, additional, Hodara, Vida, additional, Parodi, Laura, additional, Cruz, Lorna, additional, Arana, Teresa, additional, Martínez, Melween I., additional, White, Laura, additional, Brien, James D, additional, de Silva, Aravinda, additional, Pinto, Amelia K., additional, and Sariol, Carlos A., additional

Published
2019
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4. Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Author

Pérez-Guzmán, Erick X., primary, Pantoja, Petraleigh, additional, Serrano-Collazo, Crisanta, additional, Hassert, Mariah A., additional, Ortiz-Rosa, Alexandra, additional, Rodríguez, Idia V., additional, Giavedoni, Luis, additional, Hodara, Vida, additional, Parodi, Laura, additional, Cruz, Lorna, additional, Arana, Teresa, additional, White, Laura J., additional, Martínez, Melween I., additional, Weiskopf, Daniela, additional, Brien, James D., additional, de Silva, Aravinda, additional, Pinto, Amelia K., additional, and Sariol, Carlos A., additional

Published
2019
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5. Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

Author

Pantoja, Petraleigh, primary, Pérez-Guzmán, Erick X., additional, Rodríguez, Idia V., additional, White, Laura J., additional, González, Olga, additional, Serrano, Crisanta, additional, Giavedoni, Luis, additional, Hodara, Vida, additional, Cruz, Lorna, additional, Arana, Teresa, additional, Martínez, Melween I., additional, Hassert, Mariah A., additional, Brien, James D., additional, Pinto, Amelia K., additional, de Silva, Aravinda, additional, and Sariol, Carlos A., additional

Published
2017
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6. Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

Author

González, Olga, Rodríguez, Idia V., Pantoja, Petraleigh, Arana, Teresa, Giavedoni, Luis, Sariol, Carlos A., Brien, James D., Pérez-Guzmán, Erick X., White, Laura J., De Silva, Aravinda, Hassert, Mariah A., Cruz, Lorna, Hodara, Vida, Pinto, Amelia K., Martínez, Melween I., and Serrano, Crisanta

Subjects
viruses, virus diseases, biochemical phenomena, metabolism, and nutrition, 3. Good health
Abstract

Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is naïve to flaviviral infection. Our results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease. Rather our results show a reduction in the number of days of ZIKV viremia compared to naïve macaques and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZIKV pathogenesis.

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